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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HCG18-MAP2K4 (FusionGDB2 ID:35756)

Fusion Gene Summary for HCG18-MAP2K4

Fusion gene summary

Fusion gene information	Fusion gene name: HCG18-MAP2K4
	Fusion gene ID: 35756
		Hgene	Tgene
	Gene symbol	HCG18	MAP2K4
	Gene ID	414778	6416
	Gene name	HLA complex group 17	mitogen-activated protein kinase kinase 4
	Synonyms	HCG18\|LINC00046\|NCRNA00046	JNKK\|JNKK1\|MAPKK4\|MEK4\|MKK4\|PRKMK4\|SAPKK-1\|SAPKK1\|SEK1\|SERK1\|SKK1
	Cytomap	6p22.1	17p12
	Type of gene	ncRNA	protein-coding
	Description	HLA complex group 17 (non-protein coding)long intergenic non-protein coding RNA 46	dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
	Modification date	20200313	20200329
	UniProtAcc	.	P45985
	Ensembl transtripts involved in fusion gene	ENST00000412685, ENST00000426882, ENST00000438412, ENST00000413358, ENST00000416289, ENST00000421520, ENST00000432895, ENST00000443079, ENST00000443909, ENST00000444126, ENST00000449544, ENST00000454129, ENST00000454269, ENST00000458584, ENST00000602290, ENST00000602319, ENST00000602498, ENST00000602516, ENST00000602550, ENST00000602591, ENST00000602698, ENST00000602861,	ENST00000353533, ENST00000415385, ENST00000581941,
Fusion gene scores	* DoF score	4 X 5 X 7=140	8 X 10 X 6=480
	# samples	9	10
	** MAII score	log2(9/140*10)=-0.637429920615292 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HCG18 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAP2K4(11999011)-HCG18(30264014), # samples:2 HCG18(30294131)-MAP2K4(12011107), # samples:1 HCG18(30294130)-MAP2K4(12011106), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across HCG18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAP2K4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0221-02A	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
ChimerDB4	GBM	TCGA-06-0221	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+

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Fusion Gene ORF analysis for HCG18-MAP2K4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000412685	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3CDS	ENST00000412685	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3CDS	ENST00000412685	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3CDS	ENST00000412685	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3CDS	ENST00000426882	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3CDS	ENST00000426882	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3CDS	ENST00000426882	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3CDS	ENST00000426882	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3CDS	ENST00000438412	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3CDS	ENST00000438412	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3CDS	ENST00000438412	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3CDS	ENST00000438412	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3UTR	ENST00000412685	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3UTR	ENST00000412685	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3UTR	ENST00000426882	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3UTR	ENST00000426882	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
5UTR-3UTR	ENST00000438412	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
5UTR-3UTR	ENST00000438412	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000413358	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000413358	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000413358	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000413358	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000416289	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000416289	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000416289	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000416289	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000421520	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000421520	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000421520	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000421520	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000432895	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000432895	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000432895	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000432895	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000443079	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000443079	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000443079	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000443079	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000443909	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000443909	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000443909	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000443909	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000444126	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000444126	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000444126	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000444126	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000449544	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000449544	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000449544	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000449544	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000454129	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000454129	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000454129	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000454129	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000454269	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000454269	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000454269	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000454269	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000458584	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000458584	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000458584	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000458584	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602290	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602290	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602290	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602290	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602319	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602319	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602319	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602319	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602498	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602498	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602498	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602498	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602516	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602516	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602516	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602516	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602550	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602550	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602550	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602550	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602591	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602591	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602591	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602591	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602698	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602698	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602698	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602698	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602861	ENST00000353533	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602861	ENST00000353533	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3CDS	ENST00000602861	ENST00000415385	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3CDS	ENST00000602861	ENST00000415385	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000413358	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000413358	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000416289	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000416289	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000421520	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000421520	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000432895	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000432895	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000443079	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000443079	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000443909	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000443909	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000444126	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000444126	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000449544	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000449544	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000454129	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000454129	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000454269	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000454269	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000458584	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000458584	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602290	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602290	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602319	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602319	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602498	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602498	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602516	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602516	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602550	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602550	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602591	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602591	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602698	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602698	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+
intron-3UTR	ENST00000602861	ENST00000581941	HCG18	chr6	30294131	-	MAP2K4	chr17	12011107	+
intron-3UTR	ENST00000602861	ENST00000581941	HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HCG18-MAP2K4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+	0.000545485	0.99945456
HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+	0.000545485	0.99945456
HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+	0.000545485	0.99945456
HCG18	chr6	30294130	-	MAP2K4	chr17	12011106	+	0.000545485	0.99945456

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HCG18-MAP2K4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11999011/:30264014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MAP2K4 P45985
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269\|PubMed:7716521}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HCG18-MAP2K4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HCG18-MAP2K4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HCG18-MAP2K4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HCG18-MAP2K4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source