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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKT3-PPP2R2A (FusionGDB2 ID:3503)

Fusion Gene Summary for AKT3-PPP2R2A

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT3-PPP2R2A
Fusion gene ID: 3503
HgeneTgene
Gene symbol

AKT3

PPP2R2A

Gene ID

10000

5520

Gene nameAKT serine/threonine kinase 3protein phosphatase 2 regulatory subunit Balpha
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2B55A|B55ALPHA|PR52A|PR55A|PR55alpha
Cytomap

1q43-q44

8p21.2

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformprotein phosphatase 2, regulatory subunit B, alpha
Modification date2020031320200327
UniProtAcc

Q9Y243

.
Ensembl transtripts involved in fusion geneENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
ENST00000492957, 		ENST00000523473, 
ENST00000315985, ENST00000380737, 
Fusion gene scores* DoF score18 X 15 X 7=18908 X 13 X 5=520
# samples 2113
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/520*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKT3 [Title/Abstract] AND PPP2R2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT3(244006427)-PPP2R2A(26211984), # samples:3
Anticipated loss of major functional domain due to fusion event.AKT3-PPP2R2A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-PPP2R2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-PPP2R2A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT3-PPP2R2A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AKT3-PPP2R2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819

TgenePPP2R2A

GO:0006470

protein dephosphorylation

1849734


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IL-01AAKT3chr1

244006427

-PPP2R2Achr8

26211984

+
ChimerDB4PRADTCGA-KK-A8ILAKT3chr1

244006427

-PPP2R2Achr8

26211984

+


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Fusion Gene ORF analysis for AKT3-PPP2R2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263826ENST00000523473AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
5CDS-intronENST00000336199ENST00000523473AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
5CDS-intronENST00000366539ENST00000523473AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
5CDS-intronENST00000366540ENST00000523473AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
Frame-shiftENST00000366540ENST00000315985AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
Frame-shiftENST00000366540ENST00000380737AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
In-frameENST00000263826ENST00000315985AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
In-frameENST00000263826ENST00000380737AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
In-frameENST00000336199ENST00000315985AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
In-frameENST00000336199ENST00000380737AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
In-frameENST00000366539ENST00000315985AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
In-frameENST00000366539ENST00000380737AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
intron-3CDSENST00000492957ENST00000315985AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
intron-3CDSENST00000492957ENST00000380737AKT3chr1

244006427

-PPP2R2Achr8

26211984

+
intron-intronENST00000492957ENST00000523473AKT3chr1

244006427

-PPP2R2Achr8

26211984

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1244006427-ENST00000380737PPP2R2Achr826211984+35431121901275361
ENST00000336199AKT3chr1244006427-ENST00000315985PPP2R2Achr826211984+17491121901275361
ENST00000366539AKT3chr1244006427-ENST00000380737PPP2R2Achr826211984+36782473251410361
ENST00000366539AKT3chr1244006427-ENST00000315985PPP2R2Achr826211984+18842473251410361
ENST00000263826AKT3chr1244006427-ENST00000380737PPP2R2Achr826211984+35581272051290361
ENST00000263826AKT3chr1244006427-ENST00000315985PPP2R2Achr826211984+17641272051290361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000380737AKT3chr1244006427-PPP2R2Achr826211984+0.0002483160.9997516
ENST00000336199ENST00000315985AKT3chr1244006427-PPP2R2Achr826211984+0.000415010.999585
ENST00000366539ENST00000380737AKT3chr1244006427-PPP2R2Achr826211984+0.0003033270.99969673
ENST00000366539ENST00000315985AKT3chr1244006427-PPP2R2Achr826211984+0.0005487180.9994512
ENST00000263826ENST00000380737AKT3chr1244006427-PPP2R2Achr826211984+0.0002636490.99973637
ENST00000263826ENST00000315985AKT3chr1244006427-PPP2R2Achr826211984+0.0005008330.9994992

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Fusion Genomic Features for AKT3-PPP2R2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AKT3chr1244006426-PPP2R2Achr826211983+4.28E-070.9999995
AKT3chr1244006426-PPP2R2Achr826211983+4.28E-070.9999995
AKT3chr1244006426-PPP2R2Achr826211983+4.28E-070.9999995
AKT3chr1244006426-PPP2R2Achr826211983+4.28E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AKT3-PPP2R2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:244006427/chr8:26211984)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT3

Q9Y243

.
FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000315985210175_21370458.0RepeatNote=WD 3
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000315985210224_26470458.0RepeatNote=WD 4
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000315985210283_32170458.0RepeatNote=WD 5
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000315985210338_37970458.0RepeatNote=WD 6
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000315985210414_44670458.0RepeatNote=WD 7
TgenePPP2R2Achr1:244006427chr8:26211984ENST0000031598521091_13270458.0RepeatNote=WD 2
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000380737210175_21360448.0RepeatNote=WD 3
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000380737210224_26460448.0RepeatNote=WD 4
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000380737210283_32160448.0RepeatNote=WD 5
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000380737210338_37960448.0RepeatNote=WD 6
TgenePPP2R2Achr1:244006427chr8:26211984ENST00000380737210414_44660448.0RepeatNote=WD 7
TgenePPP2R2Achr1:244006427chr8:26211984ENST0000038073721091_13260448.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:244006427chr8:26211984ENST00000263826-113148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr8:26211984ENST00000263826-113406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr8:26211984ENST00000263826-1135_10715480.0DomainPH
HgeneAKT3chr1:244006427chr8:26211984ENST00000336199-114148_40515476.0DomainProtein kinase
HgeneAKT3chr1:244006427chr8:26211984ENST00000336199-114406_47915476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr8:26211984ENST00000336199-1145_10715476.0DomainPH
HgeneAKT3chr1:244006427chr8:26211984ENST00000366539-214148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr8:26211984ENST00000366539-214406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr8:26211984ENST00000366539-2145_10715480.0DomainPH
HgeneAKT3chr1:244006427chr8:26211984ENST00000366540-214148_40515466.0DomainProtein kinase
HgeneAKT3chr1:244006427chr8:26211984ENST00000366540-214406_47915466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr8:26211984ENST00000366540-2145_10715466.0DomainPH
HgeneAKT3chr1:244006427chr8:26211984ENST00000263826-113154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr8:26211984ENST00000336199-114154_16215476.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr8:26211984ENST00000366539-214154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr8:26211984ENST00000366540-214154_16215466.0Nucleotide bindingATP
TgenePPP2R2Achr1:244006427chr8:26211984ENST0000031598521026_6570458.0RepeatNote=WD 1
TgenePPP2R2Achr1:244006427chr8:26211984ENST0000038073721026_6560448.0RepeatNote=WD 1


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Fusion Gene Sequence for AKT3-PPP2R2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3503_3503_1_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000263826_PPP2R2A_chr8_26211984_ENST00000315985_length(transcript)=1764nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGAACAAAATCCAGTCTCATAGCAGAGGAGAATATAATGTTTACAGCACCTTCCA
GAGCCATGAACCAGAGTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAAAATTAGGTGGTTACCCCAGAAAAATGCTGC
TCAGTTTTTATTGTCTACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGACAAAAGACCAGAAGGGTATAACTTGAAAGA
GGAGGATGGAAGGTATAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAGGCCTATGGATCTAATGGTTGAGGCCAGTCC
ACGAAGAATATTTGCCAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGATTATGAAACATATTTATCTGCAGATGATTT
GCGGATTAATCTTTGGCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAAGCCTGCCAATATGGAAGAGCTAACAGAGGT
GATTACAGCAGCAGAATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAAAGGAACTATTCGGCTATGTGACATGAGGGC
ATCTGCCCTCTGTGATAGACATTCTAAATTGTTTGAAGAACCTGAAGATCCCAGTAACAGGTCATTTTTTTCCGAAATCATCTCCTCTAT
TTCGGATGTAAAATTCAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGTCAAAATTTGGGACTTAAATATGGAAAACAG
GCCTGTGGAAACATACCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGAAAATGACTGCATATTTGACAAATTTGAATG
TTGTTGGAATGGATCTGACAGTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAATGTTTGACAGAAACACAAAGCGAGACATAAC
CCTAGAAGCATCGCGGGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTGTGCAAGTGGCAAGCGAAAGAAAGATGAAAT
AAGTGTTGACAGCCTAGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGAAAATATCATTGCCGTAGCTACTACAAACAA
TCTGTATATATTTCAAGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACTTCCTGCTTAGTTGAGATAGTTGAATCTAGC
ATTCGTTCCTATAAAAGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGTGCCATTCGACAACACATTGTTATAGCTACA
TGGAGAAAGCTCTGTGGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGTAAGGGTAGGGCACTTTTAATTTAAATGACT
TCTTGCACCATCTTGCCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACTTTTTATGCCTTCCATTGTGATGACGTCAAA
CACAGTGAAAGCCTTCAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCATTTGTGGGGTACACCCCTTCCCCCTTTTTT

>3503_3503_1_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000263826_PPP2R2A_chr8_26211984_ENST00000315985_length(amino acids)=361AA_BP=
MKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAH
TYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS
KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSV
VMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKV

--------------------------------------------------------------
>3503_3503_2_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000263826_PPP2R2A_chr8_26211984_ENST00000380737_length(transcript)=3558nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGAACAAAATCCAGTCTCATAGCAGAGGAGAATATAATGTTTACAGCACCTTCCA
GAGCCATGAACCAGAGTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAAAATTAGGTGGTTACCCCAGAAAAATGCTGC
TCAGTTTTTATTGTCTACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGACAAAAGACCAGAAGGGTATAACTTGAAAGA
GGAGGATGGAAGGTATAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAGGCCTATGGATCTAATGGTTGAGGCCAGTCC
ACGAAGAATATTTGCCAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGATTATGAAACATATTTATCTGCAGATGATTT
GCGGATTAATCTTTGGCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAAGCCTGCCAATATGGAAGAGCTAACAGAGGT
GATTACAGCAGCAGAATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAAAGGAACTATTCGGCTATGTGACATGAGGGC
ATCTGCCCTCTGTGATAGACATTCTAAATTGTTTGAAGAACCTGAAGATCCCAGTAACAGGTCATTTTTTTCCGAAATCATCTCCTCTAT
TTCGGATGTAAAATTCAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGTCAAAATTTGGGACTTAAATATGGAAAACAG
GCCTGTGGAAACATACCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGAAAATGACTGCATATTTGACAAATTTGAATG
TTGTTGGAATGGATCTGACAGTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAATGTTTGACAGAAACACAAAGCGAGACATAAC
CCTAGAAGCATCGCGGGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTGTGCAAGTGGCAAGCGAAAGAAAGATGAAAT
AAGTGTTGACAGCCTAGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGAAAATATCATTGCCGTAGCTACTACAAACAA
TCTGTATATATTTCAAGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACTTCCTGCTTAGTTGAGATAGTTGAATCTAGC
ATTCGTTCCTATAAAAGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGTGCCATTCGACAACACATTGTTATAGCTACA
TGGAGAAAGCTCTGTGGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGTAAGGGTAGGGCACTTTTAATTTAAATGACT
TCTTGCACCATCTTGCCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACTTTTTATGCCTTCCATTGTGATGACGTCAAA
CACAGTGAAAGCCTTCAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCATTTGTGGGGTACACCCCTTCCCCCTTTTTT
TAAATTAAATACAGCTCATTCTTACTGTGGCTTGTAGCATTCCTCCTCTTCTGGCCTCCTGGACTGCTCCCCTTCATCTCTTACCCTTGC
CCCCTCCACCCGGTCTTGGTGGTGGTATATTAAAAAAAGAAAGAATGAAAGCACACAAAATGAGTCAGTTTGGGGTCAGTGGTATAAAGG
GGGTATATGTTGCAAACAAATGTTTTAGTAACAGTTGGCTGTAATCACTCCTCGCCGTGTCTGGCACTGAAAATAAGGAAAAAAAACCTA
CTACTGAATAAAAGTGACAAAGAATGGAGAATCTGGTTTTCTTTTTCTTTTTAACCTACCTCTTGTAGCCAATATTTTGTGTCATACCTT
TGGGCACAGTGAAACAAAATGGGTTTTCATTGTTTATTGGTATTTTTGTTAATTATTTTTAACAAGTGTTCTTTTACATGCAGGAGGAGA
GGTATTGGTTCTCTATGAACATATTTTGAATATAGGTTTTATTAAGGATTTCACAATCTATAAATGCTACTAGTTTTTTTTTTTTTTTTT
ACCATCATGAGGGTATTGGATACATTGTGTCTCTATTTAACTCATTATGTGTTAATGAAATTGTTGTAAATGGGAACCAAATTTGTAGAA
CTTAATTTCTACTTTTTAGAGTGCTTAATTTCATTTTTGCCTTACTAAATAGTCAAAGACTTATAAAACATTTTTAACAAGTTAGAACTT
TTTTGTTATTCAGTCATATAAAATAGCAGAAAACTAACATCAAGTGACACTGCACTAAATACTTTTTTTGTATTTTACTGCTATCAAATC
AGAATGAAATATACTTTACCATAGATATTTTTCTTCTATTTTTGGTTTTCCAAAGCTATATGAAAGACAAATTTTTAAAGGTACAGCGTT
CAAAAAGTGCTTAATGAACTCCAACAGCTGCCTCAAATAAAAATCTGTATATGAATACATTTTCCCTAAGCGGTGATACATTATCCAAAG
ATGAAGAGTGCTCCTATTTTTAATAGGTAGAATGTACCTTTGTCAGTCTTGCAGAAACTTTAATGGAGAAGAAATGGACTTTATTTTTGA
AAGGTGAAATGAACAGGCATTTATATTATTAGAGAATGGTAGTCTTATTTTGGTGGAACATAATGTAACAACCTTGAATTTCAGAGGACT
CTGAGTGCTTCTATGTCCACTACCTATTGTTCTATTCTTCAATAATGAAAAAGAATTCAACGAGCCGACCGTGATTCCCTCTACTACAAA
TATTATGTCTTGTAAGTTAGCATTTTTAGCACACAGGAGAAATTTTATGTAATAAAATTACTGTATCTTTTGGATTTAACAAATTTGTAT
TTGAAACACATTCTATGTCTGATAATTCTTAATGGCACTTTTACTAATTTATTTGGGGATCTTGGGTACATTCTTAATTTGTGTTTATTC
TTCACGCTTGACTTGCAAGTGGGATATTCCCCTGCCACAAGTGTCAAACAGTGATATTCTTCCTGTGTTGTGACTGGACAGTTTTCCAGA
TCTTTTTTGGGAGATTTTCCTACAGCTTGGTTGTATGTCTTGAGATAACACCACCAAACAGCTCTCAGAAATTCTTTTTTGATTGATCAG
TAGCTATGATGATTCTCCTCCATGACACTAAGGATTAGTTTATATATTTAAGAGAAATAATTGCTAAAATTAAAATGCCTCTATCAAGGA
ATGCTATTATAAATTATTGTTAACATTCTCAAGTATTAATTTTTTAATTTCATTGGTGTAGCAAACTCTAAGCCCAGCCACTCATTTTAC

>3503_3503_2_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000263826_PPP2R2A_chr8_26211984_ENST00000380737_length(amino acids)=361AA_BP=
MKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAH
TYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS
KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSV
VMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKV

--------------------------------------------------------------
>3503_3503_3_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000336199_PPP2R2A_chr8_26211984_ENST00000315985_length(transcript)=1749nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGAACAAAATCCAGTCTCATAGCAGAGGAGAATATAATGTTTACAGCACCTTCCAGAGCCATGAACCAGA
GTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAAAATTAGGTGGTTACCCCAGAAAAATGCTGCTCAGTTTTTATTGTC
TACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGACAAAAGACCAGAAGGGTATAACTTGAAAGAGGAGGATGGAAGGTA
TAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAGGCCTATGGATCTAATGGTTGAGGCCAGTCCACGAAGAATATTTGC
CAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGATTATGAAACATATTTATCTGCAGATGATTTGCGGATTAATCTTTG
GCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAAGCCTGCCAATATGGAAGAGCTAACAGAGGTGATTACAGCAGCAGA
ATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAAAGGAACTATTCGGCTATGTGACATGAGGGCATCTGCCCTCTGTGA
TAGACATTCTAAATTGTTTGAAGAACCTGAAGATCCCAGTAACAGGTCATTTTTTTCCGAAATCATCTCCTCTATTTCGGATGTAAAATT
CAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGTCAAAATTTGGGACTTAAATATGGAAAACAGGCCTGTGGAAACATA
CCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGAAAATGACTGCATATTTGACAAATTTGAATGTTGTTGGAATGGATC
TGACAGTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAATGTTTGACAGAAACACAAAGCGAGACATAACCCTAGAAGCATCGCG
GGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTGTGCAAGTGGCAAGCGAAAGAAAGATGAAATAAGTGTTGACAGCCT
AGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGAAAATATCATTGCCGTAGCTACTACAAACAATCTGTATATATTTCA
AGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACTTCCTGCTTAGTTGAGATAGTTGAATCTAGCATTCGTTCCTATAAA
AGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGTGCCATTCGACAACACATTGTTATAGCTACATGGAGAAAGCTCTGT
GGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGTAAGGGTAGGGCACTTTTAATTTAAATGACTTCTTGCACCATCTTG
CCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACTTTTTATGCCTTCCATTGTGATGACGTCAAACACAGTGAAAGCCTT
CAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCATTTGTGGGGTACACCCCTTCCCCCTTTTTTTAAATTAAATACAGC

>3503_3503_3_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000336199_PPP2R2A_chr8_26211984_ENST00000315985_length(amino acids)=361AA_BP=
MKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAH
TYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS
KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSV
VMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKV

--------------------------------------------------------------
>3503_3503_4_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000336199_PPP2R2A_chr8_26211984_ENST00000380737_length(transcript)=3543nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGAACAAAATCCAGTCTCATAGCAGAGGAGAATATAATGTTTACAGCACCTTCCAGAGCCATGAACCAGA
GTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAAAATTAGGTGGTTACCCCAGAAAAATGCTGCTCAGTTTTTATTGTC
TACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGACAAAAGACCAGAAGGGTATAACTTGAAAGAGGAGGATGGAAGGTA
TAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAGGCCTATGGATCTAATGGTTGAGGCCAGTCCACGAAGAATATTTGC
CAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGATTATGAAACATATTTATCTGCAGATGATTTGCGGATTAATCTTTG
GCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAAGCCTGCCAATATGGAAGAGCTAACAGAGGTGATTACAGCAGCAGA
ATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAAAGGAACTATTCGGCTATGTGACATGAGGGCATCTGCCCTCTGTGA
TAGACATTCTAAATTGTTTGAAGAACCTGAAGATCCCAGTAACAGGTCATTTTTTTCCGAAATCATCTCCTCTATTTCGGATGTAAAATT
CAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGTCAAAATTTGGGACTTAAATATGGAAAACAGGCCTGTGGAAACATA
CCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGAAAATGACTGCATATTTGACAAATTTGAATGTTGTTGGAATGGATC
TGACAGTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAATGTTTGACAGAAACACAAAGCGAGACATAACCCTAGAAGCATCGCG
GGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTGTGCAAGTGGCAAGCGAAAGAAAGATGAAATAAGTGTTGACAGCCT
AGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGAAAATATCATTGCCGTAGCTACTACAAACAATCTGTATATATTTCA
AGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACTTCCTGCTTAGTTGAGATAGTTGAATCTAGCATTCGTTCCTATAAA
AGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGTGCCATTCGACAACACATTGTTATAGCTACATGGAGAAAGCTCTGT
GGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGTAAGGGTAGGGCACTTTTAATTTAAATGACTTCTTGCACCATCTTG
CCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACTTTTTATGCCTTCCATTGTGATGACGTCAAACACAGTGAAAGCCTT
CAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCATTTGTGGGGTACACCCCTTCCCCCTTTTTTTAAATTAAATACAGC
TCATTCTTACTGTGGCTTGTAGCATTCCTCCTCTTCTGGCCTCCTGGACTGCTCCCCTTCATCTCTTACCCTTGCCCCCTCCACCCGGTC
TTGGTGGTGGTATATTAAAAAAAGAAAGAATGAAAGCACACAAAATGAGTCAGTTTGGGGTCAGTGGTATAAAGGGGGTATATGTTGCAA
ACAAATGTTTTAGTAACAGTTGGCTGTAATCACTCCTCGCCGTGTCTGGCACTGAAAATAAGGAAAAAAAACCTACTACTGAATAAAAGT
GACAAAGAATGGAGAATCTGGTTTTCTTTTTCTTTTTAACCTACCTCTTGTAGCCAATATTTTGTGTCATACCTTTGGGCACAGTGAAAC
AAAATGGGTTTTCATTGTTTATTGGTATTTTTGTTAATTATTTTTAACAAGTGTTCTTTTACATGCAGGAGGAGAGGTATTGGTTCTCTA
TGAACATATTTTGAATATAGGTTTTATTAAGGATTTCACAATCTATAAATGCTACTAGTTTTTTTTTTTTTTTTTACCATCATGAGGGTA
TTGGATACATTGTGTCTCTATTTAACTCATTATGTGTTAATGAAATTGTTGTAAATGGGAACCAAATTTGTAGAACTTAATTTCTACTTT
TTAGAGTGCTTAATTTCATTTTTGCCTTACTAAATAGTCAAAGACTTATAAAACATTTTTAACAAGTTAGAACTTTTTTGTTATTCAGTC
ATATAAAATAGCAGAAAACTAACATCAAGTGACACTGCACTAAATACTTTTTTTGTATTTTACTGCTATCAAATCAGAATGAAATATACT
TTACCATAGATATTTTTCTTCTATTTTTGGTTTTCCAAAGCTATATGAAAGACAAATTTTTAAAGGTACAGCGTTCAAAAAGTGCTTAAT
GAACTCCAACAGCTGCCTCAAATAAAAATCTGTATATGAATACATTTTCCCTAAGCGGTGATACATTATCCAAAGATGAAGAGTGCTCCT
ATTTTTAATAGGTAGAATGTACCTTTGTCAGTCTTGCAGAAACTTTAATGGAGAAGAAATGGACTTTATTTTTGAAAGGTGAAATGAACA
GGCATTTATATTATTAGAGAATGGTAGTCTTATTTTGGTGGAACATAATGTAACAACCTTGAATTTCAGAGGACTCTGAGTGCTTCTATG
TCCACTACCTATTGTTCTATTCTTCAATAATGAAAAAGAATTCAACGAGCCGACCGTGATTCCCTCTACTACAAATATTATGTCTTGTAA
GTTAGCATTTTTAGCACACAGGAGAAATTTTATGTAATAAAATTACTGTATCTTTTGGATTTAACAAATTTGTATTTGAAACACATTCTA
TGTCTGATAATTCTTAATGGCACTTTTACTAATTTATTTGGGGATCTTGGGTACATTCTTAATTTGTGTTTATTCTTCACGCTTGACTTG
CAAGTGGGATATTCCCCTGCCACAAGTGTCAAACAGTGATATTCTTCCTGTGTTGTGACTGGACAGTTTTCCAGATCTTTTTTGGGAGAT
TTTCCTACAGCTTGGTTGTATGTCTTGAGATAACACCACCAAACAGCTCTCAGAAATTCTTTTTTGATTGATCAGTAGCTATGATGATTC
TCCTCCATGACACTAAGGATTAGTTTATATATTTAAGAGAAATAATTGCTAAAATTAAAATGCCTCTATCAAGGAATGCTATTATAAATT
ATTGTTAACATTCTCAAGTATTAATTTTTTAATTTCATTGGTGTAGCAAACTCTAAGCCCAGCCACTCATTTTACATGGCCATGGTTAAT

>3503_3503_4_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000336199_PPP2R2A_chr8_26211984_ENST00000380737_length(amino acids)=361AA_BP=
MKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAH
TYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS
KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSV
VMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKV

--------------------------------------------------------------
>3503_3503_5_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000366539_PPP2R2A_chr8_26211984_ENST00000315985_length(transcript)=1884nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGAACAAAATCCAGTCTCATAGCAG
AGGAGAATATAATGTTTACAGCACCTTCCAGAGCCATGAACCAGAGTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAA
AATTAGGTGGTTACCCCAGAAAAATGCTGCTCAGTTTTTATTGTCTACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGA
CAAAAGACCAGAAGGGTATAACTTGAAAGAGGAGGATGGAAGGTATAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAG
GCCTATGGATCTAATGGTTGAGGCCAGTCCACGAAGAATATTTGCCAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGA
TTATGAAACATATTTATCTGCAGATGATTTGCGGATTAATCTTTGGCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAA
GCCTGCCAATATGGAAGAGCTAACAGAGGTGATTACAGCAGCAGAATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAA
AGGAACTATTCGGCTATGTGACATGAGGGCATCTGCCCTCTGTGATAGACATTCTAAATTGTTTGAAGAACCTGAAGATCCCAGTAACAG
GTCATTTTTTTCCGAAATCATCTCCTCTATTTCGGATGTAAAATTCAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGT
CAAAATTTGGGACTTAAATATGGAAAACAGGCCTGTGGAAACATACCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGA
AAATGACTGCATATTTGACAAATTTGAATGTTGTTGGAATGGATCTGACAGTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAAT
GTTTGACAGAAACACAAAGCGAGACATAACCCTAGAAGCATCGCGGGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTG
TGCAAGTGGCAAGCGAAAGAAAGATGAAATAAGTGTTGACAGCCTAGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGA
AAATATCATTGCCGTAGCTACTACAAACAATCTGTATATATTTCAAGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACT
TCCTGCTTAGTTGAGATAGTTGAATCTAGCATTCGTTCCTATAAAAGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGT
GCCATTCGACAACACATTGTTATAGCTACATGGAGAAAGCTCTGTGGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGT
AAGGGTAGGGCACTTTTAATTTAAATGACTTCTTGCACCATCTTGCCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACT
TTTTATGCCTTCCATTGTGATGACGTCAAACACAGTGAAAGCCTTCAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCA

>3503_3503_5_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000366539_PPP2R2A_chr8_26211984_ENST00000315985_length(amino acids)=361AA_BP=
MKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAH
TYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS
KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSV
VMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKV

--------------------------------------------------------------
>3503_3503_6_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000366539_PPP2R2A_chr8_26211984_ENST00000380737_length(transcript)=3678nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGAACAAAATCCAGTCTCATAGCAG
AGGAGAATATAATGTTTACAGCACCTTCCAGAGCCATGAACCAGAGTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAA
AATTAGGTGGTTACCCCAGAAAAATGCTGCTCAGTTTTTATTGTCTACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGA
CAAAAGACCAGAAGGGTATAACTTGAAAGAGGAGGATGGAAGGTATAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAG
GCCTATGGATCTAATGGTTGAGGCCAGTCCACGAAGAATATTTGCCAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGA
TTATGAAACATATTTATCTGCAGATGATTTGCGGATTAATCTTTGGCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAA
GCCTGCCAATATGGAAGAGCTAACAGAGGTGATTACAGCAGCAGAATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAA
AGGAACTATTCGGCTATGTGACATGAGGGCATCTGCCCTCTGTGATAGACATTCTAAATTGTTTGAAGAACCTGAAGATCCCAGTAACAG
GTCATTTTTTTCCGAAATCATCTCCTCTATTTCGGATGTAAAATTCAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGT
CAAAATTTGGGACTTAAATATGGAAAACAGGCCTGTGGAAACATACCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGA
AAATGACTGCATATTTGACAAATTTGAATGTTGTTGGAATGGATCTGACAGTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAAT
GTTTGACAGAAACACAAAGCGAGACATAACCCTAGAAGCATCGCGGGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTG
TGCAAGTGGCAAGCGAAAGAAAGATGAAATAAGTGTTGACAGCCTAGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGA
AAATATCATTGCCGTAGCTACTACAAACAATCTGTATATATTTCAAGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACT
TCCTGCTTAGTTGAGATAGTTGAATCTAGCATTCGTTCCTATAAAAGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGT
GCCATTCGACAACACATTGTTATAGCTACATGGAGAAAGCTCTGTGGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGT
AAGGGTAGGGCACTTTTAATTTAAATGACTTCTTGCACCATCTTGCCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACT
TTTTATGCCTTCCATTGTGATGACGTCAAACACAGTGAAAGCCTTCAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCA
TTTGTGGGGTACACCCCTTCCCCCTTTTTTTAAATTAAATACAGCTCATTCTTACTGTGGCTTGTAGCATTCCTCCTCTTCTGGCCTCCT
GGACTGCTCCCCTTCATCTCTTACCCTTGCCCCCTCCACCCGGTCTTGGTGGTGGTATATTAAAAAAAGAAAGAATGAAAGCACACAAAA
TGAGTCAGTTTGGGGTCAGTGGTATAAAGGGGGTATATGTTGCAAACAAATGTTTTAGTAACAGTTGGCTGTAATCACTCCTCGCCGTGT
CTGGCACTGAAAATAAGGAAAAAAAACCTACTACTGAATAAAAGTGACAAAGAATGGAGAATCTGGTTTTCTTTTTCTTTTTAACCTACC
TCTTGTAGCCAATATTTTGTGTCATACCTTTGGGCACAGTGAAACAAAATGGGTTTTCATTGTTTATTGGTATTTTTGTTAATTATTTTT
AACAAGTGTTCTTTTACATGCAGGAGGAGAGGTATTGGTTCTCTATGAACATATTTTGAATATAGGTTTTATTAAGGATTTCACAATCTA
TAAATGCTACTAGTTTTTTTTTTTTTTTTTACCATCATGAGGGTATTGGATACATTGTGTCTCTATTTAACTCATTATGTGTTAATGAAA
TTGTTGTAAATGGGAACCAAATTTGTAGAACTTAATTTCTACTTTTTAGAGTGCTTAATTTCATTTTTGCCTTACTAAATAGTCAAAGAC
TTATAAAACATTTTTAACAAGTTAGAACTTTTTTGTTATTCAGTCATATAAAATAGCAGAAAACTAACATCAAGTGACACTGCACTAAAT
ACTTTTTTTGTATTTTACTGCTATCAAATCAGAATGAAATATACTTTACCATAGATATTTTTCTTCTATTTTTGGTTTTCCAAAGCTATA
TGAAAGACAAATTTTTAAAGGTACAGCGTTCAAAAAGTGCTTAATGAACTCCAACAGCTGCCTCAAATAAAAATCTGTATATGAATACAT
TTTCCCTAAGCGGTGATACATTATCCAAAGATGAAGAGTGCTCCTATTTTTAATAGGTAGAATGTACCTTTGTCAGTCTTGCAGAAACTT
TAATGGAGAAGAAATGGACTTTATTTTTGAAAGGTGAAATGAACAGGCATTTATATTATTAGAGAATGGTAGTCTTATTTTGGTGGAACA
TAATGTAACAACCTTGAATTTCAGAGGACTCTGAGTGCTTCTATGTCCACTACCTATTGTTCTATTCTTCAATAATGAAAAAGAATTCAA
CGAGCCGACCGTGATTCCCTCTACTACAAATATTATGTCTTGTAAGTTAGCATTTTTAGCACACAGGAGAAATTTTATGTAATAAAATTA
CTGTATCTTTTGGATTTAACAAATTTGTATTTGAAACACATTCTATGTCTGATAATTCTTAATGGCACTTTTACTAATTTATTTGGGGAT
CTTGGGTACATTCTTAATTTGTGTTTATTCTTCACGCTTGACTTGCAAGTGGGATATTCCCCTGCCACAAGTGTCAAACAGTGATATTCT
TCCTGTGTTGTGACTGGACAGTTTTCCAGATCTTTTTTGGGAGATTTTCCTACAGCTTGGTTGTATGTCTTGAGATAACACCACCAAACA
GCTCTCAGAAATTCTTTTTTGATTGATCAGTAGCTATGATGATTCTCCTCCATGACACTAAGGATTAGTTTATATATTTAAGAGAAATAA
TTGCTAAAATTAAAATGCCTCTATCAAGGAATGCTATTATAAATTATTGTTAACATTCTCAAGTATTAATTTTTTAATTTCATTGGTGTA

>3503_3503_6_AKT3-PPP2R2A_AKT3_chr1_244006427_ENST00000366539_PPP2R2A_chr8_26211984_ENST00000380737_length(amino acids)=361AA_BP=
MKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAH
TYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHS
KLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSV
VMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKT3-PPP2R2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKT3-PPP2R2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKT3-PPP2R2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource