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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRHL2-NRBP2 (FusionGDB2 ID:34713)

Fusion Gene Summary for GRHL2-NRBP2

Fusion gene summary

Fusion gene information	Fusion gene name: GRHL2-NRBP2
	Fusion gene ID: 34713
		Hgene	Tgene
	Gene symbol	GRHL2	NRBP2
	Gene ID	79977	340371
	Gene name	grainyhead like transcription factor 2	nuclear receptor binding protein 2
	Synonyms	BOM\|DFNA28\|ECTDS\|PPCD4\|TFCP2L3	TRG16\|pp9320
	Cytomap	8q22.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	grainyhead-like protein 2 homologbrother of mammalian grainyheadgrainyhead-like 2transcription factor CP2-like 3	nuclear receptor-binding protein 2transformation-related protein 16
	Modification date	20200313	20200320
	UniProtAcc	Q6ISB3	Q9NSY0
	Ensembl transtripts involved in fusion gene	ENST00000251808, ENST00000395927, ENST00000517674,	ENST00000327830, ENST00000442628,
Fusion gene scores	* DoF score	25 X 11 X 10=2750	3 X 3 X 3=27
	# samples	25	3
	** MAII score	log2(25/2750*10)=-3.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GRHL2 [Title/Abstract] AND NRBP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRHL2(102661727)-NRBP2(144922401), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRHL2	GO:0008544	epidermis development	23254293
Hgene	GRHL2	GO:0044030	regulation of DNA methylation	23254293
Hgene	GRHL2	GO:0045617	negative regulation of keratinocyte differentiation	23254293
Hgene	GRHL2	GO:0045944	positive regulation of transcription by RNA polymerase II	23814079

Fusion gene breakpoints across GRHL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-D8-A1JL-01A	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-

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Fusion Gene ORF analysis for GRHL2-NRBP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000251808	ENST00000327830	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-
5CDS-5UTR	ENST00000395927	ENST00000327830	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-
In-frame	ENST00000251808	ENST00000442628	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-
In-frame	ENST00000395927	ENST00000442628	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-
intron-3CDS	ENST00000517674	ENST00000442628	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-
intron-5UTR	ENST00000517674	ENST00000327830	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000251808

GRHL2

chr8

102661727

ENST00000442628

NRBP2

chr8

144922401

5354

2036

230

3412

1060

ENST00000395927

GRHL2

chr8

102661727

ENST00000442628

NRBP2

chr8

144922401

5088

1770

3146

1030

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000251808	ENST00000442628	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-	0.003008584	0.9969914
ENST00000395927	ENST00000442628	GRHL2	chr8	102661727	+	NRBP2	chr8	144922401	-	0.002619032	0.9973809

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Fusion Genomic Features for GRHL2-NRBP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRHL2-NRBP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:102661727/chr8:144922401)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRHL2 Q6ISB3	NRBP2 Q9NSY0
FUNCTION: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). {ECO:0000250\|UniProtKB:Q8K5C0, ECO:0000269\|PubMed:19015635, ECO:0000269\|PubMed:20938050, ECO:0000269\|PubMed:20978075, ECO:0000269\|PubMed:23254293, ECO:0000269\|PubMed:25152456, ECO:0000269\|PubMed:29309642, ECO:0000305\|PubMed:12175488}.	FUNCTION: May regulate apoptosis of neural progenitor cells during their differentiation. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRHL2

chr8:102661727

chr8:144922401

ENST00000251808

1_93

566

626.0

Region

Transcription activation

Hgene

GRHL2

chr8:102661727

chr8:144922401

ENST00000395927

1_93

550

610.0

Region

Transcription activation

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NRBP2

chr8:102661727

chr8:144922401

ENST00000442628

38_306

502.0

Domain

Protein kinase

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Fusion Gene Sequence for GRHL2-NRBP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34713_34713_1_GRHL2-NRBP2_GRHL2_chr8_102661727_ENST00000251808_NRBP2_chr8_144922401_ENST00000442628_length(transcript)=5354nt_BP=2036nt
TCCTTGCGAGAAAGTTACCTGTGGCCGCCCAAGTCCGCCACTTTCTGCTCTGTGTCTGCCCATTGCCACGATCCAGGAGGACTCCGCGCC
GCCCGGCCGCCTCCGAGCTCGGGCCCCATGTGAGGGGCCCCCCCTTATCCCACCTTTCCGGCTAGGTGAGGGCGCGAGCGGGCGAGCGAG
CGAGAGTGGTGAGGGGGGACGGAAAAGCAGAATTACCTGTAGCTCTTGTTCTGCCATCTCGGGCGCTCTCACACACCTTCACCTGCACAG
ACTTGAAAGTCCAGTTTCACCAGAGGCTGAGGCTCCAGGAAAAGCGGAGCAAGTTCATTGGATCAAACATGTCACAAGAGTCGGACAATA
ATAAAAGACTAGTGGCCTTAGTGCCCATGCCCAGTGACCCTCCATTCAATACCCGAAGAGCCTACACCAGTGAGGATGAAGCCTGGAAGT
CATACTTGGAGAATCCCCTGACAGCAGCCACCAAGGCCATGATGAGCATTAATGGTGATGAGGACAGTGCTGCTGCCCTCGGCCTGCTCT
ATGACTACTACAAGGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCC
TTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATC
AAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGG
TGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTG
AACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCG
AGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACAT
TTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCA
TAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACA
AAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACA
AGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTT
TCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTT
ATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATG
AAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATAC
CTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTG
CAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCA
TGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACG
ATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGGTAAACCAAGGGAACATGCCAGGGCTTCAGAGCA
CCTTCCTAGCCATGGACACGGAGGAGGGGGTAGAGGTGGTGTGGAACGAGCTCCACTTCGGAGACAGGAAGGCCTTCGCGGCGCACGAGG
AGAAGATCCAGACCGTGTTCGAGCAGCTGGTGCTGGTGGACCACCCGAACATCGTGAAGTTGCACAAGTACTGGCTGGATACCTCTGAGG
CCTGCGCGAGGGTCATCTTCATCACAGAGTACGTGTCATCAGGCAGCCTCAAGCAATTCCTCAAAAAGACCAAGAAGAACCACAAGGCCA
TGAACGCCCGGGCCTGGAAGCGCTGGTGCACGCAGATCCTGTCTGCGCTCAGCTTCCTGCACGCCTGCAGCCCCCCAATCATCCACGGGA
ACCTGACCAGCGACACCATCTTCATTCAGCACAACGGCCTCATCAAGATCGGCTCCGTGTGGCACCGAATCTTCTCCAATGCACTTCCAG
ATGATCTCCGAAGCCCCATCCGCGCTGAGCGAGAGGAACTTCGGAACCTGCACTTCTTCCCCCCAGAGTATGGAGAGGTGGCCGATGGGA
CCGCTGTGGACATCTTCTCCTTTGGGATGTGTGCGCTGGAGATGGCTGTACTGGAAATCCAGACCAATGGGGACACCCGGGTCACAGAGG
AGGCCATTGCTCGCGCCAGGCACTCGCTGAGTGACCCCAACATGCGGGAGTTCATCCTTTGCTGCCTGGCCCGGGACCCTGCCCGCCGGC
CCTCTGCCCACAGCCTCCTCTTCCACCGCGTGCTCTTCGAGGTGCACTCGCTGAAGCTCCTGGCAGCCCACTGCTTCATCCAGCACCAGT
ACCTCATGCCTGAGAATGTGGTGGAGGAGAAGACCAAGGCCATGGACCTGCACGCGGTCTTGGCGGAGCTTCCCCGGCCCCGCAGGCCCC
CGCTGCAGTGGCGGTACTCGGAAGTCTCCTTCATGGAGCTGGACAAATTCCTGGAGGATGTCAGGAATGGAATCTACCCACTGATGAACT
TTGCAGCCACTCGACCCCTGGGGCTGCCCCGTGTGCTGGCCCCACCCCCGGAGGAGGTCCAAAAGGCCAAGACCCCGACGCCAGAGCCCT
TTGACTCTGAGACCAGAAAGGTCATCCAGATGCAGTGCAACCTGGAGAGAAGCGAGGACAAGGCGCGCTGGCATCTCACTCTGCTTCTGG
TGCTGGAAGACCGGCTGCACCGGCAGCTGACCTACGACCTGCTCCCAACGGACAGCGCCCAGGACCTCGCCTCGGAGCTCGTGCACTATG
GCTTCCTCCACGAGGACGACCGGATGAAGCTGGCCGCCTTCCTGGAGAGCACCTTCCTCAAGTACCGTGGGACCCAGGCCTGACCCGGAG
CCCCAGCCCCAGGGGACCATGCCGGGGTGCTGCCTGGGCAGGCCATGTTGGGGAGACTCCAGCACCGTGGGGCTGCCCTCCTCCATGCGC
CTGGGAGCACAAAGGCCCCGGTAGTGAAGGAACCCCCCGTCTCCTGAGAGTGGGGCTGACCCTGCCTTGGGCGCCGAGGGGTTGGGGGGT
GGGTGTGGGGGAGCCGTTAGGCCTCCCAGGTCCTTAGGATCAGGGTTGCCCCCAGAACCCCTTCCCATATCCTCCATTCTCCGCCCTGAG
TTCCTACCCAGGCTGCCTGGCCGGGGCCACTGCCTCCTCAGCATGCAGGAGGCTGCCCTGTAGGGAACCCCAGCTCTGGGGCTTGGGGGT
GAGGGTCAGCCCTGGACAGACCTCTGCCCAGGGAACTGCTCCATGGGGTCTGGGAGAGCAGCCATCCCCTGCTGGCACCATAGACCCACA
CAAGGAGCCTGCACAGCAAGCCAGCGGTGACACACCTGCAGGTGTCAGGCATGGCACTGGGCACAACAGGGACCTGGCAGGAGAAACAGA
CCACAGAGAGGTCTGGAGTTGAGGCTGTTGTCAGCAAAGCCCCTGGTCCCACACAGCTCTGCCCTAGAGCCACCTCTTTGACCCTTTACC
CACCCTGAGACCAGAACTTGCAGCCCCTCTGCAGATCTCCTCTGGCCACTGCAGCCCCTCCAATGGGCTTTTTCTCTCATGCATTCCCTG
GCCTGGAGGCGTCAGGGACCCCACATCCTCCCTGCTCCTCAGACTCACAGCCCCTCCATGTTACCTCCCGCACCTCCTCCCTGGGGCAGC
TGCTCCCTGGGCCTCTGAGGATGTCAGCTCCTGGCTCCCTGCCTCTCTCCCACTCCACTCCTGGCTCAGTCTTAGAGATTTCTATGCCCT
CATGGATTCTACCCCTGCCTTCCTGGCCTCTTGATTCTTGGCTTGCCTCTCCTCCAATTCCAAACTTAGTGAAATGGCCTTAAGCATTTT
AAACTGTATGTATACATTAGCGCATTCATGCCTTTCTAAACGCATTTCAAATGTCAACCAGGAAGGCACACCACTGTATTAGTTTTATAC
TGCCGCTGTAAAATTTACCACAAACTTAGTGACTTAACACAAATTTATTGCAATTCTGTAGGCTGGAAGTCTGACTATGGGTCTCACTGG
ACTAGAATCAAGGCTGGCAGGCTGCCTTCCTTCCTGGAGGTTCTAGGGGAGACTCTGTCTCCTGCTCCTTCAGGCTGCTGGCAGAATCCA
CATCCTTTCGGTGGCAGGGCCAAGGTCCCCACTTTCTTGCTGACTGTAAACTAAGGCCACTTCCAGCTTGTAGAGGCTGCCTACATTCCT
TGGCTCTTGGCCCCCTCCTCCATCTTCAGAGCTAGCAGGTTCAGTCTGTGTCACGAACCATTTCTCTGGTTCCCTGCAGACAGGAAAGGT
TGTCCCTAAGGACTCATGAGATTAGGTTGGGCCCAGCCAGATAATACATGATAATCTCCCTCCTCAAGGTTTTTAATATTAAACACATCT
GCAGGACACATTTTGCCATGTAAACTAACATTCACTGGTTCCAGGGATTAAGGAATGAACCTCTTTTGTTGGGGAAGGGTGGCATTCTGC
TGACCACAGCACTCCAACCAAAAGCCAAAAACCAAAGCAAGACTTACTAACGCATATCAAATAAATTAAAGGTACAAAATCGTGAATCTC
AGTTATCTTAAATATTCCAATACTATTTACAAAATTATTCAAATTCTCACGCCTTCCAACTCAAAATTAGCAATCTAAAGTAATTTCCAT
ATCCTAGATGGAAACCCTCATGCTAAACTGTCTGATTATGCATGGTTCTAAATGGTTTCAGTGGCAAATACATAACATTGTACTACTGAT

>34713_34713_1_GRHL2-NRBP2_GRHL2_chr8_102661727_ENST00000251808_NRBP2_chr8_144922401_ENST00000442628_length(amino acids)=1060AA_BP=602
MPSRALSHTFTCTDLKVQFHQRLRLQEKRSKFIGSNMSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSI
NGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFP
ESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVG
AEEYMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQ
HTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIK
VFCDKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDER
EGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAVNQGNMPGLQSTFLAMDTEEGVEVVWNE
LHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSAL
SFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWHRIFSNALPDDLRSPIRAEREELRNLHFFPPEYGEVADGTAVDIFSFGMCALEMAV
LEIQTNGDTRVTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSLLFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKTKAMDL
HAVLAELPRPRRPPLQWRYSEVSFMELDKFLEDVRNGIYPLMNFAATRPLGLPRVLAPPPEEVQKAKTPTPEPFDSETRKVIQMQCNLER

--------------------------------------------------------------
>34713_34713_2_GRHL2-NRBP2_GRHL2_chr8_102661727_ENST00000395927_NRBP2_chr8_144922401_ENST00000442628_length(transcript)=5088nt_BP=1770nt
ATTGGATCAAACATGTCACAAGAGTCGGACAAGTAAGTGGATCACACGCGCCGGCTGCTGCTACTACTACCACTTTGGGCTGATGGCAAC
TGTAATAAAAGACTAGTGGCCTTAGTGCCCATGCCCAGTGACCCTCCATTCAATACCCGAAGAGCCTACACCAGTGAGGATGAAGCCTGG
AAGTCATACTTGGAGAATCCCCTGACAGCAGCCACCAAGGCCATGATGAGCATTAATGGTGATGAGGACAGTGCTGCTGCCCTCGGCCTG
CTCTATGACTACTACAAGGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAAC
TGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTA
AATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACG
GTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATC
TTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATAC
AGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGC
ACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTAT
GCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAA
GACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGAT
TACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAG
ATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATAC
AGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGA
GATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCC
ATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCAC
TTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGG
CCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACT
GACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGGTAAACCAAGGGAACATGCCAGGGCTTCAG
AGCACCTTCCTAGCCATGGACACGGAGGAGGGGGTAGAGGTGGTGTGGAACGAGCTCCACTTCGGAGACAGGAAGGCCTTCGCGGCGCAC
GAGGAGAAGATCCAGACCGTGTTCGAGCAGCTGGTGCTGGTGGACCACCCGAACATCGTGAAGTTGCACAAGTACTGGCTGGATACCTCT
GAGGCCTGCGCGAGGGTCATCTTCATCACAGAGTACGTGTCATCAGGCAGCCTCAAGCAATTCCTCAAAAAGACCAAGAAGAACCACAAG
GCCATGAACGCCCGGGCCTGGAAGCGCTGGTGCACGCAGATCCTGTCTGCGCTCAGCTTCCTGCACGCCTGCAGCCCCCCAATCATCCAC
GGGAACCTGACCAGCGACACCATCTTCATTCAGCACAACGGCCTCATCAAGATCGGCTCCGTGTGGCACCGAATCTTCTCCAATGCACTT
CCAGATGATCTCCGAAGCCCCATCCGCGCTGAGCGAGAGGAACTTCGGAACCTGCACTTCTTCCCCCCAGAGTATGGAGAGGTGGCCGAT
GGGACCGCTGTGGACATCTTCTCCTTTGGGATGTGTGCGCTGGAGATGGCTGTACTGGAAATCCAGACCAATGGGGACACCCGGGTCACA
GAGGAGGCCATTGCTCGCGCCAGGCACTCGCTGAGTGACCCCAACATGCGGGAGTTCATCCTTTGCTGCCTGGCCCGGGACCCTGCCCGC
CGGCCCTCTGCCCACAGCCTCCTCTTCCACCGCGTGCTCTTCGAGGTGCACTCGCTGAAGCTCCTGGCAGCCCACTGCTTCATCCAGCAC
CAGTACCTCATGCCTGAGAATGTGGTGGAGGAGAAGACCAAGGCCATGGACCTGCACGCGGTCTTGGCGGAGCTTCCCCGGCCCCGCAGG
CCCCCGCTGCAGTGGCGGTACTCGGAAGTCTCCTTCATGGAGCTGGACAAATTCCTGGAGGATGTCAGGAATGGAATCTACCCACTGATG
AACTTTGCAGCCACTCGACCCCTGGGGCTGCCCCGTGTGCTGGCCCCACCCCCGGAGGAGGTCCAAAAGGCCAAGACCCCGACGCCAGAG
CCCTTTGACTCTGAGACCAGAAAGGTCATCCAGATGCAGTGCAACCTGGAGAGAAGCGAGGACAAGGCGCGCTGGCATCTCACTCTGCTT
CTGGTGCTGGAAGACCGGCTGCACCGGCAGCTGACCTACGACCTGCTCCCAACGGACAGCGCCCAGGACCTCGCCTCGGAGCTCGTGCAC
TATGGCTTCCTCCACGAGGACGACCGGATGAAGCTGGCCGCCTTCCTGGAGAGCACCTTCCTCAAGTACCGTGGGACCCAGGCCTGACCC
GGAGCCCCAGCCCCAGGGGACCATGCCGGGGTGCTGCCTGGGCAGGCCATGTTGGGGAGACTCCAGCACCGTGGGGCTGCCCTCCTCCAT
GCGCCTGGGAGCACAAAGGCCCCGGTAGTGAAGGAACCCCCCGTCTCCTGAGAGTGGGGCTGACCCTGCCTTGGGCGCCGAGGGGTTGGG
GGGTGGGTGTGGGGGAGCCGTTAGGCCTCCCAGGTCCTTAGGATCAGGGTTGCCCCCAGAACCCCTTCCCATATCCTCCATTCTCCGCCC
TGAGTTCCTACCCAGGCTGCCTGGCCGGGGCCACTGCCTCCTCAGCATGCAGGAGGCTGCCCTGTAGGGAACCCCAGCTCTGGGGCTTGG
GGGTGAGGGTCAGCCCTGGACAGACCTCTGCCCAGGGAACTGCTCCATGGGGTCTGGGAGAGCAGCCATCCCCTGCTGGCACCATAGACC
CACACAAGGAGCCTGCACAGCAAGCCAGCGGTGACACACCTGCAGGTGTCAGGCATGGCACTGGGCACAACAGGGACCTGGCAGGAGAAA
CAGACCACAGAGAGGTCTGGAGTTGAGGCTGTTGTCAGCAAAGCCCCTGGTCCCACACAGCTCTGCCCTAGAGCCACCTCTTTGACCCTT
TACCCACCCTGAGACCAGAACTTGCAGCCCCTCTGCAGATCTCCTCTGGCCACTGCAGCCCCTCCAATGGGCTTTTTCTCTCATGCATTC
CCTGGCCTGGAGGCGTCAGGGACCCCACATCCTCCCTGCTCCTCAGACTCACAGCCCCTCCATGTTACCTCCCGCACCTCCTCCCTGGGG
CAGCTGCTCCCTGGGCCTCTGAGGATGTCAGCTCCTGGCTCCCTGCCTCTCTCCCACTCCACTCCTGGCTCAGTCTTAGAGATTTCTATG
CCCTCATGGATTCTACCCCTGCCTTCCTGGCCTCTTGATTCTTGGCTTGCCTCTCCTCCAATTCCAAACTTAGTGAAATGGCCTTAAGCA
TTTTAAACTGTATGTATACATTAGCGCATTCATGCCTTTCTAAACGCATTTCAAATGTCAACCAGGAAGGCACACCACTGTATTAGTTTT
ATACTGCCGCTGTAAAATTTACCACAAACTTAGTGACTTAACACAAATTTATTGCAATTCTGTAGGCTGGAAGTCTGACTATGGGTCTCA
CTGGACTAGAATCAAGGCTGGCAGGCTGCCTTCCTTCCTGGAGGTTCTAGGGGAGACTCTGTCTCCTGCTCCTTCAGGCTGCTGGCAGAA
TCCACATCCTTTCGGTGGCAGGGCCAAGGTCCCCACTTTCTTGCTGACTGTAAACTAAGGCCACTTCCAGCTTGTAGAGGCTGCCTACAT
TCCTTGGCTCTTGGCCCCCTCCTCCATCTTCAGAGCTAGCAGGTTCAGTCTGTGTCACGAACCATTTCTCTGGTTCCCTGCAGACAGGAA
AGGTTGTCCCTAAGGACTCATGAGATTAGGTTGGGCCCAGCCAGATAATACATGATAATCTCCCTCCTCAAGGTTTTTAATATTAAACAC
ATCTGCAGGACACATTTTGCCATGTAAACTAACATTCACTGGTTCCAGGGATTAAGGAATGAACCTCTTTTGTTGGGGAAGGGTGGCATT
CTGCTGACCACAGCACTCCAACCAAAAGCCAAAAACCAAAGCAAGACTTACTAACGCATATCAAATAAATTAAAGGTACAAAATCGTGAA
TCTCAGTTATCTTAAATATTCCAATACTATTTACAAAATTATTCAAATTCTCACGCCTTCCAACTCAAAATTAGCAATCTAAAGTAATTT
CCATATCCTAGATGGAAACCCTCATGCTAAACTGTCTGATTATGCATGGTTCTAAATGGTTTCAGTGGCAAATACATAACATTGTACTAC

>34713_34713_2_GRHL2-NRBP2_GRHL2_chr8_102661727_ENST00000395927_NRBP2_chr8_144922401_ENST00000442628_length(amino acids)=1030AA_BP=572
MLLLLPLWADGNCNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSK
ASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHY
PRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQKQGE
GPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNA
VSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQT
QCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEG
TKRVLLYVRKETDDVFDALMLKSPTVKGLMEAVNQGNMPGLQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPN
IVKLHKYWLDTSEACARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKI
GSVWHRIFSNALPDDLRSPIRAEREELRNLHFFPPEYGEVADGTAVDIFSFGMCALEMAVLEIQTNGDTRVTEEAIARARHSLSDPNMRE
FILCCLARDPARRPSAHSLLFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKTKAMDLHAVLAELPRPRRPPLQWRYSEVSFMELDKF
LEDVRNGIYPLMNFAATRPLGLPRVLAPPPEEVQKAKTPTPEPFDSETRKVIQMQCNLERSEDKARWHLTLLLVLEDRLHRQLTYDLLPT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GRHL2-NRBP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRHL2-NRBP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GRHL2-NRBP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source