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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GTF2F2-GPALPP1 (FusionGDB2 ID:35191)

Fusion Gene Summary for GTF2F2-GPALPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF2F2-GPALPP1
Fusion gene ID: 35191
HgeneTgene
Gene symbol

GTF2F2

GPALPP1

Gene ID

2963

55425

Gene namegeneral transcription factor IIF subunit 2GPALPP motifs containing 1
SynonymsBTF4|RAP30|TF2F2|TFIIFAD029|KIAA1704|LSR7|bA245H20.2
Cytomap

13q14.12-q14.13

13q14.12

Type of geneprotein-codingprotein-coding
Descriptiongeneral transcription factor IIF subunit 2ATP-dependent helicase GTF2F2TFIIF-betageneral transcription factor IIF 30 kDa subunitgeneral transcription factor IIF, polypeptide 2, 30kDatranscription initiation factor IIF subunit betatranscription initiGPALPP motifs-containing protein 1lipopolysaccharide specific response-7 proteinlipopolysaccharide-specific response protein 7
Modification date2020031320200313
UniProtAcc

P13984

Q8IXQ4

Ensembl transtripts involved in fusion geneENST00000494087, ENST00000340473, 
ENST00000361121, ENST00000379151, 
ENST00000357537, ENST00000473119, 
Fusion gene scores* DoF score11 X 7 X 7=5394 X 6 X 3=72
# samples 136
** MAII scorelog2(13/539*10)=-2.05177364972405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GTF2F2 [Title/Abstract] AND GPALPP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGTF2F2(45827105)-GPALPP1(45589087), # samples:2
GTF2F2(45725966)-GPALPP1(45578440), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GTF2F2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPALPP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AADA-01AGTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
ChimerDB4LIHCTCGA-DD-AADAGTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
ChimerDB4LUSCTCGA-56-A4BX-01AGTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
ChimerDB4LUSCTCGA-56-A4BXGTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
ChiTaRS5.0N/AEC539321GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-


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Fusion Gene ORF analysis for GTF2F2-GPALPP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000494087ENST00000361121GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
3UTR-3CDSENST00000494087ENST00000379151GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
3UTR-5UTRENST00000494087ENST00000357537GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
3UTR-intronENST00000494087ENST00000473119GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
5CDS-5UTRENST00000340473ENST00000357537GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
5CDS-intronENST00000340473ENST00000357537GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
5CDS-intronENST00000340473ENST00000473119GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
5CDS-intronENST00000340473ENST00000473119GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
In-frameENST00000340473ENST00000361121GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
In-frameENST00000340473ENST00000361121GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
In-frameENST00000340473ENST00000379151GTF2F2chr13

45827105

+GPALPP1chr13

45589087

+
In-frameENST00000340473ENST00000379151GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
intron-3CDSENST00000494087ENST00000361121GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
intron-3CDSENST00000494087ENST00000379151GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
intron-intronENST00000340473ENST00000357537GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000340473ENST00000361121GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000340473ENST00000379151GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000340473ENST00000473119GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000494087ENST00000357537GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
intron-intronENST00000494087ENST00000357537GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000494087ENST00000361121GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000494087ENST00000379151GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-
intron-intronENST00000494087ENST00000473119GTF2F2chr13

45725966

+GPALPP1chr13

45578440

+
intron-intronENST00000494087ENST00000473119GTF2F2chr13

45833537

-GPALPP1chr13

45565556

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340473GTF2F2chr1345827105+ENST00000379151GPALPP1chr1345589087+1509627601241393
ENST00000340473GTF2F2chr1345827105+ENST00000361121GPALPP1chr1345589087+4209627601241393
ENST00000340473GTF2F2chr1345725966+ENST00000379151GPALPP1chr1345578440+1647445601379439
ENST00000340473GTF2F2chr1345725966+ENST00000361121GPALPP1chr1345578440+4347445601379439

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340473ENST00000379151GTF2F2chr1345827105+GPALPP1chr1345589087+0.0008129670.99918705
ENST00000340473ENST00000361121GTF2F2chr1345827105+GPALPP1chr1345589087+0.0002295520.99977046
ENST00000340473ENST00000379151GTF2F2chr1345725966+GPALPP1chr1345578440+0.0007680160.99923193
ENST00000340473ENST00000361121GTF2F2chr1345725966+GPALPP1chr1345578440+0.0002442170.9997558

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Fusion Genomic Features for GTF2F2-GPALPP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GTF2F2chr1345725966+GPALPP1chr1345578439+2.07E-050.99997926
GTF2F2chr1345725966+GPALPP1chr1345578439+2.07E-050.99997926
GTF2F2chr1345827105+GPALPP1chr1345589086+1.55E-060.99999845
GTF2F2chr1345827105+GPALPP1chr1345589086+1.55E-060.99999845
GTF2F2chr1345725966+GPALPP1chr1345578439+2.07E-050.99997926
GTF2F2chr1345725966+GPALPP1chr1345578439+2.07E-050.99997926
GTF2F2chr1345827105+GPALPP1chr1345589086+1.55E-060.99999845
GTF2F2chr1345827105+GPALPP1chr1345589086+1.55E-060.99999845

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GTF2F2-GPALPP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:45827105/chr13:45589087)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GTF2F2

P13984

GPALPP1

Q8IXQ4

FUNCTION: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. {ECO:0000269|PubMed:2477704}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGTF2F2chr13:45725966chr13:45578440ENST00000340473+4836_43101250.0Nucleotide bindingATP
HgeneGTF2F2chr13:45827105chr13:45589087ENST00000340473+6836_43162250.0Nucleotide bindingATP
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003575370841_490251.0Compositional biasNote=Poly-Ser
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003575370881_880251.0Compositional biasNote=Poly-Asp
TgeneGPALPP1chr13:45725966chr13:45578440ENST0000036112101241_49291182.3333333333333Compositional biasNote=Poly-Ser
TgeneGPALPP1chr13:45725966chr13:45578440ENST0000036112101281_88291182.3333333333333Compositional biasNote=Poly-Asp
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003791510841_4929341.0Compositional biasNote=Poly-Ser
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003791510881_8829341.0Compositional biasNote=Poly-Asp
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003575372841_490251.0Compositional biasNote=Poly-Ser
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003575372881_880251.0Compositional biasNote=Poly-Asp
TgeneGPALPP1chr13:45725966chr13:45578440ENST0000035753708112_1170251.0MotifNote=GPALPP motif 4
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003575370832_370251.0MotifNote=GPALPP motif 2
TgeneGPALPP1chr13:45725966chr13:45578440ENST00000357537087_120251.0MotifNote=GPALPP motif 1
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003575370892_970251.0MotifNote=GPALPP motif 3
TgeneGPALPP1chr13:45725966chr13:45578440ENST00000361121012112_117291182.3333333333333MotifNote=GPALPP motif 4
TgeneGPALPP1chr13:45725966chr13:45578440ENST0000036112101232_37291182.3333333333333MotifNote=GPALPP motif 2
TgeneGPALPP1chr13:45725966chr13:45578440ENST0000036112101292_97291182.3333333333333MotifNote=GPALPP motif 3
TgeneGPALPP1chr13:45725966chr13:45578440ENST0000037915108112_11729341.0MotifNote=GPALPP motif 4
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003791510832_3729341.0MotifNote=GPALPP motif 2
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003791510892_9729341.0MotifNote=GPALPP motif 3
TgeneGPALPP1chr13:45827105chr13:45589087ENST0000035753728112_1170251.0MotifNote=GPALPP motif 4
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003575372832_370251.0MotifNote=GPALPP motif 2
TgeneGPALPP1chr13:45827105chr13:45589087ENST00000357537287_120251.0MotifNote=GPALPP motif 1
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003575372892_970251.0MotifNote=GPALPP motif 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPALPP1chr13:45827105chr13:45589087ENST0000036112131241_491361182.3333333333333Compositional biasNote=Poly-Ser
TgeneGPALPP1chr13:45827105chr13:45589087ENST0000036112131281_881361182.3333333333333Compositional biasNote=Poly-Asp
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003791513841_49136341.0Compositional biasNote=Poly-Ser
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003791513881_88136341.0Compositional biasNote=Poly-Asp
TgeneGPALPP1chr13:45725966chr13:45578440ENST000003611210127_12291182.3333333333333MotifNote=GPALPP motif 1
TgeneGPALPP1chr13:45725966chr13:45578440ENST00000379151087_1229341.0MotifNote=GPALPP motif 1
TgeneGPALPP1chr13:45827105chr13:45589087ENST00000361121312112_1171361182.3333333333333MotifNote=GPALPP motif 4
TgeneGPALPP1chr13:45827105chr13:45589087ENST0000036112131232_371361182.3333333333333MotifNote=GPALPP motif 2
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003611213127_121361182.3333333333333MotifNote=GPALPP motif 1
TgeneGPALPP1chr13:45827105chr13:45589087ENST0000036112131292_971361182.3333333333333MotifNote=GPALPP motif 3
TgeneGPALPP1chr13:45827105chr13:45589087ENST0000037915138112_117136341.0MotifNote=GPALPP motif 4
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003791513832_37136341.0MotifNote=GPALPP motif 2
TgeneGPALPP1chr13:45827105chr13:45589087ENST00000379151387_12136341.0MotifNote=GPALPP motif 1
TgeneGPALPP1chr13:45827105chr13:45589087ENST000003791513892_97136341.0MotifNote=GPALPP motif 3


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Fusion Gene Sequence for GTF2F2-GPALPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35191_35191_1_GTF2F2-GPALPP1_GTF2F2_chr13_45725966_ENST00000340473_GPALPP1_chr13_45578440_ENST00000361121_length(transcript)=4347nt_BP=445nt
TTCCCAGTGTTCTGGCAGGTAAGGAACGCCGGCTCTTCGCCTCTCAGCGCGGCTTGTCCTTTGTTCCGGACGCCCGCTCCTCAGCCCTGC
GGCTCCTGGGGTCGCTGCTGCATCCCGCACGCCTCCACCGGCTGCAGACCCATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAA
CAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAATGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTG
CGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAGGATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCT
TCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGACAGACATTAACAGTATTTACTGAGAGCTCATCAGTTGCA
GGACCAGCTCTGCCCCCTAATTATAAAAGCAGTAGTTCAGATTCATCAGACAGCGATGAAGACAGTAGTTCTTTGTACGAAGAAGGAAAT
CAAGAATCTGAAGAAGATGACAGTGGTCCAACTGCAAGAAAACAGAGGAAAAATCAGGATGATGACGATGATGATGATGATGGGTTTTTT
GGACCAGCCCTTCCTCCTGGATTTAAAAAGCAGGATGATTCTCCTCCAAGGCCCATAATAGGTCCTGCATTGCCACCTGGTTTCATTAAA
TCTACACAGAAAAGTGACAAGGGCAGAGATGATCCAGGACAACAGGAAACAGACAGCAGTGAAGATGAGGATATTATTGGACCAATGCCT
GCAAAAGGACCAGTTAACTATAATGTAACGACAGAGTTTGAAAAAAGGGCCCAGAGAATGAAAGAAAAACTGACCAAAGGAGATGATGAT
TCATCTAAACCCATTGTAAGAGAGTCATGGATGACTGAACTTCCTCCAGAAATGAAAGACTTTGGTCTTGGGCCAAGGACTTTTAAGAGA
AGAGCTGATGACACATCTGGAGATCGATCAATCTGGACAGATACTCCAGCTGATAGGGAAAGGAAAGCTAAGGAAACACAAGAAGCAAGG
AAGTCATCCAGTAAGAAAGATGAAGAACATATATTATCAGGAAGAGATAAGAGACTGGCTGAGCAGGTATCTTCATACAATGAATCAAAA
AGATCAGAATCTCTTATGGACATACATCATAAAAAGTTAAAGAGTAAGGCTGCTGAAGACAAAAATAAGCCTCAAGAGAGAATACCATTT
GACCGTGATAAAGATCTCAAGGTTAATCGGTTTGATGAAGCTCAGAAAAAAGCCCTAATAAAAAAATCTAGAGAACTAAACACCAGATTT
TCACACGGCAAAGGCAATATGTTTTTATAAGGGGATTTCCCTGTGCAATGAAGAAAAGTTGAAGAATACTCTTTGTCCATCTTTATTTCT
TTGTTTTTGGCTTCTTAAGATTAGAGATTACTTTAATCTTAAAAAACATACAAATTTACCTTGTTCTGTATGTCCTTTTAAGGTCATGTG
GAAACATAAAACGAATGTTTTTTATGTAGAACAGAATATTCTATGTGCCTTTAGCTTCTGTGGAAGTATGGGGAATTATGGGCTTTTCTT
CAAATAATTATTTTAAGAGGCTTCCATTCCCCCTGATTTTTGTGGTGTCTCACAAGTACCCTCTAAGGTCTGGTCAGGACTGACCACCAA
ATCTCTACCACAGCCTGGACCTCCTTGTGAAATATACCTAACCTGCCCTAGAGTCAGTGTGTCAAGTCCTTACTGTAAATCCATGACTTT
GAAATTTGTTGTTTTTTCCCTTTAAACTGCAGCCAGTGAATACAAATTTACTTGAAAATAGAGGGTATGGGGTTTTGCCTGTTTTGTAAT
CAGTTTGCTTGTTTTAGCACTCAGGGCTTTTTATTTGTTATTTAATTTTTTAATTGTTTTTAAGTCAGAAAGATCTCTGGGTTATCTCAT
GTGCTAAGGAAAAACTATTTTGCTTTTTCCAACTTTAATAGTTAGTATTTCTAGGGGAGGCAATCAAGATAAGATATGCCATTAACTGTT
AGCATTGTGAAATCTGTAAGACTCAATCTCTGATCTCAACCAAAGCTTTCTGAGTCCTGGAACTTTGCTTTGGGACAACTTTACTTTACC
CATTTATATGCTGTACTTAACAGTTTGTAGCTAATTTATGGGGTCATATCTTTTTTTTAGCTAATTTACGGGGGTCATATCAGTCATGAA
TAGCCTTTTTTAAAAATTTAATAATCCCTGAATACAAAAATGGAAATGGAAAATTTATAATCATAACCCCCCTAATTGGGAGTATTATAA
GTTTGTAATGCTTTAAGCACTGCCTCTTAAGATGATAAATTTATAAGATGAGAAATTCTATTTAAACTATTAAACTATTGTTAAATAAAT
GCCAATTCTATAAGTTATATTTTCTTGCAGATTAATCCCAATTGTTCCACTAGTATTCTAGTTTTGATGAGACACAAATTTTTGTTGTTG
TTTATTTTTGTTTTTTTGAGAGATGGAGTCTTGCTCTGTCACCCAGGCTGGAGTAGAGTGGCGTGATCTCAGCTTACTGCAACCTCCGCC
TCCTGGGTTCAAGCGATTCTCCTGCCTCAGTGTCCCAAGTAGCTGGGACTACAGGCGTGCACCACCATGCCTGGCCAAGACACAAATTTT
TAATGGAAAAATATTCTGATTCCCAGTTCATGTAAGCTTTATGAAAATTGAGTATATTGTTTATATGATGGTACAAATTATTCTTCCTCT
AATAATAGCAGTACAGTATATTTTTTCCATAGCATCAGTGTAAACCATAGCAAACTAAAGGAGCATTGCTATTAAAAAGATGAATTAGCT
GGGCGCAGTGGCTCATACCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGATAATTGCTTGAACCTAGGAGGCGGAGGTTGCAGTGAG
CCAAGATCACACCATTGCATTCCAGCCTGGGCAACAAGAGTGAAACTCCATCTCTAAATAAATAAGTAAATAAATAGATGAATTTTTCTC
CTAAGCAAATTGAAAAAGCTTCTTGTGTACTCAAAATTGAACAGAGCTACCTTTTGACTAAAAATGTCATTTTTAATGAGCAGTATTTTC
TGAACACAAAATTTTGTACAAGAGTGTCTCCATTGCATTAATTTAATTTTGTTATAATTTTTTCCCAATGAAAGGAAAAAAGTATTTTGT
AGCTCCTCTTCCTTATGTAAATTCTTAACATATATTTTTGAGAAATTTGCATTTTTTAAAGTAAAATTGTTATCTTTGGATACTTACTTT
TCTTTGTTTTCCTCATTTAAAGAGAATAGGGATATTTCTGTATTATATATTTACTGTTTCATCCCTCACCTTTGGAGTGACCATGACCTT
GGCATGAAGGAGAGAAACCTCTGCTTTCCGCCTATTGCTTCCAGGAGTTACTACCTTACTGGCCTTGGAGATAATGCTCTTTTGTGCCAA
CCTGAGGATAATTTTAACAAAATGTAAGGCCAGTTTCAGAGGTTGTTTTGCCCCACAGAGAGACTAATCCCAATACAAGAATATTGACAA
CAAAAGGACAAAGTAGTTATTGCACAGGACGGAAAGGTGTCTTTATTTCATCCCCTCCCCACTTCCAAAGATGCAAAAGGCCTAATTGAA
TCAAGTCTCCTTTCCATCTGGCAGGAGACATTTTAATAAGGACTTTTTAATTTCCTACATTTCTTGGCCAAGTGTCATAGGAATGTGGCC
TCTTTTGAAATTTAAAAATGAAGAAGAAAAAAAGAGCAACACTAAGTTAATATAATGGAGCAGATACTTTTAATGTTCTTACCATTGAAT
ATGCCATTTAAGTTTGTTATACTTGAAATTATATGATTTTTGTCCAGCTCTCTAAATTGTCATCTCCAATAGATTTAGATGCTTCAAATA
GTAACCACATTACTGTGATAGGTATTATTAGAAAAAAGTTATTTCTTGAGTTACACCTAAGAGGAAGAAGTAACATGATGGAAAGTGGTT
GGAGATAGCACCCAATTAACATCGACAGCCAAGTCTTCTATTTCAGAATATTGATTTATTTCGCTTTGGCTTTTGATGCCATCATGAGAT
TTAAGTCTGCAGTTTCAAAAGCTCATGCTACTTAGATGATTTTTGCAGCTTAAAAAATTGCTTGTGACTGCAGTATGTACACAGTTAAAA
AGCTGTTCACTGCCCCTTTCAACCTTTTCATTTTGAGCTTTACTAAGAGAATGCTTTTAGGAACAGAATTCCTAAAGTGTAATTTTTTAT

>35191_35191_1_GTF2F2-GPALPP1_GTF2F2_chr13_45725966_ENST00000340473_GPALPP1_chr13_45578440_ENST00000361121_length(amino acids)=439AA_BP=126
MFRTPAPQPCGSWGRCCIPHASTGCRPMAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLA
NIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSVAGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDSGPTARKQRKNQD
DDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRM
KEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTSGDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLA

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>35191_35191_2_GTF2F2-GPALPP1_GTF2F2_chr13_45725966_ENST00000340473_GPALPP1_chr13_45578440_ENST00000379151_length(transcript)=1647nt_BP=445nt
TTCCCAGTGTTCTGGCAGGTAAGGAACGCCGGCTCTTCGCCTCTCAGCGCGGCTTGTCCTTTGTTCCGGACGCCCGCTCCTCAGCCCTGC
GGCTCCTGGGGTCGCTGCTGCATCCCGCACGCCTCCACCGGCTGCAGACCCATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAA
CAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAATGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTG
CGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAGGATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCT
TCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGACAGACATTAACAGTATTTACTGAGAGCTCATCAGTTGCA
GGACCAGCTCTGCCCCCTAATTATAAAAGCAGTAGTTCAGATTCATCAGACAGCGATGAAGACAGTAGTTCTTTGTACGAAGAAGGAAAT
CAAGAATCTGAAGAAGATGACAGTGGTCCAACTGCAAGAAAACAGAGGAAAAATCAGGATGATGACGATGATGATGATGATGGGTTTTTT
GGACCAGCCCTTCCTCCTGGATTTAAAAAGCAGGATGATTCTCCTCCAAGGCCCATAATAGGTCCTGCATTGCCACCTGGTTTCATTAAA
TCTACACAGAAAAGTGACAAGGGCAGAGATGATCCAGGACAACAGGAAACAGACAGCAGTGAAGATGAGGATATTATTGGACCAATGCCT
GCAAAAGGACCAGTTAACTATAATGTAACGACAGAGTTTGAAAAAAGGGCCCAGAGAATGAAAGAAAAACTGACCAAAGGAGATGATGAT
TCATCTAAACCCATTGTAAGAGAGTCATGGATGACTGAACTTCCTCCAGAAATGAAAGACTTTGGTCTTGGGCCAAGGACTTTTAAGAGA
AGAGCTGATGACACATCTGGAGATCGATCAATCTGGACAGATACTCCAGCTGATAGGGAAAGGAAAGCTAAGGAAACACAAGAAGCAAGG
AAGTCATCCAGTAAGAAAGATGAAGAACATATATTATCAGGAAGAGATAAGAGACTGGCTGAGCAGGTATCTTCATACAATGAATCAAAA
AGATCAGAATCTCTTATGGACATACATCATAAAAAGTTAAAGAGTAAGGCTGCTGAAGACAAAAATAAGCCTCAAGAGAGAATACCATTT
GACCGTGATAAAGATCTCAAGGTTAATCGGTTTGATGAAGCTCAGAAAAAAGCCCTAATAAAAAAATCTAGAGAACTAAACACCAGATTT
TCACACGGCAAAGGCAATATGTTTTTATAAGTAAGTATATTTCAGTGAGGTATATTTTAATACTGATCAATGTGAACTTTTCTAAATACT
CTATTGTCTTTAATAATTGTGCTGAAATCTATTTCCTTTTATAATAGATTAAAAATTTTATATTTTTATAAGTAAACAGTGATTTTTGAA
AAGTCAGCCTTGTGGGATGAAAAATATGTCTTACTGGAAAAATCCCTCATAATAACCTAATAGGGCATTGCTATTAAAAATGCTAAAATA

>35191_35191_2_GTF2F2-GPALPP1_GTF2F2_chr13_45725966_ENST00000340473_GPALPP1_chr13_45578440_ENST00000379151_length(amino acids)=439AA_BP=126
MFRTPAPQPCGSWGRCCIPHASTGCRPMAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLA
NIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSVAGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDSGPTARKQRKNQD
DDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRM
KEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTSGDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLA

--------------------------------------------------------------
>35191_35191_3_GTF2F2-GPALPP1_GTF2F2_chr13_45827105_ENST00000340473_GPALPP1_chr13_45589087_ENST00000361121_length(transcript)=4209nt_BP=627nt
TTCCCAGTGTTCTGGCAGGTAAGGAACGCCGGCTCTTCGCCTCTCAGCGCGGCTTGTCCTTTGTTCCGGACGCCCGCTCCTCAGCCCTGC
GGCTCCTGGGGTCGCTGCTGCATCCCGCACGCCTCCACCGGCTGCAGACCCATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAA
CAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAATGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTG
CGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAGGATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCT
TCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGACAGACATTAACAGTATTTACTGAGAGCTCATCAGATAAG
CTGTCATTGGAAGGAATAGTGGTACAAAGAGCTGAATGCCGACCAGCTGCCAGTGAAAACTACATGCGATTAAAAAGATTGCAAATAGAA
GAGTCTTCCAAACCAGTGAGGCTATCACAACAGCTGGACAAAGTTGTAACAACCAATTACAAACCTGTTGCTAATCATCAATACAATGAA
ACAGACAGCAGTGAAGATGAGGATATTATTGGACCAATGCCTGCAAAAGGACCAGTTAACTATAATGTAACGACAGAGTTTGAAAAAAGG
GCCCAGAGAATGAAAGAAAAACTGACCAAAGGAGATGATGATTCATCTAAACCCATTGTAAGAGAGTCATGGATGACTGAACTTCCTCCA
GAAATGAAAGACTTTGGTCTTGGGCCAAGGACTTTTAAGAGAAGAGCTGATGACACATCTGGAGATCGATCAATCTGGACAGATACTCCA
GCTGATAGGGAAAGGAAAGCTAAGGAAACACAAGAAGCAAGGAAGTCATCCAGTAAGAAAGATGAAGAACATATATTATCAGGAAGAGAT
AAGAGACTGGCTGAGCAGGTATCTTCATACAATGAATCAAAAAGATCAGAATCTCTTATGGACATACATCATAAAAAGTTAAAGAGTAAG
GCTGCTGAAGACAAAAATAAGCCTCAAGAGAGAATACCATTTGACCGTGATAAAGATCTCAAGGTTAATCGGTTTGATGAAGCTCAGAAA
AAAGCCCTAATAAAAAAATCTAGAGAACTAAACACCAGATTTTCACACGGCAAAGGCAATATGTTTTTATAAGGGGATTTCCCTGTGCAA
TGAAGAAAAGTTGAAGAATACTCTTTGTCCATCTTTATTTCTTTGTTTTTGGCTTCTTAAGATTAGAGATTACTTTAATCTTAAAAAACA
TACAAATTTACCTTGTTCTGTATGTCCTTTTAAGGTCATGTGGAAACATAAAACGAATGTTTTTTATGTAGAACAGAATATTCTATGTGC
CTTTAGCTTCTGTGGAAGTATGGGGAATTATGGGCTTTTCTTCAAATAATTATTTTAAGAGGCTTCCATTCCCCCTGATTTTTGTGGTGT
CTCACAAGTACCCTCTAAGGTCTGGTCAGGACTGACCACCAAATCTCTACCACAGCCTGGACCTCCTTGTGAAATATACCTAACCTGCCC
TAGAGTCAGTGTGTCAAGTCCTTACTGTAAATCCATGACTTTGAAATTTGTTGTTTTTTCCCTTTAAACTGCAGCCAGTGAATACAAATT
TACTTGAAAATAGAGGGTATGGGGTTTTGCCTGTTTTGTAATCAGTTTGCTTGTTTTAGCACTCAGGGCTTTTTATTTGTTATTTAATTT
TTTAATTGTTTTTAAGTCAGAAAGATCTCTGGGTTATCTCATGTGCTAAGGAAAAACTATTTTGCTTTTTCCAACTTTAATAGTTAGTAT
TTCTAGGGGAGGCAATCAAGATAAGATATGCCATTAACTGTTAGCATTGTGAAATCTGTAAGACTCAATCTCTGATCTCAACCAAAGCTT
TCTGAGTCCTGGAACTTTGCTTTGGGACAACTTTACTTTACCCATTTATATGCTGTACTTAACAGTTTGTAGCTAATTTATGGGGTCATA
TCTTTTTTTTAGCTAATTTACGGGGGTCATATCAGTCATGAATAGCCTTTTTTAAAAATTTAATAATCCCTGAATACAAAAATGGAAATG
GAAAATTTATAATCATAACCCCCCTAATTGGGAGTATTATAAGTTTGTAATGCTTTAAGCACTGCCTCTTAAGATGATAAATTTATAAGA
TGAGAAATTCTATTTAAACTATTAAACTATTGTTAAATAAATGCCAATTCTATAAGTTATATTTTCTTGCAGATTAATCCCAATTGTTCC
ACTAGTATTCTAGTTTTGATGAGACACAAATTTTTGTTGTTGTTTATTTTTGTTTTTTTGAGAGATGGAGTCTTGCTCTGTCACCCAGGC
TGGAGTAGAGTGGCGTGATCTCAGCTTACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGTGTCCCAAGTAGCTGGGA
CTACAGGCGTGCACCACCATGCCTGGCCAAGACACAAATTTTTAATGGAAAAATATTCTGATTCCCAGTTCATGTAAGCTTTATGAAAAT
TGAGTATATTGTTTATATGATGGTACAAATTATTCTTCCTCTAATAATAGCAGTACAGTATATTTTTTCCATAGCATCAGTGTAAACCAT
AGCAAACTAAAGGAGCATTGCTATTAAAAAGATGAATTAGCTGGGCGCAGTGGCTCATACCTGTAATCCCAGCTACTCAGGAGGCTGAAG
CAGGATAATTGCTTGAACCTAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACACCATTGCATTCCAGCCTGGGCAACAAGAGTGAAACTC
CATCTCTAAATAAATAAGTAAATAAATAGATGAATTTTTCTCCTAAGCAAATTGAAAAAGCTTCTTGTGTACTCAAAATTGAACAGAGCT
ACCTTTTGACTAAAAATGTCATTTTTAATGAGCAGTATTTTCTGAACACAAAATTTTGTACAAGAGTGTCTCCATTGCATTAATTTAATT
TTGTTATAATTTTTTCCCAATGAAAGGAAAAAAGTATTTTGTAGCTCCTCTTCCTTATGTAAATTCTTAACATATATTTTTGAGAAATTT
GCATTTTTTAAAGTAAAATTGTTATCTTTGGATACTTACTTTTCTTTGTTTTCCTCATTTAAAGAGAATAGGGATATTTCTGTATTATAT
ATTTACTGTTTCATCCCTCACCTTTGGAGTGACCATGACCTTGGCATGAAGGAGAGAAACCTCTGCTTTCCGCCTATTGCTTCCAGGAGT
TACTACCTTACTGGCCTTGGAGATAATGCTCTTTTGTGCCAACCTGAGGATAATTTTAACAAAATGTAAGGCCAGTTTCAGAGGTTGTTT
TGCCCCACAGAGAGACTAATCCCAATACAAGAATATTGACAACAAAAGGACAAAGTAGTTATTGCACAGGACGGAAAGGTGTCTTTATTT
CATCCCCTCCCCACTTCCAAAGATGCAAAAGGCCTAATTGAATCAAGTCTCCTTTCCATCTGGCAGGAGACATTTTAATAAGGACTTTTT
AATTTCCTACATTTCTTGGCCAAGTGTCATAGGAATGTGGCCTCTTTTGAAATTTAAAAATGAAGAAGAAAAAAAGAGCAACACTAAGTT
AATATAATGGAGCAGATACTTTTAATGTTCTTACCATTGAATATGCCATTTAAGTTTGTTATACTTGAAATTATATGATTTTTGTCCAGC
TCTCTAAATTGTCATCTCCAATAGATTTAGATGCTTCAAATAGTAACCACATTACTGTGATAGGTATTATTAGAAAAAAGTTATTTCTTG
AGTTACACCTAAGAGGAAGAAGTAACATGATGGAAAGTGGTTGGAGATAGCACCCAATTAACATCGACAGCCAAGTCTTCTATTTCAGAA
TATTGATTTATTTCGCTTTGGCTTTTGATGCCATCATGAGATTTAAGTCTGCAGTTTCAAAAGCTCATGCTACTTAGATGATTTTTGCAG
CTTAAAAAATTGCTTGTGACTGCAGTATGTACACAGTTAAAAAGCTGTTCACTGCCCCTTTCAACCTTTTCATTTTGAGCTTTACTAAGA

>35191_35191_3_GTF2F2-GPALPP1_GTF2F2_chr13_45827105_ENST00000340473_GPALPP1_chr13_45589087_ENST00000361121_length(amino acids)=393AA_BP=189
MFRTPAPQPCGSWGRCCIPHASTGCRPMAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLA
NIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNY
KPVANHQYNETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTS
GDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDL

--------------------------------------------------------------
>35191_35191_4_GTF2F2-GPALPP1_GTF2F2_chr13_45827105_ENST00000340473_GPALPP1_chr13_45589087_ENST00000379151_length(transcript)=1509nt_BP=627nt
TTCCCAGTGTTCTGGCAGGTAAGGAACGCCGGCTCTTCGCCTCTCAGCGCGGCTTGTCCTTTGTTCCGGACGCCCGCTCCTCAGCCCTGC
GGCTCCTGGGGTCGCTGCTGCATCCCGCACGCCTCCACCGGCTGCAGACCCATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAA
CAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAATGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTG
CGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAGGATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCT
TCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGACAGACATTAACAGTATTTACTGAGAGCTCATCAGATAAG
CTGTCATTGGAAGGAATAGTGGTACAAAGAGCTGAATGCCGACCAGCTGCCAGTGAAAACTACATGCGATTAAAAAGATTGCAAATAGAA
GAGTCTTCCAAACCAGTGAGGCTATCACAACAGCTGGACAAAGTTGTAACAACCAATTACAAACCTGTTGCTAATCATCAATACAATGAA
ACAGACAGCAGTGAAGATGAGGATATTATTGGACCAATGCCTGCAAAAGGACCAGTTAACTATAATGTAACGACAGAGTTTGAAAAAAGG
GCCCAGAGAATGAAAGAAAAACTGACCAAAGGAGATGATGATTCATCTAAACCCATTGTAAGAGAGTCATGGATGACTGAACTTCCTCCA
GAAATGAAAGACTTTGGTCTTGGGCCAAGGACTTTTAAGAGAAGAGCTGATGACACATCTGGAGATCGATCAATCTGGACAGATACTCCA
GCTGATAGGGAAAGGAAAGCTAAGGAAACACAAGAAGCAAGGAAGTCATCCAGTAAGAAAGATGAAGAACATATATTATCAGGAAGAGAT
AAGAGACTGGCTGAGCAGGTATCTTCATACAATGAATCAAAAAGATCAGAATCTCTTATGGACATACATCATAAAAAGTTAAAGAGTAAG
GCTGCTGAAGACAAAAATAAGCCTCAAGAGAGAATACCATTTGACCGTGATAAAGATCTCAAGGTTAATCGGTTTGATGAAGCTCAGAAA
AAAGCCCTAATAAAAAAATCTAGAGAACTAAACACCAGATTTTCACACGGCAAAGGCAATATGTTTTTATAAGTAAGTATATTTCAGTGA
GGTATATTTTAATACTGATCAATGTGAACTTTTCTAAATACTCTATTGTCTTTAATAATTGTGCTGAAATCTATTTCCTTTTATAATAGA
TTAAAAATTTTATATTTTTATAAGTAAACAGTGATTTTTGAAAAGTCAGCCTTGTGGGATGAAAAATATGTCTTACTGGAAAAATCCCTC

>35191_35191_4_GTF2F2-GPALPP1_GTF2F2_chr13_45827105_ENST00000340473_GPALPP1_chr13_45589087_ENST00000379151_length(amino acids)=393AA_BP=189
MFRTPAPQPCGSWGRCCIPHASTGCRPMAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLA
NIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNY
KPVANHQYNETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTS
GDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GTF2F2-GPALPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GTF2F2-GPALPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GTF2F2-GPALPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource