FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HARS-FAM53C (FusionGDB2 ID:35619)

Fusion Gene Summary for HARS-FAM53C

check button Fusion gene summary
Fusion gene informationFusion gene name: HARS-FAM53C
Fusion gene ID: 35619
HgeneTgene
Gene symbol

HARS

FAM53C

Gene ID

3035

51307

Gene namehistidyl-tRNA synthetase 1family with sequence similarity 53 member C
SynonymsCMT2W|HARS|HRS|USH3BC5orf6
Cytomap

5q31.3

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionhistidine--tRNA ligase, cytoplasmicHisRSJo-1 antigenhistidine translaseprotein FAM53Cputative nuclear protein
Modification date2020031320200313
UniProtAcc.

Q9NYF3

Ensembl transtripts involved in fusion geneENST00000307633, ENST00000415192, 
ENST00000431330, ENST00000438307, 
ENST00000457527, ENST00000504156, 
ENST00000448240, ENST00000504366, 
ENST00000239906, ENST00000507506, 
ENST00000434981, ENST00000513056, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 8 X 4=192
# samples 77
** MAII scorelog2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HARS [Title/Abstract] AND FAM53C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHARS(140070440)-FAM53C(137676873), # samples:3
Anticipated loss of major functional domain due to fusion event.HARS-FAM53C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHARS

GO:0006427

histidyl-tRNA aminoacylation

29235198


check buttonFusion gene breakpoints across HARS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FAM53C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RC-01AHARSchr5

140070440

-FAM53Cchr5

137676873

+
ChimerDB4BRCATCGA-E9-A1RC-01AHARSchr5

140070440

-FAM53Cchr5

137680514

+
ChimerDB4BRCATCGA-E9-A1RCHARSchr5

140070439

-FAM53Cchr5

137676872

+
ChimerDB4BRCATCGA-E9-A1RCHARSchr5

140070439

-FAM53Cchr5

137680513

+


Top

Fusion Gene ORF analysis for HARS-FAM53C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000307633ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000307633ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000307633ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000307633ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000415192ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000415192ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000415192ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000415192ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000431330ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000431330ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000431330ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000431330ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000438307ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000438307ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000438307ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000438307ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000457527ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000457527ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000457527ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000457527ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000504156ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000504156ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-3UTRENST00000504156ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-3UTRENST00000504156ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-5UTRENST00000307633ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000307633ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000307633ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000307633ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000307633ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000307633ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000415192ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000415192ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000415192ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000415192ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000415192ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000415192ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000431330ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000431330ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000431330ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000431330ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000431330ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000431330ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000438307ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000438307ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000438307ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000438307ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000438307ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000438307ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000457527ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000457527ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000457527ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000457527ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000457527ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000457527ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000504156ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000504156ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000504156ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000504156ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-5UTRENST00000504156ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-5UTRENST00000504156ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000307633ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000307633ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000307633ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-intronENST00000307633ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-intronENST00000415192ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000415192ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000415192ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-intronENST00000415192ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-intronENST00000431330ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000431330ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000431330ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-intronENST00000431330ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-intronENST00000438307ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000438307ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000438307ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-intronENST00000438307ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-intronENST00000457527ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000457527ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000457527ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-intronENST00000457527ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
5CDS-intronENST00000504156ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5CDS-intronENST00000504156ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5CDS-intronENST00000504156ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5CDS-intronENST00000504156ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
5UTR-3CDSENST00000448240ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
5UTR-3CDSENST00000448240ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
5UTR-3UTRENST00000448240ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
5UTR-3UTRENST00000448240ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
5UTR-3UTRENST00000448240ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
5UTR-3UTRENST00000448240ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
5UTR-5UTRENST00000448240ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-5UTRENST00000448240ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
5UTR-5UTRENST00000448240ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-5UTRENST00000448240ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
5UTR-5UTRENST00000448240ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-5UTRENST00000448240ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
5UTR-intronENST00000448240ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
5UTR-intronENST00000448240ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
5UTR-intronENST00000448240ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
5UTR-intronENST00000448240ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+
Frame-shiftENST00000307633ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
Frame-shiftENST00000307633ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
Frame-shiftENST00000415192ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
Frame-shiftENST00000415192ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
Frame-shiftENST00000431330ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
Frame-shiftENST00000431330ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
Frame-shiftENST00000438307ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
Frame-shiftENST00000438307ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
Frame-shiftENST00000457527ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
Frame-shiftENST00000457527ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
Frame-shiftENST00000504156ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
Frame-shiftENST00000504156ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
intron-3CDSENST00000504366ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137680514

+
intron-3CDSENST00000504366ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137680513

+
intron-3UTRENST00000504366ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137680514

+
intron-3UTRENST00000504366ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137680513

+
intron-3UTRENST00000504366ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137680514

+
intron-3UTRENST00000504366ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137680513

+
intron-5UTRENST00000504366ENST00000239906HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-5UTRENST00000504366ENST00000239906HARSchr5

140070439

-FAM53Cchr5

137676872

+
intron-5UTRENST00000504366ENST00000434981HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-5UTRENST00000504366ENST00000434981HARSchr5

140070439

-FAM53Cchr5

137676872

+
intron-5UTRENST00000504366ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-5UTRENST00000504366ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137676872

+
intron-intronENST00000504366ENST00000507506HARSchr5

140070440

-FAM53Cchr5

137676873

+
intron-intronENST00000504366ENST00000507506HARSchr5

140070439

-FAM53Cchr5

137676872

+
intron-intronENST00000504366ENST00000513056HARSchr5

140070440

-FAM53Cchr5

137680514

+
intron-intronENST00000504366ENST00000513056HARSchr5

140070439

-FAM53Cchr5

137680513

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HARS-FAM53C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HARSchr5140070439-FAM53Cchr5137680513+0.0083802750.9916197
HARSchr5140070439-FAM53Cchr5137680513+0.0083802750.9916197
HARSchr5140070439-FAM53Cchr5137676872+0.0031663580.9968336
HARSchr5140070439-FAM53Cchr5137676872+0.0031663580.9968336
HARSchr5140070439-FAM53Cchr5137680513+0.0083802750.9916197
HARSchr5140070439-FAM53Cchr5137680513+0.0083802750.9916197
HARSchr5140070439-FAM53Cchr5137676872+0.0031663580.9968336
HARSchr5140070439-FAM53Cchr5137676872+0.0031663580.9968336

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HARS-FAM53C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:140070440/:137676873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM53C

Q9NYF3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for HARS-FAM53C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for HARS-FAM53C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HARS-FAM53C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HARS-FAM53C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource