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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GYS1-EML2 (FusionGDB2 ID:35427)

Fusion Gene Summary for GYS1-EML2

Fusion gene summary

Fusion gene information	Fusion gene name: GYS1-EML2
	Fusion gene ID: 35427
		Hgene	Tgene
	Gene symbol	GYS1	EML2
	Gene ID	2997	24139
	Gene name	glycogen synthase 1	EMAP like 2
	Synonyms	GSY\|GYS	ELP70\|EMAP-2\|EMAP2
	Cytomap	19q13.33	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	glycogen [starch] synthase, muscleglycogen synthase 1 (muscle)	echinoderm microtubule-associated protein-like 2echinoderm MT-associated protein (EMAP)-like protein 70echinoderm microtubule associated protein like 2microtubule-associated protein like echinoderm EMAP
	Modification date	20200313	20200313
	UniProtAcc	P13807	O95834
	Ensembl transtripts involved in fusion gene	ENST00000263276, ENST00000323798, ENST00000540532, ENST00000541188, ENST00000544287, ENST00000457974,	ENST00000586902, ENST00000245925, ENST00000536630, ENST00000587152, ENST00000589876,
Fusion gene scores	* DoF score	9 X 10 X 7=630	9 X 8 X 6=432
	# samples	10	10
	** MAII score	log2(10/630*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GYS1 [Title/Abstract] AND EML2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GYS1(49485512)-EML2(46116929), # samples:3
Anticipated loss of major functional domain due to fusion event.	GYS1-EML2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GYS1-EML2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GYS1	GO:0005978	glycogen biosynthetic process	16275910
Tgene	EML2	GO:0010968	regulation of microtubule nucleation	11694528
Tgene	EML2	GO:0031115	negative regulation of microtubule polymerization	11694528

Fusion gene breakpoints across GYS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EML2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1F6-01A	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
ChimerDB4	BRCA	TCGA-BH-A1F6-01A	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
ChimerDB4	BRCA	TCGA-BH-A1F6	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
ChimerDB4	BRCA	TCGA-BH-A1F6	GYS1	chr19	49488717	-	EML2	chr19	46116929	-

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Fusion Gene ORF analysis for GYS1-EML2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000263276	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5CDS-intron	ENST00000263276	ENST00000586902	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000263276	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000263276	ENST00000586902	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000323798	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5CDS-intron	ENST00000323798	ENST00000586902	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000323798	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000323798	ENST00000586902	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000540532	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5CDS-intron	ENST00000540532	ENST00000586902	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000540532	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000540532	ENST00000586902	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000541188	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5CDS-intron	ENST00000541188	ENST00000586902	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000541188	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5CDS-intron	ENST00000541188	ENST00000586902	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5UTR-3CDS	ENST00000544287	ENST00000245925	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5UTR-3CDS	ENST00000544287	ENST00000536630	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5UTR-3CDS	ENST00000544287	ENST00000587152	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5UTR-3CDS	ENST00000544287	ENST00000589876	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5UTR-3CDS	ENST00000544287	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
5UTR-intron	ENST00000544287	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
5UTR-intron	ENST00000544287	ENST00000586902	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
5UTR-intron	ENST00000544287	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000263276	ENST00000245925	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000263276	ENST00000536630	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000263276	ENST00000587152	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000263276	ENST00000589876	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000263276	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000323798	ENST00000245925	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000323798	ENST00000536630	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000323798	ENST00000587152	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000323798	ENST00000589876	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000323798	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000540532	ENST00000245925	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000540532	ENST00000536630	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000540532	ENST00000587152	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000540532	ENST00000589876	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000540532	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000541188	ENST00000245925	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000541188	ENST00000536630	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000541188	ENST00000587152	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
Frame-shift	ENST00000541188	ENST00000589876	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
Frame-shift	ENST00000541188	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
In-frame	ENST00000263276	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000263276	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000263276	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000263276	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000323798	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000323798	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000323798	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000323798	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000541188	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000541188	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000541188	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
In-frame	ENST00000541188	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
intron-3CDS	ENST00000457974	ENST00000245925	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000245925	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
intron-3CDS	ENST00000457974	ENST00000536630	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000536630	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
intron-3CDS	ENST00000457974	ENST00000587152	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000587152	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
intron-3CDS	ENST00000457974	ENST00000589876	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000589876	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000457974	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000544287	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000544287	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000544287	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-3CDS	ENST00000544287	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-intron	ENST00000457974	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116928	-
intron-intron	ENST00000457974	ENST00000586902	GYS1	chr19	49485512	-	EML2	chr19	46116929	-
intron-intron	ENST00000457974	ENST00000586902	GYS1	chr19	49485511	-	EML2	chr19	46116929	-
intron-intron	ENST00000457974	ENST00000586902	GYS1	chr19	49488717	-	EML2	chr19	46116929	-
intron-intron	ENST00000544287	ENST00000586902	GYS1	chr19	49488717	-	EML2	chr19	46116929	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000323798	GYS1	chr19	49488717	-	ENST00000589876	EML2	chr19	46116929	-	1664	1020	20	1648	542
ENST00000323798	GYS1	chr19	49488717	-	ENST00000245925	EML2	chr19	46116929	-	1540	1020	20	1276	418
ENST00000323798	GYS1	chr19	49488717	-	ENST00000536630	EML2	chr19	46116929	-	1538	1020	20	1276	418
ENST00000323798	GYS1	chr19	49488717	-	ENST00000587152	EML2	chr19	46116929	-	1302	1020	20	1276	418
ENST00000263276	GYS1	chr19	49488717	-	ENST00000589876	EML2	chr19	46116929	-	1473	829	21	1457	478
ENST00000263276	GYS1	chr19	49488717	-	ENST00000245925	EML2	chr19	46116929	-	1349	829	21	1085	354
ENST00000263276	GYS1	chr19	49488717	-	ENST00000536630	EML2	chr19	46116929	-	1347	829	21	1085	354
ENST00000263276	GYS1	chr19	49488717	-	ENST00000587152	EML2	chr19	46116929	-	1111	829	21	1085	354
ENST00000541188	GYS1	chr19	49488717	-	ENST00000589876	EML2	chr19	46116929	-	1482	838	255	1466	403
ENST00000541188	GYS1	chr19	49488717	-	ENST00000245925	EML2	chr19	46116929	-	1358	838	255	1094	279
ENST00000541188	GYS1	chr19	49488717	-	ENST00000536630	EML2	chr19	46116929	-	1356	838	255	1094	279
ENST00000541188	GYS1	chr19	49488717	-	ENST00000587152	EML2	chr19	46116929	-	1120	838	255	1094	279

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000323798	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.1126186	0.8873814
ENST00000323798	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.003043407	0.9969566
ENST00000323798	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.003054096	0.9969459
ENST00000323798	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.005851355	0.9941486
ENST00000263276	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.15398596	0.846014
ENST00000263276	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.002861453	0.9971386
ENST00000263276	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.002884195	0.99711585
ENST00000263276	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.005373898	0.9946261
ENST00000541188	ENST00000589876	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.6520698	0.3479302
ENST00000541188	ENST00000245925	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.09016043	0.9098396
ENST00000541188	ENST00000536630	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.0890618	0.91093826
ENST00000541188	ENST00000587152	GYS1	chr19	49488717	-	EML2	chr19	46116929	-	0.15665804	0.843342

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Fusion Genomic Features for GYS1-EML2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GYS1-EML2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49485512/chr19:46116929)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GYS1 P13807	EML2 O95834
FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.	FUNCTION: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. {ECO:0000269\|PubMed:11694528}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

564_602

564

650.0

Repeat

Note=WD 11

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

609_648

564

650.0

Repeat

Note=WD 12

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

10_649

564

650.0

Region

Tandem atypical propeller in EMLs

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

10_649

711

797.0

Region

Tandem atypical propeller in EMLs

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

10_649

765

851.0

Region

Tandem atypical propeller in EMLs

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

151_192

564

650.0

Repeat

Note=WD 3

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

195_234

564

650.0

Repeat

Note=WD 4

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

241_280

564

650.0

Repeat

Note=WD 5

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

285_323

564

650.0

Repeat

Note=WD 6

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

369_406

564

650.0

Repeat

Note=WD 7

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

410_447

564

650.0

Repeat

Note=WD 8

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

452_489

564

650.0

Repeat

Note=WD 9

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

495_535

564

650.0

Repeat

Note=WD 10

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

56_93

564

650.0

Repeat

Note=WD 1

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000245925

97_144

564

650.0

Repeat

Note=WD 2

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

151_192

711

797.0

Repeat

Note=WD 3

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

195_234

711

797.0

Repeat

Note=WD 4

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

241_280

711

797.0

Repeat

Note=WD 5

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

285_323

711

797.0

Repeat

Note=WD 6

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

369_406

711

797.0

Repeat

Note=WD 7

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

410_447

711

797.0

Repeat

Note=WD 8

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

452_489

711

797.0

Repeat

Note=WD 9

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

495_535

711

797.0

Repeat

Note=WD 10

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

564_602

711

797.0

Repeat

Note=WD 11

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

56_93

711

797.0

Repeat

Note=WD 1

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

609_648

711

797.0

Repeat

Note=WD 12

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000536630

97_144

711

797.0

Repeat

Note=WD 2

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

151_192

765

851.0

Repeat

Note=WD 3

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

195_234

765

851.0

Repeat

Note=WD 4

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

241_280

765

851.0

Repeat

Note=WD 5

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

285_323

765

851.0

Repeat

Note=WD 6

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

369_406

765

851.0

Repeat

Note=WD 7

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

410_447

765

851.0

Repeat

Note=WD 8

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

452_489

765

851.0

Repeat

Note=WD 9

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

495_535

765

851.0

Repeat

Note=WD 10

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

564_602

765

851.0

Repeat

Note=WD 11

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

56_93

765

851.0

Repeat

Note=WD 1

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

609_648

765

851.0

Repeat

Note=WD 12

Tgene

EML2

chr19:49488717

chr19:46116929

ENST00000587152

97_144

765

851.0

Repeat

Note=WD 2

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Fusion Gene Sequence for GYS1-EML2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>35427_35427_1_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000245925_length(transcript)=1349nt_BP=829nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTGGTTGCTCAC
TTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCATGCCACGCTG
CTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAGAGGCAGATC
TACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAGGCACAGCAC
TTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGGAAGTTGCTG
GCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACGGTGGACACAGC
AGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTACAGTGGCGGGTG
GTCTGATGCGGCCAGGGAAGAGTCAGGTGTCAGGGCAGGAATTCTATTTTCGGGAGATGTCTATTGCCGAGTAGAGTAATATATACCCAG
AGTATGTCTATAGCAGAGGGGGTTATGGGGGCGGGAGGGTAGACTGACATACAGAAGTCTCTATTTATCCGGGTGGGAAGAGGGAGTCAC

>35427_35427_1_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000245925_length(amino acids)=354AA_BP=269
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFLAQSEEKPHVVAHFHEWLAG
VGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPG

--------------------------------------------------------------
>35427_35427_2_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000536630_length(transcript)=1347nt_BP=829nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTGGTTGCTCAC
TTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCATGCCACGCTG
CTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAGAGGCAGATC
TACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAGGCACAGCAC
TTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGGAAGTTGCTG
GCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACGGTGGACACAGC
AGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTACAGTGGCGGGTG
GTCTGATGCGGCCAGGGAAGAGTCAGGTGTCAGGGCAGGAATTCTATTTTCGGGAGATGTCTATTGCCGAGTAGAGTAATATATACCCAG
AGTATGTCTATAGCAGAGGGGGTTATGGGGGCGGGAGGGTAGACTGACATACAGAAGTCTCTATTTATCCGGGTGGGAAGAGGGAGTCAC

>35427_35427_2_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000536630_length(amino acids)=354AA_BP=269
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFLAQSEEKPHVVAHFHEWLAG
VGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPG

--------------------------------------------------------------
>35427_35427_3_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000587152_length(transcript)=1111nt_BP=829nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTGGTTGCTCAC
TTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCATGCCACGCTG
CTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAGAGGCAGATC
TACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAGGCACAGCAC
TTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGGAAGTTGCTG
GCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACGGTGGACACAGC
AGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTACAGTGGCGGGTG

>35427_35427_3_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000587152_length(amino acids)=354AA_BP=269
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFLAQSEEKPHVVAHFHEWLAG
VGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPG

--------------------------------------------------------------
>35427_35427_4_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000589876_length(transcript)=1473nt_BP=829nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTGGTTGCTCAC
TTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCATGCCACGCTG
CTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAGAGGCAGATC
TACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAGGCACAGCAC
TTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGGAAGTTGCTG
GCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGTTCTGGGAAAGTGGCCCAGCGCTGCGGAA
GCGGCCCTTTCATCGGGCATCCGGGTGCTCTTTCGACCCCTCGTGGCCAGTCTTGGACCTGCATGGAAAAATGTGCCAAGAAAGTTCTGC
TGGAAAAGTGCTGGTGATTCTCCACGTGACCCTCCTCCGCGCCCCCAGGGTCACTCTCAGCCTTCCTTCCCCAGCTCGGGGCCCTGGGAG
ACCGCCGTGTGCAAATTCTATCGGCAGGGTCGGTGGAGAGAGGTCAGGGTATTTGCTTCCTGGGCCCCTCCCTGCATCCCGCACTCACAG
TGGCTGTGGTTCCCCTCCTCTGAGCCGCAGTTCCTCTGGGAACTCGAGCTGTCCCTGGAGACGGGTAACAGACTCCCTCCCTGTCCCTTC
TGCCCTAGGCTGGCGATGGCTTCGTGCCCACTTCGGATGGTCCCCTGGGGCCGCCCCATCCTTTGTGGCTTTCTCCACTCTGCCCATCCC

>35427_35427_4_GYS1-EML2_GYS1_chr19_49488717_ENST00000263276_EML2_chr19_46116929_ENST00000589876_length(amino acids)=478AA_BP=269
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFLAQSEEKPHVVAHFHEWLAG
VGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPG
IWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRVLGKWPSAAEAALSSGIRVLFRPLVASLGPAWKNVPRKFCWKSAGDS
PRDPPPRPQGHSQPSFPSSGPWETAVCKFYRQGRWREVRVFASWAPPCIPHSQWLWFPSSEPQFLWELELSLETGNRLPPCPFCPRLAMA

--------------------------------------------------------------
>35427_35427_5_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000245925_length(transcript)=1540nt_BP=1020nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGG
TGCTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACG
ACCGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATG
TGGTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCC
ATGCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGG
AGAGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCG
AGGCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATG
GGAAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACG
GTGGACACAGCAGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTAC
AGTGGCGGGTGGTCTGATGCGGCCAGGGAAGAGTCAGGTGTCAGGGCAGGAATTCTATTTTCGGGAGATGTCTATTGCCGAGTAGAGTAA
TATATACCCAGAGTATGTCTATAGCAGAGGGGGTTATGGGGGCGGGAGGGTAGACTGACATACAGAAGTCTCTATTTATCCGGGTGGGAA
GAGGGAGTCACATCGCTTTGGGGATCCATTGGTGTTTGGTTTGGGGTGTTTTTTAAGTTTTTTCTTTTATATCATCCAGAAATAAAGACA

>35427_35427_5_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000245925_length(amino acids)=418AA_BP=333
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGA
SAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGR
YLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASA

--------------------------------------------------------------
>35427_35427_6_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000536630_length(transcript)=1538nt_BP=1020nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGG
TGCTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACG
ACCGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATG
TGGTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCC
ATGCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGG
AGAGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCG
AGGCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATG
GGAAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACG
GTGGACACAGCAGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTAC
AGTGGCGGGTGGTCTGATGCGGCCAGGGAAGAGTCAGGTGTCAGGGCAGGAATTCTATTTTCGGGAGATGTCTATTGCCGAGTAGAGTAA
TATATACCCAGAGTATGTCTATAGCAGAGGGGGTTATGGGGGCGGGAGGGTAGACTGACATACAGAAGTCTCTATTTATCCGGGTGGGAA
GAGGGAGTCACATCGCTTTGGGGATCCATTGGTGTTTGGTTTGGGGTGTTTTTTAAGTTTTTTCTTTTATATCATCCAGAAATAAAGACA

>35427_35427_6_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000536630_length(amino acids)=418AA_BP=333
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGA
SAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGR
YLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASA

--------------------------------------------------------------
>35427_35427_7_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000587152_length(transcript)=1302nt_BP=1020nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGG
TGCTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACG
ACCGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATG
TGGTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCC
ATGCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGG
AGAGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCG
AGGCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATG
GGAAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACG
GTGGACACAGCAGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTAC

>35427_35427_7_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000587152_length(amino acids)=418AA_BP=333
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGA
SAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGR
YLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASA

--------------------------------------------------------------
>35427_35427_8_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000589876_length(transcript)=1664nt_BP=1020nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGG
TGCTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACG
ACCGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATG
TGGTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCC
ATGCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGG
AGAGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCG
AGGCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATG
GGAAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGTTCTGGGAAAGTGGCCCA
GCGCTGCGGAAGCGGCCCTTTCATCGGGCATCCGGGTGCTCTTTCGACCCCTCGTGGCCAGTCTTGGACCTGCATGGAAAAATGTGCCAA
GAAAGTTCTGCTGGAAAAGTGCTGGTGATTCTCCACGTGACCCTCCTCCGCGCCCCCAGGGTCACTCTCAGCCTTCCTTCCCCAGCTCGG
GGCCCTGGGAGACCGCCGTGTGCAAATTCTATCGGCAGGGTCGGTGGAGAGAGGTCAGGGTATTTGCTTCCTGGGCCCCTCCCTGCATCC
CGCACTCACAGTGGCTGTGGTTCCCCTCCTCTGAGCCGCAGTTCCTCTGGGAACTCGAGCTGTCCCTGGAGACGGGTAACAGACTCCCTC
CCTGTCCCTTCTGCCCTAGGCTGGCGATGGCTTCGTGCCCACTTCGGATGGTCCCCTGGGGCCGCCCCATCCTTTGTGGCTTTCTCCACT

>35427_35427_8_GYS1-EML2_GYS1_chr19_49488717_ENST00000323798_EML2_chr19_46116929_ENST00000589876_length(amino acids)=542AA_BP=333
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGA
SAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGR
YLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASA
DDFGKVHLFSYPCCQPRVLGKWPSAAEAALSSGIRVLFRPLVASLGPAWKNVPRKFCWKSAGDSPRDPPPRPQGHSQPSFPSSGPWETAV
CKFYRQGRWREVRVFASWAPPCIPHSQWLWFPSSEPQFLWELELSLETGNRLPPCPFCPRLAMASCPLRMVPWGRPILCGFLHSAHPSIN

--------------------------------------------------------------
>35427_35427_9_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000245925_length(transcript)=1358nt_BP=838nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGGTG
CTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACGAC
CGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTG
GTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCAT
GCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAG
AGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAG
GCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGG
AAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACGGT
GGACACAGCAGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTACAG
TGGCGGGTGGTCTGATGCGGCCAGGGAAGAGTCAGGTGTCAGGGCAGGAATTCTATTTTCGGGAGATGTCTATTGCCGAGTAGAGTAATA
TATACCCAGAGTATGTCTATAGCAGAGGGGGTTATGGGGGCGGGAGGGTAGACTGACATACAGAAGTCTCTATTTATCCGGGTGGGAAGA
GGGAGTCACATCGCTTTGGGGATCCATTGGTGTTTGGTTTGGGGTGTTTTTTAAGTTTTTTCTTTTATATCATCCAGAAATAAAGACACG

>35427_35427_9_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000245925_length(amino acids)=279AA_BP=194
MNSTWRTQCSSKWPGRWLTRVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSE
EKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQ
ITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKD

--------------------------------------------------------------
>35427_35427_10_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000536630_length(transcript)=1356nt_BP=838nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGGTG
CTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACGAC
CGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTG
GTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCAT
GCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAG
AGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAG
GCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGG
AAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACGGT
GGACACAGCAGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTACAG
TGGCGGGTGGTCTGATGCGGCCAGGGAAGAGTCAGGTGTCAGGGCAGGAATTCTATTTTCGGGAGATGTCTATTGCCGAGTAGAGTAATA
TATACCCAGAGTATGTCTATAGCAGAGGGGGTTATGGGGGCGGGAGGGTAGACTGACATACAGAAGTCTCTATTTATCCGGGTGGGAAGA
GGGAGTCACATCGCTTTGGGGATCCATTGGTGTTTGGTTTGGGGTGTTTTTTAAGTTTTTTCTTTTATATCATCCAGAAATAAAGACACG

>35427_35427_10_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000536630_length(amino acids)=279AA_BP=194
MNSTWRTQCSSKWPGRWLTRVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSE
EKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQ
ITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKD

--------------------------------------------------------------
>35427_35427_11_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000587152_length(transcript)=1120nt_BP=838nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGGTG
CTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACGAC
CGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTG
GTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCAT
GCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAG
AGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAG
GCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGG
AAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGCCCTCAGCCACAAGTACGGT
GGACACAGCAGCCATGTGACAAATGTGGCCTTCTTGTGGGATGACAGCATGGCCCTGACCACAGGGGGCAAGGACACCAGTGTGCTACAG

>35427_35427_11_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000587152_length(amino acids)=279AA_BP=194
MNSTWRTQCSSKWPGRWLTRVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSE
EKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQ
ITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKD

--------------------------------------------------------------
>35427_35427_12_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000589876_length(transcript)=1482nt_BP=838nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGGTGTATTTCGGGCGCTGGCTGATCGAGGGAGGCCCTCTGGTGGTG
CTCCTGGACGTGGGTGCCTCAGCTTGGGCCCTGGAGCGCTGGAAGGGAGAGCTCTGGGATACCTGCAACATCGGAGTGCCGTGGTACGAC
CGCGAGGCCAACGACGCTGTCCTCTTTGGCTTTCTGACCACCTGGTTCCTGGGTGAGTTCCTGGCACAGAGTGAGGAGAAGCCACATGTG
GTTGCTCACTTCCATGAGTGGTTGGCAGGCGTTGGACTCTGCCTGTGTCGTGCCCGGCGACTGCCTGTAGCAACCATCTTCACCACCCAT
GCCACGCTGCTGGGGCGCTACCTGTGTGCCGGTGCCGTGGACTTCTACAACAACCTGGAGAACTTCAACGTGGACAAGGAAGCAGGGGAG
AGGCAGATCTACCACCGATACTGCATGGAAAGGGCGGCAGCCCACTGCGCTCACGTCTTCACTACTGTGTCCCAGATCACCGCCATCGAG
GCACAGCACTTGCTCAAGAGGAAACCAGGGATCTGGTCTGAGGGGGCGGACGGCACTGATATCAACGCTGTGGCCCGCTCTCATGATGGG
AAGTTGCTGGCTTCAGCTGATGACTTTGGCAAAGTTCACCTGTTTAGCTACCCCTGCTGTCAGCCTCGAGTTCTGGGAAAGTGGCCCAGC
GCTGCGGAAGCGGCCCTTTCATCGGGCATCCGGGTGCTCTTTCGACCCCTCGTGGCCAGTCTTGGACCTGCATGGAAAAATGTGCCAAGA
AAGTTCTGCTGGAAAAGTGCTGGTGATTCTCCACGTGACCCTCCTCCGCGCCCCCAGGGTCACTCTCAGCCTTCCTTCCCCAGCTCGGGG
CCCTGGGAGACCGCCGTGTGCAAATTCTATCGGCAGGGTCGGTGGAGAGAGGTCAGGGTATTTGCTTCCTGGGCCCCTCCCTGCATCCCG
CACTCACAGTGGCTGTGGTTCCCCTCCTCTGAGCCGCAGTTCCTCTGGGAACTCGAGCTGTCCCTGGAGACGGGTAACAGACTCCCTCCC
TGTCCCTTCTGCCCTAGGCTGGCGATGGCTTCGTGCCCACTTCGGATGGTCCCCTGGGGCCGCCCCATCCTTTGTGGCTTTCTCCACTCT

>35427_35427_12_GYS1-EML2_GYS1_chr19_49488717_ENST00000541188_EML2_chr19_46116929_ENST00000589876_length(amino acids)=403AA_BP=194
MNSTWRTQCSSKWPGRWLTRVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSE
EKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQ
ITAIEAQHLLKRKPGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRVLGKWPSAAEAALSSGIRVLFRPLVASLGPAW
KNVPRKFCWKSAGDSPRDPPPRPQGHSQPSFPSSGPWETAVCKFYRQGRWREVRVFASWAPPCIPHSQWLWFPSSEPQFLWELELSLETG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GYS1-EML2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GYS1-EML2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GYS1-EML2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source