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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRIA1-RAD17 (FusionGDB2 ID:34733)

Fusion Gene Summary for GRIA1-RAD17

check button Fusion gene summary
Fusion gene informationFusion gene name: GRIA1-RAD17
Fusion gene ID: 34733
HgeneTgene
Gene symbol

GRIA1

RAD17

Gene ID

2890

5884

Gene nameglutamate ionotropic receptor AMPA type subunit 1RAD17 checkpoint clamp loader component
SynonymsGLUH1|GLUR1|GLURA|GluA1|HBGR1CCYC|HRAD17|R24L|RAD17SP|RAD24
Cytomap

5q33.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor 1AMPA 1AMPA-selective glutamate receptor 1gluR-1gluR-AgluR-K1glutamate receptor, ionotropic, AMPA 1cell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17)
Modification date2020032920200313
UniProtAcc

P42261

.
Ensembl transtripts involved in fusion geneENST00000285900, ENST00000340592, 
ENST00000448073, ENST00000518142, 
ENST00000518783, ENST00000521843, 
ENST00000518862, 		ENST00000358030, 
ENST00000380774, ENST00000521422, 
ENST00000282891, ENST00000305138, 
ENST00000345306, ENST00000354312, 
ENST00000504177, ENST00000354868, 
ENST00000361732, ENST00000509734, 
Fusion gene scores* DoF score4 X 4 X 2=327 X 9 X 4=252
# samples 49
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRIA1 [Title/Abstract] AND RAD17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRIA1(153085627)-RAD17(68677728), # samples:3
Anticipated loss of major functional domain due to fusion event.GRIA1-RAD17 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GRIA1-RAD17 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GRIA1-RAD17 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GRIA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAD17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2M7-06AGRIA1chr5

153085627

-RAD17chr5

68677728

+
ChimerDB4SKCMTCGA-EE-A2M7-06AGRIA1chr5

153085627

+RAD17chr5

68677728

+


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Fusion Gene ORF analysis for GRIA1-RAD17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000285900ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000285900ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000285900ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000340592ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000340592ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000340592ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000448073ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000448073ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000448073ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000518142ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000518142ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000518142ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000518783ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000518783ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000518783ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000521843ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000521843ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-5UTRENST00000521843ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000285900ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000285900ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000285900ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000285900ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000285900ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000340592ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000340592ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000340592ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000340592ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000340592ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000448073ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000448073ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000448073ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000448073ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000448073ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518142ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518142ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518142ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518142ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518142ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518783ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518783ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518783ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518783ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000518783ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000521843ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000521843ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000521843ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000521843ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
5CDS-intronENST00000521843ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000285900ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000285900ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000285900ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000340592ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000340592ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000340592ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000448073ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000448073ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000448073ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000518142ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000518142ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000518142ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000518783ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000518783ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000518783ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000521843ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000521843ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
Frame-shiftENST00000521843ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-3CDSENST00000518862ENST00000354868GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-3CDSENST00000518862ENST00000361732GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-3CDSENST00000518862ENST00000509734GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-5UTRENST00000518862ENST00000358030GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-5UTRENST00000518862ENST00000380774GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-5UTRENST00000518862ENST00000521422GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-intronENST00000518862ENST00000282891GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-intronENST00000518862ENST00000305138GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-intronENST00000518862ENST00000345306GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-intronENST00000518862ENST00000354312GRIA1chr5

153085627

+RAD17chr5

68677728

+
intron-intronENST00000518862ENST00000504177GRIA1chr5

153085627

+RAD17chr5

68677728

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GRIA1-RAD17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GRIA1chr5153085627+RAD17chr568677727+1.13E-060.9999989
GRIA1chr5153085627+RAD17chr568677727+1.13E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GRIA1-RAD17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:153085627/:68677728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRIA1

P42261

.
FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GRIA1-RAD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRIA1-RAD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRIA1-RAD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRIA1-RAD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource