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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HAND2-SLC30A9 (FusionGDB2 ID:35596)

Fusion Gene Summary for HAND2-SLC30A9

Fusion gene summary

Fusion gene information	Fusion gene name: HAND2-SLC30A9
	Fusion gene ID: 35596
		Hgene	Tgene
	Gene symbol	HAND2	SLC30A9
	Gene ID	9464	10463
	Gene name	heart and neural crest derivatives expressed 2	solute carrier family 30 member 9
	Synonyms	DHAND2\|Hed\|Thing2\|bHLHa26\|dHand	BILAPES\|C4orf1\|GAC63\|HUEL\|ZNT9
	Cytomap	4q34.1	4p13
	Type of gene	protein-coding	protein-coding
	Description	heart- and neural crest derivatives-expressed protein 2basic helix-loop-helix transcription factor HAND2class A basic helix-loop-helix protein 26deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2	zinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9
	Modification date	20200313	20200313
	UniProtAcc	P61296	.
	Ensembl transtripts involved in fusion gene	ENST00000359562, ENST00000505300,	ENST00000264451,
Fusion gene scores	* DoF score	2 X 3 X 1=6	5 X 10 X 3=150
	# samples	3	8
	** MAII score	log2(3/6*10)=2.32192809488736	log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HAND2 [Title/Abstract] AND SLC30A9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HAND2(174449886)-SLC30A9(42041003), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HAND2	GO:0010613	positive regulation of cardiac muscle hypertrophy	24161931
Hgene	HAND2	GO:0034103	regulation of tissue remodeling	24161931
Hgene	HAND2	GO:0045944	positive regulation of transcription by RNA polymerase II	15486975\|16280598\|24161931
Hgene	HAND2	GO:2000679	positive regulation of transcription regulatory region DNA binding	16280598

Fusion gene breakpoints across HAND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC30A9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-SP-A6QI-01A	HAND2	chr4	174449886	-	SLC30A9	chr4	42041003	+
ChimerDB4	PCPG	TCGA-SP-A6QI	HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+

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Fusion Gene ORF analysis for HAND2-SLC30A9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000359562	ENST00000264451	HAND2	chr4	174449886	-	SLC30A9	chr4	42041003	+
In-frame	ENST00000359562	ENST00000264451	HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+
intron-3CDS	ENST00000505300	ENST00000264451	HAND2	chr4	174449886	-	SLC30A9	chr4	42041003	+
intron-3CDS	ENST00000505300	ENST00000264451	HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000359562

HAND2

chr4

174449886

ENST00000264451

SLC30A9

chr4

42041003

6864

1495

829

2532

567

ENST00000359562

HAND2

chr4

174449885

ENST00000264451

SLC30A9

chr4

42041002

6864

1495

829

2532

567

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000359562	ENST00000264451	HAND2	chr4	174449886	-	SLC30A9	chr4	42041003	+	0.000338761	0.9996612
ENST00000359562	ENST00000264451	HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+	0.000338761	0.9996612

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Fusion Genomic Features for HAND2-SLC30A9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+	1.71E-08	1
HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+	1.71E-08	1
HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+	1.71E-08	1
HAND2	chr4	174449885	-	SLC30A9	chr4	42041002	+	1.71E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HAND2-SLC30A9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:174449886/chr4:42041003)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HAND2 P61296	.
FUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HAND2

chr4:174449885

chr4:42041002

ENST00000359562

21_32

185

218.0

Compositional bias

Note=Poly-Ala

Hgene

HAND2

chr4:174449886

chr4:42041003

ENST00000359562

21_32

185

218.0

Compositional bias

Note=Poly-Ala

Hgene

HAND2

chr4:174449885

chr4:42041002

ENST00000359562

99_151

185

218.0

Domain

bHLH

Hgene

HAND2

chr4:174449886

chr4:42041003

ENST00000359562

99_151

185

218.0

Domain

bHLH

Tgene

SLC30A9

chr4:174449885

chr4:42041002

ENST00000264451

462_466

223

569.0

Motif

Note=LXXLL motif

Tgene

SLC30A9

chr4:174449886

chr4:42041003

ENST00000264451

462_466

223

569.0

Motif

Note=LXXLL motif

Tgene

SLC30A9

chr4:174449885

chr4:42041002

ENST00000264451

239_259

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449885

chr4:42041002

ENST00000264451

314_334

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449885

chr4:42041002

ENST00000264451

342_362

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449885

chr4:42041002

ENST00000264451

392_412

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449885

chr4:42041002

ENST00000264451

424_444

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449886

chr4:42041003

ENST00000264451

239_259

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449886

chr4:42041003

ENST00000264451

314_334

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449886

chr4:42041003

ENST00000264451

342_362

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449886

chr4:42041003

ENST00000264451

392_412

223

569.0

Transmembrane

Helical

Tgene

SLC30A9

chr4:174449886

chr4:42041003

ENST00000264451

424_444

223

569.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HAND2-SLC30A9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>35596_35596_1_HAND2-SLC30A9_HAND2_chr4_174449885_ENST00000359562_SLC30A9_chr4_42041002_ENST00000264451_length(transcript)=6864nt_BP=1495nt
AGCTGTACATGGAGATCTTGCTGGGAAAATCCGCTTGCTCCCCTCACGTCGTCCAGCCCAGGAGAACCACCGCCGTCACCCCGGAGCTTC
CTCGGCCACCGCGCAGAGCCCTCCGAGAGCCCGAGCCGCGGTCTTCGAGCTCCAAGGCTCATTCAGGGCCCCAGATCCTTGCCCCGAAAG
GAGAGGATCTGAGAAAATGGATGCACTGAGACCTCTCTGAAAACCCTCCGAGAGAGCGCGAGAGGAGCGAGGACACGTTACTCGCAGCTA
AAATCACATTTAAGGACCAAAACAACAACAACCAAAAATTTCATTAAAACAATAAGCGCCCAAGAACCCAGATCGGGCTGGTGGGGGGAG
GGGAAGAGGCGGGAAGGGGAGGGTCGCACGGAGGTAGCTTTGCAGTGAGCAGTCGACCCCGCCGCCCCCCGGCACAGCTGGACCGGCTCC
TCCAGCCGCGGCTCAGACTCGCCCCTGGATTCCGGGTTAGCTTCGGTGCCAGGACCGCGGCCCGGGCTTGGATTCCCGAGACTCCGCGTA
CCAGCCTCGCGGGAGCCCCGGCACCTTTGTATGAGCACGAGAGGATTCTGCCTCCGCGCAGCAGCCCGGGAAGCAGGAGCCGAAGCGCGG
GCCGTGGAGCAAGGCGGGAACCGGAGGCGGCGGCGGCGGCGGCCAGGGGCGCACGGTGCCAGGACCAGCTCGCCGCGCCCCATGGGGAGC
CGGCGGCCGCAGCGCTGCTGAGGCGGGCCCGGCTGGCCAGGCGGGGGGACGGGGCCCGGGCTGCAGCAGCCCCCTCTGCGGCTGCCGGGC
GGGCCCGGGCGCCCGGGGGCTGGGGGGTGGGGGGTGGGGGAGGACGCCGAGCGCTGAGGCAGGGGCCCGGGCCGAGGGCGCGGCGGGGCT
GCGCGCACGCTGGGGCGCGTGGAGGGGCGCGGAGGGCGAAATGAGTCTGGTAGGTGGTTTTCCCCACCACCCGGTGGTGCACCACGAGGG
CTACCCGTTTGCCGCCGCCGCCGCCGCAGCTGCCGCCGCCGCCGCCAGCCGCTGCAGCCATGAGGAGAACCCCTACTTCCATGGCTGGCT
CATCGGCCACCCCGAGATGTCGCCCCCCGACTACAGCATGGCCCTGTCCTACAGCCCCGAGTATGCCAGCGGCGCCGCCGGCCTGGACCA
CTCCCATTACGGGGGGGTGCCGCCGGGCGCCGGGCCCCCGGGCCTGGGGGGGCCGCGCCCGGTGAAGCGCCGAGGCACCGCCAACCGCAA
GGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCCGAACTGCGCGAGTGCATCCCCAACGTACCCGCCGACACCAAACTCTCCAA
AATCAAGACCCTGCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAATGGCGAGGCGGAGGCCTT
CAAGGCAGAGATCAAGAAGACCGACGTGAAAGAGGAGAAGAGGAAGAAGGAGCTGCCACGCTCCAGAACAGCATCAGTGTTTTTTAAGGG
ACCAGGAAAAGTGGTGATGGTTGCAATTTGCATCAATGGATTAAACTGCTTCTTTAAATTTCTTGCCTGGATTTATACCGGTTCAGCAAG
TATGTTCTCAGAAGCTATACACTCATTATCTGATACTTGTAATCAGGGTTTACTAGCATTGGGCATCAGTAAGTCTGTTCAAACACCAGA
TCCTTCTCATCCGTACGGATTTTCAAATATGCGCTATATTTCTTCGCTAATTAGTGGTGTTGGTATTTTCATGATGGGTGCAGGACTATC
TTGGTACCATGGAGTCATGGGATTGCTTCATCCTCAACCAATAGAATCCCTTCTATGGGCATATTGTATTTTAGCAGGATCATTAGTATC
TGAAGGAGCAACACTTCTTGTTGCTGTAAATGAACTTCGTAGGAATGCTCGGGCTAAAGGAATGTCATTTTACAAGTATGTAATGGAAAG
TCGTGATCCTAGTACAAATGTGATATTATTGGAGGATACTGCTGCAGTCTTGGGAGTTATAATAGCAGCCACTTGCATGGGCCTTACTTC
TATAACAGGCAATCCACTGTATGACAGCCTAGGTTCTTTGGGTGTGGGCACCTTATTAGGCATGGTCTCAGCATTCCTCATCTACACTAA
CACAGAAGCACTCTTAGGGCGGTCCATCCAGCCAGAACAAGTACAACGGCTCACTGAACTCCTGGAGAATGACCCATCAGTAAGGGCAAT
TCATGATGTTAAAGCCACAGATCTGGGATTAGGTAAAGTAAGATTTAAGGCAGAAGTAGATTTTGATGGGCGAGTTGTTACAAGATCATA
TTTGGAAAAACAAGATTTTGACCAAATGTTACAAGAAATTCAAGAAGTGAAAACTCCTGAAGAACTAGAGACCTTTATGCTTAAACATGG
AGAAAATATTATTGATACTTTAGGAGCTGAAGTAGATAGACTTGAGAAGGAACTGAAAAAACGAAATCCTGAAGTTCGACATGTAGATTT
GGAGATACTGTGAGTTTGATGGAATGAATCACCTGGGTGGGGACCTTGGAAACAAGTTTGTCCGTCCACTCTACAAAGTTTCCTCCTCTC
CTACACTGAAAGACTCAGTGCCATGCAGAAGCCTTTTTTTTAAGATGAAGGAAATATTTTATGTAAAGAGCAACTCAGCAGGACACAGAA
CTAAAACTACTACTTACATCTAACAGACACACTACAAGTTGAATCAATTTGAAAATCATGTTTTTATGCTTCCATAGGGAACATTTTGGT
TATTTAAATTGTTCATAATGTCCCATATTTCACCTGTTCAGTGTATACTGTACTTTGCAATCATCTTTCCTTTTTTCACATTGGTAAAAA
TAAGTGGCATCCATAGGATCATGATTTTTAATTTGTTGCCTCTGAAGATTTCACTCCATCAAGATCTGCCAATCTTCAATATTCTGGCTA
AATCTTGGTATGTGGTTTTTAAACAGTCACTCCGTTTCAAAGTCTGTCTTTCCTTATAGAATGTGGAAATTATTTCTCCATACCTTGTGA
TTTTGACCTGAGTGCTAAGAGAATCACTCTCCTTACCTAGTTATCTACAAATGTTCATTCCAGAAATGTTTAGTTACTGAATTGAATGAA
GACATCTCAGTACACTCTTTTAGGTCATAGTAGTTGCCATTTTGTAAAATTTCTTTTTTCTTCTTTGCTTTTTTCCCCTTATTTGGTTTA
ATTTTTCTAATGTTAGGAGATATAGTCCTAGATATTTCCATGGGCCAGTGTGATGACTTTTTTTTAAATGAGGTTCAGTACCATAATGTT
TATTTACTGGAAGATAATGCATTTATAAGCATTTTAAAATTCTGTAAAGTGGGTTAGAAATATTTATAATTTTACAGGCAGGACAGCATT
TGACTTTTATTTAAAAGGCGGCACTACTTATGTAAATCTGAGCTGTGGGATATTTCTTGCTTTAAGAGAGAGACAGAATCTCTCACTGAA
ACTCATGGTCATGATTTTGTATAATATAGTTCATACTGTGTCTGTGAGTTTCTTCAGTTACAAATGGGCATTTAGTATAGTTATATTGAC
TATAACATGTAAGTAAATAGCTTTCTACTGACCCTAAGTTATCAAGGTGGAAAAAAAACATGCAATTCAGTAATTGAAAATGTGGTGAAA
AGCTGCAGCTGTCATCATCAAAACAACTCATAACATACTTTAAAATGTTCAGGTAGCAGTGAGCATTGTTCATATGAGAATGGCGGCTGG
GTGATCTCTTTGCTGAATTAATGAGTTCTTAACATGTGGACCCAACTGCCTGTGTGAGATCTGTGTCTTAAAACTTACTGGAATGGAAAT
CTATGAATTATTGCAAATTGTAATGCTGGAAACAAAAAATAAATCCTTGGTTAAAGGGTTTGTAATGGTGATTTTTGACCCAGAAATCTC
ATTTACTGGAAAATTGTGAGACTTTACGTTGGTGTATTTTTCTTTTTTTTTTTTTTACTATTACAGAGTATTTTGCATGCTGTACATTTT
AAGTGAAATAACATTCCAGTTTTATTTTTAAGATAGAAAATTGTTATATATATATATAATTTGATACTCTATTCTTACAGTTTCAAATTC
CTTATCCCTTCTTTACAAAAAAAACTTTTTTTTTACCTGTTATGATTTATTCTATACTTTTTTCTTCTTCCTTCCCCTTTCCCACTTGCC
ATTTATTACTTCATGTCATTGCCATATGAGAAAGTACCAAATTATATCCAGTTTCCTCCTAGTGATATTACTCTGAAAAATTTCACAAAG
CCAGACAAGAATAATTACTCATTTTTTTTCCCAAGACGACCCTCAAAGTTAATGTGCAGCAGGTATTCCAAATGGTAATTTTTTTTTTTT
AGGATTCCCTAATAAAAAAAAAAAAAATTCTGATATTTCTTTTTAAATCTGATTTTGGTTGAGGTCATACCATTCTTAAATAATAATTGA
AGGTTTATGTTGCCATCTTTTCTAATTCTGTTTTGCACTGATAAACTTACATAAAGTTTGTTTATGTAAAATAAGACATAAAGGAGTACA
ACATATCAAGGAATTTGAGTATTTATGTGGAATCAGGAAATTTTTCTAGAGTCACTGAATTTTCAAATCAGAGAATTTGGGCTGGATATG
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATTGCTTGAGCTCAGGAGGTCAAGACCAGCCTGGGCAACACA
GCGAGACCTCATCTCTACTAAAAAAAGTTAGCCGGGTGTGGTGGTGCTCACCTGTGTTAGTCCATTCTCACACTGCTATAAAGAAATACC
TGAGACTGAGTAATCAAAAAAAGAGCTTTAATTGGCTCATGGTTCTGCAGACTGAACAGGAAACATAGCAGCTTCTGCTTCTGGGGAGGC
CTCGGGAAACTTCATTCATGGCAGAATACGAAGGGGAAGCAGTCATAGCCAGAGGAAGAGCAAGAGGCGGGGATTGGGGGTAGGTGCCAC
ACTCTTGTAAACAACCAGATCTCATGAGAACTCACTATACAGTACCAAGAGGGGAAGGTGCTAAAGTATTCATGAGAACTCCACCCCCGT
GATCCAGTCATCTCCCACCAGGCCCTACCTCCAACATGGGATTACAATTCGACATGAGATTTGGTGGGGACAAAGATCCAAAGCATATCA
GCATCTGTAGTCACAGCTACTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCCAGAGGTCGAGGCTGCAATGAGCTATGATCATGCCA
CTCCAGCCTGAATGACAGAGTGAGATCCTGTCTCAAAAAGAGAATTTGGGTCTCTTTCTCCAAAAATAAGGCTATATTTAGTTTTTCAGG
TTTCTTGTTATTTTACCAAATTAATGTTTCTTACTTTGTATCTACTTTGGCATATAGCATTTGAGTATTAAAGCATATAAATCATTTTTA
AGGAAAATATTCTCTGCAGGAGAATAATTACAAAAATAATACTGGACAGAGGAGGGGCAGTCAAGGGTCCATGATTGATTCCTTCTTGCC
CAAAACTAAAATCTAGGATTTATCAAAGGTGAGGTATACAGTGGTCCCTGACTTATAATGGTTGCACTTAAGAATTTTTATGATGGGTTT
ATTGGCACATAACCCAATAATAAGTAAAAAGCATCTGTACCTACTTTTAGCTTTGGCTGAGAATGGATCTCTAATTCACTGTAAGTAGCA
GTCCCCAAACTATATAAGGTGGCACAGTTTTCATCATGGCAGTGGGAGGATGAGGGGTGGAGTGTTTTTGTTTTTTTTGTTTTTTTTTGA
GACAGAGTTTCGTTCTTGTTGCCCAGGCTGGAGTGCACTGGCACAATTGCAGCTCACCGCAACCTTCACCTCCCGATTCAAGTGATTCTC
CTGCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTGTATTTCTGGTTTAGACAAGGTTTCTCCATGTTGG
TCAGGCTGGTCTTGAACTGCCGACCTCAGGTGATCCGCCCTCCTCGGCTTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCTCCGG
TGATCTGTTTTTAAGTGGAGTATCCTGGGGGCCTATAGTATCCAACTCCAAAGAGGTAAGTTCCTGAACATACACTAAAGAACCTGTGAG
ATAAGATCAGACGGAAAAATTTTCAAATTTTTTCAAAAGCAAAGGTAATCCCTGCATACATCCTCCTACACACACACACATAGTGCAAAG
TGAATAACAAAATGTCATAAGGCTTGAGTTTTTGGTATATGGCTTTCAGTGTTACCTTATCTCATAATTTAGGTAATGATTTTTGCTAAA
ATGATAACCATCTAAAGAGTGCCTAAGTTTTAAGTCTCGTAACTTTTTGAGGAAGAATGCTGGGAACTACAGAAAACTGCATAGGCATTT
AGAATTTGTATTATCTTCTTAGACTGCATTTGTCAAGCTTTGGCAGCATTTCTTTTAAATGTGATGAACCCCAATTTGCCAAACTGTCAG
AAGTCAGTGAAGCAAAGAATCGAAGGTAAAATGTTGATTCAAAGATTGTCTCCCCTAAATCCTTCATTTCTTTCTCTGAAATGGAACTTT
GGAAGCCATTTATATAGATTAGTCTGACAGCCTTTATATTTGCATGTAAGTTTACTTGCATCCTTAGACTTGGCTTTATGCAAAAAGAAA
ATTTTTATTCGTTATATTGTATTTCATCTGTCTGATTTCCCTGGCACATTAAGATGGTCCTGGTCCCTCAGGATACTTTTTCCCTTAATA

>35596_35596_1_HAND2-SLC30A9_HAND2_chr4_174449885_ENST00000359562_SLC30A9_chr4_42041002_ENST00000264451_length(amino acids)=567AA_BP=222
MGGGGWGRTPSAEAGARAEGAAGLRARWGAWRGAEGEMSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEM
SPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRL
ATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAI
HSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLL
VAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGMVSAFLIYTNTEALLG
RSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIIDT

--------------------------------------------------------------
>35596_35596_2_HAND2-SLC30A9_HAND2_chr4_174449886_ENST00000359562_SLC30A9_chr4_42041003_ENST00000264451_length(transcript)=6864nt_BP=1495nt
AGCTGTACATGGAGATCTTGCTGGGAAAATCCGCTTGCTCCCCTCACGTCGTCCAGCCCAGGAGAACCACCGCCGTCACCCCGGAGCTTC
CTCGGCCACCGCGCAGAGCCCTCCGAGAGCCCGAGCCGCGGTCTTCGAGCTCCAAGGCTCATTCAGGGCCCCAGATCCTTGCCCCGAAAG
GAGAGGATCTGAGAAAATGGATGCACTGAGACCTCTCTGAAAACCCTCCGAGAGAGCGCGAGAGGAGCGAGGACACGTTACTCGCAGCTA
AAATCACATTTAAGGACCAAAACAACAACAACCAAAAATTTCATTAAAACAATAAGCGCCCAAGAACCCAGATCGGGCTGGTGGGGGGAG
GGGAAGAGGCGGGAAGGGGAGGGTCGCACGGAGGTAGCTTTGCAGTGAGCAGTCGACCCCGCCGCCCCCCGGCACAGCTGGACCGGCTCC
TCCAGCCGCGGCTCAGACTCGCCCCTGGATTCCGGGTTAGCTTCGGTGCCAGGACCGCGGCCCGGGCTTGGATTCCCGAGACTCCGCGTA
CCAGCCTCGCGGGAGCCCCGGCACCTTTGTATGAGCACGAGAGGATTCTGCCTCCGCGCAGCAGCCCGGGAAGCAGGAGCCGAAGCGCGG
GCCGTGGAGCAAGGCGGGAACCGGAGGCGGCGGCGGCGGCGGCCAGGGGCGCACGGTGCCAGGACCAGCTCGCCGCGCCCCATGGGGAGC
CGGCGGCCGCAGCGCTGCTGAGGCGGGCCCGGCTGGCCAGGCGGGGGGACGGGGCCCGGGCTGCAGCAGCCCCCTCTGCGGCTGCCGGGC
GGGCCCGGGCGCCCGGGGGCTGGGGGGTGGGGGGTGGGGGAGGACGCCGAGCGCTGAGGCAGGGGCCCGGGCCGAGGGCGCGGCGGGGCT
GCGCGCACGCTGGGGCGCGTGGAGGGGCGCGGAGGGCGAAATGAGTCTGGTAGGTGGTTTTCCCCACCACCCGGTGGTGCACCACGAGGG
CTACCCGTTTGCCGCCGCCGCCGCCGCAGCTGCCGCCGCCGCCGCCAGCCGCTGCAGCCATGAGGAGAACCCCTACTTCCATGGCTGGCT
CATCGGCCACCCCGAGATGTCGCCCCCCGACTACAGCATGGCCCTGTCCTACAGCCCCGAGTATGCCAGCGGCGCCGCCGGCCTGGACCA
CTCCCATTACGGGGGGGTGCCGCCGGGCGCCGGGCCCCCGGGCCTGGGGGGGCCGCGCCCGGTGAAGCGCCGAGGCACCGCCAACCGCAA
GGAGCGGCGCAGGACTCAGAGCATCAACAGCGCCTTCGCCGAACTGCGCGAGTGCATCCCCAACGTACCCGCCGACACCAAACTCTCCAA
AATCAAGACCCTGCGCCTGGCCACCAGCTACATCGCCTACCTCATGGACCTGCTGGCCAAGGACGACCAGAATGGCGAGGCGGAGGCCTT
CAAGGCAGAGATCAAGAAGACCGACGTGAAAGAGGAGAAGAGGAAGAAGGAGCTGCCACGCTCCAGAACAGCATCAGTGTTTTTTAAGGG
ACCAGGAAAAGTGGTGATGGTTGCAATTTGCATCAATGGATTAAACTGCTTCTTTAAATTTCTTGCCTGGATTTATACCGGTTCAGCAAG
TATGTTCTCAGAAGCTATACACTCATTATCTGATACTTGTAATCAGGGTTTACTAGCATTGGGCATCAGTAAGTCTGTTCAAACACCAGA
TCCTTCTCATCCGTACGGATTTTCAAATATGCGCTATATTTCTTCGCTAATTAGTGGTGTTGGTATTTTCATGATGGGTGCAGGACTATC
TTGGTACCATGGAGTCATGGGATTGCTTCATCCTCAACCAATAGAATCCCTTCTATGGGCATATTGTATTTTAGCAGGATCATTAGTATC
TGAAGGAGCAACACTTCTTGTTGCTGTAAATGAACTTCGTAGGAATGCTCGGGCTAAAGGAATGTCATTTTACAAGTATGTAATGGAAAG
TCGTGATCCTAGTACAAATGTGATATTATTGGAGGATACTGCTGCAGTCTTGGGAGTTATAATAGCAGCCACTTGCATGGGCCTTACTTC
TATAACAGGCAATCCACTGTATGACAGCCTAGGTTCTTTGGGTGTGGGCACCTTATTAGGCATGGTCTCAGCATTCCTCATCTACACTAA
CACAGAAGCACTCTTAGGGCGGTCCATCCAGCCAGAACAAGTACAACGGCTCACTGAACTCCTGGAGAATGACCCATCAGTAAGGGCAAT
TCATGATGTTAAAGCCACAGATCTGGGATTAGGTAAAGTAAGATTTAAGGCAGAAGTAGATTTTGATGGGCGAGTTGTTACAAGATCATA
TTTGGAAAAACAAGATTTTGACCAAATGTTACAAGAAATTCAAGAAGTGAAAACTCCTGAAGAACTAGAGACCTTTATGCTTAAACATGG
AGAAAATATTATTGATACTTTAGGAGCTGAAGTAGATAGACTTGAGAAGGAACTGAAAAAACGAAATCCTGAAGTTCGACATGTAGATTT
GGAGATACTGTGAGTTTGATGGAATGAATCACCTGGGTGGGGACCTTGGAAACAAGTTTGTCCGTCCACTCTACAAAGTTTCCTCCTCTC
CTACACTGAAAGACTCAGTGCCATGCAGAAGCCTTTTTTTTAAGATGAAGGAAATATTTTATGTAAAGAGCAACTCAGCAGGACACAGAA
CTAAAACTACTACTTACATCTAACAGACACACTACAAGTTGAATCAATTTGAAAATCATGTTTTTATGCTTCCATAGGGAACATTTTGGT
TATTTAAATTGTTCATAATGTCCCATATTTCACCTGTTCAGTGTATACTGTACTTTGCAATCATCTTTCCTTTTTTCACATTGGTAAAAA
TAAGTGGCATCCATAGGATCATGATTTTTAATTTGTTGCCTCTGAAGATTTCACTCCATCAAGATCTGCCAATCTTCAATATTCTGGCTA
AATCTTGGTATGTGGTTTTTAAACAGTCACTCCGTTTCAAAGTCTGTCTTTCCTTATAGAATGTGGAAATTATTTCTCCATACCTTGTGA
TTTTGACCTGAGTGCTAAGAGAATCACTCTCCTTACCTAGTTATCTACAAATGTTCATTCCAGAAATGTTTAGTTACTGAATTGAATGAA
GACATCTCAGTACACTCTTTTAGGTCATAGTAGTTGCCATTTTGTAAAATTTCTTTTTTCTTCTTTGCTTTTTTCCCCTTATTTGGTTTA
ATTTTTCTAATGTTAGGAGATATAGTCCTAGATATTTCCATGGGCCAGTGTGATGACTTTTTTTTAAATGAGGTTCAGTACCATAATGTT
TATTTACTGGAAGATAATGCATTTATAAGCATTTTAAAATTCTGTAAAGTGGGTTAGAAATATTTATAATTTTACAGGCAGGACAGCATT
TGACTTTTATTTAAAAGGCGGCACTACTTATGTAAATCTGAGCTGTGGGATATTTCTTGCTTTAAGAGAGAGACAGAATCTCTCACTGAA
ACTCATGGTCATGATTTTGTATAATATAGTTCATACTGTGTCTGTGAGTTTCTTCAGTTACAAATGGGCATTTAGTATAGTTATATTGAC
TATAACATGTAAGTAAATAGCTTTCTACTGACCCTAAGTTATCAAGGTGGAAAAAAAACATGCAATTCAGTAATTGAAAATGTGGTGAAA
AGCTGCAGCTGTCATCATCAAAACAACTCATAACATACTTTAAAATGTTCAGGTAGCAGTGAGCATTGTTCATATGAGAATGGCGGCTGG
GTGATCTCTTTGCTGAATTAATGAGTTCTTAACATGTGGACCCAACTGCCTGTGTGAGATCTGTGTCTTAAAACTTACTGGAATGGAAAT
CTATGAATTATTGCAAATTGTAATGCTGGAAACAAAAAATAAATCCTTGGTTAAAGGGTTTGTAATGGTGATTTTTGACCCAGAAATCTC
ATTTACTGGAAAATTGTGAGACTTTACGTTGGTGTATTTTTCTTTTTTTTTTTTTTACTATTACAGAGTATTTTGCATGCTGTACATTTT
AAGTGAAATAACATTCCAGTTTTATTTTTAAGATAGAAAATTGTTATATATATATATAATTTGATACTCTATTCTTACAGTTTCAAATTC
CTTATCCCTTCTTTACAAAAAAAACTTTTTTTTTACCTGTTATGATTTATTCTATACTTTTTTCTTCTTCCTTCCCCTTTCCCACTTGCC
ATTTATTACTTCATGTCATTGCCATATGAGAAAGTACCAAATTATATCCAGTTTCCTCCTAGTGATATTACTCTGAAAAATTTCACAAAG
CCAGACAAGAATAATTACTCATTTTTTTTCCCAAGACGACCCTCAAAGTTAATGTGCAGCAGGTATTCCAAATGGTAATTTTTTTTTTTT
AGGATTCCCTAATAAAAAAAAAAAAAATTCTGATATTTCTTTTTAAATCTGATTTTGGTTGAGGTCATACCATTCTTAAATAATAATTGA
AGGTTTATGTTGCCATCTTTTCTAATTCTGTTTTGCACTGATAAACTTACATAAAGTTTGTTTATGTAAAATAAGACATAAAGGAGTACA
ACATATCAAGGAATTTGAGTATTTATGTGGAATCAGGAAATTTTTCTAGAGTCACTGAATTTTCAAATCAGAGAATTTGGGCTGGATATG
GTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATTGCTTGAGCTCAGGAGGTCAAGACCAGCCTGGGCAACACA
GCGAGACCTCATCTCTACTAAAAAAAGTTAGCCGGGTGTGGTGGTGCTCACCTGTGTTAGTCCATTCTCACACTGCTATAAAGAAATACC
TGAGACTGAGTAATCAAAAAAAGAGCTTTAATTGGCTCATGGTTCTGCAGACTGAACAGGAAACATAGCAGCTTCTGCTTCTGGGGAGGC
CTCGGGAAACTTCATTCATGGCAGAATACGAAGGGGAAGCAGTCATAGCCAGAGGAAGAGCAAGAGGCGGGGATTGGGGGTAGGTGCCAC
ACTCTTGTAAACAACCAGATCTCATGAGAACTCACTATACAGTACCAAGAGGGGAAGGTGCTAAAGTATTCATGAGAACTCCACCCCCGT
GATCCAGTCATCTCCCACCAGGCCCTACCTCCAACATGGGATTACAATTCGACATGAGATTTGGTGGGGACAAAGATCCAAAGCATATCA
GCATCTGTAGTCACAGCTACTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCCCCAGAGGTCGAGGCTGCAATGAGCTATGATCATGCCA
CTCCAGCCTGAATGACAGAGTGAGATCCTGTCTCAAAAAGAGAATTTGGGTCTCTTTCTCCAAAAATAAGGCTATATTTAGTTTTTCAGG
TTTCTTGTTATTTTACCAAATTAATGTTTCTTACTTTGTATCTACTTTGGCATATAGCATTTGAGTATTAAAGCATATAAATCATTTTTA
AGGAAAATATTCTCTGCAGGAGAATAATTACAAAAATAATACTGGACAGAGGAGGGGCAGTCAAGGGTCCATGATTGATTCCTTCTTGCC
CAAAACTAAAATCTAGGATTTATCAAAGGTGAGGTATACAGTGGTCCCTGACTTATAATGGTTGCACTTAAGAATTTTTATGATGGGTTT
ATTGGCACATAACCCAATAATAAGTAAAAAGCATCTGTACCTACTTTTAGCTTTGGCTGAGAATGGATCTCTAATTCACTGTAAGTAGCA
GTCCCCAAACTATATAAGGTGGCACAGTTTTCATCATGGCAGTGGGAGGATGAGGGGTGGAGTGTTTTTGTTTTTTTTGTTTTTTTTTGA
GACAGAGTTTCGTTCTTGTTGCCCAGGCTGGAGTGCACTGGCACAATTGCAGCTCACCGCAACCTTCACCTCCCGATTCAAGTGATTCTC
CTGCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCACCACACCCGGCTAATTTTGTATTTCTGGTTTAGACAAGGTTTCTCCATGTTGG
TCAGGCTGGTCTTGAACTGCCGACCTCAGGTGATCCGCCCTCCTCGGCTTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCTCCGG
TGATCTGTTTTTAAGTGGAGTATCCTGGGGGCCTATAGTATCCAACTCCAAAGAGGTAAGTTCCTGAACATACACTAAAGAACCTGTGAG
ATAAGATCAGACGGAAAAATTTTCAAATTTTTTCAAAAGCAAAGGTAATCCCTGCATACATCCTCCTACACACACACACATAGTGCAAAG
TGAATAACAAAATGTCATAAGGCTTGAGTTTTTGGTATATGGCTTTCAGTGTTACCTTATCTCATAATTTAGGTAATGATTTTTGCTAAA
ATGATAACCATCTAAAGAGTGCCTAAGTTTTAAGTCTCGTAACTTTTTGAGGAAGAATGCTGGGAACTACAGAAAACTGCATAGGCATTT
AGAATTTGTATTATCTTCTTAGACTGCATTTGTCAAGCTTTGGCAGCATTTCTTTTAAATGTGATGAACCCCAATTTGCCAAACTGTCAG
AAGTCAGTGAAGCAAAGAATCGAAGGTAAAATGTTGATTCAAAGATTGTCTCCCCTAAATCCTTCATTTCTTTCTCTGAAATGGAACTTT
GGAAGCCATTTATATAGATTAGTCTGACAGCCTTTATATTTGCATGTAAGTTTACTTGCATCCTTAGACTTGGCTTTATGCAAAAAGAAA
ATTTTTATTCGTTATATTGTATTTCATCTGTCTGATTTCCCTGGCACATTAAGATGGTCCTGGTCCCTCAGGATACTTTTTCCCTTAATA

>35596_35596_2_HAND2-SLC30A9_HAND2_chr4_174449886_ENST00000359562_SLC30A9_chr4_42041003_ENST00000264451_length(amino acids)=567AA_BP=222
MGGGGWGRTPSAEAGARAEGAAGLRARWGAWRGAEGEMSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEM
SPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRL
ATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAI
HSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLL
VAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGMVSAFLIYTNTEALLG
RSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIIDT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HAND2-SLC30A9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HAND2-SLC30A9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HAND2-SLC30A9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source