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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKT3-DESI2 (FusionGDB2 ID:3498)

Fusion Gene Summary for AKT3-DESI2

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT3-DESI2
Fusion gene ID: 3498
HgeneTgene
Gene symbol

AKT3

DESI2

Gene ID

10000

51029

Gene nameAKT serine/threonine kinase 3desumoylating isopeptidase 2
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2C1orf121|CGI-146|DESI|DESI1|DeSI-2|FAM152A|PNAS-4|PPPDE1
Cytomap

1q43-q44

1q44

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)deubiquitinase DESI2PPPDE peptidase domain-containing protein 1desumoylating isopeptidase 1family with sequence similarity 152, member A
Modification date2020031320200313
UniProtAcc

Q9Y243

Q9BSY9

Ensembl transtripts involved in fusion geneENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
ENST00000492957, 		ENST00000484738, 
ENST00000263831, ENST00000302550, 
Fusion gene scores* DoF score18 X 15 X 7=18901 X 1 X 1=1
# samples 211
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: AKT3 [Title/Abstract] AND DESI2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT3(244006427)-DESI2(244849899), # samples:1
Anticipated loss of major functional domain due to fusion event.AKT3-DESI2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-DESI2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-DESI2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT3-DESI2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DESI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4343-01AAKT3chr1

244006427

-DESI2chr1

244849899

+


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Fusion Gene ORF analysis for AKT3-DESI2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263826ENST00000484738AKT3chr1

244006427

-DESI2chr1

244849899

+
5CDS-intronENST00000336199ENST00000484738AKT3chr1

244006427

-DESI2chr1

244849899

+
5CDS-intronENST00000366539ENST00000484738AKT3chr1

244006427

-DESI2chr1

244849899

+
5CDS-intronENST00000366540ENST00000484738AKT3chr1

244006427

-DESI2chr1

244849899

+
Frame-shiftENST00000366540ENST00000263831AKT3chr1

244006427

-DESI2chr1

244849899

+
Frame-shiftENST00000366540ENST00000302550AKT3chr1

244006427

-DESI2chr1

244849899

+
In-frameENST00000263826ENST00000263831AKT3chr1

244006427

-DESI2chr1

244849899

+
In-frameENST00000263826ENST00000302550AKT3chr1

244006427

-DESI2chr1

244849899

+
In-frameENST00000336199ENST00000263831AKT3chr1

244006427

-DESI2chr1

244849899

+
In-frameENST00000336199ENST00000302550AKT3chr1

244006427

-DESI2chr1

244849899

+
In-frameENST00000366539ENST00000263831AKT3chr1

244006427

-DESI2chr1

244849899

+
In-frameENST00000366539ENST00000302550AKT3chr1

244006427

-DESI2chr1

244849899

+
intron-3CDSENST00000492957ENST00000263831AKT3chr1

244006427

-DESI2chr1

244849899

+
intron-3CDSENST00000492957ENST00000302550AKT3chr1

244006427

-DESI2chr1

244849899

+
intron-intronENST00000492957ENST00000484738AKT3chr1

244006427

-DESI2chr1

244849899

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1244006427-ENST00000302550DESI2chr1244849899+3899112118654178
ENST00000336199AKT3chr1244006427-ENST00000263831DESI2chr1244849899+718112118555145
ENST00000366539AKT3chr1244006427-ENST00000302550DESI2chr1244849899+4034247253789178
ENST00000366539AKT3chr1244006427-ENST00000263831DESI2chr1244849899+853247253690145
ENST00000263826AKT3chr1244006427-ENST00000302550DESI2chr1244849899+3914127133669178
ENST00000263826AKT3chr1244006427-ENST00000263831DESI2chr1244849899+733127133570145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000302550AKT3chr1244006427-DESI2chr1244849899+0.0013606610.9986393
ENST00000336199ENST00000263831AKT3chr1244006427-DESI2chr1244849899+0.0075894170.99241054
ENST00000366539ENST00000302550AKT3chr1244006427-DESI2chr1244849899+0.0014072250.9985928
ENST00000366539ENST00000263831AKT3chr1244006427-DESI2chr1244849899+0.0030734030.9969266
ENST00000263826ENST00000302550AKT3chr1244006427-DESI2chr1244849899+0.0014003850.9985996
ENST00000263826ENST00000263831AKT3chr1244006427-DESI2chr1244849899+0.0078674110.9921326

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Fusion Genomic Features for AKT3-DESI2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AKT3chr1244006426-DESI2chr1244849898+4.29E-050.9999571
AKT3chr1244006426-DESI2chr1244849898+4.29E-050.9999571

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AKT3-DESI2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:244006427/chr1:244849899)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT3

Q9Y243

DESI2

Q9BSY9

FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.FUNCTION: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). {ECO:0000269|PubMed:28483520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:244006427chr1:244849899ENST00000263826-113148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244849899ENST00000263826-113406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244849899ENST00000263826-1135_10715480.0DomainPH
HgeneAKT3chr1:244006427chr1:244849899ENST00000336199-114148_40515476.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244849899ENST00000336199-114406_47915476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244849899ENST00000336199-1145_10715476.0DomainPH
HgeneAKT3chr1:244006427chr1:244849899ENST00000366539-214148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244849899ENST00000366539-214406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244849899ENST00000366539-2145_10715480.0DomainPH
HgeneAKT3chr1:244006427chr1:244849899ENST00000366540-214148_40515466.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244849899ENST00000366540-214406_47915466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244849899ENST00000366540-2145_10715466.0DomainPH
HgeneAKT3chr1:244006427chr1:244849899ENST00000263826-113154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244849899ENST00000336199-114154_16215476.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244849899ENST00000366539-214154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244849899ENST00000366540-214154_16215466.0Nucleotide bindingATP
TgeneDESI2chr1:244006427chr1:244849899ENST00000263831045_14914162.0DomainPPPDE
TgeneDESI2chr1:244006427chr1:244849899ENST00000302550055_14914195.0DomainPPPDE


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Fusion Gene Sequence for AKT3-DESI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3498_3498_1_AKT3-DESI2_AKT3_chr1_244006427_ENST00000263826_DESI2_chr1_244849899_ENST00000263831_length(transcript)=733nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGTATTGGATGAACGAATATACCTCATCCATTGGAATTGGAGTTTTTCATTCAGG
AATTGAAGTCTATGGCAGAGCTGTTGTTTTAGGGAGCACGGACTTCCTAGAAGATGATATAGAAAAAATTGTAGAAGAACTGGGAAAAGA
ATACAAAGGCAATGCTTATCATTTAATGCATAAAAACTGCAATCATTTTTCTTCAGCTTTATCAGAGATTCTTTGTGGGAAAGAGATTCC
TCGCTGGATCAATCGACTTGCCTACTTCAGCTCCTGTATACCCTTTCTACAGAGTTGCCTCCCGAAGGAGTGGCTCACGCCCGCAGCCCT
GCAGTCTAGTGTCAGCCAAGAACTCCAGGATGAACTGGAGGAAGCAGAGGATGCTGCCGCATCCGCTTCCGTGGCAAGCACTGCAGCAGG
CTCCAGACCCGGGCGCCACACTAAACTATAAATGTCTCCAAAGTCACACATTCAGAACTGTCTCTGGCAGTCGAATATCACTAGAGAAAA
GTAAACAGAGAAGCATCCTTTAGATATTTTGTATGCAAAGATGGCTCTCCCCCAAATCCCAGTTTTTCAGCTCAGGATTATATTTGTAAT

>3498_3498_1_AKT3-DESI2_AKT3_chr1_244006427_ENST00000263826_DESI2_chr1_244849899_ENST00000263831_length(amino acids)=145AA_BP=0
MNEYTSSIGIGVFHSGIEVYGRAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIP

--------------------------------------------------------------
>3498_3498_2_AKT3-DESI2_AKT3_chr1_244006427_ENST00000263826_DESI2_chr1_244849899_ENST00000302550_length(transcript)=3914nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGTATTGGATGAACGAATATACCTCATCCATTGGAATTGGAGTTTTTCATTCAGG
AATTGAAGTCTATGGCAGAGAATTTGCTTATGGTGGCCATCCTTACCCCTTTTCTGGAATATTTGAAATTTCCCCAGGAAATGCTTCTGA
ACTAGGAGAAACATTTAAATTTAAAGAAGCTGTTGTTTTAGGGAGCACGGACTTCCTAGAAGATGATATAGAAAAAATTGTAGAAGAACT
GGGAAAAGAATACAAAGGCAATGCTTATCATTTAATGCATAAAAACTGCAATCATTTTTCTTCAGCTTTATCAGAGATTCTTTGTGGGAA
AGAGATTCCTCGCTGGATCAATCGACTTGCCTACTTCAGCTCCTGTATACCCTTTCTACAGAGTTGCCTCCCGAAGGAGTGGCTCACGCC
CGCAGCCCTGCAGTCTAGTGTCAGCCAAGAACTCCAGGATGAACTGGAGGAAGCAGAGGATGCTGCCGCATCCGCTTCCGTGGCAAGCAC
TGCAGCAGGCTCCAGACCCGGGCGCCACACTAAACTATAAATGTCTCCAAAGTCACACATTCAGAACTGTCTCTGGCAGTCGAATATCAC
TAGAGAAAAGTAAACAGAGAAGCATCCTTTAGATATTTTGTATGCAAAGATGGCTCTCCCCCAAATCCCAGTTTTTCAGCTCAGGATTAT
ATTTGTAATCAAAAAAAAAAAATCACTTGGCGCAGGAGGGAGAACTTTGTAAGAAGCTGCCCTCTGTTTTTTTTATCCACTCGTAAATCT
GGATTTATTTCTTCTGTTTTATACAAGCTCTGTTAAGTTATGTTTACAGTATCTTGTATCGCTGTTTACAAATCTTGCATGGACTCCTGC
CACAGTGAAAGAAGAAAATCTTCATGTCTTCAAAAATTAGGCAGGTAATCTTTGTATACTTCTGACAATTGCCAGATCTATGGCATAAAT
AGGCACACAAAAAGGTACTTAAACAGTTATAGTCACCATCACCTGCTTCAGAATGGTCTTTTAGATTTGTGTTTGTTTTGTTAAAGTTGT
TGGCACCAGGATGCAGAGAATCAGACTGGCCTGAGGTGAAGGAGCACACAGCCCTGAGGGCTTGGAACCCTGGGTCCAGTTCCTCTTCAC
ACCCCCTTCCACTCTGAGTAGCACATCTCCCCAGGTGCCCATGGAACACCTGCTTTCATCCCAAATATCCGTCCACCTAGGCGGGGTGGT
ATGTTCTTACGTCTCTCTGACTTTGATGCCACTCATTCTATAGTTTAGCTGGTTTTCGTTCAAGATATTCTTGGTAGTAACTGACAAGTA
TGTTGCACATGTATTGGGGGAGGCGCTTCATTTTTATTTTAATACACATGTATTTCCTCCTTGCACAGGATTTTGATGGTGTGGGAATAT
CCTAAGTGGTAGCCTTCCAAGTAGCAGTGAGTTGACATTCAGCTGCTTTTAACTATTCAGGCTACCTTTTATACTAAACCTTGAAAACTA
GAATCTAATGTCTACCCCAAAAAAGTAGTTCTTTGATATTTTATACTTTTTATGTACCATGTCAGAAAGAGTATGTTGGCGTTTGTCATG
GGACTCATTTCACATAATAGAATGCCTAGTCTCATTGACCAATCGTTAAAAAATCATATTTGTGTGTCTTAAGATTCATATTTATATGTT
CTCTCAAATGTATGTCTCTTACGTAACATACTCTAAGAATGAAACTGTCACCACAGGTAAATCCTTGTTAGCAAGGAATCTGTCTGCTCC
AGTCTACTCCTAGTTTGATCCTTGGATGTAAGAACCAAGTCATTACATGTCAAATTCAATTTTTCTGCCTTAAGAATGAATGTCCTTCAT
AAAATATTGGATGCAGTGTAACACTATCCAAGGCAGTGACTTCAGCTTTATATACATATAAAATATAGTTAGTTTTAAAATTATTGACAT
TTATTTAAACTTTTAGATTGGATTGTTTGCTATTGCTCTGTGTGAGGATACATAATCTTTCAGTAAACTGTATTTTTAACTTTTCCATAA
GCTGATTTTGGTTCATTTTATCAACGTAAGCACACCCTGTTCATAGGGAAAATAAACCTTGGGTTATAAGCATTAGCCTGAGGACAATGA
AGCCACTTAACCTAATTTATGCTTTCGACTGTTCTGTTTCCAGAGAGGAAAGCCTTTACAAATTACTCTCAGTTCTTTAGGGGCAGAAGG
CTTGTTTCAAGAGGTTTGACAGAAGAAAGGAATATATGAACTTAATGAGATGTCGACTTGGTTCAGGTCTAAAAATGAGGGCAAAACACT
AAGGCTCTAGCAGTGACTTGTTCACTAAAAAGAGAGAGTCCTGTCCCCAGACGGTTAGTACAAAGCCTTGGATACAGTTTGCTTGTAATA
TTTTTAATAATGTGAGGAGTACAGTGTTTTCTAATTCATTCAAGTATATATGATTTAAACCTGGGCTACTGACACACACACAGTAGCCAT
TAGTTAGACTCTTCTTAGTGAATATCAGGAACATCCCATCTGTGCTTAACCAGAATCCAGCAAGTCAGCACACAAGTGATTTTATTGTTA
TTTTGTTGTATTTACTTGCATTTGTTGTATTTACTTTCATCTGCAGCATTTGGAGTTTAAAAATAATGTAAAGGGTTCTAGTAGAAATAG
TGTCCTAAGGCCAATTACCTACCATACTAACAATCAGCAGATAAAATTCTGGACGTGAGATTCCTTATAATCTAATTATACCTGAGGTTG
AGCAAGAAATGTCTTCCTTTAGAAAATCTCATTCAAGTCAGGTTCTTCTCTACAGTTCAAAATTGAGAATGGATTTAATTAACTAGCATT
TAGCCAGCTTTTTCTTGCCCTTGGAGAAAAAGAATCATTCTCAACCTGATAATCTGTTAAGAAAAATCCCATATGAACAATCTGGTCATT
AACATACATATGATACGGAGTCTCTTTGTTGTCACCAAGTGAACATACTTCTCATGGTGGGTTGGACAGTAATACATGTTAGAGGGTCAG
AAGCTTCTGGTTTCTGCTGTTTGCTTTAAATACCCTTGGGGTTTTTTTTTAAACCCTTACAAGGGGAGCATCAGCTTTGGAAAGTGTGAC
TCTGTAGGAGTGTAGAAGGCAGTGGTGTATGATCTTAGCCTCGTCCTGATGCCTGAATCCAGCCAGCTGTTGCTCTGACCCACAGCAATA
GAGCAAGTTACCCATCACCAGCATTTGTACAGAGCAGGGAATTCTGGTTTTAGTCCATTGGTAGCATTGTGTGTATGAGGAGATTCAACA
CCACAGACAGCTGCAGGACTCGATATCCATGGCTTCTTTCCATCACAAAACGGGTAGAAACACATTCACTGCTTCAGGGTTCTAATCTGT
GTGTCTCCTTATGACTCCATTTCTGTAAGCTACTCTGTAACTTTGATATATGCTGTATTTTCTTTCTTTAAAAGATTTAGATGTTTTTTC
AGCAAGCTAGCCATACAACCATTGTATCTCTTTCTCTTCAGTATGGTTTAGAGCCCAGATCAGTTAGTAGGCTTTCGTTGTCTTCTCTTT
CAATACATGTACATCTTTACTGTTTGAAAAGTGTTACAGCTGTCAAAGAATCTTCATGGACCTGAAGATAATTTCTTGTGAAGTTGAATG
CAAGTGTACTGTCATTCATAGTGTTTATATCAAAATACCAGGAATCTTCACTTTTGCTACCTTGATATAGCATTGGGCTATCATGTTACA

>3498_3498_2_AKT3-DESI2_AKT3_chr1_244006427_ENST00000263826_DESI2_chr1_244849899_ENST00000302550_length(amino acids)=178AA_BP=0
MNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHK

--------------------------------------------------------------
>3498_3498_3_AKT3-DESI2_AKT3_chr1_244006427_ENST00000336199_DESI2_chr1_244849899_ENST00000263831_length(transcript)=718nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGTATTGGATGAACGAATATACCTCATCCATTGGAATTGGAGTTTTTCATTCAGGAATTGAAGTCTATGG
CAGAGCTGTTGTTTTAGGGAGCACGGACTTCCTAGAAGATGATATAGAAAAAATTGTAGAAGAACTGGGAAAAGAATACAAAGGCAATGC
TTATCATTTAATGCATAAAAACTGCAATCATTTTTCTTCAGCTTTATCAGAGATTCTTTGTGGGAAAGAGATTCCTCGCTGGATCAATCG
ACTTGCCTACTTCAGCTCCTGTATACCCTTTCTACAGAGTTGCCTCCCGAAGGAGTGGCTCACGCCCGCAGCCCTGCAGTCTAGTGTCAG
CCAAGAACTCCAGGATGAACTGGAGGAAGCAGAGGATGCTGCCGCATCCGCTTCCGTGGCAAGCACTGCAGCAGGCTCCAGACCCGGGCG
CCACACTAAACTATAAATGTCTCCAAAGTCACACATTCAGAACTGTCTCTGGCAGTCGAATATCACTAGAGAAAAGTAAACAGAGAAGCA

>3498_3498_3_AKT3-DESI2_AKT3_chr1_244006427_ENST00000336199_DESI2_chr1_244849899_ENST00000263831_length(amino acids)=145AA_BP=0
MNEYTSSIGIGVFHSGIEVYGRAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIP

--------------------------------------------------------------
>3498_3498_4_AKT3-DESI2_AKT3_chr1_244006427_ENST00000336199_DESI2_chr1_244849899_ENST00000302550_length(transcript)=3899nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGTATTGGATGAACGAATATACCTCATCCATTGGAATTGGAGTTTTTCATTCAGGAATTGAAGTCTATGG
CAGAGAATTTGCTTATGGTGGCCATCCTTACCCCTTTTCTGGAATATTTGAAATTTCCCCAGGAAATGCTTCTGAACTAGGAGAAACATT
TAAATTTAAAGAAGCTGTTGTTTTAGGGAGCACGGACTTCCTAGAAGATGATATAGAAAAAATTGTAGAAGAACTGGGAAAAGAATACAA
AGGCAATGCTTATCATTTAATGCATAAAAACTGCAATCATTTTTCTTCAGCTTTATCAGAGATTCTTTGTGGGAAAGAGATTCCTCGCTG
GATCAATCGACTTGCCTACTTCAGCTCCTGTATACCCTTTCTACAGAGTTGCCTCCCGAAGGAGTGGCTCACGCCCGCAGCCCTGCAGTC
TAGTGTCAGCCAAGAACTCCAGGATGAACTGGAGGAAGCAGAGGATGCTGCCGCATCCGCTTCCGTGGCAAGCACTGCAGCAGGCTCCAG
ACCCGGGCGCCACACTAAACTATAAATGTCTCCAAAGTCACACATTCAGAACTGTCTCTGGCAGTCGAATATCACTAGAGAAAAGTAAAC
AGAGAAGCATCCTTTAGATATTTTGTATGCAAAGATGGCTCTCCCCCAAATCCCAGTTTTTCAGCTCAGGATTATATTTGTAATCAAAAA
AAAAAAATCACTTGGCGCAGGAGGGAGAACTTTGTAAGAAGCTGCCCTCTGTTTTTTTTATCCACTCGTAAATCTGGATTTATTTCTTCT
GTTTTATACAAGCTCTGTTAAGTTATGTTTACAGTATCTTGTATCGCTGTTTACAAATCTTGCATGGACTCCTGCCACAGTGAAAGAAGA
AAATCTTCATGTCTTCAAAAATTAGGCAGGTAATCTTTGTATACTTCTGACAATTGCCAGATCTATGGCATAAATAGGCACACAAAAAGG
TACTTAAACAGTTATAGTCACCATCACCTGCTTCAGAATGGTCTTTTAGATTTGTGTTTGTTTTGTTAAAGTTGTTGGCACCAGGATGCA
GAGAATCAGACTGGCCTGAGGTGAAGGAGCACACAGCCCTGAGGGCTTGGAACCCTGGGTCCAGTTCCTCTTCACACCCCCTTCCACTCT
GAGTAGCACATCTCCCCAGGTGCCCATGGAACACCTGCTTTCATCCCAAATATCCGTCCACCTAGGCGGGGTGGTATGTTCTTACGTCTC
TCTGACTTTGATGCCACTCATTCTATAGTTTAGCTGGTTTTCGTTCAAGATATTCTTGGTAGTAACTGACAAGTATGTTGCACATGTATT
GGGGGAGGCGCTTCATTTTTATTTTAATACACATGTATTTCCTCCTTGCACAGGATTTTGATGGTGTGGGAATATCCTAAGTGGTAGCCT
TCCAAGTAGCAGTGAGTTGACATTCAGCTGCTTTTAACTATTCAGGCTACCTTTTATACTAAACCTTGAAAACTAGAATCTAATGTCTAC
CCCAAAAAAGTAGTTCTTTGATATTTTATACTTTTTATGTACCATGTCAGAAAGAGTATGTTGGCGTTTGTCATGGGACTCATTTCACAT
AATAGAATGCCTAGTCTCATTGACCAATCGTTAAAAAATCATATTTGTGTGTCTTAAGATTCATATTTATATGTTCTCTCAAATGTATGT
CTCTTACGTAACATACTCTAAGAATGAAACTGTCACCACAGGTAAATCCTTGTTAGCAAGGAATCTGTCTGCTCCAGTCTACTCCTAGTT
TGATCCTTGGATGTAAGAACCAAGTCATTACATGTCAAATTCAATTTTTCTGCCTTAAGAATGAATGTCCTTCATAAAATATTGGATGCA
GTGTAACACTATCCAAGGCAGTGACTTCAGCTTTATATACATATAAAATATAGTTAGTTTTAAAATTATTGACATTTATTTAAACTTTTA
GATTGGATTGTTTGCTATTGCTCTGTGTGAGGATACATAATCTTTCAGTAAACTGTATTTTTAACTTTTCCATAAGCTGATTTTGGTTCA
TTTTATCAACGTAAGCACACCCTGTTCATAGGGAAAATAAACCTTGGGTTATAAGCATTAGCCTGAGGACAATGAAGCCACTTAACCTAA
TTTATGCTTTCGACTGTTCTGTTTCCAGAGAGGAAAGCCTTTACAAATTACTCTCAGTTCTTTAGGGGCAGAAGGCTTGTTTCAAGAGGT
TTGACAGAAGAAAGGAATATATGAACTTAATGAGATGTCGACTTGGTTCAGGTCTAAAAATGAGGGCAAAACACTAAGGCTCTAGCAGTG
ACTTGTTCACTAAAAAGAGAGAGTCCTGTCCCCAGACGGTTAGTACAAAGCCTTGGATACAGTTTGCTTGTAATATTTTTAATAATGTGA
GGAGTACAGTGTTTTCTAATTCATTCAAGTATATATGATTTAAACCTGGGCTACTGACACACACACAGTAGCCATTAGTTAGACTCTTCT
TAGTGAATATCAGGAACATCCCATCTGTGCTTAACCAGAATCCAGCAAGTCAGCACACAAGTGATTTTATTGTTATTTTGTTGTATTTAC
TTGCATTTGTTGTATTTACTTTCATCTGCAGCATTTGGAGTTTAAAAATAATGTAAAGGGTTCTAGTAGAAATAGTGTCCTAAGGCCAAT
TACCTACCATACTAACAATCAGCAGATAAAATTCTGGACGTGAGATTCCTTATAATCTAATTATACCTGAGGTTGAGCAAGAAATGTCTT
CCTTTAGAAAATCTCATTCAAGTCAGGTTCTTCTCTACAGTTCAAAATTGAGAATGGATTTAATTAACTAGCATTTAGCCAGCTTTTTCT
TGCCCTTGGAGAAAAAGAATCATTCTCAACCTGATAATCTGTTAAGAAAAATCCCATATGAACAATCTGGTCATTAACATACATATGATA
CGGAGTCTCTTTGTTGTCACCAAGTGAACATACTTCTCATGGTGGGTTGGACAGTAATACATGTTAGAGGGTCAGAAGCTTCTGGTTTCT
GCTGTTTGCTTTAAATACCCTTGGGGTTTTTTTTTAAACCCTTACAAGGGGAGCATCAGCTTTGGAAAGTGTGACTCTGTAGGAGTGTAG
AAGGCAGTGGTGTATGATCTTAGCCTCGTCCTGATGCCTGAATCCAGCCAGCTGTTGCTCTGACCCACAGCAATAGAGCAAGTTACCCAT
CACCAGCATTTGTACAGAGCAGGGAATTCTGGTTTTAGTCCATTGGTAGCATTGTGTGTATGAGGAGATTCAACACCACAGACAGCTGCA
GGACTCGATATCCATGGCTTCTTTCCATCACAAAACGGGTAGAAACACATTCACTGCTTCAGGGTTCTAATCTGTGTGTCTCCTTATGAC
TCCATTTCTGTAAGCTACTCTGTAACTTTGATATATGCTGTATTTTCTTTCTTTAAAAGATTTAGATGTTTTTTCAGCAAGCTAGCCATA
CAACCATTGTATCTCTTTCTCTTCAGTATGGTTTAGAGCCCAGATCAGTTAGTAGGCTTTCGTTGTCTTCTCTTTCAATACATGTACATC
TTTACTGTTTGAAAAGTGTTACAGCTGTCAAAGAATCTTCATGGACCTGAAGATAATTTCTTGTGAAGTTGAATGCAAGTGTACTGTCAT
TCATAGTGTTTATATCAAAATACCAGGAATCTTCACTTTTGCTACCTTGATATAGCATTGGGCTATCATGTTACAACATTGAAATACATT

>3498_3498_4_AKT3-DESI2_AKT3_chr1_244006427_ENST00000336199_DESI2_chr1_244849899_ENST00000302550_length(amino acids)=178AA_BP=0
MNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHK

--------------------------------------------------------------
>3498_3498_5_AKT3-DESI2_AKT3_chr1_244006427_ENST00000366539_DESI2_chr1_244849899_ENST00000263831_length(transcript)=853nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGTATTGGATGAACGAATATACCTC
ATCCATTGGAATTGGAGTTTTTCATTCAGGAATTGAAGTCTATGGCAGAGCTGTTGTTTTAGGGAGCACGGACTTCCTAGAAGATGATAT
AGAAAAAATTGTAGAAGAACTGGGAAAAGAATACAAAGGCAATGCTTATCATTTAATGCATAAAAACTGCAATCATTTTTCTTCAGCTTT
ATCAGAGATTCTTTGTGGGAAAGAGATTCCTCGCTGGATCAATCGACTTGCCTACTTCAGCTCCTGTATACCCTTTCTACAGAGTTGCCT
CCCGAAGGAGTGGCTCACGCCCGCAGCCCTGCAGTCTAGTGTCAGCCAAGAACTCCAGGATGAACTGGAGGAAGCAGAGGATGCTGCCGC
ATCCGCTTCCGTGGCAAGCACTGCAGCAGGCTCCAGACCCGGGCGCCACACTAAACTATAAATGTCTCCAAAGTCACACATTCAGAACTG
TCTCTGGCAGTCGAATATCACTAGAGAAAAGTAAACAGAGAAGCATCCTTTAGATATTTTGTATGCAAAGATGGCTCTCCCCCAAATCCC

>3498_3498_5_AKT3-DESI2_AKT3_chr1_244006427_ENST00000366539_DESI2_chr1_244849899_ENST00000263831_length(amino acids)=145AA_BP=0
MNEYTSSIGIGVFHSGIEVYGRAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIP

--------------------------------------------------------------
>3498_3498_6_AKT3-DESI2_AKT3_chr1_244006427_ENST00000366539_DESI2_chr1_244849899_ENST00000302550_length(transcript)=4034nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGTATTGGATGAACGAATATACCTC
ATCCATTGGAATTGGAGTTTTTCATTCAGGAATTGAAGTCTATGGCAGAGAATTTGCTTATGGTGGCCATCCTTACCCCTTTTCTGGAAT
ATTTGAAATTTCCCCAGGAAATGCTTCTGAACTAGGAGAAACATTTAAATTTAAAGAAGCTGTTGTTTTAGGGAGCACGGACTTCCTAGA
AGATGATATAGAAAAAATTGTAGAAGAACTGGGAAAAGAATACAAAGGCAATGCTTATCATTTAATGCATAAAAACTGCAATCATTTTTC
TTCAGCTTTATCAGAGATTCTTTGTGGGAAAGAGATTCCTCGCTGGATCAATCGACTTGCCTACTTCAGCTCCTGTATACCCTTTCTACA
GAGTTGCCTCCCGAAGGAGTGGCTCACGCCCGCAGCCCTGCAGTCTAGTGTCAGCCAAGAACTCCAGGATGAACTGGAGGAAGCAGAGGA
TGCTGCCGCATCCGCTTCCGTGGCAAGCACTGCAGCAGGCTCCAGACCCGGGCGCCACACTAAACTATAAATGTCTCCAAAGTCACACAT
TCAGAACTGTCTCTGGCAGTCGAATATCACTAGAGAAAAGTAAACAGAGAAGCATCCTTTAGATATTTTGTATGCAAAGATGGCTCTCCC
CCAAATCCCAGTTTTTCAGCTCAGGATTATATTTGTAATCAAAAAAAAAAAATCACTTGGCGCAGGAGGGAGAACTTTGTAAGAAGCTGC
CCTCTGTTTTTTTTATCCACTCGTAAATCTGGATTTATTTCTTCTGTTTTATACAAGCTCTGTTAAGTTATGTTTACAGTATCTTGTATC
GCTGTTTACAAATCTTGCATGGACTCCTGCCACAGTGAAAGAAGAAAATCTTCATGTCTTCAAAAATTAGGCAGGTAATCTTTGTATACT
TCTGACAATTGCCAGATCTATGGCATAAATAGGCACACAAAAAGGTACTTAAACAGTTATAGTCACCATCACCTGCTTCAGAATGGTCTT
TTAGATTTGTGTTTGTTTTGTTAAAGTTGTTGGCACCAGGATGCAGAGAATCAGACTGGCCTGAGGTGAAGGAGCACACAGCCCTGAGGG
CTTGGAACCCTGGGTCCAGTTCCTCTTCACACCCCCTTCCACTCTGAGTAGCACATCTCCCCAGGTGCCCATGGAACACCTGCTTTCATC
CCAAATATCCGTCCACCTAGGCGGGGTGGTATGTTCTTACGTCTCTCTGACTTTGATGCCACTCATTCTATAGTTTAGCTGGTTTTCGTT
CAAGATATTCTTGGTAGTAACTGACAAGTATGTTGCACATGTATTGGGGGAGGCGCTTCATTTTTATTTTAATACACATGTATTTCCTCC
TTGCACAGGATTTTGATGGTGTGGGAATATCCTAAGTGGTAGCCTTCCAAGTAGCAGTGAGTTGACATTCAGCTGCTTTTAACTATTCAG
GCTACCTTTTATACTAAACCTTGAAAACTAGAATCTAATGTCTACCCCAAAAAAGTAGTTCTTTGATATTTTATACTTTTTATGTACCAT
GTCAGAAAGAGTATGTTGGCGTTTGTCATGGGACTCATTTCACATAATAGAATGCCTAGTCTCATTGACCAATCGTTAAAAAATCATATT
TGTGTGTCTTAAGATTCATATTTATATGTTCTCTCAAATGTATGTCTCTTACGTAACATACTCTAAGAATGAAACTGTCACCACAGGTAA
ATCCTTGTTAGCAAGGAATCTGTCTGCTCCAGTCTACTCCTAGTTTGATCCTTGGATGTAAGAACCAAGTCATTACATGTCAAATTCAAT
TTTTCTGCCTTAAGAATGAATGTCCTTCATAAAATATTGGATGCAGTGTAACACTATCCAAGGCAGTGACTTCAGCTTTATATACATATA
AAATATAGTTAGTTTTAAAATTATTGACATTTATTTAAACTTTTAGATTGGATTGTTTGCTATTGCTCTGTGTGAGGATACATAATCTTT
CAGTAAACTGTATTTTTAACTTTTCCATAAGCTGATTTTGGTTCATTTTATCAACGTAAGCACACCCTGTTCATAGGGAAAATAAACCTT
GGGTTATAAGCATTAGCCTGAGGACAATGAAGCCACTTAACCTAATTTATGCTTTCGACTGTTCTGTTTCCAGAGAGGAAAGCCTTTACA
AATTACTCTCAGTTCTTTAGGGGCAGAAGGCTTGTTTCAAGAGGTTTGACAGAAGAAAGGAATATATGAACTTAATGAGATGTCGACTTG
GTTCAGGTCTAAAAATGAGGGCAAAACACTAAGGCTCTAGCAGTGACTTGTTCACTAAAAAGAGAGAGTCCTGTCCCCAGACGGTTAGTA
CAAAGCCTTGGATACAGTTTGCTTGTAATATTTTTAATAATGTGAGGAGTACAGTGTTTTCTAATTCATTCAAGTATATATGATTTAAAC
CTGGGCTACTGACACACACACAGTAGCCATTAGTTAGACTCTTCTTAGTGAATATCAGGAACATCCCATCTGTGCTTAACCAGAATCCAG
CAAGTCAGCACACAAGTGATTTTATTGTTATTTTGTTGTATTTACTTGCATTTGTTGTATTTACTTTCATCTGCAGCATTTGGAGTTTAA
AAATAATGTAAAGGGTTCTAGTAGAAATAGTGTCCTAAGGCCAATTACCTACCATACTAACAATCAGCAGATAAAATTCTGGACGTGAGA
TTCCTTATAATCTAATTATACCTGAGGTTGAGCAAGAAATGTCTTCCTTTAGAAAATCTCATTCAAGTCAGGTTCTTCTCTACAGTTCAA
AATTGAGAATGGATTTAATTAACTAGCATTTAGCCAGCTTTTTCTTGCCCTTGGAGAAAAAGAATCATTCTCAACCTGATAATCTGTTAA
GAAAAATCCCATATGAACAATCTGGTCATTAACATACATATGATACGGAGTCTCTTTGTTGTCACCAAGTGAACATACTTCTCATGGTGG
GTTGGACAGTAATACATGTTAGAGGGTCAGAAGCTTCTGGTTTCTGCTGTTTGCTTTAAATACCCTTGGGGTTTTTTTTTAAACCCTTAC
AAGGGGAGCATCAGCTTTGGAAAGTGTGACTCTGTAGGAGTGTAGAAGGCAGTGGTGTATGATCTTAGCCTCGTCCTGATGCCTGAATCC
AGCCAGCTGTTGCTCTGACCCACAGCAATAGAGCAAGTTACCCATCACCAGCATTTGTACAGAGCAGGGAATTCTGGTTTTAGTCCATTG
GTAGCATTGTGTGTATGAGGAGATTCAACACCACAGACAGCTGCAGGACTCGATATCCATGGCTTCTTTCCATCACAAAACGGGTAGAAA
CACATTCACTGCTTCAGGGTTCTAATCTGTGTGTCTCCTTATGACTCCATTTCTGTAAGCTACTCTGTAACTTTGATATATGCTGTATTT
TCTTTCTTTAAAAGATTTAGATGTTTTTTCAGCAAGCTAGCCATACAACCATTGTATCTCTTTCTCTTCAGTATGGTTTAGAGCCCAGAT
CAGTTAGTAGGCTTTCGTTGTCTTCTCTTTCAATACATGTACATCTTTACTGTTTGAAAAGTGTTACAGCTGTCAAAGAATCTTCATGGA
CCTGAAGATAATTTCTTGTGAAGTTGAATGCAAGTGTACTGTCATTCATAGTGTTTATATCAAAATACCAGGAATCTTCACTTTTGCTAC

>3498_3498_6_AKT3-DESI2_AKT3_chr1_244006427_ENST00000366539_DESI2_chr1_244849899_ENST00000302550_length(amino acids)=178AA_BP=0
MNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKT3-DESI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKT3-DESI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKT3-DESI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource