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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GXYLT2-NEK3 (FusionGDB2 ID:35416)

Fusion Gene Summary for GXYLT2-NEK3

check button Fusion gene summary
Fusion gene informationFusion gene name: GXYLT2-NEK3
Fusion gene ID: 35416
HgeneTgene
Gene symbol

GXYLT2

NEK3

Gene ID

727936

4752

Gene nameglucoside xylosyltransferase 2NIMA related kinase 3
SynonymsGLT8D4HSPK36
Cytomap

3p13

13q14.3

Type of geneprotein-codingprotein-coding
Descriptionglucoside xylosyltransferase 2glycosyltransferase 8 domain containing 4glycosyltransferase 8 domain-containing protein 4serine/threonine-protein kinase Nek3HSPK 36NIMA (never in mitosis gene a)-related kinase 3glycogen synthase A kinasehydroxyalkyl-protein kinasenever in mitosis A-related kinase 3nimA-related protein kinase 3phosphorylase B kinase kinase
Modification date2020031320200313
UniProtAcc

A0PJZ3

P51956

Ensembl transtripts involved in fusion geneENST00000389617, ENST00000339406, 
ENST00000378101, ENST00000400357, 
ENST00000452082, 
Fusion gene scores* DoF score7 X 5 X 5=1751 X 1 X 1=1
# samples 71
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: GXYLT2 [Title/Abstract] AND NEK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEK3(52722550)-GXYLT2(73006380), # samples:3
GXYLT2(72971486)-NEK3(52719026), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGXYLT2

GO:0016266

O-glycan processing

19940119


check buttonFusion gene breakpoints across GXYLT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NEK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A44R-06AGXYLT2chr3

72971486

-NEK3chr13

52719026

-
ChimerDB4SKCMTCGA-EB-A44R-06AGXYLT2chr3

72971486

+NEK3chr13

52719026

-


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Fusion Gene ORF analysis for GXYLT2-NEK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389617ENST00000339406GXYLT2chr3

72971486

+NEK3chr13

52719026

-
In-frameENST00000389617ENST00000378101GXYLT2chr3

72971486

+NEK3chr13

52719026

-
In-frameENST00000389617ENST00000400357GXYLT2chr3

72971486

+NEK3chr13

52719026

-
In-frameENST00000389617ENST00000452082GXYLT2chr3

72971486

+NEK3chr13

52719026

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389617GXYLT2chr372971486+ENST00000378101NEK3chr1352719026-2178761801678532
ENST00000389617GXYLT2chr372971486+ENST00000339406NEK3chr1352719026-2178761801678532
ENST00000389617GXYLT2chr372971486+ENST00000452082NEK3chr1352719026-2119761801627515
ENST00000389617GXYLT2chr372971486+ENST00000400357NEK3chr1352719026-2119761801627515

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389617ENST00000378101GXYLT2chr372971486+NEK3chr1352719026-0.0032793460.9967206
ENST00000389617ENST00000339406GXYLT2chr372971486+NEK3chr1352719026-0.0032793460.9967206
ENST00000389617ENST00000452082GXYLT2chr372971486+NEK3chr1352719026-0.0037101280.99628985
ENST00000389617ENST00000400357GXYLT2chr372971486+NEK3chr1352719026-0.0037101280.99628985

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Fusion Genomic Features for GXYLT2-NEK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GXYLT2-NEK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52722550/chr13:73006380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GXYLT2

A0PJZ3

NEK3

P51956

FUNCTION: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. {ECO:0000269|PubMed:19940119}.FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGXYLT2chr3:72971486chr13:52719026ENST00000389617+3768_98200444.0Compositional biasNote=Arg-rich
HgeneGXYLT2chr3:72971486chr13:52719026ENST00000389617+371_4200444.0Topological domainCytoplasmic
HgeneGXYLT2chr3:72971486chr13:52719026ENST00000389617+375_25200444.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGXYLT2chr3:72971486chr13:52719026ENST00000389617+3726_443200444.0Topological domainLumenal
TgeneNEK3chr3:72971486chr13:52719026ENST000004003576144_257201490.0DomainProtein kinase
TgeneNEK3chr3:72971486chr13:52719026ENST0000040035761410_18201490.0Nucleotide bindingATP


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Fusion Gene Sequence for GXYLT2-NEK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35416_35416_1_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000339406_length(transcript)=2178nt_BP=761nt
GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT
CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG
CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG
CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG
TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC
CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA
TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT
TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA
AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT
GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG
CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT
TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAAGCAAACCCCAGCAGAATCAGGATAGCTTTGGGAAATGAAGCAAGCA
CAGTGCAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAG
TAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTAC
CCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGT
ACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTT
TTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATG
GAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACC
CCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCGACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGA
GGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGACGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAA
CTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCTAGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTAT
AGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGGGATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGA
AATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATAATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTT
ATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATGTGACTCTTTTTACATTTCCTAAAGGTTTGAGAATTAAAT

>35416_35416_1_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000339406_length(amino acids)=532AA_BP=222
MLHSSCRRRDAQRGRAAWGPPPPPRRTMKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGA
SPGVRRRRPPRPRPRAGRRGAARLEKLARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEF
DKQLRQWPDSYTKKFEHRIYPITFSVGNPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSH
RPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKANPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESA
LRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADL

--------------------------------------------------------------
>35416_35416_2_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000378101_length(transcript)=2178nt_BP=761nt
GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT
CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG
CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG
CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG
TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC
CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA
TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT
TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA
AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT
GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG
CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT
TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAAGCAAACCCCAGCAGAATCAGGATAGCTTTGGGAAATGAAGCAAGCA
CAGTGCAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAAGCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAG
TAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTTCACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTAC
CCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTTTAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGT
ACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTTTGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTT
TTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCCCCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATG
GAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAGATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACC
CCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCGACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGA
GGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGACGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAA
CTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCTAGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTAT
AGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGGGATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGA
AATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATAATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTT
ATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATGTGACTCTTTTTACATTTCCTAAAGGTTTGAGAATTAAAT

>35416_35416_2_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000378101_length(amino acids)=532AA_BP=222
MLHSSCRRRDAQRGRAAWGPPPPPRRTMKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGA
SPGVRRRRPPRPRPRAGRRGAARLEKLARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEF
DKQLRQWPDSYTKKFEHRIYPITFSVGNPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSH
RPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKANPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESA
LRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADL

--------------------------------------------------------------
>35416_35416_3_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000400357_length(transcript)=2119nt_BP=761nt
GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT
CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG
CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG
CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG
TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC
CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA
TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT
TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA
AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT
GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG
CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT
TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAACAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAA
GCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTT
CACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTT
TAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTT
TGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCC
CCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAG
ATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACCCCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCG
ACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGAGGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGA
CGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAACTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCT
AGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTATAGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGG
GATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGAAATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATA
ATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTTATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATG

>35416_35416_3_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000400357_length(amino acids)=515AA_BP=222
MLHSSCRRRDAQRGRAAWGPPPPPRRTMKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGA
SPGVRRRRPPRPRPRAGRRGAARLEKLARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEF
DKQLRQWPDSYTKKFEHRIYPITFSVGNPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSH
RPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLR
KASSPNLHRRQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGF

--------------------------------------------------------------
>35416_35416_4_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000452082_length(transcript)=2119nt_BP=761nt
GTCGCCGCCGCCGCCGGCCGCCCGCCGGCCGCCACGACCCCAGTCCCCGGCGGGCGGGCGGAGGAGGCGACCGCCGCGCGCTGCTGCACT
CATCCTGCCGCCGCCGCGATGCGCAGAGGGGCCGAGCCGCCTGGGGGCCGCCGCCGCCGCCGCGCCGCACCATGAAGCTCCGCAGCAAGG
CGGCGGCGCTGCTCTTGCTCGCGCTGGCCGCGCTGCTGCTGGCGCTGCTGTCCCTGCGCGCTGGCCGCGCTGAGCCCCCAGCGCTGCCCG
CGCGCCCCGCGTCCGCCCCGCAGCGCCACCCCGCGCCTGTCCCCGCGCGCTGGCCGGGGCCGGGCGCCCTCCCCGGGGCCAGCCCGGGAG
TTCGGAGGCGCCGGCCCCCGCGTCCGCGCCCCCGAGCGGGCCGCCGGGGCGCTGCGAGACTGGAGAAGTTGGCGAGGAGGCCTGGAGAAC
CCAGGAGTTTCCAAGCTGTGCTGCCACCCGAGCTCTGGATCCACCTGGCTGTGGTGGCCTGTGGCAATCGGCTGGAGGAGACGCTGGTCA
TGCTCAAATCAGCTGTGCTTTTTAGCCACAGGAAGATCCAATTCCACATCTTCACTGAAGACTCTCTGAAGCCCGAGTTTGATAAGCAGT
TACGCCAGTGGCCTGACTCATATACAAAGAAGTTTGAGCACAGAATCTACCCCATCACATTTTCTGTTGGAAACCCTCAGGAGTGGAAGA
AATTGTTCAAACCCTGTGCTGCCCAGAGACTCTTTCTTCCGTTTCAGGCAAATAGTTGGAAAAATCTTATCCTCAAAGTATGTCAAGGGT
GCATCAGTCCACTGCCGTCTCATTACTCCTATGAACTTCAGTTCCTAGTCAAGCAGATGTTTAAAAGGAATCCCTCACATCGCCCCTCGG
CTACAACGCTTCTCTCTCGAGGCATCGTAGCTCGGCTTGTCCAGAAGTGCTTACCCCCCGAGATCATCATGGAATATGGTGAGGAAGTAT
TAGAAGAAATAAAAAATTCGAAGCATAACACACCAAGAAAAAAACAAGAGGAAGAACAAGATAGAAAGGGTAGCCATACTGATTTGGAAA
GCATTAATGAAAATTTAGTTGAAAGTGCATTGAGAAGAGTAAACAGAGAAGAAAAAGGTAATAAGTCAGTCCATCTGAGGAAAGCCAGTT
CACCAAATCTTCATAGACGACAGTGGGAGAAAAATGTACCCAATACAGCTCTTACAGCTTTGGAAAATGCATCCATACTCACCTCCAGTT
TAACAGCAGAGGACGATAGAGGTGGTTCTGTAATAAAGTACAGCAAAAATACTACTCGTAAGCAGTGGCTCAAAGAGACCCCTGACACTT
TGTTGAACATCCTTAAGAATGCTGATCTCAGCTTGGCTTTTCAAACATACACAATATATAGACCAGGTTCAGAAGGGTTCTTGAAAGGCC
CCCTGTCTGAAGAAACAGAAGCATCGGACAGTGTTGATGGAGGTCACGATTCTGTCATTTTGGATCCAGAGCGACTTGAGCCTGGGCTAG
ATGAGGAGGACACGGACTTTGAGGAGGAAGATGACAACCCCGACTGGGTGTCAGAGCTGAAGAAGCGAGCTGGATGGCAAGGCCTGTGCG
ACAGATAATGCCTGAGGAAATGTTCCTGAGTCACGCTGAGGAGAGGCTTCACTCAGGAGTTCATGCTGAGATGATCATGAGTTCATGCGA
CGTATATTTTCCTTTGGAAACAGAATGAAGCAGAGGAAACTCTTAATACTTAAAATCGTTCTTGATTAGTATCGTGAGTTTGAAAAGTCT
AGAACTCCTGTAAGTTTTTGAACTCAAGGGAGAAGGTATAGTGGAATGAGTGTGAGCATCGGGCTTTGCAGTCCCATAGAACAGAAATGG
GATGCTAGCGTGCCACTACCTACTTGTGTGATTGTGGGAAATTACTTAACCTCTTCAAGCCCCAATTTCCTCAACCATAAAATGAAGATA
ATAATGCCTACCTCAGAGGGATGCTGACCACAGACCTTTATAGCAGCCCGTATGATATTATTCACATTATGATATGTGTTTATTATTATG

>35416_35416_4_GXYLT2-NEK3_GXYLT2_chr3_72971486_ENST00000389617_NEK3_chr13_52719026_ENST00000452082_length(amino acids)=515AA_BP=222
MLHSSCRRRDAQRGRAAWGPPPPPRRTMKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGA
SPGVRRRRPPRPRPRAGRRGAARLEKLARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEF
DKQLRQWPDSYTKKFEHRIYPITFSVGNPQEWKKLFKPCAAQRLFLPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSH
RPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLR
KASSPNLHRRQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGF

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Fusion Gene PPI Analysis for GXYLT2-NEK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNEK3chr3:72971486chr13:52719026ENST000004003576141_285201.0490.0VAV2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GXYLT2-NEK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GXYLT2-NEK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource