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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRIN2A-CPPED1 (FusionGDB2 ID:34802)

Fusion Gene Summary for GRIN2A-CPPED1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRIN2A-CPPED1
Fusion gene ID: 34802
HgeneTgene
Gene symbol

GRIN2A

CPPED1

Gene ID

2903

55313

Gene nameglutamate ionotropic receptor NMDA type subunit 2Acalcineurin like phosphoesterase domain containing 1
SynonymsEPND|FESD|GluN2A|LKS|NMDAR2A|NR2ACSTP1
Cytomap

16p13.2

16p13.12

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, NMDA 2AN-methyl D-aspartate receptor subtype 2AN-methyl-D-aspartate receptor channel, subunit epsilon-1N-methyl-D-aspartate receptor subunit 2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2Aserine/threonine-protein phosphatase CPPED1calcineurin-like phosphoesterase domain-containing protein 1complete S-transactivated protein 1
Modification date2020031320200313
UniProtAcc

Q12879

Q9BRF8

Ensembl transtripts involved in fusion geneENST00000330684, ENST00000396573, 
ENST00000396575, ENST00000404927, 
ENST00000535259, ENST00000562109, 
ENST00000566670, 		ENST00000261660, 
ENST00000433677, ENST00000381774, 
Fusion gene scores* DoF score8 X 7 X 5=2807 X 7 X 4=196
# samples 77
** MAII scorelog2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRIN2A [Title/Abstract] AND CPPED1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRIN2A(9934504)-CPPED1(12798906), # samples:1
Anticipated loss of major functional domain due to fusion event.GRIN2A-CPPED1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GRIN2A-CPPED1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GRIN2A-CPPED1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GRIN2A-CPPED1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRIN2A

GO:0045471

response to ethanol

18445116

HgeneGRIN2A

GO:0097553

calcium ion transmembrane import into cytosol

26875626


check buttonFusion gene breakpoints across GRIN2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CPPED1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DG-A2KH-01AGRIN2Achr16

9934504

-CPPED1chr16

12798906

-


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Fusion Gene ORF analysis for GRIN2A-CPPED1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000330684ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000330684ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000396573ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000396573ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000396575ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000396575ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000404927ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000404927ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000535259ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000535259ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000562109ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
5CDS-intronENST00000562109ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
Frame-shiftENST00000330684ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
Frame-shiftENST00000396573ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
Frame-shiftENST00000404927ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
Frame-shiftENST00000535259ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
In-frameENST00000396575ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
In-frameENST00000562109ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
intron-3CDSENST00000566670ENST00000381774GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
intron-intronENST00000566670ENST00000261660GRIN2Achr16

9934504

-CPPED1chr16

12798906

-
intron-intronENST00000566670ENST00000433677GRIN2Achr16

9934504

-CPPED1chr16

12798906

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000562109GRIN2Achr169934504-ENST00000381774CPPED1chr1612798906-41521672212327768
ENST00000396575GRIN2Achr169934504-ENST00000381774CPPED1chr1612798906-4131165102306768

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000562109ENST00000381774GRIN2Achr169934504-CPPED1chr1612798906-0.0012624780.9987375
ENST00000396575ENST00000381774GRIN2Achr169934504-CPPED1chr1612798906-0.0012347970.99876523

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Fusion Genomic Features for GRIN2A-CPPED1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRIN2A-CPPED1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:9934504/chr16:12798906)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRIN2A

Q12879

CPPED1

Q9BRF8

FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:Q00959, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}.FUNCTION: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269|PubMed:23799035, ECO:0000269|PubMed:23939394}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713511_5135501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814511_5135501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612511_5135501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714511_5135501282.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613511_5135501282.0RegionGlutamate binding
TgeneCPPED1chr16:9934504chr16:12798906ENST000004336770347_2500173.0RegionNote=Catalytic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713601_6205501465.0IntramembraneDiscontinuously helical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814601_6205501465.0IntramembraneDiscontinuously helical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612601_6205501465.0IntramembraneDiscontinuously helical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714601_6205501282.0IntramembraneDiscontinuously helical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613601_6205501282.0IntramembraneDiscontinuously helical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-7131462_14645501465.0MotifPDZ-binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-8141462_14645501465.0MotifPDZ-binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-6121462_14645501465.0MotifPDZ-binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-7141462_14645501282.0MotifPDZ-binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-6131462_14645501282.0MotifPDZ-binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713599_6205501465.0RegionPore-forming
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713689_6905501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713730_7315501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814599_6205501465.0RegionPore-forming
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814689_6905501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814730_7315501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612599_6205501465.0RegionPore-forming
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612689_6905501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612730_7315501465.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714599_6205501282.0RegionPore-forming
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714689_6905501282.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714730_7315501282.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613599_6205501282.0RegionPore-forming
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613689_6905501282.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613730_7315501282.0RegionGlutamate binding
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-71323_5555501465.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713577_6005501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713621_6255501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713646_8165501465.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713838_14645501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-81423_5555501465.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814577_6005501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814621_6255501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814646_8165501465.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814838_14645501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-61223_5555501465.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612577_6005501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612621_6255501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612646_8165501465.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612838_14645501465.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-71423_5555501282.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714577_6005501282.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714621_6255501282.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714646_8165501282.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714838_14645501282.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-61323_5555501282.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613577_6005501282.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613621_6255501282.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613646_8165501282.0Topological domainExtracellular
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613838_14645501282.0Topological domainCytoplasmic
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713556_5765501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713626_6455501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000330684-713817_8375501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814556_5765501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814626_6455501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396573-814817_8375501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612556_5765501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612626_6455501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000396575-612817_8375501465.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714556_5765501282.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714626_6455501282.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000404927-714817_8375501282.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613556_5765501282.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613626_6455501282.0TransmembraneHelical
HgeneGRIN2Achr16:9934504chr16:12798906ENST00000562109-613817_8375501282.0TransmembraneHelical
TgeneCPPED1chr16:9934504chr16:12798906ENST000003817741447_25096315.0RegionNote=Catalytic


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Fusion Gene Sequence for GRIN2A-CPPED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34802_34802_1_GRIN2A-CPPED1_GRIN2A_chr16_9934504_ENST00000396575_CPPED1_chr16_12798906_ENST00000381774_length(transcript)=4131nt_BP=1651nt
ATGGGCAGAGTGGGCTATTGGACCCTGCTGGTGCTGCCGGCCCTTCTGGTCTGGCGCGGTCCGGCGCCGAGCGCGGCGGCGGAGAAGGGT
CCCCCCGCGCTAAATATTGCGGTGATGCTGGGTCACAGCCACGACGTGACAGAGCGCGAACTTCGAACACTGTGGGGCCCCGAGCAGGCG
GCGGGGCTGCCCCTGGACGTGAACGTGGTAGCTCTGCTGATGAACCGCACCGACCCCAAGAGCCTCATCACGCACGTGTGCGACCTCATG
TCCGGGGCACGCATCCACGGCCTCGTGTTTGGGGACGACACGGACCAGGAGGCCGTAGCCCAGATGCTGGATTTTATCTCCTCCCACACC
TTCGTCCCCATCTTGGGCATTCATGGGGGCGCATCTATGATCATGGCTGACAAGGATCCGACGTCTACCTTCTTCCAGTTTGGAGCGTCC
ATCCAGCAGCAAGCCACGGTCATGCTGAAGATCATGCAGGATTATGACTGGCATGTCTTCTCCCTGGTGACCACTATCTTCCCTGGCTAC
AGGGAATTCATCAGCTTCGTCAAGACCACAGTGGACAACAGCTTTGTGGGCTGGGACATGCAGAATGTGATCACACTGGACACTTCCTTT
GAGGATGCAAAGACACAAGTCCAGCTGAAGAAGATCCACTCTTCTGTCATCTTGCTCTACTGTTCCAAAGACGAGGCTGTTCTCATTCTG
AGTGAGGCCCGCTCCCTTGGCCTCACCGGGTATGATTTCTTCTGGATTGTCCCCAGCTTGGTCTCTGGGAACACGGAGCTCATCCCAAAA
GAGTTTCCATCGGGACTCATTTCTGTCTCCTACGATGACTGGGACTACAGCCTGGAGGCGAGAGTGAGGGACGGCATTGGCATCCTAACC
ACCGCTGCATCTTCTATGCTGGAGAAGTTCTCCTACATCCCCGAGGCCAAGGCCAGCTGCTACGGGCAGATGGAGAGGCCAGAGGTCCCG
ATGCACACCTTGCACCCATTTATGGTCAATGTTACATGGGATGGCAAAGACTTATCCTTCACTGAGGAAGGCTACCAGGTGCACCCCAGG
CTGGTGGTGATTGTGCTGAACAAAGACCGGGAATGGGAAAAGGTGGGCAAGTGGGAGAACCATACGCTGAGCCTGAGGCACGCCGTGTGG
CCCAGGTACAAGTCCTTCTCCGACTGTGAGCCGGATGACAACCATCTCAGCATCGTCACCCTGGAGGAGGCCCCATTCGTCATCGTGGAA
GACATAGACCCCCTGACCGAGACGTGTGTGAGGAACACCGTGCCATGTCGGAAGTTCGTCAAAATCAACAATTCAACCAATGAGGGGATG
AATGTGAAGAAATGCTGCAAGGGGTTCTGCATTGATATTCTGAAGAAGCTTTCCAGAACTGTGAAGTTTACTTACGACCTCTATCTGGTG
ACCAATGGGAAGCATGGCAAGAAAGTTAACAATGTGTGGAATGGAATGATCGGTGAAGTGGTCTATCAACGGGCAGTCATGGCAGTTGGC
TCGCTCACCATCAATGAGGAACGTTCTGAAGTGGTGGACTTCTCTGTGCCCTTTGTGGAAACGGGAATCAGTGTCATGGTTTCAAGAAGT
AATGGCACCGTCTCACCTTCTGCTTTTCTAGGGAAGCCGTGGCGGACGGAGCAGACGGAGGACCTGAAGCGAGTGCTTAGGGCAGTGGAC
AGGGCCATCCCACTGGTCCTTGTCAGCGGCAACCATGACATTGGCAACACCCCCACGGCCGAGACCGTCGAGGAGTTCTGCCGGACTTGG
GGAGATGACTACTTCAGCTTCTGGGTCGGGGGCGTCCTGTTCCTGGTCCTCAACTCCCAGTTCTACGAGAACCCCTCCAAATGCCCCAGC
CTGAAGCAGGCTCAGGACCAGTGGCTGGACGAGCAGCTGAGCATCGCGAGGCAGCGGCACTGCCAGCATGCCATCGTCTTCCAGCACATC
CCGCTGTTCCTGGAGAGCATCGACGAGGACGACGACTACTACTTCAACCTCAGCAAGTCCACTCGGAAGAAGTTGGCAGACAAGTTCATC
CACGCAGGTGTCAAAGTCGTGTTCTCAGGCCACTACCACAGGAATGCCGGGGGTACCTACCAGAACCTCGACATGGTGGTGTCATCTGCC
ATTGGATGCCAGCTGGGCAGAGACCCCCACGGGCTCCGAGTCGTGGTGGTCACCGCCGAGAAAATTGTTCACCGATACTACAGTCTAGAT
GAGCTGAGTGAGAAAGGAATAGAAGACGATCTCATGGATTTGATCAAGAAAAAATGACGCTCCTTCCCGTTCCCGTTCACTTTTCACTTG
CACTATTTTTTTATTTTGCCAGAAACAGCAGCTGCACACAACCTCTTGCTGAAATATAAAAATAGCCCAGGCAGGTTTGTGAATTTATGT
CCTTTTGCATAAATCAGAGAGCTGGGGCCCTGTCCTGAATTATATTCAAAATAGAACTGCATTTCCTTTAAAATGGAGCGAATGATCCTG
GAAATCAGTTTTTAAAATATTAGACTATCTCTGCATGGATGTTTGAATAAATTCTCCTAATGCTGTGTTTCTCAACTCCACTTTTGAATT
GGATTGTATTCTGGTTAGCATATGGTCAAAGTCTGCCTATCGACCTCAATTCCAATCTGACAGCCAAGTATGATCTTTGATAATTCCTTA
AACAAACTACACCTGATTGTATTAAATTGTGGTCACGATTCCCAAAACGCTAGGCAAAACAAAGTTCATCTCCTTTCCTTTCCAGCGGAA
CGAACAGCTGTCTCCCTTGTTGTGAGAGCCATGCAGACTTATTTTGACAAGGAGCCAAGTAGGCACCATTTACTGTTCAATTCTGAGACT
TCTGATGATAGGAACAGAATGCAGTTGATACAGCTCGGAGCTTAAATTTGCCTTCCTGGGTGCCTAGAAAAGTCACCTTTGCACATAAAT
TGGCCATTTCTGAAAATCTCCTCCAAGAGACTGAAACCAAAGCTCTAAAACGCCGCTTCTTCAGTCTCTGGGGAGCACGTTGAGTTGGTT
CACATCCACATTCTGGCTGTGTAGCCACTCCACAGATGGGTGGTCTCTTGGGATCAGAATGCCCCTCCACTCATGAGACTCTTCATTTTG
TCCACTTTGACAGGAAAAGTGGGAATGTATGCAGAGCTCTCAAAAGAAACAAAAAAGGCCAAAACGGTGCCTTCAGCCACATCCTCTGAA
TTGGCCCTGACTTGGACTAAATGCACTAATGCAAAATCCCTTGACAAAAGCGCATAGGTTATTTCAAACCAGCATTGTTTTTTATGTAAC
CTGTTTTACCGCATCTTCTCAGCAGCTTCTGACCACTGCTCAATTTTCTCCTTTACAGCCATTGTTCTGGTGGACAAATAACCTAGGTAC
TCCAAATCCTGGCAGGAAAAATATACAGCATTATGAAACAGCACTCAGTAATCCTAAAATGATTTCCAAAGCTGGTTACACATGACCTGC
AAAGTCTATTAAATTAAAAGACTTTCTCATTACAGAGTTTAGTCAACGTAGCAAAACCATGGGAAATTAAATGGAAAGATAATTAAATAT
GTAAATTCATAAGGAACAAAAGACGAGAAGTTAATTATACAATAGGCTGGTGACACCAGAGTTCATTGTTATGTGCCACAAGAAAATTAA
ATTTTTTAAAAAACTAGAACGCTCTTCTTTTAGTGTTTTGCTGAAATCCTGTTTTGTATTTGTTTCTTTACAACAGGTGTAGGTATAGGA
GGTCAAGAAAAGGAGTTCGGTAAAGGGCATAGCTAATAACAACCACACATTGGGCCAGGCACAGTGGCTTACGCCTGTAATCCCAGCACT
TTGGGAGGCTGAGACGGGCAGATCACCTGAGATCAGGAGTTTGAGAACAGCCTGGCCAACATGGTGAAACTCCATCTCTACTAAAAATAC
AAAAATTAGCCAGGCATGCTGGTGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGATCGCTGGAACTCAGGAGGCAGAGG

>34802_34802_1_GRIN2A-CPPED1_GRIN2A_chr16_9934504_ENST00000396575_CPPED1_chr16_12798906_ENST00000381774_length(amino acids)=768AA_BP=550
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLM
SGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPK
EFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGM
NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPS
LKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSA

--------------------------------------------------------------
>34802_34802_2_GRIN2A-CPPED1_GRIN2A_chr16_9934504_ENST00000562109_CPPED1_chr16_12798906_ENST00000381774_length(transcript)=4152nt_BP=1672nt
CAGGGACCGTCAGTGGCGACTATGGGCAGAGTGGGCTATTGGACCCTGCTGGTGCTGCCGGCCCTTCTGGTCTGGCGCGGTCCGGCGCCG
AGCGCGGCGGCGGAGAAGGGTCCCCCCGCGCTAAATATTGCGGTGATGCTGGGTCACAGCCACGACGTGACAGAGCGCGAACTTCGAACA
CTGTGGGGCCCCGAGCAGGCGGCGGGGCTGCCCCTGGACGTGAACGTGGTAGCTCTGCTGATGAACCGCACCGACCCCAAGAGCCTCATC
ACGCACGTGTGCGACCTCATGTCCGGGGCACGCATCCACGGCCTCGTGTTTGGGGACGACACGGACCAGGAGGCCGTAGCCCAGATGCTG
GATTTTATCTCCTCCCACACCTTCGTCCCCATCTTGGGCATTCATGGGGGCGCATCTATGATCATGGCTGACAAGGATCCGACGTCTACC
TTCTTCCAGTTTGGAGCGTCCATCCAGCAGCAAGCCACGGTCATGCTGAAGATCATGCAGGATTATGACTGGCATGTCTTCTCCCTGGTG
ACCACTATCTTCCCTGGCTACAGGGAATTCATCAGCTTCGTCAAGACCACAGTGGACAACAGCTTTGTGGGCTGGGACATGCAGAATGTG
ATCACACTGGACACTTCCTTTGAGGATGCAAAGACACAAGTCCAGCTGAAGAAGATCCACTCTTCTGTCATCTTGCTCTACTGTTCCAAA
GACGAGGCTGTTCTCATTCTGAGTGAGGCCCGCTCCCTTGGCCTCACCGGGTATGATTTCTTCTGGATTGTCCCCAGCTTGGTCTCTGGG
AACACGGAGCTCATCCCAAAAGAGTTTCCATCGGGACTCATTTCTGTCTCCTACGATGACTGGGACTACAGCCTGGAGGCGAGAGTGAGG
GACGGCATTGGCATCCTAACCACCGCTGCATCTTCTATGCTGGAGAAGTTCTCCTACATCCCCGAGGCCAAGGCCAGCTGCTACGGGCAG
ATGGAGAGGCCAGAGGTCCCGATGCACACCTTGCACCCATTTATGGTCAATGTTACATGGGATGGCAAAGACTTATCCTTCACTGAGGAA
GGCTACCAGGTGCACCCCAGGCTGGTGGTGATTGTGCTGAACAAAGACCGGGAATGGGAAAAGGTGGGCAAGTGGGAGAACCATACGCTG
AGCCTGAGGCACGCCGTGTGGCCCAGGTACAAGTCCTTCTCCGACTGTGAGCCGGATGACAACCATCTCAGCATCGTCACCCTGGAGGAG
GCCCCATTCGTCATCGTGGAAGACATAGACCCCCTGACCGAGACGTGTGTGAGGAACACCGTGCCATGTCGGAAGTTCGTCAAAATCAAC
AATTCAACCAATGAGGGGATGAATGTGAAGAAATGCTGCAAGGGGTTCTGCATTGATATTCTGAAGAAGCTTTCCAGAACTGTGAAGTTT
ACTTACGACCTCTATCTGGTGACCAATGGGAAGCATGGCAAGAAAGTTAACAATGTGTGGAATGGAATGATCGGTGAAGTGGTCTATCAA
CGGGCAGTCATGGCAGTTGGCTCGCTCACCATCAATGAGGAACGTTCTGAAGTGGTGGACTTCTCTGTGCCCTTTGTGGAAACGGGAATC
AGTGTCATGGTTTCAAGAAGTAATGGCACCGTCTCACCTTCTGCTTTTCTAGGGAAGCCGTGGCGGACGGAGCAGACGGAGGACCTGAAG
CGAGTGCTTAGGGCAGTGGACAGGGCCATCCCACTGGTCCTTGTCAGCGGCAACCATGACATTGGCAACACCCCCACGGCCGAGACCGTC
GAGGAGTTCTGCCGGACTTGGGGAGATGACTACTTCAGCTTCTGGGTCGGGGGCGTCCTGTTCCTGGTCCTCAACTCCCAGTTCTACGAG
AACCCCTCCAAATGCCCCAGCCTGAAGCAGGCTCAGGACCAGTGGCTGGACGAGCAGCTGAGCATCGCGAGGCAGCGGCACTGCCAGCAT
GCCATCGTCTTCCAGCACATCCCGCTGTTCCTGGAGAGCATCGACGAGGACGACGACTACTACTTCAACCTCAGCAAGTCCACTCGGAAG
AAGTTGGCAGACAAGTTCATCCACGCAGGTGTCAAAGTCGTGTTCTCAGGCCACTACCACAGGAATGCCGGGGGTACCTACCAGAACCTC
GACATGGTGGTGTCATCTGCCATTGGATGCCAGCTGGGCAGAGACCCCCACGGGCTCCGAGTCGTGGTGGTCACCGCCGAGAAAATTGTT
CACCGATACTACAGTCTAGATGAGCTGAGTGAGAAAGGAATAGAAGACGATCTCATGGATTTGATCAAGAAAAAATGACGCTCCTTCCCG
TTCCCGTTCACTTTTCACTTGCACTATTTTTTTATTTTGCCAGAAACAGCAGCTGCACACAACCTCTTGCTGAAATATAAAAATAGCCCA
GGCAGGTTTGTGAATTTATGTCCTTTTGCATAAATCAGAGAGCTGGGGCCCTGTCCTGAATTATATTCAAAATAGAACTGCATTTCCTTT
AAAATGGAGCGAATGATCCTGGAAATCAGTTTTTAAAATATTAGACTATCTCTGCATGGATGTTTGAATAAATTCTCCTAATGCTGTGTT
TCTCAACTCCACTTTTGAATTGGATTGTATTCTGGTTAGCATATGGTCAAAGTCTGCCTATCGACCTCAATTCCAATCTGACAGCCAAGT
ATGATCTTTGATAATTCCTTAAACAAACTACACCTGATTGTATTAAATTGTGGTCACGATTCCCAAAACGCTAGGCAAAACAAAGTTCAT
CTCCTTTCCTTTCCAGCGGAACGAACAGCTGTCTCCCTTGTTGTGAGAGCCATGCAGACTTATTTTGACAAGGAGCCAAGTAGGCACCAT
TTACTGTTCAATTCTGAGACTTCTGATGATAGGAACAGAATGCAGTTGATACAGCTCGGAGCTTAAATTTGCCTTCCTGGGTGCCTAGAA
AAGTCACCTTTGCACATAAATTGGCCATTTCTGAAAATCTCCTCCAAGAGACTGAAACCAAAGCTCTAAAACGCCGCTTCTTCAGTCTCT
GGGGAGCACGTTGAGTTGGTTCACATCCACATTCTGGCTGTGTAGCCACTCCACAGATGGGTGGTCTCTTGGGATCAGAATGCCCCTCCA
CTCATGAGACTCTTCATTTTGTCCACTTTGACAGGAAAAGTGGGAATGTATGCAGAGCTCTCAAAAGAAACAAAAAAGGCCAAAACGGTG
CCTTCAGCCACATCCTCTGAATTGGCCCTGACTTGGACTAAATGCACTAATGCAAAATCCCTTGACAAAAGCGCATAGGTTATTTCAAAC
CAGCATTGTTTTTTATGTAACCTGTTTTACCGCATCTTCTCAGCAGCTTCTGACCACTGCTCAATTTTCTCCTTTACAGCCATTGTTCTG
GTGGACAAATAACCTAGGTACTCCAAATCCTGGCAGGAAAAATATACAGCATTATGAAACAGCACTCAGTAATCCTAAAATGATTTCCAA
AGCTGGTTACACATGACCTGCAAAGTCTATTAAATTAAAAGACTTTCTCATTACAGAGTTTAGTCAACGTAGCAAAACCATGGGAAATTA
AATGGAAAGATAATTAAATATGTAAATTCATAAGGAACAAAAGACGAGAAGTTAATTATACAATAGGCTGGTGACACCAGAGTTCATTGT
TATGTGCCACAAGAAAATTAAATTTTTTAAAAAACTAGAACGCTCTTCTTTTAGTGTTTTGCTGAAATCCTGTTTTGTATTTGTTTCTTT
ACAACAGGTGTAGGTATAGGAGGTCAAGAAAAGGAGTTCGGTAAAGGGCATAGCTAATAACAACCACACATTGGGCCAGGCACAGTGGCT
TACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACGGGCAGATCACCTGAGATCAGGAGTTTGAGAACAGCCTGGCCAACATGGTGAAA
CTCCATCTCTACTAAAAATACAAAAATTAGCCAGGCATGCTGGTGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGATCG
CTGGAACTCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAAA

>34802_34802_2_GRIN2A-CPPED1_GRIN2A_chr16_9934504_ENST00000562109_CPPED1_chr16_12798906_ENST00000381774_length(amino acids)=768AA_BP=550
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLM
SGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPK
EFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGM
NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPS
LKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRIN2A-CPPED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRIN2A-CPPED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRIN2A-CPPED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource