FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GRB7-SAMHD1 (FusionGDB2 ID:34677)

Fusion Gene Summary for GRB7-SAMHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7-SAMHD1
Fusion gene ID: 34677
HgeneTgene
Gene symbol

GRB7

SAMHD1

Gene ID

2886

25939

Gene namegrowth factor receptor bound protein 7SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Synonyms-CHBL2|DCIP|HDDC1|MOP-5|SBBI88|hSAMHD1
Cytomap

17q12

20q11.23

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7deoxynucleoside triphosphate triphosphohydrolase SAMHD1SAM domain and HD domain 1SAM domain and HD domain-containing protein 1dNTPasedendritic cell-derived IFNG-induced proteinmonocyte protein 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000578702, ENST00000309156, 
ENST00000309185, ENST00000394204, 
ENST00000394209, ENST00000394211, 
ENST00000445327, 		ENST00000262878, 
ENST00000373694, 
Fusion gene scores* DoF score23 X 20 X 8=36806 X 7 X 5=210
# samples 4211
** MAII scorelog2(42/3680*10)=-3.13124453327825
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/210*10)=-0.932885804141463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB7 [Title/Abstract] AND SAMHD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRB7(37899723)-SAMHD1(35547922), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278

TgeneSAMHD1

GO:0000724

double-strand break repair via homologous recombination

28834754|29670289

TgeneSAMHD1

GO:0006203

dGTP catabolic process

24217394

TgeneSAMHD1

GO:0006974

cellular response to DNA damage stimulus

28834754|29670289

TgeneSAMHD1

GO:0009264

deoxyribonucleotide catabolic process

23601106|26294762

TgeneSAMHD1

GO:0045088

regulation of innate immune response

29670289

TgeneSAMHD1

GO:0046061

dATP catabolic process

24141705

TgeneSAMHD1

GO:0051289

protein homotetramerization

23601106|24217394|26294762

TgeneSAMHD1

GO:0051607

defense response to virus

23601106|26294762

TgeneSAMHD1

GO:0060339

negative regulation of type I interferon-mediated signaling pathway

29670289

TgeneSAMHD1

GO:0110025

DNA strand resection involved in replication fork processing

28834754|29670289


check buttonFusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SAMHD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24U-01AGRB7chr17

37899723

+SAMHD1chr20

35547922

-


Top

Fusion Gene ORF analysis for GRB7-SAMHD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578702ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
3UTR-3CDSENST00000578702ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000309156ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000309156ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000309185ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000309185ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000394204ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000394204ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000394209ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000394209ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000394211ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000394211ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000445327ENST00000262878GRB7chr17

37899723

+SAMHD1chr20

35547922

-
In-frameENST00000445327ENST00000373694GRB7chr17

37899723

+SAMHD1chr20

35547922

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309156GRB7chr1737899723+ENST00000262878SAMHD1chr2035547922-48089202572104615
ENST00000309156GRB7chr1737899723+ENST00000373694SAMHD1chr2035547922-14919202571381374
ENST00000309185GRB7chr1737899723+ENST00000262878SAMHD1chr2035547922-48019132502097615
ENST00000309185GRB7chr1737899723+ENST00000373694SAMHD1chr2035547922-14849132501374374
ENST00000394211GRB7chr1737899723+ENST00000262878SAMHD1chr2035547922-46577691061953615
ENST00000394211GRB7chr1737899723+ENST00000373694SAMHD1chr2035547922-13407691061230374
ENST00000445327GRB7chr1737899723+ENST00000262878SAMHD1chr2035547922-475586762051681
ENST00000445327GRB7chr1737899723+ENST00000373694SAMHD1chr2035547922-143886761328440
ENST00000394209GRB7chr1737899723+ENST00000262878SAMHD1chr2035547922-48169281062112668
ENST00000394209GRB7chr1737899723+ENST00000373694SAMHD1chr2035547922-14999281061389427
ENST00000394204GRB7chr1737899723+ENST00000262878SAMHD1chr2035547922-4601713501897615
ENST00000394204GRB7chr1737899723+ENST00000373694SAMHD1chr2035547922-1284713501174374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309156ENST00000262878GRB7chr1737899723+SAMHD1chr2035547922-0.0005268610.99947315
ENST00000309156ENST00000373694GRB7chr1737899723+SAMHD1chr2035547922-0.0023538630.99764615
ENST00000309185ENST00000262878GRB7chr1737899723+SAMHD1chr2035547922-0.000536750.99946326
ENST00000309185ENST00000373694GRB7chr1737899723+SAMHD1chr2035547922-0.0025619920.99743795
ENST00000394211ENST00000262878GRB7chr1737899723+SAMHD1chr2035547922-0.0005461360.99945384
ENST00000394211ENST00000373694GRB7chr1737899723+SAMHD1chr2035547922-0.0035031140.99649686
ENST00000445327ENST00000262878GRB7chr1737899723+SAMHD1chr2035547922-0.0010338760.9989661
ENST00000445327ENST00000373694GRB7chr1737899723+SAMHD1chr2035547922-0.007043320.99295664
ENST00000394209ENST00000262878GRB7chr1737899723+SAMHD1chr2035547922-0.0005615590.99943846
ENST00000394209ENST00000373694GRB7chr1737899723+SAMHD1chr2035547922-0.0035608320.99643916
ENST00000394204ENST00000262878GRB7chr1737899723+SAMHD1chr2035547922-0.0005621550.99943787
ENST00000394204ENST00000373694GRB7chr1737899723+SAMHD1chr2035547922-0.0037322420.99626774

Top

Fusion Genomic Features for GRB7-SAMHD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GRB7-SAMHD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37899723/chr20:35547922)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB7chr17:37899723chr20:35547922ENST00000309156+615100_186221533.0DomainRas-associating
HgeneGRB7chr17:37899723chr20:35547922ENST00000309185+614100_186221558.6666666666666DomainRas-associating
HgeneGRB7chr17:37899723chr20:35547922ENST00000394204+513100_186221464.0DomainRas-associating
HgeneGRB7chr17:37899723chr20:35547922ENST00000394209+615100_186221533.0DomainRas-associating
HgeneGRB7chr17:37899723chr20:35547922ENST00000394211+615100_186221533.0DomainRas-associating
HgeneGRB7chr17:37899723chr20:35547922ENST00000445327+615100_186244556.0DomainRas-associating
TgeneSAMHD1chr17:37899723chr20:35547922ENST00000262878516352_354232627.0Nucleotide bindingdNTP
TgeneSAMHD1chr17:37899723chr20:35547922ENST00000262878516309_315232627.0RegionSubstrate binding
TgeneSAMHD1chr17:37899723chr20:35547922ENST00000262878516370_375232627.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB7chr17:37899723chr20:35547922ENST00000309156+615229_338221533.0DomainPH
HgeneGRB7chr17:37899723chr20:35547922ENST00000309156+615431_527221533.0DomainSH2
HgeneGRB7chr17:37899723chr20:35547922ENST00000309185+614229_338221558.6666666666666DomainPH
HgeneGRB7chr17:37899723chr20:35547922ENST00000309185+614431_527221558.6666666666666DomainSH2
HgeneGRB7chr17:37899723chr20:35547922ENST00000394204+513229_338221464.0DomainPH
HgeneGRB7chr17:37899723chr20:35547922ENST00000394204+513431_527221464.0DomainSH2
HgeneGRB7chr17:37899723chr20:35547922ENST00000394209+615229_338221533.0DomainPH
HgeneGRB7chr17:37899723chr20:35547922ENST00000394209+615431_527221533.0DomainSH2
HgeneGRB7chr17:37899723chr20:35547922ENST00000394211+615229_338221533.0DomainPH
HgeneGRB7chr17:37899723chr20:35547922ENST00000394211+615431_527221533.0DomainSH2
HgeneGRB7chr17:37899723chr20:35547922ENST00000445327+615229_338244556.0DomainPH
HgeneGRB7chr17:37899723chr20:35547922ENST00000445327+615431_527244556.0DomainSH2
TgeneSAMHD1chr17:37899723chr20:35547922ENST00000262878516164_316232627.0DomainHD
TgeneSAMHD1chr17:37899723chr20:35547922ENST0000026287851645_110232627.0DomainSAM
TgeneSAMHD1chr17:37899723chr20:35547922ENST00000262878516137_145232627.0Nucleotide bindingGTP


Top

Fusion Gene Sequence for GRB7-SAMHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34677_34677_1_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309156_SAMHD1_chr20_35547922_ENST00000262878_length(transcript)=4808nt_BP=920nt
AAGATAATTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTC
CTACCACCTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTC
CTGCTACTCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATC
TGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTC
TGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCC
CCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCC
CCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTC
GCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGG
AGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACT
TCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATAT
CCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAAC
AATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTCATTGTGGC
CATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATT
TTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATG
AGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAAC
ACAAAGTTGGCAACATTATTGATACAATGATTACAGATGCTTTCCTCAAAGCAGATGACTACATAGAGATTACAGGTGCTGGAGGAAAAA
AGTATCGCATTTCTACAGCAATTGACGACATGGAAGCCTATACTAAGCTGACAGATAACATTTTTCTGGAGATTTTATACTCTACTGATC
CCAAATTGAAAGACGCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTATTCAAGTATGTGGGTGAGACGCAGCCAACAGGACAAA
TAAAGATTAAAAGGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCTAAACCCAAAGTATTGCTAGACGTGAAACTGAAGGCTG
AAGATTTTATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATTGATCATGTTAGCTTCTATTGTAAGACTGCCC
CCAACAGAGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAGAAATTTGCAGAGCAGCTGATTCGAGTATATTGTAAGA
AGGTGGACAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGACAGAAATTTCACCAAGCCGCAGGATGGCGATG
TTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCAGTCCAAAATCCAACTCGCCTCCGAGAAGCATCCAAAA
GCAGAGTCCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGTTTACAAACTCCCTCTCCTGCACAATTCATTTAGAGGC
TTCAATCATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATTTTGAATGTACACGCATGCTGAAGCTAAGTAACTTTTA
ATCAAAGAAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATTACCTTGCCTATTTTTAATATTATTAAAGCCTTTCTCC
TTCAGTAGTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTATTTTTTTTCTTTTTTAAGAGACAAGGTTTTGCTCTGT
TGCCCAGCTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGCCCCCCAAGTAGCTGGGACTAAAGTCATGTGCCACCAC
ACCCAGCTTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGTAGAAATGAGACAAGGGTACAAATTGGAACTAGAAATT
GACATTGTCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCGTGAAGAGTTCCCTGTCACCTCAAGTTTGAGGATAGTC
CTCTAAGAGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGCCCCCTACAAGGTGCCAGGTTGGGGTAAAGAGTTGGAG
ATGATGGCCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTTGGGGAAGATCTGAGAGCTCTGGCCTCTTCGTGAGTGG
AACATAAAGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCCCCAAACTAGGCTGTGCCCTGGCTCCGTGGCGGCTCCA
GACCCGGGTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGCCTTCCCACTGCCCAGCCTGGAGAAGGCCTCCCCTGAC
CTGCTCTCTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCCTCAGAGCTCCTCAGACCTGGGACTTTGTTTTTGCTGG
TTCAGTGCATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGG
AGGATTGCTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCT
CCAAAAAAAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACCCAGTGGGCTCCAGGCTCCGCTAGGTAACTTCGTTTTC
CCAGCAGTGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGCACACCTCATTCCCAGTTCTATAGCAATTCACCAAGAA
CAAAGTCTGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATACAGGCCAGTGGGGATGGGAGCCATGAGCCCCGAATGT
CTTCTGCTCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGGGGCAGCCTGAGCAAGTAGGGGAACTCAGACCACAGGC
CAGCAGATTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTCCGTCCACACTGGGGTGAAGAGTACTTGGAATGTCTGC
CATCCTGTATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGTTGGTTACAATTCATAAGAGAATAGTTAAAACACTTCT
CCTCTCATGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCTCAGCAACGCACAAGTGAGGTCAGCCATGGCACTAGGT
CATTCCCATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAGACCTAAGGTCAGGAATGTCATATTTTTCTGTTAAAAT
CATTTTATTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATTCTGTAGTCCTAATATTGTATCATTGTGCTGTCTGCAA
AACAACTTGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTACTTTATGTTCTTTGCAACTGTTTCCATTATGAGAACG
CTGTGCTATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGAT
CACTTGAGGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCCGGGTGAAATTAGC
CGGGCGTGGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGCAGAGGTTGCAGTGA
GCCAAGATCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTCTCAAACAAAAAGAAAGAAAGGAAGGAAGGAAGGAGGG
AAGGAAGGAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAAATATCTTTGCTATTTGTATAAAAATGGAAATTT
TAACAGCTTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAATAGAACTGCAAATTAAAATGACTGGCCACTTCAACTG

>34677_34677_1_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309156_SAMHD1_chr20_35547922_ENST00000262878_length(amino acids)=615AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQ
PTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIR

--------------------------------------------------------------
>34677_34677_2_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309156_SAMHD1_chr20_35547922_ENST00000373694_length(transcript)=1491nt_BP=920nt
AAGATAATTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTC
CTACCACCTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTC
CTGCTACTCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATC
TGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTC
TGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCC
CCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCC
CCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTC
GCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGG
AGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACT
TCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATAT
CCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAAC
AATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTCATTGTGGC
CATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATT
TTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATG
AGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAAC
ACAAAGTTGGCAACATTATTGATACAATGTAAGAAACTTGATTGTCATTTCCCTATAAAATTTTCCTTGATACTTGGCTAGAGTATCATA

>34677_34677_2_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309156_SAMHD1_chr20_35547922_ENST00000373694_length(amino acids)=374AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR

--------------------------------------------------------------
>34677_34677_3_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309185_SAMHD1_chr20_35547922_ENST00000262878_length(transcript)=4801nt_BP=913nt
TTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTCCTACCAC
CTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTCCTGCTAC
TCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCC
ACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGA
GGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTAT
CCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGA
TGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGT
GTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGG
TTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAA
GTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGA
AGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGG
TCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTCATTGTGGCCATATAA
AGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAG
GGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCG
TATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGT
TGGCAACATTATTGATACAATGATTACAGATGCTTTCCTCAAAGCAGATGACTACATAGAGATTACAGGTGCTGGAGGAAAAAAGTATCG
CATTTCTACAGCAATTGACGACATGGAAGCCTATACTAAGCTGACAGATAACATTTTTCTGGAGATTTTATACTCTACTGATCCCAAATT
GAAAGACGCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTATTCAAGTATGTGGGTGAGACGCAGCCAACAGGACAAATAAAGAT
TAAAAGGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCTAAACCCAAAGTATTGCTAGACGTGAAACTGAAGGCTGAAGATTT
TATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATTGATCATGTTAGCTTCTATTGTAAGACTGCCCCCAACAG
AGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAGAAATTTGCAGAGCAGCTGATTCGAGTATATTGTAAGAAGGTGGA
CAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGACAGAAATTTCACCAAGCCGCAGGATGGCGATGTTATAGC
CCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCAGTCCAAAATCCAACTCGCCTCCGAGAAGCATCCAAAAGCAGAGT
CCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGTTTACAAACTCCCTCTCCTGCACAATTCATTTAGAGGCTTCAATC
ATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATTTTGAATGTACACGCATGCTGAAGCTAAGTAACTTTTAATCAAAG
AAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATTACCTTGCCTATTTTTAATATTATTAAAGCCTTTCTCCTTCAGTA
GTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTATTTTTTTTCTTTTTTAAGAGACAAGGTTTTGCTCTGTTGCCCAG
CTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGCCCCCCAAGTAGCTGGGACTAAAGTCATGTGCCACCACACCCAGC
TTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGTAGAAATGAGACAAGGGTACAAATTGGAACTAGAAATTGACATTG
TCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCGTGAAGAGTTCCCTGTCACCTCAAGTTTGAGGATAGTCCTCTAAG
AGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGCCCCCTACAAGGTGCCAGGTTGGGGTAAAGAGTTGGAGATGATGG
CCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTTGGGGAAGATCTGAGAGCTCTGGCCTCTTCGTGAGTGGAACATAA
AGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCCCCAAACTAGGCTGTGCCCTGGCTCCGTGGCGGCTCCAGACCCGG
GTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGCCTTCCCACTGCCCAGCCTGGAGAAGGCCTCCCCTGACCTGCTCT
CTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCCTCAGAGCTCCTCAGACCTGGGACTTTGTTTTTGCTGGTTCAGTG
CATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATTG
CTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCCAAAAA
AAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACCCAGTGGGCTCCAGGCTCCGCTAGGTAACTTCGTTTTCCCAGCAG
TGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGCACACCTCATTCCCAGTTCTATAGCAATTCACCAAGAACAAAGTC
TGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATACAGGCCAGTGGGGATGGGAGCCATGAGCCCCGAATGTCTTCTGC
TCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGGGGCAGCCTGAGCAAGTAGGGGAACTCAGACCACAGGCCAGCAGA
TTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTCCGTCCACACTGGGGTGAAGAGTACTTGGAATGTCTGCCATCCTG
TATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGTTGGTTACAATTCATAAGAGAATAGTTAAAACACTTCTCCTCTCA
TGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCTCAGCAACGCACAAGTGAGGTCAGCCATGGCACTAGGTCATTCCC
ATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAGACCTAAGGTCAGGAATGTCATATTTTTCTGTTAAAATCATTTTA
TTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATTCTGTAGTCCTAATATTGTATCATTGTGCTGTCTGCAAAACAACT
TGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTACTTTATGTTCTTTGCAACTGTTTCCATTATGAGAACGCTGTGCT
ATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGA
GGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCCGGGTGAAATTAGCCGGGCGT
GGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGCAGAGGTTGCAGTGAGCCAAGA
TCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTCTCAAACAAAAAGAAAGAAAGGAAGGAAGGAAGGAGGGAAGGAAG
GAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAAATATCTTTGCTATTTGTATAAAAATGGAAATTTTAACAGC
TTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAATAGAACTGCAAATTAAAATGACTGGCCACTTCAACTGGGTAAGG

>34677_34677_3_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309185_SAMHD1_chr20_35547922_ENST00000262878_length(amino acids)=615AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQ
PTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIR

--------------------------------------------------------------
>34677_34677_4_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309185_SAMHD1_chr20_35547922_ENST00000373694_length(transcript)=1484nt_BP=913nt
TTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTCCTACCAC
CTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTCCTGCTAC
TCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCC
ACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGA
GGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTAT
CCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGA
TGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGT
GTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGG
TTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAA
GTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGA
AGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGG
TCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTCATTGTGGCCATATAA
AGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAG
GGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCG
TATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGT
TGGCAACATTATTGATACAATGTAAGAAACTTGATTGTCATTTCCCTATAAAATTTTCCTTGATACTTGGCTAGAGTATCATACTAGGCT

>34677_34677_4_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000309185_SAMHD1_chr20_35547922_ENST00000373694_length(amino acids)=374AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR

--------------------------------------------------------------
>34677_34677_5_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394204_SAMHD1_chr20_35547922_ENST00000262878_length(transcript)=4601nt_BP=713nt
GACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTC
CGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGC
CTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGC
TCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAG
TAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGC
GAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCG
TGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCT
CCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGCATGAAC
AAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATA
TTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAA
GCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAA
TCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGG
AAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAA
TGATTACAGATGCTTTCCTCAAAGCAGATGACTACATAGAGATTACAGGTGCTGGAGGAAAAAAGTATCGCATTTCTACAGCAATTGACG
ACATGGAAGCCTATACTAAGCTGACAGATAACATTTTTCTGGAGATTTTATACTCTACTGATCCCAAATTGAAAGACGCACGAGAGATTT
TAAAACAAATTGAATACCGTAATCTATTCAAGTATGTGGGTGAGACGCAGCCAACAGGACAAATAAAGATTAAAAGGGAGGACTATGAAT
CTCTTCCAAAAGAGGTTGCCAGTGCTAAACCCAAAGTATTGCTAGACGTGAAACTGAAGGCTGAAGATTTTATAGTGGATGTTATCAACA
TGGATTATGGAATGCAAGAAAAGAATCCAATTGATCATGTTAGCTTCTATTGTAAGACTGCCCCCAACAGAGCAATCAGGATTACTAAAA
ACCAGGTTTCACAACTTCTGCCAGAGAAATTTGCAGAGCAGCTGATTCGAGTATATTGTAAGAAGGTGGACAGAAAGAGTTTGTATGCCG
CAAGACAATATTTTGTTCAGTGGTGTGCAGACAGAAATTTCACCAAGCCGCAGGATGGCGATGTTATAGCCCCACTCATAACACCTCAAA
AAAAGGAATGGAACGACAGTACTTCAGTCCAAAATCCAACTCGCCTCCGAGAAGCATCCAAAAGCAGAGTCCAGCTTTTTAAAGATGACC
CAATGTGAATGTCTGTAGTCAGTTGTTTACAAACTCCCTCTCCTGCACAATTCATTTAGAGGCTTCAATCATAGAATTCTGCAAATTAAT
GACAACTCATGCTTTAATTTTGTATTTTGAATGTACACGCATGCTGAAGCTAAGTAACTTTTAATCAAAGAAATAAGATGGTATTAGGCA
AATCTTACTATACTATGAAAAGCATTACCTTGCCTATTTTTAATATTATTAAAGCCTTTCTCCTTCAGTAGTCTATTTTCTTAGAATAAC
AACTCTTTTATCTATTCTGAACTCTATTTTTTTTCTTTTTTAAGAGACAAGGTTTTGCTCTGTTGCCCAGCTTGGACTCGAACTTTCCTG
GGCTCAAGCGACCCTCCTGCCTCAGCCCCCCAAGTAGCTGGGACTAAAGTCATGTGCCACCACACCCAGCTTACTCTGAACTTTTATGAC
AGATGATTGTTTTTTGTTTTTAATGTAGAAATGAGACAAGGGTACAAATTGGAACTAGAAATTGACATTGTCATTGACAAACATGGCTAA
AAACAAAACATCAAATCCTGCCCCCGTGAAGAGTTCCCTGTCACCTCAAGTTTGAGGATAGTCCTCTAAGAGTGACCTAAGCATAAGTGA
AAGACACCTCCCCTCACCCTTCTAGCCCCCTACAAGGTGCCAGGTTGGGGTAAAGAGTTGGAGATGATGGCCAGGAGTGGCCTCCAACAC
GCTGGTGAGAGGCCTGATTAGGTTTTGGGGAAGATCTGAGAGCTCTGGCCTCTTCGTGAGTGGAACATAAAGCCGCCTCTTGTTGGGAGA
TCCTACCCCAGTGACAGAGGAATCCCCCAAACTAGGCTGTGCCCTGGCTCCGTGGCGGCTCCAGACCCGGGTAGTGCCTTTGTCCCCTGA
ATACTCACTCCCCCGGTCCAGAGGGCCTTCCCACTGCCCAGCCTGGAGAAGGCCTCCCCTGACCTGCTCTCTCAGTATCCTGGAGAGCTG
GCCAGAGGCCATCACAGGCATCATCCTCAGAGCTCCTCAGACCTGGGACTTTGTTTTTGCTGGTTCAGTGCATTTTGTGTATTTAAGAGC
AAACACTAGCCAGGCGTGGCGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATTGCTCGAACCTGGGAGGCGGAG
GTTGCAGTGAGCCTAGATCACGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCCAAAAAAAAAAGCACAAACACTGCAC
TGCCTGTGCTGAAATTAGTGACCACCCAGTGGGCTCCAGGCTCCGCTAGGTAACTTCGTTTTCCCAGCAGTGGAGTGGGCACCACCTTGG
TGGGGCAGTGCCCCTGTGCCCAGGGCACACCTCATTCCCAGTTCTATAGCAATTCACCAAGAACAAAGTCTGCAGTTAGAGCCAAAGCTG
GTGGTGGCCAGAGGGTGCTGAAGATACAGGCCAGTGGGGATGGGAGCCATGAGCCCCGAATGTCTTCTGCTCTGATGCTCCCCGGACTAA
GCCTCCCTGGCACACTGGGAGTGAGGGGCAGCCTGAGCAAGTAGGGGAACTCAGACCACAGGCCAGCAGATTTCCCAGCAGTCCATCACT
GGCCACCGTGTAGCCAGATTCTGTTCCGTCCACACTGGGGTGAAGAGTACTTGGAATGTCTGCCATCCTGTATGATCACCCCACCCCCTG
TCCATCCATCAGTAGATAATAAGGGTTGGTTACAATTCATAAGAGAATAGTTAAAACACTTCTCCTCTCATGCCTACCATGGTGCTGTAT
CAAGGGGATTTGTTCACATATGGGCTCAGCAACGCACAAGTGAGGTCAGCCATGGCACTAGGTCATTCCCATTTTAGCCAAGGTGCCTCT
ATAGGGGTCAGACATCATGTGCCCAGACCTAAGGTCAGGAATGTCATATTTTTCTGTTAAAATCATTTTATTTCTGTGTATCTTACCTTT
AAATCATTGTGGTTTACTCTGAGATTCTGTAGTCCTAATATTGTATCATTGTGCTGTCTGCAAAACAACTTGAATCTATTTTGTTTGCAT
CTTTTGTTACATGTAACGCAGCTGTACTTTATGTTCTTTGCAACTGTTTCCATTATGAGAACGCTGTGCTATTTACAAGGTTACATTTTT
CTTGGCCAGGCGAGGTGGTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGTAAAGAGTTGAGACCAGC
CTGGCTAGCATGGCGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCCGGGTGAAATTAGCCGGGCGTGGTGGTGTGTGCTTGTAATC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCAGGCCACTGCACTCCAGC
CTCGGGGTCAAGAGCGAAACTCTGTCTCAAACAAAAAGAAAGAAAGGAAGGAAGGAAGGAGGGAAGGAAGGAAGGAAAGAGAGAAAGAAA
AGAAAGAAAGAAAGAAAGAAAGAGAAAGAAATATCTTTGCTATTTGTATAAAAATGGAAATTTTAACAGCTTAGCCTCTAGAGAGTTACT
GAACGTGGTTACCTTGGGAATGTAAATAGAACTGCAAATTAAAATGACTGGCCACTTCAACTGGGTAAGGGAAACAGCTGCAATAAAGCT

>34677_34677_5_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394204_SAMHD1_chr20_35547922_ENST00000262878_length(amino acids)=615AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQ
PTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIR

--------------------------------------------------------------
>34677_34677_6_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394204_SAMHD1_chr20_35547922_ENST00000373694_length(transcript)=1284nt_BP=713nt
GACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTC
CGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGC
CTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGC
TCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAG
TAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGC
GAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCG
TGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCT
CCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGCATGAAC
AAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATA
TTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAA
GCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAA
TCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGG
AAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAA
TGTAAGAAACTTGATTGTCATTTCCCTATAAAATTTTCCTTGATACTTGGCTAGAGTATCATACTAGGCTCAACTAGACATTTCTAGATG

>34677_34677_6_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394204_SAMHD1_chr20_35547922_ENST00000373694_length(amino acids)=374AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR

--------------------------------------------------------------
>34677_34677_7_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394209_SAMHD1_chr20_35547922_ENST00000262878_length(transcript)=4816nt_BP=928nt
AGGCAAACCCCAGCCTTGGACTGGCCCTCTCTGATCTCTGAGGCCAGGCTCTAATGTGATTTGAATCTACTTCTAACCCCTTCCAAGCAC
TGCCCTCCCGAATTCTCTGCTCCTCTCCCCACCCCACTGTTGGTCTGTGATTTCGAGGCAGGCGTGGCCCCCTGCAGCCTGGAATGAAGT
CACTGGGGCTGTTTGGAGACCGGGGCTGTTTGGAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGA
GCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGA
TACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCAC
CTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGG
GCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGC
CACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCT
AGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCG
GAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACAC
TGGTATATCCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGT
CATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTC
ATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATG
GGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGT
AGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGC
TTATCAACACAAAGTTGGCAACATTATTGATACAATGATTACAGATGCTTTCCTCAAAGCAGATGACTACATAGAGATTACAGGTGCTGG
AGGAAAAAAGTATCGCATTTCTACAGCAATTGACGACATGGAAGCCTATACTAAGCTGACAGATAACATTTTTCTGGAGATTTTATACTC
TACTGATCCCAAATTGAAAGACGCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTATTCAAGTATGTGGGTGAGACGCAGCCAAC
AGGACAAATAAAGATTAAAAGGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCTAAACCCAAAGTATTGCTAGACGTGAAACT
GAAGGCTGAAGATTTTATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATTGATCATGTTAGCTTCTATTGTAA
GACTGCCCCCAACAGAGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAGAAATTTGCAGAGCAGCTGATTCGAGTATA
TTGTAAGAAGGTGGACAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGACAGAAATTTCACCAAGCCGCAGGA
TGGCGATGTTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCAGTCCAAAATCCAACTCGCCTCCGAGAAGC
ATCCAAAAGCAGAGTCCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGTTTACAAACTCCCTCTCCTGCACAATTCAT
TTAGAGGCTTCAATCATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATTTTGAATGTACACGCATGCTGAAGCTAAGT
AACTTTTAATCAAAGAAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATTACCTTGCCTATTTTTAATATTATTAAAGC
CTTTCTCCTTCAGTAGTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTATTTTTTTTCTTTTTTAAGAGACAAGGTTT
TGCTCTGTTGCCCAGCTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGCCCCCCAAGTAGCTGGGACTAAAGTCATGT
GCCACCACACCCAGCTTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGTAGAAATGAGACAAGGGTACAAATTGGAAC
TAGAAATTGACATTGTCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCGTGAAGAGTTCCCTGTCACCTCAAGTTTGA
GGATAGTCCTCTAAGAGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGCCCCCTACAAGGTGCCAGGTTGGGGTAAAG
AGTTGGAGATGATGGCCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTTGGGGAAGATCTGAGAGCTCTGGCCTCTTC
GTGAGTGGAACATAAAGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCCCCAAACTAGGCTGTGCCCTGGCTCCGTGG
CGGCTCCAGACCCGGGTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGCCTTCCCACTGCCCAGCCTGGAGAAGGCCT
CCCCTGACCTGCTCTCTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCCTCAGAGCTCCTCAGACCTGGGACTTTGTT
TTTGCTGGTTCAGTGCATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTGTGCCTGTAGTCCCAGCTACTTGGGAGGCT
GAGGCAGGAGGATTGCTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCATTGCACTCCAGCCTGGGTGACAGAGTGAGA
CTCCATCTCCAAAAAAAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACCCAGTGGGCTCCAGGCTCCGCTAGGTAACT
TCGTTTTCCCAGCAGTGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGCACACCTCATTCCCAGTTCTATAGCAATTC
ACCAAGAACAAAGTCTGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATACAGGCCAGTGGGGATGGGAGCCATGAGCC
CCGAATGTCTTCTGCTCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGGGGCAGCCTGAGCAAGTAGGGGAACTCAGA
CCACAGGCCAGCAGATTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTCCGTCCACACTGGGGTGAAGAGTACTTGGA
ATGTCTGCCATCCTGTATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGTTGGTTACAATTCATAAGAGAATAGTTAAA
ACACTTCTCCTCTCATGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCTCAGCAACGCACAAGTGAGGTCAGCCATGG
CACTAGGTCATTCCCATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAGACCTAAGGTCAGGAATGTCATATTTTTCT
GTTAAAATCATTTTATTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATTCTGTAGTCCTAATATTGTATCATTGTGCT
GTCTGCAAAACAACTTGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTACTTTATGTTCTTTGCAACTGTTTCCATTA
TGAGAACGCTGTGCTATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGT
GGGCGGATCACTTGAGGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCTCTACTAAAAATACAAAAATTAGCCGGGTG
AAATTAGCCGGGCGTGGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCGGGAGGCAGAGGT
TGCAGTGAGCCAAGATCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTCTCAAACAAAAAGAAAGAAAGGAAGGAAGG
AAGGAGGGAAGGAAGGAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAAATATCTTTGCTATTTGTATAAAAAT
GGAAATTTTAACAGCTTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAATAGAACTGCAAATTAAAATGACTGGCCAC

>34677_34677_7_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394209_SAMHD1_chr20_35547922_ENST00000262878_length(amino acids)=668AA_BP=274
MLLSPPHCWSVISRQAWPPAAWNEVTGAVWRPGLFGGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPE
EVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHV
CEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHE
DLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYR
ISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDF
IVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIA

--------------------------------------------------------------
>34677_34677_8_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394209_SAMHD1_chr20_35547922_ENST00000373694_length(transcript)=1499nt_BP=928nt
AGGCAAACCCCAGCCTTGGACTGGCCCTCTCTGATCTCTGAGGCCAGGCTCTAATGTGATTTGAATCTACTTCTAACCCCTTCCAAGCAC
TGCCCTCCCGAATTCTCTGCTCCTCTCCCCACCCCACTGTTGGTCTGTGATTTCGAGGCAGGCGTGGCCCCCTGCAGCCTGGAATGAAGT
CACTGGGGCTGTTTGGAGACCGGGGCTGTTTGGAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGA
GCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGA
TACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCAC
CTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGG
GCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGC
CACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCT
AGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCG
GAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACAC
TGGTATATCCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGT
CATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTCGAAGATTC
ATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAATGGCATTGATGTGGACAAATG
GGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTCTGTGAAGT
AGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCGCAACTCTTTACACCGTAGAGC
TTATCAACACAAAGTTGGCAACATTATTGATACAATGTAAGAAACTTGATTGTCATTTCCCTATAAAATTTTCCTTGATACTTGGCTAGA

>34677_34677_8_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394209_SAMHD1_chr20_35547922_ENST00000373694_length(amino acids)=427AA_BP=274
MLLSPPHCWSVISRQAWPPAAWNEVTGAVWRPGLFGGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPE
EVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHV
CEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHE
DLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR

--------------------------------------------------------------
>34677_34677_9_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394211_SAMHD1_chr20_35547922_ENST00000262878_length(transcript)=4657nt_BP=769nt
CGTCTCCCTCCCTGAAGACGTGGTCCCAGCCGGGTGTCCTGACGCTCGGGGTTCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCT
CTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCC
TGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCG
AGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGG
GGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTC
TGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCT
GGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGG
AGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTC
CAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAA
TTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACT
TGAATCACCTGTCGAAGATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAA
TGGCATTGATGTGGACAAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAA
GTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCG
CAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAATGATTACAGATGCTTTCCTCAAAGCAGATGACTA
CATAGAGATTACAGGTGCTGGAGGAAAAAAGTATCGCATTTCTACAGCAATTGACGACATGGAAGCCTATACTAAGCTGACAGATAACAT
TTTTCTGGAGATTTTATACTCTACTGATCCCAAATTGAAAGACGCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTATTCAAGTA
TGTGGGTGAGACGCAGCCAACAGGACAAATAAAGATTAAAAGGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCTAAACCCAA
AGTATTGCTAGACGTGAAACTGAAGGCTGAAGATTTTATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATTGA
TCATGTTAGCTTCTATTGTAAGACTGCCCCCAACAGAGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAGAAATTTGC
AGAGCAGCTGATTCGAGTATATTGTAAGAAGGTGGACAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGACAG
AAATTTCACCAAGCCGCAGGATGGCGATGTTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCAGTCCAAAA
TCCAACTCGCCTCCGAGAAGCATCCAAAAGCAGAGTCCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGTTTACAAAC
TCCCTCTCCTGCACAATTCATTTAGAGGCTTCAATCATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATTTTGAATGT
ACACGCATGCTGAAGCTAAGTAACTTTTAATCAAAGAAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATTACCTTGCC
TATTTTTAATATTATTAAAGCCTTTCTCCTTCAGTAGTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTATTTTTTTT
CTTTTTTAAGAGACAAGGTTTTGCTCTGTTGCCCAGCTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGCCCCCCAAG
TAGCTGGGACTAAAGTCATGTGCCACCACACCCAGCTTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGTAGAAATGA
GACAAGGGTACAAATTGGAACTAGAAATTGACATTGTCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCGTGAAGAGT
TCCCTGTCACCTCAAGTTTGAGGATAGTCCTCTAAGAGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGCCCCCTACA
AGGTGCCAGGTTGGGGTAAAGAGTTGGAGATGATGGCCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTTGGGGAAGA
TCTGAGAGCTCTGGCCTCTTCGTGAGTGGAACATAAAGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCCCCAAACTA
GGCTGTGCCCTGGCTCCGTGGCGGCTCCAGACCCGGGTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGCCTTCCCAC
TGCCCAGCCTGGAGAAGGCCTCCCCTGACCTGCTCTCTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCCTCAGAGCT
CCTCAGACCTGGGACTTTGTTTTTGCTGGTTCAGTGCATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTGTGCCTGTA
GTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATTGCTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCATTGCACTCC
AGCCTGGGTGACAGAGTGAGACTCCATCTCCAAAAAAAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACCCAGTGGGC
TCCAGGCTCCGCTAGGTAACTTCGTTTTCCCAGCAGTGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGCACACCTCA
TTCCCAGTTCTATAGCAATTCACCAAGAACAAAGTCTGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATACAGGCCAG
TGGGGATGGGAGCCATGAGCCCCGAATGTCTTCTGCTCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGGGGCAGCCT
GAGCAAGTAGGGGAACTCAGACCACAGGCCAGCAGATTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTCCGTCCACA
CTGGGGTGAAGAGTACTTGGAATGTCTGCCATCCTGTATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGTTGGTTACA
ATTCATAAGAGAATAGTTAAAACACTTCTCCTCTCATGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCTCAGCAACG
CACAAGTGAGGTCAGCCATGGCACTAGGTCATTCCCATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAGACCTAAGG
TCAGGAATGTCATATTTTTCTGTTAAAATCATTTTATTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATTCTGTAGTC
CTAATATTGTATCATTGTGCTGTCTGCAAAACAACTTGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTACTTTATGT
TCTTTGCAACTGTTTCCATTATGAGAACGCTGTGCTATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCTGTAATCCC
AGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCTCTACTAAA
AATACAAAAATTAGCCGGGTGAAATTAGCCGGGCGTGGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGC
TTGAATCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTCTCAAACAA
AAAGAAAGAAAGGAAGGAAGGAAGGAGGGAAGGAAGGAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAAAGAAATAT
CTTTGCTATTTGTATAAAAATGGAAATTTTAACAGCTTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAATAGAACTG

>34677_34677_9_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394211_SAMHD1_chr20_35547922_ENST00000262878_length(amino acids)=615AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR
RAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQ
PTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIR

--------------------------------------------------------------
>34677_34677_10_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394211_SAMHD1_chr20_35547922_ENST00000373694_length(transcript)=1340nt_BP=769nt
CGTCTCCCTCCCTGAAGACGTGGTCCCAGCCGGGTGTCCTGACGCTCGGGGTTCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCT
CTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCC
TGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCG
AGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGG
GGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTC
TGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCT
GGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGG
AGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTC
CAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCACCTTATTAA
TTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACT
TGAATCACCTGTCGAAGATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAATAAAAGAAA
TGGCATTGATGTGGACAAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAA
GTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTCCACACTCG
CAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAATGTAAGAAACTTGATTGTCATTTCCCTATAAAAT

>34677_34677_10_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000394211_SAMHD1_chr20_35547922_ENST00000373694_length(amino acids)=374AA_BP=221
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVE
DSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHR

--------------------------------------------------------------
>34677_34677_11_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000445327_SAMHD1_chr20_35547922_ENST00000262878_length(transcript)=4755nt_BP=867nt
TGCGGGCTGCGGGGAGATGTGGGGAGGGCCCCCTCCACTTTGGAGGGCAGTGAAGGAGAGGGATCCTCTAAATTGTCGAGGCTTCATCTC
TCCAGATTGTATGCCCTTCTCAGCAACACCGCCTCCGGCCCTCCGATGGGAAAGTGGAGGCCGGGACAAGGGCACACAACTGGTTCCGTT
AAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGG
ACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGG
AAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCA
ATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCC
TGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACC
TGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCC
GTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAA
ATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCAC
CTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTA
GGACCACTTGAATCACCTGTCGAAGATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAAT
AAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGC
TTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTC
CACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAATGATTACAGATGCTTTCCTCAAAGCA
GATGACTACATAGAGATTACAGGTGCTGGAGGAAAAAAGTATCGCATTTCTACAGCAATTGACGACATGGAAGCCTATACTAAGCTGACA
GATAACATTTTTCTGGAGATTTTATACTCTACTGATCCCAAATTGAAAGACGCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTA
TTCAAGTATGTGGGTGAGACGCAGCCAACAGGACAAATAAAGATTAAAAGGGAGGACTATGAATCTCTTCCAAAAGAGGTTGCCAGTGCT
AAACCCAAAGTATTGCTAGACGTGAAACTGAAGGCTGAAGATTTTATAGTGGATGTTATCAACATGGATTATGGAATGCAAGAAAAGAAT
CCAATTGATCATGTTAGCTTCTATTGTAAGACTGCCCCCAACAGAGCAATCAGGATTACTAAAAACCAGGTTTCACAACTTCTGCCAGAG
AAATTTGCAGAGCAGCTGATTCGAGTATATTGTAAGAAGGTGGACAGAAAGAGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGT
GCAGACAGAAATTTCACCAAGCCGCAGGATGGCGATGTTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGACAGTACTTCA
GTCCAAAATCCAACTCGCCTCCGAGAAGCATCCAAAAGCAGAGTCCAGCTTTTTAAAGATGACCCAATGTGAATGTCTGTAGTCAGTTGT
TTACAAACTCCCTCTCCTGCACAATTCATTTAGAGGCTTCAATCATAGAATTCTGCAAATTAATGACAACTCATGCTTTAATTTTGTATT
TTGAATGTACACGCATGCTGAAGCTAAGTAACTTTTAATCAAAGAAATAAGATGGTATTAGGCAAATCTTACTATACTATGAAAAGCATT
ACCTTGCCTATTTTTAATATTATTAAAGCCTTTCTCCTTCAGTAGTCTATTTTCTTAGAATAACAACTCTTTTATCTATTCTGAACTCTA
TTTTTTTTCTTTTTTAAGAGACAAGGTTTTGCTCTGTTGCCCAGCTTGGACTCGAACTTTCCTGGGCTCAAGCGACCCTCCTGCCTCAGC
CCCCCAAGTAGCTGGGACTAAAGTCATGTGCCACCACACCCAGCTTACTCTGAACTTTTATGACAGATGATTGTTTTTTGTTTTTAATGT
AGAAATGAGACAAGGGTACAAATTGGAACTAGAAATTGACATTGTCATTGACAAACATGGCTAAAAACAAAACATCAAATCCTGCCCCCG
TGAAGAGTTCCCTGTCACCTCAAGTTTGAGGATAGTCCTCTAAGAGTGACCTAAGCATAAGTGAAAGACACCTCCCCTCACCCTTCTAGC
CCCCTACAAGGTGCCAGGTTGGGGTAAAGAGTTGGAGATGATGGCCAGGAGTGGCCTCCAACACGCTGGTGAGAGGCCTGATTAGGTTTT
GGGGAAGATCTGAGAGCTCTGGCCTCTTCGTGAGTGGAACATAAAGCCGCCTCTTGTTGGGAGATCCTACCCCAGTGACAGAGGAATCCC
CCAAACTAGGCTGTGCCCTGGCTCCGTGGCGGCTCCAGACCCGGGTAGTGCCTTTGTCCCCTGAATACTCACTCCCCCGGTCCAGAGGGC
CTTCCCACTGCCCAGCCTGGAGAAGGCCTCCCCTGACCTGCTCTCTCAGTATCCTGGAGAGCTGGCCAGAGGCCATCACAGGCATCATCC
TCAGAGCTCCTCAGACCTGGGACTTTGTTTTTGCTGGTTCAGTGCATTTTGTGTATTTAAGAGCAAACACTAGCCAGGCGTGGCGGCGTG
TGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATTGCTCGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCACGCCAT
TGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCCAAAAAAAAAAGCACAAACACTGCACTGCCTGTGCTGAAATTAGTGACCACC
CAGTGGGCTCCAGGCTCCGCTAGGTAACTTCGTTTTCCCAGCAGTGGAGTGGGCACCACCTTGGTGGGGCAGTGCCCCTGTGCCCAGGGC
ACACCTCATTCCCAGTTCTATAGCAATTCACCAAGAACAAAGTCTGCAGTTAGAGCCAAAGCTGGTGGTGGCCAGAGGGTGCTGAAGATA
CAGGCCAGTGGGGATGGGAGCCATGAGCCCCGAATGTCTTCTGCTCTGATGCTCCCCGGACTAAGCCTCCCTGGCACACTGGGAGTGAGG
GGCAGCCTGAGCAAGTAGGGGAACTCAGACCACAGGCCAGCAGATTTCCCAGCAGTCCATCACTGGCCACCGTGTAGCCAGATTCTGTTC
CGTCCACACTGGGGTGAAGAGTACTTGGAATGTCTGCCATCCTGTATGATCACCCCACCCCCTGTCCATCCATCAGTAGATAATAAGGGT
TGGTTACAATTCATAAGAGAATAGTTAAAACACTTCTCCTCTCATGCCTACCATGGTGCTGTATCAAGGGGATTTGTTCACATATGGGCT
CAGCAACGCACAAGTGAGGTCAGCCATGGCACTAGGTCATTCCCATTTTAGCCAAGGTGCCTCTATAGGGGTCAGACATCATGTGCCCAG
ACCTAAGGTCAGGAATGTCATATTTTTCTGTTAAAATCATTTTATTTCTGTGTATCTTACCTTTAAATCATTGTGGTTTACTCTGAGATT
CTGTAGTCCTAATATTGTATCATTGTGCTGTCTGCAAAACAACTTGAATCTATTTTGTTTGCATCTTTTGTTACATGTAACGCAGCTGTA
CTTTATGTTCTTTGCAACTGTTTCCATTATGAGAACGCTGTGCTATTTACAAGGTTACATTTTTCTTGGCCAGGCGAGGTGGTCATGCCT
GTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGTAAAGAGTTGAGACCAGCCTGGCTAGCATGGCGAAACCCAGTCT
CTACTAAAAATACAAAAATTAGCCGGGTGAAATTAGCCGGGCGTGGTGGTGTGTGCTTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGG
AGAATCGCTTGAATCCGGGAGGCAGAGGTTGCAGTGAGCCAAGATCAGGCCACTGCACTCCAGCCTCGGGGTCAAGAGCGAAACTCTGTC
TCAAACAAAAAGAAAGAAAGGAAGGAAGGAAGGAGGGAAGGAAGGAAGGAAAGAGAGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAGAA
AGAAATATCTTTGCTATTTGTATAAAAATGGAAATTTTAACAGCTTAGCCTCTAGAGAGTTACTGAACGTGGTTACCTTGGGAATGTAAA

>34677_34677_11_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000445327_SAMHD1_chr20_35547922_ENST00000262878_length(amino acids)=681AA_BP=287
MRGDVGRAPSTLEGSEGEGSSKLSRLHLSRLYALLSNTASGPPMGKWRPGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTP
PGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACR
SVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMV
SSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKR
NGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADD
YIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKP
KVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCAD

--------------------------------------------------------------
>34677_34677_12_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000445327_SAMHD1_chr20_35547922_ENST00000373694_length(transcript)=1438nt_BP=867nt
TGCGGGCTGCGGGGAGATGTGGGGAGGGCCCCCTCCACTTTGGAGGGCAGTGAAGGAGAGGGATCCTCTAAATTGTCGAGGCTTCATCTC
TCCAGATTGTATGCCCTTCTCAGCAACACCGCCTCCGGCCCTCCGATGGGAAAGTGGAGGCCGGGACAAGGGCACACAACTGGTTCCGTT
AAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGG
ACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGG
AAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCA
ATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCC
TGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACC
TGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCC
GTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAA
ATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGCATGAACAAGGCTCAGTTATGATGTTTGAGCAC
CTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATCCCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTA
GGACCACTTGAATCACCTGTCGAAGATTCATTGTGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATAGTATCTAAT
AAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAGGGACTGCCATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGC
TTTATTAAGTTTGCCCGTGTCTGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAGGAAGTTGGAAATCTGTATGACATGTTC
CACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAACATTATTGATACAATGTAAGAAACTTGATTGTCATTTCCC

>34677_34677_12_GRB7-SAMHD1_GRB7_chr17_37899723_ENST00000445327_SAMHD1_chr20_35547922_ENST00000373694_length(amino acids)=440AA_BP=287
MRGDVGRAPSTLEGSEGEGSSKLSRLHLSRLYALLSNTASGPPMGKWRPGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTP
PGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACR
SVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMV
SSCLDAHTGISHEDLIQHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GRB7-SAMHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GRB7-SAMHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GRB7-SAMHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource