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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GSAP-STYXL1 (FusionGDB2 ID:34986)

Fusion Gene Summary for GSAP-STYXL1

Fusion gene summary

Fusion gene information	Fusion gene name: GSAP-STYXL1
	Fusion gene ID: 34986
		Hgene	Tgene
	Gene symbol	GSAP	STYXL1
	Gene ID	54103	51657
	Gene name	gamma-secretase activating protein	serine/threonine/tyrosine interacting like 1
	Synonyms	PION	DUSP24\|MK-STYX\|MKSTYX
	Cytomap	7q11.23	7q11.23
	Type of gene	protein-coding	protein-coding
	Description	gamma-secretase-activating proteinpigeon homologprotein pigeon homolog	serine/threonine/tyrosine-interacting-like protein 1dual specificity phosphatase 24 (putative)dual specificity phosphatase inhibitor MK-STYXdual specificity protein phosphatase 24inactive dual specificity protein phosphatase MK-STYXmap kinase phospha
	Modification date	20200313	20200313
	UniProtAcc	A4D1B5	.
	Ensembl transtripts involved in fusion gene	ENST00000257626, ENST00000430584, ENST00000440473, ENST00000441833,	ENST00000460184, ENST00000248600, ENST00000340062, ENST00000359697, ENST00000360591, ENST00000431581, ENST00000451157,
Fusion gene scores	* DoF score	4 X 4 X 4=64	8 X 7 X 6=336
	# samples	4	9
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GSAP [Title/Abstract] AND STYXL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GSAP(77006165)-STYXL1(75634722), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GSAP	GO:0030162	regulation of proteolysis	20811458
Hgene	GSAP	GO:1902004	positive regulation of amyloid-beta formation	20811458
Tgene	STYXL1	GO:0032515	negative regulation of phosphoprotein phosphatase activity	24709986

Fusion gene breakpoints across GSAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STYXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0130-01A	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-

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Fusion Gene ORF analysis for GSAP-STYXL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000257626	ENST00000460184	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
In-frame	ENST00000257626	ENST00000248600	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
In-frame	ENST00000257626	ENST00000340062	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
In-frame	ENST00000257626	ENST00000359697	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
In-frame	ENST00000257626	ENST00000360591	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
In-frame	ENST00000257626	ENST00000431581	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
In-frame	ENST00000257626	ENST00000451157	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000430584	ENST00000248600	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000430584	ENST00000340062	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000430584	ENST00000359697	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000430584	ENST00000360591	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000430584	ENST00000431581	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000430584	ENST00000451157	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000440473	ENST00000248600	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000440473	ENST00000340062	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000440473	ENST00000359697	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000440473	ENST00000360591	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000440473	ENST00000431581	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000440473	ENST00000451157	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000441833	ENST00000248600	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000441833	ENST00000340062	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000441833	ENST00000359697	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000441833	ENST00000360591	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000441833	ENST00000431581	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-3CDS	ENST00000441833	ENST00000451157	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-intron	ENST00000430584	ENST00000460184	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-intron	ENST00000440473	ENST00000460184	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-
intron-intron	ENST00000441833	ENST00000460184	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000257626	GSAP	chr7	77006165	-	ENST00000248600	STYXL1	chr7	75634722	-	1439	820	79	1308	409
ENST00000257626	GSAP	chr7	77006165	-	ENST00000359697	STYXL1	chr7	75634722	-	1435	820	79	1308	409
ENST00000257626	GSAP	chr7	77006165	-	ENST00000340062	STYXL1	chr7	75634722	-	1435	820	79	1308	409
ENST00000257626	GSAP	chr7	77006165	-	ENST00000360591	STYXL1	chr7	75634722	-	1434	820	79	1308	409
ENST00000257626	GSAP	chr7	77006165	-	ENST00000431581	STYXL1	chr7	75634722	-	1368	820	79	1308	409
ENST00000257626	GSAP	chr7	77006165	-	ENST00000451157	STYXL1	chr7	75634722	-	1767	820	79	1215	378

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000257626	ENST00000248600	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-	0.000267806	0.9997322
ENST00000257626	ENST00000359697	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-	0.000276441	0.9997235
ENST00000257626	ENST00000340062	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-	0.000276441	0.9997235
ENST00000257626	ENST00000360591	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-	0.000274652	0.9997253
ENST00000257626	ENST00000431581	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-	0.000275126	0.9997248
ENST00000257626	ENST00000451157	GSAP	chr7	77006165	-	STYXL1	chr7	75634722	-	0.000250557	0.9997495

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Fusion Genomic Features for GSAP-STYXL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GSAP-STYXL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:77006165/chr7:75634722)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GSAP A4D1B5	.
FUNCTION: Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269\|PubMed:20811458}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000248600

159_302

151

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000340062

159_302

218.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000359697

159_302

151

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000431581

159_302

151

314.0

Domain

Tyrosine-protein phosphatase

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000248600

27_138

151

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000340062

27_138

218.0

Domain

Rhodanese

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000359697

27_138

151

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:77006165

chr7:75634722

ENST00000431581

27_138

151

314.0

Domain

Rhodanese

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Fusion Gene Sequence for GSAP-STYXL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34986_34986_1_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000248600_length(transcript)=1439nt_BP=820nt
CGAGGGCGAGGCGGCCACGCGGGGCCGGGAATGCCCGCGGTGCGGGGCCCCAGAGCCGCCCGGTGGTCGTGTCCGGGCGATGGCTCTTCG
CCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGGCAGTGTCGGAGGCCAGCGGGGCCGGAAGCGG
CGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACATGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGA
TAAGGGAAATGTCGTCTTTGGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCAG
TTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAGGAACGAACTTCAACCAGGATC
AAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAGGTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCT
CTACCCACATATTGAAAGTCATCCTCTTCCAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGT
CGCCCAAGAAGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTTTGGGCTCAGTG
GGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAAAATGTATCCAGTTTTATGCTGATGAGAGCTA
TAACTTAATGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGA
CCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCT
TCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCT
TGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGAC
CTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAA
GACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACC

>34986_34986_1_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000248600_length(amino acids)=409AA_BP=0
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDL
QVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMELDAFQPYPIEIVPGKVFVGNFS
QACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS

--------------------------------------------------------------
>34986_34986_2_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000340062_length(transcript)=1435nt_BP=820nt
CGAGGGCGAGGCGGCCACGCGGGGCCGGGAATGCCCGCGGTGCGGGGCCCCAGAGCCGCCCGGTGGTCGTGTCCGGGCGATGGCTCTTCG
CCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGGCAGTGTCGGAGGCCAGCGGGGCCGGAAGCGG
CGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACATGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGA
TAAGGGAAATGTCGTCTTTGGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCAG
TTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAGGAACGAACTTCAACCAGGATC
AAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAGGTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCT
CTACCCACATATTGAAAGTCATCCTCTTCCAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGT
CGCCCAAGAAGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTTTGGGCTCAGTG
GGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAAAATGTATCCAGTTTTATGCTGATGAGAGCTA
TAACTTAATGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGA
CCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCT
TCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCT
TGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGAC
CTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAA
GACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACC

>34986_34986_2_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000340062_length(amino acids)=409AA_BP=0
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDL
QVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMELDAFQPYPIEIVPGKVFVGNFS
QACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS

--------------------------------------------------------------
>34986_34986_3_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000359697_length(transcript)=1435nt_BP=820nt
CGAGGGCGAGGCGGCCACGCGGGGCCGGGAATGCCCGCGGTGCGGGGCCCCAGAGCCGCCCGGTGGTCGTGTCCGGGCGATGGCTCTTCG
CCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGGCAGTGTCGGAGGCCAGCGGGGCCGGAAGCGG
CGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACATGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGA
TAAGGGAAATGTCGTCTTTGGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCAG
TTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAGGAACGAACTTCAACCAGGATC
AAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAGGTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCT
CTACCCACATATTGAAAGTCATCCTCTTCCAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGT
CGCCCAAGAAGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTTTGGGCTCAGTG
GGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAAAATGTATCCAGTTTTATGCTGATGAGAGCTA
TAACTTAATGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGA
CCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCT
TCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCT
TGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGAC
CTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAA
GACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACC

>34986_34986_3_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000359697_length(amino acids)=409AA_BP=0
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDL
QVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMELDAFQPYPIEIVPGKVFVGNFS
QACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS

--------------------------------------------------------------
>34986_34986_4_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000360591_length(transcript)=1434nt_BP=820nt
CGAGGGCGAGGCGGCCACGCGGGGCCGGGAATGCCCGCGGTGCGGGGCCCCAGAGCCGCCCGGTGGTCGTGTCCGGGCGATGGCTCTTCG
CCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGGCAGTGTCGGAGGCCAGCGGGGCCGGAAGCGG
CGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACATGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGA
TAAGGGAAATGTCGTCTTTGGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCAG
TTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAGGAACGAACTTCAACCAGGATC
AAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAGGTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCT
CTACCCACATATTGAAAGTCATCCTCTTCCAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGT
CGCCCAAGAAGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTTTGGGCTCAGTG
GGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAAAATGTATCCAGTTTTATGCTGATGAGAGCTA
TAACTTAATGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGA
CCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCT
TCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCT
TGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGAC
CTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAA
GACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACC

>34986_34986_4_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000360591_length(amino acids)=409AA_BP=0
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDL
QVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMELDAFQPYPIEIVPGKVFVGNFS
QACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS

--------------------------------------------------------------
>34986_34986_5_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000431581_length(transcript)=1368nt_BP=820nt
CGAGGGCGAGGCGGCCACGCGGGGCCGGGAATGCCCGCGGTGCGGGGCCCCAGAGCCGCCCGGTGGTCGTGTCCGGGCGATGGCTCTTCG
CCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGGCAGTGTCGGAGGCCAGCGGGGCCGGAAGCGG
CGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACATGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGA
TAAGGGAAATGTCGTCTTTGGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCAG
TTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAGGAACGAACTTCAACCAGGATC
AAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAGGTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCT
CTACCCACATATTGAAAGTCATCCTCTTCCAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGT
CGCCCAAGAAGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTTTGGGCTCAGTG
GGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAAAATGTATCCAGTTTTATGCTGATGAGAGCTA
TAACTTAATGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGA
CCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCT
TCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCT
TGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGAC
CTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAA
GACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACC

>34986_34986_5_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000431581_length(amino acids)=409AA_BP=0
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDL
QVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMELDAFQPYPIEIVPGKVFVGNFS
QACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS

--------------------------------------------------------------
>34986_34986_6_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000451157_length(transcript)=1767nt_BP=820nt
CGAGGGCGAGGCGGCCACGCGGGGCCGGGAATGCCCGCGGTGCGGGGCCCCAGAGCCGCCCGGTGGTCGTGTCCGGGCGATGGCTCTTCG
CCTGGTCGCCGACTTCGACCTCGGGAAGGACGTGCTCCCGTGGTTGCGGGCGCAGCGGGCAGTGTCGGAGGCCAGCGGGGCCGGAAGCGG
CGGCGCAGATGTTTTAGAAAACGATTATGAGAGCTTACATGTATTAAATGTTGAAAGAAATGGAAATATTATTTATACCTATAAGGATGA
TAAGGGAAATGTCGTCTTTGGATTATATGATTGTCAAACCAGACAAAATGAGCTTCTATATACCTTTGAGAAAGACTTGCAAGTTTTCAG
TTGCTCTGTCAACAGTGAAAGGACTTTGCTTGCTGCAAGTTTAGTTCAGTCTACTAAAGAAGGAAAAAGGAACGAACTTCAACCAGGATC
AAAGTGCTTGACTTTGTTGGTTGAAATCCACCCTGTTAACAATGTGAAGGTTCTAAAGGCTGTGGATAGCTATATTTGGGTTCAGTTTCT
CTACCCACATATTGAAAGTCATCCTCTTCCAGAGAACCATCTGTTACTGATTTCAGAAGAGAAATATATTGAACAATTTCGTATCCATGT
CGCCCAAGAAGATGGAAATAGAGTGGTGATTAAAAATTCTGGCCATCTCCCAAGAGACAGAATAGCTGAGGATTTCGTTTGGGCTCAGTG
GGATATGTCAGAACAGAGATTATATTACATTGACCTGAAGAAATCAAGGAGTATCTTAAAATGTATCCAGTTTTATGCTGATGAGAGCTA
TAACTTAATGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGA
CCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCT
TCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCT
TGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGAC
CTTGCAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTAGCACAATCTCGACTCACTGCAAGCTCTGCCTCCCGGGCTCATGCC
ATTCTTCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGCATCTGCCACCACTCAATTTCTTTAATATATGTAGGCCTATTCAGATTGT
CTGTTTCTTCTTGTGTGAGTTTTGGCAGTCTGTGTCTTTCAAGGAATTGATCAATCACATTTGTGGATATGAATATTCTTCTATTATCCT
TTTAATGTCTGTGGGATCTGTAGCAATGTCTTCTCTTTCACTTCTGTATTAGTAATTTGTGTCTTCTGTTTAAGTTAGCCTGGCTAGCGG
TGTATCGATTTTATTGATCTTTTCAAAGAACCGGCTTTTGGTTTTTTTGATTTTCTCTATTGATTTCCTGTTTTCAATTTCATTCTTTGC
ATGGCGTATCTAGTTTTCCTAGCACCATTTGTTGAAATGACTGTCCTTTTCCCCCATCGAATGGTCTTGGCATACTATCAAAAATTCCTT

>34986_34986_6_GSAP-STYXL1_GSAP_chr7_77006165_ENST00000257626_STYXL1_chr7_75634722_ENST00000451157_length(amino acids)=378AA_BP=0
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDL
QVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQF
RIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMELDAFQPYPIEIVPGKVFVGNFS
QACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GSAP-STYXL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GSAP-STYXL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GSAP-STYXL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source