FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GRM3-CASR (FusionGDB2 ID:34900)

Fusion Gene Summary for GRM3-CASR

check button Fusion gene summary
Fusion gene informationFusion gene name: GRM3-CASR
Fusion gene ID: 34900
HgeneTgene
Gene symbol

GRM3

CASR

Gene ID

2913

846

Gene nameglutamate metabotropic receptor 3calcium sensing receptor
SynonymsGLUR3|GPRC1C|MGLUR3|mGlu3CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1|hCasR
Cytomap

7q21.11-q21.12

3q13.33-q21.1

Type of geneprotein-codingprotein-coding
Descriptionmetabotropic glutamate receptor 3glutamate receptor, metabotropic 3extracellular calcium-sensing receptorparathyroid Ca(2+)-sensing receptor 1parathyroid cell calcium-sensing receptor 1
Modification date2020031320200313
UniProtAcc

Q14832

P41180

Ensembl transtripts involved in fusion geneENST00000361669, ENST00000394720, 
ENST00000439827, ENST00000536043, 
ENST00000546348, 		ENST00000296154, 
ENST00000490131, ENST00000498619, 
Fusion gene scores* DoF score4 X 5 X 1=208 X 9 X 7=504
# samples 515
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRM3 [Title/Abstract] AND CASR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRM3(86479793)-CASR(122003403), # samples:1
Anticipated loss of major functional domain due to fusion event.GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GRM3-CASR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASR

GO:0005513

detection of calcium ion

27434672

TgeneCASR

GO:0006874

cellular calcium ion homeostasis

27434672

TgeneCASR

GO:0007186

G protein-coupled receptor signaling pathway

27434672

TgeneCASR

GO:0070509

calcium ion import

20846291


check buttonFusion gene breakpoints across GRM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAX542233GRM3chr7

86479793

+CASRchr3

122003403

+


Top

Fusion Gene ORF analysis for GRM3-CASR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361669ENST00000296154GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000361669ENST00000490131GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000394720ENST00000296154GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000394720ENST00000490131GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000394720ENST00000498619GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000439827ENST00000296154GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000439827ENST00000490131GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000439827ENST00000498619GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000536043ENST00000296154GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000536043ENST00000490131GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000546348ENST00000296154GRM3chr7

86479793

+CASRchr3

122003403

+
Frame-shiftENST00000546348ENST00000490131GRM3chr7

86479793

+CASRchr3

122003403

+
In-frameENST00000361669ENST00000498619GRM3chr7

86479793

+CASRchr3

122003403

+
In-frameENST00000536043ENST00000498619GRM3chr7

86479793

+CASRchr3

122003403

+
In-frameENST00000546348ENST00000498619GRM3chr7

86479793

+CASRchr3

122003403

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361669GRM3chr786479793+ENST00000498619CASRchr3122003403+54963557105441911045
ENST00000546348GRM3chr786479793+ENST00000498619CASRchr3122003403+355616173742251625
ENST00000536043GRM3chr786479793+ENST00000498619CASRchr3122003403+416622271532861902

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361669ENST00000498619GRM3chr786479793+CASRchr3122003403+0.0006526370.9993474
ENST00000546348ENST00000498619GRM3chr786479793+CASRchr3122003403+0.0016233090.9983767
ENST00000536043ENST00000498619GRM3chr786479793+CASRchr3122003403+0.0010735240.99892646

Top

Fusion Genomic Features for GRM3-CASR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GRM3-CASR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:86479793/chr3:122003403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRM3

Q14832

CASR

P41180

FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.FUNCTION: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). {ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406189_32401079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr7:86479793chr3:122003403ENST000002961540622_18801079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406415_41701079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406542_61201079.0RegionCysteine-rich (CR)
TgeneCASRchr7:86479793chr3:122003403ENST000002961540666_7001079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107189_32401079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr7:86479793chr3:122003403ENST000004901310722_18801079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107415_41701079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107542_61201079.0RegionCysteine-rich (CR)
TgeneCASRchr7:86479793chr3:122003403ENST000004901310766_7001079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST000002961540620_61201079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406636_64901079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406671_68101079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406701_72401079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406746_76901079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406793_80501079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406829_83601079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406863_107801079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST000004901310720_61201079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107636_64901079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107671_68101079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107701_72401079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107746_76901079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107793_80501079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107829_83601079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107863_107801079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406613_63501079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406650_67001079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406682_70001079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406725_74501079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406770_79201079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406806_82801079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406837_86201079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107613_63501079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107650_67001079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107682_70001079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107725_74501079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107770_79201079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107806_82801079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107837_86201079.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16172_1740880.0RegionGlutamate binding
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15172_1740536.0RegionGlutamate binding
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15172_1740538.0RegionGlutamate binding
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+1623_5760880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16600_6130880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16635_6450880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16665_6880880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16710_7340880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16757_7690880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16793_8020880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16829_8790880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+1523_5760536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15600_6130536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15635_6450536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15665_6880536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15710_7340536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15757_7690536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15793_8020536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15829_8790536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+1523_5760538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15600_6130538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15635_6450538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15665_6880538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15710_7340538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15757_7690538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15793_8020538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15829_8790538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16577_5990880.0TransmembraneHelical%3B Name%3D1
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16614_6340880.0TransmembraneHelical%3B Name%3D2
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16646_6640880.0TransmembraneHelical%3B Name%3D3
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16689_7090880.0TransmembraneHelical%3B Name%3D4
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16735_7560880.0TransmembraneHelical%3B Name%3D5
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16770_7920880.0TransmembraneHelical%3B Name%3D6
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16803_8280880.0TransmembraneHelical%3B Name%3D7
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15577_5990536.0TransmembraneHelical%3B Name%3D1
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15614_6340536.0TransmembraneHelical%3B Name%3D2
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15646_6640536.0TransmembraneHelical%3B Name%3D3
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15689_7090536.0TransmembraneHelical%3B Name%3D4
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15735_7560536.0TransmembraneHelical%3B Name%3D5
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15770_7920536.0TransmembraneHelical%3B Name%3D6
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15803_8280536.0TransmembraneHelical%3B Name%3D7
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15577_5990538.0TransmembraneHelical%3B Name%3D1
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15614_6340538.0TransmembraneHelical%3B Name%3D2
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15646_6640538.0TransmembraneHelical%3B Name%3D3
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15689_7090538.0TransmembraneHelical%3B Name%3D4
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15735_7560538.0TransmembraneHelical%3B Name%3D5
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15770_7920538.0TransmembraneHelical%3B Name%3D6
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15803_8280538.0TransmembraneHelical%3B Name%3D7


Top

Fusion Gene Sequence for GRM3-CASR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34900_34900_1_GRM3-CASR_GRM3_chr7_86479793_ENST00000361669_CASR_chr3_122003403_ENST00000498619_length(transcript)=5496nt_BP=3557nt
GTGCAGTTGAGTCGCGAGTACGGCTGAGCTGCGTACCGGCCTCCCTGGCTCTCACACTCCCTCTCTGCTCCCGCTCTCCTAATCTCCTCT
GGCATGCGGTCAGCCCCCTGCCCAGGGACCACAGGAGAGTTCTTGTAAGGACTGTTAGTCCCTGCTTACCTGAAAGCCAAGCGCTCTAGC
AGAGCTTTAAAGTTGGAGCCGCCACCCTCCCTACCGCCCCATGCCCCTTCACCCCACTCCGAAATTCACCGACCTTTGCATGCACTGCCT
AAGGATTTCAGAGTGAGGCAAAGCAGTCGGCAAATCTACCCTGGCTTTTCGTATAAAAATCCTCTCGTCTAGGTACCCTGGCTCACTGAA
GACTCTGCAGATATACCCTTATAAGAGGGAGGGTGGGGGAGGGAAAAGAACGAGAGAGGGAGGAAAGAATGAAAAGGAGAGGATGCCAGG
AGGTCCGTGCTTCTGCCAAGAGTCCCAATTAGATGCGACGGCTTCAGCCTGGTCAAGGTGAAGGAAAGTTGCTTCCGCGCCTAGGAAGTG
GGTTTGCCTGATAAGAGAAGGAGGAGGGGACTCGGCTGGGAAGAGCTCCCCTCCCCTCCGCGGAAGACCACTGGGTCCCCTCTTTCCCCA
ACCTCCTCCCTCTCTTCTACTCCACCCCTCCGTTTTCCCACTCCCCACTGACTCGGATGCCTGGATGTTCTGCCACCGGGCAGTGGTCCA
GCGTGCAGCCGGGAGGGGGCAGGGGCAGGGGGCACTGTGACAGGAAGCTGCGCGCACAAGTTGGCCATTTCGAGGGCAAAATAAGTTCTC
CCTTGGATTTGGAAAGGACAAAGCCAGTAAGCTACCTCTTTTGTGTCGGATGAGGAGGACCAACCATGAGCCAGAGCCCGGGTGCAGGCT
CACCGCCGCCGCTGCCACCGCGGTCAGCTCCAGTTCCTGCCAGGAGTTGTCGGTGCGAGGAATTTTGTGACAGGCTCTGTTAGTCTGTTC
CTCCCTTATTTGAAGGACAGGCCAAAGATCCAGTTTGGAAATGAGAGAGGACTAGCATGACACATTGGCTCCACCATTGATATCTCCCAG
AGGTACAGAAACAGGATTCATGAAGATGTTGACAAGACTGCAAGTTCTTACCTTAGCTTTGTTTTCAAAGGGATTTTTACTCTCTTTAGG
GGACCATAACTTTCTAAGGAGAGAGATTAAAATAGAAGGTGACCTTGTTTTAGGGGGCCTGTTTCCTATTAACGAAAAAGGCACTGGAAC
TGAAGAATGTGGGCGAATCAATGAAGACCGAGGGATTCAACGCCTGGAAGCCATGTTGTTTGCTATTGATGAAATCAACAAAGATGATTA
CTTGCTACCAGGAGTGAAGTTGGGTGTTCACATTTTGGATACATGTTCAAGGGATACCTATGCATTGGAGCAATCACTGGAGTTTGTCAG
GGCATCTTTGACAAAAGTGGATGAAGCTGAGTATATGTGTCCTGATGGATCCTATGCCATTCAAGAAAACATCCCACTTCTCATTGCAGG
GGTCATTGGTGGCTCTTATAGCAGTGTTTCCATACAGGTGGCAAACCTGCTGCGGCTCTTCCAGATCCCTCAGATCAGCTACGCATCCAC
CAGCGCCAAACTCAGTGATAAGTCGCGCTATGATTACTTTGCCAGGACCGTGCCCCCCGACTTCTACCAGGCCAAAGCCATGGCTGAGAT
CTTGCGCTTCTTCAACTGGACCTACGTGTCCACAGTAGCCTCCGAGGGTGATTACGGGGAGACAGGGATCGAGGCCTTCGAGCAGGAAGC
CCGCCTGCGCAACATCTGCATCGCTACGGCGGAGAAGGTGGGCCGCTCCAACATCCGCAAGTCCTACGACAGCGTGATCCGAGAACTGTT
GCAGAAGCCCAACGCGCGCGTCGTGGTCCTCTTCATGCGCAGCGACGACTCGCGGGAGCTCATTGCAGCCGCCAGCCGCGCCAATGCCTC
CTTCACCTGGGTGGCCAGCGACGGCTGGGGCGCGCAGGAGAGCATCATCAAGGGCAGCGAGCATGTGGCCTACGGCGCCATCACCCTGGA
GCTGGCCTCCCAGCCTGTCCGCCAGTTCGACCGCTACTTCCAGAGCCTCAACCCCTACAACAACCACCGCAACCCCTGGTTCCGGGACTT
CTGGGAGCAAAAGTTTCAGTGCAGCCTCCAGAACAAACGCAACCACAGGCGCGTCTGCGACAAGCACCTGGCCATCGACAGCAGCAACTA
CGAGCAAGAGTCCAAGATCATGTTTGTGGTGAACGCGGTGTATGCCATGGCCCACGCTTTGCACAAAATGCAGCGCACCCTCTGTCCCAA
CACTACCAAGCTTTGTGATGCTATGAAGATCCTGGATGGGAAGAAGTTGTACAAGGATTACTTGCTGAAAATCAACTTCACGGCTCCATT
CAACCCAAATAAAGATGCAGATAGCATAGTCAAGTTTGACACTTTTGGAGATGGAATGGGGCGATACAACGTGTTCAATTTCCAAAATGT
AGGTGGAAAGTATTCCTACTTGAAAGTTGGTCACTGGGCAGAAACCTTATCGCTAGATGTCAACTCTATCCACTGGTCCCGGAACTCAGT
CCCCACTTCCCAGTGCAGCGACCCCTGTGCCCCCAATGAAATGAAGAATATGCAACCAGGGGATGTCTGCTGCTGGATTTGCATCCCCTG
TGAACCCTACGAATACCTGGCTGATGAGTTTACCTGTATGGATTGTGGGTCTGGACAGTGGCCCACTGCAGACCTAACTGGATGCTATGA
CCTTCCTGAGGACTACATCAGGTGGGAAGACGCCTGGGCCATTGGCCCAGTCACCATTGCCTGTCTGGGTTTTATGTGTACATGCATGGT
TGTAACTGTTTTTATCAAGCACAACAACACACCCTTGGTCAAAGCATCGGGCCGAGAACTCTGCTACATCTTATTGTTTGGGGTTGGCCT
GTCATACTGCATGACATTCTTCTTCATTGCCAAGCCATCACCAGTCATCTGTGCATTGCGCCGACTCGGGCTGGGGAGTTCCTTCGCTAT
CTGTTACTCAGCCCTGCTGACCAAGACAAACTGCATTGCCCGCATCTTCGATGGGGTCAAGAATGGCGCTCAGAGGCCAAAATTCATCAG
CCCCAGTTCTCAGGTTTTCATCTGCCTGGGTCTGATCCTGGTGCAAATTGTGATGGTGTCTGTGTGGCTCATCCTGGAGGCCCCAGGCAC
CAGGAGGTATACCCTTGCAGAGAAGCGGGAAACAGTCATCCTAAAATGCAATGTCAAAGATTCCAGCATGTTGATCTCTCTTACCTACGA
TGTGATCCTGGTGATCTTATGCACTGTGTACGCCTTCAAAACGCGGAAGTGCCCAGAAAATTTCAACGAAGCTAAGTTCATAGGTTTTAC
CATGTACACCACGTGCATCATCTGGTTGGCCTTCCTCCCTATATTTTATGTGACATCAAGTGACTACAGAGTTGTCACACACAGACTGCA
CCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCATCGAGGAGGTGCGTTGCAGCACCGCAGCTCACGCTTTCAA
GGTGGCTGCCCGGGCCACGCTGCGCCGCAGCAACGTCTCCCGCAAGCGGTCCAGCAGCCTTGGAGGCTCCACGGGATCCACCCCCTCCTC
CTCCATCAGCAGCAAGAGCAACAGCGAAGACCCATTCCCACAGCCCGAGAGGCAGAAGCAGCAGCAGCCGCTGGCCCTAACCCAGCAAGA
GCAGCAGCAGCAGCCCCTGACCCTCCCACAGCAGCAACGATCTCAGCAGCAGCCCAGATGCAAGCAGAAGGTCATCTTTGGCAGCGGCAC
GGTCACCTTCTCACTGAGCTTTGATGAGCCTCAGAAGAACGCCATGGCCCACAGGAATTCTACGCACCAGAACTCCCTGGAGGCCCAGAA
AAGCAGCGATACGCTGACCCGACACGAGCCATTACTCCCGCTGCAGTGCGGGGAAACGGACTTAGATCTGACCGTCCAGGAAACAGGTCT
GCAAGGACCTGTGGGTGGAGACCAGCGGCCAGAGGTGGAGGACCCTGAAGAGTTGTCCCCAGCACTTGTAGTGTCCAGTTCACAGAGCTT
TGTCATCAGTGGTGGAGGCAGCACTGTTACAGAAAACGTAGTGAATTCATAAAATGGAAGGAGAAGACTGGGCTAGGGAGAATGCAGAGA
GGTTTCTTGGGGTCCCAGGGAAGAGGAATCGCCCCAGACTCCTTTCCTCTGAGGAAGAAGGGATAATAGACACATCAAATGCCCCGAATT
TAGTCACACCATCTTAAATGACAGTGAATTGACCCATGTTCCCTTTAAAATTAAAAAAAAGAAGAGCCTTGTGTTTCTGTGGTTGCATTT
GTCAAAGCATTGAGATCTCCACGGTCAGATTTGCTGTTCACCCACATCTAATGTCTCTTCCTCTGTTCTATCCCACCCAACAGCTCAGAG
ATGAAACTATGGCTTTAAACTACCCTCCAGAGTGTGCAGACTGATGGGACATCAAATTTGCCACCACTAGAGCTGAGAGTCTGAAAGACA
GAATGTCACCAGTCCTGCCCAATGCCTTGACAACAGACTGAATTTTAAATGTTCACAACATAAGGAGAATGTATCTCCTCCTATTTATGA
AAACCATATGATATTTTGTCTCCTACCTGCTGCTGCTATTATGTAACATCCAGAAGGTTTGCACCCCTCCTATACCATATGTCTGCTTCT
GTCCAGGACATGATACTGATGCCATGTTTAGATTCCAGGATCACAAGAATCACCTCAAATTGTTAGGAAGGGACTGCATAAACCAATGAG
CTGTATCTGTAATTAATATTCCTATATGTAGCTTTATCCTTAGGAAAATGCTTCTGTTGTAATAGTCCATGGACAATATAAACTGAAAAA
TGTCAGTCTGGTTTATATAAGGCAGTATTATTGAGCTCTATTTCCCCACCCCACTATCCTCACTCCCATAAGCTAAGCCTTATGTGAGCC
CCTTCAGGGACTCAAGGGTCCAGAAGTCCCTCCCATCTCTACCCCAAAGAATTCCTGAAGCCAGATCCACCCTATCCCTGTACAGAGTAA
GTTCTCAATTATTGGCCTGCTAATAGCTGCTAGGGTAGGAAAGCGTGGTTCCAAGAAAGATCCACCCTCAAATGTCAGAGCTATGTTCCC
TCCAGCAGTGGTATTAATACTGCCGGTCACCCAGGCTCTGGAGCCAGAGAGACAGACCGGGGTTCAAGCCATGGCTTCGTCATTTGCAAG
CTGAGTGACTGTAGGCAGGGAACCTTAACCTCTCTAAGCCACAGCTTCTTCATCTTTAAAATAAGGATAATAATCATTCTTTCCCCTCAG
AGCTCTTATGTGGATTAAACGAGATAATGTATATAAAGTACTTTAGCCTGGTACCTAGCACACAATAAGCATTCAATAAATATTAGTTAA

>34900_34900_1_GRM3-CASR_GRM3_chr7_86479793_ENST00000361669_CASR_chr3_122003403_ENST00000498619_length(amino acids)=1045AA_BP=769
MAPPLISPRGTETGFMKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFA
IDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQ
IPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKS
YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNN
HRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYL
LKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGD
VCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELC
YILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSV
WLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD
YRVVTHRLHLNRFSVSGTGTTYSQSIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQ
QPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDL

--------------------------------------------------------------
>34900_34900_2_GRM3-CASR_GRM3_chr7_86479793_ENST00000536043_CASR_chr3_122003403_ENST00000498619_length(transcript)=4166nt_BP=2227nt
GTGCAGCCGGGAGGGGGCAGGGGCAGGGGGCACTGTGACAGGAAGCTGCGCGCACAAGTTGGCCATTTCGAGGGCAAAATAAGTTCTCCC
TTGGATTTGGAAAGGACAAAGCCAGTAAGCTACCTCTTTTGTGTCGGATGAGGAGGACCAACCATGAGCCAGAGCCCGGGTGCAGGCTCA
CCGCCGCCGCTGCCACCGCGGTCAGCTCCAGTTCCTGCCAGGAGTTGTCGGTGCGAGGTGGCAAACCTGCTGCGGCTCTTCCAGATCCCT
CAGATCAGCTACGCATCCACCAGCGCCAAACTCAGTGATAAGTCGCGCTATGATTACTTTGCCAGGACCGTGCCCCCCGACTTCTACCAG
GCCAAAGCCATGGCTGAGATCTTGCGCTTCTTCAACTGGACCTACGTGTCCACAGTAGCCTCCGAGGGTGATTACGGGGAGACAGGGATC
GAGGCCTTCGAGCAGGAAGCCCGCCTGCGCAACATCTGCATCGCTACGGCGGAGAAGGTGGGCCGCTCCAACATCCGCAAGTCCTACGAC
AGCGTGATCCGAGAACTGTTGCAGAAGCCCAACGCGCGCGTCGTGGTCCTCTTCATGCGCAGCGACGACTCGCGGGAGCTCATTGCAGCC
GCCAGCCGCGCCAATGCCTCCTTCACCTGGGTGGCCAGCGACGGCTGGGGCGCGCAGGAGAGCATCATCAAGGGCAGCGAGCATGTGGCC
TACGGCGCCATCACCCTGGAGCTGGCCTCCCAGCCTGTCCGCCAGTTCGACCGCTACTTCCAGAGCCTCAACCCCTACAACAACCACCGC
AACCCCTGGTTCCGGGACTTCTGGGAGCAAAAGTTTCAGTGCAGCCTCCAGAACAAACGCAACCACAGGCGCGTCTGCGACAAGCACCTG
GCCATCGACAGCAGCAACTACGAGCAAGAGTCCAAGATCATGTTTGTGGTGAACGCGGTGTATGCCATGGCCCACGCTTTGCACAAAATG
CAGCGCACCCTCTGTCCCAACACTACCAAGCTTTGTGATGCTATGAAGATCCTGGATGGGAAGAAGTTGTACAAGGATTACTTGCTGAAA
ATCAACTTCACGGCTCCATTCAACCCAAATAAAGATGCAGATAGCATAGTCAAGTTTGACACTTTTGGAGATGGAATGGGGCGATACAAC
GTGTTCAATTTCCAAAATGTAGGTGGAAAGTATTCCTACTTGAAAGTTGGTCACTGGGCAGAAACCTTATCGCTAGATGTCAACTCTATC
CACTGGTCCCGGAACTCAGTCCCCACTTCCCAGTGCAGCGACCCCTGTGCCCCCAATGAAATGAAGAATATGCAACCAGGGGATGTCTGC
TGCTGGATTTGCATCCCCTGTGAACCCTACGAATACCTGGCTGATGAGTTTACCTGTATGGATTGTGGGTCTGGACAGTGGCCCACTGCA
GACCTAACTGGATGCTATGACCTTCCTGAGGACTACATCAGGTGGGAAGACGCCTGGGCCATTGGCCCAGTCACCATTGCCTGTCTGGGT
TTTATGTGTACATGCATGGTTGTAACTGTTTTTATCAAGCACAACAACACACCCTTGGTCAAAGCATCGGGCCGAGAACTCTGCTACATC
TTATTGTTTGGGGTTGGCCTGTCATACTGCATGACATTCTTCTTCATTGCCAAGCCATCACCAGTCATCTGTGCATTGCGCCGACTCGGG
CTGGGGAGTTCCTTCGCTATCTGTTACTCAGCCCTGCTGACCAAGACAAACTGCATTGCCCGCATCTTCGATGGGGTCAAGAATGGCGCT
CAGAGGCCAAAATTCATCAGCCCCAGTTCTCAGGTTTTCATCTGCCTGGGTCTGATCCTGGTGCAAATTGTGATGGTGTCTGTGTGGCTC
ATCCTGGAGGCCCCAGGCACCAGGAGGTATACCCTTGCAGAGAAGCGGGAAACAGTCATCCTAAAATGCAATGTCAAAGATTCCAGCATG
TTGATCTCTCTTACCTACGATGTGATCCTGGTGATCTTATGCACTGTGTACGCCTTCAAAACGCGGAAGTGCCCAGAAAATTTCAACGAA
GCTAAGTTCATAGGTTTTACCATGTACACCACGTGCATCATCTGGTTGGCCTTCCTCCCTATATTTTATGTGACATCAAGTGACTACAGA
GTTGTCACACACAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCATCGAGGAGGTGCGTTGCAGC
ACCGCAGCTCACGCTTTCAAGGTGGCTGCCCGGGCCACGCTGCGCCGCAGCAACGTCTCCCGCAAGCGGTCCAGCAGCCTTGGAGGCTCC
ACGGGATCCACCCCCTCCTCCTCCATCAGCAGCAAGAGCAACAGCGAAGACCCATTCCCACAGCCCGAGAGGCAGAAGCAGCAGCAGCCG
CTGGCCCTAACCCAGCAAGAGCAGCAGCAGCAGCCCCTGACCCTCCCACAGCAGCAACGATCTCAGCAGCAGCCCAGATGCAAGCAGAAG
GTCATCTTTGGCAGCGGCACGGTCACCTTCTCACTGAGCTTTGATGAGCCTCAGAAGAACGCCATGGCCCACAGGAATTCTACGCACCAG
AACTCCCTGGAGGCCCAGAAAAGCAGCGATACGCTGACCCGACACGAGCCATTACTCCCGCTGCAGTGCGGGGAAACGGACTTAGATCTG
ACCGTCCAGGAAACAGGTCTGCAAGGACCTGTGGGTGGAGACCAGCGGCCAGAGGTGGAGGACCCTGAAGAGTTGTCCCCAGCACTTGTA
GTGTCCAGTTCACAGAGCTTTGTCATCAGTGGTGGAGGCAGCACTGTTACAGAAAACGTAGTGAATTCATAAAATGGAAGGAGAAGACTG
GGCTAGGGAGAATGCAGAGAGGTTTCTTGGGGTCCCAGGGAAGAGGAATCGCCCCAGACTCCTTTCCTCTGAGGAAGAAGGGATAATAGA
CACATCAAATGCCCCGAATTTAGTCACACCATCTTAAATGACAGTGAATTGACCCATGTTCCCTTTAAAATTAAAAAAAAGAAGAGCCTT
GTGTTTCTGTGGTTGCATTTGTCAAAGCATTGAGATCTCCACGGTCAGATTTGCTGTTCACCCACATCTAATGTCTCTTCCTCTGTTCTA
TCCCACCCAACAGCTCAGAGATGAAACTATGGCTTTAAACTACCCTCCAGAGTGTGCAGACTGATGGGACATCAAATTTGCCACCACTAG
AGCTGAGAGTCTGAAAGACAGAATGTCACCAGTCCTGCCCAATGCCTTGACAACAGACTGAATTTTAAATGTTCACAACATAAGGAGAAT
GTATCTCCTCCTATTTATGAAAACCATATGATATTTTGTCTCCTACCTGCTGCTGCTATTATGTAACATCCAGAAGGTTTGCACCCCTCC
TATACCATATGTCTGCTTCTGTCCAGGACATGATACTGATGCCATGTTTAGATTCCAGGATCACAAGAATCACCTCAAATTGTTAGGAAG
GGACTGCATAAACCAATGAGCTGTATCTGTAATTAATATTCCTATATGTAGCTTTATCCTTAGGAAAATGCTTCTGTTGTAATAGTCCAT
GGACAATATAAACTGAAAAATGTCAGTCTGGTTTATATAAGGCAGTATTATTGAGCTCTATTTCCCCACCCCACTATCCTCACTCCCATA
AGCTAAGCCTTATGTGAGCCCCTTCAGGGACTCAAGGGTCCAGAAGTCCCTCCCATCTCTACCCCAAAGAATTCCTGAAGCCAGATCCAC
CCTATCCCTGTACAGAGTAAGTTCTCAATTATTGGCCTGCTAATAGCTGCTAGGGTAGGAAAGCGTGGTTCCAAGAAAGATCCACCCTCA
AATGTCAGAGCTATGTTCCCTCCAGCAGTGGTATTAATACTGCCGGTCACCCAGGCTCTGGAGCCAGAGAGACAGACCGGGGTTCAAGCC
ATGGCTTCGTCATTTGCAAGCTGAGTGACTGTAGGCAGGGAACCTTAACCTCTCTAAGCCACAGCTTCTTCATCTTTAAAATAAGGATAA
TAATCATTCTTTCCCCTCAGAGCTCTTATGTGGATTAAACGAGATAATGTATATAAAGTACTTTAGCCTGGTACCTAGCACACAATAAGC

>34900_34900_2_GRM3-CASR_GRM3_chr7_86479793_ENST00000536043_CASR_chr3_122003403_ENST00000498619_length(amino acids)=902AA_BP=626
MSQSPGAGSPPPLPPRSAPVPARSCRCEVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVAS
EGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQES
IIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVY
AMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAE
TLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAI
GPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIAR
IFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKT
RKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVVTHRLHLNRFSVSGTGTTYSQSIEEVRCSTAAHAFKVAARATLRRSNVSR
KRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNA
MAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVV

--------------------------------------------------------------
>34900_34900_3_GRM3-CASR_GRM3_chr7_86479793_ENST00000546348_CASR_chr3_122003403_ENST00000498619_length(transcript)=3556nt_BP=1617nt
AATTAGATGCGACGGCTTCAGCCTGGTCAAGGTGAAGGAAAGTTGCTTCCGCGCCTAGGAAGTGGGTTTGCCTGATAAGAGAAGGAGGAG
GGGACTCGGCTGGGAAGAGCTCCCCTCCCCTCCGCGGAAGACCACTGGGTCCCCTCTTTCCCCAACCTCCTCCCTCTCTTCTACTCCACC
CCTCCGTTTTCCCACTCCCCACTGACTCGGATGCCTGGATGTTCTGCCACCGGGCAGTGGTCCAGCGTGCAGCCGGGAGGGGGCAGGGGC
AGGGGGCACTGTGACAGGAAGCTGCGCGCACAAGTTGGCCATTTCGAGGGCAAAATAAGTTCTCCCTTGGATTTGGAAAGGACAAAGCCA
GTAAGCTACCTCTTTTGTGTCGGATGAGGAGGACCAACCATGAGCCAGAGCCCGGGTGCAGGCTCACCGCCGCCGCTGCCACCGCGGTCA
GCTCCAGTTCCTGCCAGGAGTTGTCGGTGCGAGCTCCATTCAACCCAAATAAAGATGCAGATAGCATAGTCAAGTTTGACACTTTTGGAG
ATGGAATGGGGCGATACAACGTGTTCAATTTCCAAAATGTAGGTGGAAAGTATTCCTACTTGAAAGTTGGTCACTGGGCAGAAACCTTAT
CGCTAGATGTCAACTCTATCCACTGGTCCCGGAACTCAGTCCCCACTTCCCAGTGCAGCGACCCCTGTGCCCCCAATGAAATGAAGAATA
TGCAACCAGGGGATGTCTGCTGCTGGATTTGCATCCCCTGTGAACCCTACGAATACCTGGCTGATGAGTTTACCTGTATGGATTGTGGGT
CTGGACAGTGGCCCACTGCAGACCTAACTGGATGCTATGACCTTCCTGAGGACTACATCAGGTGGGAAGACGCCTGGGCCATTGGCCCAG
TCACCATTGCCTGTCTGGGTTTTATGTGTACATGCATGGTTGTAACTGTTTTTATCAAGCACAACAACACACCCTTGGTCAAAGCATCGG
GCCGAGAACTCTGCTACATCTTATTGTTTGGGGTTGGCCTGTCATACTGCATGACATTCTTCTTCATTGCCAAGCCATCACCAGTCATCT
GTGCATTGCGCCGACTCGGGCTGGGGAGTTCCTTCGCTATCTGTTACTCAGCCCTGCTGACCAAGACAAACTGCATTGCCCGCATCTTCG
ATGGGGTCAAGAATGGCGCTCAGAGGCCAAAATTCATCAGCCCCAGTTCTCAGGTTTTCATCTGCCTGGGTCTGATCCTGGTGCAAATTG
TGATGGTGTCTGTGTGGCTCATCCTGGAGGCCCCAGGCACCAGGAGGTATACCCTTGCAGAGAAGCGGGAAACAGTCATCCTAAAATGCA
ATGTCAAAGATTCCAGCATGTTGATCTCTCTTACCTACGATGTGATCCTGGTGATCTTATGCACTGTGTACGCCTTCAAAACGCGGAAGT
GCCCAGAAAATTTCAACGAAGCTAAGTTCATAGGTTTTACCATGTACACCACGTGCATCATCTGGTTGGCCTTCCTCCCTATATTTTATG
TGACATCAAGTGACTACAGAGTTGTCACACACAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCA
TCGAGGAGGTGCGTTGCAGCACCGCAGCTCACGCTTTCAAGGTGGCTGCCCGGGCCACGCTGCGCCGCAGCAACGTCTCCCGCAAGCGGT
CCAGCAGCCTTGGAGGCTCCACGGGATCCACCCCCTCCTCCTCCATCAGCAGCAAGAGCAACAGCGAAGACCCATTCCCACAGCCCGAGA
GGCAGAAGCAGCAGCAGCCGCTGGCCCTAACCCAGCAAGAGCAGCAGCAGCAGCCCCTGACCCTCCCACAGCAGCAACGATCTCAGCAGC
AGCCCAGATGCAAGCAGAAGGTCATCTTTGGCAGCGGCACGGTCACCTTCTCACTGAGCTTTGATGAGCCTCAGAAGAACGCCATGGCCC
ACAGGAATTCTACGCACCAGAACTCCCTGGAGGCCCAGAAAAGCAGCGATACGCTGACCCGACACGAGCCATTACTCCCGCTGCAGTGCG
GGGAAACGGACTTAGATCTGACCGTCCAGGAAACAGGTCTGCAAGGACCTGTGGGTGGAGACCAGCGGCCAGAGGTGGAGGACCCTGAAG
AGTTGTCCCCAGCACTTGTAGTGTCCAGTTCACAGAGCTTTGTCATCAGTGGTGGAGGCAGCACTGTTACAGAAAACGTAGTGAATTCAT
AAAATGGAAGGAGAAGACTGGGCTAGGGAGAATGCAGAGAGGTTTCTTGGGGTCCCAGGGAAGAGGAATCGCCCCAGACTCCTTTCCTCT
GAGGAAGAAGGGATAATAGACACATCAAATGCCCCGAATTTAGTCACACCATCTTAAATGACAGTGAATTGACCCATGTTCCCTTTAAAA
TTAAAAAAAAGAAGAGCCTTGTGTTTCTGTGGTTGCATTTGTCAAAGCATTGAGATCTCCACGGTCAGATTTGCTGTTCACCCACATCTA
ATGTCTCTTCCTCTGTTCTATCCCACCCAACAGCTCAGAGATGAAACTATGGCTTTAAACTACCCTCCAGAGTGTGCAGACTGATGGGAC
ATCAAATTTGCCACCACTAGAGCTGAGAGTCTGAAAGACAGAATGTCACCAGTCCTGCCCAATGCCTTGACAACAGACTGAATTTTAAAT
GTTCACAACATAAGGAGAATGTATCTCCTCCTATTTATGAAAACCATATGATATTTTGTCTCCTACCTGCTGCTGCTATTATGTAACATC
CAGAAGGTTTGCACCCCTCCTATACCATATGTCTGCTTCTGTCCAGGACATGATACTGATGCCATGTTTAGATTCCAGGATCACAAGAAT
CACCTCAAATTGTTAGGAAGGGACTGCATAAACCAATGAGCTGTATCTGTAATTAATATTCCTATATGTAGCTTTATCCTTAGGAAAATG
CTTCTGTTGTAATAGTCCATGGACAATATAAACTGAAAAATGTCAGTCTGGTTTATATAAGGCAGTATTATTGAGCTCTATTTCCCCACC
CCACTATCCTCACTCCCATAAGCTAAGCCTTATGTGAGCCCCTTCAGGGACTCAAGGGTCCAGAAGTCCCTCCCATCTCTACCCCAAAGA
ATTCCTGAAGCCAGATCCACCCTATCCCTGTACAGAGTAAGTTCTCAATTATTGGCCTGCTAATAGCTGCTAGGGTAGGAAAGCGTGGTT
CCAAGAAAGATCCACCCTCAAATGTCAGAGCTATGTTCCCTCCAGCAGTGGTATTAATACTGCCGGTCACCCAGGCTCTGGAGCCAGAGA
GACAGACCGGGGTTCAAGCCATGGCTTCGTCATTTGCAAGCTGAGTGACTGTAGGCAGGGAACCTTAACCTCTCTAAGCCACAGCTTCTT
CATCTTTAAAATAAGGATAATAATCATTCTTTCCCCTCAGAGCTCTTATGTGGATTAAACGAGATAATGTATATAAAGTACTTTAGCCTG

>34900_34900_3_GRM3-CASR_GRM3_chr7_86479793_ENST00000546348_CASR_chr3_122003403_ENST00000498619_length(amino acids)=625AA_BP=349
MCRMRRTNHEPEPGCRLTAAAATAVSSSSCQELSVRAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVN
SIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIAC
LGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKN
GAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENF
NEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVVTHRLHLNRFSVSGTGTTYSQSIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLG
GSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNST

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GRM3-CASR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406880_90001079.0RNF19A
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107880_90001079.0RNF19A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GRM3-CASR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GRM3-CASR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource