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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GSDMD-RANGAP1 (FusionGDB2 ID:34995)

Fusion Gene Summary for GSDMD-RANGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GSDMD-RANGAP1
Fusion gene ID: 34995
HgeneTgene
Gene symbol

GSDMD

RANGAP1

Gene ID

79792

5905

Gene namegasdermin DRan GTPase activating protein 1
SynonymsDF5L|DFNA5L|FKSG10|GSDMDC1Fug1|RANGAP|SD
Cytomap

8q24.3

22q13.2

Type of geneprotein-codingprotein-coding
Descriptiongasdermin-Dgasdermin domain containing 1gasdermin domain-containing protein 1ran GTPase-activating protein 1segregation distorter homologsegregation distortion
Modification date2020031320200313
UniProtAcc

P57764

.
Ensembl transtripts involved in fusion geneENST00000262580, ENST00000526406, 
ENST00000533063, 		ENST00000356244, 
ENST00000405486, ENST00000407260, 
ENST00000455915, 
Fusion gene scores* DoF score2 X 3 X 2=1211 X 10 X 7=770
# samples 312
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSDMD [Title/Abstract] AND RANGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGSDMD(144644228)-RANGAP1(41648995), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRANGAP1

GO:0046826

negative regulation of protein export from nucleus

16449645

TgeneRANGAP1

GO:0090630

activation of GTPase activity

16428860


check buttonFusion gene breakpoints across GSDMD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RANGAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A03F-01AGSDMDchr8

144644228

+RANGAP1chr22

41648995

-


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Fusion Gene ORF analysis for GSDMD-RANGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262580ENST00000356244GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000262580ENST00000405486GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000262580ENST00000407260GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000262580ENST00000455915GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000526406ENST00000356244GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000526406ENST00000405486GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000526406ENST00000407260GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000526406ENST00000455915GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000533063ENST00000356244GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000533063ENST00000405486GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000533063ENST00000407260GSDMDchr8

144644228

+RANGAP1chr22

41648995

-
In-frameENST00000533063ENST00000455915GSDMDchr8

144644228

+RANGAP1chr22

41648995

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000526406GSDMDchr8144644228+ENST00000405486RANGAP1chr2241648995-327517798081866352
ENST00000526406GSDMDchr8144644228+ENST00000356244RANGAP1chr2241648995-327517798081866352
ENST00000526406GSDMDchr8144644228+ENST00000455915RANGAP1chr2241648995-327117798081866352
ENST00000526406GSDMDchr8144644228+ENST00000407260RANGAP1chr2241648995-244317798081866352
ENST00000533063GSDMDchr8144644228+ENST00000405486RANGAP1chr2241648995-25791083161170384
ENST00000533063GSDMDchr8144644228+ENST00000356244RANGAP1chr2241648995-25791083161170384
ENST00000533063GSDMDchr8144644228+ENST00000455915RANGAP1chr2241648995-25751083161170384
ENST00000533063GSDMDchr8144644228+ENST00000407260RANGAP1chr2241648995-17471083161170384
ENST00000262580GSDMDchr8144644228+ENST00000405486RANGAP1chr2241648995-25411045741132352
ENST00000262580GSDMDchr8144644228+ENST00000356244RANGAP1chr2241648995-25411045741132352
ENST00000262580GSDMDchr8144644228+ENST00000455915RANGAP1chr2241648995-25371045741132352
ENST00000262580GSDMDchr8144644228+ENST00000407260RANGAP1chr2241648995-17091045741132352

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000526406ENST00000405486GSDMDchr8144644228+RANGAP1chr2241648995-0.212875380.7871247
ENST00000526406ENST00000356244GSDMDchr8144644228+RANGAP1chr2241648995-0.212875380.7871247
ENST00000526406ENST00000455915GSDMDchr8144644228+RANGAP1chr2241648995-0.209973380.79002655
ENST00000526406ENST00000407260GSDMDchr8144644228+RANGAP1chr2241648995-0.150363180.84963685
ENST00000533063ENST00000405486GSDMDchr8144644228+RANGAP1chr2241648995-0.256699120.74330086
ENST00000533063ENST00000356244GSDMDchr8144644228+RANGAP1chr2241648995-0.256699120.74330086
ENST00000533063ENST00000455915GSDMDchr8144644228+RANGAP1chr2241648995-0.251980660.7480194
ENST00000533063ENST00000407260GSDMDchr8144644228+RANGAP1chr2241648995-0.1197644840.88023555
ENST00000262580ENST00000405486GSDMDchr8144644228+RANGAP1chr2241648995-0.193812760.8061872
ENST00000262580ENST00000356244GSDMDchr8144644228+RANGAP1chr2241648995-0.193812760.8061872
ENST00000262580ENST00000455915GSDMDchr8144644228+RANGAP1chr2241648995-0.189519320.8104807
ENST00000262580ENST00000407260GSDMDchr8144644228+RANGAP1chr2241648995-0.088594170.9114058

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Fusion Genomic Features for GSDMD-RANGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GSDMD-RANGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:144644228/chr22:41648995)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSDMD

P57764

.
FUNCTION: [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). {ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216}.; FUNCTION: [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216, PubMed:29898893). Exhibits bactericidal activity (PubMed:27281216). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216). Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216). {ECO:0000250|UniProtKB:Q9D8T2, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:27418190, ECO:0000269|PubMed:28392147, ECO:0000269|PubMed:29898893, ECO:0000269|PubMed:32820063}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016523_526420588.0MotifNote=SUMO conjugation
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117523_526420588.0MotifNote=SUMO conjugation
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915523_526420588.0MotifNote=SUMO conjugation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016359_397420588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016359_399420588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117359_397420588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117359_399420588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915359_397420588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915359_399420588.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016111_134420588.0RepeatNote=LRR 2
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016207_230420588.0RepeatNote=LRR 3
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016235_258420588.0RepeatNote=LRR 4
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016292_319420588.0RepeatNote=LRR 5
TgeneRANGAP1chr8:144644228chr22:41648995ENST000003562441016320_343420588.0RepeatNote=LRR 6
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000356244101648_71420588.0RepeatNote=LRR 1
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117111_134420588.0RepeatNote=LRR 2
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117207_230420588.0RepeatNote=LRR 3
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117235_258420588.0RepeatNote=LRR 4
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117292_319420588.0RepeatNote=LRR 5
TgeneRANGAP1chr8:144644228chr22:41648995ENST000004054861117320_343420588.0RepeatNote=LRR 6
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000405486111748_71420588.0RepeatNote=LRR 1
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915111_134420588.0RepeatNote=LRR 2
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915207_230420588.0RepeatNote=LRR 3
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915235_258420588.0RepeatNote=LRR 4
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915292_319420588.0RepeatNote=LRR 5
TgeneRANGAP1chr8:144644228chr22:41648995ENST00000455915915320_343420588.0RepeatNote=LRR 6
TgeneRANGAP1chr8:144644228chr22:41648995ENST0000045591591548_71420588.0RepeatNote=LRR 1


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Fusion Gene Sequence for GSDMD-RANGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34995_34995_1_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000356244_length(transcript)=2541nt_BP=1045nt
GTTCCGGGAGGGCGTCCTGGGCGGGCCCTGCGTCAGGTTGCAGTTTCACTTTTAGCTCTGGGCACCTCCAGCTCCTGCTCGCCGGACGGC
TCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGA
GAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGG
TTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGG
AACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGAC
AGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGC
AGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGA
CTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGT
GCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGC
TGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCA
CGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGA
GGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGC
AGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGA
CACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGA
TGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCT
GCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCC
CAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCA
GACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAG
CCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCTGAGTATGTGTGTGG
GTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGTCTTCTGCTGGCCCAGCCCTGCTCTGTTGTGGGGAGTTG
GCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACCTGAGGGCGCTCTGCTGATCTCCGCCTGGGCCCTGATGG
CCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCCAGGGAGTTGCCCGCGTGCTGTCCTTCCCCTCTGTGTTG
TGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCTGGTCCTGCGGCAGCTGTCACCCCTACCATCCATACCAC
TGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGGGGGTCGGATCGTGGGGTTGTTGGCAGAGGGCAACCCTG
GGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCTGCTGGGACTGCGCTGGCCCCGGACCTAGTGGGCCTTCT
CCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTGACAACCCAAAGCTGTTCTCCAGTCTGGGGAGGGAGAGG
CAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCCTGGGGCAGGGGAGCGGTAGGGTCTGGACTGGGCAGATG
CTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGCTCTGTGTGTGTCTGGGCTGTGCCCGGGGGCTTCACAAA

>34995_34995_1_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000356244_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_2_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000405486_length(transcript)=2541nt_BP=1045nt
GTTCCGGGAGGGCGTCCTGGGCGGGCCCTGCGTCAGGTTGCAGTTTCACTTTTAGCTCTGGGCACCTCCAGCTCCTGCTCGCCGGACGGC
TCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGA
GAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGG
TTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGG
AACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGAC
AGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGC
AGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGA
CTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGT
GCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGC
TGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCA
CGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGA
GGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGC
AGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGA
CACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGA
TGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCT
GCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCC
CAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCA
GACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAG
CCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCTGAGTATGTGTGTGG
GTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGTCTTCTGCTGGCCCAGCCCTGCTCTGTTGTGGGGAGTTG
GCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACCTGAGGGCGCTCTGCTGATCTCCGCCTGGGCCCTGATGG
CCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCCAGGGAGTTGCCCGCGTGCTGTCCTTCCCCTCTGTGTTG
TGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCTGGTCCTGCGGCAGCTGTCACCCCTACCATCCATACCAC
TGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGGGGGTCGGATCGTGGGGTTGTTGGCAGAGGGCAACCCTG
GGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCTGCTGGGACTGCGCTGGCCCCGGACCTAGTGGGCCTTCT
CCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTGACAACCCAAAGCTGTTCTCCAGTCTGGGGAGGGAGAGG
CAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCCTGGGGCAGGGGAGCGGTAGGGTCTGGACTGGGCAGATG
CTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGCTCTGTGTGTGTCTGGGCTGTGCCCGGGGGCTTCACAAA

>34995_34995_2_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000405486_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_3_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000407260_length(transcript)=1709nt_BP=1045nt
GTTCCGGGAGGGCGTCCTGGGCGGGCCCTGCGTCAGGTTGCAGTTTCACTTTTAGCTCTGGGCACCTCCAGCTCCTGCTCGCCGGACGGC
TCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGA
GAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGG
TTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGG
AACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGAC
AGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGC
AGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGA
CTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGT
GCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGC
TGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCA
CGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGA
GGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGC
AGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGA
CACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGA
TGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCT
GCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCC
CAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCA
GACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAG

>34995_34995_3_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000407260_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_4_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000455915_length(transcript)=2537nt_BP=1045nt
GTTCCGGGAGGGCGTCCTGGGCGGGCCCTGCGTCAGGTTGCAGTTTCACTTTTAGCTCTGGGCACCTCCAGCTCCTGCTCGCCGGACGGC
TCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGA
GAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGG
TTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGG
AACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGAC
AGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGC
AGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGA
CTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGT
GCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGC
TGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCA
CGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGA
GGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGC
AGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGA
CACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGA
TGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCT
GCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCC
CAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCA
GACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAG
CCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCTGAGTATGTGTGTGG
GTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGTCTTCTGCTGGCCCAGCCCTGCTCTGTTGTGGGGAGTTG
GCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACCTGAGGGCGCTCTGCTGATCTCCGCCTGGGCCCTGATGG
CCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCCAGGGAGTTGCCCGCGTGCTGTCCTTCCCCTCTGTGTTG
TGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCTGGTCCTGCGGCAGCTGTCACCCCTACCATCCATACCAC
TGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGGGGGTCGGATCGTGGGGTTGTTGGCAGAGGGCAACCCTG
GGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCTGCTGGGACTGCGCTGGCCCCGGACCTAGTGGGCCTTCT
CCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTGACAACCCAAAGCTGTTCTCCAGTCTGGGGAGGGAGAGG
CAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCCTGGGGCAGGGGAGCGGTAGGGTCTGGACTGGGCAGATG
CTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGCTCTGTGTGTGTCTGGGCTGTGCCCGGGGGCTTCACAAA

>34995_34995_4_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000262580_RANGAP1_chr22_41648995_ENST00000455915_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_5_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000356244_length(transcript)=3275nt_BP=1779nt
CTTCCCGGCTCGGGGATTACCTCTCTGGCTGGTCCCCTCCTCCGTGCTCTGCGCGCCTCCACCCTAGCGCTTGTCTTGGCTCCTAGAACC
AGGGGCCTGGACGCTGCTCAGGGCAGAGGCGCCCCCTCTGAGGGGCTGGCCCCTCAGCCGCACTCCGAGACAGCCGCCCCCGGGACCGCC
CTTCCTTGGAGCCCCGCCGCCCGCCGCTCACTCTGCACACGCAGCAGAAGGGACGTGGTGTTCCCCAGGCTCTGGCCCCCCAGGACCTGC
GCGGATCTGGCCCAGGGCGCCTCGCCGACTTCCGTAAACTGGGCGGAGGGATGAACCCCGACCCAGGGGACGGAGGCGCTCGCCCTCTCG
CTGCAGGGTTCTGCCCTCAACACTTCTGGCCCCGCCTGTGAATGGGGGCCGGAGCGATGGGGCGGGGCCGGCCTCCCTCCCTCCTCCCAG
GCTGACCTCTGCCCTCCTTCGAGCACTTCCCGTTCGGGGTGATGATTGAAGAACTGAGTGTGGACAGAGCACCTGTCCTCGCCAGCGCCC
AGCTGGAAGCTGAGTTATTTGTGGCTGCAGCATTCCAACGCACACACCACCAGAAATCCCCTTCAGCATACTGGCCTCAGACCTACCAGG
GCAGAGACCTTGTCTTGTTTGCTGCTAGAACCCAGGATCGCTGGAAAATCACCTAGCAGCAGCCAGGTGCGGTGACTCACGCCTGTAATC
CCAGCACTTTGGAAGGCCAAGGCGGGTGGATAGCAAGGTCAAGAGATCGAGACCAGCCTGGCCAACATGCTCTGGGCACCTCCAGCTCCT
GCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGA
GCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCC
CTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGA
GCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCT
GGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGA
CCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAA
CGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCT
GCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATT
CCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGG
CCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGC
CAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCC
TCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATA
GCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGG
ATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTC
GTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAG
CAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGC
CACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGAT
GAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCT
GAGTATGTGTGTGGGTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGTCTTCTGCTGGCCCAGCCCTGCTCT
GTTGTGGGGAGTTGGCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACCTGAGGGCGCTCTGCTGATCTCCGC
CTGGGCCCTGATGGCCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCCAGGGAGTTGCCCGCGTGCTGTCCT
TCCCCTCTGTGTTGTGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCTGGTCCTGCGGCAGCTGTCACCCCT
ACCATCCATACCACTGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGGGGGTCGGATCGTGGGGTTGTTGGC
AGAGGGCAACCCTGGGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCTGCTGGGACTGCGCTGGCCCCGGAC
CTAGTGGGCCTTCTCCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTGACAACCCAAAGCTGTTCTCCAGTC
TGGGGAGGGAGAGGCAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCCTGGGGCAGGGGAGCGGTAGGGTCT
GGACTGGGCAGATGCTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGCTCTGTGTGTGTCTGGGCTGTGCCC

>34995_34995_5_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000356244_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_6_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000405486_length(transcript)=3275nt_BP=1779nt
CTTCCCGGCTCGGGGATTACCTCTCTGGCTGGTCCCCTCCTCCGTGCTCTGCGCGCCTCCACCCTAGCGCTTGTCTTGGCTCCTAGAACC
AGGGGCCTGGACGCTGCTCAGGGCAGAGGCGCCCCCTCTGAGGGGCTGGCCCCTCAGCCGCACTCCGAGACAGCCGCCCCCGGGACCGCC
CTTCCTTGGAGCCCCGCCGCCCGCCGCTCACTCTGCACACGCAGCAGAAGGGACGTGGTGTTCCCCAGGCTCTGGCCCCCCAGGACCTGC
GCGGATCTGGCCCAGGGCGCCTCGCCGACTTCCGTAAACTGGGCGGAGGGATGAACCCCGACCCAGGGGACGGAGGCGCTCGCCCTCTCG
CTGCAGGGTTCTGCCCTCAACACTTCTGGCCCCGCCTGTGAATGGGGGCCGGAGCGATGGGGCGGGGCCGGCCTCCCTCCCTCCTCCCAG
GCTGACCTCTGCCCTCCTTCGAGCACTTCCCGTTCGGGGTGATGATTGAAGAACTGAGTGTGGACAGAGCACCTGTCCTCGCCAGCGCCC
AGCTGGAAGCTGAGTTATTTGTGGCTGCAGCATTCCAACGCACACACCACCAGAAATCCCCTTCAGCATACTGGCCTCAGACCTACCAGG
GCAGAGACCTTGTCTTGTTTGCTGCTAGAACCCAGGATCGCTGGAAAATCACCTAGCAGCAGCCAGGTGCGGTGACTCACGCCTGTAATC
CCAGCACTTTGGAAGGCCAAGGCGGGTGGATAGCAAGGTCAAGAGATCGAGACCAGCCTGGCCAACATGCTCTGGGCACCTCCAGCTCCT
GCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGA
GCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCC
CTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGA
GCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCT
GGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGA
CCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAA
CGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCT
GCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATT
CCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGG
CCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGC
CAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCC
TCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATA
GCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGG
ATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTC
GTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAG
CAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGC
CACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGAT
GAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCT
GAGTATGTGTGTGGGTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGTCTTCTGCTGGCCCAGCCCTGCTCT
GTTGTGGGGAGTTGGCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACCTGAGGGCGCTCTGCTGATCTCCGC
CTGGGCCCTGATGGCCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCCAGGGAGTTGCCCGCGTGCTGTCCT
TCCCCTCTGTGTTGTGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCTGGTCCTGCGGCAGCTGTCACCCCT
ACCATCCATACCACTGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGGGGGTCGGATCGTGGGGTTGTTGGC
AGAGGGCAACCCTGGGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCTGCTGGGACTGCGCTGGCCCCGGAC
CTAGTGGGCCTTCTCCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTGACAACCCAAAGCTGTTCTCCAGTC
TGGGGAGGGAGAGGCAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCCTGGGGCAGGGGAGCGGTAGGGTCT
GGACTGGGCAGATGCTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGCTCTGTGTGTGTCTGGGCTGTGCCC

>34995_34995_6_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000405486_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_7_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000407260_length(transcript)=2443nt_BP=1779nt
CTTCCCGGCTCGGGGATTACCTCTCTGGCTGGTCCCCTCCTCCGTGCTCTGCGCGCCTCCACCCTAGCGCTTGTCTTGGCTCCTAGAACC
AGGGGCCTGGACGCTGCTCAGGGCAGAGGCGCCCCCTCTGAGGGGCTGGCCCCTCAGCCGCACTCCGAGACAGCCGCCCCCGGGACCGCC
CTTCCTTGGAGCCCCGCCGCCCGCCGCTCACTCTGCACACGCAGCAGAAGGGACGTGGTGTTCCCCAGGCTCTGGCCCCCCAGGACCTGC
GCGGATCTGGCCCAGGGCGCCTCGCCGACTTCCGTAAACTGGGCGGAGGGATGAACCCCGACCCAGGGGACGGAGGCGCTCGCCCTCTCG
CTGCAGGGTTCTGCCCTCAACACTTCTGGCCCCGCCTGTGAATGGGGGCCGGAGCGATGGGGCGGGGCCGGCCTCCCTCCCTCCTCCCAG
GCTGACCTCTGCCCTCCTTCGAGCACTTCCCGTTCGGGGTGATGATTGAAGAACTGAGTGTGGACAGAGCACCTGTCCTCGCCAGCGCCC
AGCTGGAAGCTGAGTTATTTGTGGCTGCAGCATTCCAACGCACACACCACCAGAAATCCCCTTCAGCATACTGGCCTCAGACCTACCAGG
GCAGAGACCTTGTCTTGTTTGCTGCTAGAACCCAGGATCGCTGGAAAATCACCTAGCAGCAGCCAGGTGCGGTGACTCACGCCTGTAATC
CCAGCACTTTGGAAGGCCAAGGCGGGTGGATAGCAAGGTCAAGAGATCGAGACCAGCCTGGCCAACATGCTCTGGGCACCTCCAGCTCCT
GCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGA
GCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCC
CTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGA
GCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCT
GGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGA
CCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAA
CGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCT
GCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATT
CCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGG
CCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGC
CAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCC
TCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATA
GCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGG
ATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTC
GTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAG
CAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGC
CACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGAT
GAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCT

>34995_34995_7_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000407260_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_8_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000455915_length(transcript)=3271nt_BP=1779nt
CTTCCCGGCTCGGGGATTACCTCTCTGGCTGGTCCCCTCCTCCGTGCTCTGCGCGCCTCCACCCTAGCGCTTGTCTTGGCTCCTAGAACC
AGGGGCCTGGACGCTGCTCAGGGCAGAGGCGCCCCCTCTGAGGGGCTGGCCCCTCAGCCGCACTCCGAGACAGCCGCCCCCGGGACCGCC
CTTCCTTGGAGCCCCGCCGCCCGCCGCTCACTCTGCACACGCAGCAGAAGGGACGTGGTGTTCCCCAGGCTCTGGCCCCCCAGGACCTGC
GCGGATCTGGCCCAGGGCGCCTCGCCGACTTCCGTAAACTGGGCGGAGGGATGAACCCCGACCCAGGGGACGGAGGCGCTCGCCCTCTCG
CTGCAGGGTTCTGCCCTCAACACTTCTGGCCCCGCCTGTGAATGGGGGCCGGAGCGATGGGGCGGGGCCGGCCTCCCTCCCTCCTCCCAG
GCTGACCTCTGCCCTCCTTCGAGCACTTCCCGTTCGGGGTGATGATTGAAGAACTGAGTGTGGACAGAGCACCTGTCCTCGCCAGCGCCC
AGCTGGAAGCTGAGTTATTTGTGGCTGCAGCATTCCAACGCACACACCACCAGAAATCCCCTTCAGCATACTGGCCTCAGACCTACCAGG
GCAGAGACCTTGTCTTGTTTGCTGCTAGAACCCAGGATCGCTGGAAAATCACCTAGCAGCAGCCAGGTGCGGTGACTCACGCCTGTAATC
CCAGCACTTTGGAAGGCCAAGGCGGGTGGATAGCAAGGTCAAGAGATCGAGACCAGCCTGGCCAACATGCTCTGGGCACCTCCAGCTCCT
GCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTCACGGAGCATGGGGTCGGCCTTTGA
GCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCTGCAGAGCTCCACTGGCTTCCAGCC
CTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAACCTGTCTATCAAGGACATCCTGGA
GCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGGGCAGATACAGGGCAGCGTGGAGCT
GGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAATGAATGTGTACTCGCTGAGTGTGGA
CCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCAGCAGCTGCGCAGCCGCGGGGACAA
CGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCGGGAGGGCTCGGGCCGGTTTTCCCT
GCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCATCCCCTCAGGCAGCACCCTCGCATT
CCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAGGACCTTCCAGCCACCCGCGACAGG
CCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTGCCTCCACAACTTCCTGACAGGTGC
CAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAGGCGGAGCCAGCTCCCGTGCTGTCC
TCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTAGGGCCCAAGAGCTCCGTGCTGATA
GCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTGTTCAAGGACGAAGCTACTGTGAGG
ATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCCAACACCTTCCTCACCAGGCTGCTC
GTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTGATGGCGCTGAACCACATGGTGCAG
CAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCCCTGGAATCCTGCTCCTTCGCCCGC
CACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACCAGTGAGCTGGGGAGGGACTCGGAT
GAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTGTCCCATGTGTCCTGTCAGTCCCCT
GAGTATGTGTGTGGGTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGTCTTCTGCTGGCCCAGCCCTGCTCT
GTTGTGGGGAGTTGGCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACCTGAGGGCGCTCTGCTGATCTCCGC
CTGGGCCCTGATGGCCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCCAGGGAGTTGCCCGCGTGCTGTCCT
TCCCCTCTGTGTTGTGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCTGGTCCTGCGGCAGCTGTCACCCCT
ACCATCCATACCACTGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGGGGGTCGGATCGTGGGGTTGTTGGC
AGAGGGCAACCCTGGGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCTGCTGGGACTGCGCTGGCCCCGGAC
CTAGTGGGCCTTCTCCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTGACAACCCAAAGCTGTTCTCCAGTC
TGGGGAGGGAGAGGCAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCCTGGGGCAGGGGAGCGGTAGGGTCT
GGACTGGGCAGATGCTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGCTCTGTGTGTGTCTGGGCTGTGCCC

>34995_34995_8_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000526406_RANGAP1_chr22_41648995_ENST00000455915_length(amino acids)=352AA_BP=323
MLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDIL
EPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGD
NVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPAT

--------------------------------------------------------------
>34995_34995_9_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000356244_length(transcript)=2579nt_BP=1083nt
GAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACAATGGCATGATCTCGGCTCACTGCAACCTACACCTCCCAGGTTCAAGCGATTC
TCTTGCCTCAGCCTCCCAGCTCCTGCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTC
ACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCT
GCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAA
CCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGG
GCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAAT
GAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCA
GCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCG
GGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCAT
CCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAG
GACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTG
CCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAG
GCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTA
GGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTG
TTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCC
AACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTG
ATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCC
CTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACC
AGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTG
TCCCATGTGTCCTGTCAGTCCCCTGAGTATGTGTGTGGGTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGT
CTTCTGCTGGCCCAGCCCTGCTCTGTTGTGGGGAGTTGGCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACC
TGAGGGCGCTCTGCTGATCTCCGCCTGGGCCCTGATGGCCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCC
AGGGAGTTGCCCGCGTGCTGTCCTTCCCCTCTGTGTTGTGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCT
GGTCCTGCGGCAGCTGTCACCCCTACCATCCATACCACTGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGG
GGGTCGGATCGTGGGGTTGTTGGCAGAGGGCAACCCTGGGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCT
GCTGGGACTGCGCTGGCCCCGGACCTAGTGGGCCTTCTCCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTG
ACAACCCAAAGCTGTTCTCCAGTCTGGGGAGGGAGAGGCAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCC
TGGGGCAGGGGAGCGGTAGGGTCTGGACTGGGCAGATGCTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGC

>34995_34995_9_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000356244_length(amino acids)=384AA_BP=2
MSPRLEYNGMISAHCNLHLPGSSDSLASASQLLLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTG
FQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSL
SVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGST
LAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTGASCCWRAWRGCCGTSWPCEPWRRRSQLP

--------------------------------------------------------------
>34995_34995_10_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000405486_length(transcript)=2579nt_BP=1083nt
GAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACAATGGCATGATCTCGGCTCACTGCAACCTACACCTCCCAGGTTCAAGCGATTC
TCTTGCCTCAGCCTCCCAGCTCCTGCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTC
ACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCT
GCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAA
CCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGG
GCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAAT
GAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCA
GCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCG
GGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCAT
CCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAG
GACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTG
CCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAG
GCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTA
GGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTG
TTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCC
AACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTG
ATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCC
CTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACC
AGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTG
TCCCATGTGTCCTGTCAGTCCCCTGAGTATGTGTGTGGGTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGT
CTTCTGCTGGCCCAGCCCTGCTCTGTTGTGGGGAGTTGGCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACC
TGAGGGCGCTCTGCTGATCTCCGCCTGGGCCCTGATGGCCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCC
AGGGAGTTGCCCGCGTGCTGTCCTTCCCCTCTGTGTTGTGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCT
GGTCCTGCGGCAGCTGTCACCCCTACCATCCATACCACTGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGG
GGGTCGGATCGTGGGGTTGTTGGCAGAGGGCAACCCTGGGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCT
GCTGGGACTGCGCTGGCCCCGGACCTAGTGGGCCTTCTCCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTG
ACAACCCAAAGCTGTTCTCCAGTCTGGGGAGGGAGAGGCAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCC
TGGGGCAGGGGAGCGGTAGGGTCTGGACTGGGCAGATGCTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGC

>34995_34995_10_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000405486_length(amino acids)=384AA_BP=2
MSPRLEYNGMISAHCNLHLPGSSDSLASASQLLLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTG
FQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSL
SVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGST
LAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTGASCCWRAWRGCCGTSWPCEPWRRRSQLP

--------------------------------------------------------------
>34995_34995_11_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000407260_length(transcript)=1747nt_BP=1083nt
GAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACAATGGCATGATCTCGGCTCACTGCAACCTACACCTCCCAGGTTCAAGCGATTC
TCTTGCCTCAGCCTCCCAGCTCCTGCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTC
ACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCT
GCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAA
CCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGG
GCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAAT
GAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCA
GCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCG
GGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCAT
CCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAG
GACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTG
CCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAG
GCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTA
GGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTG
TTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCC
AACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTG
ATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCC
CTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACC
AGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTG

>34995_34995_11_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000407260_length(amino acids)=384AA_BP=2
MSPRLEYNGMISAHCNLHLPGSSDSLASASQLLLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTG
FQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSL
SVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGST
LAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTGASCCWRAWRGCCGTSWPCEPWRRRSQLP

--------------------------------------------------------------
>34995_34995_12_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000455915_length(transcript)=2575nt_BP=1083nt
GAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTACAATGGCATGATCTCGGCTCACTGCAACCTACACCTCCCAGGTTCAAGCGATTC
TCTTGCCTCAGCCTCCCAGCTCCTGCTCGCCGGACGGCTCCCAGGGAGAGCAGACGCGCCAGACGCGCCACCCTCGGGGCGCCGACGGTC
ACGGAGCATGGGGTCGGCCTTTGAGCGGGTAGTCCGGAGAGTGGTCCAGGAGCTGGACCATGGTGGGGAGTTCATCCCTGTGACCAGCCT
GCAGAGCTCCACTGGCTTCCAGCCCTACTGCCTGGTGGTTAGGAAGCCCTCAAGCTCATGGTTCTGGAAACCCCGTTATAAGTGTGTCAA
CCTGTCTATCAAGGACATCCTGGAGCCGGATGCCGCGGAACCAGACGTGCAGCGTGGCAGGAGCTTCCACTTCTACGATGCCATGGATGG
GCAGATACAGGGCAGCGTGGAGCTGGCAGCCCCAGGACAGGCAAAGATCGCAGGCGGGGCCGCGGTGTCTGACAGCTCCAGCACCTCAAT
GAATGTGTACTCGCTGAGTGTGGACCCTAACACCTGGCAGACTCTGCTCCATGAGAGGCACCTGCGGCAGCCAGAACACAAAGTCCTGCA
GCAGCTGCGCAGCCGCGGGGACAACGTGTACGTGGTGACTGAGGTGCTGCAGACACAGAAGGAGGTGGAAGTCACGCGCACCCACAAGCG
GGAGGGCTCGGGCCGGTTTTCCCTGCCCGGAGCCACGTGCTTGCAGGGTGAGGGCCAGGGCCATCTGAGCCAGAAGAAGACGGTCACCAT
CCCCTCAGGCAGCACCCTCGCATTCCGGGTGGCCCAGCTGGTTATTGACTCTGACTTGGACGTCCTTCTCTTCCCGGATAAGAAGCAGAG
GACCTTCCAGCCACCCGCGACAGGCCACAAGCGTTCCACGAGCGAAGGCGCCTGGCCACAGCTGCCCTCTGGCCTCTCCATGATGAGGTG
CCTCCACAACTTCCTGACAGGTGCCAGCTGCTGCTGGAGGGCCTGGAGGGGGTGCTGCGGGACCAGCTGGCCCTGCGAGCCTTGGAGGAG
GCGGAGCCAGCTCCCGTGCTGTCCTCCCCACCTCCTGCAGACGTCTCCACCTTCCTGGCTTTTCCCTCTCCAGAGAAGCTGCTGCGCCTA
GGGCCCAAGAGCTCCGTGCTGATAGCCCAGCAGACTGACACGTCTGACCCCGAGAAGGTGGTCTCTGCCTTCCTAAAGGTGTCATCTGTG
TTCAAGGACGAAGCTACTGTGAGGATGGCAGTGCAGGATGCAGTAGATGCCCTGATGCAGAAGGCTTTCAACTCCTCGTCCTTCAACTCC
AACACCTTCCTCACCAGGCTGCTCGTGCACATGGGTCTGCTCAAGAGTGAAGACAAGGTCAAGGCCATTGCCAACCTGTACGGCCCCCTG
ATGGCGCTGAACCACATGGTGCAGCAGGACTATTTCCCCAAGGCCCTTGCACCCCTGCTGCTGGCGTTCGTGACCAAGCCCAACAGCGCC
CTGGAATCCTGCTCCTTCGCCCGCCACAGTCTGCTGCAGACGCTGTACAAGGTCTAGACTCAAAGCCTCTCCCATCCCTTGGCCTGGACC
AGTGAGCTGGGGAGGGACTCGGATGAACTGAGGCGCAGCCTACGCCATTGCCTTGGACAGGACTCTGGCCACAGGCAGGGCGGGTCTGTG
TCCCATGTGTCCTGTCAGTCCCCTGAGTATGTGTGTGGGTGTGGCGCATGTGCAGGTCTGTGCCTCCTGTCGGGATTTGGGTTTTAACGT
CTTCTGCTGGCCCAGCCCTGCTCTGTTGTGGGGAGTTGGCCCCCAGGGGAAAGGGCTGTGAGCTGCTCCGCCATTAAACTCACCTCCACC
TGAGGGCGCTCTGCTGATCTCCGCCTGGGCCCTGATGGCCGTCCCCACCCACCTGCCTTCCGGCCCGGCTCCCTGGCGGAGCCAGAACCC
AGGGAGTTGCCCGCGTGCTGTCCTTCCCCTCTGTGTTGTGATTGGGTTGTTTCCTGCCCTGCCTGGGGCTGCTTCTCGTCACCAAGCCCT
GGTCCTGCGGCAGCTGTCACCCCTACCATCCATACCACTGTGCTGACCGCTCAGCCTGAAGAGCAGAGAATGCCATGGGTGGGACTGTGG
GGGTCGGATCGTGGGGTTGTTGGCAGAGGGCAACCCTGGGCCCCACACCGTGTGGACAGGCAGACACCAGATTGTCCAGGAGCAGGAGCT
GCTGGGACTGCGCTGGCCCCGGACCTAGTGGGCCTTCTCCTGGCTGCTGAGATGTCGTCTGTGACTGGCCTGGCTGGAGGGGGAGTGTTG
ACAACCCAAAGCTGTTCTCCAGTCTGGGGAGGGAGAGGCAGGGTCCCCAATGTCCGAGCTGCATCTGGACGCTGCTCTTAAAGGACCTCC
TGGGGCAGGGGAGCGGTAGGGTCTGGACTGGGCAGATGCTGTATGACCTCCCTGAGCACCCGTGACTGCCCCATGCTTTCCCCTTTGTGC

>34995_34995_12_GSDMD-RANGAP1_GSDMD_chr8_144644228_ENST00000533063_RANGAP1_chr22_41648995_ENST00000455915_length(amino acids)=384AA_BP=2
MSPRLEYNGMISAHCNLHLPGSSDSLASASQLLLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTG
FQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSL
SVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGST
LAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTGASCCWRAWRGCCGTSWPCEPWRRRSQLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GSDMD-RANGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GSDMD-RANGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GSDMD-RANGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource