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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HCG17-TRIM26 (FusionGDB2 ID:35753)

Fusion Gene Summary for HCG17-TRIM26

Fusion gene summary

Fusion gene information	Fusion gene name: HCG17-TRIM26
	Fusion gene ID: 35753
		Hgene	Tgene
	Gene symbol	HCG17	TRIM26
	Gene ID	414778	7726
	Gene name	HLA complex group 17	tripartite motif containing 26
	Synonyms	HCG18\|LINC00046\|NCRNA00046	AFP\|RNF95\|ZNF173
	Cytomap	6p22.1	6p22.1
	Type of gene	ncRNA	protein-coding
	Description	HLA complex group 17 (non-protein coding)long intergenic non-protein coding RNA 46	tripartite motif-containing protein 26RING finger protein 95acid finger proteinwidely expressed acid zinc finger proteinzinc finger protein 173
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000453558, ENST00000419861, ENST00000426984, ENST00000437311, ENST00000439480, ENST00000448760, ENST00000455160,	ENST00000437089, ENST00000454678, ENST00000487829, ENST00000327357, ENST00000383607, ENST00000396558, ENST00000415923, ENST00000422349, ENST00000425523, ENST00000425831, ENST00000427535, ENST00000428486, ENST00000432326, ENST00000433314, ENST00000436219, ENST00000438384, ENST00000438908, ENST00000439094, ENST00000445259, ENST00000447711, ENST00000450392, ENST00000453195, ENST00000455000, ENST00000456093, ENST00000456770, ENST00000463977, ENST00000475230, ENST00000477353, ENST00000477569, ENST00000481596, ENST00000484938, ENST00000486529,
Fusion gene scores	* DoF score	4 X 4 X 3=48	5 X 5 X 5=125
	# samples	4	8
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/125*10)=-0.643856189774725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HCG17 [Title/Abstract] AND TRIM26 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HCG17(30293786)-TRIM26(30172542), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TRIM26	GO:0045087	innate immune response	18248090
Tgene	TRIM26	GO:0046597	negative regulation of viral entry into host cell	18248090
Tgene	TRIM26	GO:0051091	positive regulation of DNA-binding transcription factor activity	23077300
Tgene	TRIM26	GO:1902187	negative regulation of viral release from host cell	18248090

Fusion gene breakpoints across HCG17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4J5-01A	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-

Top

Fusion Gene ORF analysis for HCG17-TRIM26

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000453558	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-5UTR	ENST00000453558	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-5UTR	ENST00000453558	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
5UTR-intron	ENST00000453558	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-3CDS	ENST00000419861	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-3CDS	ENST00000426984	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-3CDS	ENST00000437311	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-3CDS	ENST00000439480	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-3CDS	ENST00000448760	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-3CDS	ENST00000455160	ENST00000437089	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000419861	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000419861	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000426984	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000426984	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000437311	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000437311	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000439480	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000439480	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000448760	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000448760	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000455160	ENST00000454678	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-5UTR	ENST00000455160	ENST00000487829	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000419861	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000426984	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000437311	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000439480	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000448760	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000327357	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000383607	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000396558	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000415923	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000422349	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000425523	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000425831	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000427535	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000428486	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000432326	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000433314	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000436219	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000438384	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000438908	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000439094	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000445259	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000447711	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000450392	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000453195	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000455000	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000456093	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000456770	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000463977	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000475230	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000477353	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000477569	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000481596	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000484938	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-
intron-intron	ENST00000455160	ENST00000486529	HCG17	chr6	30293786	-	TRIM26	chr6	30172542	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HCG17-TRIM26

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HCG17-TRIM26

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30293786/:30172542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HCG17-TRIM26

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HCG17-TRIM26

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HCG17-TRIM26

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HCG17-TRIM26

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source