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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRID1-AFAP1L2 (FusionGDB2 ID:34741)

Fusion Gene Summary for GRID1-AFAP1L2

Fusion gene summary

Fusion gene information	Fusion gene name: GRID1-AFAP1L2
	Fusion gene ID: 34741
		Hgene	Tgene
	Gene symbol	GRID1	AFAP1L2
	Gene ID	2894	84632
	Gene name	glutamate ionotropic receptor delta type subunit 1	actin filament associated protein 1 like 2
	Synonyms	GluD1	CTB-1144G6.4\|KIAA1914\|XB130
	Cytomap	10q23.1-q23.2	10q25.3
	Type of gene	protein-coding	protein-coding
	Description	glutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunit	actin filament-associated protein 1-like 2AFAP1-like protein 2CTB-1144G6.6
	Modification date	20200313	20200313
	UniProtAcc	Q9ULK0	Q8N4X5
	Ensembl transtripts involved in fusion gene	ENST00000327946, ENST00000536331, ENST00000552278,	ENST00000491814, ENST00000304129, ENST00000369271, ENST00000545353,
Fusion gene scores	* DoF score	10 X 8 X 6=480	5 X 4 X 4=80
	# samples	11	5
	** MAII score	log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRID1 [Title/Abstract] AND AFAP1L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRID1(88123698)-AFAP1L2(116100490), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AFAP1L2	GO:0006954	inflammatory response	17412687
Tgene	AFAP1L2	GO:0007346	regulation of mitotic cell cycle	17412687
Tgene	AFAP1L2	GO:0032675	regulation of interleukin-6 production	17412687
Tgene	AFAP1L2	GO:0032757	positive regulation of interleukin-8 production	17412687
Tgene	AFAP1L2	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	17412687
Tgene	AFAP1L2	GO:0045893	positive regulation of transcription, DNA-templated	17412687

Fusion gene breakpoints across GRID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AFAP1L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A6YR-01A	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-

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Fusion Gene ORF analysis for GRID1-AFAP1L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000327946	ENST00000491814	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
In-frame	ENST00000327946	ENST00000304129	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
In-frame	ENST00000327946	ENST00000369271	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
In-frame	ENST00000327946	ENST00000545353	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-3CDS	ENST00000536331	ENST00000304129	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-3CDS	ENST00000536331	ENST00000369271	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-3CDS	ENST00000536331	ENST00000545353	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-3CDS	ENST00000552278	ENST00000304129	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-3CDS	ENST00000552278	ENST00000369271	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-3CDS	ENST00000552278	ENST00000545353	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-intron	ENST00000536331	ENST00000491814	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-
intron-intron	ENST00000552278	ENST00000491814	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000327946	GRID1	chr10	88123698	-	ENST00000304129	AFAP1L2	chr10	116100490	-	3980	321	86	2761	891
ENST00000327946	GRID1	chr10	88123698	-	ENST00000369271	AFAP1L2	chr10	116100490	-	3968	321	86	2749	887
ENST00000327946	GRID1	chr10	88123698	-	ENST00000545353	AFAP1L2	chr10	116100490	-	3191	321	86	2920	944

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000327946	ENST00000304129	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-	0.001486317	0.99851364
ENST00000327946	ENST00000369271	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-	0.001516158	0.99848384
ENST00000327946	ENST00000545353	GRID1	chr10	88123698	-	AFAP1L2	chr10	116100490	-	0.004197712	0.99580234

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Fusion Genomic Features for GRID1-AFAP1L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRID1-AFAP1L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:88123698/chr10:116100490)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRID1 Q9ULK0	AFAP1L2 Q8N4X5
FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.	FUNCTION: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269\|PubMed:17412687}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AFAP1L2

chr10:88123698

chr10:116100490

ENST00000304129

652_749

819.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AFAP1L2

chr10:88123698

chr10:116100490

ENST00000369271

652_749

815.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AFAP1L2

chr10:88123698

chr10:116100490

ENST00000304129

175_271

819.0

Domain

PH 1

Tgene

AFAP1L2

chr10:88123698

chr10:116100490

ENST00000304129

353_447

819.0

Domain

PH 2

Tgene

AFAP1L2

chr10:88123698

chr10:116100490

ENST00000369271

175_271

815.0

Domain

PH 1

Tgene

AFAP1L2

chr10:88123698

chr10:116100490

ENST00000369271

353_447

815.0

Domain

PH 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

21_562

1010.0

Topological domain

Extracellular

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

584_637

1010.0

Topological domain

Cytoplasmic

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

659_830

1010.0

Topological domain

Extracellular

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

852_1009

1010.0

Topological domain

Cytoplasmic

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

563_583

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

638_658

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123698

chr10:116100490

ENST00000327946

831_851

1010.0

Transmembrane

Helical

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Fusion Gene Sequence for GRID1-AFAP1L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34741_34741_1_GRID1-AFAP1L2_GRID1_chr10_88123698_ENST00000327946_AFAP1L2_chr10_116100490_ENST00000304129_length(transcript)=3980nt_BP=321nt
ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG
AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG
AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT
ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTCCTCA
AGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGCAGCA
GCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAGCAGG
GCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGATTCCAGAAC
GGAAACAGCTTGCCATCCCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAG
AGGCTGTGAGCAGCTCCTACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCG
GCATCGAGCTGATGCGTGACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCA
AGGACAACAGGCTTCTGTGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGG
AGAAGCAAGTGCGGAAGAAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGG
CTGAGCAGTGGCTCAGGGTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGC
GCTTTAACTGCCAGAAACCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAG
AAACCAAAGACGTCAAGAAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGC
CTGTGGAGAGGTCCCTCGAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATC
ACCTGCACTTCTACCAGGACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCC
CCGACCACCTCTACTCCTTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGC
TGGGTCTCCTGCTCTCTGAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTG
TGAGTGCGGCCAAAAACTCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCC
AGGAGGAGCTGTATGACGACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAA
ATGAGAGAGAATCTGACCGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCT
CCCCGACGTTGTCCTGCCTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGT
GTCCAGAGAACCTGGGAGAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAAC
AGCAGAGAATCTCCTTCCCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCG
TGACCAGTGCAGAGATCAAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGA
AGGAAGAAATCCGGGGGCACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCC
TGGCGAGCCTGGAGCAGAAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGG
AGGTGAAGGACAACCTGAAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATGTGAGCCCCC
GCCCCAAAGCTGTCACACCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGG
TCACAGGCAAAGGCACTGTACTCCAGAAAGCCAAGGAATGGGAGAAGAAAGGAGCAAGTTAGAAAACAAGCTTCATCTAAAGACTCTCAT
GTCAATGTGGACCTTGGTGACAATCCTGCTTTGTTAAAGCAAAAACTATGCGAAAGGGTGAGTCTGTTTAGAAGAAAAAGCAAAGACTGA
GGTACTGTGAATGGAGAGCTTCAGCTAAGAGGAGGCTCTGTCCCTTTTCAGAGCCAAAGGAAATAATACAACAAAAAGGAGGCTTCTTTG
GAGACCTAAGTCTATTGGATGTAAACAAGACGTTGTATTTAGGGATGTTCTGTGTTTCTTTCTTTTTTGAAGTTGTCATCAATTGCTTTA
CTAAGATTTTTAAATAGTGAAAACCTCCTGTTTAGACTTTGGTGGAAGATGAATCAAGGAAGCAGGGCCCTGTCTTATGGGTCACGTGTC
TTTGGTGAGTGAGAAGACCTAAACTCCTGGCCATCATCTCTTATCCAATACTTAGCAGTTGGGGATTAAACCATCCTTGCCTTCAGTTCT
CTCCAATATTACCAGGCCCAACTCAGTCTTCAGTGATTTTAAACAGCATTGACATCATCTGTAAAACCATCATCTGTAAAACCATCTATG
ACATGAGTTTTGAGAAACAATAATGGGGAAAATATTTGGGACCAAGCTGAAGCACTAATCCCACTAAGTTAAAGACTTCTTTCCAGTCCA
AGGCAGGCCTGAATCAACTGTCTTTAAATAAAATTTTAAGTGATGCTGTATTATATATAGGAAAAAATGCTTAAAATCCTGTCATTTAGA
ACAGTGAAAAGTATCTTTTGAGATTAAAGTGACTCTTTACTGTAGGAAAAATATTACTCTGTGTTTACAGATTCATTGCTGTGGTCAGGC
CATTTTTAAGGGAAGAGTTATTTAATATAAATAGTCTCTGATTTTAAGTTCTGTTTAATGTTCATTCTCCTTCCAAGAACAAAGTGGTGA
TTTTTGGTTAGGGTGATCGCCCTCTTAAAATTGGCAGTGCTGTTCCTTGTGCTGCCCCTGTCTTTTCCTCTGATGGCATTTTTTTTTTTT
TTTTTTTAACACAGGTTGAAACATTTCATCTATTATCTCTGCCTCATTTCTGGAGGGTTGTGTATCAGTTCTCTAACACTTGTTCCTGAG
AACTAAATGTCTTTTTTATTCTTATTTCCTCTCTCATAAACATTTGGTGACCTTTTACCAAGTGGTGAGTTAGTTAGGTTTTTTAAAATA

>34741_34741_1_GRID1-AFAP1L2_GRID1_chr10_88123698_ENST00000327946_AFAP1L2_chr10_116100490_ENST00000304129_length(amino acids)=891AA_BP=78
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEALEQLLTELDDF
LKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIP
ERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCV
IKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDA
QRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRD
NHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSC
IVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQA
SSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRL
RVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSI

--------------------------------------------------------------
>34741_34741_2_GRID1-AFAP1L2_GRID1_chr10_88123698_ENST00000327946_AFAP1L2_chr10_116100490_ENST00000369271_length(transcript)=3968nt_BP=321nt
ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG
AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG
AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT
ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTCCTCA
AGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGCAGCA
GCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAGCAGG
GCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGATTCCAGAAC
GGAAACAGCTTGCCATCCCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAG
AGGCTGTGAGCAGCTCCTACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCG
GCATCGAGCTGATGCGTGACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCA
AGGACAACAGGCTTCTGTGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGG
AGAAGCAAGTGCGGAAGAAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGG
CTGAGCAGTGGCTCAGGGTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGC
GCTTTAACTGCCAGAAACCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAG
AAACCAAAGACGTCAAGAAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGC
CTGTGGAGAGGTCCCTCGAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATC
ACCTGCACTTCTACCAGGACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCC
CCGACCACCTCTACTCCTTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGC
TGGGTCTCCTGCTCTCTGAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTG
TGAGTGCGGCCAAAAACTCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCC
AGGAGGAGCTGTATGACGACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAA
ATGAGAGAGAATCTGACCGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCT
CCCCGACGTTGTCCTGCCTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGT
GTCCAGAGAACCTGGGAGAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAAC
AGCAGAGAATCTCCTTCCCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCG
TGACCAGTGCAGAGATCAAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGA
AGGAAGAAATCCGGGGGCACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCC
TGGCGAGCCTGGAGCAGAAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGG
AGGTGAAGGACAACCTGAAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATCCCAAAGCTG
TCACACCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGGTCACAGGCAAAG
GCACTGTACTCCAGAAAGCCAAGGAATGGGAGAAGAAAGGAGCAAGTTAGAAAACAAGCTTCATCTAAAGACTCTCATGTCAATGTGGAC
CTTGGTGACAATCCTGCTTTGTTAAAGCAAAAACTATGCGAAAGGGTGAGTCTGTTTAGAAGAAAAAGCAAAGACTGAGGTACTGTGAAT
GGAGAGCTTCAGCTAAGAGGAGGCTCTGTCCCTTTTCAGAGCCAAAGGAAATAATACAACAAAAAGGAGGCTTCTTTGGAGACCTAAGTC
TATTGGATGTAAACAAGACGTTGTATTTAGGGATGTTCTGTGTTTCTTTCTTTTTTGAAGTTGTCATCAATTGCTTTACTAAGATTTTTA
AATAGTGAAAACCTCCTGTTTAGACTTTGGTGGAAGATGAATCAAGGAAGCAGGGCCCTGTCTTATGGGTCACGTGTCTTTGGTGAGTGA
GAAGACCTAAACTCCTGGCCATCATCTCTTATCCAATACTTAGCAGTTGGGGATTAAACCATCCTTGCCTTCAGTTCTCTCCAATATTAC
CAGGCCCAACTCAGTCTTCAGTGATTTTAAACAGCATTGACATCATCTGTAAAACCATCATCTGTAAAACCATCTATGACATGAGTTTTG
AGAAACAATAATGGGGAAAATATTTGGGACCAAGCTGAAGCACTAATCCCACTAAGTTAAAGACTTCTTTCCAGTCCAAGGCAGGCCTGA
ATCAACTGTCTTTAAATAAAATTTTAAGTGATGCTGTATTATATATAGGAAAAAATGCTTAAAATCCTGTCATTTAGAACAGTGAAAAGT
ATCTTTTGAGATTAAAGTGACTCTTTACTGTAGGAAAAATATTACTCTGTGTTTACAGATTCATTGCTGTGGTCAGGCCATTTTTAAGGG
AAGAGTTATTTAATATAAATAGTCTCTGATTTTAAGTTCTGTTTAATGTTCATTCTCCTTCCAAGAACAAAGTGGTGATTTTTGGTTAGG
GTGATCGCCCTCTTAAAATTGGCAGTGCTGTTCCTTGTGCTGCCCCTGTCTTTTCCTCTGATGGCATTTTTTTTTTTTTTTTTTTAACAC
AGGTTGAAACATTTCATCTATTATCTCTGCCTCATTTCTGGAGGGTTGTGTATCAGTTCTCTAACACTTGTTCCTGAGAACTAAATGTCT
TTTTTATTCTTATTTCCTCTCTCATAAACATTTGGTGACCTTTTACCAAGTGGTGAGTTAGTTAGGTTTTTTAAAATAAAATGTTCATTG

>34741_34741_2_GRID1-AFAP1L2_GRID1_chr10_88123698_ENST00000327946_AFAP1L2_chr10_116100490_ENST00000369271_length(amino acids)=887AA_BP=78
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEALEQLLTELDDF
LKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIP
ERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCV
IKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDA
QRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRD
NHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSC
IVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQA
SSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRL
RVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSI

--------------------------------------------------------------
>34741_34741_3_GRID1-AFAP1L2_GRID1_chr10_88123698_ENST00000327946_AFAP1L2_chr10_116100490_ENST00000545353_length(transcript)=3191nt_BP=321nt
ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG
AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG
AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT
ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTCCTCA
AGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGCAGCA
GCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAGCAGG
GCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGAGAATCCTGA
CCTTGGGCCAGATCTCGGGTGCCCAGAGCTTTTCTCCAGATGGGACCCACCTGACGGGAACGGAGTTTCTTGGAGGCTGGAGCTGGAGGC
CCAGCCAGATCAGGCTGATGAGCCCTGGGACCCACTGGGGAGACCTTACTGCCACAGAGATTCCAGAACGGAAACAGCTTGCCATCCCAA
AGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAGAGGCTGTGAGCAGCTCCTACG
AGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCGGCATCGAGCTGATGCGTGACG
CCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCAAGGACAACAGGCTTCTGTGCT
ACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGGAGAAGCAAGTGCGGAAGAAGG
AGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGGCTGAGCAGTGGCTCAGGGTCA
TCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGCGCTTTAACTGCCAGAAACCAG
ATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAGAAACCAAAGACGTCAAGAAGA
AATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGCCTGTGGAGAGGTCCCTCGAGA
CATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATCACCTGCACTTCTACCAGGACC
GGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCCCCGACCACCTCTACTCCTTCC
GCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGCTGGGTCTCCTGCTCTCTGAGT
CAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTGTGAGTGCGGCCAAAAACTCTC
TCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCCAGGAGGAGCTGTATGACGACG
TGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAAATGAGAGAGAATCTGACCGAG
TGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCTCCCCGACGTTGTCCTGCCTGG
ACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGTGTCCAGAGAACCTGGGAGAAC
AGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAACAGCAGAGAATCTCCTTCCCAC
CGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCGTGACCAGTGCAGAGATCAAGC
TTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGAAGGAAGAAATCCGGGGGCACC
TGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCCTGGCGAGCCTGGAGCAGAAGC
TGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGGAGGTGAAGGACAACCTGAAGA
AGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATGTGAGCCCCCGCCCCAAAGCTGTCACACCTG
CCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGGTCACAGGCAAAGGCACTGTAC
TCCAGAAAGCCAAGGAATGGGAGAAGAAAGGAGCAAGTTAGAAAACAAGCTTCATCTAAAGACTCTCATGTCAATGTGGACCTTGGTGAC
AATCCTGCTTTGTTAAAGCAAAAACTATGCGAAAGGGTGAGTCTGTTTAGAAGAAAAAGCAAAGACTGAGGTACTGTGAATGGAGAGCTT
CAGCTAAGAGGAGGCTCTGTCCCTTTTCAGAGCCAAAGGAAATAATACAACAAAAAGGAGGCTTCTTTGGAGACCTAAGTCTATTGGATG

>34741_34741_3_GRID1-AFAP1L2_GRID1_chr10_88123698_ENST00000327946_AFAP1L2_chr10_116100490_ENST00000545353_length(amino acids)=944AA_BP=78
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEALEQLLTELDDF
LKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMRI
LTLGQISGAQSFSPDGTHLTGTEFLGGWSWRPSQIRLMSPGTHWGDLTATEIPERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSS
YESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRK
KEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVK
KKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYS
FRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYD
DVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLG
EQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRG
HLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GRID1-AFAP1L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	GRID1	chr10:88123698	chr10:116100490	ENST00000327946	-	2	16	21_436	78.33333333333333	1010.0	CBLN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRID1-AFAP1L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRID1-AFAP1L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source