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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HADH-HPGD (FusionGDB2 ID:35582)

Fusion Gene Summary for HADH-HPGD

check button Fusion gene summary
Fusion gene informationFusion gene name: HADH-HPGD
Fusion gene ID: 35582
HgeneTgene
Gene symbol

HADH

HPGD

Gene ID

3033

3248

Gene namehydroxyacyl-CoA dehydrogenase15-hydroxyprostaglandin dehydrogenase
SynonymsHAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHAD15-PGDH|PGDH|PGDH1|PHOAR1|SDR36C1
Cytomap

4q25

4q34.1

Type of geneprotein-codingprotein-coding
Descriptionhydroxyacyl-coenzyme A dehydrogenase, mitochondrialL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainmedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseshort-chain 3-hydroxyacyl-CoA dehydrogenasetestis secretory sperm-binding protein Li15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas
Modification date2020032020200313
UniProtAcc

Q16836

O60760

Ensembl transtripts involved in fusion geneENST00000309522, ENST00000403312, 
ENST00000603302, ENST00000505878, 
ENST00000454409, ENST00000510728, 
ENST00000504433, ENST00000510901, 
ENST00000541923, ENST00000542498, 
ENST00000422112, ENST00000296521, 
ENST00000296522, 
Fusion gene scores* DoF score7 X 6 X 3=1262 X 2 X 2=8
# samples 72
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: HADH [Title/Abstract] AND HPGD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHADH(108911220)-HPGD(175429943), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHPGD

GO:0006693

prostaglandin metabolic process

16828555|21072165

TgeneHPGD

GO:0007179

transforming growth factor beta receptor signaling pathway

15574495

TgeneHPGD

GO:0007565

female pregnancy

15531523

TgeneHPGD

GO:0007567

parturition

15531523

TgeneHPGD

GO:0045786

negative regulation of cell cycle

15574495


check buttonFusion gene breakpoints across HADH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HPGD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3NF-01AHADHchr4

108911220

-HPGDchr4

175429943

-
ChimerDB4UCECTCGA-AJ-A3NF-01AHADHchr4

108911220

+HPGDchr4

175429943

-
ChimerDB4UCECTCGA-AJ-A3NFHADHchr4

108911220

+HPGDchr4

175429943

-


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Fusion Gene ORF analysis for HADH-HPGD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309522ENST00000504433HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000309522ENST00000510901HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000309522ENST00000541923HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000309522ENST00000542498HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000403312ENST00000504433HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000403312ENST00000510901HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000403312ENST00000541923HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000403312ENST00000542498HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000603302ENST00000504433HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000603302ENST00000510901HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000603302ENST00000541923HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-5UTRENST00000603302ENST00000542498HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-intronENST00000309522ENST00000422112HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-intronENST00000403312ENST00000422112HADHchr4

108911220

+HPGDchr4

175429943

-
5CDS-intronENST00000603302ENST00000422112HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-3CDSENST00000505878ENST00000296521HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-3CDSENST00000505878ENST00000296522HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-5UTRENST00000505878ENST00000504433HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-5UTRENST00000505878ENST00000510901HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-5UTRENST00000505878ENST00000541923HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-5UTRENST00000505878ENST00000542498HADHchr4

108911220

+HPGDchr4

175429943

-
5UTR-intronENST00000505878ENST00000422112HADHchr4

108911220

+HPGDchr4

175429943

-
In-frameENST00000309522ENST00000296521HADHchr4

108911220

+HPGDchr4

175429943

-
In-frameENST00000309522ENST00000296522HADHchr4

108911220

+HPGDchr4

175429943

-
In-frameENST00000403312ENST00000296521HADHchr4

108911220

+HPGDchr4

175429943

-
In-frameENST00000403312ENST00000296522HADHchr4

108911220

+HPGDchr4

175429943

-
In-frameENST00000603302ENST00000296521HADHchr4

108911220

+HPGDchr4

175429943

-
In-frameENST00000603302ENST00000296522HADHchr4

108911220

+HPGDchr4

175429943

-
intron-3CDSENST00000454409ENST00000296521HADHchr4

108911220

+HPGDchr4

175429943

-
intron-3CDSENST00000454409ENST00000296522HADHchr4

108911220

+HPGDchr4

175429943

-
intron-3CDSENST00000510728ENST00000296521HADHchr4

108911220

+HPGDchr4

175429943

-
intron-3CDSENST00000510728ENST00000296522HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000454409ENST00000504433HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000454409ENST00000510901HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000454409ENST00000541923HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000454409ENST00000542498HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000510728ENST00000504433HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000510728ENST00000510901HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000510728ENST00000541923HADHchr4

108911220

+HPGDchr4

175429943

-
intron-5UTRENST00000510728ENST00000542498HADHchr4

108911220

+HPGDchr4

175429943

-
intron-intronENST00000454409ENST00000422112HADHchr4

108911220

+HPGDchr4

175429943

-
intron-intronENST00000510728ENST00000422112HADHchr4

108911220

+HPGDchr4

175429943

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000603302HADHchr4108911220+ENST00000296522HPGDchr4175429943-260735142827261
ENST00000603302HADHchr4108911220+ENST00000296521HPGDchr4175429943-116235142563173
ENST00000403312HADHchr4108911220+ENST00000296522HPGDchr4175429943-260735142827261
ENST00000403312HADHchr4108911220+ENST00000296521HPGDchr4175429943-116235142563173
ENST00000309522HADHchr4108911220+ENST00000296522HPGDchr4175429943-253728141757238
ENST00000309522HADHchr4108911220+ENST00000296521HPGDchr4175429943-109228141493150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000603302ENST00000296522HADHchr4108911220+HPGDchr4175429943-0.0007067390.9992932
ENST00000603302ENST00000296521HADHchr4108911220+HPGDchr4175429943-0.0403151920.95968485
ENST00000403312ENST00000296522HADHchr4108911220+HPGDchr4175429943-0.0007067390.9992932
ENST00000403312ENST00000296521HADHchr4108911220+HPGDchr4175429943-0.0403151920.95968485
ENST00000309522ENST00000296522HADHchr4108911220+HPGDchr4175429943-0.0003450290.999655
ENST00000309522ENST00000296521HADHchr4108911220+HPGDchr4175429943-0.0065067510.99349326

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Fusion Genomic Features for HADH-HPGD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HADH-HPGD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:108911220/chr4:175429943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HADH

Q16836

HPGD

O60760

FUNCTION: Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}.FUNCTION: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHADHchr4:108911220chr4:175429943ENST00000309522+1834_3944315.0Nucleotide bindingNAD
HgeneHADHchr4:108911220chr4:175429943ENST00000603302+1934_3944332.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST0000029652126151_155108179.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST0000029652227151_155108267.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000004221120512_200199.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST0000042211205151_1550199.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000004221120536_370199.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000004221120563_650199.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005109012712_200146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST0000051090127151_1550146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005109012736_370146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005109012763_650146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005419231612_200146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST0000054192316151_1550146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005419231636_370146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005419231663_650146.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST0000054249825151_155108144.0Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHPGDchr4:108911220chr4:175429943ENST000002965212612_20108179.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000002965212636_37108179.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000002965212663_65108179.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000002965222712_20108267.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000002965222736_37108267.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000002965222763_65108267.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005424982512_20108144.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005424982536_37108144.0Nucleotide bindingNAD
TgeneHPGDchr4:108911220chr4:175429943ENST000005424982563_65108144.0Nucleotide bindingNAD


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Fusion Gene Sequence for HADH-HPGD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35582_35582_1_HADH-HPGD_HADH_chr4_108911220_ENST00000309522_HPGD_chr4_175429943_ENST00000296521_length(transcript)=1092nt_BP=281nt
CCCCGCCTTGTGGCGTCACGGGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCT
GCCCGCCTCGCGCGTCTTCCCTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTT
CCGTGTCCTCCTCGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCG
GCATTGCCCAGGTTTCTGTTATCAGTGGAACCTATCTTGGTTTGGATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCA
ATATGTCATCTTTAGCAGGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAG
CAGCGCCCACCATTGATTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAG
GGAATTCATTTTCAAGACTATGATACAACTCCATTTCAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCAC
AAATAGCTTATATTCAGATCCTATCTTCATTTGAATATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGA
TAAACGTTTTCTAAATTTTTAGTTAAGTATATGGATAAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATC
TTGATAGTCTAAAAAATGATCAAAACAAATGATTTTCAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGTGCTTCA
TAAATATTAATGTTCTTCAGAACATCATTTTAAAGGAGATACTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAG
TTCATACTTTAAAAGAGGAAAGCTACTTAACAATGACAAATATTTCACAATAATAATTTTTACTTATATACCATCTTTCAACTGAACATT

>35582_35582_1_HADH-HPGD_HADH_chr4_108911220_ENST00000309522_HPGD_chr4_175429943_ENST00000296521_length(amino acids)=150AA_BP=80
MQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVSVISGTYLG

--------------------------------------------------------------
>35582_35582_2_HADH-HPGD_HADH_chr4_108911220_ENST00000309522_HPGD_chr4_175429943_ENST00000296522_length(transcript)=2537nt_BP=281nt
CCCCGCCTTGTGGCGTCACGGGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCT
GCCCGCCTCGCGCGTCTTCCCTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTT
CCGTGTCCTCCTCGTCCACCGCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCG
GCATTGCCCAGGTTTCTGTTATCAGTGGAACCTATCTTGGTTTGGATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCA
ATATGTCATCTTTAGCAGGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAG
CAGCGTTGGCTGCTAATCTTATGAACAGTGGTGTGAGACTGAATGCCATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTG
AAAAAGAAGAAAACATGGGACAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTGGACCCACCATTGA
TTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAG
ACTATGATACAACTCCATTTCAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCTTATATTCA
GATCCTATCTTCATTTGAATATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGATAAACGTTTTCTAAAT
TTTTAGTTAAGTATATGGATAAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATCTTGATAGTCTAAAAAA
TGATCAAAACAAATGATTTTCAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGTGCTTCATAAATATTAATGTTCT
TCAGAACATCATTTTAAAGGAGATACTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGA
GGAAAGCTACTTAACAATGACAAATATTTCACAATAATAATTTTTACTTATATACCATCTTTCAACTGAACATTTCAGTTCTTCCAAGAG
CTTCTTAGAGTAGTATATTTTGGGGGCAGTCAAGGAATAAACTACAGTGTAAACATATCCCAGATGAAAACTGCTGTATGGAAAAATGAC
AGAAAGTAACTGATTGACACTGTTGATTCACAGTTCAGCCTCCTATCTGGGAAAGACATTTCTTTCCTCTGCTCACTTTAAGAACTTTTA
CCGACTCCAAAAATCTCAGGAATTAAACTTTTAACAGTTACAGCAATAAAGAATAGTTAGTACTCCAAAAATATTATATTTAAGATGCTC
AACAAGAAAAAAATGCAAATGTAATATTTTTTTCAAATTACTTCTTTATTGACTTGTCCAAATTTCAAAAGTGCCTACCCTTCAATAAAA
CTTTTTTATTCTGATCTCCATAAATTACTTAGTCTTCTATGTATAGCTATCAAGGAAATAAAACCAATTTTGCCACAGCCACAACTGTAA
ATGTTTTTGTACCCATGCTGAAACTCATAACAACACAGACATAAAAATAGCTGTGAGGTTTTGCTTTTTTTGTTGTCAGCTATCTTAAGA
ATCATTAAATACACCTGCTTTGGGTAAAACTCTTTGCAAGCAGTAATTAACACTAGTAACAGTGAAAGCACAAGATTTCCAAATCAGTCG
TTTTCTCAAAAAAATATCGTATAAGTGACTCATCCTGTCTGCTAACTCCAGACCTCCCAGCTTGAAGCCAAATCTTTCCATGTGAGATTG
ATATGGATTTCCTAGAAGTACTGGAATGTTGTCATATCTTGCCCTATTTTAATTCTGCTATAGAAAACAATTGCCTTCACTTTTAAGGAG
TAATTTGAATATTAATAACTCTGGTCTAGATTTTCATATAATGTATTAAAGACAAAGTAGTGAACATCAATGAACATCTGATAGAGATAA
ACTGTAATCAGGCATAAGCTTGTTTGTATGTTCTGGCAGTGACTAATCAGTAAATGATGTCGGTTTGCCCAGTATCACTTATCTTCTGTA
TTTTTCCTCTGTCGTGTAAATAGTATAACCTTTTCATTTATGGACAATTTTTTGGACTAGTAGCCTTCAATATACATTCTGCTTTGAATT
AATTTTTTCAAATCAATAAATTATGTAGACATTTAAAATCAAATATCAAGTAGAATTGAAAAATGTGAGTTACATAAGTTAAAAACTTAC
TTTAAATCTTACCTTCTATAGGTAGCTCTAAATAAATTCATATGGTTATATGGCATCTCTGGTGTATACTGATTGAGAAAATAATTAAAC

>35582_35582_2_HADH-HPGD_HADH_chr4_108911220_ENST00000309522_HPGD_chr4_175429943_ENST00000296522_length(amino acids)=238AA_BP=80
MQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVSVISGTYLG
LDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKD

--------------------------------------------------------------
>35582_35582_3_HADH-HPGD_HADH_chr4_108911220_ENST00000403312_HPGD_chr4_175429943_ENST00000296521_length(transcript)=1162nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGGTTTCTGTT
ATCAGTGGAACCTATCTTGGTTTGGATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCAGGA
CTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAGCAGCGCCCACCATTGATTGC
CAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTA
TGATACAACTCCATTTCAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCTTATATTCAGATC
CTATCTTCATTTGAATATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGATAAACGTTTTCTAAATTTTT
AGTTAAGTATATGGATAAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATCTTGATAGTCTAAAAAATGAT
CAAAACAAATGATTTTCAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGTGCTTCATAAATATTAATGTTCTTCAG
AACATCATTTTAAAGGAGATACTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGAGGAA

>35582_35582_3_HADH-HPGD_HADH_chr4_108911220_ENST00000403312_HPGD_chr4_175429943_ENST00000296521_length(amino acids)=173AA_BP=103
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT

--------------------------------------------------------------
>35582_35582_4_HADH-HPGD_HADH_chr4_108911220_ENST00000403312_HPGD_chr4_175429943_ENST00000296522_length(transcript)=2607nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGGTTTCTGTT
ATCAGTGGAACCTATCTTGGTTTGGATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCAGGA
CTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAGCAGCGTTGGCTGCTAATCTT
ATGAACAGTGGTGTGAGACTGAATGCCATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAAAACATGGGA
CAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTGGACCCACCATTGATTGCCAATGGATTGATAACA
CTCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCATTT
CAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCTTATATTCAGATCCTATCTTCATTTGAAT
ATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGATAAACGTTTTCTAAATTTTTAGTTAAGTATATGGAT
AAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATCTTGATAGTCTAAAAAATGATCAAAACAAATGATTTT
CAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGTGCTTCATAAATATTAATGTTCTTCAGAACATCATTTTAAAGG
AGATACTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGAGGAAAGCTACTTAACAATGA
CAAATATTTCACAATAATAATTTTTACTTATATACCATCTTTCAACTGAACATTTCAGTTCTTCCAAGAGCTTCTTAGAGTAGTATATTT
TGGGGGCAGTCAAGGAATAAACTACAGTGTAAACATATCCCAGATGAAAACTGCTGTATGGAAAAATGACAGAAAGTAACTGATTGACAC
TGTTGATTCACAGTTCAGCCTCCTATCTGGGAAAGACATTTCTTTCCTCTGCTCACTTTAAGAACTTTTACCGACTCCAAAAATCTCAGG
AATTAAACTTTTAACAGTTACAGCAATAAAGAATAGTTAGTACTCCAAAAATATTATATTTAAGATGCTCAACAAGAAAAAAATGCAAAT
GTAATATTTTTTTCAAATTACTTCTTTATTGACTTGTCCAAATTTCAAAAGTGCCTACCCTTCAATAAAACTTTTTTATTCTGATCTCCA
TAAATTACTTAGTCTTCTATGTATAGCTATCAAGGAAATAAAACCAATTTTGCCACAGCCACAACTGTAAATGTTTTTGTACCCATGCTG
AAACTCATAACAACACAGACATAAAAATAGCTGTGAGGTTTTGCTTTTTTTGTTGTCAGCTATCTTAAGAATCATTAAATACACCTGCTT
TGGGTAAAACTCTTTGCAAGCAGTAATTAACACTAGTAACAGTGAAAGCACAAGATTTCCAAATCAGTCGTTTTCTCAAAAAAATATCGT
ATAAGTGACTCATCCTGTCTGCTAACTCCAGACCTCCCAGCTTGAAGCCAAATCTTTCCATGTGAGATTGATATGGATTTCCTAGAAGTA
CTGGAATGTTGTCATATCTTGCCCTATTTTAATTCTGCTATAGAAAACAATTGCCTTCACTTTTAAGGAGTAATTTGAATATTAATAACT
CTGGTCTAGATTTTCATATAATGTATTAAAGACAAAGTAGTGAACATCAATGAACATCTGATAGAGATAAACTGTAATCAGGCATAAGCT
TGTTTGTATGTTCTGGCAGTGACTAATCAGTAAATGATGTCGGTTTGCCCAGTATCACTTATCTTCTGTATTTTTCCTCTGTCGTGTAAA
TAGTATAACCTTTTCATTTATGGACAATTTTTTGGACTAGTAGCCTTCAATATACATTCTGCTTTGAATTAATTTTTTCAAATCAATAAA
TTATGTAGACATTTAAAATCAAATATCAAGTAGAATTGAAAAATGTGAGTTACATAAGTTAAAAACTTACTTTAAATCTTACCTTCTATA

>35582_35582_4_HADH-HPGD_HADH_chr4_108911220_ENST00000403312_HPGD_chr4_175429943_ENST00000296522_length(amino acids)=261AA_BP=103
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGF

--------------------------------------------------------------
>35582_35582_5_HADH-HPGD_HADH_chr4_108911220_ENST00000603302_HPGD_chr4_175429943_ENST00000296521_length(transcript)=1162nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGGTTTCTGTT
ATCAGTGGAACCTATCTTGGTTTGGATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCAGGA
CTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAGCAGCGCCCACCATTGATTGC
CAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTA
TGATACAACTCCATTTCAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCTTATATTCAGATC
CTATCTTCATTTGAATATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGATAAACGTTTTCTAAATTTTT
AGTTAAGTATATGGATAAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATCTTGATAGTCTAAAAAATGAT
CAAAACAAATGATTTTCAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGTGCTTCATAAATATTAATGTTCTTCAG
AACATCATTTTAAAGGAGATACTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGAGGAA

>35582_35582_5_HADH-HPGD_HADH_chr4_108911220_ENST00000603302_HPGD_chr4_175429943_ENST00000296521_length(amino acids)=173AA_BP=103
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT

--------------------------------------------------------------
>35582_35582_6_HADH-HPGD_HADH_chr4_108911220_ENST00000603302_HPGD_chr4_175429943_ENST00000296522_length(transcript)=2607nt_BP=351nt
CGTGTATACCCGCTCAACGCTGGGACGTTACAGCCAGGGCCAATGGGCAGAGCGGGACTCGAGGCCCCGCCCCCGCCTTGTGGCGTCACG
GGGACGCCGGGGGCGCGCGGGCTGCAGGGCCGCGTAGGTCCCCGCCCCCAGAGTCTGGCTTTCCGCGGCTGCCCGCCTCGCGCGTCTTCC
CTGCCCGGGTCTCCTCGCTGTCGCCGCCGCTGCCACACCATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACC
GCCTCGGCCTCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCCGGCATTGCCCAGGTTTCTGTT
ATCAGTGGAACCTATCTTGGTTTGGATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCAGGA
CTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAGCAGCGTTGGCTGCTAATCTT
ATGAACAGTGGTGTGAGACTGAATGCCATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAAAACATGGGA
CAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTGGACCCACCATTGATTGCCAATGGATTGATAACA
CTCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCATTT
CAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCTTATATTCAGATCCTATCTTCATTTGAAT
ATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGATAAACGTTTTCTAAATTTTTAGTTAAGTATATGGAT
AAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATCTTGATAGTCTAAAAAATGATCAAAACAAATGATTTT
CAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGTGCTTCATAAATATTAATGTTCTTCAGAACATCATTTTAAAGG
AGATACTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGAGGAAAGCTACTTAACAATGA
CAAATATTTCACAATAATAATTTTTACTTATATACCATCTTTCAACTGAACATTTCAGTTCTTCCAAGAGCTTCTTAGAGTAGTATATTT
TGGGGGCAGTCAAGGAATAAACTACAGTGTAAACATATCCCAGATGAAAACTGCTGTATGGAAAAATGACAGAAAGTAACTGATTGACAC
TGTTGATTCACAGTTCAGCCTCCTATCTGGGAAAGACATTTCTTTCCTCTGCTCACTTTAAGAACTTTTACCGACTCCAAAAATCTCAGG
AATTAAACTTTTAACAGTTACAGCAATAAAGAATAGTTAGTACTCCAAAAATATTATATTTAAGATGCTCAACAAGAAAAAAATGCAAAT
GTAATATTTTTTTCAAATTACTTCTTTATTGACTTGTCCAAATTTCAAAAGTGCCTACCCTTCAATAAAACTTTTTTATTCTGATCTCCA
TAAATTACTTAGTCTTCTATGTATAGCTATCAAGGAAATAAAACCAATTTTGCCACAGCCACAACTGTAAATGTTTTTGTACCCATGCTG
AAACTCATAACAACACAGACATAAAAATAGCTGTGAGGTTTTGCTTTTTTTGTTGTCAGCTATCTTAAGAATCATTAAATACACCTGCTT
TGGGTAAAACTCTTTGCAAGCAGTAATTAACACTAGTAACAGTGAAAGCACAAGATTTCCAAATCAGTCGTTTTCTCAAAAAAATATCGT
ATAAGTGACTCATCCTGTCTGCTAACTCCAGACCTCCCAGCTTGAAGCCAAATCTTTCCATGTGAGATTGATATGGATTTCCTAGAAGTA
CTGGAATGTTGTCATATCTTGCCCTATTTTAATTCTGCTATAGAAAACAATTGCCTTCACTTTTAAGGAGTAATTTGAATATTAATAACT
CTGGTCTAGATTTTCATATAATGTATTAAAGACAAAGTAGTGAACATCAATGAACATCTGATAGAGATAAACTGTAATCAGGCATAAGCT
TGTTTGTATGTTCTGGCAGTGACTAATCAGTAAATGATGTCGGTTTGCCCAGTATCACTTATCTTCTGTATTTTTCCTCTGTCGTGTAAA
TAGTATAACCTTTTCATTTATGGACAATTTTTTGGACTAGTAGCCTTCAATATACATTCTGCTTTGAATTAATTTTTTCAAATCAATAAA
TTATGTAGACATTTAAAATCAAATATCAAGTAGAATTGAAAAATGTGAGTTACATAAGTTAAAAACTTACTTTAAATCTTACCTTCTATA

>35582_35582_6_HADH-HPGD_HADH_chr4_108911220_ENST00000603302_HPGD_chr4_175429943_ENST00000296522_length(amino acids)=261AA_BP=103
MGRAGLEAPPPPCGVTGTPGARGLQGRVGPRPQSLAFRGCPPRASSLPGSPRCRRRCHTMAFVTRQFMRSVSSSSTASASAKKIIVKHVT
VIGGGLMGAGIAQVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HADH-HPGD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HADH-HPGD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HADH-HPGD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource