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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRID1-GLUD1 (FusionGDB2 ID:34744)

Fusion Gene Summary for GRID1-GLUD1

Fusion gene summary

Fusion gene information	Fusion gene name: GRID1-GLUD1
	Fusion gene ID: 34744
		Hgene	Tgene
	Gene symbol	GRID1	GLUD1
	Gene ID	2894	2746
	Gene name	glutamate ionotropic receptor delta type subunit 1	glutamate dehydrogenase 1
	Synonyms	GluD1	GDH\|GDH1\|GLUD
	Cytomap	10q23.1-q23.2	10q23.2
	Type of gene	protein-coding	protein-coding
	Description	glutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunit	glutamate dehydrogenase 1, mitochondrialepididymis secretory sperm binding proteinepididymis tissue sperm binding protein Li 18mPglutamate dehydrogenase (NAD(P)+)
	Modification date	20200313	20200329
	UniProtAcc	Q9ULK0	P00367
	Ensembl transtripts involved in fusion gene	ENST00000327946, ENST00000536331, ENST00000552278,	ENST00000537649, ENST00000544149, ENST00000465164, ENST00000277865,
Fusion gene scores	* DoF score	10 X 8 X 6=480	10 X 7 X 8=560
	# samples	11	11
	** MAII score	log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRID1 [Title/Abstract] AND GLUD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRID1(88123698)-GLUD1(88836413), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GLUD1	GO:0006537	glutamate biosynthetic process	11032875
Tgene	GLUD1	GO:0006538	glutamate catabolic process	6121377\|11032875

Fusion gene breakpoints across GRID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GLUD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-K4-A6MB-01A	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
ChimerDB4	BLCA	TCGA-K4-A6MB	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-

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Fusion Gene ORF analysis for GRID1-GLUD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000327946	ENST00000537649	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
5CDS-5UTR	ENST00000327946	ENST00000537649	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
5CDS-5UTR	ENST00000327946	ENST00000544149	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
5CDS-5UTR	ENST00000327946	ENST00000544149	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
5CDS-intron	ENST00000327946	ENST00000465164	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
5CDS-intron	ENST00000327946	ENST00000465164	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
In-frame	ENST00000327946	ENST00000277865	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
In-frame	ENST00000327946	ENST00000277865	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-3CDS	ENST00000536331	ENST00000277865	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-3CDS	ENST00000536331	ENST00000277865	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-3CDS	ENST00000552278	ENST00000277865	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-3CDS	ENST00000552278	ENST00000277865	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000536331	ENST00000537649	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000536331	ENST00000537649	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000536331	ENST00000544149	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000536331	ENST00000544149	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000552278	ENST00000537649	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000552278	ENST00000537649	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000552278	ENST00000544149	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-5UTR	ENST00000552278	ENST00000544149	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-intron	ENST00000536331	ENST00000465164	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-intron	ENST00000536331	ENST00000465164	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-
intron-intron	ENST00000552278	ENST00000465164	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-
intron-intron	ENST00000552278	ENST00000465164	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000327946	GRID1	chr10	88123698	-	ENST00000277865	GLUD1	chr10	88836413	-	2818	321	86	1552	488
ENST00000327946	GRID1	chr10	88123697	-	ENST00000277865	GLUD1	chr10	88836413	-	2818	321	86	1552	488

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000327946	ENST00000277865	GRID1	chr10	88123698	-	GLUD1	chr10	88836413	-	0.000339572	0.9996604
ENST00000327946	ENST00000277865	GRID1	chr10	88123697	-	GLUD1	chr10	88836413	-	0.000339572	0.9996604

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Fusion Genomic Features for GRID1-GLUD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRID1-GLUD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:88123698/chr10:88836413)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRID1 Q9ULK0	GLUD1 P00367
FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.	FUNCTION: Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250\|UniProtKB:P10860, ECO:0000269\|PubMed:11032875, ECO:0000269\|PubMed:11254391, ECO:0000269\|PubMed:11297618, ECO:0000269\|PubMed:16023112, ECO:0000269\|PubMed:16959573, ECO:0000269\|PubMed:9571255}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

21_562

1010.0

Topological domain

Extracellular

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

584_637

1010.0

Topological domain

Cytoplasmic

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

659_830

1010.0

Topological domain

Extracellular

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

852_1009

1010.0

Topological domain

Cytoplasmic

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

21_562

1010.0

Topological domain

Extracellular

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

584_637

1010.0

Topological domain

Cytoplasmic

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

659_830

1010.0

Topological domain

Extracellular

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

852_1009

1010.0

Topological domain

Cytoplasmic

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

563_583

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

638_658

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123697

chr10:88836413

ENST00000327946

831_851

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

563_583

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

638_658

1010.0

Transmembrane

Helical

Hgene

GRID1

chr10:88123698

chr10:88836413

ENST00000327946

831_851

1010.0

Transmembrane

Helical

Tgene

GLUD1

chr10:88123697

chr10:88836413

ENST00000277865

141_143

148

559.0

Nucleotide binding

NAD

Tgene

GLUD1

chr10:88123698

chr10:88836413

ENST00000277865

141_143

148

559.0

Nucleotide binding

NAD

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Fusion Gene Sequence for GRID1-GLUD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34744_34744_1_GRID1-GLUD1_GRID1_chr10_88123697_ENST00000327946_GLUD1_chr10_88836413_ENST00000277865_length(transcript)=2818nt_BP=321nt
ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG
AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG
AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT
ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAAGTAA
AAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGGGGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGA
ACTATACTGATAATGAATTGGAAAAGATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGATGTGC
CTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCAC
ACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAA
ATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATG
TGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATG
GTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCT
TGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTG
CTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATG
CTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATT
CTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAG
AGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTA
TGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATG
AAGCTGGTGTGACCTTCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTA
CATGTAACCACAGAAATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGA
AAGAAATTAAGGTTAGCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAA
ATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGA
GCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAG
AAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTT
TCTGTTTATGAATATTATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGA
CTCAAACAGTGAATGCCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCAT
GTATTGTCCAGCAGACATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTC
AGAATTTGCTTACTATAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGG
TTGACTAATTAAACAATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGC
CAATGGCCCCTACTCACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACAT
CCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAA
GAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTGATAAAAGC

>34744_34744_1_GRID1-GLUD1_GRID1_chr10_88123697_ENST00000327946_GLUD1_chr10_88836413_ENST00000277865_length(amino acids)=488AA_BP=78
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEGIRYSTDVSVDE
VKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDIN
AHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNP
DGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYL
NAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQ

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>34744_34744_2_GRID1-GLUD1_GRID1_chr10_88123698_ENST00000327946_GLUD1_chr10_88836413_ENST00000277865_length(transcript)=2818nt_BP=321nt
ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG
AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG
AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT
ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAAGTAA
AAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGGGGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGA
ACTATACTGATAATGAATTGGAAAAGATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGATGTGC
CTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCAC
ACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAA
ATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATG
TGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATG
GTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCT
TGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTG
CTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATG
CTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATT
CTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAG
AGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTA
TGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATG
AAGCTGGTGTGACCTTCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTA
CATGTAACCACAGAAATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGA
AAGAAATTAAGGTTAGCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAA
ATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGA
GCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAG
AAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTT
TCTGTTTATGAATATTATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGA
CTCAAACAGTGAATGCCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCAT
GTATTGTCCAGCAGACATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTC
AGAATTTGCTTACTATAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGG
TTGACTAATTAAACAATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGC
CAATGGCCCCTACTCACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACAT
CCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAA
GAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTGATAAAAGC

>34744_34744_2_GRID1-GLUD1_GRID1_chr10_88123698_ENST00000327946_GLUD1_chr10_88836413_ENST00000277865_length(amino acids)=488AA_BP=78
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEGIRYSTDVSVDE
VKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDIN
AHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNP
DGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYL
NAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQ

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Fusion Gene PPI Analysis for GRID1-GLUD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	GRID1	chr10:88123697	chr10:88836413	ENST00000327946	-	2	16	21_436	78.33333333333333	1010.0	CBLN1
Hgene	GRID1	chr10:88123698	chr10:88836413	ENST00000327946	-	2	16	21_436	78.33333333333333	1010.0	CBLN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GRID1-GLUD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRID1-GLUD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source