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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GTF2I-EIF4H (FusionGDB2 ID:35221)

Fusion Gene Summary for GTF2I-EIF4H

check button Fusion gene summary
Fusion gene informationFusion gene name: GTF2I-EIF4H
Fusion gene ID: 35221
HgeneTgene
Gene symbol

GTF2I

EIF4H

Gene ID

2969

7458

Gene namegeneral transcription factor IIieukaryotic translation initiation factor 4H
SynonymsBAP135|BTKAP1|DIWS|GTFII-I|IB291|SPIN|TFII-I|WBS|WBSCR6WBSCR1|WSCR1|eIF-4H
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptiongeneral transcription factor II-IBTK-associated protein, 135kDBruton tyrosine kinase-associated protein 135SRF-Phox1-interacting proteinWilliams-Beuren syndrome chromosome region 6eukaryotic translation initiation factor 4HWilliams-Beuren syndrome chromosome region 1
Modification date2020031320200313
UniProtAcc

P78347

Q15056

Ensembl transtripts involved in fusion geneENST00000324896, ENST00000346152, 
ENST00000353920, ENST00000416070, 
ENST00000443166, ENST00000438130, 
ENST00000495187, ENST00000265753, 
ENST00000353999, 
Fusion gene scores* DoF score13 X 15 X 8=15603 X 3 X 2=18
# samples 143
** MAII scorelog2(14/1560*10)=-3.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GTF2I [Title/Abstract] AND EIF4H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF4H(73604248)-GTF2I(74173109), # samples:1
EIF4H(73604636)-GTF2I(74173109), # samples:1
EIF4H(73604636)-GTF2I(74173110), # samples:1
GTF2I(74131270)-EIF4H(73604003), # samples:1
Anticipated loss of major functional domain due to fusion event.GTF2I-EIF4H seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
GTF2I-EIF4H seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GTF2I-EIF4H seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
GTF2I-EIF4H seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GTF2I-EIF4H seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGTF2I

GO:0016525

negative regulation of angiogenesis

19242469


check buttonFusion gene breakpoints across GTF2I (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF4H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1718-01AGTF2Ichr7

74131270

+EIF4Hchr7

73604003

+


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Fusion Gene ORF analysis for GTF2I-EIF4H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000324896ENST00000495187GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
5CDS-3UTRENST00000346152ENST00000495187GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
5CDS-3UTRENST00000353920ENST00000495187GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
5CDS-3UTRENST00000416070ENST00000495187GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
5CDS-3UTRENST00000443166ENST00000495187GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
Frame-shiftENST00000443166ENST00000265753GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
Frame-shiftENST00000443166ENST00000353999GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000324896ENST00000265753GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000324896ENST00000353999GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000346152ENST00000265753GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000346152ENST00000353999GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000353920ENST00000265753GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000353920ENST00000353999GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000416070ENST00000265753GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
In-frameENST00000416070ENST00000353999GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
intron-3CDSENST00000438130ENST00000265753GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
intron-3CDSENST00000438130ENST00000353999GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+
intron-3UTRENST00000438130ENST00000495187GTF2Ichr7

74131270

+EIF4Hchr7

73604003

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324896GTF2Ichr774131270+ENST00000265753EIF4Hchr773604003+356212691191768549
ENST00000324896GTF2Ichr774131270+ENST00000353999EIF4Hchr773604003+349712691191708529
ENST00000353920GTF2Ichr774131270+ENST00000265753EIF4Hchr773604003+34291136461635529
ENST00000353920GTF2Ichr774131270+ENST00000353999EIF4Hchr773604003+33641136461575509
ENST00000346152GTF2Ichr774131270+ENST00000265753EIF4Hchr773604003+34891196461695549
ENST00000346152GTF2Ichr774131270+ENST00000353999EIF4Hchr773604003+34241196461635529
ENST00000416070GTF2Ichr774131270+ENST00000265753EIF4Hchr773604003+34291136461635529
ENST00000416070GTF2Ichr774131270+ENST00000353999EIF4Hchr773604003+33641136461575509

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324896ENST00000265753GTF2Ichr774131270+EIF4Hchr773604003+0.0010894880.99891055
ENST00000324896ENST00000353999GTF2Ichr774131270+EIF4Hchr773604003+0.0011148770.9988851
ENST00000353920ENST00000265753GTF2Ichr774131270+EIF4Hchr773604003+0.001136180.9988638
ENST00000353920ENST00000353999GTF2Ichr774131270+EIF4Hchr773604003+0.0010022330.99899775
ENST00000346152ENST00000265753GTF2Ichr774131270+EIF4Hchr773604003+0.0010093830.9989906
ENST00000346152ENST00000353999GTF2Ichr774131270+EIF4Hchr773604003+0.0010340580.998966
ENST00000416070ENST00000265753GTF2Ichr774131270+EIF4Hchr773604003+0.001136180.9988638
ENST00000416070ENST00000353999GTF2Ichr774131270+EIF4Hchr773604003+0.0010022330.99899775

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Fusion Genomic Features for GTF2I-EIF4H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GTF2Ichr774131270+EIF4Hchr773604002+7.50E-080.9999999
GTF2Ichr774131270+EIF4Hchr773604002+7.50E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GTF2I-EIF4H


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:73604248/chr7:74173109)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GTF2I

P78347

EIF4H

Q15056

FUNCTION: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.FUNCTION: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135103_1972931252.6666666666667RepeatNote=GTF2I-like 1
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134103_1972931256.0RepeatNote=GTF2I-like 1
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034103_1972731257.0RepeatNote=GTF2I-like 1
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033103_1972731237.3333333333333RepeatNote=GTF2I-like 1
TgeneEIF4Hchr7:74131270chr7:73604003ENST0000026575317137_15782249.0RegionNote=HHV-1 Vhs binding site
TgeneEIF4Hchr7:74131270chr7:73604003ENST0000035399916137_15782229.0RegionNote=HHV-1 Vhs binding site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135692_6952931252.6666666666667Compositional biasNote=Poly-Asn
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134692_6952931256.0Compositional biasNote=Poly-Asn
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034692_6952731257.0Compositional biasNote=Poly-Asn
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033692_6952731237.3333333333333Compositional biasNote=Poly-Asn
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135320_3272931252.6666666666667MotifNuclear localization signal
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134320_3272931256.0MotifNuclear localization signal
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034320_3272731257.0MotifNuclear localization signal
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033320_3272731237.3333333333333MotifNuclear localization signal
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135352_4462931252.6666666666667RepeatNote=GTF2I-like 2
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135457_5512931252.6666666666667RepeatNote=GTF2I-like 3
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135562_6562931252.6666666666667RepeatNote=GTF2I-like 4
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135724_8182931252.6666666666667RepeatNote=GTF2I-like 5
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000324896+1135859_9532931252.6666666666667RepeatNote=GTF2I-like 6
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134352_4462931256.0RepeatNote=GTF2I-like 2
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134457_5512931256.0RepeatNote=GTF2I-like 3
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134562_6562931256.0RepeatNote=GTF2I-like 4
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134724_8182931256.0RepeatNote=GTF2I-like 5
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000346152+1134859_9532931256.0RepeatNote=GTF2I-like 6
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034352_4462731257.0RepeatNote=GTF2I-like 2
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034457_5512731257.0RepeatNote=GTF2I-like 3
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034562_6562731257.0RepeatNote=GTF2I-like 4
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034724_8182731257.0RepeatNote=GTF2I-like 5
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000353920+1034859_9532731257.0RepeatNote=GTF2I-like 6
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033352_4462731237.3333333333333RepeatNote=GTF2I-like 2
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033457_5512731237.3333333333333RepeatNote=GTF2I-like 3
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033562_6562731237.3333333333333RepeatNote=GTF2I-like 4
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033724_8182731237.3333333333333RepeatNote=GTF2I-like 5
HgeneGTF2Ichr7:74131270chr7:73604003ENST00000416070+1033859_9532731237.3333333333333RepeatNote=GTF2I-like 6
TgeneEIF4Hchr7:74131270chr7:73604003ENST000002657531742_11882249.0DomainRRM
TgeneEIF4Hchr7:74131270chr7:73604003ENST000003539991642_11882229.0DomainRRM


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Fusion Gene Sequence for GTF2I-EIF4H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35221_35221_1_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000324896_EIF4H_chr7_73604003_ENST00000265753_length(transcript)=3562nt_BP=1269nt
AAAGAAAAAAAAAAGGAGGAGGAGGAGGAGGGTGAGAGAGAAGCTGGGAGAGCAGAGAAAAGGGGCCACCGGTCGCCCCCCCGCTTCCCC
GCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCGGATCAAGGCGCTGAGCG
AGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTCTCGCCTCCCGTCCGCTC
GCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGGCACCCCCGGCCCCGGAG
CTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGAGTCCTCGGAGAGCAGGA
TGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGCCTGCATTGCAGTGTATG
AAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGATTTTGTAAAATATTGTG
TTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGATGCTGTAGAAATTGAAA
CACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACCTGTACCATATGAGAAGA
TGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTATGATCTTGCAACCCTGA
AATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGTAGGTGGTCGTGTGATGG
TAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCACAGAAGATTCTGGCATTT
CCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGCAGGCCCTTCTGAAACTG
ATGATGTTGATGAAAAACAGCCCCTATCGAAGCCTTTGCAAGGAAGCCACCATTCTTCAGAGGGCAATGAAGGCACAGAAATGGAAGTAC
CAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTCCCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGT
CACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGGTGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGAATGGGTA
GCTCTCGAGAATCTAGAGGTGGATGGGATTCCCGGGATGACTTCAATTCTGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTC
GCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAAC
CCACAGAAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACT
CTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGG
GGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGTCCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGA
AACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCG
TTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTCGGA
GGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTGCTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCA
ACTCCAGGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGA
GTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGCTGTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGA
TAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGG
CTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAGAGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCAT
TCACACGTGTGTGTGTCCCAGCTAGTTCACTCCTTTCGCCGTGCGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCG
GGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCACTGGGCTGACTGCGGCGCTGACGCAGCGTT
TCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCTAGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAG
TTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTTCCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAG
CAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGGACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGG
AGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGAACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGG
GAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCG
GAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGCTTTTCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCT
CTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACCAACACTTAACTTCAGAAAGACATGCATTAT
GTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACATCTTCAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGC
TGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATAT

>35221_35221_1_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000324896_EIF4H_chr7_73604003_ENST00000265753_length(amino acids)=549AA_BP=383
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLS
KPLQGSHHSSEGNEGTEMEVPAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWD
SRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPR

--------------------------------------------------------------
>35221_35221_2_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000324896_EIF4H_chr7_73604003_ENST00000353999_length(transcript)=3497nt_BP=1269nt
AAAGAAAAAAAAAAGGAGGAGGAGGAGGAGGGTGAGAGAGAAGCTGGGAGAGCAGAGAAAAGGGGCCACCGGTCGCCCCCCCGCTTCCCC
GCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCGGATCAAGGCGCTGAGCG
AGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTCTCGCCTCCCGTCCGCTC
GCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGGCACCCCCGGCCCCGGAG
CTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGAGTCCTCGGAGAGCAGGA
TGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGCCTGCATTGCAGTGTATG
AAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGATTTTGTAAAATATTGTG
TTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGATGCTGTAGAAATTGAAA
CACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACCTGTACCATATGAGAAGA
TGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTATGATCTTGCAACCCTGA
AATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGTAGGTGGTCGTGTGATGG
TAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCACAGAAGATTCTGGCATTT
CCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGCAGGCCCTTCTGAAACTG
ATGATGTTGATGAAAAACAGCCCCTATCGAAGCCTTTGCAAGGAAGCCACCATTCTTCAGAGGGCAATGAAGGCACAGAAATGGAAGTAC
CAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTCCCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGT
CACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGGTGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGCTTCAGGG
ATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGGCCCTCCCC
TCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAAACCTCGAACAGTCGCGA
CGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGAG
CCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGTCCTGCAGCCGCCACTCC
TGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTT
TGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCTTG
TTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTGCTGCGTCATTTTTCCTT
TGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCT
GTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGCTGTGATGGATATAGAGA
ATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATGACCC
CCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAGAGCGGTAGGGAGTCCAC
GGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTGTGTCCCAGCTAGTTCACTCCTTTCGCCGTGCGTGGTGGAGGCTGGCC
TCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCA
CTGGGCTGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCTAGTATAGGCAACATAAT
GAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTTCCTTTGATAAATTGTAC
TATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGGACTGTT
CCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGAACAGATGAAAAATCCTT
CAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGG
CAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGCTTTTCCTACTGTGTCTTGTT
ACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACC
AACACTTAACTTCAGAAAGACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACATCTTCAATGTGGATAAGA
TAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAAACACTTAACACATTCAG

>35221_35221_2_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000324896_EIF4H_chr7_73604003_ENST00000353999_length(amino acids)=529AA_BP=383
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLS
KPLQGSHHSSEGNEGTEMEVPAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGS

--------------------------------------------------------------
>35221_35221_3_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000346152_EIF4H_chr7_73604003_ENST00000265753_length(transcript)=3489nt_BP=1196nt
CGCCCCCCCGCTTCCCCGCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCG
GATCAAGGCGCTGAGCGAGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTC
TCGCCTCCCGTCCGCTCGCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGG
CACCCCCGGCCCCGGAGCTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGA
GTCCTCGGAGAGCAGGATGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGC
CTGCATTGCAGTGTATGAAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGA
TTTTGTAAAATATTGTGTTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGA
TGCTGTAGAAATTGAAACACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACC
TGTACCATATGAGAAGATGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTA
TGATCTTGCAACCCTGAAATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGT
AGGTGGTCGTGTGATGGTAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCAC
AGAAGATTCTGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGC
AGGCCCTTCTGAAACTGATGATGTTGATGAAAAACAGCCCCTATCGAAGCCTTTGCAAGGAAGCCACCATTCTTCAGAGGGCAATGAAGG
CACAGAAATGGAAGTACCAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTCCCTTAAGGAAGCCTTGACATACGATGGTGC
ACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGGTGGCTTTGGATTCAGAAAAGGTGGACCAGA
TGACAGAGGAATGGGTAGCTCTCGAGAATCTAGAGGTGGATGGGATTCCCGGGATGACTTCAATTCTGGCTTCAGGGATGACTTCTTAGG
GGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGGCCCTCCCCTCCGTGGATCCAA
CATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCA
AGTAGCCAATCCCAACTCTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGAGCCTGCGGTTGGGA
GGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGTCCTGCAGCCGCCACTCCTGCGCCTGCCATT
GGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTTTGCTGTATCTATC
TAGTGCCTGTTTGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCTTGTTTTCCCAGCAGC
ACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTGCTGCGTCATTTTTCCTTTGCTTTCTCTTTA
CTTTAGACACTGGCCCAACTCCAGGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCTGTATTGCTGGGGC
TTCCAACAAAAACCAGAGTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGCTGTGATGGATATAGAGAATCAGAGGCACCT
TGTTTTCACAACTAGGATAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATGACCCCCTCCCGAGTGGA
CTGTCCAAGCAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAGAGCGGTAGGGAGTCCACGGAGAAGATGCAG
TGAATGCTTGCATGCATTCACACGTGTGTGTGTCCCAGCTAGTTCACTCCTTTCGCCGTGCGTGGTGGAGGCTGGCCTCTCTGGCTGGGT
GCAGTGAATGGCCAGCGGGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCACTGGGCTGACTGC
GGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCTAGTATAGGCAACATAATGAGATACTGTGCT
TCCCACCTCCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTTCCTTTGATAAATTGTACTATGCAGAGCTGT
CAGGAACCTTCAGATAGCAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGGACTGTTCCCATGTGCAGGG
TTCAGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGAACAGATGAAAAATCCTTCAGTACCCAAGTC
CCAGTCTGTCCTATGGGGAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGGCAGGGCCAGGGTG
GCCTGGGGCACCCAGCGGAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGCTTTTCCTACTGTGTCTTGTTACAAGGCCTCAGC
AATCCACAGAACTCTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACCAACACTTAACTTC
AGAAAGACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACATCTTCAATGTGGATAAGATAAAGAACAAAAC
ACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAA

>35221_35221_3_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000346152_EIF4H_chr7_73604003_ENST00000265753_length(amino acids)=549AA_BP=383
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLS
KPLQGSHHSSEGNEGTEMEVPAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWD
SRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPR

--------------------------------------------------------------
>35221_35221_4_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000346152_EIF4H_chr7_73604003_ENST00000353999_length(transcript)=3424nt_BP=1196nt
CGCCCCCCCGCTTCCCCGCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCG
GATCAAGGCGCTGAGCGAGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTC
TCGCCTCCCGTCCGCTCGCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGG
CACCCCCGGCCCCGGAGCTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGA
GTCCTCGGAGAGCAGGATGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGC
CTGCATTGCAGTGTATGAAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGA
TTTTGTAAAATATTGTGTTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGA
TGCTGTAGAAATTGAAACACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACC
TGTACCATATGAGAAGATGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTA
TGATCTTGCAACCCTGAAATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGT
AGGTGGTCGTGTGATGGTAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCAC
AGAAGATTCTGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGC
AGGCCCTTCTGAAACTGATGATGTTGATGAAAAACAGCCCCTATCGAAGCCTTTGCAAGGAAGCCACCATTCTTCAGAGGGCAATGAAGG
CACAGAAATGGAAGTACCAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTCCCTTAAGGAAGCCTTGACATACGATGGTGC
ACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGGTGGCTTTGGATTCAGAAAAGGTGGACCAGA
TGACAGAGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTT
CAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAA
ACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCA
AAAGGAGCAAGAATGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGT
CCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGGTTTT
TAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCT
TTTTCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTG
CTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGA
CCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGC
TGTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAG
TCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAG
AGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTGTGTCCCAGCTAGTTCACTCCTTTCGCCGTG
CGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGG
GTGGTGCTGGTGCTGCACTGGGCTGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCT
AGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTT
CCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGG
GGACACACTGGACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGA
ACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGG
CCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGCTTT
TCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGA
ACCATTTGTGTAACACCAACACTTAACTTCAGAAAGACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACAT
CTTCAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAA
ACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATTTTGTGAATGATCTTTTAAATAAAAGAAAACCTTACGT

>35221_35221_4_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000346152_EIF4H_chr7_73604003_ENST00000353999_length(amino acids)=529AA_BP=383
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQAGPSETDDVDEKQPLS
KPLQGSHHSSEGNEGTEMEVPAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGS

--------------------------------------------------------------
>35221_35221_5_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000353920_EIF4H_chr7_73604003_ENST00000265753_length(transcript)=3429nt_BP=1136nt
CGCCCCCCCGCTTCCCCGCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCG
GATCAAGGCGCTGAGCGAGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTC
TCGCCTCCCGTCCGCTCGCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGG
CACCCCCGGCCCCGGAGCTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGA
GTCCTCGGAGAGCAGGATGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGC
CTGCATTGCAGTGTATGAAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGA
TTTTGTAAAATATTGTGTTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGA
TGCTGTAGAAATTGAAACACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACC
TGTACCATATGAGAAGATGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTA
TGATCTTGCAACCCTGAAATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGT
AGGTGGTCGTGTGATGGTAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCAC
AGAAGATTCTGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGG
AAGCCACCATTCTTCAGAGGGCAATGAAGGCACAGAAATGGAAGTACCAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTC
CCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGG
TGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGAATGGGTAGCTCTCGAGAATCTAGAGGTGGATGGGATTCCCGGGATGACTT
CAATTCTGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTT
CAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAA
ACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCA
AAAGGAGCAAGAATGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGT
CCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGGTTTT
TAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCT
TTTTCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTG
CTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGA
CCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGC
TGTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAG
TCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAG
AGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTGTGTCCCAGCTAGTTCACTCCTTTCGCCGTG
CGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGG
GTGGTGCTGGTGCTGCACTGGGCTGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCT
AGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTT
CCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGG
GGACACACTGGACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGA
ACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGG
CCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGCTTT
TCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGA
ACCATTTGTGTAACACCAACACTTAACTTCAGAAAGACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACAT
CTTCAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAA
ACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATTTTGTGAATGATCTTTTAAATAAAAGAAAACCTTACGT

>35221_35221_5_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000353920_EIF4H_chr7_73604003_ENST00000265753_length(amino acids)=529AA_BP=363
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEV
PAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGS

--------------------------------------------------------------
>35221_35221_6_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000353920_EIF4H_chr7_73604003_ENST00000353999_length(transcript)=3364nt_BP=1136nt
CGCCCCCCCGCTTCCCCGCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCG
GATCAAGGCGCTGAGCGAGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTC
TCGCCTCCCGTCCGCTCGCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGG
CACCCCCGGCCCCGGAGCTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGA
GTCCTCGGAGAGCAGGATGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGC
CTGCATTGCAGTGTATGAAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGA
TTTTGTAAAATATTGTGTTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGA
TGCTGTAGAAATTGAAACACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACC
TGTACCATATGAGAAGATGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTA
TGATCTTGCAACCCTGAAATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGT
AGGTGGTCGTGTGATGGTAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCAC
AGAAGATTCTGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGG
AAGCCACCATTCTTCAGAGGGCAATGAAGGCACAGAAATGGAAGTACCAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTC
CCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGG
TGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCG
GCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGA
AAGAGCACAGAGACCACGACTCCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCGG
GGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGA
CCACAGCCTGGTGAGTCCCCGGGCAGCCGTCCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTG
AGTGCATGTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCT
TCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGG
CCGCCGTGGGGGGGCGTTTGGGCTGCGGTGCTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTT
CCTTTCATTCCCTCAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGAG
GGAACAGCAGAGACCTTGTTGGTATTCAGCTGTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGC
AGGGTCCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAA
CAGTGAGGCTGAAAGGGGGGGCTATGGAAGAGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTG
TGTCCCAGCTAGTTCACTCCTTTCGCCGTGCGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTTTCTTTTCTG
CTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCACTGGGCTGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCT
GTTGCCTGTGTGTTGTGTGGATCTGTTCCTAGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAA
TGGGTCTAGAATCTGGCACTTTACTCATTTCCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAGAGGACTG
CAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGGACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTT
AGGCTTTTGAGCTTGAACGCCTGCGTGTGAACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGG
GCGGCCGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGT
ATTTGGTCACCAGCCGTCATCCTGGGCTTTTCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCA
CCTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACCAACACTTAACTTCAGAAAGACATGCATTATGTGGTGTAATCAA
ACCCGATGCTTTCAGATGACCTACTTACATCTTCAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGT
TGACTTTTAAATGTAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATTTTGTGAA

>35221_35221_6_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000353920_EIF4H_chr7_73604003_ENST00000353999_length(amino acids)=509AA_BP=363
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEV
PAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPP

--------------------------------------------------------------
>35221_35221_7_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000416070_EIF4H_chr7_73604003_ENST00000265753_length(transcript)=3429nt_BP=1136nt
CGCCCCCCCGCTTCCCCGCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCG
GATCAAGGCGCTGAGCGAGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTC
TCGCCTCCCGTCCGCTCGCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGG
CACCCCCGGCCCCGGAGCTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGA
GTCCTCGGAGAGCAGGATGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGC
CTGCATTGCAGTGTATGAAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGA
TTTTGTAAAATATTGTGTTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGA
TGCTGTAGAAATTGAAACACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACC
TGTACCATATGAGAAGATGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTA
TGATCTTGCAACCCTGAAATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGT
AGGTGGTCGTGTGATGGTAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCAC
AGAAGATTCTGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGG
AAGCCACCATTCTTCAGAGGGCAATGAAGGCACAGAAATGGAAGTACCAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTC
CCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGG
TGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGAATGGGTAGCTCTCGAGAATCTAGAGGTGGATGGGATTCCCGGGATGACTT
CAATTCTGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCGGCGAACAGGCCCCCCCATGGGCAGCCGCTT
CAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGAAAGAGCACAGAGACCACGACTCCAGCTTAA
ACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCGGGGGTGCCAGGCCTAGAGAGGAAGTCGTTCA
AAAGGAGCAAGAATGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGACCACAGCCTGGTGAGTCCCCGGGCAGCCGT
CCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTGAGTGCATGTCAGCTGTTAACAAGTGGTTTT
TAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCTTCCGCTGCTTCCCCATTTTCCTTCTGTCCT
TTTTCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGGCCGCCGTGGGGGGGCGTTTGGGCTGCGGTG
CTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTTCCTTTCATTCCCTCAGTGCTTCTCTTCTGA
CCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGAGGGAACAGCAGAGACCTTGTTGGTATTCAGC
TGTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGCAGGGTCCTTTCCATTCCTATTTAGAGGGAG
TCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAACAGTGAGGCTGAAAGGGGGGGCTATGGAAG
AGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTGTGTCCCAGCTAGTTCACTCCTTTCGCCGTG
CGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTTTCTTTTCTGCTGGGCCAAGGCGCTTTGGGGGTGGAGGGG
GTGGTGCTGGTGCTGCACTGGGCTGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCTGTTGCCTGTGTGTTGTGTGGATCTGTTCCT
AGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAATGGGTCTAGAATCTGGCACTTTACTCATTT
CCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAGAGGACTGCAGCTGTCTAGGTCTGCGGCCACATCTTGG
GGACACACTGGACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTTAGGCTTTTGAGCTTGAACGCCTGCGTGTGA
ACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGGGCGGCCGGCAGCAGGAGCCTGGGAAAGAGG
CCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGTATTTGGTCACCAGCCGTCATCCTGGGCTTT
TCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCACCTGTCAGCTTCTCTGCTTCTGAGATAAGA
ACCATTTGTGTAACACCAACACTTAACTTCAGAAAGACATGCATTATGTGGTGTAATCAAACCCGATGCTTTCAGATGACCTACTTACAT
CTTCAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGTTGACTTTTAAATGTAAGAATGGAATTCCAA
ACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATTTTGTGAATGATCTTTTAAATAAAAGAAAACCTTACGT

>35221_35221_7_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000416070_EIF4H_chr7_73604003_ENST00000265753_length(amino acids)=529AA_BP=363
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEV
PAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGS

--------------------------------------------------------------
>35221_35221_8_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000416070_EIF4H_chr7_73604003_ENST00000353999_length(transcript)=3364nt_BP=1136nt
CGCCCCCCCGCTTCCCCGCACGCGCTCTCCAGCCGCGGCCGCCCGCCTGCCGCGGTCACCCCGGCCTCTGCCTCTGTCCCCCAGTGATCG
GATCAAGGCGCTGAGCGAGGCCCTGCCTGCGGGGCGGCCATGCGGCGGTGACAGGAGCGCGACCGACACGCACGGGCCCCTCGCCCCCTC
TCGCCTCCCGTCCGCTCGCCAGCTCCCCTCAGCCGAGGCTGCTCCGCGGCGGCCGCAGCCCGCGCGCGGCCCACACTCGCCTCCCCTCGG
CACCCCCGGCCCCGGAGCTGCCTGGAGGCGGCCGCACTCGGGGATCATGGCCCAAGTTGCAATGTCCACCCTCCCCGTTGAAGATGAGGA
GTCCTCGGAGAGCAGGATGGTGGTGACATTCCTCATGTCAGCTCTCGAGTCCATGTGTAAAGAACTGGCCAAGTCCAAAGCCGAAGTGGC
CTGCATTGCAGTGTATGAAACAGACGTGTTTGTCGTCGGAACTGAAAGAGGACGTGCTTTTGTCAATACCAGAAAGGATTTTCAAAAAGA
TTTTGTAAAATATTGTGTTGAAGAAGAAGAAAAAGCTGCAGAGATGCATAAAATGAAATCTACAACCCAGGCAAATCGGATGAGTGTAGA
TGCTGTAGAAATTGAAACACTCAGAAAAACAGTTGAGGACTATTTCTGCTTTTGCTATGGGAAAGCTTTAGGCAAATCCACAGTGGTACC
TGTACCATATGAGAAGATGCTGCGAGACCAGTCGGCTGTGGTAGTGCAGGGGCTTCCGGAAGGTGTTGCCTTTAAACACCCCGAGAACTA
TGATCTTGCAACCCTGAAATGGATTTTGGAGAACAAAGCAGGGATTTCATTCATCATTAAGAGACCTTTTTTAGAGCCAAAGAAGCATGT
AGGTGGTCGTGTGATGGTAACAGATGCTGACAGGTCAATACTATCTCCAGGTGGAAGTTGTGGCCCCATCAAAGTGAAAACTGAACCCAC
AGAAGATTCTGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAATCAGAAGATCCTGATTATTATCAATATAACATTCAAGG
AAGCCACCATTCTTCAGAGGGCAATGAAGGCACAGAAATGGAAGTACCAGCAGAAGGATTCTGCTATGTAGAATTCGATGAAGTGGATTC
CCTTAAGGAAGCCTTGACATACGATGGTGCACTGTTGGGCGATCGGTCACTTCGTGTGGACATTGCAGAAGGCAGAAAACAAGATAAAGG
TGGCTTTGGATTCAGAAAAGGTGGACCAGATGACAGAGGCTTCAGGGATGACTTCTTAGGGGGCAGGGGAGGTAGTCGCCCAGGCGACCG
GCGAACAGGCCCCCCCATGGGCAGCCGCTTCAGAGATGGCCCTCCCCTCCGTGGATCCAACATGGATTTCAGAGAACCCACAGAAGAGGA
AAGAGCACAGAGACCACGACTCCAGCTTAAACCTCGAACAGTCGCGACGCCCCTCAATCAAGTAGCCAATCCCAACTCTGCTATCTTCGG
GGGTGCCAGGCCTAGAGAGGAAGTCGTTCAAAAGGAGCAAGAATGAGCCTGCGGTTGGGAGGGAATGGGGCGTGGGGGGTTAGAGCAGGA
CCACAGCCTGGTGAGTCCCCGGGCAGCCGTCCTGCAGCCGCCACTCCTGCGCCTGCCATTGGCCTCCTCACAGCGGAAACACAGCTTGTG
AGTGCATGTCAGCTGTTAACAAGTGGTTTTTAGTACATTCTGGGCTTTGCTGTATCTATCTAGTGCCTGTTTGTGCGTTTTTTTCTTTCT
TCCGCTGCTTCCCCATTTTCCTTCTGTCCTTTTTCTCCTGCTCCTTGTTTTCCCAGCAGCACATGGGGTTCCTCGGAGGAGCAGAGGTGG
CCGCCGTGGGGGGGCGTTTGGGCTGCGGTGCTGCGTCATTTTTCCTTTGCTTTCTCTTTACTTTAGACACTGGCCCAACTCCAGGCGTTT
CCTTTCATTCCCTCAGTGCTTCTCTTCTGACCTGCATGTTGAGTTCTGTATTGCTGGGGCTTCCAACAAAAACCAGAGTCACTGACAGAG
GGAACAGCAGAGACCTTGTTGGTATTCAGCTGTGATGGATATAGAGAATCAGAGGCACCTTGTTTTCACAACTAGGATAAAAATATCTGC
AGGGTCCTTTCCATTCCTATTTAGAGGGAGTCCTGGCTCCATGACCCCCTCCCGAGTGGACTGTCCAAGCAGATAGGCTCACACGAGAAA
CAGTGAGGCTGAAAGGGGGGGCTATGGAAGAGCGGTAGGGAGTCCACGGAGAAGATGCAGTGAATGCTTGCATGCATTCACACGTGTGTG
TGTCCCAGCTAGTTCACTCCTTTCGCCGTGCGTGGTGGAGGCTGGCCTCTCTGGCTGGGTGCAGTGAATGGCCAGCGGGTTTCTTTTCTG
CTGGGCCAAGGCGCTTTGGGGGTGGAGGGGGTGGTGCTGGTGCTGCACTGGGCTGACTGCGGCGCTGACGCAGCGTTTCCCCCCATCCCT
GTTGCCTGTGTGTTGTGTGGATCTGTTCCTAGTATAGGCAACATAATGAGATACTGTGCTTCCCACCTCCCCTTCAGTTCAGAGCCAAAA
TGGGTCTAGAATCTGGCACTTTACTCATTTCCTTTGATAAATTGTACTATGCAGAGCTGTCAGGAACCTTCAGATAGCAGTAGAGGACTG
CAGCTGTCTAGGTCTGCGGCCACATCTTGGGGACACACTGGACTGTTCCCATGTGCAGGGTTCAGCAGTTATGTGGGAGTGCTAGGGGTT
AGGCTTTTGAGCTTGAACGCCTGCGTGTGAACAGATGAAAAATCCTTCAGTACCCAAGTCCCAGTCTGTCCTATGGGGAGCAGTTTGGGG
GCGGCCGGCAGCAGGAGCCTGGGAAAGAGGCCCTCGCCAGGTGATGGCAGGGCCAGGGTGGCCTGGGGCACCCAGCGGAATGTGCTTAGT
ATTTGGTCACCAGCCGTCATCCTGGGCTTTTCCTACTGTGTCTTGTTACAAGGCCTCAGCAATCCACAGAACTCTCTCTCCTTCCTTCCA
CCTGTCAGCTTCTCTGCTTCTGAGATAAGAACCATTTGTGTAACACCAACACTTAACTTCAGAAAGACATGCATTATGTGGTGTAATCAA
ACCCGATGCTTTCAGATGACCTACTTACATCTTCAATGTGGATAAGATAAAGAACAAAACACATGCATCTAAACTGCTGGGCAATCCAGT
TGACTTTTAAATGTAAGAATGGAATTCCAAACACTTAACACATTCAGCTATATGACAGAAAGTAAATCTATGGATATGGTATTTTGTGAA

>35221_35221_8_GTF2I-EIF4H_GTF2I_chr7_74131270_ENST00000416070_EIF4H_chr7_73604003_ENST00000353999_length(amino acids)=509AA_BP=363
MPRSPRPLPLSPSDRIKALSEALPAGRPCGGDRSATDTHGPLAPSRLPSARQLPSAEAAPRRPQPARGPHSPPLGTPGPGAAWRRPHSGI
MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEM
HKMKSTTQANRMSVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI
SFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPIKVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEV
PAEGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GTF2I-EIF4H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GTF2I-EIF4H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GTF2I-EIF4H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource