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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HAUS8-CARS (FusionGDB2 ID:35660)

Fusion Gene Summary for HAUS8-CARS

check button Fusion gene summary
Fusion gene informationFusion gene name: HAUS8-CARS
Fusion gene ID: 35660
HgeneTgene
Gene symbol

HAUS8

CARS

Gene ID

93323

833

Gene nameHAUS augmin like complex subunit 8cysteinyl-tRNA synthetase 1
SynonymsDGT4|HICE1|NY-SAR-48CARS|CYSRS|MGC:11246
Cytomap

19p13.11

11p15.4

Type of geneprotein-codingprotein-coding
DescriptionHAUS augmin-like complex subunit 8HEC1/NDC80 interacting, centrosome associated 1HEC1/NDC80-interacting centrosome-associated protein 1Hec1-interacting and centrosome-associated 1sarcoma antigen NY-SAR-48cysteine--tRNA ligase, cytoplasmiccysteine tRNA ligase 1, cytoplasmiccysteine translase
Modification date2020031320200313
UniProtAcc

Q9BT25

Q9HA77

Ensembl transtripts involved in fusion geneENST00000253669, ENST00000448593, 
ENST00000593360, 		ENST00000397114, 
ENST00000401769, ENST00000470221, 
ENST00000278224, ENST00000380525, 
ENST00000397111, 
Fusion gene scores* DoF score8 X 6 X 7=33611 X 12 X 6=792
# samples 812
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HAUS8 [Title/Abstract] AND CARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHAUS8(17179841)-CARS(3040497), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCARS

GO:0006423

cysteinyl-tRNA aminoacylation

10908348|17303165


check buttonFusion gene breakpoints across HAUS8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMZ-01AHAUS8chr19

17179841

-CARSchr11

3040497

-


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Fusion Gene ORF analysis for HAUS8-CARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253669ENST00000397114HAUS8chr19

17179841

-CARSchr11

3040497

-
5CDS-intronENST00000253669ENST00000401769HAUS8chr19

17179841

-CARSchr11

3040497

-
5CDS-intronENST00000253669ENST00000470221HAUS8chr19

17179841

-CARSchr11

3040497

-
5CDS-intronENST00000448593ENST00000397114HAUS8chr19

17179841

-CARSchr11

3040497

-
5CDS-intronENST00000448593ENST00000401769HAUS8chr19

17179841

-CARSchr11

3040497

-
5CDS-intronENST00000448593ENST00000470221HAUS8chr19

17179841

-CARSchr11

3040497

-
5UTR-3CDSENST00000593360ENST00000278224HAUS8chr19

17179841

-CARSchr11

3040497

-
5UTR-3CDSENST00000593360ENST00000380525HAUS8chr19

17179841

-CARSchr11

3040497

-
5UTR-3CDSENST00000593360ENST00000397111HAUS8chr19

17179841

-CARSchr11

3040497

-
5UTR-intronENST00000593360ENST00000397114HAUS8chr19

17179841

-CARSchr11

3040497

-
5UTR-intronENST00000593360ENST00000401769HAUS8chr19

17179841

-CARSchr11

3040497

-
5UTR-intronENST00000593360ENST00000470221HAUS8chr19

17179841

-CARSchr11

3040497

-
In-frameENST00000253669ENST00000278224HAUS8chr19

17179841

-CARSchr11

3040497

-
In-frameENST00000253669ENST00000380525HAUS8chr19

17179841

-CARSchr11

3040497

-
In-frameENST00000253669ENST00000397111HAUS8chr19

17179841

-CARSchr11

3040497

-
In-frameENST00000448593ENST00000278224HAUS8chr19

17179841

-CARSchr11

3040497

-
In-frameENST00000448593ENST00000380525HAUS8chr19

17179841

-CARSchr11

3040497

-
In-frameENST00000448593ENST00000397111HAUS8chr19

17179841

-CARSchr11

3040497

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253669HAUS8chr1917179841-ENST00000380525CARSchr113040497-17603381911567458
ENST00000253669HAUS8chr1917179841-ENST00000397111CARSchr113040497-17603381911567458
ENST00000253669HAUS8chr1917179841-ENST00000278224CARSchr113040497-17613381911501436
ENST00000448593HAUS8chr1917179841-ENST00000380525CARSchr113040497-17723502031579458
ENST00000448593HAUS8chr1917179841-ENST00000397111CARSchr113040497-17723502031579458
ENST00000448593HAUS8chr1917179841-ENST00000278224CARSchr113040497-17733502031513436

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253669ENST00000380525HAUS8chr1917179841-CARSchr113040497-0.003847830.9961521
ENST00000253669ENST00000397111HAUS8chr1917179841-CARSchr113040497-0.003847830.9961521
ENST00000253669ENST00000278224HAUS8chr1917179841-CARSchr113040497-0.0045458590.9954541
ENST00000448593ENST00000380525HAUS8chr1917179841-CARSchr113040497-0.0037677250.9962322
ENST00000448593ENST00000397111HAUS8chr1917179841-CARSchr113040497-0.0037677250.9962322
ENST00000448593ENST00000278224HAUS8chr1917179841-CARSchr113040497-0.0044463620.9955537

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Fusion Genomic Features for HAUS8-CARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HAUS8-CARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17179841/chr11:3040497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HAUS8

Q9BT25

CARS

Q9HA77

FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCARSchr19:17179841chr11:3040497ENST00000278224922406_410339727.0MotifNote='KMSKS' region
TgeneCARSchr19:17179841chr11:3040497ENST00000397111922406_410339749.0MotifNote='KMSKS' region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHAUS8chr19:17179841chr11:3040497ENST00000253669-311156_20849411.0Coiled coilOntology_term=ECO:0000255
HgeneHAUS8chr19:17179841chr11:3040497ENST00000448593-311156_20849410.0Coiled coilOntology_term=ECO:0000255
HgeneHAUS8chr19:17179841chr11:3040497ENST00000593360-210156_2080350.0Coiled coilOntology_term=ECO:0000255
TgeneCARSchr19:17179841chr11:3040497ENST0000027822492257_67339727.0MotifNote='HIGH' region
TgeneCARSchr19:17179841chr11:3040497ENST000003805251023406_410422832.0MotifNote='KMSKS' region
TgeneCARSchr19:17179841chr11:3040497ENST00000380525102357_67422832.0MotifNote='HIGH' region
TgeneCARSchr19:17179841chr11:3040497ENST0000039711192257_67339749.0MotifNote='HIGH' region


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Fusion Gene Sequence for HAUS8-CARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35660_35660_1_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000253669_CARS_chr11_3040497_ENST00000278224_length(transcript)=1761nt_BP=338nt
GCGAGACCAAGTGCGAGGGGAGGACAGGCGAAGCGCGCGTCTGGGGCCGCGCTCTCCACACTTAGCCGGCGCTGCCTCACGCCTCGCAGC
CACCCCTCCTGCGTCTCCACAAATGGTCCGACCCGCAAGCAAGGGGGCGGGTCCGGCTTTGAAAAGCCGGCGGGTCGGGCCTTGAGGTGG
AAGGCGGGAAAATGGCGGATTCCTCGGGGCGAGGCGCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGATA
AAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGGTCGTCCGGGCTGGCATATCG
AGTGCTCGGCCATGGCAGGCACCCTCCTAGGGGCTTCGATGGACATTCACGGAGGTGGGTTCGACCTCCGGTTCCCCCACCATGACAATG
AGCTGGCACAGTCGGAGGCCTACTTTGAAAACGACTGCTGGGTCAGGTACTTCCTGCACACAGGCCACCTGACCATTGCAGGCTGCAAAA
TGTCAAAGTCACTAAAAAACTTCATCACCATTAAAGATGCCTTGAAAAAGCACTCAGCACGGCAGTTGCGGCTGGCCTTCCTCATGCACT
CGTGGAAGGACACCCTGGACTACTCCAGCAACACCATGGAGTCAGCGCTTCAATATGAGAAGTTCTTGAATGAGTTTTTCTTAAATGTGA
AAGATATCCTTCGCGCTCCTGTTGACATCACTGGTCAGTTTGAGAAGTGGGGAGAAGAAGAAGCAGAACTGAATAAGAACTTTTATGACA
AGAAGACAGCAATTCACAAAGCCCTCTGTGACAATGTTGACACCCGCACCGTCATGGAAGAGATGCGGGCCTTGGTCAGTCAGTGCAACC
TCTATATGGCAGCCCGGAAAGCCGTGAGGAAGAGGCCCAACCAGGCTCTGCTGGAGAACATCGCCCTGTACCTCACCCATATGCTGAAGA
TCTTTGGGGCCGTAGAAGAGGACAGCTCCCTGGGATTCCCGGTCGGAGGGCCTGGAACCAGCCTCAGTCTCGAGGCCACAGTCATGCCCT
ACCTTCAGGTGTTATCAGAATTCCGAGAAGGAGTGCGGAAGATTGCCCGAGAGCAAAAAGTCCCTGAGATTCTGCAGCTCAGCGATGCCC
TGCGGGACAACATCCTGCCCGAGCTTGGGGTGCGGTTTGAAGACCACGAAGGACTGCCCACAGTGGTGAAACTGGTAGACAGAAACACCT
TATTAAAAGAGAGAGAAGAAAAGAGACGGGTTGAAGAGGAGAAGAGGAAGAAGAAAGAGGAGGCGGCCCGGAGGAAACAGGAACAAGAAG
CAGCAAAGCTGGCCAAGATGAAGATTCCCCCCAGTGAGATGTTCTTGTCAGAAACCGACAAATACTCCAAGTTTGATGAAAATGTAAGCA
TGGTCTGCCCACACATGACATGGAGGGCAAAGAGCTCAGCAAAGGGCAAGCCAAGAAGCTGAAGAAGCTCTTCGAGGCTCAGGAGAAGCT
CTACAAGGAATATCTGCAGATGGCCCAGAATGGAAGCTTCCAGTGAGGGGGCACAGGACTGACTTTTTAAACCATTGTGGACTAGTGGCT
GCTGTCTGCCTCAGTGACAATGTCCCAGCGCTCCTATCATGTTTACAGTCACCCTTGGGTCCTAAATTAAGAGTTGTGTTCATGTAGGTT

>35660_35660_1_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000253669_CARS_chr11_3040497_ENST00000278224_length(amino acids)=436AA_BP=49
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQ
SEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDIL
RAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGA
VEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKE

--------------------------------------------------------------
>35660_35660_2_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000253669_CARS_chr11_3040497_ENST00000380525_length(transcript)=1760nt_BP=338nt
GCGAGACCAAGTGCGAGGGGAGGACAGGCGAAGCGCGCGTCTGGGGCCGCGCTCTCCACACTTAGCCGGCGCTGCCTCACGCCTCGCAGC
CACCCCTCCTGCGTCTCCACAAATGGTCCGACCCGCAAGCAAGGGGGCGGGTCCGGCTTTGAAAAGCCGGCGGGTCGGGCCTTGAGGTGG
AAGGCGGGAAAATGGCGGATTCCTCGGGGCGAGGCGCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGATA
AAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGGTCGTCCGGGCTGGCATATCG
AGTGCTCGGCCATGGCAGGCACCCTCCTAGGGGCTTCGATGGACATTCACGGAGGTGGGTTCGACCTCCGGTTCCCCCACCATGACAATG
AGCTGGCACAGTCGGAGGCCTACTTTGAAAACGACTGCTGGGTCAGGTACTTCCTGCACACAGGCCACCTGACCATTGCAGGCTGCAAAA
TGTCAAAGTCACTAAAAAACTTCATCACCATTAAAGATGCCTTGAAAAAGCACTCAGCACGGCAGTTGCGGCTGGCCTTCCTCATGCACT
CGTGGAAGGACACCCTGGACTACTCCAGCAACACCATGGAGTCAGCGCTTCAATATGAGAAGTTCTTGAATGAGTTTTTCTTAAATGTGA
AAGATATCCTTCGCGCTCCTGTTGACATCACTGGTCAGTTTGAGAAGTGGGGAGAAGAAGAAGCAGAACTGAATAAGAACTTTTATGACA
AGAAGACAGCAATTCACAAAGCCCTCTGTGACAATGTTGACACCCGCACCGTCATGGAAGAGATGCGGGCCTTGGTCAGTCAGTGCAACC
TCTATATGGCAGCCCGGAAAGCCGTGAGGAAGAGGCCCAACCAGGCTCTGCTGGAGAACATCGCCCTGTACCTCACCCATATGCTGAAGA
TCTTTGGGGCCGTAGAAGAGGACAGCTCCCTGGGATTCCCGGTCGGAGGGCCTGGAACCAGCCTCAGTCTCGAGGCCACAGTCATGCCCT
ACCTTCAGGTGTTATCAGAATTCCGAGAAGGAGTGCGGAAGATTGCCCGAGAGCAAAAAGTCCCTGAGATTCTGCAGCTCAGCGATGCCC
TGCGGGACAACATCCTGCCCGAGCTTGGGGTGCGGTTTGAAGACCACGAAGGACTGCCCACAGTGGTGAAACTGGTAGACAGAAACACCT
TATTAAAAGAGAGAGAAGAAAAGAGACGGGTTGAAGAGGAGAAGAGGAAGAAGAAAGAGGAGGCGGCCCGGAGGAAACAGGAACAAGAAG
CAGCAAAGCTGGCCAAGATGAAGATTCCCCCCAGTGAGATGTTCTTGTCAGAAACCGACAAATACTCCAAGTTTGATGAAAATGGTCTGC
CCACACATGACATGGAGGGCAAAGAGCTCAGCAAAGGGCAAGCCAAGAAGCTGAAGAAGCTCTTCGAGGCTCAGGAGAAGCTCTACAAGG
AATATCTGCAGATGGCCCAGAATGGAAGCTTCCAGTGAGGGGGCACAGGACTGACTTTTTAAACCATTGTGGACTAGTGGCTGCTGTCTG
CCTCAGTGACAATGTCCCAGCGCTCCTATCATGTTTACAGTCACCCTTGGGTCCTAAATTAAGAGTTGTGTTCATGTAGGTTCGTGTCGT

>35660_35660_2_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000253669_CARS_chr11_3040497_ENST00000380525_length(amino acids)=458AA_BP=49
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQ
SEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDIL
RAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGA
VEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKE
REEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQ

--------------------------------------------------------------
>35660_35660_3_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000253669_CARS_chr11_3040497_ENST00000397111_length(transcript)=1760nt_BP=338nt
GCGAGACCAAGTGCGAGGGGAGGACAGGCGAAGCGCGCGTCTGGGGCCGCGCTCTCCACACTTAGCCGGCGCTGCCTCACGCCTCGCAGC
CACCCCTCCTGCGTCTCCACAAATGGTCCGACCCGCAAGCAAGGGGGCGGGTCCGGCTTTGAAAAGCCGGCGGGTCGGGCCTTGAGGTGG
AAGGCGGGAAAATGGCGGATTCCTCGGGGCGAGGCGCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCAAGAAGAAGGATA
AAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGGTCGTCCGGGCTGGCATATCG
AGTGCTCGGCCATGGCAGGCACCCTCCTAGGGGCTTCGATGGACATTCACGGAGGTGGGTTCGACCTCCGGTTCCCCCACCATGACAATG
AGCTGGCACAGTCGGAGGCCTACTTTGAAAACGACTGCTGGGTCAGGTACTTCCTGCACACAGGCCACCTGACCATTGCAGGCTGCAAAA
TGTCAAAGTCACTAAAAAACTTCATCACCATTAAAGATGCCTTGAAAAAGCACTCAGCACGGCAGTTGCGGCTGGCCTTCCTCATGCACT
CGTGGAAGGACACCCTGGACTACTCCAGCAACACCATGGAGTCAGCGCTTCAATATGAGAAGTTCTTGAATGAGTTTTTCTTAAATGTGA
AAGATATCCTTCGCGCTCCTGTTGACATCACTGGTCAGTTTGAGAAGTGGGGAGAAGAAGAAGCAGAACTGAATAAGAACTTTTATGACA
AGAAGACAGCAATTCACAAAGCCCTCTGTGACAATGTTGACACCCGCACCGTCATGGAAGAGATGCGGGCCTTGGTCAGTCAGTGCAACC
TCTATATGGCAGCCCGGAAAGCCGTGAGGAAGAGGCCCAACCAGGCTCTGCTGGAGAACATCGCCCTGTACCTCACCCATATGCTGAAGA
TCTTTGGGGCCGTAGAAGAGGACAGCTCCCTGGGATTCCCGGTCGGAGGGCCTGGAACCAGCCTCAGTCTCGAGGCCACAGTCATGCCCT
ACCTTCAGGTGTTATCAGAATTCCGAGAAGGAGTGCGGAAGATTGCCCGAGAGCAAAAAGTCCCTGAGATTCTGCAGCTCAGCGATGCCC
TGCGGGACAACATCCTGCCCGAGCTTGGGGTGCGGTTTGAAGACCACGAAGGACTGCCCACAGTGGTGAAACTGGTAGACAGAAACACCT
TATTAAAAGAGAGAGAAGAAAAGAGACGGGTTGAAGAGGAGAAGAGGAAGAAGAAAGAGGAGGCGGCCCGGAGGAAACAGGAACAAGAAG
CAGCAAAGCTGGCCAAGATGAAGATTCCCCCCAGTGAGATGTTCTTGTCAGAAACCGACAAATACTCCAAGTTTGATGAAAATGGTCTGC
CCACACATGACATGGAGGGCAAAGAGCTCAGCAAAGGGCAAGCCAAGAAGCTGAAGAAGCTCTTCGAGGCTCAGGAGAAGCTCTACAAGG
AATATCTGCAGATGGCCCAGAATGGAAGCTTCCAGTGAGGGGGCACAGGACTGACTTTTTAAACCATTGTGGACTAGTGGCTGCTGTCTG
CCTCAGTGACAATGTCCCAGCGCTCCTATCATGTTTACAGTCACCCTTGGGTCCTAAATTAAGAGTTGTGTTCATGTAGGTTCGTGTCGT

>35660_35660_3_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000253669_CARS_chr11_3040497_ENST00000397111_length(amino acids)=458AA_BP=49
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQ
SEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDIL
RAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGA
VEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKE
REEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQ

--------------------------------------------------------------
>35660_35660_4_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000448593_CARS_chr11_3040497_ENST00000278224_length(transcript)=1773nt_BP=350nt
CGCCGATGGTGGGCGAGACCAAGTGCGAGGGGAGGACAGGCGAAGCGCGCGTCTGGGGCCGCGCTCTCCACACTTAGCCGGCGCTGCCTC
ACGCCTCGCAGCCACCCCTCCTGCGTCTCCACAAATGGTCCGACCCGCAAGCAAGGGGGCGGGTCCGGCTTTGAAAAGCCGGCGGGTCGG
GCCTTGAGGTGGAAGGCGGGAAAATGGCGGATTCCTCGGGGCGAGGCGCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCA
AGAAGAAGGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGGTCGTCCGG
GCTGGCATATCGAGTGCTCGGCCATGGCAGGCACCCTCCTAGGGGCTTCGATGGACATTCACGGAGGTGGGTTCGACCTCCGGTTCCCCC
ACCATGACAATGAGCTGGCACAGTCGGAGGCCTACTTTGAAAACGACTGCTGGGTCAGGTACTTCCTGCACACAGGCCACCTGACCATTG
CAGGCTGCAAAATGTCAAAGTCACTAAAAAACTTCATCACCATTAAAGATGCCTTGAAAAAGCACTCAGCACGGCAGTTGCGGCTGGCCT
TCCTCATGCACTCGTGGAAGGACACCCTGGACTACTCCAGCAACACCATGGAGTCAGCGCTTCAATATGAGAAGTTCTTGAATGAGTTTT
TCTTAAATGTGAAAGATATCCTTCGCGCTCCTGTTGACATCACTGGTCAGTTTGAGAAGTGGGGAGAAGAAGAAGCAGAACTGAATAAGA
ACTTTTATGACAAGAAGACAGCAATTCACAAAGCCCTCTGTGACAATGTTGACACCCGCACCGTCATGGAAGAGATGCGGGCCTTGGTCA
GTCAGTGCAACCTCTATATGGCAGCCCGGAAAGCCGTGAGGAAGAGGCCCAACCAGGCTCTGCTGGAGAACATCGCCCTGTACCTCACCC
ATATGCTGAAGATCTTTGGGGCCGTAGAAGAGGACAGCTCCCTGGGATTCCCGGTCGGAGGGCCTGGAACCAGCCTCAGTCTCGAGGCCA
CAGTCATGCCCTACCTTCAGGTGTTATCAGAATTCCGAGAAGGAGTGCGGAAGATTGCCCGAGAGCAAAAAGTCCCTGAGATTCTGCAGC
TCAGCGATGCCCTGCGGGACAACATCCTGCCCGAGCTTGGGGTGCGGTTTGAAGACCACGAAGGACTGCCCACAGTGGTGAAACTGGTAG
ACAGAAACACCTTATTAAAAGAGAGAGAAGAAAAGAGACGGGTTGAAGAGGAGAAGAGGAAGAAGAAAGAGGAGGCGGCCCGGAGGAAAC
AGGAACAAGAAGCAGCAAAGCTGGCCAAGATGAAGATTCCCCCCAGTGAGATGTTCTTGTCAGAAACCGACAAATACTCCAAGTTTGATG
AAAATGTAAGCATGGTCTGCCCACACATGACATGGAGGGCAAAGAGCTCAGCAAAGGGCAAGCCAAGAAGCTGAAGAAGCTCTTCGAGGC
TCAGGAGAAGCTCTACAAGGAATATCTGCAGATGGCCCAGAATGGAAGCTTCCAGTGAGGGGGCACAGGACTGACTTTTTAAACCATTGT
GGACTAGTGGCTGCTGTCTGCCTCAGTGACAATGTCCCAGCGCTCCTATCATGTTTACAGTCACCCTTGGGTCCTAAATTAAGAGTTGTG

>35660_35660_4_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000448593_CARS_chr11_3040497_ENST00000278224_length(amino acids)=436AA_BP=49
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQ
SEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDIL
RAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGA
VEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKE

--------------------------------------------------------------
>35660_35660_5_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000448593_CARS_chr11_3040497_ENST00000380525_length(transcript)=1772nt_BP=350nt
CGCCGATGGTGGGCGAGACCAAGTGCGAGGGGAGGACAGGCGAAGCGCGCGTCTGGGGCCGCGCTCTCCACACTTAGCCGGCGCTGCCTC
ACGCCTCGCAGCCACCCCTCCTGCGTCTCCACAAATGGTCCGACCCGCAAGCAAGGGGGCGGGTCCGGCTTTGAAAAGCCGGCGGGTCGG
GCCTTGAGGTGGAAGGCGGGAAAATGGCGGATTCCTCGGGGCGAGGCGCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCA
AGAAGAAGGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGGTCGTCCGG
GCTGGCATATCGAGTGCTCGGCCATGGCAGGCACCCTCCTAGGGGCTTCGATGGACATTCACGGAGGTGGGTTCGACCTCCGGTTCCCCC
ACCATGACAATGAGCTGGCACAGTCGGAGGCCTACTTTGAAAACGACTGCTGGGTCAGGTACTTCCTGCACACAGGCCACCTGACCATTG
CAGGCTGCAAAATGTCAAAGTCACTAAAAAACTTCATCACCATTAAAGATGCCTTGAAAAAGCACTCAGCACGGCAGTTGCGGCTGGCCT
TCCTCATGCACTCGTGGAAGGACACCCTGGACTACTCCAGCAACACCATGGAGTCAGCGCTTCAATATGAGAAGTTCTTGAATGAGTTTT
TCTTAAATGTGAAAGATATCCTTCGCGCTCCTGTTGACATCACTGGTCAGTTTGAGAAGTGGGGAGAAGAAGAAGCAGAACTGAATAAGA
ACTTTTATGACAAGAAGACAGCAATTCACAAAGCCCTCTGTGACAATGTTGACACCCGCACCGTCATGGAAGAGATGCGGGCCTTGGTCA
GTCAGTGCAACCTCTATATGGCAGCCCGGAAAGCCGTGAGGAAGAGGCCCAACCAGGCTCTGCTGGAGAACATCGCCCTGTACCTCACCC
ATATGCTGAAGATCTTTGGGGCCGTAGAAGAGGACAGCTCCCTGGGATTCCCGGTCGGAGGGCCTGGAACCAGCCTCAGTCTCGAGGCCA
CAGTCATGCCCTACCTTCAGGTGTTATCAGAATTCCGAGAAGGAGTGCGGAAGATTGCCCGAGAGCAAAAAGTCCCTGAGATTCTGCAGC
TCAGCGATGCCCTGCGGGACAACATCCTGCCCGAGCTTGGGGTGCGGTTTGAAGACCACGAAGGACTGCCCACAGTGGTGAAACTGGTAG
ACAGAAACACCTTATTAAAAGAGAGAGAAGAAAAGAGACGGGTTGAAGAGGAGAAGAGGAAGAAGAAAGAGGAGGCGGCCCGGAGGAAAC
AGGAACAAGAAGCAGCAAAGCTGGCCAAGATGAAGATTCCCCCCAGTGAGATGTTCTTGTCAGAAACCGACAAATACTCCAAGTTTGATG
AAAATGGTCTGCCCACACATGACATGGAGGGCAAAGAGCTCAGCAAAGGGCAAGCCAAGAAGCTGAAGAAGCTCTTCGAGGCTCAGGAGA
AGCTCTACAAGGAATATCTGCAGATGGCCCAGAATGGAAGCTTCCAGTGAGGGGGCACAGGACTGACTTTTTAAACCATTGTGGACTAGT
GGCTGCTGTCTGCCTCAGTGACAATGTCCCAGCGCTCCTATCATGTTTACAGTCACCCTTGGGTCCTAAATTAAGAGTTGTGTTCATGTA

>35660_35660_5_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000448593_CARS_chr11_3040497_ENST00000380525_length(amino acids)=458AA_BP=49
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQ
SEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDIL
RAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGA
VEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKE
REEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQ

--------------------------------------------------------------
>35660_35660_6_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000448593_CARS_chr11_3040497_ENST00000397111_length(transcript)=1772nt_BP=350nt
CGCCGATGGTGGGCGAGACCAAGTGCGAGGGGAGGACAGGCGAAGCGCGCGTCTGGGGCCGCGCTCTCCACACTTAGCCGGCGCTGCCTC
ACGCCTCGCAGCCACCCCTCCTGCGTCTCCACAAATGGTCCGACCCGCAAGCAAGGGGGCGGGTCCGGCTTTGAAAAGCCGGCGGGTCGG
GCCTTGAGGTGGAAGGCGGGAAAATGGCGGATTCCTCGGGGCGAGGCGCTGGGAAGCCTGCAACCGGCCCCACAAATTCTAGCAGTGCCA
AGAAGAAGGATAAAAGAGTTCAAGGTGGAAGAGTGATTGAGTCCCGGTATCTGCAGTATGAAAAGAAGACAACCCAAAAGGGTCGTCCGG
GCTGGCATATCGAGTGCTCGGCCATGGCAGGCACCCTCCTAGGGGCTTCGATGGACATTCACGGAGGTGGGTTCGACCTCCGGTTCCCCC
ACCATGACAATGAGCTGGCACAGTCGGAGGCCTACTTTGAAAACGACTGCTGGGTCAGGTACTTCCTGCACACAGGCCACCTGACCATTG
CAGGCTGCAAAATGTCAAAGTCACTAAAAAACTTCATCACCATTAAAGATGCCTTGAAAAAGCACTCAGCACGGCAGTTGCGGCTGGCCT
TCCTCATGCACTCGTGGAAGGACACCCTGGACTACTCCAGCAACACCATGGAGTCAGCGCTTCAATATGAGAAGTTCTTGAATGAGTTTT
TCTTAAATGTGAAAGATATCCTTCGCGCTCCTGTTGACATCACTGGTCAGTTTGAGAAGTGGGGAGAAGAAGAAGCAGAACTGAATAAGA
ACTTTTATGACAAGAAGACAGCAATTCACAAAGCCCTCTGTGACAATGTTGACACCCGCACCGTCATGGAAGAGATGCGGGCCTTGGTCA
GTCAGTGCAACCTCTATATGGCAGCCCGGAAAGCCGTGAGGAAGAGGCCCAACCAGGCTCTGCTGGAGAACATCGCCCTGTACCTCACCC
ATATGCTGAAGATCTTTGGGGCCGTAGAAGAGGACAGCTCCCTGGGATTCCCGGTCGGAGGGCCTGGAACCAGCCTCAGTCTCGAGGCCA
CAGTCATGCCCTACCTTCAGGTGTTATCAGAATTCCGAGAAGGAGTGCGGAAGATTGCCCGAGAGCAAAAAGTCCCTGAGATTCTGCAGC
TCAGCGATGCCCTGCGGGACAACATCCTGCCCGAGCTTGGGGTGCGGTTTGAAGACCACGAAGGACTGCCCACAGTGGTGAAACTGGTAG
ACAGAAACACCTTATTAAAAGAGAGAGAAGAAAAGAGACGGGTTGAAGAGGAGAAGAGGAAGAAGAAAGAGGAGGCGGCCCGGAGGAAAC
AGGAACAAGAAGCAGCAAAGCTGGCCAAGATGAAGATTCCCCCCAGTGAGATGTTCTTGTCAGAAACCGACAAATACTCCAAGTTTGATG
AAAATGGTCTGCCCACACATGACATGGAGGGCAAAGAGCTCAGCAAAGGGCAAGCCAAGAAGCTGAAGAAGCTCTTCGAGGCTCAGGAGA
AGCTCTACAAGGAATATCTGCAGATGGCCCAGAATGGAAGCTTCCAGTGAGGGGGCACAGGACTGACTTTTTAAACCATTGTGGACTAGT
GGCTGCTGTCTGCCTCAGTGACAATGTCCCAGCGCTCCTATCATGTTTACAGTCACCCTTGGGTCCTAAATTAAGAGTTGTGTTCATGTA

>35660_35660_6_HAUS8-CARS_HAUS8_chr19_17179841_ENST00000448593_CARS_chr11_3040497_ENST00000397111_length(amino acids)=458AA_BP=49
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQ
SEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDIL
RAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGA
VEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKE
REEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HAUS8-CARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HAUS8-CARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HAUS8-CARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource