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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GUK1-TARBP1 (FusionGDB2 ID:35368)

Fusion Gene Summary for GUK1-TARBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GUK1-TARBP1
Fusion gene ID: 35368
HgeneTgene
Gene symbol

GUK1

TARBP1

Gene ID

2987

6894

Gene nameguanylate kinase 1TAR (HIV-1) RNA binding protein 1
SynonymsGMKTRM3|TRMT3|TRP-185|TRP185
Cytomap

1q42.13

1q42.2

Type of geneprotein-codingprotein-coding
Descriptionguanylate kinaseATP:GMP phosphotransferaseGMP kinaseprobable methyltransferase TARBP1TAR (HIV) RNA-binding protein 1TAR RNA loop binding proteinTAR RNA-binding protein 1TAR RNA-binding protein of 185 kDatRNA methyltransferase 3 homolog
Modification date2020032020200313
UniProtAcc

Q16774

.
Ensembl transtripts involved in fusion geneENST00000366723, ENST00000366728, 
ENST00000391865, ENST00000312726, 
ENST00000366721, ENST00000366722, 
ENST00000366726, ENST00000366716, 
ENST00000366718, ENST00000366730, 
ENST00000470040, 		ENST00000483404, 
ENST00000040877, 
Fusion gene scores* DoF score14 X 13 X 6=10923 X 3 X 3=27
# samples 163
** MAII scorelog2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GUK1 [Title/Abstract] AND TARBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGUK1(228328064)-TARBP1(234603396), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

HgeneGUK1

GO:0006805

xenobiotic metabolic process

6306664


check buttonFusion gene breakpoints across GUK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TARBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GM-A3XL-01AGUK1chr1

228328064

+TARBP1chr1

234603396

-


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Fusion Gene ORF analysis for GUK1-TARBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000366723ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
5CDS-intronENST00000366728ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
5CDS-intronENST00000391865ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-3CDSENST00000312726ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-3CDSENST00000366721ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-3CDSENST00000366722ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-3CDSENST00000366726ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-intronENST00000312726ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-intronENST00000366721ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-intronENST00000366722ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
5UTR-intronENST00000366726ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
In-frameENST00000366723ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
In-frameENST00000366728ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
In-frameENST00000391865ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-3CDSENST00000366716ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-3CDSENST00000366718ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-3CDSENST00000366730ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-3CDSENST00000470040ENST00000040877GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-intronENST00000366716ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-intronENST00000366718ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-intronENST00000366730ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-
intron-intronENST00000470040ENST00000483404GUK1chr1

228328064

+TARBP1chr1

234603396

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391865GUK1chr1228328064+ENST00000040877TARBP1chr1234603396-41671363639021288
ENST00000366728GUK1chr1228328064+ENST00000040877TARBP1chr1234603396-4105741338401275
ENST00000366723GUK1chr1228328064+ENST00000040877TARBP1chr1234603396-409362138281275

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391865ENST00000040877GUK1chr1228328064+TARBP1chr1234603396-0.0002101310.9997899
ENST00000366728ENST00000040877GUK1chr1228328064+TARBP1chr1234603396-0.0002053910.99979466
ENST00000366723ENST00000040877GUK1chr1228328064+TARBP1chr1234603396-0.0002027910.9997973

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Fusion Genomic Features for GUK1-TARBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GUK1-TARBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:228328064/chr1:234603396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUK1

Q16774

.
FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250|UniProtKB:P46195, ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273, ECO:0000269|PubMed:6248551, ECO:0000269|PubMed:6306664}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228328064chr1:234603396ENST00000366728+1714_1920242.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000391865+1814_1920219.0Nucleotide bindingATP
TgeneTARBP1chr1:228328064chr1:234603396ENST000000408772301543_15453661622.0RegionS-adenosyl-L-methionine binding
TgeneTARBP1chr1:228328064chr1:234603396ENST000000408772301586_15953661622.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228328064chr1:234603396ENST00000312726+194_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000366716+174_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000366718+184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000366726+184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000366728+174_18620242.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000366730+184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000391865+184_18620219.0DomainGuanylate kinase-like
HgeneGUK1chr1:228328064chr1:234603396ENST00000312726+1914_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000312726+19171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000312726+1937_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228328064chr1:234603396ENST00000366716+1714_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366716+17171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366716+1737_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228328064chr1:234603396ENST00000366718+1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366718+18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366718+1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228328064chr1:234603396ENST00000366726+1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366726+18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366726+1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228328064chr1:234603396ENST00000366728+17171_17220242.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366728+1737_5120242.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228328064chr1:234603396ENST00000366730+1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366730+18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000366730+1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228328064chr1:234603396ENST00000391865+18171_17220219.0Nucleotide bindingATP
HgeneGUK1chr1:228328064chr1:234603396ENST00000391865+1837_5120219.0Nucleotide bindingSubstrate binding
TgeneTARBP1chr1:228328064chr1:234603396ENST0000004087723099_2193661622.0Compositional biasNote=Ala-rich


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Fusion Gene Sequence for GUK1-TARBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35368_35368_1_GUK1-TARBP1_GUK1_chr1_228328064_ENST00000366723_TARBP1_chr1_234603396_ENST00000040877_length(transcript)=4093nt_BP=62nt
GATGCTGCGGCGCCCGCTGGCCGGGCTGGCTGCGGCCGCCCTGGGCCGGGCCCCACCGGACGGATGTTGGCTCTTTCACCCATCCTGGCA
TATGTGTATTTATAAAAGAATGTTTGAAAGTGAAAACAAAATCCTGTCCAAAGAAGGTGTTATCCATTTTTTGGAGCTGTATGAAACAAA
GATTCTTCCATTTTCACCAGAATTTTCTGAGTTTATTATTGGACCATTAATGGATGCGCTTTCAGAGAGCTCTCTGTATAGCAGGTCCCC
AGGCCAGCCAATAGGAAGCTGTTCTCCATTGGGACTGAAATTACAGAAGTTTTTAGTCACTTATATTTCTCTTCTTCCAGAAGAAATAAA
GAGTAGCTTCCTATTGAAGTTTATTCGGAAGATGACAAGTAGGCATTGGTGTGCTGTTCCCATTTTGTTTCTATCTAAGGCTTTGGCAAA
TGTCCCAAGACATAAGGCCCTGGGTATAGATGGGCTTCTTGCTCTCAGGGATGTTATTCATTGCACTATGATCACACATCAGATTCTCCT
GAGAGGGGCAGCCCAATGCTACCTTCTTCAAACAGCTATGAATTTGCTAGATGTGGAGAAAGTGTCACTTTCTGATGTCTCAACTTTTCT
CATGTCTCTGAGACAAGAGGAATCCTTAGGACGAGGAACTTCATTGTGGACAGAGCTGTGTGACTGGCTACGTGTTAATGAAAGCTATTT
TAAGCCATCCCCTACGTGTAGCTCCATTGGACTTCACAAGACATCTTTAAATGCTTATGTAAAGAGCATTGTTCAAGAGTATGTTAAGTC
ATCTGCTTGGGAAACAGGAGAAAACTGCTTTATGCCTGATTGGTTTGAAGCCAAGCTTGTTTCTCTGATGGTCTTGCTGGCTGTGGATGT
GGAAGGAATGAAGACTCAGTATAGCGGAAAGCAGAGAACAGAGAATGTATTGCGGATATTCTTAGACCCTCTTCTGGATGTGCTTATGAA
GTTTAGTACCAATGCCTACATGCCCTTGCTGAAGACTGACAGATGCCTCCAGCTGCTGTTGAAGCTGTTGAACACATGCAGGTTGAAAGG
TTCCAGTGCCCAAGATGATGAGGTGTCTACTGTTCTTCAGAACTTTTTCATGTCTACTACAGAGAGCATTTCTGAATTTATTCTCAGAAG
ACTTACTATGAATGAGCTAAATAGTGTTTCAGATCTGGATCGTTGCCATTTATACCTGATGGTGTTAACTGAGCTTATAAATCTGCATTT
GAAGGTTGGGTGGAAAAGGGGTAACCCTATCTGGAGAGTTATTTCTCTTTTGAAAAATGCATCCATTCAGCATCTTCAAGAGATGGACAG
TGGACAGGAGCCAACAGTTGGAAGTCAGATTCAGAGAGTAGTGAGCATGGCTGCCTTGGCCATGGTGTGTGAGGCCATAGACCAGAAGCC
TGAGCTGCAGCTGGACTCTCTCCATGCTGGGCCCCTGGAAAGCTTCCTTTCCTCTCTTCAGCTCAATCAGACGCTGCAGAAGCCCCACGC
AGAGGAGCAGAGCAGTTATGCTCACCCCTTGGAGTGCAGCAGTGTTTTGGAAGAATCGTCATCTTCCCAAGGATGGGGAAAAATAGTTGC
ACAATATATTCATGATCAATGGGTGTGCCTCTCTTTCCTGTTGAAAAAATATCACACCCTTATACCAACCACAGGGAGTGAAATTCTGGA
ACCGTTTCTACCTGCCGTTCAGATGCCAATAAGGACTTTGCAGTCTGCACTAGAAGCCCTCACAGTTCTTTCTTCTGATCAAGTTTTACC
AGTGTTCCATTGCTTGAAAGTGTTGGTTCCCAAGCTTCTGACTTCCTCTGAATCACTCTGCATAGAGTCTTTTGACATGGCGTGGAAAAT
TATATCTTCTTTAAGCAACACTCAGCTGATATTCTGGGCTAATTTAAAAGCTTTTGTTCAGTTTGTTTTTGATAACAAAGTTCTTACCAT
TGCTGCCAAAATCAAGGGCCAGGCATATTTCAAAATAAAAGAGATTATGTACAAGATAATTGAAATGTCTGCTATAAAGACTGGAGTCTT
CAATACACTGATAAGTTACTGCTGTCAGTCTTGGATAGTGTCTGCTTCAAATGTGTCCCAAGGATCTTTATCAAGTGCTAAAAATTATAG
CGAACTTATCCTTGAGGCTTGTATATTTGGAACTGTGTTTAGGCGTGATCAAAGACTTGTTCAGGATGTACAGACCTTCATAGAAAACCT
TGGACATGACTGTGCGGCAAATATTGTTATGGAAAATACTAAGAGAGAAGACCATTATGTGAGAATTTGTGCTGTCAAATTCCTGTGTTT
ATTAGATGGCTCCAATATGTCCCACAAGTTGTTTATTGAGGATCTTGCAATCAAGCTATTAGATAAAGATGAATTAGTGTCCAAGTCCAA
AAAACGCTACTATGTGAATTCTCTACAGCACAGAGTGAAAAACCGAGTGTGGCAGACTCTGCTGGTACTTTTCCCTAGACTTGACCAGAA
TTTCTTGAATGGAATTATTGACAGGATTTTCCAGGCTGGTTTCACCAACAATCAAGCATCCATAAAATATTTTATAGAATGGATTATTAT
ATTGATTCTTCATAAATTCCCTCAATTTCTTCCAAAGTTCTGGGATTGTTTTTCTTATGGTGAAGAAAATCTTAAAACAAGCATTTGTAC
GTTTTTAGCAGTTTTATCACATTTAGACATTATTACTCAAAATATTCCAGAAAAGAAACTAATTCTGAAGCAAGCCCTTATAGTTGTGCT
GCAGTGGTGTTTCAATCACAATTTTAGTGTTCGACTGTATGCTTTAGTTGCTCTTAAGAAACTCTGGACTGTGTGTAAAGTGTTAAGTGT
TGAAGAATTTGATGCCCTGACTCCTGTGATTGAATCCAGCCTCCATCAAGTGGAAAGCATGCACGGAGCAGGGAATGCCAAGAAGAATTG
GCAACGCATTCAGGAGCATTTCTTTTTTGCAACATTTCACCCACTCAAGGATTATTGTCTAGAGACCATATTTTACATCCTTCCACGCCT
TTCAGGCCTTATTGAAGATGAATGGATCACCATTGATAAATTTACCAGATTCACTGATGTTCCTTTAGCTGCGGGATTTCAGTGGTACCT
TTCTCAAACTCAACTTAGTAAACTAAAACCAGGTGACTGGTCTCAGCAAGACATAGGTACTAATTTGGTCGAAGCAGATAACCAAGCGGA
GTGGACCGACGTTCAGAAGAAGATTATCCCGTGGAACAGTCGTGTTTCCGACTTAGACCTGGAGCTCCTGTTTCAGGATCGTGCTGCCAG
ACTTGGAAAGTCAATTAGTAGACTCATCGTTGTGGCCTCGCTCATCGACAAACCGACCAATTTAGGAGGACTGTGCAGGACCTGTGAGGT
ATTTGGGGCTTCAGTGCTCGTTGTTGGCAGCCTTCAGTGTATCAGCGACAAACAGTTTCAGCACCTCAGTGTCTCTGCAGAACAGTGGCT
TCCTCTAGTGGAGGTAAAACCACCTCAGCTAATTGATTATCTGCAGCAGAAGAAAACAGAAGGTTATACCATCATTGGAGTGGAACAAAC
TGCCAAAAGTTTAGACCTAACCCAATATTGCTTTCCTGAGAAATCTCTGCTCTTGTTGGGAAATGAACGTGAGGGAATTCCAGCAAATCT
GATCCAACAGTTGGACGTTTGTGTGGAAATTCCTCAACAGGGCATTATCCGCTCCCTGAATGTCCATGTGAGTGGAGCCCTGCTGATCTG
GGAGTACACCAGGCAGCAGCTGCTCTCGCACGGAGATACCAAGCCATGATGTGCCTTCCTTAGTGAACTGCTGCTGCTGTTCAGACTTTT
TTAAAAAAAACTATTTGGACTAAAGAAACAGATTCTGAAATTTATTGTGATAATTTGTATTTCTTTTTTCTTGCAATTTAATGCCAAAAG
TTTGCCATGTGCCTTAAACATATTACTATATATTTTCCCCTTTAATAAACACTTTTTGTTAAATTGTATTCTTCCTTTAATAAAATATTT

>35368_35368_1_GUK1-TARBP1_GUK1_chr1_228328064_ENST00000366723_TARBP1_chr1_234603396_ENST00000040877_length(amino acids)=1275AA_BP=20
MLRRPLAGLAAAALGRAPPDGCWLFHPSWHMCIYKRMFESENKILSKEGVIHFLELYETKILPFSPEFSEFIIGPLMDALSESSLYSRSP
GQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSFLLKFIRKMTSRHWCAVPILFLSKALANVPRHKALGIDGLLALRDVIHCTMITHQILL
RGAAQCYLLQTAMNLLDVEKVSLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKTSLNAYVKSIVQEYVKS
SAWETGENCFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTENVLRIFLDPLLDVLMKFSTNAYMPLLKTDRCLQLLLKLLNTCRLKG
SSAQDDEVSTVLQNFFMSTTESISEFILRRLTMNELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVISLLKNASIQHLQEMDS
GQEPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLESFLSSLQLNQTLQKPHAEEQSSYAHPLECSSVLEESSSSQGWGKIVA
QYIHDQWVCLSFLLKKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLTSSESLCIESFDMAWKI
ISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKEIMYKIIEMSAIKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYS
ELILEACIFGTVFRRDQRLVQDVQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIEDLAIKLLDKDELVSKSK
KRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGFTNNQASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICT
FLAVLSHLDIITQNIPEKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSLHQVESMHGAGNAKKNW
QRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITIDKFTRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAE
WTDVQKKIIPWNSRVSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQFQHLSVSAEQWL
PLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIW

--------------------------------------------------------------
>35368_35368_2_GUK1-TARBP1_GUK1_chr1_228328064_ENST00000366728_TARBP1_chr1_234603396_ENST00000040877_length(transcript)=4105nt_BP=74nt
GAGGTGGCCCCGGATGCTGCGGCGCCCGCTGGCCGGGCTGGCTGCGGCCGCCCTGGGCCGGGCCCCACCGGACGGATGTTGGCTCTTTCA
CCCATCCTGGCATATGTGTATTTATAAAAGAATGTTTGAAAGTGAAAACAAAATCCTGTCCAAAGAAGGTGTTATCCATTTTTTGGAGCT
GTATGAAACAAAGATTCTTCCATTTTCACCAGAATTTTCTGAGTTTATTATTGGACCATTAATGGATGCGCTTTCAGAGAGCTCTCTGTA
TAGCAGGTCCCCAGGCCAGCCAATAGGAAGCTGTTCTCCATTGGGACTGAAATTACAGAAGTTTTTAGTCACTTATATTTCTCTTCTTCC
AGAAGAAATAAAGAGTAGCTTCCTATTGAAGTTTATTCGGAAGATGACAAGTAGGCATTGGTGTGCTGTTCCCATTTTGTTTCTATCTAA
GGCTTTGGCAAATGTCCCAAGACATAAGGCCCTGGGTATAGATGGGCTTCTTGCTCTCAGGGATGTTATTCATTGCACTATGATCACACA
TCAGATTCTCCTGAGAGGGGCAGCCCAATGCTACCTTCTTCAAACAGCTATGAATTTGCTAGATGTGGAGAAAGTGTCACTTTCTGATGT
CTCAACTTTTCTCATGTCTCTGAGACAAGAGGAATCCTTAGGACGAGGAACTTCATTGTGGACAGAGCTGTGTGACTGGCTACGTGTTAA
TGAAAGCTATTTTAAGCCATCCCCTACGTGTAGCTCCATTGGACTTCACAAGACATCTTTAAATGCTTATGTAAAGAGCATTGTTCAAGA
GTATGTTAAGTCATCTGCTTGGGAAACAGGAGAAAACTGCTTTATGCCTGATTGGTTTGAAGCCAAGCTTGTTTCTCTGATGGTCTTGCT
GGCTGTGGATGTGGAAGGAATGAAGACTCAGTATAGCGGAAAGCAGAGAACAGAGAATGTATTGCGGATATTCTTAGACCCTCTTCTGGA
TGTGCTTATGAAGTTTAGTACCAATGCCTACATGCCCTTGCTGAAGACTGACAGATGCCTCCAGCTGCTGTTGAAGCTGTTGAACACATG
CAGGTTGAAAGGTTCCAGTGCCCAAGATGATGAGGTGTCTACTGTTCTTCAGAACTTTTTCATGTCTACTACAGAGAGCATTTCTGAATT
TATTCTCAGAAGACTTACTATGAATGAGCTAAATAGTGTTTCAGATCTGGATCGTTGCCATTTATACCTGATGGTGTTAACTGAGCTTAT
AAATCTGCATTTGAAGGTTGGGTGGAAAAGGGGTAACCCTATCTGGAGAGTTATTTCTCTTTTGAAAAATGCATCCATTCAGCATCTTCA
AGAGATGGACAGTGGACAGGAGCCAACAGTTGGAAGTCAGATTCAGAGAGTAGTGAGCATGGCTGCCTTGGCCATGGTGTGTGAGGCCAT
AGACCAGAAGCCTGAGCTGCAGCTGGACTCTCTCCATGCTGGGCCCCTGGAAAGCTTCCTTTCCTCTCTTCAGCTCAATCAGACGCTGCA
GAAGCCCCACGCAGAGGAGCAGAGCAGTTATGCTCACCCCTTGGAGTGCAGCAGTGTTTTGGAAGAATCGTCATCTTCCCAAGGATGGGG
AAAAATAGTTGCACAATATATTCATGATCAATGGGTGTGCCTCTCTTTCCTGTTGAAAAAATATCACACCCTTATACCAACCACAGGGAG
TGAAATTCTGGAACCGTTTCTACCTGCCGTTCAGATGCCAATAAGGACTTTGCAGTCTGCACTAGAAGCCCTCACAGTTCTTTCTTCTGA
TCAAGTTTTACCAGTGTTCCATTGCTTGAAAGTGTTGGTTCCCAAGCTTCTGACTTCCTCTGAATCACTCTGCATAGAGTCTTTTGACAT
GGCGTGGAAAATTATATCTTCTTTAAGCAACACTCAGCTGATATTCTGGGCTAATTTAAAAGCTTTTGTTCAGTTTGTTTTTGATAACAA
AGTTCTTACCATTGCTGCCAAAATCAAGGGCCAGGCATATTTCAAAATAAAAGAGATTATGTACAAGATAATTGAAATGTCTGCTATAAA
GACTGGAGTCTTCAATACACTGATAAGTTACTGCTGTCAGTCTTGGATAGTGTCTGCTTCAAATGTGTCCCAAGGATCTTTATCAAGTGC
TAAAAATTATAGCGAACTTATCCTTGAGGCTTGTATATTTGGAACTGTGTTTAGGCGTGATCAAAGACTTGTTCAGGATGTACAGACCTT
CATAGAAAACCTTGGACATGACTGTGCGGCAAATATTGTTATGGAAAATACTAAGAGAGAAGACCATTATGTGAGAATTTGTGCTGTCAA
ATTCCTGTGTTTATTAGATGGCTCCAATATGTCCCACAAGTTGTTTATTGAGGATCTTGCAATCAAGCTATTAGATAAAGATGAATTAGT
GTCCAAGTCCAAAAAACGCTACTATGTGAATTCTCTACAGCACAGAGTGAAAAACCGAGTGTGGCAGACTCTGCTGGTACTTTTCCCTAG
ACTTGACCAGAATTTCTTGAATGGAATTATTGACAGGATTTTCCAGGCTGGTTTCACCAACAATCAAGCATCCATAAAATATTTTATAGA
ATGGATTATTATATTGATTCTTCATAAATTCCCTCAATTTCTTCCAAAGTTCTGGGATTGTTTTTCTTATGGTGAAGAAAATCTTAAAAC
AAGCATTTGTACGTTTTTAGCAGTTTTATCACATTTAGACATTATTACTCAAAATATTCCAGAAAAGAAACTAATTCTGAAGCAAGCCCT
TATAGTTGTGCTGCAGTGGTGTTTCAATCACAATTTTAGTGTTCGACTGTATGCTTTAGTTGCTCTTAAGAAACTCTGGACTGTGTGTAA
AGTGTTAAGTGTTGAAGAATTTGATGCCCTGACTCCTGTGATTGAATCCAGCCTCCATCAAGTGGAAAGCATGCACGGAGCAGGGAATGC
CAAGAAGAATTGGCAACGCATTCAGGAGCATTTCTTTTTTGCAACATTTCACCCACTCAAGGATTATTGTCTAGAGACCATATTTTACAT
CCTTCCACGCCTTTCAGGCCTTATTGAAGATGAATGGATCACCATTGATAAATTTACCAGATTCACTGATGTTCCTTTAGCTGCGGGATT
TCAGTGGTACCTTTCTCAAACTCAACTTAGTAAACTAAAACCAGGTGACTGGTCTCAGCAAGACATAGGTACTAATTTGGTCGAAGCAGA
TAACCAAGCGGAGTGGACCGACGTTCAGAAGAAGATTATCCCGTGGAACAGTCGTGTTTCCGACTTAGACCTGGAGCTCCTGTTTCAGGA
TCGTGCTGCCAGACTTGGAAAGTCAATTAGTAGACTCATCGTTGTGGCCTCGCTCATCGACAAACCGACCAATTTAGGAGGACTGTGCAG
GACCTGTGAGGTATTTGGGGCTTCAGTGCTCGTTGTTGGCAGCCTTCAGTGTATCAGCGACAAACAGTTTCAGCACCTCAGTGTCTCTGC
AGAACAGTGGCTTCCTCTAGTGGAGGTAAAACCACCTCAGCTAATTGATTATCTGCAGCAGAAGAAAACAGAAGGTTATACCATCATTGG
AGTGGAACAAACTGCCAAAAGTTTAGACCTAACCCAATATTGCTTTCCTGAGAAATCTCTGCTCTTGTTGGGAAATGAACGTGAGGGAAT
TCCAGCAAATCTGATCCAACAGTTGGACGTTTGTGTGGAAATTCCTCAACAGGGCATTATCCGCTCCCTGAATGTCCATGTGAGTGGAGC
CCTGCTGATCTGGGAGTACACCAGGCAGCAGCTGCTCTCGCACGGAGATACCAAGCCATGATGTGCCTTCCTTAGTGAACTGCTGCTGCT
GTTCAGACTTTTTTAAAAAAAACTATTTGGACTAAAGAAACAGATTCTGAAATTTATTGTGATAATTTGTATTTCTTTTTTCTTGCAATT
TAATGCCAAAAGTTTGCCATGTGCCTTAAACATATTACTATATATTTTCCCCTTTAATAAACACTTTTTGTTAAATTGTATTCTTCCTTT

>35368_35368_2_GUK1-TARBP1_GUK1_chr1_228328064_ENST00000366728_TARBP1_chr1_234603396_ENST00000040877_length(amino acids)=1275AA_BP=20
MLRRPLAGLAAAALGRAPPDGCWLFHPSWHMCIYKRMFESENKILSKEGVIHFLELYETKILPFSPEFSEFIIGPLMDALSESSLYSRSP
GQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSFLLKFIRKMTSRHWCAVPILFLSKALANVPRHKALGIDGLLALRDVIHCTMITHQILL
RGAAQCYLLQTAMNLLDVEKVSLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKTSLNAYVKSIVQEYVKS
SAWETGENCFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTENVLRIFLDPLLDVLMKFSTNAYMPLLKTDRCLQLLLKLLNTCRLKG
SSAQDDEVSTVLQNFFMSTTESISEFILRRLTMNELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVISLLKNASIQHLQEMDS
GQEPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLESFLSSLQLNQTLQKPHAEEQSSYAHPLECSSVLEESSSSQGWGKIVA
QYIHDQWVCLSFLLKKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLTSSESLCIESFDMAWKI
ISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKEIMYKIIEMSAIKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYS
ELILEACIFGTVFRRDQRLVQDVQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIEDLAIKLLDKDELVSKSK
KRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGFTNNQASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICT
FLAVLSHLDIITQNIPEKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSLHQVESMHGAGNAKKNW
QRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITIDKFTRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAE
WTDVQKKIIPWNSRVSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQFQHLSVSAEQWL
PLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIW

--------------------------------------------------------------
>35368_35368_3_GUK1-TARBP1_GUK1_chr1_228328064_ENST00000391865_TARBP1_chr1_234603396_ENST00000040877_length(transcript)=4167nt_BP=136nt
AGTCTCGCGCGCGGGCGGAGGTGGGCCGGTGCGGCGCTGTCACGTAGGTTCAGTGGGCGGAAGAGGTGGCCCCGGATGCTGCGGCGCCCG
CTGGCCGGGCTGGCTGCGGCCGCCCTGGGCCGGGCCCCACCGGACGGATGTTGGCTCTTTCACCCATCCTGGCATATGTGTATTTATAAA
AGAATGTTTGAAAGTGAAAACAAAATCCTGTCCAAAGAAGGTGTTATCCATTTTTTGGAGCTGTATGAAACAAAGATTCTTCCATTTTCA
CCAGAATTTTCTGAGTTTATTATTGGACCATTAATGGATGCGCTTTCAGAGAGCTCTCTGTATAGCAGGTCCCCAGGCCAGCCAATAGGA
AGCTGTTCTCCATTGGGACTGAAATTACAGAAGTTTTTAGTCACTTATATTTCTCTTCTTCCAGAAGAAATAAAGAGTAGCTTCCTATTG
AAGTTTATTCGGAAGATGACAAGTAGGCATTGGTGTGCTGTTCCCATTTTGTTTCTATCTAAGGCTTTGGCAAATGTCCCAAGACATAAG
GCCCTGGGTATAGATGGGCTTCTTGCTCTCAGGGATGTTATTCATTGCACTATGATCACACATCAGATTCTCCTGAGAGGGGCAGCCCAA
TGCTACCTTCTTCAAACAGCTATGAATTTGCTAGATGTGGAGAAAGTGTCACTTTCTGATGTCTCAACTTTTCTCATGTCTCTGAGACAA
GAGGAATCCTTAGGACGAGGAACTTCATTGTGGACAGAGCTGTGTGACTGGCTACGTGTTAATGAAAGCTATTTTAAGCCATCCCCTACG
TGTAGCTCCATTGGACTTCACAAGACATCTTTAAATGCTTATGTAAAGAGCATTGTTCAAGAGTATGTTAAGTCATCTGCTTGGGAAACA
GGAGAAAACTGCTTTATGCCTGATTGGTTTGAAGCCAAGCTTGTTTCTCTGATGGTCTTGCTGGCTGTGGATGTGGAAGGAATGAAGACT
CAGTATAGCGGAAAGCAGAGAACAGAGAATGTATTGCGGATATTCTTAGACCCTCTTCTGGATGTGCTTATGAAGTTTAGTACCAATGCC
TACATGCCCTTGCTGAAGACTGACAGATGCCTCCAGCTGCTGTTGAAGCTGTTGAACACATGCAGGTTGAAAGGTTCCAGTGCCCAAGAT
GATGAGGTGTCTACTGTTCTTCAGAACTTTTTCATGTCTACTACAGAGAGCATTTCTGAATTTATTCTCAGAAGACTTACTATGAATGAG
CTAAATAGTGTTTCAGATCTGGATCGTTGCCATTTATACCTGATGGTGTTAACTGAGCTTATAAATCTGCATTTGAAGGTTGGGTGGAAA
AGGGGTAACCCTATCTGGAGAGTTATTTCTCTTTTGAAAAATGCATCCATTCAGCATCTTCAAGAGATGGACAGTGGACAGGAGCCAACA
GTTGGAAGTCAGATTCAGAGAGTAGTGAGCATGGCTGCCTTGGCCATGGTGTGTGAGGCCATAGACCAGAAGCCTGAGCTGCAGCTGGAC
TCTCTCCATGCTGGGCCCCTGGAAAGCTTCCTTTCCTCTCTTCAGCTCAATCAGACGCTGCAGAAGCCCCACGCAGAGGAGCAGAGCAGT
TATGCTCACCCCTTGGAGTGCAGCAGTGTTTTGGAAGAATCGTCATCTTCCCAAGGATGGGGAAAAATAGTTGCACAATATATTCATGAT
CAATGGGTGTGCCTCTCTTTCCTGTTGAAAAAATATCACACCCTTATACCAACCACAGGGAGTGAAATTCTGGAACCGTTTCTACCTGCC
GTTCAGATGCCAATAAGGACTTTGCAGTCTGCACTAGAAGCCCTCACAGTTCTTTCTTCTGATCAAGTTTTACCAGTGTTCCATTGCTTG
AAAGTGTTGGTTCCCAAGCTTCTGACTTCCTCTGAATCACTCTGCATAGAGTCTTTTGACATGGCGTGGAAAATTATATCTTCTTTAAGC
AACACTCAGCTGATATTCTGGGCTAATTTAAAAGCTTTTGTTCAGTTTGTTTTTGATAACAAAGTTCTTACCATTGCTGCCAAAATCAAG
GGCCAGGCATATTTCAAAATAAAAGAGATTATGTACAAGATAATTGAAATGTCTGCTATAAAGACTGGAGTCTTCAATACACTGATAAGT
TACTGCTGTCAGTCTTGGATAGTGTCTGCTTCAAATGTGTCCCAAGGATCTTTATCAAGTGCTAAAAATTATAGCGAACTTATCCTTGAG
GCTTGTATATTTGGAACTGTGTTTAGGCGTGATCAAAGACTTGTTCAGGATGTACAGACCTTCATAGAAAACCTTGGACATGACTGTGCG
GCAAATATTGTTATGGAAAATACTAAGAGAGAAGACCATTATGTGAGAATTTGTGCTGTCAAATTCCTGTGTTTATTAGATGGCTCCAAT
ATGTCCCACAAGTTGTTTATTGAGGATCTTGCAATCAAGCTATTAGATAAAGATGAATTAGTGTCCAAGTCCAAAAAACGCTACTATGTG
AATTCTCTACAGCACAGAGTGAAAAACCGAGTGTGGCAGACTCTGCTGGTACTTTTCCCTAGACTTGACCAGAATTTCTTGAATGGAATT
ATTGACAGGATTTTCCAGGCTGGTTTCACCAACAATCAAGCATCCATAAAATATTTTATAGAATGGATTATTATATTGATTCTTCATAAA
TTCCCTCAATTTCTTCCAAAGTTCTGGGATTGTTTTTCTTATGGTGAAGAAAATCTTAAAACAAGCATTTGTACGTTTTTAGCAGTTTTA
TCACATTTAGACATTATTACTCAAAATATTCCAGAAAAGAAACTAATTCTGAAGCAAGCCCTTATAGTTGTGCTGCAGTGGTGTTTCAAT
CACAATTTTAGTGTTCGACTGTATGCTTTAGTTGCTCTTAAGAAACTCTGGACTGTGTGTAAAGTGTTAAGTGTTGAAGAATTTGATGCC
CTGACTCCTGTGATTGAATCCAGCCTCCATCAAGTGGAAAGCATGCACGGAGCAGGGAATGCCAAGAAGAATTGGCAACGCATTCAGGAG
CATTTCTTTTTTGCAACATTTCACCCACTCAAGGATTATTGTCTAGAGACCATATTTTACATCCTTCCACGCCTTTCAGGCCTTATTGAA
GATGAATGGATCACCATTGATAAATTTACCAGATTCACTGATGTTCCTTTAGCTGCGGGATTTCAGTGGTACCTTTCTCAAACTCAACTT
AGTAAACTAAAACCAGGTGACTGGTCTCAGCAAGACATAGGTACTAATTTGGTCGAAGCAGATAACCAAGCGGAGTGGACCGACGTTCAG
AAGAAGATTATCCCGTGGAACAGTCGTGTTTCCGACTTAGACCTGGAGCTCCTGTTTCAGGATCGTGCTGCCAGACTTGGAAAGTCAATT
AGTAGACTCATCGTTGTGGCCTCGCTCATCGACAAACCGACCAATTTAGGAGGACTGTGCAGGACCTGTGAGGTATTTGGGGCTTCAGTG
CTCGTTGTTGGCAGCCTTCAGTGTATCAGCGACAAACAGTTTCAGCACCTCAGTGTCTCTGCAGAACAGTGGCTTCCTCTAGTGGAGGTA
AAACCACCTCAGCTAATTGATTATCTGCAGCAGAAGAAAACAGAAGGTTATACCATCATTGGAGTGGAACAAACTGCCAAAAGTTTAGAC
CTAACCCAATATTGCTTTCCTGAGAAATCTCTGCTCTTGTTGGGAAATGAACGTGAGGGAATTCCAGCAAATCTGATCCAACAGTTGGAC
GTTTGTGTGGAAATTCCTCAACAGGGCATTATCCGCTCCCTGAATGTCCATGTGAGTGGAGCCCTGCTGATCTGGGAGTACACCAGGCAG
CAGCTGCTCTCGCACGGAGATACCAAGCCATGATGTGCCTTCCTTAGTGAACTGCTGCTGCTGTTCAGACTTTTTTAAAAAAAACTATTT
GGACTAAAGAAACAGATTCTGAAATTTATTGTGATAATTTGTATTTCTTTTTTCTTGCAATTTAATGCCAAAAGTTTGCCATGTGCCTTA
AACATATTACTATATATTTTCCCCTTTAATAAACACTTTTTGTTAAATTGTATTCTTCCTTTAATAAAATATTTTAAGCAATTGTGGAAA

>35368_35368_3_GUK1-TARBP1_GUK1_chr1_228328064_ENST00000391865_TARBP1_chr1_234603396_ENST00000040877_length(amino acids)=1288AA_BP=33
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGCWLFHPSWHMCIYKRMFESENKILSKEGVIHFLELYETKILPFSPEFSEFIIGPLM
DALSESSLYSRSPGQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSFLLKFIRKMTSRHWCAVPILFLSKALANVPRHKALGIDGLLALRD
VIHCTMITHQILLRGAAQCYLLQTAMNLLDVEKVSLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKTSLN
AYVKSIVQEYVKSSAWETGENCFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTENVLRIFLDPLLDVLMKFSTNAYMPLLKTDRCLQ
LLLKLLNTCRLKGSSAQDDEVSTVLQNFFMSTTESISEFILRRLTMNELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVISLL
KNASIQHLQEMDSGQEPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLESFLSSLQLNQTLQKPHAEEQSSYAHPLECSSVLE
ESSSSQGWGKIVAQYIHDQWVCLSFLLKKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLTSSE
SLCIESFDMAWKIISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKEIMYKIIEMSAIKTGVFNTLISYCCQSWIVSASN
VSQGSLSSAKNYSELILEACIFGTVFRRDQRLVQDVQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIEDLAI
KLLDKDELVSKSKKRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGFTNNQASIKYFIEWIIILILHKFPQFLPKFWDCF
SYGEENLKTSICTFLAVLSHLDIITQNIPEKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSLHQV
ESMHGAGNAKKNWQRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITIDKFTRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQD
IGTNLVEADNQAEWTDVQKKIIPWNSRVSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDK
QFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GUK1-TARBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GUK1-TARBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GUK1-TARBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource