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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GSTP1-KRT14 (FusionGDB2 ID:35136)

Fusion Gene Summary for GSTP1-KRT14

Fusion gene summary

Fusion gene information	Fusion gene name: GSTP1-KRT14
	Fusion gene ID: 35136
		Hgene	Tgene
	Gene symbol	GSTP1	KRT14
	Gene ID	2950	3861
	Gene name	glutathione S-transferase pi 1	keratin 14
	Synonyms	DFN7\|FAEES3\|GST3\|GSTP\|HEL-S-22\|PI	CK14\|EBS3\|EBS4\|K14\|NFJ
	Cytomap	11q13.2	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	glutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III	keratin, type I cytoskeletal 14cytokeratin 14keratin 14, type I
	Modification date	20200329	20200313
	UniProtAcc	P09211	P02533
	Ensembl transtripts involved in fusion gene	ENST00000498765, ENST00000398603, ENST00000398606,	ENST00000167586,
Fusion gene scores	* DoF score	16 X 13 X 5=1040	19 X 28 X 6=3192
	# samples	16	23
	** MAII score	log2(16/1040*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/3192*10)=-3.79475488527797 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GSTP1 [Title/Abstract] AND KRT14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GSTP1(67352630)-KRT14(39739709), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GSTP1	GO:0006469	negative regulation of protein kinase activity	16636664
Hgene	GSTP1	GO:0006749	glutathione metabolic process	1540159
Hgene	GSTP1	GO:0006805	xenobiotic metabolic process	1540159
Hgene	GSTP1	GO:0009890	negative regulation of biosynthetic process	18962899
Hgene	GSTP1	GO:0032691	negative regulation of interleukin-1 beta production	18962899
Hgene	GSTP1	GO:0032720	negative regulation of tumor necrosis factor production	18962899
Hgene	GSTP1	GO:0043407	negative regulation of MAP kinase activity	11408560
Hgene	GSTP1	GO:0043508	negative regulation of JUN kinase activity	16636664
Hgene	GSTP1	GO:0043651	linoleic acid metabolic process	16624487
Hgene	GSTP1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	18962899
Hgene	GSTP1	GO:0070373	negative regulation of ERK1 and ERK2 cascade	11408560
Hgene	GSTP1	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	18962899
Hgene	GSTP1	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	16636664
Tgene	KRT14	GO:0007568	aging	21916889
Tgene	KRT14	GO:0042633	hair cycle	21916889

Fusion gene breakpoints across GSTP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KRT14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-A6K1	GSTP1	chr11	67352630	+	KRT14	chr17	39739709	-

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Fusion Gene ORF analysis for GSTP1-KRT14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000498765	ENST00000167586	GSTP1	chr11	67352630	+	KRT14	chr17	39739709	-
In-frame	ENST00000398603	ENST00000167586	GSTP1	chr11	67352630	+	KRT14	chr17	39739709	-
In-frame	ENST00000398606	ENST00000167586	GSTP1	chr11	67352630	+	KRT14	chr17	39739709	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000398606

GSTP1

chr11

67352630

ENST00000167586

KRT14

chr17

39739709

1085

563

218

928

236

ENST00000398603

GSTP1

chr11

67352630

ENST00000167586

KRT14

chr17

39739709

938

416

781

236

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398606	ENST00000167586	GSTP1	chr11	67352630	+	KRT14	chr17	39739709	-	0.011458299	0.9885417
ENST00000398603	ENST00000167586	GSTP1	chr11	67352630	+	KRT14	chr17	39739709	-	0.010695524	0.9893044

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Fusion Genomic Features for GSTP1-KRT14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GSTP1-KRT14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:67352630/chr17:39739709)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GSTP1 P09211	KRT14 P02533
FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269\|PubMed:21046276, ECO:0000269\|PubMed:21668448, ECO:0000269\|PubMed:9084911}.	FUNCTION: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269\|PubMed:11724817}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

423_472

351

473.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSTP1

chr11:67352630

chr17:39739709

ENST00000398606

2_81

211.0

Domain

Note=GST N-terminal

Hgene

GSTP1

chr11:67352630

chr17:39739709

ENST00000398606

83_204

211.0

Domain

Note=GST C-terminal

Hgene

GSTP1

chr11:67352630

chr17:39739709

ENST00000398606

52_53

211.0

Region

Glutathione binding

Hgene

GSTP1

chr11:67352630

chr17:39739709

ENST00000398606

65_66

211.0

Region

Glutathione binding

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

115_426

351

473.0

Domain

IF rod

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

115_150

351

473.0

Region

Note=Coil 1A

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

151_168

351

473.0

Region

Note=Linker 1

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

169_260

351

473.0

Region

Note=Coil 1B

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

1_114

351

473.0

Region

Note=Head

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

261_283

351

473.0

Region

Note=Linker 12

Tgene

KRT14

chr11:67352630

chr17:39739709

ENST00000167586

284_422

351

473.0

Region

Note=Coil 2

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Fusion Gene Sequence for GSTP1-KRT14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>35136_35136_1_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398603_KRT14_chr17_39739709_ENST00000167586_length(transcript)=938nt_BP=416nt
GCCGTGACTCAGCACTGGGGCGGAGCGGGGCGGGACCACCCTTATAAGGCTCGGAGGCCGCGAGGCCTTCGCTGGAGTTTCGCCGCCGCA
GTCTTCGCCACCATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATGCTGCTGGCAGATCAGGGC
CAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAGGAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTC
CAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGAGGCAGCCCTGGTGGACATGGTGA
ATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACCAACTATAAAGCATCCCTGGAGAACAGCCTGGAGGAGACCA
AAGGTCGCTACTGCATGCAGCTGGCCCAGATCCAGGAGATGATTGGCAGCGTGGAGGAGCAGCTGGCCCAGCTCCGCTGCGAGATGGAGC
AGCAGAACCAGGAGTACAAGATCCTGCTGGACGTGAAGACGCGGCTGGAGCAGGAGATCGCCACCTACCGCCGCCTGCTGGAGGGCGAGG
ACGCCCACCTCTCCTCCTCCCAGTTCTCCTCTGGATCGCAGTCATCCAGAGATGTGACCTCCTCCAGCCGCCAAATCCGCACCAAGGTCA
TGGATGTGCACGATGGCAAGGTGGTGTCCACCCACGAGCAGGTCCTTCGCACCAAGAACTGAGGCTGCCCAGCCCCGCTCAGGCCTAGGA
GGCCCCCCGTGTGGACACAGATCCCACTGGAAGATCCCCTCTCCTGCCCAAGCACTTCACAGCTGGACCCTGCTTCACCCTCACCCCCTC

>35136_35136_1_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398603_KRT14_chr17_39739709_ENST00000167586_length(amino acids)=236AA_BP=21
MEFRRRSLRHHAALHRGLFPSSRPLRGPAHAAGRSGPELEGGGGDRGDVAGGLTQSLLPIRAAPQVPGRRPHPVPVQYHPASPGPHPWEA
ALVDMVNDGVEDLRCKYISLIYTNYKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYR

--------------------------------------------------------------
>35136_35136_2_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398606_KRT14_chr17_39739709_ENST00000167586_length(transcript)=1085nt_BP=563nt
TGGGAAAGAGGGAAAGGCTTCCCCGGCCAGCTGCGCGGCGACTCCGGGGACTCCAGGGCGCCCCTCTGCGGCCGACGCCCGGGGTGCAGC
GGCCGCCGGGGCTGGGGCCGGCGGGAGTCCGCGGGACCCTCCAGAAGAGCGGCCGGCGCCGTGACTCAGCACTGGGGCGGAGCGGGGCGG
GACCACCCTTATAAGGCTCGGAGGCCGCGAGGCCTTCGCTGGAGTTTCGCCGCCGCAGTCTTCGCCACCATGCCGCCCTACACCGTGGTC
TATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATGCTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAG
ACGTGGCAGGAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAAT
ACCATCCTGCGTCACCTGGGCCGCACCCTTGGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACA
TCTCCCTCATCTACACCAACTATAAAGCATCCCTGGAGAACAGCCTGGAGGAGACCAAAGGTCGCTACTGCATGCAGCTGGCCCAGATCC
AGGAGATGATTGGCAGCGTGGAGGAGCAGCTGGCCCAGCTCCGCTGCGAGATGGAGCAGCAGAACCAGGAGTACAAGATCCTGCTGGACG
TGAAGACGCGGCTGGAGCAGGAGATCGCCACCTACCGCCGCCTGCTGGAGGGCGAGGACGCCCACCTCTCCTCCTCCCAGTTCTCCTCTG
GATCGCAGTCATCCAGAGATGTGACCTCCTCCAGCCGCCAAATCCGCACCAAGGTCATGGATGTGCACGATGGCAAGGTGGTGTCCACCC
ACGAGCAGGTCCTTCGCACCAAGAACTGAGGCTGCCCAGCCCCGCTCAGGCCTAGGAGGCCCCCCGTGTGGACACAGATCCCACTGGAAG
ATCCCCTCTCCTGCCCAAGCACTTCACAGCTGGACCCTGCTTCACCCTCACCCCCTCCTGGCAATCAATACAGCTTCATTATCTGAGTTG

>35136_35136_2_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398606_KRT14_chr17_39739709_ENST00000167586_length(amino acids)=236AA_BP=21
MEFRRRSLRHHAALHRGLFPSSRPLRGPAHAAGRSGPELEGGGGDRGDVAGGLTQSLLPIRAAPQVPGRRPHPVPVQYHPASPGPHPWEA
ALVDMVNDGVEDLRCKYISLIYTNYKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GSTP1-KRT14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	KRT14	chr11:67352630	chr17:39739709	ENST00000167586		4	8	425_472	351.0	473.0	Type I keratins and keratin filaments

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GSTP1-KRT14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GSTP1-KRT14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source