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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HBP1-PIK3CG (FusionGDB2 ID:35714)

Fusion Gene Summary for HBP1-PIK3CG

check button Fusion gene summary
Fusion gene informationFusion gene name: HBP1-PIK3CG
Fusion gene ID: 35714
HgeneTgene
Gene symbol

HBP1

PIK3CG

Gene ID

26959

5294

Gene nameHMG-box transcription factor 1phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms-PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K
Cytomap

7q22.3

7q22.3

Type of geneprotein-codingprotein-coding
DescriptionHMG box-containing protein 1high mobility group box transcription factor 1phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform1-phosphatidylinositol 3-kinasePI3-kinase subunit gammaphosphatidylinositol 3 kinase gamma, p110 gammaphosphatidylinositol 3-kinase catalytic 110-kD gammaphosphatidylinosit
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000461963, ENST00000222574, 
ENST00000468410, ENST00000485846, 
ENST00000359195, ENST00000440650, 
ENST00000496166, ENST00000466738, 
Fusion gene scores* DoF score11 X 9 X 6=5943 X 2 X 3=18
# samples 133
** MAII scorelog2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HBP1 [Title/Abstract] AND PIK3CG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHBP1(106826917)-PIK3CG(106545554), # samples:1
Anticipated loss of major functional domain due to fusion event.HBP1-PIK3CG seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
HBP1-PIK3CG seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HBP1-PIK3CG seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HBP1-PIK3CG seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePIK3CG

GO:0007186

G protein-coupled receptor signaling pathway

12507995

TgenePIK3CG

GO:0014065

phosphatidylinositol 3-kinase signaling

12507995

TgenePIK3CG

GO:0016310

phosphorylation

25327288

TgenePIK3CG

GO:0043406

positive regulation of MAP kinase activity

12507995

TgenePIK3CG

GO:0051897

positive regulation of protein kinase B signaling

12507995


check buttonFusion gene breakpoints across HBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIK3CG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2BM-01AHBP1chr7

106826917

+PIK3CGchr7

106545554

+


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Fusion Gene ORF analysis for HBP1-PIK3CG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000461963ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-3CDSENST00000461963ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-3CDSENST00000461963ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
3UTR-intronENST00000461963ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
5CDS-intronENST00000222574ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
5CDS-intronENST00000468410ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
5CDS-intronENST00000485846ENST00000466738HBP1chr7

106826917

+PIK3CGchr7

106545554

+
Frame-shiftENST00000222574ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
Frame-shiftENST00000468410ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
Frame-shiftENST00000485846ENST00000359195HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000222574ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000222574ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000468410ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000468410ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000485846ENST00000440650HBP1chr7

106826917

+PIK3CGchr7

106545554

+
In-frameENST00000485846ENST00000496166HBP1chr7

106826917

+PIK3CGchr7

106545554

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000468410HBP1chr7106826917+ENST00000440650PIK3CGchr7106545554+144773413747244
ENST00000468410HBP1chr7106826917+ENST00000496166PIK3CGchr7106545554+275873413747244
ENST00000222574HBP1chr7106826917+ENST00000440650PIK3CGchr7106545554+1551838186851221
ENST00000222574HBP1chr7106826917+ENST00000496166PIK3CGchr7106545554+2862838186851221
ENST00000485846HBP1chr7106826917+ENST00000440650PIK3CGchr7106545554+203613235211336271
ENST00000485846HBP1chr7106826917+ENST00000496166PIK3CGchr7106545554+334713235211336271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000468410ENST00000440650HBP1chr7106826917+PIK3CGchr7106545554+0.0047277880.9952722
ENST00000468410ENST00000496166HBP1chr7106826917+PIK3CGchr7106545554+0.0023226410.9976774
ENST00000222574ENST00000440650HBP1chr7106826917+PIK3CGchr7106545554+0.0075784030.99242157
ENST00000222574ENST00000496166HBP1chr7106826917+PIK3CGchr7106545554+0.0044263760.99557364
ENST00000485846ENST00000440650HBP1chr7106826917+PIK3CGchr7106545554+0.011381850.98861814
ENST00000485846ENST00000496166HBP1chr7106826917+PIK3CGchr7106545554+0.0054301050.99456984

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Fusion Genomic Features for HBP1-PIK3CG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HBP1chr7106826917+PIK3CGchr7106545553+2.40E-050.99997604
HBP1chr7106826917+PIK3CGchr7106545553+2.40E-050.99997604

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HBP1-PIK3CG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:106826917/chr7:106545554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511156_161217515.0Compositional biasNote=Poly-Ser
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511197_200217515.0Compositional biasNote=Poly-Asp
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511156_161217515.0Compositional biasNote=Poly-Ser
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511197_200217515.0Compositional biasNote=Poly-Asp
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612156_161217515.0Compositional biasNote=Poly-Ser
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612197_200217515.0Compositional biasNote=Poly-Asp

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511434_502217515.0DNA bindingHMG box
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511434_502217515.0DNA bindingHMG box
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612434_502217515.0DNA bindingHMG box
HgeneHBP1chr7:106826917chr7:106545554ENST00000222574+511203_345217515.0DomainAXH
HgeneHBP1chr7:106826917chr7:106545554ENST00000468410+511203_345217515.0DomainAXH
HgeneHBP1chr7:106826917chr7:106545554ENST00000485846+612203_345217515.0DomainAXH
TgenePIK3CGchr7:106826917chr7:106545554ENST0000035919591119_2310101103.0Compositional biasNote=Poly-Arg
TgenePIK3CGchr7:106826917chr7:106545554ENST0000044065091119_2310101103.0Compositional biasNote=Poly-Arg
TgenePIK3CGchr7:106826917chr7:106545554ENST0000049616691119_2310101103.0Compositional biasNote=Poly-Arg
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911217_30910101103.0DomainPI3K-RBD
TgenePIK3CGchr7:106826917chr7:106545554ENST0000035919591134_14110101103.0DomainPI3K-ABD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911357_52110101103.0DomainC2 PI3K-type
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911541_72310101103.0DomainPIK helical
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911828_107310101103.0DomainPI3K/PI4K
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911217_30910101103.0DomainPI3K-RBD
TgenePIK3CGchr7:106826917chr7:106545554ENST0000044065091134_14110101103.0DomainPI3K-ABD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911357_52110101103.0DomainC2 PI3K-type
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911541_72310101103.0DomainPIK helical
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911828_107310101103.0DomainPI3K/PI4K
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911217_30910101103.0DomainPI3K-RBD
TgenePIK3CGchr7:106826917chr7:106545554ENST0000049616691134_14110101103.0DomainPI3K-ABD
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911357_52110101103.0DomainC2 PI3K-type
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911541_72310101103.0DomainPIK helical
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911828_107310101103.0DomainPI3K/PI4K
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911829_83810101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911864_87210101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000359195911961_96910101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911829_83810101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911864_87210101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000440650911961_96910101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911829_83810101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911864_87210101103.0Nucleotide bindingATP
TgenePIK3CGchr7:106826917chr7:106545554ENST00000496166911961_96910101103.0Nucleotide bindingATP


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Fusion Gene Sequence for HBP1-PIK3CG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35714_35714_1_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000222574_PIK3CG_chr7_106545554_ENST00000440650_length(transcript)=1551nt_BP=838nt
GGCGACGGGTTTGGTAAGTAGGAAAGTTTCGGTTGAGGAGTAAGAGCTGCCGCGGGAGCAGTAACCCGCGCGGGGGAGGCCGACGTCGGT
CGGAGAGGGGGTACGAGAGCTGCTGGTGGTGTTGTCGTGGCCGGAGCGGCCCGCGCCTGGGCTGCCGGCACTTCGCGGCAGTCAGAGCAC
CATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATG
AATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGAC
CTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGA
TCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCG
ACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCC
TATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACAC
GAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCT
TCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTT
CTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGA
GGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGT
TCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCAT
AGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCC
CTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTC
TGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCT
GGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAG

>35714_35714_1_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000222574_PIK3CG_chr7_106545554_ENST00000440650_length(amino acids)=221AA_BP=
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER

--------------------------------------------------------------
>35714_35714_2_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000222574_PIK3CG_chr7_106545554_ENST00000496166_length(transcript)=2862nt_BP=838nt
GGCGACGGGTTTGGTAAGTAGGAAAGTTTCGGTTGAGGAGTAAGAGCTGCCGCGGGAGCAGTAACCCGCGCGGGGGAGGCCGACGTCGGT
CGGAGAGGGGGTACGAGAGCTGCTGGTGGTGTTGTCGTGGCCGGAGCGGCCCGCGCCTGGGCTGCCGGCACTTCGCGGCAGTCAGAGCAC
CATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATG
AATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGAC
CTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGA
TCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCG
ACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCC
TATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACAC
GAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCT
TCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTT
CTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGA
GGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGT
TCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCAT
AGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCC
CTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTC
TGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCT
GGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAG
AAAAAGATGTAATCGTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAACATCTCCTTAGTGTCTGCAGGTGTTAGTGGTGTGCT
AAAAGCAAGGAAAGCGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTTGTCATGTATAACTGAGACACACAAACACAGCAGGA
GAAATCTAAACCGTTGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCCAGGGTTATGAATATGAAAAAATAGAGATGAGACTTTTTGTGTC
AACTCTGTCCACAAGAGTGAGTTATCTAGTATGATTAGTATAGCTTTCTCCAGCATGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATG
CCTGACATTTCTTCCCTTCCTTTTTCCCTGCCTCCCTTTTTCATCAATTGCGATGCTCCCACAACTCTTTACAGACTTGTGAAATCTTCA
AGAACACCTTTACTCTATAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAGGATTATTAGAATCTTAGGTACTTATTTGTAAAGAT
GTTTAGTGACTTTTTTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATGAATTAGTTTCCAAATGCCTTAATTTTAAACTTTGG
CCTGAACAGTTTTTTCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAATATTCCAAGTTAGGAAGAACACTACTTGCCTTATCC
ATTTCCCATTTAAAGGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAATAATTGAAATATCTTACTTTAAAAATATTTTCATC
TCTGAAATATCTCGTTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTAAATTATTTATAAAATATTTTGTAATTACCTGTAGC
TAATACATTACATAGAAAAAAACTATGTTAACAGTGTCTCTGTTTAAGTATAATCAGATATAAATATATACTTAATTTTTTAATTTTAAA
AATAGATACCTGTTTGACTTTGAGGTAGTCCAGACCTTTTCTTTTTTTTTTTTTTTTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCC
TGGCTGCAAAGAAGAATCAACAGGGACACTTTTTAAAAACACTCTTATCAGCCTGGGCAACACAGTGAGACTCCATCTCTTAAAAAAAAA
ATTAGCTGGGTATAGTGGTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTG

>35714_35714_2_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000222574_PIK3CG_chr7_106545554_ENST00000496166_length(amino acids)=221AA_BP=
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSS
WNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHER

--------------------------------------------------------------
>35714_35714_3_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000468410_PIK3CG_chr7_106545554_ENST00000440650_length(transcript)=1447nt_BP=734nt
AACCCCCAGGGGGTTGAGGGGAGGGGGAAGACGAAGCTTGAAAGACTTGGTAATGGCGACGGGTTTGTCAGAGCACCATAACATGGTGTG
GGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGA
GTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCA
GGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCA
AAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAG
TCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCC
ACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAG
TGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCA
CTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGA
TGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAA
AGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAAC
AAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAAC
TTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATG
TTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGA
ATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGA
ATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAGAAAAAGATGTAATC

>35714_35714_3_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000468410_PIK3CG_chr7_106545554_ENST00000440650_length(amino acids)=244AA_BP=
MRGGGRRSLKDLVMATGLSEHHNMVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQS
DPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSS

--------------------------------------------------------------
>35714_35714_4_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000468410_PIK3CG_chr7_106545554_ENST00000496166_length(transcript)=2758nt_BP=734nt
AACCCCCAGGGGGTTGAGGGGAGGGGGAAGACGAAGCTTGAAAGACTTGGTAATGGCGACGGGTTTGTCAGAGCACCATAACATGGTGTG
GGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAACTCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGA
GTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGATATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCA
GGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGCTGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCA
AAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATGAGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAG
TCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTGTACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCC
ACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTCATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAG
TGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAGATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCA
CTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCCCTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGA
TGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAATATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAA
AGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAAC
AAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCAAAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAAC
TTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTTCAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATG
TTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTAGGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGA
ATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCCCTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGA
ATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAATTTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAGAAAAAGATGTAATC
GTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAACATCTCCTTAGTGTCTGCAGGTGTTAGTGGTGTGCTAAAAGCAAGGAAAG
CGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTTGTCATGTATAACTGAGACACACAAACACAGCAGGAGAAATCTAAACCGT
TGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCCAGGGTTATGAATATGAAAAAATAGAGATGAGACTTTTTGTGTCAACTCTGTCCACAA
GAGTGAGTTATCTAGTATGATTAGTATAGCTTTCTCCAGCATGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATGCCTGACATTTCTTC
CCTTCCTTTTTCCCTGCCTCCCTTTTTCATCAATTGCGATGCTCCCACAACTCTTTACAGACTTGTGAAATCTTCAAGAACACCTTTACT
CTATAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAGGATTATTAGAATCTTAGGTACTTATTTGTAAAGATGTTTAGTGACTTTT
TTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATGAATTAGTTTCCAAATGCCTTAATTTTAAACTTTGGCCTGAACAGTTTTT
TCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAATATTCCAAGTTAGGAAGAACACTACTTGCCTTATCCATTTCCCATTTAAA
GGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAATAATTGAAATATCTTACTTTAAAAATATTTTCATCTCTGAAATATCTCG
TTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTAAATTATTTATAAAATATTTTGTAATTACCTGTAGCTAATACATTACATA
GAAAAAAACTATGTTAACAGTGTCTCTGTTTAAGTATAATCAGATATAAATATATACTTAATTTTTTAATTTTAAAAATAGATACCTGTT
TGACTTTGAGGTAGTCCAGACCTTTTCTTTTTTTTTTTTTTTTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCCTGGCTGCAAAGAAG
AATCAACAGGGACACTTTTTAAAAACACTCTTATCAGCCTGGGCAACACAGTGAGACTCCATCTCTTAAAAAAAAAATTAGCTGGGTATA
GTGGTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTGCAGAGAGTCATGAT

>35714_35714_4_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000468410_PIK3CG_chr7_106545554_ENST00000496166_length(amino acids)=244AA_BP=
MRGGGRRSLKDLVMATGLSEHHNMVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQS
DPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSS

--------------------------------------------------------------
>35714_35714_5_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000485846_PIK3CG_chr7_106545554_ENST00000440650_length(transcript)=2036nt_BP=1323nt
AAAAACAAGCCCGGAGTCCGGGCTGCGGTCACATGATGGGGGGAAGGGAGGGGAACGCGATGAATGGCGAAAGAGGGTGGGGGATGGACT
TGGCGTGAACCGGGAGGCACCGCTCTGTGTGACCCAAAGAGGAGGCTTGGCAGGCGATTCCAGTCTCCGCCTTTCAACCTATGCTGCCAC
CGCAGGCCGATTGAAACAAAACAAAACAAACCAGGCGAAGTGGACAGCCAGGTTTTTGTAGCTTTAAATGCTGCGTGCTGTCTAGGGTGT
TTCACTCTCCGCTGTGCACTCTACACTCGAGTTCATTCTTAGGGAGTTTTCAGCTACAGTCGTTTTTAGAAGGAGCACTGACAGCGAGGA
GTTTTGGGATGGTGGTTGATAACTAAGACAAAGTGCTGAAGAAATGATAGAAGTTGCAAAGAGACGTTAGTGTACTATACTTGGTGAATG
TTGGAAACTGCAGGACCTGCTGTAGGGAAGAAAAAAGTTCTAGCTGGAAAGAATGAGGAAACCAAAGAGCTCTGCAGAGGGAGGGGGAAG
ACAAGACAGACTGCAGCTGTGCTTCTGTGGACCCCAAGAACAGCACTGTTCATACACAGAGGATAGCTCTGAAGAGAGATACCTGTGTAG
TGCAGCTTCTAAATTTCATAATAAAGTCAGAGCACCATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAAC
TCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGAT
ATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGC
TGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATG
AGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTG
TACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTC
ATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAG
ATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCC
CTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAA
TATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGA
TGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCA
AAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTT
CAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTA
GGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCC
CTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAAT

>35714_35714_5_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000485846_PIK3CG_chr7_106545554_ENST00000440650_length(amino acids)=271AA_BP=
MQREGEDKTDCSCASVDPKNSTVHTQRIALKRDTCVVQLLNFIIKSEHHNMVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNEN
LPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSF
YNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHL

--------------------------------------------------------------
>35714_35714_6_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000485846_PIK3CG_chr7_106545554_ENST00000496166_length(transcript)=3347nt_BP=1323nt
AAAAACAAGCCCGGAGTCCGGGCTGCGGTCACATGATGGGGGGAAGGGAGGGGAACGCGATGAATGGCGAAAGAGGGTGGGGGATGGACT
TGGCGTGAACCGGGAGGCACCGCTCTGTGTGACCCAAAGAGGAGGCTTGGCAGGCGATTCCAGTCTCCGCCTTTCAACCTATGCTGCCAC
CGCAGGCCGATTGAAACAAAACAAAACAAACCAGGCGAAGTGGACAGCCAGGTTTTTGTAGCTTTAAATGCTGCGTGCTGTCTAGGGTGT
TTCACTCTCCGCTGTGCACTCTACACTCGAGTTCATTCTTAGGGAGTTTTCAGCTACAGTCGTTTTTAGAAGGAGCACTGACAGCGAGGA
GTTTTGGGATGGTGGTTGATAACTAAGACAAAGTGCTGAAGAAATGATAGAAGTTGCAAAGAGACGTTAGTGTACTATACTTGGTGAATG
TTGGAAACTGCAGGACCTGCTGTAGGGAAGAAAAAAGTTCTAGCTGGAAAGAATGAGGAAACCAAAGAGCTCTGCAGAGGGAGGGGGAAG
ACAAGACAGACTGCAGCTGTGCTTCTGTGGACCCCAAGAACAGCACTGTTCATACACAGAGGATAGCTCTGAAGAGAGATACCTGTGTAG
TGCAGCTTCTAAATTTCATAATAAAGTCAGAGCACCATAACATGGTGTGGGAAGTGAAGACAAATCAGATGCCTAATGCAGTACAGAAAC
TCCTGTTGGTGATGGACAAGAGAGCCTCAGGAATGAATGACTCATTGGAGTTGCTGCAGTGTAATGAGAATTTGCCATCTTCACCTGGAT
ATAACTCCTGTGATGAACACATGGAGCTTGATGACCTTCCTGAACTTCAGGCAGTTCAAAGTGATCCTACCCAATCTGGCATGTACCAGC
TGAGTTCAGATGTTTCACATCAAGAATACCCAAGATCATCTTGGAACCAAAATACCTCAGACATACCAGAAACTACTTACCGTGAAAATG
AGGTGGACTGGCTAACAGAATTGGCAAATATCGCGACCAGTCCACAAAGTCCACTGATGCAGTGCTCATTTTACAATAGATCATCTCCTG
TACACATCATAGCCACTAGCAAAAGTTTACATTCCTATGCACGCCCTCCACCAGTGTCCTCTTCTTCGAAGAGTGAACCAGCCTTCCCTC
ATCACCATTGGAAGGAGGAAACACCAGTAAGACACGAAAGGGCAAATAGTGAGTCAGAATCTGGCATTTTCTGCATGTCCTCCCTGTCAG
ATGATGATGATTTGGGATGGTGCAATTCCTGGCCTTCAACTGTCTGGCACTGTTTTTTGAAAGGACATCTGTGTTAAGGCTTATCTAGCC
CTTCGTCATCACACAAACCTACTGATCATCCTGTTCTCCATGATGCTGATGACAGGAATGCCCCAGTTAACAAGCAAAGAAGACATTGAA
TATATCCGGGATGCCCTCACAGTGGGGAAAAATGAGGAGGATGCTAAAAAGTATTTTCTTGATCAGATCGAAGTTTGCAGAGACAAAGGA
TGGACTGTGCAGTTTAATTGGTTTCTACATCTTGTTCTTGGCATCAAACAAGGAGAGAAACATTCAGCCTAATACTTTAGGCTAGAATCA
AAAACAAGTTAGTGTTCTATGGTTTAAATTAGCATAGCAATCATCGAACTTGGATTTCAAATGCAATAGACATTGTGAAAGCTGGCATTT
CAGAAGTATAGCTCTTTTCCTACCTGAACTCTTCCCTGGAGAAAAGATGTTGGCATTGCTGATTGTTTGGTTAAGCAATGTCCAGTGCTA
GGATTATTTGCAGGTTTGGTTTTTTCTCATTTGTCTGTGGCATTGGAGAATATTCTCGGTTTAAACAGACTAATGACTTCCTTATTGTCC
CTGATATTTTGACTATCTTACTATTGAGTGCTTCTGGAAATTCTTTGGAATAATTGATGACATCTATTTTCATCTGGGTTTAGTCTCAAT
TTTGGTTATCTTTGTGTTCCTCAAGCTCTTTAAAGAAAAAGATGTAATCGTTGTAACCTTTGTCTCATTCCTTAAATGATGCTTCCAAAC
ATCTCCTTAGTGTCTGCAGGTGTTAGTGGTGTGCTAAAAGCAAGGAAAGCGAGTTAGTCTTTTCAGTGTCTTTTGCAATTCAATTCTTTT
GTCATGTATAACTGAGACACACAAACACAGCAGGAGAAATCTAAACCGTTGTGCCTTGACCTTCCTCTGCTGGTCTTGTTCCAGGGTTAT
GAATATGAAAAAATAGAGATGAGACTTTTTGTGTCAACTCTGTCCACAAGAGTGAGTTATCTAGTATGATTAGTATAGCTTTCTCCAGCA
TGGCAGCAGGAAGTAACTACAGGGCCTCTTTTATGCCTGACATTTCTTCCCTTCCTTTTTCCCTGCCTCCCTTTTTCATCAATTGCGATG
CTCCCACAACTCTTTACAGACTTGTGAAATCTTCAAGAACACCTTTACTCTATAACTCAAAAATTAGTTGAAAAATAATTACTTCTCAAG
GATTATTAGAATCTTAGGTACTTATTTGTAAAGATGTTTAGTGACTTTTTTTTCAAGTATCTTATTAAAGGAGGCATTCTAGAAAATATG
AATTAGTTTCCAAATGCCTTAATTTTAAACTTTGGCCTGAACAGTTTTTTCTTTTTCTTAATGGAAGAAGATATTTAATATCTTAAAAAT
ATTCCAAGTTAGGAAGAACACTACTTGCCTTATCCATTTCCCATTTAAAGGACTTTTAAACTTTGACACATCCTTCAGATTTCCTGAAAA
TAATTGAAATATCTTACTTTAAAAATATTTTCATCTCTGAAATATCTCGTTATTTATTGGAGGTATTGTTTAACCTTAGAGAGACCATTA
AATTATTTATAAAATATTTTGTAATTACCTGTAGCTAATACATTACATAGAAAAAAACTATGTTAACAGTGTCTCTGTTTAAGTATAATC
AGATATAAATATATACTTAATTTTTTAATTTTAAAAATAGATACCTGTTTGACTTTGAGGTAGTCCAGACCTTTTCTTTTTTTTTTTTTT
TTTAATGTGTGCAAAAGCCCAAAGGTTCCTAAGCCTGGCTGCAAAGAAGAATCAACAGGGACACTTTTTAAAAACACTCTTATCAGCCTG
GGCAACACAGTGAGACTCCATCTCTTAAAAAAAAAATTAGCTGGGTATAGTGGTATGTGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGG
CAGGAGGATTGCCTGAGCCCAGGAGGTGGAAACTGCAGAGAGTCATGATCATGTCCTTACACTCCAGCCTGGATAACAGAGCGAGACCCT

>35714_35714_6_HBP1-PIK3CG_HBP1_chr7_106826917_ENST00000485846_PIK3CG_chr7_106545554_ENST00000496166_length(amino acids)=271AA_BP=
MQREGEDKTDCSCASVDPKNSTVHTQRIALKRDTCVVQLLNFIIKSEHHNMVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNEN
LPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSF
YNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGHL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HBP1-PIK3CG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HBP1-PIK3CG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HBP1-PIK3CG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource