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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRHPR-ZCCHC7 (FusionGDB2 ID:34730)

Fusion Gene Summary for GRHPR-ZCCHC7

check button Fusion gene summary
Fusion gene informationFusion gene name: GRHPR-ZCCHC7
Fusion gene ID: 34730
HgeneTgene
Gene symbol

GRHPR

ZCCHC7

Gene ID

9380

84186

Gene nameglyoxylate and hydroxypyruvate reductasezinc finger CCHC-type containing 7
SynonymsGLXR|GLYD|PH2AIR1|HSPC086
Cytomap

9p13.2

9p13.2

Type of geneprotein-codingprotein-coding
Descriptionglyoxylate reductase/hydroxypyruvate reductaseepididymis secretory sperm binding proteinglycerate-2-dehydrogenaseglyoxylate reductase and hydroxypyruvate reductasezinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7
Modification date2020032020200320
UniProtAcc

Q9UBQ7

Q8N3Z6

Ensembl transtripts involved in fusion geneENST00000318158, ENST00000607784, 
ENST00000493368, 		ENST00000461038, 
ENST00000534928, ENST00000322831, 
ENST00000336755, 
Fusion gene scores* DoF score6 X 5 X 4=12020 X 16 X 8=2560
# samples 622
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2560*10)=-3.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRHPR [Title/Abstract] AND ZCCHC7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRHPR(37432135)-ZCCHC7(37302185), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRHPR

GO:0046487

glyoxylate metabolic process

10524214

HgeneGRHPR

GO:0055114

oxidation-reduction process

10484776|10524214


check buttonFusion gene breakpoints across GRHPR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZCCHC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AD-A5EK-01AGRHPRchr9

37432135

+ZCCHC7chr9

37302185

+


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Fusion Gene ORF analysis for GRHPR-ZCCHC7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000318158ENST00000461038GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
5CDS-3UTRENST00000607784ENST00000461038GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000318158ENST00000534928GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
5CDS-5UTRENST00000607784ENST00000534928GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000318158ENST00000322831GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
5CDS-intronENST00000607784ENST00000322831GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
In-frameENST00000318158ENST00000336755GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
In-frameENST00000607784ENST00000336755GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
intron-3CDSENST00000493368ENST00000336755GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
intron-3UTRENST00000493368ENST00000461038GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
intron-5UTRENST00000493368ENST00000534928GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+
intron-intronENST00000493368ENST00000322831GRHPRchr9

37432135

+ZCCHC7chr9

37302185

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318158GRHPRchr937432135+ENST00000336755ZCCHC7chr937302185+2853950791971630
ENST00000607784GRHPRchr937432135+ENST00000336755ZCCHC7chr937302185+277387051891628

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318158ENST00000336755GRHPRchr937432135+ZCCHC7chr937302185+0.0024480310.997552
ENST00000607784ENST00000336755GRHPRchr937432135+ZCCHC7chr937302185+0.0025171920.99748284

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Fusion Genomic Features for GRHPR-ZCCHC7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GRHPRchr937432135+ZCCHC7chr937302184+3.67E-060.9999963
GRHPRchr937432135+ZCCHC7chr937302184+3.67E-060.9999963

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GRHPR-ZCCHC7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:37432135/chr9:37302185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRHPR

Q9UBQ7

ZCCHC7

Q8N3Z6

FUNCTION: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRHPRchr9:37432135chr9:37302185ENST00000318158+89162_164288329.0Nucleotide bindingNADP
HgeneGRHPRchr9:37432135chr9:37302185ENST00000318158+89185_188288329.0Nucleotide bindingNADP
HgeneGRHPRchr9:37432135chr9:37302185ENST00000318158+8983_84288329.0RegionSubstrate binding
TgeneZCCHC7chr9:37432135chr9:37302185ENST0000033675519241_258203544.0Zinc fingerCCHC-type 1
TgeneZCCHC7chr9:37432135chr9:37302185ENST0000033675519263_280203544.0Zinc fingerCCHC-type 2
TgeneZCCHC7chr9:37432135chr9:37302185ENST0000033675519304_321203544.0Zinc fingerCCHC-type 3
TgeneZCCHC7chr9:37432135chr9:37302185ENST0000033675519348_365203544.0Zinc fingerCCHC-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRHPRchr9:37432135chr9:37302185ENST00000318158+89293_296288329.0RegionSubstrate binding


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Fusion Gene Sequence for GRHPR-ZCCHC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34730_34730_1_GRHPR-ZCCHC7_GRHPR_chr9_37432135_ENST00000318158_ZCCHC7_chr9_37302185_ENST00000336755_length(transcript)=2853nt_BP=950nt
ACTCCAGCCTGGCCCCGCCCCGGCCCAGCTACATTCCCGGGCCAGCTTCTGTACTGCCAGGTCCGGGTCGGCGGCTGCACTGCGGATGAG
ACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGGGTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGA
GCAGTGGGACTCGGATGAGCCCATCCCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCCGACCA
CGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACCATGTCTGTGGGCATCGACCACTTGGCTTTGGATGA
AATCAAGAAGCGTGGGATCCGAGTTGGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTTACCAC
CTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCGTGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCAC
GCAGAGCACTGTCGGCATCATCGGGCTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTTCTGTA
CACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTGTCTACCCCTGAGCTGGCTGCCCAATCTGATTTCAT
CGTCGTGGCCTGCTCCTTAACACCTGCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTCATCAA
CATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGTGGTAAGATTGCAGCTGCTGGACTGGATGTGACGAG
CCCAGAACCACTGCCTACAAACCACCCTCTCCTGACCCTGAAGAACTGTGGAGAAGATGGTATAAACTGGTCCATCAGTGACAAAGACAT
TGAGGCCCAGATAGCTAATAACCGAACACCTGGAAGATGGACCCAGCGGTACTATTCAGCCAACAAAAACATTATCTGTAGAAATTGTGA
CAAACGTGGTCATTTATCAAAAAACTGCCCCTTACCACGAAAAGTTCGTCGCTGCTTCCTGTGCTCCAGGAGAGGACATCTCCTGTATTC
CTGTCCAGCCCCCCTTTGCGAATACTGTCCTGTGCCTAAGATGTTGGACCACTCATGTCTTTTCAGACATTCCTGGGATAAACAGTGTGA
CCGATGTCATATGCTAGGCCACTATACAGATGCTTGCACAGAAATCTGGAGGCAGTATCACCTAACGACCAAACCTGGACCACCCAAAAA
GCCGAAGACCCCTTCAAGACCATCAGCCTTAGCATATTGCTATCACTGCGCGCAAAAAGGCCATTATGGACACGAATGTCCAGAAAGAGA
AGTGTATGACCCGTCTCCAGTATCTCCATTCATCTGCTACTATGATGACAAATATGAAATTCAGGAGAGAGAAAAGAGACTAAAACAAAA
AATAAAAGTACTCAAGAAAAATGGGGTTATCCCAGAGCCATCCAAGCTACCTTATATAAAAGCAGCAAATGAGAACCCCCACCATGATAT
AAGGAAGGGCCGTGCCTCATGGAAAAGCAACAGGTGGCCTCAAGAAAATAAAGAAACACAAAAAGAAATGAAGAACAAGAATAGAAACTG
GGAGAAGCACAGGAAGGCTGACAGACATCGTGAAGTGGATGAGGATTTTCCCAGGGGCCCCAAAACCTACTCTTCTCCTGGCAGTTTTAA
AACCCAGAAGCCTTCTAAGCCCTTTCACCGTTCATCACATTACCACACGTCAAGAGAAGACAAGTCTCCCAAGGAAGGCAAGAGGGGCAA
GCAGAAGAAAAAGGAGAGGTGCTGGGAAGATGATGACAATGATAACTTATTTCTTATTAAGCAGAGAAAAAAAAAGTCTTAAGCCGTCAG
GCAGCCTCTGATGTGGCTTTTCATTGTTCATTTGGCCTTTGTGTCTATAACCTTCTGGCACTGTGTTTATTATCTATGATTAAATAAAGT
GAGTTTTTGGTTTTGTTTTTTTAATTTCAGCCATTCCTAGAGTTACTGAATATCCATGGAGATCTCAATTCTCTGTGTCCAACAGGATAT
TAGGTAAGAAAGTACAAAGATAAACCTGGACTTCTCCTATTCCAATATGTCATCTTTACTCAGAATCCTAGGGATAGGTAGAAGAATTCA
TCTTTTCAAGAAAGTGTTTTAAAAATACTTTGGGAAAAAAACTGCATCAAAGGTAATTTATCCTCAAATTAAATCCTTGCAGGAAGAGAA
ATTAACACTAAGAAAAAGTCATCAATATTTTTCAACTTTTTTTTTTTTTTTTTTTACTTTGGAAAGGACAATAACTATAAACCTATATCC
AGATTTTCTTTCTGCTGAAGCTGTTGTCAGAATCTTCCTTTGGACAAAACATCACTAGCTGACTATAAAAACAAAAGTGTCATCATTGAA
GCCCTGAAGAGGCAGGGAATTGAGCTTCAGCAAAATACAGGAAAAGAACTATCCAGTATAAATGTCAGAAGACAGATTTCCTAAACAAGT
AAAAGAGACATCAAAAATTTTAACATAATCACAATGAAATCATTTTTTACCACTTTTACAGCGGTGTTTCAAGCGGACTGTCACTCAGAT
CTGCAGAGATGAATATTACTCAAAAAATTTTTTTGTTCTCTTGCATTTTTTTCAACTACCGCAAAGCTATACAGATTTTTTTGTACTTGT

>34730_34730_1_GRHPR-ZCCHC7_GRHPR_chr9_37432135_ENST00000318158_ZCCHC7_chr9_37302185_ENST00000336755_length(amino acids)=630AA_BP=290
MRMRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHL
ALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQ
RFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGL
DVTSPEPLPTNHPLLTLKNCGEDGINWSISDKDIEAQIANNRTPGRWTQRYYSANKNIICRNCDKRGHLSKNCPLPRKVRRCFLCSRRGH
LLYSCPAPLCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYTDACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHEC
PEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNK
NRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKKS

--------------------------------------------------------------
>34730_34730_2_GRHPR-ZCCHC7_GRHPR_chr9_37432135_ENST00000607784_ZCCHC7_chr9_37302185_ENST00000336755_length(transcript)=2773nt_BP=870nt
TGCGGATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGGGTCGCGCTCGCCCGGGCGGCAGACT
GTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATCCCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCC
TCTCCGACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACCATGTCTGTGGGCATCGACCACTTGG
CTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTTGGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGC
TACTTACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCGTGGAAGCCCCTCTGGCTGTGTGGCT
ATGGACTCACGCAGAGCACTGTCGGCATCATCGGGCTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGA
GATTTCTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTGTCTACCCCTGAGCTGGCTGCCCAAT
CTGATTTCATCGTCGTGGCCTGCTCCTTAACACCTGCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTG
TGTTCATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGTGGTAAGATTGCAGCTGCTGGACTGG
ATGTGACGAGCCCAGAACCACTGCCTACAAACCACCCTCTCCTGACCCTGAAGAACTGTGGAGAAGATGGTATAAACTGGTCCATCAGTG
ACAAAGACATTGAGGCCCAGATAGCTAATAACCGAACACCTGGAAGATGGACCCAGCGGTACTATTCAGCCAACAAAAACATTATCTGTA
GAAATTGTGACAAACGTGGTCATTTATCAAAAAACTGCCCCTTACCACGAAAAGTTCGTCGCTGCTTCCTGTGCTCCAGGAGAGGACATC
TCCTGTATTCCTGTCCAGCCCCCCTTTGCGAATACTGTCCTGTGCCTAAGATGTTGGACCACTCATGTCTTTTCAGACATTCCTGGGATA
AACAGTGTGACCGATGTCATATGCTAGGCCACTATACAGATGCTTGCACAGAAATCTGGAGGCAGTATCACCTAACGACCAAACCTGGAC
CACCCAAAAAGCCGAAGACCCCTTCAAGACCATCAGCCTTAGCATATTGCTATCACTGCGCGCAAAAAGGCCATTATGGACACGAATGTC
CAGAAAGAGAAGTGTATGACCCGTCTCCAGTATCTCCATTCATCTGCTACTATGATGACAAATATGAAATTCAGGAGAGAGAAAAGAGAC
TAAAACAAAAAATAAAAGTACTCAAGAAAAATGGGGTTATCCCAGAGCCATCCAAGCTACCTTATATAAAAGCAGCAAATGAGAACCCCC
ACCATGATATAAGGAAGGGCCGTGCCTCATGGAAAAGCAACAGGTGGCCTCAAGAAAATAAAGAAACACAAAAAGAAATGAAGAACAAGA
ATAGAAACTGGGAGAAGCACAGGAAGGCTGACAGACATCGTGAAGTGGATGAGGATTTTCCCAGGGGCCCCAAAACCTACTCTTCTCCTG
GCAGTTTTAAAACCCAGAAGCCTTCTAAGCCCTTTCACCGTTCATCACATTACCACACGTCAAGAGAAGACAAGTCTCCCAAGGAAGGCA
AGAGGGGCAAGCAGAAGAAAAAGGAGAGGTGCTGGGAAGATGATGACAATGATAACTTATTTCTTATTAAGCAGAGAAAAAAAAAGTCTT
AAGCCGTCAGGCAGCCTCTGATGTGGCTTTTCATTGTTCATTTGGCCTTTGTGTCTATAACCTTCTGGCACTGTGTTTATTATCTATGAT
TAAATAAAGTGAGTTTTTGGTTTTGTTTTTTTAATTTCAGCCATTCCTAGAGTTACTGAATATCCATGGAGATCTCAATTCTCTGTGTCC
AACAGGATATTAGGTAAGAAAGTACAAAGATAAACCTGGACTTCTCCTATTCCAATATGTCATCTTTACTCAGAATCCTAGGGATAGGTA
GAAGAATTCATCTTTTCAAGAAAGTGTTTTAAAAATACTTTGGGAAAAAAACTGCATCAAAGGTAATTTATCCTCAAATTAAATCCTTGC
AGGAAGAGAAATTAACACTAAGAAAAAGTCATCAATATTTTTCAACTTTTTTTTTTTTTTTTTTTACTTTGGAAAGGACAATAACTATAA
ACCTATATCCAGATTTTCTTTCTGCTGAAGCTGTTGTCAGAATCTTCCTTTGGACAAAACATCACTAGCTGACTATAAAAACAAAAGTGT
CATCATTGAAGCCCTGAAGAGGCAGGGAATTGAGCTTCAGCAAAATACAGGAAAAGAACTATCCAGTATAAATGTCAGAAGACAGATTTC
CTAAACAAGTAAAAGAGACATCAAAAATTTTAACATAATCACAATGAAATCATTTTTTACCACTTTTACAGCGGTGTTTCAAGCGGACTG
TCACTCAGATCTGCAGAGATGAATATTACTCAAAAAATTTTTTTGTTCTCTTGCATTTTTTTCAACTACCGCAAAGCTATACAGATTTTT

>34730_34730_2_GRHPR-ZCCHC7_GRHPR_chr9_37432135_ENST00000607784_ZCCHC7_chr9_37302185_ENST00000336755_length(amino acids)=628AA_BP=288
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHLAL
DEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDV
TSPEPLPTNHPLLTLKNCGEDGINWSISDKDIEAQIANNRTPGRWTQRYYSANKNIICRNCDKRGHLSKNCPLPRKVRRCFLCSRRGHLL
YSCPAPLCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYTDACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPE
REVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRHPR-ZCCHC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRHPR-ZCCHC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRHPR-ZCCHC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource