Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GSS-TTI1 (FusionGDB2 ID:35100)

Fusion Gene Summary for GSS-TTI1

Fusion gene summary

Fusion gene information	Fusion gene name: GSS-TTI1
	Fusion gene ID: 35100
		Hgene	Tgene
	Gene symbol	GSS	TTI1
	Gene ID	5621	9675
	Gene name	prion protein	TELO2 interacting protein 1
	Synonyms	ASCR\|AltPrP\|CD230\|CJD\|GSS\|KURU\|PRIP\|PrP\|PrP27-30\|PrP33-35C\|PrPc\|p27-30	KIAA0406\|smg-10
	Cytomap	20p13	20q11.23
	Type of gene	protein-coding	protein-coding
	Description	major prion proteinalternative prion proteinCD230 antigenprion-related protein	TELO2-interacting protein 1 homologTEL2-interacting protein 1 homologTel two interacting protein 1smg-10 homolog, nonsense mediated mRNA decay factor
	Modification date	20200315	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000216951, ENST00000541098, ENST00000451957,	ENST00000487362, ENST00000373447, ENST00000373448, ENST00000449821,
Fusion gene scores	* DoF score	8 X 8 X 4=256	9 X 7 X 6=378
	# samples	10	9
	** MAII score	log2(10/256*10)=-1.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GSS [Title/Abstract] AND TTI1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GSS(33529516)-TTI1(36627730), # samples:1
Anticipated loss of major functional domain due to fusion event.	GSS-TTI1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GSS-TTI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GSS-TTI1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GSS	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	22820466
Hgene	GSS	GO:0071280	cellular response to copper ion	16254249

Fusion gene breakpoints across GSS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-55-8097-01A	GSS	chr20	33529516	-	TTI1	chr20	36627730	-

Top

Fusion Gene ORF analysis for GSS-TTI1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000216951	ENST00000487362	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
5CDS-intron	ENST00000541098	ENST00000487362	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
Frame-shift	ENST00000541098	ENST00000373447	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
Frame-shift	ENST00000541098	ENST00000373448	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
Frame-shift	ENST00000541098	ENST00000449821	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
In-frame	ENST00000216951	ENST00000373447	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
In-frame	ENST00000216951	ENST00000373448	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
In-frame	ENST00000216951	ENST00000449821	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
intron-3CDS	ENST00000451957	ENST00000373447	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
intron-3CDS	ENST00000451957	ENST00000373448	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
intron-3CDS	ENST00000451957	ENST00000449821	GSS	chr20	33529516	-	TTI1	chr20	36627730	-
intron-intron	ENST00000451957	ENST00000487362	GSS	chr20	33529516	-	TTI1	chr20	36627730	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000216951	GSS	chr20	33529516	-	ENST00000373448	TTI1	chr20	36627730	-	1774	707	99	935	278
ENST00000216951	GSS	chr20	33529516	-	ENST00000373447	TTI1	chr20	36627730	-	1774	707	99	935	278
ENST00000216951	GSS	chr20	33529516	-	ENST00000449821	TTI1	chr20	36627730	-	1759	707	99	935	278

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216951	ENST00000373448	GSS	chr20	33529516	-	TTI1	chr20	36627730	-	0.21565895	0.7843411
ENST00000216951	ENST00000373447	GSS	chr20	33529516	-	TTI1	chr20	36627730	-	0.21565895	0.7843411
ENST00000216951	ENST00000449821	GSS	chr20	33529516	-	TTI1	chr20	36627730	-	0.22243443	0.77756554

Top

Fusion Genomic Features for GSS-TTI1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GSS-TTI1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33529516/chr20:36627730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000216951

148_151

202

475.0

Region

Note=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000216951

364_373

202

475.0

Nucleotide binding

Note=ATP

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000216951

398_401

202

475.0

Nucleotide binding

Note=ATP

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000451957

364_373

364.0

Nucleotide binding

Note=ATP

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000451957

398_401

364.0

Nucleotide binding

Note=ATP

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000216951

214_216

202

475.0

Region

Note=Substrate binding

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000216951

267_270

202

475.0

Region

Note=Substrate binding

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000216951

461_462

202

475.0

Region

Note=Substrate binding

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000451957

148_151

364.0

Region

Note=Substrate binding

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000451957

214_216

364.0

Region

Note=Substrate binding

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000451957

267_270

364.0

Region

Note=Substrate binding

Hgene

GSS

chr20:33529516

chr20:36627730

ENST00000451957

461_462

364.0

Region

Note=Substrate binding

Tgene

TTI1

chr20:33529516

chr20:36627730

ENST00000373447

833_836

884

1090.0

Compositional bias

Note=Poly-Glu

Tgene

TTI1

chr20:33529516

chr20:36627730

ENST00000373448

833_836

884

1090.0

Compositional bias

Note=Poly-Glu

Tgene

TTI1

chr20:33529516

chr20:36627730

ENST00000449821

833_836

884

1090.0

Compositional bias

Note=Poly-Glu

Top

Fusion Gene Sequence for GSS-TTI1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>35100_35100_1_GSS-TTI1_GSS_chr20_33529516_ENST00000216951_TTI1_chr20_36627730_ENST00000373447_length(transcript)=1774nt_BP=707nt
AAGCGCACTGGGTCGCATCGAGGCCCCGCCCCCTGAGCCTGGGTAGCGGCGCGAGGGCCGGGAGAACCGTTCGCGGAGGAAAGGCGAACT
AGTGTTGGGATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTG
GCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTC
CCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAG
CAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAG
ACTGTGTTCCTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACC
ATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGC
AAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGC
TGGATCTGTGTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCA
CACGGGACGCCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCT
GCAAAGATGTCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGG
CCTTCAAGTTGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTG
ATGCCTGCTTGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACC
CAGACTCCACCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACG
GGGCCAGCGGGCAGCAGAACCCCTACACGACCAACGTGCTCCAGCTGCTCAAGGAGCTGCAGTGACCCTGCTCCCCCACCACAGAGGCCA
CCGATCCCTCCCCTACTGCCAGCCAGAAGCTGGGCTGACCCCACCCCGGCCATAGGCGGTGGCAGCGGCAGCAGAGAAGGTGAATTAGTT
AGCCAATCGATTTATAAATTGATCGATCACACAACTGCTTAGAAATGGATTGAAGGAAAGTAGCTGACTATTATTTATGTTTCATACCTT
GTGTTGTCAAGTGACATTGTCTGGTGGCTCTAAGGGTTTAACCCCTTAGCCTACCATCTCTATAGCCCCAGCTCCCTCACAGGCCACACA
CACACACACACAAGAGGTCAGTTCCCCTCCATCTGCATACACCTCCCTGTCTTCAAATAATGAGATGGAACTAATTTGTTTTACCTAACC

>35100_35100_1_GSS-TTI1_GSS_chr20_33529516_ENST00000216951_TTI1_chr20_36627730_ENST00000373447_length(amino acids)=278AA_BP=203
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTL
SSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPKSWMCWICVWLFFSPTKTSCFPWLIRPGPRSFTDSHGTPPWQCLEPSRFYVPWEASVVTFFAAGSAKM

--------------------------------------------------------------
>35100_35100_2_GSS-TTI1_GSS_chr20_33529516_ENST00000216951_TTI1_chr20_36627730_ENST00000373448_length(transcript)=1774nt_BP=707nt
AAGCGCACTGGGTCGCATCGAGGCCCCGCCCCCTGAGCCTGGGTAGCGGCGCGAGGGCCGGGAGAACCGTTCGCGGAGGAAAGGCGAACT
AGTGTTGGGATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTG
GCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTC
CCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAG
CAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAG
ACTGTGTTCCTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACC
ATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGC
AAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGC
TGGATCTGTGTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCA
CACGGGACGCCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCT
GCAAAGATGTCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGG
CCTTCAAGTTGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTG
ATGCCTGCTTGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACC
CAGACTCCACCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACG
GGGCCAGCGGGCAGCAGAACCCCTACACGACCAACGTGCTCCAGCTGCTCAAGGAGCTGCAGTGACCCTGCTCCCCCACCACAGAGGCCA
CCGATCCCTCCCCTACTGCCAGCCAGAAGCTGGGCTGACCCCACCCCGGCCATAGGCGGTGGCAGCGGCAGCAGAGAAGGTGAATTAGTT
AGCCAATCGATTTATAAATTGATCGATCACACAACTGCTTAGAAATGGATTGAAGGAAAGTAGCTGACTATTATTTATGTTTCATACCTT
GTGTTGTCAAGTGACATTGTCTGGTGGCTCTAAGGGTTTAACCCCTTAGCCTACCATCTCTATAGCCCCAGCTCCCTCACAGGCCACACA
CACACACACACAAGAGGTCAGTTCCCCTCCATCTGCATACACCTCCCTGTCTTCAAATAATGAGATGGAACTAATTTGTTTTACCTAACC

>35100_35100_2_GSS-TTI1_GSS_chr20_33529516_ENST00000216951_TTI1_chr20_36627730_ENST00000373448_length(amino acids)=278AA_BP=203
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTL
SSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPKSWMCWICVWLFFSPTKTSCFPWLIRPGPRSFTDSHGTPPWQCLEPSRFYVPWEASVVTFFAAGSAKM

--------------------------------------------------------------
>35100_35100_3_GSS-TTI1_GSS_chr20_33529516_ENST00000216951_TTI1_chr20_36627730_ENST00000449821_length(transcript)=1759nt_BP=707nt
AAGCGCACTGGGTCGCATCGAGGCCCCGCCCCCTGAGCCTGGGTAGCGGCGCGAGGGCCGGGAGAACCGTTCGCGGAGGAAAGGCGAACT
AGTGTTGGGATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTG
GCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTC
CCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAG
CAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAG
ACTGTGTTCCTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACC
ATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGC
AAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGC
TGGATCTGTGTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCA
CACGGGACGCCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCT
GCAAAGATGTCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGG
CCTTCAAGTTGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTG
ATGCCTGCTTGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACC
CAGACTCCACCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACG
GGGCCAGCGGGCAGCAGAACCCCTACACGACCAACGTGCTCCAGCTGCTCAAGGAGCTGCAGTGACCCTGCTCCCCCACCACAGAGGCCA
CCGATCCCTCCCCTACTGCCAGCCAGAAGCTGGGCTGACCCCACCCCGGCCATAGGCGGTGGCAGCGGCAGCAGAGAAGGTGAATTAGTT
AGCCAATCGATTTATAAATTGATCGATCACACAACTGCTTAGAAATGGATTGAAGGAAAGTAGCTGACTATTATTTATGTTTCATACCTT
GTGTTGTCAAGTGACATTGTCTGGTGGCTCTAAGGGTTTAACCCCTTAGCCTACCATCTCTATAGCCCCAGCTCCCTCACAGGCCACACA
CACACACACACAAGAGGTCAGTTCCCCTCCATCTGCATACACCTCCCTGTCTTCAAATAATGAGATGGAACTAATTTGTTTTACCTAACC

>35100_35100_3_GSS-TTI1_GSS_chr20_33529516_ENST00000216951_TTI1_chr20_36627730_ENST00000449821_length(amino acids)=278AA_BP=203
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTL
SSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPKSWMCWICVWLFFSPTKTSCFPWLIRPGPRSFTDSHGTPPWQCLEPSRFYVPWEASVVTFFAAGSAKM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GSS-TTI1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GSS-TTI1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GSS-TTI1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source