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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GTDC1-ARHGAP35 (FusionGDB2 ID:35151)

Fusion Gene Summary for GTDC1-ARHGAP35

check button Fusion gene summary
Fusion gene informationFusion gene name: GTDC1-ARHGAP35
Fusion gene ID: 35151
HgeneTgene
Gene symbol

GTDC1

ARHGAP35

Gene ID

79712

2909

Gene nameglycosyltransferase like domain containing 1Rho GTPase activating protein 35
SynonymsHmat-Xa|mat-XaGRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP
Cytomap

2q22.3

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionglycosyltransferase-like domain-containing protein 1glycosyltransferase-like 1mannosyltransferase candidatemannosyltransferase-like protein Xarho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A
Modification date2020032020200313
UniProtAcc.

Q9NRY4

Ensembl transtripts involved in fusion geneENST00000241391, ENST00000344850, 
ENST00000392867, ENST00000392869, 
ENST00000409214, ENST00000409298, 
ENST00000463875, ENST00000542155, 
ENST00000467352, 		ENST00000598548, 
ENST00000404338, 
Fusion gene scores* DoF score3 X 3 X 2=1814 X 8 X 8=896
# samples 314
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/896*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GTDC1 [Title/Abstract] AND ARHGAP35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGTDC1(144899449)-ARHGAP35(47491246), # samples:1
Anticipated loss of major functional domain due to fusion event.GTDC1-ARHGAP35 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GTDC1-ARHGAP35 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GTDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8683-01AGTDC1chr2

144899449

-ARHGAP35chr19

47491246

+


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Fusion Gene ORF analysis for GTDC1-ARHGAP35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000241391ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000344850ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000392867ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000392869ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000409214ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000409298ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000463875ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
5CDS-intronENST00000542155ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
Frame-shiftENST00000241391ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
Frame-shiftENST00000344850ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
Frame-shiftENST00000409214ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
Frame-shiftENST00000542155ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
In-frameENST00000392867ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
In-frameENST00000392869ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
In-frameENST00000409298ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
In-frameENST00000463875ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
intron-3CDSENST00000467352ENST00000404338GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+
intron-intronENST00000467352ENST00000598548GTDC1chr2

144899449

-ARHGAP35chr19

47491246

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392869GTDC1chr2144899449-ENST00000404338ARHGAP35chr1947491246+573767410672242391
ENST00000392867GTDC1chr2144899449-ENST00000404338ARHGAP35chr1947491246+583276911622337391
ENST00000409298GTDC1chr2144899449-ENST00000404338ARHGAP35chr1947491246+573467110642239391
ENST00000463875GTDC1chr2144899449-ENST00000404338ARHGAP35chr1947491246+55454828752050391

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392869ENST00000404338GTDC1chr2144899449-ARHGAP35chr1947491246+0.0103255270.9896745
ENST00000392867ENST00000404338GTDC1chr2144899449-ARHGAP35chr1947491246+0.0104277130.9895723
ENST00000409298ENST00000404338GTDC1chr2144899449-ARHGAP35chr1947491246+0.0103480290.989652
ENST00000463875ENST00000404338GTDC1chr2144899449-ARHGAP35chr1947491246+0.0107886020.98921144

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Fusion Genomic Features for GTDC1-ARHGAP35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GTDC1chr2144899448-ARHGAP35chr1947491245+2.88E-081
GTDC1chr2144899448-ARHGAP35chr1947491245+2.88E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GTDC1-ARHGAP35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:144899449/chr19:47491246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP35

Q9NRY4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP35chr2:144899449chr19:47491246ENST00000404338161440_149012751500.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP35chr2:144899449chr19:47491246ENST00000404338161249_143612751500.0DomainRho-GAP
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816270_32712751500.0DomainNote=FF 1
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816368_42212751500.0DomainNote=FF 2
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816429_48312751500.0DomainNote=FF 3
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816485_55012751500.0DomainNote=FF 4
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816592_76712751500.0DomainpG1 pseudoGTPase
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816783_94712751500.0DomainpG2 pseudoGTPase
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816201_20312751500.0Nucleotide bindingGTP
TgeneARHGAP35chr2:144899449chr19:47491246ENST0000040433816229_23112751500.0Nucleotide bindingGTP
TgeneARHGAP35chr2:144899449chr19:47491246ENST000004043381633_3712751500.0Nucleotide bindingGTP
TgeneARHGAP35chr2:144899449chr19:47491246ENST000004043381695_9712751500.0Nucleotide bindingGTP
TgeneARHGAP35chr2:144899449chr19:47491246ENST00000404338161213_123612751500.0RegionRequired for phospholipid binding and regulation of the substrate preference
TgeneARHGAP35chr2:144899449chr19:47491246ENST00000404338161_26612751500.0RegionHas GTPase activity%2C required for proper localization


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Fusion Gene Sequence for GTDC1-ARHGAP35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35151_35151_1_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000392867_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5832nt_BP=769nt
AGGTCTGGCTAGCTGTCCCTAACGTCATTTCCTGGTCTCAACTCTTTAAGACCCTGACATACTCTGAGATTGGAGTGAAGATTTCTGTGA
CATGCTGGGTATCTCTGCATTAGCCAGATTGGACATATGTAAAGGGACATCAGTATATCTGGATCATCAGATTGTGCTTCAAGAAGACCA
TAGGGAAGAACGCATTTTCATCTTGCTGCAAAAGTTGCAATAGAAGATCTGAAGGTTTGAATGGGCCAATGAGTATCCTCATCATTGAAG
CATTCTATGGAGGCTCCCATAAACAGCTGGTGGATCTTCTTCAAGAAGAGTTAGGAGACTGTGTCGTTTATACCCTTCCTGCAAAGAAAT
GGCATTGGAGAGCCCGGACATCTGCTTTATATTTCTCTCAGACCATTCCCATCAGTGAGCATTACAGGACCCTCTTTGCAAGTTCAGTGC
TTAACCTGACCGAACTGGCTGCCCTTCGGCCTGACCTTGGGAAACTGAAAAAGATTCTGTATTTTCACGAGAACCAGTTGATATATCCTG
TCAAGAAATGTCAGGAGAGGGATTTCCAATATGGATACAACCAAATTCTTTCATGCCTGGTGGCTGATGTGGTTGTATTCAACTCAGTTT
TTAATATGGAATCATTTCTCACTTCCATGGGAAAATTTATGAAGCTGATTCCTGATCACAGACCCAAGGATCTGGAAAGCATCATCAGAC
CCAAGTGCCAAGTTATTTACTTTCCCATCAGGTTTCCTGATGTGAGCAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAG
TCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGT
GCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGAC
CGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTA
AACAAGGTCAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTC
AGCACTATGGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGG
CCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGT
CAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTG
TGAGCCACCAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGA
CAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGT
ACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGT
TCCCTGGACCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCT
GGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCA
CCTTCCATCTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAG
GTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCAT
CCCCACCGTCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAAT
TAAAAAGGAAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGT
GGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGT
CTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGG
GCTGCCCCAGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGT
GTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAAT
CGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGG
TGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCC
ACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAA
GCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAA
ATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGG
AGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGA
AACACCTAACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGG
ATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGC
TGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTC
GAGGTTATGCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGG
CAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCC
GATTCCACAGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCT
CACAGAAGTACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGT
CCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGG
GACTAGAGGACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAAT
GGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTT
CTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGA
CGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCT
CTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCA
CGGCACACATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCC
GTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGT
CTTTGTCACGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTG
CTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACAC
ACACACACACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCC
CATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGG
CTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTG
AGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCG
GGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCAC
CTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATA
AAAAGAATCATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATT
TGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTT
GAGTTTCTGAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAG
TGAAGACCTGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATG
TTTGCTTAATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAG
GCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGG

>35151_35151_1_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000392867_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=391AA_BP=
MISALWTPSQPRAPTRQSLNSLSSSAPSSSTIGPSPSPPAPGPAPPLPWLPPSPSSLPRLSQVSRRPHSRLHPPPSPQCSHCFPPSFKPN
TRCEPPRPGATGEPVLSLTGWHLALNKTKSTGDRGRGKWLSPLPSQDLSGSTSQWYHRLGCQVPWAWRCRPELAWTHLRTELGRQWLQCP
PSVPWTTTPRSCSHQPPGASLCLYRAHGRDSALAFAGEEDALRFRVGLATPEENTSCWSVSSHLPSAHTPKVRVQPGWRPPWERVGHGSA
TTRYLLRALALQIRTTEDSFVPGPRECGTPRFIPTVPLHSLPETFPGKQRNTRRKNGKTLPVIKKEETTERKLQTSRFHSVPASAGREGG

--------------------------------------------------------------
>35151_35151_2_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000392869_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5737nt_BP=674nt
CAGGTATCTCTGCATTAGCCAGATTGGACATATGTAAAGGGACATCAGTATATCTGGATCATCAGATTGTGCTTCAAGAAGACCATAGGG
AAGAACGCATTTTCATCTTGCTGCAAAAGTTGCAATAGAAGATCTGAAGGTTTGAATGGGCCAATGAGTATCCTCATCATTGAAGCATTC
TATGGAGGCTCCCATAAACAGCTGGTGGATCTTCTTCAAGAAGAGTTAGGAGACTGTGTCGTTTATACCCTTCCTGCAAAGAAATGGCAT
TGGAGAGCCCGGACATCTGCTTTATATTTCTCTCAGACCATTCCCATCAGTGAGCATTACAGGACCCTCTTTGCAAGTTCAGTGCTTAAC
CTGACCGAACTGGCTGCCCTTCGGCCTGACCTTGGGAAACTGAAAAAGATTCTGTATTTTCACGAGAACCAGTTGATATATCCTGTCAAG
AAATGTCAGGAGAGGGATTTCCAATATGGATACAACCAAATTCTTTCATGCCTGGTGGCTGATGTGGTTGTATTCAACTCAGTTTTTAAT
ATGGAATCATTTCTCACTTCCATGGGAAAATTTATGAAGCTGATTCCTGATCACAGACCCAAGGATCTGGAAAGCATCATCAGACCCAAG
TGCCAAGTTATTTACTTTCCCATCAGGTTTCCTGATGTGAGCAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGA
GATGGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCAT
GAAGAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGA
GCAGAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAA
GGTCAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCAC
TATGGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCAT
CACCGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCC
GTCGCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGC
CACCAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAG
GCAGGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCT
GGGCCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCT
GGACCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCT
TTGCCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTC
CATCTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACC
TGCTGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCA
CCGTCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAA
AGGAAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGC
TGACCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGT
CGCTAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGC
CCCAGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTG
GGCGCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTT
CATCCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCC
TCGAAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGC
CCCAGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTG
ACACTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGG
ATCTGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACG
GGAGTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACAC
CTAACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGAT
GAATTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGG
TTGGCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGT
TATGCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAA
GCAGCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTC
CACAGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAG
AAGTACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAA
GGGAGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTA
GAGGACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCA
CTTGCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGA
AGGTGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGG
GGCAGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGAC
GGCTGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCA
CACATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCT
CTCCTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTG
TCACGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCT
CTTAGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACA
CACACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCC
TTTCCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGG
TCTGGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTG
TAACGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCC
GGTGGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGG
CCACTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAG
AATCATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAA
TAGTGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTT
TCTGAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAG
ACCTGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGC
TTAATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGA
GGCATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGG

>35151_35151_2_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000392869_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=391AA_BP=
MISALWTPSQPRAPTRQSLNSLSSSAPSSSTIGPSPSPPAPGPAPPLPWLPPSPSSLPRLSQVSRRPHSRLHPPPSPQCSHCFPPSFKPN
TRCEPPRPGATGEPVLSLTGWHLALNKTKSTGDRGRGKWLSPLPSQDLSGSTSQWYHRLGCQVPWAWRCRPELAWTHLRTELGRQWLQCP
PSVPWTTTPRSCSHQPPGASLCLYRAHGRDSALAFAGEEDALRFRVGLATPEENTSCWSVSSHLPSAHTPKVRVQPGWRPPWERVGHGSA
TTRYLLRALALQIRTTEDSFVPGPRECGTPRFIPTVPLHSLPETFPGKQRNTRRKNGKTLPVIKKEETTERKLQTSRFHSVPASAGREGG

--------------------------------------------------------------
>35151_35151_3_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000409298_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5734nt_BP=671nt
GTATCTCTGCATTAGCCAGATTGGACATATGTAAAGGGACATCAGTATATCTGGATCATCAGATTGTGCTTCAAGAAGACCATAGGGAAG
AACGCATTTTCATCTTGCTGCAAAAGTTGCAATAGAAGATCTGAAGGTTTGAATGGGCCAATGAGTATCCTCATCATTGAAGCATTCTAT
GGAGGCTCCCATAAACAGCTGGTGGATCTTCTTCAAGAAGAGTTAGGAGACTGTGTCGTTTATACCCTTCCTGCAAAGAAATGGCATTGG
AGAGCCCGGACATCTGCTTTATATTTCTCTCAGACCATTCCCATCAGTGAGCATTACAGGACCCTCTTTGCAAGTTCAGTGCTTAACCTG
ACCGAACTGGCTGCCCTTCGGCCTGACCTTGGGAAACTGAAAAAGATTCTGTATTTTCACGAGAACCAGTTGATATATCCTGTCAAGAAA
TGTCAGGAGAGGGATTTCCAATATGGATACAACCAAATTCTTTCATGCCTGGTGGCTGATGTGGTTGTATTCAACTCAGTTTTTAATATG
GAATCATTTCTCACTTCCATGGGAAAATTTATGAAGCTGATTCCTGATCACAGACCCAAGGATCTGGAAAGCATCATCAGACCCAAGTGC
CAAGTTATTTACTTTCCCATCAGGTTTCCTGATGTGAGCAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGAT
GGAGAGTCTGCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAA
GAGCTTTTTCTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCA
GAAGTTGCATGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGT
CAGCCACAACAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTAT
GGACGCCCTCACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCAC
CGAGCCCCCCGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTC
GCCCCCACAGTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCAC
CAAGACCTGGGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCA
GGGGCAAGTGGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGG
CCTGGCGCTGCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGA
CCACCACCCCACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTG
CCGGGGAGGAGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCAT
CTGCACACACCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGC
TGAGGGCGCTGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCG
TCCCACTCCACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGG
AAGAAACCACAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGA
CCCTCGTCTTTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGC
TAGATCCCCCGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCC
AGAACACAGTCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGC
GCTTGGTGGGGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCAT
CCCAGCCATGGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCG
AAGGGGCATCCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCC
AGGAAAAGCTCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACA
CTAGGCACCCCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATC
TGTGGTGTATTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGA
GTGGCCCTTCGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTA
ACCTTGCAAGTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAA
TTTTTGTCTCTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTG
GCAGAAACGTTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTAT
GCTCACCTGGTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCA
GCCCAGTCCCCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCAC
AGATGTATGTGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAG
TACCTGAAACTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGG
AGCCCCCATGCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAG
GACATCTCGGTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTT
GCATGGGAGCCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGG
TGTGTGCACAGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGC
AGCCACCCCTGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGC
TGAAGAGGGAAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACAC
ATTTACTCTGCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTC
CTGCCTCCACCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCA
CGGTGGACAGAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTT
AGGGAAAGGAGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACACAC
ACACACACACACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTT
CCTATGAGAAGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCT
GGTTGAGTCGCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAA
CGGGGGTGGGCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGT
GGGGGCGCGGCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCA
CTGCTGACCTGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAAT
CATGTTCCCTGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAG
TGCTGCTGCCAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCT
GAGAAAAAACAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACC
TGTATGTAAAGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTA
ATTTCCAGACTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGC
ATCTCTGACTGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGT

>35151_35151_3_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000409298_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=391AA_BP=
MISALWTPSQPRAPTRQSLNSLSSSAPSSSTIGPSPSPPAPGPAPPLPWLPPSPSSLPRLSQVSRRPHSRLHPPPSPQCSHCFPPSFKPN
TRCEPPRPGATGEPVLSLTGWHLALNKTKSTGDRGRGKWLSPLPSQDLSGSTSQWYHRLGCQVPWAWRCRPELAWTHLRTELGRQWLQCP
PSVPWTTTPRSCSHQPPGASLCLYRAHGRDSALAFAGEEDALRFRVGLATPEENTSCWSVSSHLPSAHTPKVRVQPGWRPPWERVGHGSA
TTRYLLRALALQIRTTEDSFVPGPRECGTPRFIPTVPLHSLPETFPGKQRNTRRKNGKTLPVIKKEETTERKLQTSRFHSVPASAGREGG

--------------------------------------------------------------
>35151_35151_4_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000463875_ARHGAP35_chr19_47491246_ENST00000404338_length(transcript)=5545nt_BP=482nt
GGGCACGGCGTCAGCGCGTCGCCGGCTGGGCCGCGCCGGTGGCCAGGAGGGAGAGACAAGGAGGAGGAGGAGGAGGAGGTATCTCTGCAT
TAGCCAGATTGGACATATGTAAAGGGACATCAGTATATCTGGATCATCAGGACCCTCTTTGCAAGTTCAGTGCTTAACCTGACCGAACTG
GCTGCCCTTCGGCCTGACCTTGGGAAACTGAAAAAGATTCTGTATTTTCACGAGAACCAGTTGATATATCCTGTCAAGAAATGTCAGGAG
AGGGATTTCCAATATGGATACAACCAAATTCTTTCATGCCTGGTGGCTGATGTGGTTGTATTCAACTCAGTTTTTAATATGGAATCATTT
CTCACTTCCATGGGAAAATTTATGAAGCTGATTCCTGATCACAGACCCAAGGATCTGGAAAGCATCATCAGACCCAAGTGCCAAGTTATT
TACTTTCCCATCAGGTTTCCTGATGTGAGCAGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCT
GCAGAGACAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTT
CTCAGAACTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCA
TGCCCTTAAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAA
CAACAAGGTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCT
CACAGCCACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCC
CGGCGCCAGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACA
GTCGCCTCCACCCACCCCCCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCACCAAGACCTG
GGGCGACAGGAGAACCGGTCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGT
GGCTCTCCCCATTACCTTCTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCT
GCAGACCTGAGCTGGCTTGGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGACCACCACCC
CACGTAGCTGCTCACACCAGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGG
AGGATGCTCTGAGATTCAGGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCATCTGCACACA
CCCCCAAGGTAAGGGTACAGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGCTGAGGGCGC
TGGCTCTGCAGATCAGAACAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCGTCCCACTCC
ACAGCCTTCCCGAAACATTCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGGAAGAAACCA
CAGAAAGAAAACTACAGACCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGACCCTCGTCT
TTGTGGCAGCAAAACCAGGATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGCTAGATCCCC
CGTTTTCCCAAGAAGAGGGTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCCAGAACACAG
TCCATTACGATAGAAACACTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGG
GGGGTTGGGGACAGCTGGAAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCATCCCAGCCAT
GGAGGCCACCAGCAGGAGTGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCAT
CCTTCCTGGTCTTCGCTGACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGC
TCTTCTCCTGGCCACCTCTGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACACTAGGCACC
CCCCAGGCGAGAGCTAGTGGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATCTGTGGTGTA
TTCCAGGGGGCCTGATGGACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTT
CGGCTCCCGAGCTCCCTCTGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTAACCTTGCAA
GTTTTACCGCCTTTTGAGGAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAATTTTTGTCT
CTTCTGGTGGAGCTGTGCCTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACG
TTCCCAAACTCCCCCAGCCCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTATGCTCACCTG
GTCAGCTCCTCACGTAATTGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCC
CCCTCACTGCTTGAGCTAACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCACAGATGTATG
TGCGGCCAGTGACTTCCCCAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAGTACCTGAAA
CTAGGTCTGGGGCACTCCCAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCAT
GCACAGGAAGCCACAGGGTTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAGGACATCTCG
GTCGTTTGAGGGGCATGGCCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTTGCATGGGAG
CCACAGAGGAGCGTCCCTGGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCAC
AGAGGGTGCTCATGGGACTCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGCAGCCACCCC
TGCCCAGCGAGAGCGCAGACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGCTGAAGAGGG
AAGACCCAAGGCTGGGTGGCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACACATTTACTCT
GCATTGTCCCCGTCTTTCCCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCA
CCGCCTTGGTTTTGCTTCCTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCACGGTGGACA
GAGGGTGACATCATAGGAGCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGG
AGGCCTGGGTCAAGCCAGCATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACACACACACACACA
CACACACAAAACTTCACAGCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGA
AGCCACTGCTTTGGGGGCGCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTC
GCTGCTTTCCCGAGGGCAGCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGG
GCTCCCTCCCTCGGAGGACATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCG
GCCGCGGTGCGGTCGGTGCAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCACTGCTGACC
TGGGCTGGCCTCCCCCAGCCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAATCATGTTCCC
TGTGTACATTTAAGAAAAAAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAGTGCTGCTGC
CAGCTTATTTTTCTGGTACTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCTGAGAAAAAA
CAAAACATATTAATGGTATTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAA
AGAAAGTATAACAATTATTTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGA
CTTTTTTTTAAAAACACATCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGCATCTCTGAC
TGAGGTGTTTTTGTTTGGTTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGTAAAAAACAA

>35151_35151_4_GTDC1-ARHGAP35_GTDC1_chr2_144899449_ENST00000463875_ARHGAP35_chr19_47491246_ENST00000404338_length(amino acids)=391AA_BP=
MISALWTPSQPRAPTRQSLNSLSSSAPSSSTIGPSPSPPAPGPAPPLPWLPPSPSSLPRLSQVSRRPHSRLHPPPSPQCSHCFPPSFKPN
TRCEPPRPGATGEPVLSLTGWHLALNKTKSTGDRGRGKWLSPLPSQDLSGSTSQWYHRLGCQVPWAWRCRPELAWTHLRTELGRQWLQCP
PSVPWTTTPRSCSHQPPGASLCLYRAHGRDSALAFAGEEDALRFRVGLATPEENTSCWSVSSHLPSAHTPKVRVQPGWRPPWERVGHGSA
TTRYLLRALALQIRTTEDSFVPGPRECGTPRFIPTVPLHSLPETFPGKQRNTRRKNGKTLPVIKKEETTERKLQTSRFHSVPASAGREGG

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Fusion Gene PPI Analysis for GTDC1-ARHGAP35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GTDC1-ARHGAP35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GTDC1-ARHGAP35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource