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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GYS1-HOMER3 (FusionGDB2 ID:35430)

Fusion Gene Summary for GYS1-HOMER3

check button Fusion gene summary
Fusion gene informationFusion gene name: GYS1-HOMER3
Fusion gene ID: 35430
HgeneTgene
Gene symbol

GYS1

HOMER3

Gene ID

2997

9454

Gene nameglycogen synthase 1homer scaffold protein 3
SynonymsGSY|GYSHOMER-3|VESL3
Cytomap

19q13.33

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionglycogen [starch] synthase, muscleglycogen synthase 1 (muscle)homer protein homolog 3Homer, neuronal immediate early gene, 3homer homolog 3homer scaffolding protein 3
Modification date2020031320200327
UniProtAcc

P13807

.
Ensembl transtripts involved in fusion geneENST00000263276, ENST00000323798, 
ENST00000457974, ENST00000540532, 
ENST00000541188, ENST00000544287, 
ENST00000355887, ENST00000542541, 
ENST00000594439, ENST00000594794, 
ENST00000221222, ENST00000392351, 
ENST00000433218, ENST00000539827, 
Fusion gene scores* DoF score9 X 10 X 7=6303 X 3 X 3=27
# samples 103
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GYS1 [Title/Abstract] AND HOMER3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGYS1(49494559)-HOMER3(19045219), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGYS1

GO:0005978

glycogen biosynthetic process

16275910


check buttonFusion gene breakpoints across GYS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HOMER3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1699-01AGYS1chr19

49494559

-HOMER3chr19

19045219

-


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Fusion Gene ORF analysis for GYS1-HOMER3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263276ENST00000355887GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000263276ENST00000542541GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000263276ENST00000594439GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000263276ENST00000594794GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000323798ENST00000355887GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000323798ENST00000542541GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000323798ENST00000594439GYS1chr19

49494559

-HOMER3chr19

19045219

-
5CDS-intronENST00000323798ENST00000594794GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-3CDSENST00000457974ENST00000221222GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-3CDSENST00000457974ENST00000392351GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-3CDSENST00000457974ENST00000433218GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-3CDSENST00000457974ENST00000539827GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-intronENST00000457974ENST00000355887GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-intronENST00000457974ENST00000542541GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-intronENST00000457974ENST00000594439GYS1chr19

49494559

-HOMER3chr19

19045219

-
5UTR-intronENST00000457974ENST00000594794GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000263276ENST00000221222GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000263276ENST00000392351GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000263276ENST00000433218GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000263276ENST00000539827GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000323798ENST00000221222GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000323798ENST00000392351GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000323798ENST00000433218GYS1chr19

49494559

-HOMER3chr19

19045219

-
In-frameENST00000323798ENST00000539827GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000540532ENST00000221222GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000540532ENST00000392351GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000540532ENST00000433218GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000540532ENST00000539827GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000541188ENST00000221222GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000541188ENST00000392351GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000541188ENST00000433218GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000541188ENST00000539827GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000544287ENST00000221222GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000544287ENST00000392351GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000544287ENST00000433218GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-3CDSENST00000544287ENST00000539827GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000540532ENST00000355887GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000540532ENST00000542541GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000540532ENST00000594439GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000540532ENST00000594794GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000541188ENST00000355887GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000541188ENST00000542541GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000541188ENST00000594439GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000541188ENST00000594794GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000544287ENST00000355887GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000544287ENST00000542541GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000544287ENST00000594439GYS1chr19

49494559

-HOMER3chr19

19045219

-
intron-intronENST00000544287ENST00000594794GYS1chr19

49494559

-HOMER3chr19

19045219

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323798GYS1chr1949494559-ENST00000433218HOMER3chr1919045219-1513497201270416
ENST00000323798GYS1chr1949494559-ENST00000221222HOMER3chr1919045219-1511497201270416
ENST00000323798GYS1chr1949494559-ENST00000539827HOMER3chr1919045219-1520497201279419
ENST00000323798GYS1chr1949494559-ENST00000392351HOMER3chr1919045219-1520497201279419
ENST00000263276GYS1chr1949494559-ENST00000433218HOMER3chr1919045219-1514498211271416
ENST00000263276GYS1chr1949494559-ENST00000221222HOMER3chr1919045219-1512498211271416
ENST00000263276GYS1chr1949494559-ENST00000539827HOMER3chr1919045219-1521498211280419
ENST00000263276GYS1chr1949494559-ENST00000392351HOMER3chr1919045219-1521498211280419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323798ENST00000433218GYS1chr1949494559-HOMER3chr1919045219-0.0067530040.99324703
ENST00000323798ENST00000221222GYS1chr1949494559-HOMER3chr1919045219-0.0067667610.99323326
ENST00000323798ENST00000539827GYS1chr1949494559-HOMER3chr1919045219-0.0066129490.99338704
ENST00000323798ENST00000392351GYS1chr1949494559-HOMER3chr1919045219-0.0066129490.99338704
ENST00000263276ENST00000433218GYS1chr1949494559-HOMER3chr1919045219-0.0067859170.99321413
ENST00000263276ENST00000221222GYS1chr1949494559-HOMER3chr1919045219-0.0068013220.9931987
ENST00000263276ENST00000539827GYS1chr1949494559-HOMER3chr1919045219-0.006622980.99337703
ENST00000263276ENST00000392351GYS1chr1949494559-HOMER3chr1919045219-0.006622980.99337703

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Fusion Genomic Features for GYS1-HOMER3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GYS1-HOMER3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49494559/chr19:19045219)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GYS1

P13807

.
FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOMER3chr19:49494559chr19:19045219ENST0000022122229191_243101359.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST0000022122229254_358101359.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000355887310191_243101359.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000355887310254_358101359.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000392351310191_243101362.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000392351310254_358101362.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000433218310191_243101359.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000433218310254_358101359.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST0000053982729191_243101362.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST0000053982729254_358101362.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000542541310191_243101362.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST00000542541310254_358101362.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST0000059443908191_2430326.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST0000059443908254_3580326.0Coiled coilOntology_term=ECO:0000255
TgeneHOMER3chr19:49494559chr19:19045219ENST0000022122229206_211101359.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST00000355887310206_211101359.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST00000392351310206_211101362.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST00000433218310206_211101359.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST0000053982729206_211101362.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST00000542541310206_211101362.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST0000059443908206_2110326.0Compositional biasNote=Poly-Ala
TgeneHOMER3chr19:49494559chr19:19045219ENST00000594439081_1130326.0DomainWH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOMER3chr19:49494559chr19:19045219ENST00000221222291_113101359.0DomainWH1
TgeneHOMER3chr19:49494559chr19:19045219ENST000003558873101_113101359.0DomainWH1
TgeneHOMER3chr19:49494559chr19:19045219ENST000003923513101_113101362.0DomainWH1
TgeneHOMER3chr19:49494559chr19:19045219ENST000004332183101_113101359.0DomainWH1
TgeneHOMER3chr19:49494559chr19:19045219ENST00000539827291_113101362.0DomainWH1
TgeneHOMER3chr19:49494559chr19:19045219ENST000005425413101_113101362.0DomainWH1


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Fusion Gene Sequence for GYS1-HOMER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35430_35430_1_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000221222_length(transcript)=1512nt_BP=498nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTG
GCCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGT
GCCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTG
TCTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAG
GCCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAG
GCTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAA
ACCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAG
AAGGTGCAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGGGAGCGGGCG
CGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCCTGGCTGAG
GCTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGGCCCATTCGT
CCTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCTGGTTGTTGG

>35430_35430_1_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000221222_length(amino acids)=416AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNA

--------------------------------------------------------------
>35430_35430_2_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000392351_length(transcript)=1521nt_BP=498nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTG
GCCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGT
GCCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTG
TCTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAG
GCCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAG
GCTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAA
ACCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAG
AAGGTGCAGGACCTGGAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGG
GAGCGGGCGCGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGC
CTGGCTGAGGCTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGG
CCCATTCGTCCTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCT

>35430_35430_2_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000392351_length(amino acids)=419AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLET

--------------------------------------------------------------
>35430_35430_3_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000433218_length(transcript)=1514nt_BP=498nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTG
GCCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGT
GCCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTG
TCTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAG
GCCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAG
GCTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAA
ACCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAG
AAGGTGCAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGGGAGCGGGCG
CGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCCTGGCTGAG
GCTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGGCCCATTCGT
CCTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCTGGTTGTTGG

>35430_35430_3_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000433218_length(amino acids)=416AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNA

--------------------------------------------------------------
>35430_35430_4_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000539827_length(transcript)=1521nt_BP=498nt
CAGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCT
TCCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCC
CCCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTG
GAGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACA
GGGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACC
CCGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTG
GCCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGT
GCCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTG
TCTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAG
GCCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAG
GCTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAA
ACCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAG
AAGGTGCAGGACCTGGAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGG
GAGCGGGCGCGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGC
CTGGCTGAGGCTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGG
CCCATTCGTCCTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCT

>35430_35430_4_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000263276_HOMER3_chr19_19045219_ENST00000539827_length(amino acids)=419AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLET

--------------------------------------------------------------
>35430_35430_5_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000221222_length(transcript)=1511nt_BP=497nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTGG
CCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGTG
CCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTGT
CTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAGG
CCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAGG
CTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAAA
CCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAGA
AGGTGCAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGGGAGCGGGCGC
GGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCCTGGCTGAGG
CTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGGCCCATTCGTC
CTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCTGGTTGTTGGC

>35430_35430_5_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000221222_length(amino acids)=416AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNA

--------------------------------------------------------------
>35430_35430_6_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000392351_length(transcript)=1520nt_BP=497nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTGG
CCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGTG
CCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTGT
CTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAGG
CCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAGG
CTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAAA
CCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAGA
AGGTGCAGGACCTGGAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGGG
AGCGGGCGCGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCC
TGGCTGAGGCTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGGC
CCATTCGTCCTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCTG

>35430_35430_6_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000392351_length(amino acids)=419AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLET

--------------------------------------------------------------
>35430_35430_7_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000433218_length(transcript)=1513nt_BP=497nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTGG
CCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGTG
CCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTGT
CTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAGG
CCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAGG
CTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAAA
CCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAGA
AGGTGCAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGGGAGCGGGCGC
GGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCCTGGCTGAGG
CTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGGCCCATTCGTC
CTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCTGGTTGTTGGC

>35430_35430_7_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000433218_length(amino acids)=416AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNA

--------------------------------------------------------------
>35430_35430_8_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000539827_length(transcript)=1520nt_BP=497nt
AGTGACGCTGCGGCCTCCTTCTGCCTAGGTCCCAACGCTTCGGGGCAGGGGTGCGGTCTTGCAATAGGAAGCCGAGCGTCTTGCAAGCTT
CCCGTCGGGCACCAGCTACTCGGCCCCGCACCCTACCTGGTGCATTCCCTAGACACCTCCGGGGTCCCTACCTGGAGATCCCCGGAGCCC
CCCTTCCTGCGCCAGCCATGCCTTTAAACCGCACTTTGTCCATGTCCTCACTGCCAGGACTGGAGGACTGGGAGGATGAATTCGACCTGG
AGAACGCAGTGCTCTTCGAAGTGGCCTGGGAGGTGGCTAACAAGGTGGGTGGCATCTACACGGTGCTGCAGACGAAGGCGAAGGTGACAG
GGGACGAATGGGGCGACAACTACTTCCTGGTGGGGCCGTACACGGAGCAGGGCGTGAGGACCCAGGTGGAACTGCTGGAGGCCCCCACCC
CGGCCCTGAAGAGGACACTGGATTCCATGAACAGCAAGGGCTGCAAGTTTGCCGAGAAGTTCCAGGAAGTGAAGGAAGCAGCCAGGCTGG
CCAGGGAGAAATCTCAGGATGGCGGGGAGCTCACCAGTCCAGCCCTGGGGCTCGCCTCCCACCAGGTGCCCCCGAGCCCTCTCGTCAGTG
CCAACGGCCCCGGCGAGGAAAAACTGTTCCGCAGCCAGAGCGCTGATGCCCCCGGCCCCACAGAGCGCGAGCGGCTAAAGAAGATGTTGT
CTGAGGGCTCCGTGGGCGAGGTACAGTGGGAGGCCGAGTTTTTCGCACTGCAGGACAGCAACAACAAGCTGGCAGGCGCCCTGCGAGAGG
CCAACGCCGCCGCAGCCCAGTGGAGGCAGCAGCTGGAGGCTCAGCGTGCAGAGGCCGAGCGGCTGCGGCAGCGGGTGGCTGAGCTGGAGG
CTCAGGCAGCTTCAGAGGTGACCCCCACCGGTGAGAAGGAGGGGCTGGGCCAGGGCCAGTCGCTGGAACAGCTGGAAGCTCTGGTGCAAA
CCAAGGACCAGGAGATTCAGACCCTGAAGAGTCAGACTGGGGGGCCCCGCGAGGCCCTGGAGGCTGCCGAGCGTGAGGAGACTCAGCAGA
AGGTGCAGGACCTGGAGACCCGCAATGCGGAGTTGGAGCACCAGCTGCGGGCGATGGAGCGCAGCCTGGAGGAGGCACGGGCAGAGCGGG
AGCGGGCGCGGGCTGAGGTGGGCCGGGCAGCGCAGCTGCTGGACGTCAGCCTGTTTGAGCTGAGTGAGCTGCGTGAGGGCCTGGCCCGCC
TGGCTGAGGCTGCGCCCTGAGCCGGGGCTGGTTTTCTATGAACGATTCCGGCCTGGGATGCGGGCCAGGCTGCAGGCGGCATAGTTGGGC
CCATTCGTCCTGGAAAGGGACTGGGGGGTCCCAACTTAGCCCTGGGTGGGCCGGGCCGGGCTGGGCTGGGGTGGGCCCCAGTCGGCTCTG

>35430_35430_8_GYS1-HOMER3_GYS1_chr19_49494559_ENST00000323798_HOMER3_chr19_19045219_ENST00000539827_length(amino acids)=419AA_BP=159
MPRSQRFGAGVRSCNRKPSVLQASRRAPATRPRTLPGAFPRHLRGPYLEIPGAPLPAPAMPLNRTLSMSSLPGLEDWEDEFDLENAVLFE
VAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKFAEKFQEVKEAARLAREKSQD
GGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ
WRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GYS1-HOMER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GYS1-HOMER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GYS1-HOMER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource