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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRTP1-COL4A2 (FusionGDB2 ID:34961)

Fusion Gene Summary for GRTP1-COL4A2

Fusion gene summary

Fusion gene information	Fusion gene name: GRTP1-COL4A2
	Fusion gene ID: 34961
		Hgene	Tgene
	Gene symbol	GRTP1	COL4A2
	Gene ID	79774	1284
	Gene name	growth hormone regulated TBC protein 1	collagen type IV alpha 2 chain
	Synonyms	TBC1D6	BSVD2\|ICH\|POREN2
	Cytomap	13q34	13q34
	Type of gene	protein-coding	protein-coding
	Description	growth hormone-regulated TBC protein 1TBC1 domain family member 6	collagen alpha-2(IV) chaincanstatin
	Modification date	20200313	20200313
	UniProtAcc	Q5TC63	P08572
	Ensembl transtripts involved in fusion gene	ENST00000326039, ENST00000375430, ENST00000375431, ENST00000476439,	ENST00000462309, ENST00000360467,
Fusion gene scores	* DoF score	8 X 10 X 5=400	9 X 10 X 5=450
	# samples	12	8
	** MAII score	log2(12/400*10)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/450*10)=-2.49185309632967 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRTP1 [Title/Abstract] AND COL4A2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRTP1(113999178)-COL4A2(111154015), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	COL4A2	GO:0016525	negative regulation of angiogenesis	10625665

Fusion gene breakpoints across GRTP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COL4A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-69-7979-01A	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+

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Fusion Gene ORF analysis for GRTP1-COL4A2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000326039	ENST00000462309	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
5CDS-intron	ENST00000375430	ENST00000462309	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
5CDS-intron	ENST00000375431	ENST00000462309	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
In-frame	ENST00000326039	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
In-frame	ENST00000375430	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
In-frame	ENST00000375431	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
intron-3CDS	ENST00000476439	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+
intron-intron	ENST00000476439	ENST00000462309	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375431	GRTP1	chr13	113999178	-	ENST00000360467	COL4A2	chr13	111154015	+	2852	637	42	2015	657
ENST00000326039	GRTP1	chr13	113999178	-	ENST00000360467	COL4A2	chr13	111154015	+	2551	336	8	1714	568
ENST00000375430	GRTP1	chr13	113999178	-	ENST00000360467	COL4A2	chr13	111154015	+	2824	609	14	1987	657

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375431	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+	0.00778658	0.9922134
ENST00000326039	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+	0.006187174	0.9938128
ENST00000375430	ENST00000360467	GRTP1	chr13	113999178	-	COL4A2	chr13	111154015	+	0.007714164	0.99228585

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Fusion Genomic Features for GRTP1-COL4A2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GRTP1	chr13	113999177	-	COL4A2	chr13	111154014	+	0.00336775	0.9966323
GRTP1	chr13	113999177	-	COL4A2	chr13	111154014	+	0.00336775	0.9966323

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRTP1-COL4A2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113999178/chr13:111154015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRTP1 Q5TC63	COL4A2 P08572
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s).	FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COL4A2

chr13:113999178

chr13:111154015

ENST00000360467

1489_1712

1253

1713.0

Domain

Collagen IV NC1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRTP1

chr13:113999178

chr13:111154015

ENST00000326039

68_258

109

267.0

Domain

Rab-GAP TBC

Hgene

GRTP1

chr13:113999178

chr13:111154015

ENST00000375431

68_258

187

337.0

Domain

Rab-GAP TBC

Tgene

COL4A2

chr13:113999178

chr13:111154015

ENST00000360467

184_1484

1253

1713.0

Region

Note=Triple-helical region

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Fusion Gene Sequence for GRTP1-COL4A2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34961_34961_1_GRTP1-COL4A2_GRTP1_chr13_113999178_ENST00000326039_COL4A2_chr13_111154015_ENST00000360467_length(transcript)=2551nt_BP=336nt
GCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACCCCA
GGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGAGGA
CCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGATTC
TTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGAGCC
CAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCCTGA
AAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAACCC
CAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTGAAC
AAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTGCCC
CCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAGGCC
CCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAGGAA
GAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAGGCC
GTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGGAGC
CCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACCTGG
GGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGAACG
ACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTTCTG
TGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGATCG
GATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCCGCG
CCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCGAGC
AGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGCCTCATCCGCACACACATCAGCCGCTGCCAGGTGTGCATGAAGAACC
TGTGAGCCGGCGCGTGCCAGGAAGGGCCATTTTGGTGCTTATTCTTAACTTATTACCTCAGGTGCCAACCCAAAAATTGGTTTTATTTTT
TTCTTAAAAAAAAAAAAGTCTACCAAAGGAATTTGCATCCAGCAGCAGCACTTAGACCTGCCAGCCACTGTCACCGAGCGGGTGCAAGCA
CTCGGGGTCCCTGGAGGGCAAGCCCTGCCCACAGAAAGCCAGGAGCAGCCCTGGCCCCCATCAGCCCTGCTAGACGCACCGCCTGAAGGC
ACAGCTAACCACTTCGCACACACCCATGTAACCACTGCACTTTCCAATGCCACAGACAACTCACATTGTTCAACTCCCTTCTCGGGGTGG
GACAGACGAGACAACAGCACACAGGCAGCCAGCCGTGGCCAGAGGCTCGAGGGGCTCAGGGCCTCAGGCACCCGTCCCCACACGAGGGCC
CCGTGGGTGGGCCTGGCCCTGCTTTCTACGCCAATGTTATGCCAGCTCCATGTTCTCCCAAATACCGTTGATGTGAATTATTTTAAAGGC
AAAACCGTGCTCTTTATTTTAAAAAACACTGATAATCACACTGCGGTAGGTCATTCTTTTGCCACATCCCTATAGACCACTGGGTTTGGC
AAAACTCAGGCAGAAGTGGAGACCTTTCTAGACATCATTGTCAGCCTTGCTACTTGAAGGTACACCCCATAGGGTCGGAGGTGCTGTCCC
CACTGCCCCACGTTGTCCCTGAGATTTAACCCCTCCACTGCTGGGGGTGAGCTGTACTCTTCTGACTGCCCCCTCCTGTGTAACGACTAC

>34961_34961_1_GRTP1-COL4A2_GRTP1_chr13_113999178_ENST00000326039_COL4A2_chr13_111154015_ENST00000360467_length(amino acids)=568AA_BP=0
MVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILIT
NNEEESFWLLDALVGRILPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGT
KGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPG
APGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMC
PVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCE
APAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSF

--------------------------------------------------------------
>34961_34961_2_GRTP1-COL4A2_GRTP1_chr13_113999178_ENST00000375430_COL4A2_chr13_111154015_ENST00000360467_length(transcript)=2824nt_BP=609nt
GAACTTGGGACCCGCTGGCCTCGCTCGGTGCGCGCCTCCCTCCCCGCATGCAGCCCGCCGAGCGCTCGCGGGTCCCCAGGATCGACCCGT
ACGGATTCGAGCGGCCTGAGGACTTCGACGACGCCGCCTACGAGAAGTTTTTCTCCAGCTACCTGGTCACGCTCACCCGCAGGGCGATCA
AATGGTCCCGGCTGCTGCAGGGCGGGGGCGTCCCCAGGAGCCGGACAGTGAAGCGCTATGTCCGGAAAGGGGTCCCGCTGGAGCACCGTG
CCCGCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACC
CCAGGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGA
GGACCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGA
TTCTTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGA
GCCCAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCC
TGAAAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAA
CCCCAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTG
AACAAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTG
CCCCCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAG
GCCCCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAG
GAAGAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAG
GCCGTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGG
AGCCCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACC
TGGGGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGA
ACGACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTT
CTGTGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGA
TCGGATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCC
GCGCCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCG
AGCAGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGCCTCATCCGCACACACATCAGCCGCTGCCAGGTGTGCATGAAGA
ACCTGTGAGCCGGCGCGTGCCAGGAAGGGCCATTTTGGTGCTTATTCTTAACTTATTACCTCAGGTGCCAACCCAAAAATTGGTTTTATT
TTTTTCTTAAAAAAAAAAAAGTCTACCAAAGGAATTTGCATCCAGCAGCAGCACTTAGACCTGCCAGCCACTGTCACCGAGCGGGTGCAA
GCACTCGGGGTCCCTGGAGGGCAAGCCCTGCCCACAGAAAGCCAGGAGCAGCCCTGGCCCCCATCAGCCCTGCTAGACGCACCGCCTGAA
GGCACAGCTAACCACTTCGCACACACCCATGTAACCACTGCACTTTCCAATGCCACAGACAACTCACATTGTTCAACTCCCTTCTCGGGG
TGGGACAGACGAGACAACAGCACACAGGCAGCCAGCCGTGGCCAGAGGCTCGAGGGGCTCAGGGCCTCAGGCACCCGTCCCCACACGAGG
GCCCCGTGGGTGGGCCTGGCCCTGCTTTCTACGCCAATGTTATGCCAGCTCCATGTTCTCCCAAATACCGTTGATGTGAATTATTTTAAA
GGCAAAACCGTGCTCTTTATTTTAAAAAACACTGATAATCACACTGCGGTAGGTCATTCTTTTGCCACATCCCTATAGACCACTGGGTTT
GGCAAAACTCAGGCAGAAGTGGAGACCTTTCTAGACATCATTGTCAGCCTTGCTACTTGAAGGTACACCCCATAGGGTCGGAGGTGCTGT
CCCCACTGCCCCACGTTGTCCCTGAGATTTAACCCCTCCACTGCTGGGGGTGAGCTGTACTCTTCTGACTGCCCCCTCCTGTGTAACGAC

>34961_34961_2_GRTP1-COL4A2_GRTP1_chr13_113999178_ENST00000375430_COL4A2_chr13_111154015_ENST00000360467_length(amino acids)=657AA_BP=1
MASLGARLPPRMQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWM
VLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITN
NEEESFWLLDALVGRILPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTK
GWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGA
PGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCP
VGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEA
PAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQ

--------------------------------------------------------------
>34961_34961_3_GRTP1-COL4A2_GRTP1_chr13_113999178_ENST00000375431_COL4A2_chr13_111154015_ENST00000360467_length(transcript)=2852nt_BP=637nt
GGACTTAAGCGCCCCGGAGCCGGGAGGCGAACTTGGGACCCGCTGGCCTCGCTCGGTGCGCGCCTCCCTCCCCGCATGCAGCCCGCCGAG
CGCTCGCGGGTCCCCAGGATCGACCCGTACGGATTCGAGCGGCCTGAGGACTTCGACGACGCCGCCTACGAGAAGTTTTTCTCCAGCTAC
CTGGTCACGCTCACCCGCAGGGCGATCAAATGGTCCCGGCTGCTGCAGGGCGGGGGCGTCCCCAGGAGCCGGACAGTGAAGCGCTATGTC
CGGAAAGGGGTCCCGCTGGAGCACCGTGCCCGCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTAC
CACCAGCTTCTCCAGGGAGAGAGAAACCCCAGGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTC
CGGAAGACCACGGACCCCTGCTTACAGAGGACCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAG
GGAATGAATTTTATAGCAGGATATCTGATTCTTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATA
CTACCAGGGGAACGAGGCCCACCTGGGAGCCCAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGT
GACAAAGGGGCGCCAGGGATATTTGGCCTGAAAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGT
GACACAGGGAACCCAGGAGCTCCAGGAACCCCAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGT
CTCCCAGGAGAAAAAGGGCCCAGGGGTGAACAAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGA
CCCAAGGGAGACCCAGGATTCCCTGGTGCCCCCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCA
GGGACAGTGGGTCCCCAGGGGAGGCGAGGCCCCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGT
GGGGCTCCAGGGAAAGCTGGGCCCCAAGGAAGAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAG
GGGCCGATTGGCCAAGAAGGTGCACCAGGCCGTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTC
CTGGTGAAGCACAGCCAGACGGACCAGGAGCCCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAG
GGCCAGGAGAAGGCGCACAACCAGGACCTGGGGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCT
GGTGATGTCTGCTACTATGCCAGCCGGAACGACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGAC
GAGATCAAGCCCTACATCAGCCGCTGTTCTGTGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACAC
TGCCCAGCTGGGTGGCGGAGTTTGTGGATCGGATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTG
TCACCGGGCAGCTGTCTAGAGGACTTCCGCGCCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAG
TACAGCTTCTGGCTGACCACCATTCCCGAGCAGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGCCTCATCCGCACACAC
ATCAGCCGCTGCCAGGTGTGCATGAAGAACCTGTGAGCCGGCGCGTGCCAGGAAGGGCCATTTTGGTGCTTATTCTTAACTTATTACCTC
AGGTGCCAACCCAAAAATTGGTTTTATTTTTTTCTTAAAAAAAAAAAAGTCTACCAAAGGAATTTGCATCCAGCAGCAGCACTTAGACCT
GCCAGCCACTGTCACCGAGCGGGTGCAAGCACTCGGGGTCCCTGGAGGGCAAGCCCTGCCCACAGAAAGCCAGGAGCAGCCCTGGCCCCC
ATCAGCCCTGCTAGACGCACCGCCTGAAGGCACAGCTAACCACTTCGCACACACCCATGTAACCACTGCACTTTCCAATGCCACAGACAA
CTCACATTGTTCAACTCCCTTCTCGGGGTGGGACAGACGAGACAACAGCACACAGGCAGCCAGCCGTGGCCAGAGGCTCGAGGGGCTCAG
GGCCTCAGGCACCCGTCCCCACACGAGGGCCCCGTGGGTGGGCCTGGCCCTGCTTTCTACGCCAATGTTATGCCAGCTCCATGTTCTCCC
AAATACCGTTGATGTGAATTATTTTAAAGGCAAAACCGTGCTCTTTATTTTAAAAAACACTGATAATCACACTGCGGTAGGTCATTCTTT
TGCCACATCCCTATAGACCACTGGGTTTGGCAAAACTCAGGCAGAAGTGGAGACCTTTCTAGACATCATTGTCAGCCTTGCTACTTGAAG
GTACACCCCATAGGGTCGGAGGTGCTGTCCCCACTGCCCCACGTTGTCCCTGAGATTTAACCCCTCCACTGCTGGGGGTGAGCTGTACTC

>34961_34961_3_GRTP1-COL4A2_GRTP1_chr13_113999178_ENST00000375431_COL4A2_chr13_111154015_ENST00000360467_length(amino acids)=657AA_BP=1
MASLGARLPPRMQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWM
VLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITN
NEEESFWLLDALVGRILPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTK
GWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGA
PGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCP
VGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEA
PAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQ

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Fusion Gene PPI Analysis for GRTP1-COL4A2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GRTP1-COL4A2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRTP1-COL4A2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source