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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HAMP-GPI (FusionGDB2 ID:35593)

Fusion Gene Summary for HAMP-GPI

check button Fusion gene summary
Fusion gene informationFusion gene name: HAMP-GPI
Fusion gene ID: 35593
HgeneTgene
Gene symbol

HAMP

GPI

Gene ID

57817

10007

Gene namehepcidin antimicrobial peptideglucosamine-6-phosphate deaminase 1
SynonymsHEPC|HFE2B|LEAP1|PLTRGNP1|GNPDA|GNPI|GPI|HLN
Cytomap

19q13.12

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionhepcidinhepcidin preproproteinliver-expressed antimicrobial peptide 1putative liver tumor regressorglucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin
Modification date2020032920200313
UniProtAcc

P81172

Q8IV16

Ensembl transtripts involved in fusion geneENST00000222304, ENST00000598398, 
ENST00000356487, ENST00000415930, 
ENST00000586425, 
Fusion gene scores* DoF score1 X 1 X 1=119 X 17 X 10=3230
# samples 123
** MAII scorelog2(1/1*10)=3.32192809488736log2(23/3230*10)=-3.81182839863691
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HAMP [Title/Abstract] AND GPI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHAMP(35773570)-GPI(34884153), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHAMP

GO:0006879

cellular iron ion homeostasis

15514116


check buttonFusion gene breakpoints across HAMP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-AAEG-01AHAMPchr19

35773570

+GPIchr19

34884153

+


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Fusion Gene ORF analysis for HAMP-GPI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000222304ENST00000356487HAMPchr19

35773570

+GPIchr19

34884153

+
In-frameENST00000222304ENST00000415930HAMPchr19

35773570

+GPIchr19

34884153

+
In-frameENST00000222304ENST00000586425HAMPchr19

35773570

+GPIchr19

34884153

+
In-frameENST00000598398ENST00000356487HAMPchr19

35773570

+GPIchr19

34884153

+
In-frameENST00000598398ENST00000415930HAMPchr19

35773570

+GPIchr19

34884153

+
In-frameENST00000598398ENST00000586425HAMPchr19

35773570

+GPIchr19

34884153

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000598398HAMPchr1935773570+ENST00000415930GPIchr1934884153+33793862271258343
ENST00000598398HAMPchr1935773570+ENST00000356487GPIchr1934884153+15513861276230348
ENST00000598398HAMPchr1935773570+ENST00000586425GPIchr1934884153+13563861033230267
ENST00000222304HAMPchr1935773570+ENST00000415930GPIchr1934884153+33153221631194343
ENST00000222304HAMPchr1935773570+ENST00000356487GPIchr1934884153+14873221212166348
ENST00000222304HAMPchr1935773570+ENST00000586425GPIchr1934884153+1292322969166267

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000598398ENST00000415930HAMPchr1935773570+GPIchr1934884153+0.0053550450.994645
ENST00000598398ENST00000356487HAMPchr1935773570+GPIchr1934884153+0.0111130440.9888869
ENST00000598398ENST00000586425HAMPchr1935773570+GPIchr1934884153+0.0504079950.94959193
ENST00000222304ENST00000415930HAMPchr1935773570+GPIchr1934884153+0.0056068390.9943931
ENST00000222304ENST00000356487HAMPchr1935773570+GPIchr1934884153+0.0140489690.985951
ENST00000222304ENST00000586425HAMPchr1935773570+GPIchr1934884153+0.067624250.9323757

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Fusion Genomic Features for HAMP-GPI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HAMPchr1935773570+GPIchr1934884152+0.0042182050.9957818
HAMPchr1935773570+GPIchr1934884152+0.0042182050.9957818

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HAMP-GPI


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:35773570/chr19:34884153)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HAMP

P81172

GPI

Q8IV16

FUNCTION: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). {ECO:0000269|PubMed:22306005}.; FUNCTION: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). {ECO:0000269|PubMed:11034317, ECO:0000269|PubMed:11113131}.FUNCTION: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity). {ECO:0000250|UniProtKB:Q9D1N2, ECO:0000269|PubMed:17997385, ECO:0000269|PubMed:19304573, ECO:0000269|PubMed:21314738, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGPIchr19:35773570chr19:34884153ENST00000356487818159_160268559.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:35773570chr19:34884153ENST00000356487818210_215268559.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:35773570chr19:34884153ENST00000415930818159_160279570.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:35773570chr19:34884153ENST00000415930818210_215279570.0RegionGlucose-6-phosphate binding


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Fusion Gene Sequence for HAMP-GPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35593_35593_1_HAMP-GPI_HAMP_chr19_35773570_ENST00000222304_GPI_chr19_34884153_ENST00000356487_length(transcript)=1487nt_BP=322nt
AACACACCTCTGCCGGCTGAGGGTGACACAACCCTGTTCCCTGTCGCTCTGTTCCCGCTTATCTCTCCCGCCTTTTCGGCGCCACCACCT
TCTTGGAAATGAGACAGAGCAAAGGGGAGGGGGCTCAGACCACCGCCTCCCCTGGCAGGCCCCATAAAAGCGACTGTCACTCGGTCCCAG
ACACCAGAGCAAGCTCAAGACCCAGCAGTGGGACAGCCAGACAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCT
GCTCCTCCTCCTCCTCGCCAGCCTGACCAGTGGCTCTGTTTTCCCACAACAGTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGG
ACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCC
CCTGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTA
TGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGT
GGACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGAT
GATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGC
CCAGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAG
GCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTTGGT
CGCCATGTATGAGCACAAGATCTTCGTTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAGCT
GGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCA
GCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGC
CGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCC
AGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCATGT

>35593_35593_1_HAMP-GPI_HAMP_chr19_35773570_ENST00000222304_GPI_chr19_34884153_ENST00000356487_length(amino acids)=348AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

--------------------------------------------------------------
>35593_35593_2_HAMP-GPI_HAMP_chr19_35773570_ENST00000222304_GPI_chr19_34884153_ENST00000415930_length(transcript)=3315nt_BP=322nt
AACACACCTCTGCCGGCTGAGGGTGACACAACCCTGTTCCCTGTCGCTCTGTTCCCGCTTATCTCTCCCGCCTTTTCGGCGCCACCACCT
TCTTGGAAATGAGACAGAGCAAAGGGGAGGGGGCTCAGACCACCGCCTCCCCTGGCAGGCCCCATAAAAGCGACTGTCACTCGGTCCCAG
ACACCAGAGCAAGCTCAAGACCCAGCAGTGGGACAGCCAGACAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCT
GCTCCTCCTCCTCCTCGCCAGCCTGACCAGTGGCTCTGTTTTCCCACAACAGTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGG
ACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCC
CCTGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTA
TGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGT
GGACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGAT
GATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGC
CCAGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAG
GCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTTGGT
CGCCATGTATGAGCACAAGATCTTCGTTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAGCT
GGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCA
GCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGC
CGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCC
AGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCATGT
TCACGTTGTTCACATCCCATGTAGAAAAATAAAGATGCCACGGAGGAGGTTGTAGGCTCAGCCTCTGATTTTTTTTTTCCTGTGATGGTG
CTTTATGTAGCAGAGGGCAGGAGCGCTCAGCAGGACGCAGGCTGTGCCTCTGCGGACACTTAACACTAAGTGGTGAGCGGGTCTAGAGTG
GAGCAAGGTGCCCTGAGAAGACAATAGTGGGGTGGGGGCACAATCAGTCAGGACGGCAACTTGGCCTGTGTCACCAAATCCCAAGACTGT
TTTCCACTCCTCACCTCTGTGACTGCAGAAATTGGATACTCTGTTCACTCGATGGTTCTAAAAACTGCATTGAGATTATGTTTGTTTCGG
GTGAATTCCTGGACAAGACCGAGGATGACTGCCATCTCCTGGCAAGACGCTCAGGTAGTTCTTTTGCTTTAAAAGGCAGATATTGAAAAC
TGGAATTTTTTTTTTTTGAGTCTCGCTCTGTCACCCAGACTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCCTCCCGGGT
TCAAGCTATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACACGGCGCACACCACCATACCCAGCTAATTTTTGTATTTTTAGTAGT
GAAGGGGTTTTACCATGTTGGGCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCACAGTGCTGGGATTAC
AGGTATGAGCCACCACGCCCGGCCCATTTTTTTTTTTTTTTTGACAACTTTTTTTTTTTTTTGAGACAGGGTCTTGTTCCATTGCCCAGA
CTGGAGTGCAGTGGCATGATCACAGCTCACTGCAGCCAGTAATCCTCTTGCCTCAGCCTCCCAAGTAGTTGAGACTACAGGTTGTACCAC
TATGCCCTGCTAGTTTTTTCATTTTTTGTAGAGAGACGGGTCTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAAGCTGGAGTG
CAGTAGCACGGTCTCAGCTCATTGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGACTCCTGTGTAGCTGGGAGTACAGG
CACCTGCCACCATGCCCGGCTAATTTTTTATATATTTTTTTAGCAGAGACAGTGTCTCACTGTGTTAGTCAGGATGGTCTCGATCTCCTG
ACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCAAGGCGGGTCTTGCTGTGTTTC
CCAGACTAGACTGGTCTTGAATTCCAGGGCTCAAGAGATCTCCCACCTCAGCCTCCCACAGTGCTGGGATTACAGGCGTGAGCCGCCACA
CCCAGCCTATTCAAAATTTTTTTTTCTTAGAGACAGGGTCTTTGTTGCCCAGGCTGGACTGCAGTGATACAATCATAGCTGACTGAAGCC
TCAAATTCCCAGGCTAAGGTGATCTTCTCACCTCAGCCTTCCAAGTAGCTGGGTCCGCAGATGCATGCCAGTACACCCAGCTCATTTAAA
AAAAAATTTTTTTCTTTTTTGAGAGTCTTGCTTTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAAGCTCCACCTCC
CGGCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTA
GTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCATGATCCGCCTGCTTTGGCCTCCCAAAGTGCTGGGAT

>35593_35593_2_HAMP-GPI_HAMP_chr19_35773570_ENST00000222304_GPI_chr19_34884153_ENST00000415930_length(amino acids)=343AA_BP=31
MSLGPRHQSKLKTQQWDSQTDGTMALSSQIWAACLLLLLLLASLTSGSVFPQQWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQ
HFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLI
HQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPF

--------------------------------------------------------------
>35593_35593_3_HAMP-GPI_HAMP_chr19_35773570_ENST00000222304_GPI_chr19_34884153_ENST00000586425_length(transcript)=1292nt_BP=322nt
AACACACCTCTGCCGGCTGAGGGTGACACAACCCTGTTCCCTGTCGCTCTGTTCCCGCTTATCTCTCCCGCCTTTTCGGCGCCACCACCT
TCTTGGAAATGAGACAGAGCAAAGGGGAGGGGGCTCAGACCACCGCCTCCCCTGGCAGGCCCCATAAAAGCGACTGTCACTCGGTCCCAG
ACACCAGAGCAAGCTCAAGACCCAGCAGTGGGACAGCCAGACAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCT
GCTCCTCCTCCTCCTCGCCAGCCTGACCAGTGGCTCTGTTTTCCCACAACAGTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGG
ACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCC
CCTGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTA
TGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGT
GGACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGAT
GATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGC
CCAGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAG
GCTGCTGCCACATAAGAGTGGAGCTGGGAAAGCAGCTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACG
ACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGT
GACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTG
GACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCT

>35593_35593_3_HAMP-GPI_HAMP_chr19_35773570_ENST00000222304_GPI_chr19_34884153_ENST00000586425_length(amino acids)=267AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL

--------------------------------------------------------------
>35593_35593_4_HAMP-GPI_HAMP_chr19_35773570_ENST00000598398_GPI_chr19_34884153_ENST00000356487_length(transcript)=1551nt_BP=386nt
GAGCCTCCCACGTGGTGTGGATGAGGAGGCAGATGGCAGGGCCTGTGCATTTCTGTGCTTGAGTGGGCCTTGAAAGTGGTTCAGCAACCA
GGAAGAAGTGTTCATTCCTCGACAACAACATCCCCGGGCTCTGGTGACTTGGCTGACACTGGATGGCCCTGGAATGAAAAAGGCAAAGAG
GCAAAATGTGCAAGGGCCCATCTGGAACCAAGGCCCCATAAAAGCGACTGTCACTCGGTCCCAGACACCAGAGCAAGCTCAAGACCCAGC
AGTGGGACAGCCAGACAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCTGCTCCTCCTCCTCCTCGCCAGCCTGA
CCAGTGGCTCTGTTTTCCCACAACAGTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTT
TTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCCCCTGGAGAAGAACGCCCCCGTCTTGC
TGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTATGACCAGTACCTGCACCGCTTTGCTG
CGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGTGGACCACCAGACAGGCCCCATTGTGT
GGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGATGATACCCTGTGACTTCCTCATCCCGG
TCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACAGAGGCCCTGATGAGGGGAA
AATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAGGCTGCTGCCACATAAGGTCTTTGAAG
GAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTTGGTCGCCATGTATGAGCACAAGATCTTCG
TTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAGCTGGCTAAGAAAATAGAGCCTGAGCTTG
ATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAAA
CTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCGGCACTGCATGTTCCTGGACACCAC
CCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAGCCTAACCCCCAGCCCCTCCATGTC
TATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCATGTTCACGTTGTTCACATCCCATGTAGAA

>35593_35593_4_HAMP-GPI_HAMP_chr19_35773570_ENST00000598398_GPI_chr19_34884153_ENST00000356487_length(amino acids)=348AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

--------------------------------------------------------------
>35593_35593_5_HAMP-GPI_HAMP_chr19_35773570_ENST00000598398_GPI_chr19_34884153_ENST00000415930_length(transcript)=3379nt_BP=386nt
GAGCCTCCCACGTGGTGTGGATGAGGAGGCAGATGGCAGGGCCTGTGCATTTCTGTGCTTGAGTGGGCCTTGAAAGTGGTTCAGCAACCA
GGAAGAAGTGTTCATTCCTCGACAACAACATCCCCGGGCTCTGGTGACTTGGCTGACACTGGATGGCCCTGGAATGAAAAAGGCAAAGAG
GCAAAATGTGCAAGGGCCCATCTGGAACCAAGGCCCCATAAAAGCGACTGTCACTCGGTCCCAGACACCAGAGCAAGCTCAAGACCCAGC
AGTGGGACAGCCAGACAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCTGCTCCTCCTCCTCCTCGCCAGCCTGA
CCAGTGGCTCTGTTTTCCCACAACAGTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTT
TTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCCCCTGGAGAAGAACGCCCCCGTCTTGC
TGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTATGACCAGTACCTGCACCGCTTTGCTG
CGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGTGGACCACCAGACAGGCCCCATTGTGT
GGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGATGATACCCTGTGACTTCCTCATCCCGG
TCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACAGAGGCCCTGATGAGGGGAA
AATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAGGCTGCTGCCACATAAGGTCTTTGAAG
GAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTTGGTCGCCATGTATGAGCACAAGATCTTCG
TTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAGCTGGCTAAGAAAATAGAGCCTGAGCTTG
ATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAAA
CTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCGGCACTGCATGTTCCTGGACACCAC
CCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAGCCTAACCCCCAGCCCCTCCATGTC
TATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCATGTTCACGTTGTTCACATCCCATGTAGAA
AAATAAAGATGCCACGGAGGAGGTTGTAGGCTCAGCCTCTGATTTTTTTTTTCCTGTGATGGTGCTTTATGTAGCAGAGGGCAGGAGCGC
TCAGCAGGACGCAGGCTGTGCCTCTGCGGACACTTAACACTAAGTGGTGAGCGGGTCTAGAGTGGAGCAAGGTGCCCTGAGAAGACAATA
GTGGGGTGGGGGCACAATCAGTCAGGACGGCAACTTGGCCTGTGTCACCAAATCCCAAGACTGTTTTCCACTCCTCACCTCTGTGACTGC
AGAAATTGGATACTCTGTTCACTCGATGGTTCTAAAAACTGCATTGAGATTATGTTTGTTTCGGGTGAATTCCTGGACAAGACCGAGGAT
GACTGCCATCTCCTGGCAAGACGCTCAGGTAGTTCTTTTGCTTTAAAAGGCAGATATTGAAAACTGGAATTTTTTTTTTTTGAGTCTCGC
TCTGTCACCCAGACTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGCTATTCTCCTGCCTCAGCCTC
CCGAGTAGCTGGGATTACACGGCGCACACCACCATACCCAGCTAATTTTTGTATTTTTAGTAGTGAAGGGGTTTTACCATGTTGGGCAGG
CTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCACAGTGCTGGGATTACAGGTATGAGCCACCACGCCCGGCCCA
TTTTTTTTTTTTTTTTGACAACTTTTTTTTTTTTTTGAGACAGGGTCTTGTTCCATTGCCCAGACTGGAGTGCAGTGGCATGATCACAGC
TCACTGCAGCCAGTAATCCTCTTGCCTCAGCCTCCCAAGTAGTTGAGACTACAGGTTGTACCACTATGCCCTGCTAGTTTTTTCATTTTT
TGTAGAGAGACGGGTCTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAAGCTGGAGTGCAGTAGCACGGTCTCAGCTCATTGCA
AGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGACTCCTGTGTAGCTGGGAGTACAGGCACCTGCCACCATGCCCGGCTAATTT
TTTATATATTTTTTTAGCAGAGACAGTGTCTCACTGTGTTAGTCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCT
CCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCAAGGCGGGTCTTGCTGTGTTTCCCAGACTAGACTGGTCTTGAATTCCA
GGGCTCAAGAGATCTCCCACCTCAGCCTCCCACAGTGCTGGGATTACAGGCGTGAGCCGCCACACCCAGCCTATTCAAAATTTTTTTTTC
TTAGAGACAGGGTCTTTGTTGCCCAGGCTGGACTGCAGTGATACAATCATAGCTGACTGAAGCCTCAAATTCCCAGGCTAAGGTGATCTT
CTCACCTCAGCCTTCCAAGTAGCTGGGTCCGCAGATGCATGCCAGTACACCCAGCTCATTTAAAAAAAAATTTTTTTCTTTTTTGAGAGT
CTTGCTTTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAAGCTCCACCTCCCGGCTTCACGCCATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAG
CCAGGATGGTCTTGATCTCCTGACCTCATGATCCGCCTGCTTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACCGCGCCCGGC

>35593_35593_5_HAMP-GPI_HAMP_chr19_35773570_ENST00000598398_GPI_chr19_34884153_ENST00000415930_length(amino acids)=343AA_BP=31
MSLGPRHQSKLKTQQWDSQTDGTMALSSQIWAACLLLLLLLASLTSGSVFPQQWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQ
HFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLI
HQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPF

--------------------------------------------------------------
>35593_35593_6_HAMP-GPI_HAMP_chr19_35773570_ENST00000598398_GPI_chr19_34884153_ENST00000586425_length(transcript)=1356nt_BP=386nt
GAGCCTCCCACGTGGTGTGGATGAGGAGGCAGATGGCAGGGCCTGTGCATTTCTGTGCTTGAGTGGGCCTTGAAAGTGGTTCAGCAACCA
GGAAGAAGTGTTCATTCCTCGACAACAACATCCCCGGGCTCTGGTGACTTGGCTGACACTGGATGGCCCTGGAATGAAAAAGGCAAAGAG
GCAAAATGTGCAAGGGCCCATCTGGAACCAAGGCCCCATAAAAGCGACTGTCACTCGGTCCCAGACACCAGAGCAAGCTCAAGACCCAGC
AGTGGGACAGCCAGACAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCTGCTCCTCCTCCTCCTCGCCAGCCTGA
CCAGTGGCTCTGTTTTCCCACAACAGTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTT
TTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCCCCTGGAGAAGAACGCCCCCGTCTTGC
TGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTATGACCAGTACCTGCACCGCTTTGCTG
CGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGTGGACCACCAGACAGGCCCCATTGTGT
GGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGATGATACCCTGTGACTTCCTCATCCCGG
TCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACAGAGGCCCTGATGAGGGGAA
AATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAGGCTGCTGCCACATAAGAGTGGAGCTG
GGAAAGCAGCTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAAC
TTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTC
CTCCCCGGAGCCGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGC
TGGTCTCCCCCAGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTT

>35593_35593_6_HAMP-GPI_HAMP_chr19_35773570_ENST00000598398_GPI_chr19_34884153_ENST00000586425_length(amino acids)=267AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HAMP-GPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HAMP-GPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HAMP-GPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource