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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRIK4-TMPRSS4 (FusionGDB2 ID:34797)

Fusion Gene Summary for GRIK4-TMPRSS4

check button Fusion gene summary
Fusion gene informationFusion gene name: GRIK4-TMPRSS4
Fusion gene ID: 34797
HgeneTgene
Gene symbol

GRIK4

TMPRSS4

Gene ID

2900

56649

Gene nameglutamate ionotropic receptor kainate type subunit 4transmembrane serine protease 4
SynonymsEAA1|GRIK|GluK4|KA1CAPH2|MT-SP2|TMPRSS3
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, kainate 4excitatory amino acid receptor 1glutamate receptor KA1glutamate receptor, ionotropic, kainate 4transmembrane protease serine 4channel-activating protease 2membrane-type serine protease 2transmembrane protease, serine 4transmembrane serine protease 3type II membrane serine protease
Modification date2020032020200313
UniProtAcc

Q16099

.
Ensembl transtripts involved in fusion geneENST00000438375, ENST00000527524, 
ENST00000527130, 		ENST00000437212, 
ENST00000522307, ENST00000522824, 
ENST00000523251, ENST00000518413, 
ENST00000534111, 
Fusion gene scores* DoF score6 X 6 X 5=1803 X 3 X 2=18
# samples 63
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GRIK4 [Title/Abstract] AND TMPRSS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRIK4(120776202)-TMPRSS4(117965537), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMPRSS4

GO:0010468

regulation of gene expression

29529050

TgeneTMPRSS4

GO:0045967

negative regulation of growth rate

29529050


check buttonFusion gene breakpoints across GRIK4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMPRSS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1P1-01AGRIK4chr11

120776202

-TMPRSS4chr11

117965537

+


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Fusion Gene ORF analysis for GRIK4-TMPRSS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000438375ENST00000437212GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000438375ENST00000522307GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000438375ENST00000522824GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000438375ENST00000523251GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000527524ENST00000437212GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000527524ENST00000522307GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000527524ENST00000522824GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-5UTRENST00000527524ENST00000523251GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-intronENST00000438375ENST00000518413GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
5CDS-intronENST00000527524ENST00000518413GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
In-frameENST00000438375ENST00000534111GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
In-frameENST00000527524ENST00000534111GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
intron-3CDSENST00000527130ENST00000534111GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
intron-5UTRENST00000527130ENST00000437212GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
intron-5UTRENST00000527130ENST00000522307GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
intron-5UTRENST00000527130ENST00000522824GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
intron-5UTRENST00000527130ENST00000523251GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+
intron-intronENST00000527130ENST00000518413GRIK4chr11

120776202

-TMPRSS4chr11

117965537

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000527524GRIK4chr11120776202-ENST00000534111TMPRSS4chr11117965537+704517632873067926
ENST00000438375GRIK4chr11120776202-ENST00000534111TMPRSS4chr11117965537+710018183423122926

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000527524ENST00000534111GRIK4chr11120776202-TMPRSS4chr11117965537+0.0002843540.9997156
ENST00000438375ENST00000534111GRIK4chr11120776202-TMPRSS4chr11117965537+0.0002409790.999759

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Fusion Genomic Features for GRIK4-TMPRSS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRIK4-TMPRSS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:120776202/chr11:117965537)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRIK4

Q16099

.
FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMPRSS4chr11:120776202chr11:117965537ENST00000437212013205_4340438.0DomainPeptidase S1
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000043721201361_930438.0DomainNote=LDL-receptor class A
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000043721201394_2040438.0DomainSRCR
TgeneTMPRSS4chr11:120776202chr11:117965537ENST00000522824013205_4340433.0DomainPeptidase S1
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000052282401361_930433.0DomainNote=LDL-receptor class A
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000052282401394_2040433.0DomainSRCR
TgeneTMPRSS4chr11:120776202chr11:117965537ENST00000534111013205_4341436.0DomainPeptidase S1
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000053411101361_931436.0DomainNote=LDL-receptor class A
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000053411101394_2041436.0DomainSRCR
TgeneTMPRSS4chr11:120776202chr11:117965537ENST000004372120131_320438.0Topological domainCytoplasmic
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000043721201354_4370438.0Topological domainExtracellular
TgeneTMPRSS4chr11:120776202chr11:117965537ENST000005228240131_320433.0Topological domainCytoplasmic
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000052282401354_4370433.0Topological domainExtracellular
TgeneTMPRSS4chr11:120776202chr11:117965537ENST000005341110131_321436.0Topological domainCytoplasmic
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000053411101354_4371436.0Topological domainExtracellular
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000043721201333_530438.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000052282401333_530433.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS4chr11:120776202chr11:117965537ENST0000053411101333_531436.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220862_865492957.0Compositional biasNote=Poly-Arg
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321862_865492957.0Compositional biasNote=Poly-Arg
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-122021_545492957.0Topological domainExtracellular
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220567_623492957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220645_804492957.0Topological domainExtracellular
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220826_956492957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-132121_545492957.0Topological domainExtracellular
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321567_623492957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321645_804492957.0Topological domainExtracellular
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321826_956492957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220546_566492957.0TransmembraneHelical
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220624_644492957.0TransmembraneHelical
HgeneGRIK4chr11:120776202chr11:117965537ENST00000438375-1220805_825492957.0TransmembraneHelical
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321546_566492957.0TransmembraneHelical
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321624_644492957.0TransmembraneHelical
HgeneGRIK4chr11:120776202chr11:117965537ENST00000527524-1321805_825492957.0TransmembraneHelical


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Fusion Gene Sequence for GRIK4-TMPRSS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34797_34797_1_GRIK4-TMPRSS4_GRIK4_chr11_120776202_ENST00000438375_TMPRSS4_chr11_117965537_ENST00000534111_length(transcript)=7100nt_BP=1818nt
CCTTTCCCGATTCCCCGACGTTTCGGGAGGAGTGGGGTCGGAGCGCAGGGCTGGGAAGGGTCTTAGGACCCAGGAAGGAGACGGGTGCCT
CCCAGAGAGGACCCCATCCCCTCCGAGGTCCGGGCGGCTCCCGGCCTCTCCCTGGGGTGCCGTAGCCCCCCTCGACCCGCCTTCCCGCAG
CCGCAGTCGTTCGGGCCTGGAGGTGGCCGGGCATCGGTGCCGACGCCGCGAGGGCAGCGCCCGCGGCGGGAATACTAATGCACCCTAAAG
GGCACGGCCGCCGCCGCAGCAGAGTTATGTCATGCCCAGGCCAGCAGGGGGCTCCATGAGGATTCATAGAAGATGCCCCGCGTCTCGGCG
CCTTTGGTGCTGCTTCCTGCGTGGCTCGTGATGGTCGCCTGCAGCCCGCACTCCTTGAGGATCGCTGCTATCTTGGACGACCCCATGGAG
TGCAGCAGAGGGGAGCGGCTCTCCATCACCCTGGCCAAGAACCGCATCAACCGCGCTCCTGAGAGGCTGGGCAAGGCCAAGGTCGAAGTG
GACATCTTTGAGCTTCTCAGAGACAGCGAGTACGAGACTGCAGAAACCATGTGTCAGATCCTCCCCAAGGGGGTGGTCGCTGTCCTCGGA
CCATCGTCCAGCCCAGCCTCCAGCTCCATCATCAGCAACATCTGTGGAGAGAAGGAGGTCCCTCACTTCAAAGTGGCCCCAGAGGAGTTC
GTCAAGTTCCAGTTCCAGAGATTCACAACCCTGAACCTCCACCCCAGCAACACTGACATCAGCGTGGCTGTAGCTGGGATCCTGAACTTC
TTCAACTGCACCACCGCCTGCCTCATCTGTGCCAAAGCAGAATGCCTTTTAAACCTAGAGAAGCTGCTCCGGCAATTCCTTATCTCCAAG
GACACGCTGTCCGTCCGCATGCTGGATGACACCCGGGACCCCACCCCGCTCCTCAAGGAGATCCGGGACGACAAGACCGCCACCATCATC
ATCCACGCCAACGCCTCCATGTCCCACACCATCCTCCTGAAGGCAGCCGAACTTGGGATGGTGTCAGCCTATTACACATACATCTTCACT
AATCTGGAGTTCTCACTCCAGAGAATGGACAGCCTTGTGGATGATCGTGTCAACATCCTGGGATTTTCCATTTTCAACCAATCCCATGCT
TTCTTCCAAGAGTTTGCCCAGAGCCTCAACCAGTCCTGGCAGGAGAACTGTGACCATGTGCCCTTCACTGGGCCTGCGCTCTCCTCGGCC
CTGCTGTTTGATGCTGTCTATGCTGTGGTGACTGCGGTGCAGGAACTGAACCGGAGCCAAGAGATCGGCGTGAAGCCCTTGTCCTGCGGC
TCGGCCCAGATCTGGCAGCACGGCACCAGCCTCATGAACTACCTGCGCATGGTAGAATTGGAAGGTCTTACCGGCCACATTGAATTCAAC
AGCAAAGGCCAGAGGTCCAACTACGCTTTGAAAATCTTACAGTTCACAAGGAATGGTTTTCGGCAGATCGGCCAGTGGCACGTGGCAGAG
GGCCTCAGCATGGACAGCCACCTCTATGCCTCCAACATCTCGGACACTCTCTTCAACACCACCCTGGTCGTCACCACCATCCTGGAGAAC
CCATATTTAATGCTGAAGGGGAACCACCAGGAGATGGAAGGCAATGACCGCTACGAGGGCTTCTGTGTGGACATGCTCAAGGAGCTGGCA
GAGATCCTCCGATTCAACTACAAGATCCGCCTGGTTGGGGATGGCGTGTACGGCGTTCCCGAGGCCAACGGCACCTGGACGGGAATGGTC
GGGGAGCTGATCGCTAGGGATCCTGACAGTGATCAACCTCTGAACAGCCTCGATGTCAAACCCCTGCGCAAACCCCGTATCCCCATGGAG
ACCTTCAGAAAGGTGGGGATCCCCATCATCATAGCACTACTGAGCCTGGCGAGTATCATCATTGTGGTTGTCCTCATCAAGGTGATTCTG
GATAAATACTACTTCCTCTGCGGGCAGCCTCTCCACTTCATCCCGAGGAAGCAGCTGTGTGACGGAGAGCTGGACTGTCCCTTGGGGGAG
GACGAGGAGCACTGTGTCAAGAGCTTCCCCGAAGGGCCTGCAGTGGCAGTCCGCCTCTCCAAGGACCGATCCACACTGCAGGTGCTGGAC
TCGGCCACAGGGAACTGGTTCTCTGCCTGTTTCGACAACTTCACAGAAGCTCTCGCTGAGACAGCCTGTAGGCAGATGGGCTACAGCAGC
AAACCCACTTTCAGAGCTGTGGAGATTGGCCCAGACCAGGATCTGGATGTTGTTGAAATCACAGAAAACAGCCAGGAGCTTCGCATGCGG
AACTCAAGTGGGCCCTGTCTCTCAGGCTCCCTGGTCTCCCTGCACTGTCTTGCCTGTGGGAAGAGCCTGAAGACCCCCCGTGTGGTGGGT
GTGGAGGAGGCCTCTGTGGATTCTTGGCCTTGGCAGGTCAGCATCCAGTACGACAAACAGCACGTCTGTGGAGGGAGCATCCTGGACCCC
CACTGGGTCCTCACGGCAGCCCACTGCTTCAGGAAACATACCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGC
TTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAG
TTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATT
GGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAAT
GCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGT
GGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCGTTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGA
GTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGA
GCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGC
CTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCCTCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGC
TCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCACTGAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTT
TCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGCCCAGATCACTGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCT
GTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAACCAGTTGTAATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTA
CCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTATTAAAGAGCTGTGTAACATCTCTGGCATAGGCTAGCTGGAATGCTTGATA
AGAACTGAGCTGGGATGATTGAACTTTCATTCTTTGGCTTGGGGAGAAAAGAAGTCCTGGGGAAGCAATTGAGTCTCAAAGTAGAGGCAG
GGGAAAAAAGAGTTAGGGAGACCAGATCTGCTGAGTGGCAGCAAGAGTGAGCTGCAGATTACAGAAACCAGGGTGAGCAAGTTTGAGTCC
CACACAGGGCCTTCTCCCTTTGCCTCTTTCCCTCCCTCCCTGCCTGTGATAATCAGCCAGGAGCCAGGGATAACCTATGACTTGGGAAAG
AGATGAGTTAGGCAGTCAAGGGTGACATTCAATCAGGGATCCACAAGTGGCTGGAAAGAAATGCTGGTCCTGTGTCCTAACTTTTTCCGC
CTGGAGAGCCCTCAGTGTGGCTTCTTACATTTAAAAAACAAAAAGGATCAGCTGCCAGGTGTGAGGCAGTCCCCAAGCTGAGTTGTGAGG
ATGTAAGCATGAATAAGTCCCTGCACTCAAAATGGTCAAAGAATTAAACCCCATGGACTTTTTTGGCATCTGTATGAAAGCTTGGGTTTT
CTGAGGACTGTCTTGCTATAGTTAAGTCAGATCCTAGATGAAATATACTTGTTCATACTGTACTAGGTTCTTAGGAAACAACAGAATTCC
TCAAATGCCAAAAACAAAGAAAATAGAAACCCAGAAAACAAAACAAAATAAAACAAAACCATCAGAACTGTGAGTGGAAACTAAGGTGAT
GATCTGGGAGCAATACACTAAAATCTTGGGTCGAGACCTATATGAAGGCTGGCAGTGGAGCTAAACCTGGACACACTGAAGACAAGGGAG
CTGAACCAGGGCTCCTACATGAAGCAGGGATAACTGATGGCAGTAAATGTGGTCTCAAATTGCAGATGGTCTGGAGGAAAATTTCCCAAA
TTTAGAGCCTCAGGATTCCCAAAGATCCTCCAAATATGAGCTCACAATCAAAGATCAGAGACGTTGAAAAATAAAAAACACCTTAAGTGG
GCAGCATAAAAAACAGCTAATTTAGAACCCCAAAGGCTTCAGATGTCAGAATATTAGAGACTTATGATAATAAGCAATATTTGCAGAGTA
TTTGTATGTGCCAGACACTATTGTAAGTGCTTCATCATGTACTGATTCATTTAATACTCACAGAAATCTGTGAGATGGGTATTATTCTTA
TCCTCACTCTATGGATTAAAAAAACTAAGGCACAAAGTGGTTAAGCTCCTTGCCTGAGATTATAGACTGTAAGTTGAACGTGAGCACTTG
GAATACAGAGTTCATGCTGTAAACTACCACACTATAGGGCCTCCAATATGATAATTTATAAAATATTTGAATAAAAAATGAATACTAGTT
CCACATTTTAAAATCATGTTTAACTGTGGTCAAATGCACATAACACAAGTTGCCATCTTCACCATTTTTAGGTGTATAGTTCAGTGGTGT
TATGTACATTCACACTATTGTGCAGTCATCACCACCATCCATCTCCAGAACAGAAACTCAGTACCCATCAAACAACTCTCCATTTCCCCC
TCCTCCCAATCTCTGGCAACCACCATTGTGCTTTCAGTCTCTGTGAACTGGATTACTCTGGGTACCTCATTTAAGTGAAGTCATGCAGTA
TTGGTCTTTTTGTACTTGTTTTATTTCACTTCACATTGTGTCTTCAAGTTTCACCCATGTTGTAGCATGTGTCAGAATTTCTTCCCTTTT
TAGACTAAATAATATTCTATTGTTTATACGAACATTCAGGTTACTTCTATCTTTTGGCTATTGTGAATTATGCTGCTGTGAACATGGGTG
TACAAGTATCTCTTTGAGGCCCTGCTTTCAATTCTCTTGGGTATATTCCCAGAAGTGGAATTGCTGGATCATATGGTAATTCTATTTTGA
ATTTTTTGAGGAACTGATATATTGCTTTCCATAGAGACTGCACCATTTTACATTCCCATCAACAGTTTGCAGGAGTTACTATTTCTCCAT
ATCCCCCCTAACACTTGCTATTTTCTGTTAAAAATGGATATCTTAATAATCAAGCAAAAATAACAGGCAGATTTGAAAAAGAACTGAATA
CAGCTTTTAGAAATAAAAACTATAATTATAAAAATAAAAAACTAAGTGGATGGGGTAAATAACAATTAAAACACCAATTAAGAGAGAACA
AATGAACTGGAAGATAAATTGAAGAAGTGACTAGGCTTAACAGCAGAGAGAGATAAGGAGATTAAAAATATGAAAACAAGGCCAGGAGCA
ATGAAGCCTAGAATGGTAAATTCTAACATATCCAGAATCCCAGAAAGAGAGAATCAAGACAATGAGAGAGAGACAGTACCAAAGAGATAA
GAGCTGAGAATGTTCCAGAATTGATAAAAGGTGTGAATCCACAGAACATACACCACCATAGTGTACACGCATACAACCAAGGTGGAAAAA
TTAGAATAAATCCACACCTATGTACATTATAATGAAACTGCAGAACACCAAAGACAAAAAGAAACTCCTTATAGCAGCAGAGAGAAAACC
CAGACCACCCACAGTACCACAAATCTACCACAATTAGACTGACAACAGGCTTTCCCACAGCAATAAAGGAGCTAGAAGTCAGTGGAAGTA
TATCTCCAGCATGCCAAAAGATAACAATCAATCAGGGATTGTGAACCCTACAAAACTATCTTTCAAGAATAAAGGCATTTTCAAGAAAAC
AAAAACAGACTTTACCATCAACAAACCTTCTCTAAAAGAATATATAAAGCATTTACTTTAGGAAGAAGGAAAATGATCCTAAAAGGAAGA
ACCAAGAAGCAAGTAGCAATAGTGAGGCAATTGTGAAAATGTAGGTAAGTCTAAACACACTCTGTCTACTTCTTCTTCTTCTTCTTCTTC
TTCTTCTTCTTATTTTGAGACTGAGTCTTGCCCTGTCACCCAGACTGGAGTGCAGTGGCAGGATCTTGGCTCACTGCTATCTCCACCTCC
CAGGTTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACATGCACATGCCACCATATCCGGCTAATTTTTGAATTTTTAG
TAGAGATGGGGTTTCACTGTGTTGGCCAGGCCGGTCTCAAACTCCCGACCTCAAGTGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGA
TTACAGGCGTGTCTACATATTATTAAAATAACAATAATATTTATTTTGTGGGTTAATTTTTTTTGAAACAGATATTGAATTTATTGGTTG
GCTATGAGTAGAAAAATACATCAGTAAAGAAAAAAGACCCTGTATATAAATATAATACTAGCTAGTTAAAATTTGACCAAGAAGTTTCCA

>34797_34797_1_GRIK4-TMPRSS4_GRIK4_chr11_120776202_ENST00000438375_TMPRSS4_chr11_117965537_ENST00000534111_length(amino acids)=926AA_BP=492
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKG
VVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSI
FNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVD
MLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVV
LIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACR
QMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCG
GSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA
TPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCG

--------------------------------------------------------------
>34797_34797_2_GRIK4-TMPRSS4_GRIK4_chr11_120776202_ENST00000527524_TMPRSS4_chr11_117965537_ENST00000534111_length(transcript)=7045nt_BP=1763nt
AGCTGCGGGCGGATCGGGCTGGAGCCGCCACGGCTGCTGCGGAAGAGGAAAAACGGCCAACAGCAGCCCCGCGGCCGGCCCGGCAGCGCC
CGGCCCCCGGCTCAGCCCCCGGAGTGCGGAGCCGACCAGCAGATACTTTCTGAGTGCCTACTATGTGCCAGCCTGTGCTAGGCACTGAGG
ACACAGGTGGAAAAGCCCGAATTGCTCCCTGCTCTCCTGGCGCTCATCACCCCGGAGAGTTATGTCATGCCCAGGCCAGCAGGGGGCTCC
ATGAGGATTCATAGAAGATGCCCCGCGTCTCGGCGCCTTTGGTGCTGCTTCCTGCGTGGCTCGTGATGGTCGCCTGCAGCCCGCACTCCT
TGAGGATCGCTGCTATCTTGGACGACCCCATGGAGTGCAGCAGAGGGGAGCGGCTCTCCATCACCCTGGCCAAGAACCGCATCAACCGCG
CTCCTGAGAGGCTGGGCAAGGCCAAGGTCGAAGTGGACATCTTTGAGCTTCTCAGAGACAGCGAGTACGAGACTGCAGAAACCATGTGTC
AGATCCTCCCCAAGGGGGTGGTCGCTGTCCTCGGACCATCGTCCAGCCCAGCCTCCAGCTCCATCATCAGCAACATCTGTGGAGAGAAGG
AGGTCCCTCACTTCAAAGTGGCCCCAGAGGAGTTCGTCAAGTTCCAGTTCCAGAGATTCACAACCCTGAACCTCCACCCCAGCAACACTG
ACATCAGCGTGGCTGTAGCTGGGATCCTGAACTTCTTCAACTGCACCACCGCCTGCCTCATCTGTGCCAAAGCAGAATGCCTTTTAAACC
TAGAGAAGCTGCTCCGGCAATTCCTTATCTCCAAGGACACGCTGTCCGTCCGCATGCTGGATGACACCCGGGACCCCACCCCGCTCCTCA
AGGAGATCCGGGACGACAAGACCGCCACCATCATCATCCACGCCAACGCCTCCATGTCCCACACCATCCTCCTGAAGGCAGCCGAACTTG
GGATGGTGTCAGCCTATTACACATACATCTTCACTAATCTGGAGTTCTCACTCCAGAGAATGGACAGCCTTGTGGATGATCGTGTCAACA
TCCTGGGATTTTCCATTTTCAACCAATCCCATGCTTTCTTCCAAGAGTTTGCCCAGAGCCTCAACCAGTCCTGGCAGGAGAACTGTGACC
ATGTGCCCTTCACTGGGCCTGCGCTCTCCTCGGCCCTGCTGTTTGATGCTGTCTATGCTGTGGTGACTGCGGTGCAGGAACTGAACCGGA
GCCAAGAGATCGGCGTGAAGCCCTTGTCCTGCGGCTCGGCCCAGATCTGGCAGCACGGCACCAGCCTCATGAACTACCTGCGCATGGTAG
AATTGGAAGGTCTTACCGGCCACATTGAATTCAACAGCAAAGGCCAGAGGTCCAACTACGCTTTGAAAATCTTACAGTTCACAAGGAATG
GTTTTCGGCAGATCGGCCAGTGGCACGTGGCAGAGGGCCTCAGCATGGACAGCCACCTCTATGCCTCCAACATCTCGGACACTCTCTTCA
ACACCACCCTGGTCGTCACCACCATCCTGGAGAACCCATATTTAATGCTGAAGGGGAACCACCAGGAGATGGAAGGCAATGACCGCTACG
AGGGCTTCTGTGTGGACATGCTCAAGGAGCTGGCAGAGATCCTCCGATTCAACTACAAGATCCGCCTGGTTGGGGATGGCGTGTACGGCG
TTCCCGAGGCCAACGGCACCTGGACGGGAATGGTCGGGGAGCTGATCGCTAGGGATCCTGACAGTGATCAACCTCTGAACAGCCTCGATG
TCAAACCCCTGCGCAAACCCCGTATCCCCATGGAGACCTTCAGAAAGGTGGGGATCCCCATCATCATAGCACTACTGAGCCTGGCGAGTA
TCATCATTGTGGTTGTCCTCATCAAGGTGATTCTGGATAAATACTACTTCCTCTGCGGGCAGCCTCTCCACTTCATCCCGAGGAAGCAGC
TGTGTGACGGAGAGCTGGACTGTCCCTTGGGGGAGGACGAGGAGCACTGTGTCAAGAGCTTCCCCGAAGGGCCTGCAGTGGCAGTCCGCC
TCTCCAAGGACCGATCCACACTGCAGGTGCTGGACTCGGCCACAGGGAACTGGTTCTCTGCCTGTTTCGACAACTTCACAGAAGCTCTCG
CTGAGACAGCCTGTAGGCAGATGGGCTACAGCAGCAAACCCACTTTCAGAGCTGTGGAGATTGGCCCAGACCAGGATCTGGATGTTGTTG
AAATCACAGAAAACAGCCAGGAGCTTCGCATGCGGAACTCAAGTGGGCCCTGTCTCTCAGGCTCCCTGGTCTCCCTGCACTGTCTTGCCT
GTGGGAAGAGCCTGAAGACCCCCCGTGTGGTGGGTGTGGAGGAGGCCTCTGTGGATTCTTGGCCTTGGCAGGTCAGCATCCAGTACGACA
AACAGCACGTCTGTGGAGGGAGCATCCTGGACCCCCACTGGGTCCTCACGGCAGCCCACTGCTTCAGGAAACATACCGATGTGTTCAACT
GGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCATGTACC
CCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCTTTGATG
AGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGCTGCAGG
CGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAGGCATCC
CGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCGTTAGTT
GGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGAAGGCTG
AGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACACAGAGC
AAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCCTCGCAG
CCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCACTGAACAA
GGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGCCCAGATCACTGTGGG
CTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAACCAGTTGTAATATAA
AATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTATTAAAGAGCTGTGTA
ACATCTCTGGCATAGGCTAGCTGGAATGCTTGATAAGAACTGAGCTGGGATGATTGAACTTTCATTCTTTGGCTTGGGGAGAAAAGAAGT
CCTGGGGAAGCAATTGAGTCTCAAAGTAGAGGCAGGGGAAAAAAGAGTTAGGGAGACCAGATCTGCTGAGTGGCAGCAAGAGTGAGCTGC
AGATTACAGAAACCAGGGTGAGCAAGTTTGAGTCCCACACAGGGCCTTCTCCCTTTGCCTCTTTCCCTCCCTCCCTGCCTGTGATAATCA
GCCAGGAGCCAGGGATAACCTATGACTTGGGAAAGAGATGAGTTAGGCAGTCAAGGGTGACATTCAATCAGGGATCCACAAGTGGCTGGA
AAGAAATGCTGGTCCTGTGTCCTAACTTTTTCCGCCTGGAGAGCCCTCAGTGTGGCTTCTTACATTTAAAAAACAAAAAGGATCAGCTGC
CAGGTGTGAGGCAGTCCCCAAGCTGAGTTGTGAGGATGTAAGCATGAATAAGTCCCTGCACTCAAAATGGTCAAAGAATTAAACCCCATG
GACTTTTTTGGCATCTGTATGAAAGCTTGGGTTTTCTGAGGACTGTCTTGCTATAGTTAAGTCAGATCCTAGATGAAATATACTTGTTCA
TACTGTACTAGGTTCTTAGGAAACAACAGAATTCCTCAAATGCCAAAAACAAAGAAAATAGAAACCCAGAAAACAAAACAAAATAAAACA
AAACCATCAGAACTGTGAGTGGAAACTAAGGTGATGATCTGGGAGCAATACACTAAAATCTTGGGTCGAGACCTATATGAAGGCTGGCAG
TGGAGCTAAACCTGGACACACTGAAGACAAGGGAGCTGAACCAGGGCTCCTACATGAAGCAGGGATAACTGATGGCAGTAAATGTGGTCT
CAAATTGCAGATGGTCTGGAGGAAAATTTCCCAAATTTAGAGCCTCAGGATTCCCAAAGATCCTCCAAATATGAGCTCACAATCAAAGAT
CAGAGACGTTGAAAAATAAAAAACACCTTAAGTGGGCAGCATAAAAAACAGCTAATTTAGAACCCCAAAGGCTTCAGATGTCAGAATATT
AGAGACTTATGATAATAAGCAATATTTGCAGAGTATTTGTATGTGCCAGACACTATTGTAAGTGCTTCATCATGTACTGATTCATTTAAT
ACTCACAGAAATCTGTGAGATGGGTATTATTCTTATCCTCACTCTATGGATTAAAAAAACTAAGGCACAAAGTGGTTAAGCTCCTTGCCT
GAGATTATAGACTGTAAGTTGAACGTGAGCACTTGGAATACAGAGTTCATGCTGTAAACTACCACACTATAGGGCCTCCAATATGATAAT
TTATAAAATATTTGAATAAAAAATGAATACTAGTTCCACATTTTAAAATCATGTTTAACTGTGGTCAAATGCACATAACACAAGTTGCCA
TCTTCACCATTTTTAGGTGTATAGTTCAGTGGTGTTATGTACATTCACACTATTGTGCAGTCATCACCACCATCCATCTCCAGAACAGAA
ACTCAGTACCCATCAAACAACTCTCCATTTCCCCCTCCTCCCAATCTCTGGCAACCACCATTGTGCTTTCAGTCTCTGTGAACTGGATTA
CTCTGGGTACCTCATTTAAGTGAAGTCATGCAGTATTGGTCTTTTTGTACTTGTTTTATTTCACTTCACATTGTGTCTTCAAGTTTCACC
CATGTTGTAGCATGTGTCAGAATTTCTTCCCTTTTTAGACTAAATAATATTCTATTGTTTATACGAACATTCAGGTTACTTCTATCTTTT
GGCTATTGTGAATTATGCTGCTGTGAACATGGGTGTACAAGTATCTCTTTGAGGCCCTGCTTTCAATTCTCTTGGGTATATTCCCAGAAG
TGGAATTGCTGGATCATATGGTAATTCTATTTTGAATTTTTTGAGGAACTGATATATTGCTTTCCATAGAGACTGCACCATTTTACATTC
CCATCAACAGTTTGCAGGAGTTACTATTTCTCCATATCCCCCCTAACACTTGCTATTTTCTGTTAAAAATGGATATCTTAATAATCAAGC
AAAAATAACAGGCAGATTTGAAAAAGAACTGAATACAGCTTTTAGAAATAAAAACTATAATTATAAAAATAAAAAACTAAGTGGATGGGG
TAAATAACAATTAAAACACCAATTAAGAGAGAACAAATGAACTGGAAGATAAATTGAAGAAGTGACTAGGCTTAACAGCAGAGAGAGATA
AGGAGATTAAAAATATGAAAACAAGGCCAGGAGCAATGAAGCCTAGAATGGTAAATTCTAACATATCCAGAATCCCAGAAAGAGAGAATC
AAGACAATGAGAGAGAGACAGTACCAAAGAGATAAGAGCTGAGAATGTTCCAGAATTGATAAAAGGTGTGAATCCACAGAACATACACCA
CCATAGTGTACACGCATACAACCAAGGTGGAAAAATTAGAATAAATCCACACCTATGTACATTATAATGAAACTGCAGAACACCAAAGAC
AAAAAGAAACTCCTTATAGCAGCAGAGAGAAAACCCAGACCACCCACAGTACCACAAATCTACCACAATTAGACTGACAACAGGCTTTCC
CACAGCAATAAAGGAGCTAGAAGTCAGTGGAAGTATATCTCCAGCATGCCAAAAGATAACAATCAATCAGGGATTGTGAACCCTACAAAA
CTATCTTTCAAGAATAAAGGCATTTTCAAGAAAACAAAAACAGACTTTACCATCAACAAACCTTCTCTAAAAGAATATATAAAGCATTTA
CTTTAGGAAGAAGGAAAATGATCCTAAAAGGAAGAACCAAGAAGCAAGTAGCAATAGTGAGGCAATTGTGAAAATGTAGGTAAGTCTAAA
CACACTCTGTCTACTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTATTTTGAGACTGAGTCTTGCCCTGTCACCCAGACTGGAGTGCAG
TGGCAGGATCTTGGCTCACTGCTATCTCCACCTCCCAGGTTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACATGCAC
ATGCCACCATATCCGGCTAATTTTTGAATTTTTAGTAGAGATGGGGTTTCACTGTGTTGGCCAGGCCGGTCTCAAACTCCCGACCTCAAG
TGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTCTACATATTATTAAAATAACAATAATATTTATTTTGTGGGTTA
ATTTTTTTTGAAACAGATATTGAATTTATTGGTTGGCTATGAGTAGAAAAATACATCAGTAAAGAAAAAAGACCCTGTATATAAATATAA
TACTAGCTAGTTAAAATTTGACCAAGAAGTTTCCATTGTGGGTTAATTTTTAAAGGCCTAACTGAAATATGGAGTAACCACAGCATGCAG

>34797_34797_2_GRIK4-TMPRSS4_GRIK4_chr11_120776202_ENST00000527524_TMPRSS4_chr11_117965537_ENST00000534111_length(amino acids)=926AA_BP=492
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKG
VVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSI
FNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVD
MLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVV
LIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACR
QMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCG
GSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA
TPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRIK4-TMPRSS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRIK4-TMPRSS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRIK4-TMPRSS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource