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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GSE1-CDH13 (FusionGDB2 ID:34999)

Fusion Gene Summary for GSE1-CDH13

check button Fusion gene summary
Fusion gene informationFusion gene name: GSE1-CDH13
Fusion gene ID: 34999
HgeneTgene
Gene symbol

GSE1

CDH13

Gene ID

23199

1012

Gene nameGse1 coiled-coil proteincadherin 13
SynonymsCRHSP24|KIAA0182CDHH|P105
Cytomap

16q24.1

16q23.3

Type of geneprotein-codingprotein-coding
Descriptiongenetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homologcadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherin
Modification date2020032720200315
UniProtAcc

Q14687

P55290

Ensembl transtripts involved in fusion geneENST00000253458, ENST00000393243, 
ENST00000405402, ENST00000471070, 
ENST00000569454, ENST00000428848, 
ENST00000431540, ENST00000446376, 
ENST00000565636, ENST00000567445, 
ENST00000268613, ENST00000566620, 
Fusion gene scores* DoF score23 X 18 X 8=331215 X 16 X 5=1200
# samples 2316
** MAII scorelog2(23/3312*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1200*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSE1 [Title/Abstract] AND CDH13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGSE1(85647004)-CDH13(83520082), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDH13

GO:0002040

sprouting angiogenesis

16873731

TgeneCDH13

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

10601632

TgeneCDH13

GO:0007162

negative regulation of cell adhesion

14729458

TgeneCDH13

GO:0008285

negative regulation of cell proliferation

10737605

TgeneCDH13

GO:0016339

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

10601632

TgeneCDH13

GO:0030032

lamellipodium assembly

15703273

TgeneCDH13

GO:0030335

positive regulation of cell migration

14729458

TgeneCDH13

GO:0043542

endothelial cell migration

14729458

TgeneCDH13

GO:0043616

keratinocyte proliferation

15816843

TgeneCDH13

GO:0050850

positive regulation of calcium-mediated signaling

16013438

TgeneCDH13

GO:0050927

positive regulation of positive chemotaxis

16013438

TgeneCDH13

GO:0055096

low-density lipoprotein particle mediated signaling

16013438


check buttonFusion gene breakpoints across GSE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8590-01AGSE1chr16

85647004

+CDH13chr16

83520082

+


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Fusion Gene ORF analysis for GSE1-CDH13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000253458ENST00000569454GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-3UTRENST00000393243ENST00000569454GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000253458ENST00000428848GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000253458ENST00000431540GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000253458ENST00000446376GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000253458ENST00000565636GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000253458ENST00000567445GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000393243ENST00000428848GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000393243ENST00000431540GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000393243ENST00000446376GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000393243ENST00000565636GSE1chr16

85647004

+CDH13chr16

83520082

+
5CDS-intronENST00000393243ENST00000567445GSE1chr16

85647004

+CDH13chr16

83520082

+
In-frameENST00000253458ENST00000268613GSE1chr16

85647004

+CDH13chr16

83520082

+
In-frameENST00000253458ENST00000566620GSE1chr16

85647004

+CDH13chr16

83520082

+
In-frameENST00000393243ENST00000268613GSE1chr16

85647004

+CDH13chr16

83520082

+
In-frameENST00000393243ENST00000566620GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-3CDSENST00000405402ENST00000268613GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-3CDSENST00000405402ENST00000566620GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-3CDSENST00000471070ENST00000268613GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-3CDSENST00000471070ENST00000566620GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-3UTRENST00000405402ENST00000569454GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-3UTRENST00000471070ENST00000569454GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000405402ENST00000428848GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000405402ENST00000431540GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000405402ENST00000446376GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000405402ENST00000565636GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000405402ENST00000567445GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000471070ENST00000428848GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000471070ENST00000431540GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000471070ENST00000446376GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000471070ENST00000565636GSE1chr16

85647004

+CDH13chr16

83520082

+
intron-intronENST00000471070ENST00000567445GSE1chr16

85647004

+CDH13chr16

83520082

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253458GSE1chr1685647004+ENST00000566620CDH13chr1683520082+31131831611543460
ENST00000253458GSE1chr1685647004+ENST00000268613CDH13chr1683520082+18901831611543460
ENST00000393243GSE1chr1685647004+ENST00000566620CDH13chr1683520082+297747251407460
ENST00000393243GSE1chr1685647004+ENST00000268613CDH13chr1683520082+175447251407460

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253458ENST00000566620GSE1chr1685647004+CDH13chr1683520082+0.0004934350.9995066
ENST00000253458ENST00000268613GSE1chr1685647004+CDH13chr1683520082+0.0009784230.99902153
ENST00000393243ENST00000566620GSE1chr1685647004+CDH13chr1683520082+0.0004095160.99959046
ENST00000393243ENST00000268613GSE1chr1685647004+CDH13chr1683520082+0.0007381250.9992619

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Fusion Genomic Features for GSE1-CDH13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GSE1chr1685647004+CDH13chr1683520081+3.77E-060.9999962
GSE1chr1685647004+CDH13chr1683520081+3.77E-060.9999962

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GSE1-CDH13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:85647004/chr16:83520082)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSE1

Q14687

CDH13

P55290

FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDH13chr16:85647004chr16:83520082ENST00000268613615364_477307761.0DomainCadherin 3
TgeneCDH13chr16:85647004chr16:83520082ENST00000268613615478_585307761.0DomainCadherin 4
TgeneCDH13chr16:85647004chr16:83520082ENST00000268613615584_694307761.0DomainCadherin 5
TgeneCDH13chr16:85647004chr16:83520082ENST0000043154005139_2450191.0DomainCadherin 1
TgeneCDH13chr16:85647004chr16:83520082ENST0000043154005246_3630191.0DomainCadherin 2
TgeneCDH13chr16:85647004chr16:83520082ENST0000043154005364_4770191.0DomainCadherin 3
TgeneCDH13chr16:85647004chr16:83520082ENST0000043154005478_5850191.0DomainCadherin 4
TgeneCDH13chr16:85647004chr16:83520082ENST0000043154005584_6940191.0DomainCadherin 5
TgeneCDH13chr16:85647004chr16:83520082ENST0000044637605139_2450176.0DomainCadherin 1
TgeneCDH13chr16:85647004chr16:83520082ENST0000044637605246_3630176.0DomainCadherin 2
TgeneCDH13chr16:85647004chr16:83520082ENST0000044637605364_4770176.0DomainCadherin 3
TgeneCDH13chr16:85647004chr16:83520082ENST0000044637605478_5850176.0DomainCadherin 4
TgeneCDH13chr16:85647004chr16:83520082ENST0000044637605584_6940176.0DomainCadherin 5
TgeneCDH13chr16:85647004chr16:83520082ENST0000056563606139_2450171.33333333333334DomainCadherin 1
TgeneCDH13chr16:85647004chr16:83520082ENST0000056563606246_3630171.33333333333334DomainCadherin 2
TgeneCDH13chr16:85647004chr16:83520082ENST0000056563606364_4770171.33333333333334DomainCadherin 3
TgeneCDH13chr16:85647004chr16:83520082ENST0000056563606478_5850171.33333333333334DomainCadherin 4
TgeneCDH13chr16:85647004chr16:83520082ENST0000056563606584_6940171.33333333333334DomainCadherin 5
TgeneCDH13chr16:85647004chr16:83520082ENST00000566620514364_477260714.0DomainCadherin 3
TgeneCDH13chr16:85647004chr16:83520082ENST00000566620514478_585260714.0DomainCadherin 4
TgeneCDH13chr16:85647004chr16:83520082ENST00000566620514584_694260714.0DomainCadherin 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSE1chr16:85647004chr16:83520082ENST00000253458+1161127_120121218.0Coiled coilOntology_term=ECO:0000255
HgeneGSE1chr16:85647004chr16:83520082ENST00000253458+116321_40321218.0Coiled coilOntology_term=ECO:0000255
HgeneGSE1chr16:85647004chr16:83520082ENST00000393243+1151127_120121145.0Coiled coilOntology_term=ECO:0000255
HgeneGSE1chr16:85647004chr16:83520082ENST00000393243+115321_40321145.0Coiled coilOntology_term=ECO:0000255
HgeneGSE1chr16:85647004chr16:83520082ENST00000405402+1151127_120101114.0Coiled coilOntology_term=ECO:0000255
HgeneGSE1chr16:85647004chr16:83520082ENST00000405402+115321_40301114.0Coiled coilOntology_term=ECO:0000255
HgeneGSE1chr16:85647004chr16:83520082ENST00000253458+1161102_110721218.0Compositional biasNote=Poly-Glu
HgeneGSE1chr16:85647004chr16:83520082ENST00000253458+116532_72221218.0Compositional biasNote=Pro-rich
HgeneGSE1chr16:85647004chr16:83520082ENST00000253458+116745_74821218.0Compositional biasNote=Poly-Arg
HgeneGSE1chr16:85647004chr16:83520082ENST00000393243+1151102_110721145.0Compositional biasNote=Poly-Glu
HgeneGSE1chr16:85647004chr16:83520082ENST00000393243+115532_72221145.0Compositional biasNote=Pro-rich
HgeneGSE1chr16:85647004chr16:83520082ENST00000393243+115745_74821145.0Compositional biasNote=Poly-Arg
HgeneGSE1chr16:85647004chr16:83520082ENST00000405402+1151102_110701114.0Compositional biasNote=Poly-Glu
HgeneGSE1chr16:85647004chr16:83520082ENST00000405402+115532_72201114.0Compositional biasNote=Pro-rich
HgeneGSE1chr16:85647004chr16:83520082ENST00000405402+115745_74801114.0Compositional biasNote=Poly-Arg
TgeneCDH13chr16:85647004chr16:83520082ENST00000268613615139_245307761.0DomainCadherin 1
TgeneCDH13chr16:85647004chr16:83520082ENST00000268613615246_363307761.0DomainCadherin 2
TgeneCDH13chr16:85647004chr16:83520082ENST00000566620514139_245260714.0DomainCadherin 1
TgeneCDH13chr16:85647004chr16:83520082ENST00000566620514246_363260714.0DomainCadherin 2


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Fusion Gene Sequence for GSE1-CDH13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34999_34999_1_GSE1-CDH13_GSE1_chr16_85647004_ENST00000253458_CDH13_chr16_83520082_ENST00000268613_length(transcript)=1890nt_BP=183nt
TCCTCGGCGGCGACAGCAGCAGGTGTTTCTTGGCCGGGGCCCCGGAAGCTCCACCTCCCCAGCGGGCCCGAGCTGCCGCCGCCGAGCAGC
CCCGGGTGAGATAAGCAGTTTAGACAAACACTGGGCGACGGTGGCTCCAGCATGTATCAGCCGAGGTGGAGCTGCGGGGCCCTGGCATGA
AAGGCACCACAGTGATGCGGATGACAGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGA
CGCCTGACAAGCCATCTCCCAACATGTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAG
AGACTCTGGAAAATCCCAAGTATGAACTGATCATCGAGGCTCAAGATATGGCTGGACTGGATGTTGGATTAACAGGCACGGCCACAGCCA
CGATCATGATCGATGACAAAAATGATCACTCACCAAAATTCACCAAGAAAGAGTTTCAAGCCACAGTCGAGGAAGGAGCTGTGGGAGTTA
TTGTCAATTTGACAGTTGAAGATAAGGATGACCCCACCACAGGTGCATGGAGGGCTGCCTACACCATCATCAACGGAAACCCCGGGCAGA
GCTTTGAAATCCACACCAACCCTCAAACCAACGAAGGGATGCTTTCTGTTGTCAAACCATTGGACTATGAAATTTCTGCCTTCCACACCC
TGCTGATCAAAGTGGAAAATGAAGACCCACTCGTACCCGACGTCTCCTACGGCCCCAGCTCCACAGCCACCGTCCACATCACTGTCCTGG
ATGTCAACGAGGGCCCAGTCTTCTACCCAGACCCCATGATGGTGACCAGGCAGGAGGACCTCTCTGTGGGCAGCGTGCTGCTGACAGTGA
ATGCCACGGACCCCGACTCCCTGCAGCATCAAACCATCAGGTATTCTGTTTACAAGGACCCAGCAGGTTGGCTGAATATTAACCCCATCA
ATGGGACTGTTGACACCACAGCTGTGCTGGACCGTGAGTCCCCATTTGTCGACAACAGCGTGTACACTGCTCTCTTCCTGGCAATTGACA
GTGGCAACCCTCCCGCTACGGGCACTGGGACTTTGCTGATAACCCTGGAGGACGTGAATGACAATGCCCCGTTCATTTACCCCACAGTAG
CTGAAGTCTGTGATGATGCCAAAAACCTCAGTGTAGTCATTTTGGGAGCATCAGATAAGGATCTTCACCCGAATACAGATCCTTTCAAAT
TTGAAATCCACAAACAAGCTGTTCCTGATAAAGTCTGGAAGATCTCCAAGATCAACAATACACACGCCCTGGTAAGCCTTCTTCAAAATC
TGAACAAAGCAAACTACAACCTGCCCATCATGGTGACAGATTCAGGGAAACCACCCATGACGAATATCACAGATCTCAGGGTACAAGTGT
GCTCCTGCAGGAATTCCAAAGTGGACTGCAACGCGGCAGGGGCCCTGCGCTTCAGCCTGCCCTCAGTCCTGCTCCTCAGCCTCTTCAGCT
TAGCTTGTCTGTGAGAACTCCTGACGTCTGAAGCTTGACTCCCAAGTTTCCATAGCAACAGGAAAAAAAAAAATCTATCCAAATCTGAAG
ATTGCGGTTTACAGCTATCGAACTTCACAACTAGGCCTCAATTGTTCCGGTTTTTTATTTTCTTTACAATTTCACTTAGTCTGTACTTCA
TCATTTTGACAGCATCTTCCTCCCTCCTTTAATTAATGGAATCTTCTGAATTTTCCCTGAATGTTTAAAGATCATGACATATGACTTGAT
CTTCTGGGAGCAGGAACAATGACTACTTTTTCTGGTGTGTTAACATGTCGCTAGCCAGTGCTCCAGGCACCCAGCTTTGTCTGTGGGTTA

>34999_34999_1_GSE1-CDH13_GSE1_chr16_85647004_ENST00000253458_CDH13_chr16_83520082_ENST00000268613_length(amino acids)=460AA_BP=7
MRGPGMKGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGL
TGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYE
ISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGW
LNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHP
NTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVL

--------------------------------------------------------------
>34999_34999_2_GSE1-CDH13_GSE1_chr16_85647004_ENST00000253458_CDH13_chr16_83520082_ENST00000566620_length(transcript)=3113nt_BP=183nt
TCCTCGGCGGCGACAGCAGCAGGTGTTTCTTGGCCGGGGCCCCGGAAGCTCCACCTCCCCAGCGGGCCCGAGCTGCCGCCGCCGAGCAGC
CCCGGGTGAGATAAGCAGTTTAGACAAACACTGGGCGACGGTGGCTCCAGCATGTATCAGCCGAGGTGGAGCTGCGGGGCCCTGGCATGA
AAGGCACCACAGTGATGCGGATGACAGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGA
CGCCTGACAAGCCATCTCCCAACATGTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAG
AGACTCTGGAAAATCCCAAGTATGAACTGATCATCGAGGCTCAAGATATGGCTGGACTGGATGTTGGATTAACAGGCACGGCCACAGCCA
CGATCATGATCGATGACAAAAATGATCACTCACCAAAATTCACCAAGAAAGAGTTTCAAGCCACAGTCGAGGAAGGAGCTGTGGGAGTTA
TTGTCAATTTGACAGTTGAAGATAAGGATGACCCCACCACAGGTGCATGGAGGGCTGCCTACACCATCATCAACGGAAACCCCGGGCAGA
GCTTTGAAATCCACACCAACCCTCAAACCAACGAAGGGATGCTTTCTGTTGTCAAACCATTGGACTATGAAATTTCTGCCTTCCACACCC
TGCTGATCAAAGTGGAAAATGAAGACCCACTCGTACCCGACGTCTCCTACGGCCCCAGCTCCACAGCCACCGTCCACATCACTGTCCTGG
ATGTCAACGAGGGCCCAGTCTTCTACCCAGACCCCATGATGGTGACCAGGCAGGAGGACCTCTCTGTGGGCAGCGTGCTGCTGACAGTGA
ATGCCACGGACCCCGACTCCCTGCAGCATCAAACCATCAGGTATTCTGTTTACAAGGACCCAGCAGGTTGGCTGAATATTAACCCCATCA
ATGGGACTGTTGACACCACAGCTGTGCTGGACCGTGAGTCCCCATTTGTCGACAACAGCGTGTACACTGCTCTCTTCCTGGCAATTGACA
GTGGCAACCCTCCCGCTACGGGCACTGGGACTTTGCTGATAACCCTGGAGGACGTGAATGACAATGCCCCGTTCATTTACCCCACAGTAG
CTGAAGTCTGTGATGATGCCAAAAACCTCAGTGTAGTCATTTTGGGAGCATCAGATAAGGATCTTCACCCGAATACAGATCCTTTCAAAT
TTGAAATCCACAAACAAGCTGTTCCTGATAAAGTCTGGAAGATCTCCAAGATCAACAATACACACGCCCTGGTAAGCCTTCTTCAAAATC
TGAACAAAGCAAACTACAACCTGCCCATCATGGTGACAGATTCAGGGAAACCACCCATGACGAATATCACAGATCTCAGGGTACAAGTGT
GCTCCTGCAGGAATTCCAAAGTGGACTGCAACGCGGCAGGGGCCCTGCGCTTCAGCCTGCCCTCAGTCCTGCTCCTCAGCCTCTTCAGCT
TAGCTTGTCTGTGAGAACTCCTGACGTCTGAAGCTTGACTCCCAAGTTTCCATAGCAACAGGAAAAAAAAAAATCTATCCAAATCTGAAG
ATTGCGGTTTACAGCTATCGAACTTCACAACTAGGCCTCAATTGTTCCGGTTTTTTATTTTCTTTACAATTTCACTTAGTCTGTACTTCA
TCATTTTGACAGCATCTTCCTCCCTCCTTTAATTAATGGAATCTTCTGAATTTTCCCTGAATGTTTAAAGATCATGACATATGACTTGAT
CTTCTGGGAGCAGGAACAATGACTACTTTTTCTGGTGTGTTAACATGTCGCTAGCCAGTGCTCCAGGCACCCAGCTTTGTCTGTGGGTTA
GTATTGGTGTATGTATGAGTATCTGTATGTATATATACACGGTATTTATAGAGAGAGACTATCCTGGAGAAGCCTCGTTTTGATGCCATT
CTTCCTTGCAAGGTTAAGCAAGGTGGGTGGAAACTAAGACACCTGAACCCTCCAGGGCCTCCCGCATCAAGGTCAGCATGAGGACAGACC
ACAGAGCTGTCACTTTTGCTCCGAAGCTACTTCTCCACTGTCCCGTTCAGTCTGAATGCTGCCACAACCAGCCAGGCAGGTCCACAGAGA
GGGAGAGCAGAGAAAGAAGTCCTTTCTCTTTATTGAGTTCGAGGACTACAACCAATTTACACTGCCATCTGATGCCGTGATCCTGAGCCA
AGGAGGTGAGGAGCAGAGCAGGCAATTTCACCACCAAATGCCAAGAAAAGGGCTGACATTTTCTTTCATGGGCACCAACCTGCATTTGTA
TGTGTCCCGAATCCACAGTCGTACTGATTCTAATGGGGACACAGATCATGGTAGAGAATCTCTCCCTCCTCAGTAAATGTACAACTGCAC
CTGTCATCATGGAGGTCATACATGCATACAAAGAGGTGTACAGGTACCATCTTGTATACACATATATACCCACATGTACAGACATACATT
TATGCACATTCACGCTGTTTGTTTCATATATACAGGCATAAAATAGAGTAAATACAGGTAGTTTTAAAAGTACCCTTTTGTGTGAATTGA
CTACCGTTGTTTGCAAACCCGAAAATAAAAGACGTTCATTATGTATGAAAAGTAACTGATTTGTATTCTGTGAGCATGTAAAAGCGGAAA
GTTAGTGCTTGTTCTAAGATTACCTTCTTGTTGATAAACCATAAATGAATCATCAAAGCTCACACCAAATTTTTCTATCAAATAAAACTA
GTGACAGCTTGTGGCTTTTTATTAGAGCTCGCCACGAACTAGGGTAAGGTGAGTGTCTTAGCATATTTTAATGCAGTTGCTTACTAAAGG
TTTTAACCGCACATGCACACACACACGCTTTCTTATGCAATCTATGTTTGCACTTGTGCTTTCAGTTAGCCTTCTGTAGGAAGTAGAAGT
CATATGTTGTCTTTGTTGTAGTGAAATTATACAGATAGAGTTCCATATATTGTATTTGTTTCAATGGTAAATCCTTTTGGAACATATAGA

>34999_34999_2_GSE1-CDH13_GSE1_chr16_85647004_ENST00000253458_CDH13_chr16_83520082_ENST00000566620_length(amino acids)=460AA_BP=7
MRGPGMKGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGL
TGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYE
ISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGW
LNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHP
NTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVL

--------------------------------------------------------------
>34999_34999_3_GSE1-CDH13_GSE1_chr16_85647004_ENST00000393243_CDH13_chr16_83520082_ENST00000268613_length(transcript)=1754nt_BP=47nt
CCAGCATGTATCAGCCGAGGTGGAGCTGCGGGGCCCTGGCATGAAAGGCACCACAGTGATGCGGATGACAGCCTTTGATGCAGATGACCC
AGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACATGTTCTACATCGATCCTGAGAA
AGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGACTCTGGAAAATCCCAAGTATGAACTGATCATCGAGGCTCAAGA
TATGGCTGGACTGGATGTTGGATTAACAGGCACGGCCACAGCCACGATCATGATCGATGACAAAAATGATCACTCACCAAAATTCACCAA
GAAAGAGTTTCAAGCCACAGTCGAGGAAGGAGCTGTGGGAGTTATTGTCAATTTGACAGTTGAAGATAAGGATGACCCCACCACAGGTGC
ATGGAGGGCTGCCTACACCATCATCAACGGAAACCCCGGGCAGAGCTTTGAAATCCACACCAACCCTCAAACCAACGAAGGGATGCTTTC
TGTTGTCAAACCATTGGACTATGAAATTTCTGCCTTCCACACCCTGCTGATCAAAGTGGAAAATGAAGACCCACTCGTACCCGACGTCTC
CTACGGCCCCAGCTCCACAGCCACCGTCCACATCACTGTCCTGGATGTCAACGAGGGCCCAGTCTTCTACCCAGACCCCATGATGGTGAC
CAGGCAGGAGGACCTCTCTGTGGGCAGCGTGCTGCTGACAGTGAATGCCACGGACCCCGACTCCCTGCAGCATCAAACCATCAGGTATTC
TGTTTACAAGGACCCAGCAGGTTGGCTGAATATTAACCCCATCAATGGGACTGTTGACACCACAGCTGTGCTGGACCGTGAGTCCCCATT
TGTCGACAACAGCGTGTACACTGCTCTCTTCCTGGCAATTGACAGTGGCAACCCTCCCGCTACGGGCACTGGGACTTTGCTGATAACCCT
GGAGGACGTGAATGACAATGCCCCGTTCATTTACCCCACAGTAGCTGAAGTCTGTGATGATGCCAAAAACCTCAGTGTAGTCATTTTGGG
AGCATCAGATAAGGATCTTCACCCGAATACAGATCCTTTCAAATTTGAAATCCACAAACAAGCTGTTCCTGATAAAGTCTGGAAGATCTC
CAAGATCAACAATACACACGCCCTGGTAAGCCTTCTTCAAAATCTGAACAAAGCAAACTACAACCTGCCCATCATGGTGACAGATTCAGG
GAAACCACCCATGACGAATATCACAGATCTCAGGGTACAAGTGTGCTCCTGCAGGAATTCCAAAGTGGACTGCAACGCGGCAGGGGCCCT
GCGCTTCAGCCTGCCCTCAGTCCTGCTCCTCAGCCTCTTCAGCTTAGCTTGTCTGTGAGAACTCCTGACGTCTGAAGCTTGACTCCCAAG
TTTCCATAGCAACAGGAAAAAAAAAAATCTATCCAAATCTGAAGATTGCGGTTTACAGCTATCGAACTTCACAACTAGGCCTCAATTGTT
CCGGTTTTTTATTTTCTTTACAATTTCACTTAGTCTGTACTTCATCATTTTGACAGCATCTTCCTCCCTCCTTTAATTAATGGAATCTTC
TGAATTTTCCCTGAATGTTTAAAGATCATGACATATGACTTGATCTTCTGGGAGCAGGAACAATGACTACTTTTTCTGGTGTGTTAACAT

>34999_34999_3_GSE1-CDH13_GSE1_chr16_85647004_ENST00000393243_CDH13_chr16_83520082_ENST00000268613_length(amino acids)=460AA_BP=7
MRGPGMKGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGL
TGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYE
ISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGW
LNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHP
NTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVL

--------------------------------------------------------------
>34999_34999_4_GSE1-CDH13_GSE1_chr16_85647004_ENST00000393243_CDH13_chr16_83520082_ENST00000566620_length(transcript)=2977nt_BP=47nt
CCAGCATGTATCAGCCGAGGTGGAGCTGCGGGGCCCTGGCATGAAAGGCACCACAGTGATGCGGATGACAGCCTTTGATGCAGATGACCC
AGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACATGTTCTACATCGATCCTGAGAA
AGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGACTCTGGAAAATCCCAAGTATGAACTGATCATCGAGGCTCAAGA
TATGGCTGGACTGGATGTTGGATTAACAGGCACGGCCACAGCCACGATCATGATCGATGACAAAAATGATCACTCACCAAAATTCACCAA
GAAAGAGTTTCAAGCCACAGTCGAGGAAGGAGCTGTGGGAGTTATTGTCAATTTGACAGTTGAAGATAAGGATGACCCCACCACAGGTGC
ATGGAGGGCTGCCTACACCATCATCAACGGAAACCCCGGGCAGAGCTTTGAAATCCACACCAACCCTCAAACCAACGAAGGGATGCTTTC
TGTTGTCAAACCATTGGACTATGAAATTTCTGCCTTCCACACCCTGCTGATCAAAGTGGAAAATGAAGACCCACTCGTACCCGACGTCTC
CTACGGCCCCAGCTCCACAGCCACCGTCCACATCACTGTCCTGGATGTCAACGAGGGCCCAGTCTTCTACCCAGACCCCATGATGGTGAC
CAGGCAGGAGGACCTCTCTGTGGGCAGCGTGCTGCTGACAGTGAATGCCACGGACCCCGACTCCCTGCAGCATCAAACCATCAGGTATTC
TGTTTACAAGGACCCAGCAGGTTGGCTGAATATTAACCCCATCAATGGGACTGTTGACACCACAGCTGTGCTGGACCGTGAGTCCCCATT
TGTCGACAACAGCGTGTACACTGCTCTCTTCCTGGCAATTGACAGTGGCAACCCTCCCGCTACGGGCACTGGGACTTTGCTGATAACCCT
GGAGGACGTGAATGACAATGCCCCGTTCATTTACCCCACAGTAGCTGAAGTCTGTGATGATGCCAAAAACCTCAGTGTAGTCATTTTGGG
AGCATCAGATAAGGATCTTCACCCGAATACAGATCCTTTCAAATTTGAAATCCACAAACAAGCTGTTCCTGATAAAGTCTGGAAGATCTC
CAAGATCAACAATACACACGCCCTGGTAAGCCTTCTTCAAAATCTGAACAAAGCAAACTACAACCTGCCCATCATGGTGACAGATTCAGG
GAAACCACCCATGACGAATATCACAGATCTCAGGGTACAAGTGTGCTCCTGCAGGAATTCCAAAGTGGACTGCAACGCGGCAGGGGCCCT
GCGCTTCAGCCTGCCCTCAGTCCTGCTCCTCAGCCTCTTCAGCTTAGCTTGTCTGTGAGAACTCCTGACGTCTGAAGCTTGACTCCCAAG
TTTCCATAGCAACAGGAAAAAAAAAAATCTATCCAAATCTGAAGATTGCGGTTTACAGCTATCGAACTTCACAACTAGGCCTCAATTGTT
CCGGTTTTTTATTTTCTTTACAATTTCACTTAGTCTGTACTTCATCATTTTGACAGCATCTTCCTCCCTCCTTTAATTAATGGAATCTTC
TGAATTTTCCCTGAATGTTTAAAGATCATGACATATGACTTGATCTTCTGGGAGCAGGAACAATGACTACTTTTTCTGGTGTGTTAACAT
GTCGCTAGCCAGTGCTCCAGGCACCCAGCTTTGTCTGTGGGTTAGTATTGGTGTATGTATGAGTATCTGTATGTATATATACACGGTATT
TATAGAGAGAGACTATCCTGGAGAAGCCTCGTTTTGATGCCATTCTTCCTTGCAAGGTTAAGCAAGGTGGGTGGAAACTAAGACACCTGA
ACCCTCCAGGGCCTCCCGCATCAAGGTCAGCATGAGGACAGACCACAGAGCTGTCACTTTTGCTCCGAAGCTACTTCTCCACTGTCCCGT
TCAGTCTGAATGCTGCCACAACCAGCCAGGCAGGTCCACAGAGAGGGAGAGCAGAGAAAGAAGTCCTTTCTCTTTATTGAGTTCGAGGAC
TACAACCAATTTACACTGCCATCTGATGCCGTGATCCTGAGCCAAGGAGGTGAGGAGCAGAGCAGGCAATTTCACCACCAAATGCCAAGA
AAAGGGCTGACATTTTCTTTCATGGGCACCAACCTGCATTTGTATGTGTCCCGAATCCACAGTCGTACTGATTCTAATGGGGACACAGAT
CATGGTAGAGAATCTCTCCCTCCTCAGTAAATGTACAACTGCACCTGTCATCATGGAGGTCATACATGCATACAAAGAGGTGTACAGGTA
CCATCTTGTATACACATATATACCCACATGTACAGACATACATTTATGCACATTCACGCTGTTTGTTTCATATATACAGGCATAAAATAG
AGTAAATACAGGTAGTTTTAAAAGTACCCTTTTGTGTGAATTGACTACCGTTGTTTGCAAACCCGAAAATAAAAGACGTTCATTATGTAT
GAAAAGTAACTGATTTGTATTCTGTGAGCATGTAAAAGCGGAAAGTTAGTGCTTGTTCTAAGATTACCTTCTTGTTGATAAACCATAAAT
GAATCATCAAAGCTCACACCAAATTTTTCTATCAAATAAAACTAGTGACAGCTTGTGGCTTTTTATTAGAGCTCGCCACGAACTAGGGTA
AGGTGAGTGTCTTAGCATATTTTAATGCAGTTGCTTACTAAAGGTTTTAACCGCACATGCACACACACACGCTTTCTTATGCAATCTATG
TTTGCACTTGTGCTTTCAGTTAGCCTTCTGTAGGAAGTAGAAGTCATATGTTGTCTTTGTTGTAGTGAAATTATACAGATAGAGTTCCAT
ATATTGTATTTGTTTCAATGGTAAATCCTTTTGGAACATATAGAATGCAGAGATTTTTTTTTCCATTAAAATAAATGGGTATTGGTGGTT

>34999_34999_4_GSE1-CDH13_GSE1_chr16_85647004_ENST00000393243_CDH13_chr16_83520082_ENST00000566620_length(amino acids)=460AA_BP=7
MRGPGMKGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGL
TGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYE
ISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGW
LNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHP
NTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GSE1-CDH13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GSE1-CDH13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GSE1-CDH13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource