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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HDAC1-SERINC2 (FusionGDB2 ID:35814)

Fusion Gene Summary for HDAC1-SERINC2

Fusion gene summary

Fusion gene information	Fusion gene name: HDAC1-SERINC2
	Fusion gene ID: 35814
		Hgene	Tgene
	Gene symbol	HDAC1	SERINC2
	Gene ID	3065	347735
	Gene name	histone deacetylase 1	serine incorporator 2
	Synonyms	GON-10\|HD1\|KDAC1\|RPD3\|RPD3L1	FKSG84\|PRO0899\|TDE2\|TDE2L
	Cytomap	1p35.2-p35.1	1p35.2
	Type of gene	protein-coding	protein-coding
	Description	histone deacetylase 1reduced potassium dependency, yeast homolog-like 1	serine incorporator 2tumor differentially expressed protein 2
	Modification date	20200327	20200320
	UniProtAcc	Q13547	.
	Ensembl transtripts involved in fusion gene	ENST00000373548, ENST00000373541, ENST00000490081,	ENST00000373709, ENST00000491976, ENST00000536384, ENST00000373710, ENST00000536859,
Fusion gene scores	* DoF score	13 X 9 X 9=1053	26 X 8 X 13=2704
	# samples	17	27
	** MAII score	log2(17/1053*10)=-2.63089878488802 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/2704*10)=-3.32406383923135 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HDAC1 [Title/Abstract] AND SERINC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HDAC1(32768334)-SERINC2(31883232), # samples:3
Anticipated loss of major functional domain due to fusion event.	HDAC1-SERINC2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. HDAC1-SERINC2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. HDAC1-SERINC2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HDAC1	GO:0000122	negative regulation of transcription by RNA polymerase II	18854353
Hgene	HDAC1	GO:0006476	protein deacetylation	17172643\|23629966
Hgene	HDAC1	GO:0045893	positive regulation of transcription, DNA-templated	16762839
Hgene	HDAC1	GO:0045944	positive regulation of transcription by RNA polymerase II	16762839
Hgene	HDAC1	GO:0060766	negative regulation of androgen receptor signaling pathway	15919722
Hgene	HDAC1	GO:0070932	histone H3 deacetylation	12590135
Hgene	HDAC1	GO:0070933	histone H4 deacetylation	12590135

Fusion gene breakpoints across HDAC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SERINC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-27-2519-01A	HDAC1	chr1	32768334	-	SERINC2	chr1	31883232	+
ChimerDB4	GBM	TCGA-27-2519-01A	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+

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Fusion Gene ORF analysis for HDAC1-SERINC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000373548	ENST00000373709	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5CDS-intron	ENST00000373548	ENST00000491976	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5CDS-intron	ENST00000373548	ENST00000536384	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5UTR-3CDS	ENST00000373541	ENST00000373710	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5UTR-3CDS	ENST00000373541	ENST00000536859	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5UTR-intron	ENST00000373541	ENST00000373709	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5UTR-intron	ENST00000373541	ENST00000491976	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
5UTR-intron	ENST00000373541	ENST00000536384	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
Frame-shift	ENST00000373548	ENST00000536859	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
In-frame	ENST00000373548	ENST00000373710	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
intron-3CDS	ENST00000490081	ENST00000373710	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
intron-3CDS	ENST00000490081	ENST00000536859	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
intron-intron	ENST00000490081	ENST00000373709	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
intron-intron	ENST00000490081	ENST00000491976	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+
intron-intron	ENST00000490081	ENST00000536384	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000373548

HDAC1

chr1

32768334

ENST00000373710

SERINC2

chr1

31883232

2104

246

1625

513

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373548	ENST00000373710	HDAC1	chr1	32768334	+	SERINC2	chr1	31883232	+	0.06701578	0.9329842

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Fusion Genomic Features for HDAC1-SERINC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HDAC1	chr1	32768334	+	SERINC2	chr1	31883231	+	0.000801722	0.99919826
HDAC1	chr1	32768334	+	SERINC2	chr1	31883231	+	0.000801722	0.99919826

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HDAC1-SERINC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:32768334/chr1:31883232)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HDAC1 Q13547	.
FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. {ECO:0000269\|PubMed:12837748, ECO:0000269\|PubMed:16478997, ECO:0000269\|PubMed:17000776, ECO:0000269\|PubMed:17704056, ECO:0000269\|PubMed:17996965, ECO:0000269\|PubMed:19081374, ECO:0000269\|PubMed:19343227}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

131_150

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

160_182

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

202_224

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

239_256

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

268_290

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

317_339

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

385_407

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

40_57

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

422_444

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

5_27

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373709

96_118

456.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

131_150

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

160_182

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

202_224

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

239_256

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

268_290

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

317_339

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

385_407

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

40_57

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

422_444

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

5_27

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000373710

96_118

465.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

131_150

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

160_182

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

202_224

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

239_256

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

268_290

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

317_339

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

385_407

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

40_57

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

422_444

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

5_27

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536384

96_118

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

131_150

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

160_182

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

202_224

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

239_256

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

268_290

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

317_339

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

385_407

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

40_57

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

422_444

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

5_27

460.0

Transmembrane

Helical

Tgene

SERINC2

chr1:32768334

chr1:31883232

ENST00000536859

96_118

460.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HDAC1

chr1:32768334

chr1:31883232

ENST00000373548

9_321

483.0

Region

Note=Histone deacetylase

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Fusion Gene Sequence for HDAC1-SERINC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>35814_35814_1_HDAC1-SERINC2_HDAC1_chr1_32768334_ENST00000373548_SERINC2_chr1_31883232_ENST00000373710_length(transcript)=2104nt_BP=246nt
CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG
CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCT
CACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATATGAGAAGCATGAGGCTGAGAGAG
GAGGAGTCACCCGGACCCAGCCACACAGCGTCCTGCCTCTGCGGCTCTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAAC
TCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGGTGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAG
CTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCACCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTAC
CGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCTTTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCC
CGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCCTGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCC
TTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCTTCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCC
TGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTGCCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTG
CTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGCCCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTC
ACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCCAGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATC
ACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCCCTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAAC
GAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGGATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACC
CTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCCTGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAG
CAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACGAGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGC
CTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGTACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCC
GTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACCTGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTC
AGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCTGGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACA
CCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACCTGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCG
AGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCACACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATA
CTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGGGAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGG
GCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGGGACCCTGCCCACTTCCTGGACTTCGTGCCTTACTGAGTCTCTAA

>35814_35814_1_HDAC1-SERINC2_HDAC1_chr1_32768334_ENST00000373548_SERINC2_chr1_31883232_ENST00000373710_length(amino acids)=513AA_BP=54
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYMRSMRLREEESPGPSHTASCLCGSAPCILCSCCPAS
RNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSR
DPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLF
YLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQL
GNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HDAC1-SERINC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HDAC1-SERINC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HDAC1-SERINC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source