Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GSTO1-INA (FusionGDB2 ID:35120)

Fusion Gene Summary for GSTO1-INA

Fusion gene summary

Fusion gene information	Fusion gene name: GSTO1-INA
	Fusion gene ID: 35120
		Hgene	Tgene
	Gene symbol	GSTO1	INA
	Gene ID	9446	9118
	Gene name	glutathione S-transferase omega 1	internexin neuronal intermediate filament protein alpha
	Synonyms	GSTO 1-1\|GSTTLp28\|HEL-S-21\|P28\|SPG-R	NEF5\|NF-66\|TXBP-1
	Cytomap	10q25.1	10q24.33
	Type of gene	protein-coding	protein-coding
	Description	glutathione S-transferase omega-1MMA(V) reductaseS-(Phenacyl)glutathione reductaseepididymis secretory protein Li 21glutathione S-transferase omega 1-1glutathione-S-transferase likeglutathione-dependent dehydroascorbate reductasemonomethylarsonic a	alpha-internexin66 kDa neurofilament proteinalpha-Inxneurofilament 5 (66kD)neurofilament-66, tax-binding protein
	Modification date	20200313	20200313
	UniProtAcc	P78417	Q3KP66
	Ensembl transtripts involved in fusion gene	ENST00000493946, ENST00000369713, ENST00000539281, ENST00000369710,	ENST00000369849,
Fusion gene scores	* DoF score	6 X 5 X 2=60	4 X 2 X 3=24
	# samples	6	5
	** MAII score	log2(6/60*10)=0	log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GSTO1 [Title/Abstract] AND INA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GSTO1(106022835)-INA(105046792), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GSTO1	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	11035031
Hgene	GSTO1	GO:0019852	L-ascorbic acid metabolic process	11511179
Hgene	GSTO1	GO:0042178	xenobiotic catabolic process	12928150
Hgene	GSTO1	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	11035031
Hgene	GSTO1	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	11035031
Hgene	GSTO1	GO:0071243	cellular response to arsenic-containing substance	11511179

Fusion gene breakpoints across GSTO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across INA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-8474-01A	GSTO1	chr10	106022835	+	INA	chr10	105046792	+

Top

Fusion Gene ORF analysis for GSTO1-INA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000493946	ENST00000369849	GSTO1	chr10	106022835	+	INA	chr10	105046792	+
In-frame	ENST00000369713	ENST00000369849	GSTO1	chr10	106022835	+	INA	chr10	105046792	+
In-frame	ENST00000539281	ENST00000369849	GSTO1	chr10	106022835	+	INA	chr10	105046792	+
intron-3CDS	ENST00000369710	ENST00000369849	GSTO1	chr10	106022835	+	INA	chr10	105046792	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000539281

GSTO1

chr10

106022835

ENST00000369849

INA

chr10

105046792

2854

737

284

1171

295

ENST00000369713

GSTO1

chr10

106022835

ENST00000369849

INA

chr10

105046792

2776

659

146

1093

315

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000539281	ENST00000369849	GSTO1	chr10	106022835	+	INA	chr10	105046792	+	0.00043403	0.999566
ENST00000369713	ENST00000369849	GSTO1	chr10	106022835	+	INA	chr10	105046792	+	0.000496648	0.9995034

Top

Fusion Genomic Features for GSTO1-INA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GSTO1	chr10	106022835	+	INA	chr10	105046791	+	7.57E-08	0.9999999
GSTO1	chr10	106022835	+	INA	chr10	105046791	+	7.57E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GSTO1-INA

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:106022835/chr10:105046792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GSTO1 P78417	INA Q3KP66
FUNCTION: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269\|PubMed:10783391, ECO:0000269\|PubMed:11511179, ECO:0000269\|PubMed:17226937, ECO:0000269\|PubMed:18028863, ECO:0000269\|PubMed:21106529}.	FUNCTION: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269\|PubMed:28436939, ECO:0000269\|PubMed:29420262}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000369713

22_101

155

242.0

Domain

Note=GST N-terminal

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000539281

22_101

127

214.0

Domain

Note=GST N-terminal

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000369713

85_86

155

242.0

Region

Glutathione binding

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000539281

85_86

127

214.0

Region

Glutathione binding

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

449_454

355

500.0

Compositional bias

Note=Poly-Glu

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

409_499

355

500.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000369710

106_230

209.0

Domain

Note=GST C-terminal

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000369710

22_101

209.0

Domain

Note=GST N-terminal

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000369713

106_230

155

242.0

Domain

Note=GST C-terminal

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000539281

106_230

127

214.0

Domain

Note=GST C-terminal

Hgene

GSTO1

chr10:106022835

chr10:105046792

ENST00000369710

85_86

209.0

Region

Glutathione binding

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

94_407

355

500.0

Domain

IF rod

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

130_142

355

500.0

Region

Note=Linker 1

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

143_238

355

500.0

Region

Note=Coil 1B

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

1_87

355

500.0

Region

Note=Head

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

239_262

355

500.0

Region

Note=Linker 2

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

263_408

355

500.0

Region

Note=Coil 2

Tgene

INA

chr10:106022835

chr10:105046792

ENST00000369849

88_129

355

500.0

Region

Note=Coil 1A

Top

Fusion Gene Sequence for GSTO1-INA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>35120_35120_1_GSTO1-INA_GSTO1_chr10_106022835_ENST00000369713_INA_chr10_105046792_ENST00000369849_length(transcript)=2776nt_BP=659nt
ACAGCCCCTTAAGATGTTTTAAGGGCTATCCCATAAAGCCGGGAAGGCACAACGGGTGGAGCTGGCGGCCGCCGGGGGCAGGCACTTTTG
AGCTAAGGAGGAAGCGGGGGAGGGAAGGAGGGCGGGAAGGACGCGCCACCTACTTCCTGAATCCCCTGCAAACCCCAGAGGAGCTCGGCC
TGCGCTGCGCCACGATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCGGAGGGCTCGATCCGCA
TCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACC
TGAAAAATAAGCCTGAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGT
CTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGA
TCTTAGAGTTGTTTTCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAAT
TTCGTAAAGAATTTACCAAGCTAGAGGAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACC
TTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACAC
GTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAA
CCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGA
TAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAA
GCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAAC
TATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACC
CCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAG
TGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATT
CATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACAC
CCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTC
TTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGC
TCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTC
TGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAG
CTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGT
GATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAG
TTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAG
GCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAG
AAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCAT
GGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTA
GATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTG
TTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACAT
GATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCT

>35120_35120_1_GSTO1-INA_GSTO1_chr10_106022835_ENST00000369713_INA_chr10_105046792_ENST00000369849_length(amino acids)=315AA_BP=171
MNPLQTPEELGLRCATMSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPV
LENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEDSIGQLEND
LRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEE

--------------------------------------------------------------
>35120_35120_2_GSTO1-INA_GSTO1_chr10_106022835_ENST00000539281_INA_chr10_105046792_ENST00000369849_length(transcript)=2854nt_BP=737nt
AAGGATGACTCCTAGACCTGTCTTTGTCCCATACTTGGGAAGATAAGCTGTTAGTTTACATTGCCAAGATGAAATTCAACTGATCTGTTT
TAGAGTAAAGATCTTGCGGGCCAACAAGGAATTTCCTTGGGGAGGTGTGTGGCCTTTGATCTTTGTAGCTATTTAGCAACAAAATGGGAG
GCAGTGTTGCCTGACTCAGTTTCCAAGCTTGACTCTTCCCTTTGGCATAGTGAGTTTGGAGTCAAGAGATTTTTATTTTCCCTTCACAAG
CTGAACAGGAGCCTTTGGAGAGAACGCTCTGGACCGGAAGCGCGCCCCCGGGGCCGGTCCCGGAGGGCTCGATCCGCATCTACAGCATGA
GGTTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGC
CTGAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGTCTGCCATCACCT
GTGAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGT
TTTCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAATTTCGTAAAGAAT
TTACCAAGCTAGAGGAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACC
AGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCA
GTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCT
CATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTT
TTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATAT
AATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGC
CACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAA
GTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATT
CAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAG
CCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTC
TGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGA
AAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGG
GTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAA
AAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATC
TATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGAC
CTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGT
GATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCA
CTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTG
GTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTT
GGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAG
TCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAG
CAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACT
GAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCT

>35120_35120_2_GSTO1-INA_GSTO1_chr10_106022835_ENST00000539281_INA_chr10_105046792_ENST00000369849_length(amino acids)=295AA_BP=151
MERTLWTGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLD
EAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEDSIGQLENDLRNTKSEMARHLREYQDLLN
VKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEIL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GSTO1-INA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GSTO1-INA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GSTO1-INA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source