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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRK6-DBN1 (FusionGDB2 ID:34892)

Fusion Gene Summary for GRK6-DBN1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRK6-DBN1
Fusion gene ID: 34892
HgeneTgene
Gene symbol

GRK6

DBN1

Gene ID

2870

1627

Gene nameG protein-coupled receptor kinase 6drebrin 1
SynonymsGPRK6D0S117E
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
DescriptionG protein-coupled receptor kinase 6drebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2
Modification date2020031320200320
UniProtAcc

P43250

Q16643

Ensembl transtripts involved in fusion geneENST00000355472, ENST00000355958, 
ENST00000393576, ENST00000507633, 
ENST00000528793, 		ENST00000292385, 
ENST00000309007, ENST00000393563, 
ENST00000393565, ENST00000512501, 
Fusion gene scores* DoF score5 X 4 X 5=10010 X 9 X 7=630
# samples 810
** MAII scorelog2(8/100*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRK6 [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRK6(176862122)-DBN1(176886269), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDBN1

GO:0051220

cytoplasmic sequestering of protein

28966017


check buttonFusion gene breakpoints across GRK6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DBN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MH-01AGRK6chr5

176862122

-DBN1chr5

176886269

-
ChimerDB4STADTCGA-CD-A4MH-01AGRK6chr5

176862122

+DBN1chr5

176886269

-
ChimerDB4STADTCGA-CD-A4MHGRK6chr5

176862122

+DBN1chr5

176886269

-


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Fusion Gene ORF analysis for GRK6-DBN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000355472ENST00000292385GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355472ENST00000309007GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355472ENST00000393563GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355472ENST00000393565GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355472ENST00000512501GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355958ENST00000292385GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355958ENST00000309007GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355958ENST00000393563GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355958ENST00000393565GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000355958ENST00000512501GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000393576ENST00000292385GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000393576ENST00000309007GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000393576ENST00000393563GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000393576ENST00000393565GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000393576ENST00000512501GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000507633ENST00000292385GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000507633ENST00000309007GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000507633ENST00000393563GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000507633ENST00000393565GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000507633ENST00000512501GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000528793ENST00000292385GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000528793ENST00000309007GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000528793ENST00000393563GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000528793ENST00000393565GRK6chr5

176862122

+DBN1chr5

176886269

-
In-frameENST00000528793ENST00000512501GRK6chr5

176862122

+DBN1chr5

176886269

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GRK6-DBN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRK6-DBN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176862122/chr5:176886269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRK6

P43250

DBN1

Q16643

FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.FUNCTION: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+111653_171352577.0DomainRGS
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+111653_171352561.0DomainRGS
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+111653_171352590.0DomainRGS
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+1116192_200352577.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+1116264_270352577.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+1116315_318352577.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+1116192_200352561.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+1116264_270352561.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+1116315_318352561.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+1116192_200352590.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+1116264_270352590.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+1116315_318352590.0Nucleotide bindingNote=ATP
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+11161_185352577.0RegionNote=N-terminal
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+11161_185352561.0RegionNote=N-terminal
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+11161_185352590.0RegionNote=N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+1116186_448352577.0DomainProtein kinase
HgeneGRK6chr5:176862122chr5:176886269ENST00000355472+1116449_514352577.0DomainAGC-kinase C-terminal
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+1116186_448352561.0DomainProtein kinase
HgeneGRK6chr5:176862122chr5:176886269ENST00000355958+1116449_514352561.0DomainAGC-kinase C-terminal
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+1116186_448352590.0DomainProtein kinase
HgeneGRK6chr5:176862122chr5:176886269ENST00000528793+1116449_514352590.0DomainAGC-kinase C-terminal
TgeneDBN1chr5:176862122chr5:176886269ENST0000029238510153_134320652.0DomainADF-H
TgeneDBN1chr5:176862122chr5:176886269ENST000003090079143_134318650.0DomainADF-H
TgeneDBN1chr5:176862122chr5:176886269ENST0000039356510153_134364696.0DomainADF-H


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Fusion Gene Sequence for GRK6-DBN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRK6-DBN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRK6-DBN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRK6-DBN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource