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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HDAC11-FBLN2 (FusionGDB2 ID:35800)

Fusion Gene Summary for HDAC11-FBLN2

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC11-FBLN2
Fusion gene ID: 35800
HgeneTgene
Gene symbol

HDAC11

FBLN2

Gene ID

79885

2199

Gene namehistone deacetylase 11fibulin 2
SynonymsHD11-
Cytomap

3p25.1

3p25.1

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 11fibulin-2FIBL-2
Modification date2020031320200313
UniProtAcc.

P98095

Ensembl transtripts involved in fusion geneENST00000295757, ENST00000402259, 
ENST00000402271, ENST00000404040, 
ENST00000404548, ENST00000405025, 
ENST00000433119, ENST00000437379, 
ENST00000522202, ENST00000446613, 
ENST00000495099, 		ENST00000295760, 
ENST00000404922, ENST00000492059, 
ENST00000535798, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 4 X 4=64
# samples 75
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HDAC11 [Title/Abstract] AND FBLN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHDAC11(13525064)-FBLN2(13611814), # samples:3
Anticipated loss of major functional domain due to fusion event.HDAC11-FBLN2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HDAC11-FBLN2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HDAC11-FBLN2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC11

GO:0016575

histone deacetylation

11948178


check buttonFusion gene breakpoints across HDAC11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBLN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5318HDAC11chr3

13525064

+FBLN2chr3

13611814

+
ChimerDB4LGGTCGA-HW-8321HDAC11chr3

13525064

+FBLN2chr3

13611814

+
ChimerDB4OVTCGA-25-1631HDAC11chr3

13525064

+FBLN2chr3

13611814

+
ChimerDB4STADTCGA-RD-A8N9HDAC11chr3

13522894

+FBLN2chr3

13611814

+


Top

Fusion Gene ORF analysis for HDAC11-FBLN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000295757ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000295757ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000295757ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000295757ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000295757ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000295757ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402259ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402259ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402259ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402271ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402271ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402271ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402271ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402271ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000402271ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404040ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404040ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404040ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404040ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404040ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404040ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404548ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404548ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404548ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404548ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404548ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000404548ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000405025ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000405025ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000405025ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000405025ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000405025ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000405025ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000433119ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000433119ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000433119ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000433119ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000433119ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000433119ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000437379ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000437379ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000437379ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000437379ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000437379ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000437379ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000522202ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000522202ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000522202ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000522202ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000522202ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
5CDS-5UTRENST00000522202ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5UTR-3CDSENST00000446613ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5UTR-5UTRENST00000446613ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5UTR-5UTRENST00000446613ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
5UTR-5UTRENST00000446613ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+
Frame-shiftENST00000295757ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000402271ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000404040ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000404548ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000405025ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000433119ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000437379ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
Frame-shiftENST00000522202ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
In-frameENST00000295757ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000402259ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000402271ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000404040ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000404548ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000405025ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000433119ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000437379ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
In-frameENST00000522202ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
intron-3CDSENST00000402259ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-3CDSENST00000446613ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-3CDSENST00000495099ENST00000535798HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-3CDSENST00000495099ENST00000535798HDAC11chr3

13522894

+FBLN2chr3

13611814

+
intron-5UTRENST00000402259ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000402259ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000402259ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000446613ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000446613ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000446613ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000495099ENST00000295760HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000495099ENST00000295760HDAC11chr3

13522894

+FBLN2chr3

13611814

+
intron-5UTRENST00000495099ENST00000404922HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000495099ENST00000404922HDAC11chr3

13522894

+FBLN2chr3

13611814

+
intron-5UTRENST00000495099ENST00000492059HDAC11chr3

13525064

+FBLN2chr3

13611814

+
intron-5UTRENST00000495099ENST00000492059HDAC11chr3

13522894

+FBLN2chr3

13611814

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HDAC11-FBLN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HDAC11chr313522894+FBLN2chr313611814+0.0225579370.977442
HDAC11chr313525064+FBLN2chr313611814+3.51E-050.99996495
HDAC11chr313522894+FBLN2chr313611814+0.0225579370.977442
HDAC11chr313525064+FBLN2chr313611814+3.51E-050.99996495

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for HDAC11-FBLN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:13525064/chr3:13611814)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBLN2

P98095

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). {ECO:0000269|PubMed:17255108}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBLN2chr3:13522894chr3:13611814ENST000002957600171025_106901185.0DomainEGF-like 10%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017445_48001185.0DomainAnaphylatoxin-like 1
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017488_51901185.0DomainAnaphylatoxin-like 2
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017521_55301185.0DomainAnaphylatoxin-like 3
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017604_64501185.0DomainEGF-like 1%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017679_71801185.0DomainEGF-like 2
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017719_76301185.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017764_80901185.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017810_85701185.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017858_90001185.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017901_94201185.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017943_98101185.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017982_102401185.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST000004049220181025_106901232.0DomainEGF-like 10%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018445_48001232.0DomainAnaphylatoxin-like 1
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018488_51901232.0DomainAnaphylatoxin-like 2
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018521_55301232.0DomainAnaphylatoxin-like 3
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018604_64501232.0DomainEGF-like 1%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018679_71801232.0DomainEGF-like 2
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018719_76301232.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018764_80901232.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018810_85701232.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018858_90001232.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018901_94201232.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018943_98101232.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018982_102401232.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST000004920590181025_106901232.0DomainEGF-like 10%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018445_48001232.0DomainAnaphylatoxin-like 1
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018488_51901232.0DomainAnaphylatoxin-like 2
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018521_55301232.0DomainAnaphylatoxin-like 3
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018604_64501232.0DomainEGF-like 1%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018679_71801232.0DomainEGF-like 2
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018719_76301232.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018764_80901232.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018810_85701232.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018858_90001232.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018901_94201232.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018943_98101232.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018982_102401232.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN2chr3:13522894chr3:13611814ENST000002957600171070_118401185.0RegionNote=Domain III
TgeneFBLN2chr3:13522894chr3:13611814ENST00000295760017178_44401185.0RegionNote=Subdomain NB (Cys-free)
TgeneFBLN2chr3:13522894chr3:13611814ENST0000029576001728_17701185.0RegionNote=Subdomain NA (Cys-rich)
TgeneFBLN2chr3:13522894chr3:13611814ENST0000029576001728_44401185.0RegionNote=N
TgeneFBLN2chr3:13522894chr3:13611814ENST000004049220181070_118401232.0RegionNote=Domain III
TgeneFBLN2chr3:13522894chr3:13611814ENST00000404922018178_44401232.0RegionNote=Subdomain NB (Cys-free)
TgeneFBLN2chr3:13522894chr3:13611814ENST0000040492201828_17701232.0RegionNote=Subdomain NA (Cys-rich)
TgeneFBLN2chr3:13522894chr3:13611814ENST0000040492201828_44401232.0RegionNote=N
TgeneFBLN2chr3:13522894chr3:13611814ENST000004920590181070_118401232.0RegionNote=Domain III
TgeneFBLN2chr3:13522894chr3:13611814ENST00000492059018178_44401232.0RegionNote=Subdomain NB (Cys-free)
TgeneFBLN2chr3:13522894chr3:13611814ENST0000049205901828_17701232.0RegionNote=Subdomain NA (Cys-rich)
TgeneFBLN2chr3:13522894chr3:13611814ENST0000049205901828_44401232.0RegionNote=N

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDAC11chr3:13522894chr3:13611814ENST00000295757+21014_32650348.0RegionNote=Histone deacetylase
HgeneHDAC11chr3:13522894chr3:13611814ENST00000522202+21014_32622297.0RegionNote=Histone deacetylase


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Fusion Gene Sequence for HDAC11-FBLN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HDAC11-FBLN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HDAC11-FBLN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HDAC11-FBLN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource