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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GSDMB-NT5C3B (FusionGDB2 ID:34988)

Fusion Gene Summary for GSDMB-NT5C3B

Fusion gene summary

Fusion gene information	Fusion gene name: GSDMB-NT5C3B
	Fusion gene ID: 34988
		Hgene	Tgene
	Gene symbol	GSDMB	NT5C3B
	Gene ID	55876	115024
	Gene name	gasdermin B	5'-nucleotidase, cytosolic IIIB
	Synonyms	GSDMB-1\|GSDML\|PP4052\|PRO2521	NT5C3L\|cN-IIIB
	Cytomap	17q21.1	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	gasdermin-Bgasdermin-like proteingasderminB-1	7-methylguanosine phosphate-specific 5'-nucleotidase5'-nucleotidase, cytosolic III-like7-methylguanosine nucleotidaseN(7)-methylguanylate 5'-phosphatasecN-III-like proteincytosolic 5'-nucleotidase 3Bcytosolic 5'-nucleotidase III-like protein
	Modification date	20200313	20200320
	UniProtAcc	Q8TAX9	.
	Ensembl transtripts involved in fusion gene	ENST00000309481, ENST00000360317, ENST00000394175, ENST00000394179, ENST00000418519, ENST00000520542,	ENST00000435506, ENST00000521789, ENST00000269534,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 5 X 4=100
	# samples	2	5
	** MAII score	log2(2/8*10)=1.32192809488736	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GSDMB [Title/Abstract] AND NT5C3B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GSDMB(38066009)-NT5C3B(39983878), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GSDMB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NT5C3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A92D-01A	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-

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Fusion Gene ORF analysis for GSDMB-NT5C3B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000309481	ENST00000435506	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000309481	ENST00000521789	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000360317	ENST00000435506	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000360317	ENST00000521789	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000394175	ENST00000435506	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000394175	ENST00000521789	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000394179	ENST00000435506	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000394179	ENST00000521789	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000418519	ENST00000435506	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000418519	ENST00000521789	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000520542	ENST00000435506	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
5CDS-intron	ENST00000520542	ENST00000521789	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
In-frame	ENST00000309481	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
In-frame	ENST00000360317	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
In-frame	ENST00000394175	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
In-frame	ENST00000394179	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
In-frame	ENST00000418519	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-
In-frame	ENST00000520542	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360317	GSDMB	chr17	38066009	-	ENST00000269534	NT5C3B	chr17	39983878	-	1352	576	0	911	303
ENST00000394175	GSDMB	chr17	38066009	-	ENST00000269534	NT5C3B	chr17	39983878	-	1576	800	224	1135	303
ENST00000309481	GSDMB	chr17	38066009	-	ENST00000269534	NT5C3B	chr17	39983878	-	1423	647	71	982	303
ENST00000520542	GSDMB	chr17	38066009	-	ENST00000269534	NT5C3B	chr17	39983878	-	1459	683	107	1018	303
ENST00000418519	GSDMB	chr17	38066009	-	ENST00000269534	NT5C3B	chr17	39983878	-	1483	707	131	1042	303
ENST00000394179	GSDMB	chr17	38066009	-	ENST00000269534	NT5C3B	chr17	39983878	-	1483	707	131	1042	303

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360317	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-	0.001893743	0.99810624
ENST00000394175	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-	0.001587055	0.99841297
ENST00000309481	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-	0.002023506	0.9979765
ENST00000520542	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-	0.002123312	0.99787664
ENST00000418519	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-	0.002043638	0.9979564
ENST00000394179	ENST00000269534	GSDMB	chr17	38066009	-	NT5C3B	chr17	39983878	-	0.002043638	0.9979564

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Fusion Genomic Features for GSDMB-NT5C3B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GSDMB-NT5C3B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38066009/chr17:39983878)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GSDMB Q8TAX9	.
FUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). {ECO:0000269\|PubMed:32299851}.; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells (PubMed:27281216, PubMed:32299851). Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form (PubMed:32299851). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32299851). Binds to membrane inner leaflet lipids, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid (PubMed:28154144). Also binds sufatide, a component of the apical membrane of epithelial cells (PubMed:28154144). {ECO:0000269\|PubMed:27281216, ECO:0000269\|PubMed:28154144, ECO:0000269\|PubMed:32299851}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000309481

243_271

192

404.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000360317

243_271

192

417.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000394175

243_271

192

395.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000394179

243_271

192

412.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000418519

243_271

192

417.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000520542

243_271

192

408.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000309481

1_275

192

404.0

Region

Triggers pyroptosis

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000360317

1_275

192

417.0

Region

Triggers pyroptosis

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000394175

1_275

192

395.0

Region

Triggers pyroptosis

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000394179

1_275

192

412.0

Region

Triggers pyroptosis

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000418519

1_275

192

417.0

Region

Triggers pyroptosis

Hgene

GSDMB

chr17:38066009

chr17:39983878

ENST00000520542

1_275

192

408.0

Region

Triggers pyroptosis

Tgene

NT5C3B

chr17:38066009

chr17:39983878

ENST00000269534

156_157

181

293.0

Region

Substrate binding

Tgene

NT5C3B

chr17:38066009

chr17:39983878

ENST00000435506

156_157

189

301.0

Region

Substrate binding

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Fusion Gene Sequence for GSDMB-NT5C3B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34988_34988_1_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000309481_NT5C3B_chr17_39983878_ENST00000269534_length(transcript)=1423nt_BP=647nt
ATCTGTGGGGATTCTCACAACTTCCATTTCTGGTGAACAGCTGAGGTCAGAGAGGAGTTGGTCCAGGCGCAATGTTCAGCGTATTTGAGG
AAATCACAAGAATTGTAGTTAAGGAGATGGATGCTGGAGGGGATATGATTGCCGTTAGAAGCCTTGTTGATGCTGATAGATTCCGCTGCT
TCCATCTGGTGGGGGAGAAGAGAACTTTCTTTGGATGCCGGCACTACACAACAGGCCTCACCCTGATGGACATTCTGGACACAGATGGGG
ACAAGTGGTTAGATGAACTGGATTCTGGGCTCCAAGGTCAAAAGGCTGAGTTTCAAATTCTGGATAATGTAGACTCAACGGGAGAGTTGA
TAGTGAGATTACCCAAAGAAATAACAATTTCAGGCAGTTTCCAGGGCTTCCACCATCAGAAAATCAAGATATCGGAGAACCGGATATCCC
AGCAGTATCTGGCTACCCTTGAAAACAGGAAGCTGAAGAGGGAACTACCCTTTTCATTCCGATCAATTAATACGAGAGAAAACCTGTATC
TGGTGACAGAAACTCTGGAGACGGTAAAGGAGGAAACCCTGAAAAGCGACCGGCAATATAAATTTTGGAGCCAGATCTCTCAGGGCCATC
TCAGCTATAAACACAAGGGTTTTCTCCAGGGATTTAAGGGCCAGCTCATACACACATACAACAAGAACAGCTCTGCGTGTGAGAACTCTG
GTTACTTCCAGCAACTTGAGGGCAAAACCAATGTCATCCTGCTGGGAGACTCTATCGGGGACCTCACCATGGCCGATGGGGTTCCTGGTG
TGCAGAACATTCTCAAAATTGGCTTCCTGAATGACAAGGTGGAGGAGCGGCGGGAGCGCTACATGGACTCCTATGACATCGTGCTGGAGA
AGGACGAGACTCTGGATGTGGTCAACGGGCTACTGCAGCACATCCTGTGCCAGGGGGTCCAGCTGGAGATGCAAGGCCCCTGAAGGCGCA
GGCTCCAGCCCGGCCTGCAGGCCGTGGTGAGGAGGGGCGCCTCCCCAGAGTCTGCTCCCCCGTGAACACAGAGCAGAGGCCAGGGTGGCC
AGCAGTGGCTGGGTCCTTCCGCGCCCCTCCGTCCTCCTTTCCCTGAGCACCTTCATCACCAGAGGCTTGAAGGAACCCCGCCATGTGGCA
GGGCACAGGCACTGTTCCTGGTGAACCTTGGACCACAGCATGTCAGTGCTCTAGGGATTGTCTACTCCAGGGATTTTCTTCAAAATTTTT
AAACATGGGAAGTTCAAACAAATATAATGTGTGAAACAGATCAAAATTTTTAAAATGAAAAAAAAGCTGCTCTGATTCAGGGGATGTGGG

>34988_34988_1_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000309481_NT5C3B_chr17_39983878_ENST00000269534_length(amino acids)=303AA_BP=192
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNV
DSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWS
QISQGHLSYKHKGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDS

--------------------------------------------------------------
>34988_34988_2_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000360317_NT5C3B_chr17_39983878_ENST00000269534_length(transcript)=1352nt_BP=576nt
ATGTTCAGCGTATTTGAGGAAATCACAAGAATTGTAGTTAAGGAGATGGATGCTGGAGGGGATATGATTGCCGTTAGAAGCCTTGTTGAT
GCTGATAGATTCCGCTGCTTCCATCTGGTGGGGGAGAAGAGAACTTTCTTTGGATGCCGGCACTACACAACAGGCCTCACCCTGATGGAC
ATTCTGGACACAGATGGGGACAAGTGGTTAGATGAACTGGATTCTGGGCTCCAAGGTCAAAAGGCTGAGTTTCAAATTCTGGATAATGTA
GACTCAACGGGAGAGTTGATAGTGAGATTACCCAAAGAAATAACAATTTCAGGCAGTTTCCAGGGCTTCCACCATCAGAAAATCAAGATA
TCGGAGAACCGGATATCCCAGCAGTATCTGGCTACCCTTGAAAACAGGAAGCTGAAGAGGGAACTACCCTTTTCATTCCGATCAATTAAT
ACGAGAGAAAACCTGTATCTGGTGACAGAAACTCTGGAGACGGTAAAGGAGGAAACCCTGAAAAGCGACCGGCAATATAAATTTTGGAGC
CAGATCTCTCAGGGCCATCTCAGCTATAAACACAAGGGTTTTCTCCAGGGATTTAAGGGCCAGCTCATACACACATACAACAAGAACAGC
TCTGCGTGTGAGAACTCTGGTTACTTCCAGCAACTTGAGGGCAAAACCAATGTCATCCTGCTGGGAGACTCTATCGGGGACCTCACCATG
GCCGATGGGGTTCCTGGTGTGCAGAACATTCTCAAAATTGGCTTCCTGAATGACAAGGTGGAGGAGCGGCGGGAGCGCTACATGGACTCC
TATGACATCGTGCTGGAGAAGGACGAGACTCTGGATGTGGTCAACGGGCTACTGCAGCACATCCTGTGCCAGGGGGTCCAGCTGGAGATG
CAAGGCCCCTGAAGGCGCAGGCTCCAGCCCGGCCTGCAGGCCGTGGTGAGGAGGGGCGCCTCCCCAGAGTCTGCTCCCCCGTGAACACAG
AGCAGAGGCCAGGGTGGCCAGCAGTGGCTGGGTCCTTCCGCGCCCCTCCGTCCTCCTTTCCCTGAGCACCTTCATCACCAGAGGCTTGAA
GGAACCCCGCCATGTGGCAGGGCACAGGCACTGTTCCTGGTGAACCTTGGACCACAGCATGTCAGTGCTCTAGGGATTGTCTACTCCAGG
GATTTTCTTCAAAATTTTTAAACATGGGAAGTTCAAACAAATATAATGTGTGAAACAGATCAAAATTTTTAAAATGAAAAAAAAGCTGCT
CTGATTCAGGGGATGTGGGTGGGGGTAGAACCTGGACCTCTTGGCCCTGGGGGCACATGGGATGCTTCTAGGAACACAGTTTGAGAACCA

>34988_34988_2_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000360317_NT5C3B_chr17_39983878_ENST00000269534_length(amino acids)=303AA_BP=192
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNV
DSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWS
QISQGHLSYKHKGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDS

--------------------------------------------------------------
>34988_34988_3_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000394175_NT5C3B_chr17_39983878_ENST00000269534_length(transcript)=1576nt_BP=800nt
GTGGAATGTCATCAGTTAAGGCTATTTTCATTTCTTTTGTGGATCTTCAGTTGCTTCAGGCCATCTGGATGTATACATGCAGGTCACAGG
GAATATGATGGCTTAGCTTGGGTTCAGAGGCCTGACACCTCAGGCTGCCAAATGTGGAAGATTTAAATACTTGAACCAATACCCTCCTCC
CAAAAACTGAAATTGGCTTCTGTTTCTGAGTTGGTCCAGGCGCAATGTTCAGCGTATTTGAGGAAATCACAAGAATTGTAGTTAAGGAGA
TGGATGCTGGAGGGGATATGATTGCCGTTAGAAGCCTTGTTGATGCTGATAGATTCCGCTGCTTCCATCTGGTGGGGGAGAAGAGAACTT
TCTTTGGATGCCGGCACTACACAACAGGCCTCACCCTGATGGACATTCTGGACACAGATGGGGACAAGTGGTTAGATGAACTGGATTCTG
GGCTCCAAGGTCAAAAGGCTGAGTTTCAAATTCTGGATAATGTAGACTCAACGGGAGAGTTGATAGTGAGATTACCCAAAGAAATAACAA
TTTCAGGCAGTTTCCAGGGCTTCCACCATCAGAAAATCAAGATATCGGAGAACCGGATATCCCAGCAGTATCTGGCTACCCTTGAAAACA
GGAAGCTGAAGAGGGAACTACCCTTTTCATTCCGATCAATTAATACGAGAGAAAACCTGTATCTGGTGACAGAAACTCTGGAGACGGTAA
AGGAGGAAACCCTGAAAAGCGACCGGCAATATAAATTTTGGAGCCAGATCTCTCAGGGCCATCTCAGCTATAAACACAAGGGTTTTCTCC
AGGGATTTAAGGGCCAGCTCATACACACATACAACAAGAACAGCTCTGCGTGTGAGAACTCTGGTTACTTCCAGCAACTTGAGGGCAAAA
CCAATGTCATCCTGCTGGGAGACTCTATCGGGGACCTCACCATGGCCGATGGGGTTCCTGGTGTGCAGAACATTCTCAAAATTGGCTTCC
TGAATGACAAGGTGGAGGAGCGGCGGGAGCGCTACATGGACTCCTATGACATCGTGCTGGAGAAGGACGAGACTCTGGATGTGGTCAACG
GGCTACTGCAGCACATCCTGTGCCAGGGGGTCCAGCTGGAGATGCAAGGCCCCTGAAGGCGCAGGCTCCAGCCCGGCCTGCAGGCCGTGG
TGAGGAGGGGCGCCTCCCCAGAGTCTGCTCCCCCGTGAACACAGAGCAGAGGCCAGGGTGGCCAGCAGTGGCTGGGTCCTTCCGCGCCCC
TCCGTCCTCCTTTCCCTGAGCACCTTCATCACCAGAGGCTTGAAGGAACCCCGCCATGTGGCAGGGCACAGGCACTGTTCCTGGTGAACC
TTGGACCACAGCATGTCAGTGCTCTAGGGATTGTCTACTCCAGGGATTTTCTTCAAAATTTTTAAACATGGGAAGTTCAAACAAATATAA
TGTGTGAAACAGATCAAAATTTTTAAAATGAAAAAAAAGCTGCTCTGATTCAGGGGATGTGGGTGGGGGTAGAACCTGGACCTCTTGGCC

>34988_34988_3_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000394175_NT5C3B_chr17_39983878_ENST00000269534_length(amino acids)=303AA_BP=192
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNV
DSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWS
QISQGHLSYKHKGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDS

--------------------------------------------------------------
>34988_34988_4_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000394179_NT5C3B_chr17_39983878_ENST00000269534_length(transcript)=1483nt_BP=707nt
ACAACTTTCAGTTTCATTATTTTAGCTTCCTGAGATTCAGAGGCCAGGAACTGTGCAGAGATCTGTGGGGATTCTCACAACTTCCATTTC
TGGTGAACAGCTGAGGTCAGAGAGGAGTTGGTCCAGGCGCAATGTTCAGCGTATTTGAGGAAATCACAAGAATTGTAGTTAAGGAGATGG
ATGCTGGAGGGGATATGATTGCCGTTAGAAGCCTTGTTGATGCTGATAGATTCCGCTGCTTCCATCTGGTGGGGGAGAAGAGAACTTTCT
TTGGATGCCGGCACTACACAACAGGCCTCACCCTGATGGACATTCTGGACACAGATGGGGACAAGTGGTTAGATGAACTGGATTCTGGGC
TCCAAGGTCAAAAGGCTGAGTTTCAAATTCTGGATAATGTAGACTCAACGGGAGAGTTGATAGTGAGATTACCCAAAGAAATAACAATTT
CAGGCAGTTTCCAGGGCTTCCACCATCAGAAAATCAAGATATCGGAGAACCGGATATCCCAGCAGTATCTGGCTACCCTTGAAAACAGGA
AGCTGAAGAGGGAACTACCCTTTTCATTCCGATCAATTAATACGAGAGAAAACCTGTATCTGGTGACAGAAACTCTGGAGACGGTAAAGG
AGGAAACCCTGAAAAGCGACCGGCAATATAAATTTTGGAGCCAGATCTCTCAGGGCCATCTCAGCTATAAACACAAGGGTTTTCTCCAGG
GATTTAAGGGCCAGCTCATACACACATACAACAAGAACAGCTCTGCGTGTGAGAACTCTGGTTACTTCCAGCAACTTGAGGGCAAAACCA
ATGTCATCCTGCTGGGAGACTCTATCGGGGACCTCACCATGGCCGATGGGGTTCCTGGTGTGCAGAACATTCTCAAAATTGGCTTCCTGA
ATGACAAGGTGGAGGAGCGGCGGGAGCGCTACATGGACTCCTATGACATCGTGCTGGAGAAGGACGAGACTCTGGATGTGGTCAACGGGC
TACTGCAGCACATCCTGTGCCAGGGGGTCCAGCTGGAGATGCAAGGCCCCTGAAGGCGCAGGCTCCAGCCCGGCCTGCAGGCCGTGGTGA
GGAGGGGCGCCTCCCCAGAGTCTGCTCCCCCGTGAACACAGAGCAGAGGCCAGGGTGGCCAGCAGTGGCTGGGTCCTTCCGCGCCCCTCC
GTCCTCCTTTCCCTGAGCACCTTCATCACCAGAGGCTTGAAGGAACCCCGCCATGTGGCAGGGCACAGGCACTGTTCCTGGTGAACCTTG
GACCACAGCATGTCAGTGCTCTAGGGATTGTCTACTCCAGGGATTTTCTTCAAAATTTTTAAACATGGGAAGTTCAAACAAATATAATGT
GTGAAACAGATCAAAATTTTTAAAATGAAAAAAAAGCTGCTCTGATTCAGGGGATGTGGGTGGGGGTAGAACCTGGACCTCTTGGCCCTG

>34988_34988_4_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000394179_NT5C3B_chr17_39983878_ENST00000269534_length(amino acids)=303AA_BP=192
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNV
DSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWS
QISQGHLSYKHKGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDS

--------------------------------------------------------------
>34988_34988_5_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000418519_NT5C3B_chr17_39983878_ENST00000269534_length(transcript)=1483nt_BP=707nt
ACAACTTTCAGTTTCATTATTTTAGCTTCCTGAGATTCAGAGGCCAGGAACTGTGCAGAGATCTGTGGGGATTCTCACAACTTCCATTTC
TGGTGAACAGCTGAGGTCAGAGAGGAGTTGGTCCAGGCGCAATGTTCAGCGTATTTGAGGAAATCACAAGAATTGTAGTTAAGGAGATGG
ATGCTGGAGGGGATATGATTGCCGTTAGAAGCCTTGTTGATGCTGATAGATTCCGCTGCTTCCATCTGGTGGGGGAGAAGAGAACTTTCT
TTGGATGCCGGCACTACACAACAGGCCTCACCCTGATGGACATTCTGGACACAGATGGGGACAAGTGGTTAGATGAACTGGATTCTGGGC
TCCAAGGTCAAAAGGCTGAGTTTCAAATTCTGGATAATGTAGACTCAACGGGAGAGTTGATAGTGAGATTACCCAAAGAAATAACAATTT
CAGGCAGTTTCCAGGGCTTCCACCATCAGAAAATCAAGATATCGGAGAACCGGATATCCCAGCAGTATCTGGCTACCCTTGAAAACAGGA
AGCTGAAGAGGGAACTACCCTTTTCATTCCGATCAATTAATACGAGAGAAAACCTGTATCTGGTGACAGAAACTCTGGAGACGGTAAAGG
AGGAAACCCTGAAAAGCGACCGGCAATATAAATTTTGGAGCCAGATCTCTCAGGGCCATCTCAGCTATAAACACAAGGGTTTTCTCCAGG
GATTTAAGGGCCAGCTCATACACACATACAACAAGAACAGCTCTGCGTGTGAGAACTCTGGTTACTTCCAGCAACTTGAGGGCAAAACCA
ATGTCATCCTGCTGGGAGACTCTATCGGGGACCTCACCATGGCCGATGGGGTTCCTGGTGTGCAGAACATTCTCAAAATTGGCTTCCTGA
ATGACAAGGTGGAGGAGCGGCGGGAGCGCTACATGGACTCCTATGACATCGTGCTGGAGAAGGACGAGACTCTGGATGTGGTCAACGGGC
TACTGCAGCACATCCTGTGCCAGGGGGTCCAGCTGGAGATGCAAGGCCCCTGAAGGCGCAGGCTCCAGCCCGGCCTGCAGGCCGTGGTGA
GGAGGGGCGCCTCCCCAGAGTCTGCTCCCCCGTGAACACAGAGCAGAGGCCAGGGTGGCCAGCAGTGGCTGGGTCCTTCCGCGCCCCTCC
GTCCTCCTTTCCCTGAGCACCTTCATCACCAGAGGCTTGAAGGAACCCCGCCATGTGGCAGGGCACAGGCACTGTTCCTGGTGAACCTTG
GACCACAGCATGTCAGTGCTCTAGGGATTGTCTACTCCAGGGATTTTCTTCAAAATTTTTAAACATGGGAAGTTCAAACAAATATAATGT
GTGAAACAGATCAAAATTTTTAAAATGAAAAAAAAGCTGCTCTGATTCAGGGGATGTGGGTGGGGGTAGAACCTGGACCTCTTGGCCCTG

>34988_34988_5_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000418519_NT5C3B_chr17_39983878_ENST00000269534_length(amino acids)=303AA_BP=192
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNV
DSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWS
QISQGHLSYKHKGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDS

--------------------------------------------------------------
>34988_34988_6_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000520542_NT5C3B_chr17_39983878_ENST00000269534_length(transcript)=1459nt_BP=683nt
ATTATTTTAGCTTCCTGAGATTCAGAGGCCAGGAACTGTGCAGAGATCTGTGGGGATTCTCACAACTTCCATTTCTGGTGAACAGCTGAG
GTCAGAGAGGAGGCGCAATGTTCAGCGTATTTGAGGAAATCACAAGAATTGTAGTTAAGGAGATGGATGCTGGAGGGGATATGATTGCCG
TTAGAAGCCTTGTTGATGCTGATAGATTCCGCTGCTTCCATCTGGTGGGGGAGAAGAGAACTTTCTTTGGATGCCGGCACTACACAACAG
GCCTCACCCTGATGGACATTCTGGACACAGATGGGGACAAGTGGTTAGATGAACTGGATTCTGGGCTCCAAGGTCAAAAGGCTGAGTTTC
AAATTCTGGATAATGTAGACTCAACGGGAGAGTTGATAGTGAGATTACCCAAAGAAATAACAATTTCAGGCAGTTTCCAGGGCTTCCACC
ATCAGAAAATCAAGATATCGGAGAACCGGATATCCCAGCAGTATCTGGCTACCCTTGAAAACAGGAAGCTGAAGAGGGAACTACCCTTTT
CATTCCGATCAATTAATACGAGAGAAAACCTGTATCTGGTGACAGAAACTCTGGAGACGGTAAAGGAGGAAACCCTGAAAAGCGACCGGC
AATATAAATTTTGGAGCCAGATCTCTCAGGGCCATCTCAGCTATAAACACAAGGGTTTTCTCCAGGGATTTAAGGGCCAGCTCATACACA
CATACAACAAGAACAGCTCTGCGTGTGAGAACTCTGGTTACTTCCAGCAACTTGAGGGCAAAACCAATGTCATCCTGCTGGGAGACTCTA
TCGGGGACCTCACCATGGCCGATGGGGTTCCTGGTGTGCAGAACATTCTCAAAATTGGCTTCCTGAATGACAAGGTGGAGGAGCGGCGGG
AGCGCTACATGGACTCCTATGACATCGTGCTGGAGAAGGACGAGACTCTGGATGTGGTCAACGGGCTACTGCAGCACATCCTGTGCCAGG
GGGTCCAGCTGGAGATGCAAGGCCCCTGAAGGCGCAGGCTCCAGCCCGGCCTGCAGGCCGTGGTGAGGAGGGGCGCCTCCCCAGAGTCTG
CTCCCCCGTGAACACAGAGCAGAGGCCAGGGTGGCCAGCAGTGGCTGGGTCCTTCCGCGCCCCTCCGTCCTCCTTTCCCTGAGCACCTTC
ATCACCAGAGGCTTGAAGGAACCCCGCCATGTGGCAGGGCACAGGCACTGTTCCTGGTGAACCTTGGACCACAGCATGTCAGTGCTCTAG
GGATTGTCTACTCCAGGGATTTTCTTCAAAATTTTTAAACATGGGAAGTTCAAACAAATATAATGTGTGAAACAGATCAAAATTTTTAAA
ATGAAAAAAAAGCTGCTCTGATTCAGGGGATGTGGGTGGGGGTAGAACCTGGACCTCTTGGCCCTGGGGGCACATGGGATGCTTCTAGGA

>34988_34988_6_GSDMB-NT5C3B_GSDMB_chr17_38066009_ENST00000520542_NT5C3B_chr17_39983878_ENST00000269534_length(amino acids)=303AA_BP=192
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNV
DSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWS
QISQGHLSYKHKGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GSDMB-NT5C3B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GSDMB-NT5C3B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GSDMB-NT5C3B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source