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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HDAC1-ZBTB8B (FusionGDB2 ID:35817)

Fusion Gene Summary for HDAC1-ZBTB8B

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC1-ZBTB8B
Fusion gene ID: 35817
HgeneTgene
Gene symbol

HDAC1

ZBTB8B

Gene ID

3065

728116

Gene namehistone deacetylase 1zinc finger and BTB domain containing 8B
SynonymsGON-10|HD1|KDAC1|RPD3|RPD3L1ZNF916B
Cytomap

1p35.2-p35.1

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 1reduced potassium dependency, yeast homolog-like 1zinc finger and BTB domain-containing protein 8Bputative zinc finger and BTB domain-containing protein 8B
Modification date2020032720200313
UniProtAcc

Q13547

.
Ensembl transtripts involved in fusion geneENST00000373548, ENST00000373541, 
ENST00000490081, 		ENST00000609129, 
Fusion gene scores* DoF score13 X 9 X 9=10532 X 4 X 3=24
# samples 174
** MAII scorelog2(17/1053*10)=-2.63089878488802
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HDAC1 [Title/Abstract] AND ZBTB8B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHDAC1(32782383)-ZBTB8B(32946492), # samples:1
HDAC1(32757819)-ZBTB8B(32946491), # samples:1
HDAC1(32757819)-ZBTB8B(32946492), # samples:1
HDAC1(32757819)-ZBTB8B(32936185), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC1

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneHDAC1

GO:0006476

protein deacetylation

17172643|23629966

HgeneHDAC1

GO:0045893

positive regulation of transcription, DNA-templated

16762839

HgeneHDAC1

GO:0045944

positive regulation of transcription by RNA polymerase II

16762839

HgeneHDAC1

GO:0060766

negative regulation of androgen receptor signaling pathway

15919722

HgeneHDAC1

GO:0070932

histone H3 deacetylation

12590135

HgeneHDAC1

GO:0070933

histone H4 deacetylation

12590135


check buttonFusion gene breakpoints across HDAC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZBTB8B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1Y0-01AHDAC1chr1

32782383

+ZBTB8Bchr1

32946492

+
ChimerDB4STADTCGA-D7-A4YT-01AHDAC1chr1

32757819

+ZBTB8Bchr1

32936185

+
ChimerDB4STADTCGA-D7-A4YT-01AHDAC1chr1

32757819

+ZBTB8Bchr1

32946492

+
ChimerDB4STADTCGA-D7-A4YTHDAC1chr1

32757819

+ZBTB8Bchr1

32946491

+


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Fusion Gene ORF analysis for HDAC1-ZBTB8B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373548ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32936185

+
5UTR-3CDSENST00000373541ENST00000609129HDAC1chr1

32782383

+ZBTB8Bchr1

32946492

+
In-frameENST00000373548ENST00000609129HDAC1chr1

32782383

+ZBTB8Bchr1

32946492

+
In-frameENST00000373548ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32946492

+
In-frameENST00000373548ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32946491

+
intron-3CDSENST00000373541ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32946492

+
intron-3CDSENST00000373541ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32946491

+
intron-3CDSENST00000490081ENST00000609129HDAC1chr1

32782383

+ZBTB8Bchr1

32946492

+
intron-3CDSENST00000490081ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32946492

+
intron-3CDSENST00000490081ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32946491

+
intron-5UTRENST00000373541ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32936185

+
intron-5UTRENST00000490081ENST00000609129HDAC1chr1

32757819

+ZBTB8Bchr1

32936185

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373548HDAC1chr132782383+ENST00000609129ZBTB8Bchr132946492+1212936484860258
ENST00000373548HDAC1chr132757819+ENST00000609129ZBTB8Bchr132946491+1189813384629181
ENST00000373548HDAC1chr132757819+ENST00000609129ZBTB8Bchr132946492+1189813384629181

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373548ENST00000609129HDAC1chr132782383+ZBTB8Bchr132946492+0.0007239890.999276
ENST00000373548ENST00000609129HDAC1chr132757819+ZBTB8Bchr132946491+0.002829550.9971705
ENST00000373548ENST00000609129HDAC1chr132757819+ZBTB8Bchr132946492+0.002829550.9971705

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Fusion Genomic Features for HDAC1-ZBTB8B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HDAC1chr132782383+ZBTB8Bchr132946491+6.81E-060.9999932
HDAC1chr132757819+ZBTB8Bchr132946491+2.61E-081
HDAC1chr132757819+ZBTB8Bchr132946491+2.61E-081
HDAC1chr132757819+ZBTB8Bchr132936184+1.97E-081
HDAC1chr132782383+ZBTB8Bchr132946491+6.81E-060.9999932
HDAC1chr132757819+ZBTB8Bchr132946491+2.61E-081
HDAC1chr132757819+ZBTB8Bchr132946491+2.61E-081
HDAC1chr132757819+ZBTB8Bchr132936184+1.97E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HDAC1-ZBTB8B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:32782383/chr1:32946492)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDAC1

Q13547

.
FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. {ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19081374, ECO:0000269|PubMed:19343227}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZBTB8Bchr1:32757819chr1:32946491ENST0000060912914341_363330496.0Zinc fingerC2H2-type 1
TgeneZBTB8Bchr1:32757819chr1:32946491ENST0000060912914369_392330496.0Zinc fingerC2H2-type 2
TgeneZBTB8Bchr1:32757819chr1:32946492ENST0000060912914341_363330496.0Zinc fingerC2H2-type 1
TgeneZBTB8Bchr1:32757819chr1:32946492ENST0000060912914369_392330496.0Zinc fingerC2H2-type 2
TgeneZBTB8Bchr1:32782383chr1:32946492ENST0000060912914341_363330496.0Zinc fingerC2H2-type 1
TgeneZBTB8Bchr1:32782383chr1:32946492ENST0000060912914369_392330496.0Zinc fingerC2H2-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDAC1chr1:32757819chr1:32946491ENST00000373548+1149_32116483.0RegionNote=Histone deacetylase
HgeneHDAC1chr1:32757819chr1:32946492ENST00000373548+1149_32116483.0RegionNote=Histone deacetylase
HgeneHDAC1chr1:32782383chr1:32946492ENST00000373548+3149_32193483.0RegionNote=Histone deacetylase
TgeneZBTB8Bchr1:32757819chr1:32946491ENST0000060912914132_153330496.0Compositional biasNote=Poly-Ala
TgeneZBTB8Bchr1:32757819chr1:32946492ENST0000060912914132_153330496.0Compositional biasNote=Poly-Ala
TgeneZBTB8Bchr1:32782383chr1:32946492ENST0000060912914132_153330496.0Compositional biasNote=Poly-Ala
TgeneZBTB8Bchr1:32757819chr1:32946491ENST000006091291424_92330496.0DomainBTB
TgeneZBTB8Bchr1:32757819chr1:32946492ENST000006091291424_92330496.0DomainBTB
TgeneZBTB8Bchr1:32782383chr1:32946492ENST000006091291424_92330496.0DomainBTB


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Fusion Gene Sequence for HDAC1-ZBTB8B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35817_35817_1_HDAC1-ZBTB8B_HDAC1_chr1_32757819_ENST00000373548_ZBTB8B_chr1_32946491_ENST00000609129_length(transcript)=11898nt_BP=133nt
CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG
CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGTGATGTGCTGGTGGTCCCCATCAAGCTCCACAAGTGTCCTTTCTGC
CCTTACACTGCCAAACAGAAGGGCATCCTCAAGCGGCACATCCGTTCACACACAGGCGAGCGGCCCTACCCCTGTGAGACCTGCGGCAAG
AGGTTCACTCGACAAGAGCACCTGCGGAGCCACGCACTGAGTGTCCACAGATCCAACCGTCCAATCATCTGCAAGGGCTGCAGGAGAACA
TTCACGAGTCACCTGTCCCAGGGGCTGCGGCGCTTCGGGCTGTGTGACAGCTGCACCTGCGTTACAGACACACCCGATGATGATGATGAT
TTGATGCCCATCAACCTTAGCTTGGTGGAGGCTTCATCTGAAAGCCAAGAAAAGAGCGACACAGACAATGACTGGCCAATCTATGTGGAG
TCGGGTGAGGAAAATGACCCTGCTGGAGATGATTCTGATGACAAACCACAAATTCAGCCTAACTTATCAGACCGAGAGACACTTACGTAG
CAATAAATTGGTGGGGAAGAGGAGGTTTTAAAACTTGTTAGTGCTCGTTCTGTTGTTGAAAGATACCATTTGTCCAATTTTGTGGAACCC
TGAGAGGAACATTTTTTCACTGTTATTATATGTGCATTTTTATTAGACTATCTGATAGAGGTTGGATTTTGTGACTCAAAGGACAGATAA
CCTTTTTGTGTGGTGCCCTTGGTTTCTGAGGGCTTTGCTGGCCACTCCTTAATTCTGAGTGAGTCAAAGCAGGCCCTGAGGTCTCCTGTT
TTTCTTGCTGTGTGTCCAAACTCTGGTTAGGAGAAAGATAAGAAAATCTCCAGGCTTGTTTTTATATTGATTCAGTCCTCTGCATTCCTT
TGTTATCATCCTCTTTCTCTAAAAACCATTAAGTTTTGGGATCAAGTTTACCTTTGCCAAGCCTTTCCTAATGAATTCCACATTAAATTT
TCTGGCAAAGTATTAAAGAGAAACCTTCATTGATATAAAGCAGGCAGGGCGGTCTGGCTACATGATCATAAAAGGTACTCCCTAAATCTA
GAACAATTTTAAAGGCTTGGAATACTTATGGGCAGACGAACATGGGAATGATCTGAAAGGCTCATTATGGCATCCTGACTTGCCCAGTTG
AATTAAATTTTAAGTTAGCCCTGAGAAGGGAGGCTATGACCCCAGGTCTGGATGGTTTCCCTGTCTGGTTTGGCATTTGACGATTCTACA
CATACAACCTGTTCTGTTATCATAAAACAACTCATTTGGGCAAAACTCAAAATGCTCCCCTACTTTTTCCAGCAATTTCCAAAAGCTGGA
GCTGTGTAACTTGGAAATGTAGCTGCCTCTGGCATTCTTTTACTTAGTTTATGCTGATGTAGGGCAGGTGAGCCCAAAAATTGGGGCTTA
GCCCAGAGGAGTTCTTGGCTTCACCCAGGAAAGAATTCAAGGGCAAGCCAGTGGTGTTAGACAGCAGCTTGTATTGAAGCAGCAGTGCCC
AACAGCAGCTAAGGGGCCGCTCCTCGTGGAGCAGGGCTACACCATAGGCAGTGTGCCCAGAGTAGTAGCTCAGAGGCAGGTCGGCACTTA
TATTTATACCCACTTTTAGTTACATGCAAATTAAGGGGCAGATTATGCAGCAATATTTAGGAAAATGGTGGTAACTTCCAAGCCGCTGGG
TGGTTGCCATGATAAGGGGCAGTGACTTCCAGGTGTTGCCATGGCAATGGTAATTGACATGGCACAGTGATAAGTGTTTCTTATGGAAAT
CTGCTTCCTGCACCACCCTCCCACCACCGCCCTGTTTTAGCTAGTCCTCAATTTGGTCCATGTCCGAGTCCGGCCTTTGGAGTTGAGTCC
TGCCTTCTACCTCCTTGCCTAGAACTTTAATTGGAGGGAAAGTATAAGCCCATAATGCCAAGTAACATTTCTAAAATGTTCATCTTTTAA
AAGATCTTCATGAGGGAAAGGGAAGGTTAGTAGCAGAACAGGTTTTTAAAAGCAGTCTACCTTTCGCCCACTTTCCAGCCACACAATTAT
TGTAACAAAAGAGGCTGAACTCTTTAAAGGGCTAAAGGGCAGGCAGTGTTAGGAATTCGGAATGTAATTGAAGGCAATTTCCATAATTTT
GTCTTATGTTAAAATATCCAAAATGGATTTTAAAAGAAATCTTCTTGTCTTCCTTTAAGTGTAGTTGTCTTTCAAAAGGTGGTAAAAGTC
ACTTTTATTTCTACCTCTTGAACAACAAAAAAGTCAAAAACATTATAAATTGGCTTGTAAATGTTAGCCAAAGCATTAGACAGGTGTTTA
AGTCGTACTTCTCAATAGTAGTTAAAACTGGAACAGTGCAACTCAAACTCTGGCCCACAGAGAGGCCCTGTTCTGTAAACTGTTTTCTAC
CAGTCTGCTACAAGGAAAGTCAGAAATTAAGAATACACATATAGAAATGTTGATAACACTTTGACATTGCTGTGACTCATGGCTTTGTCT
TCTTGAGTGAGGTATGGACCAGTTCAGTTCTGGTCAGCTAGAGGGCCACATGGTGCAGAGGTTGGATACCAGCCTGTACAGCAGGACCAC
GTATTGGTCTGCAGTAGAATGGAAAATTTAAAACTTCTCTTATCACAGGTAGTTCGATAAATATCATTCTTGGCTGTGTGCGGTGGCTCA
CGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGATGGAACACTTGAGGTCAGGAGTTCGATACCAGCCTGACCAACATGGCGAAACC
CCGTCTCTAGCAAAAATACAAAAATTAGTCAGGAGTGGTGGCATGTGCCTGTAATCCCAGCTACTCAGGAGGCTGTGGCGAGAGGAACAC
TTGAGCCTGGAAAAGGTTGCAGTGAGCTGGAATCGTGCCACTCCACTCCAGCCTGGGCAACAGTGTGAGACCTTGTCTCAAAAAAATAAT
AATAAAATAAATAAATAAAAGAAAAATATTCTAGATCAAGAGTTACTCATTGAAAATTATCAGGGACCAGAGATATTTGTCTTATCTGAA
ATAAAAATACTAGCTGTGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCG
GGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAAT
TCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCTGTGAGCCGACATCACACCACTGCACTCCAG
CCTGGGCAACAAGAGCGAAACTGTCTCCAAAAATGTATACATATATTTGCTGTTATTTTAAAAGAGGGATCTCAGCAAAAAGGAAACCTA
AATGGATGTGTAGAAGATTTACTTGGCCAGGAACAGTGTTTGATATTTTTGCTTTCTCTGTTTAAATTATCTCTGATGTTTTAATGACTT
TTCTACCTCATAGTTCAGCCTCTTTGCCTGCTTTCTCCAGTGGAGCTATGATCCTCTTCAGTGATTCCGTGACCTCTTCATATCCCTGGG
TAAAACATTTTACATTAGAGATTTCACTGTAGGACAGTGATTCTCAGTTGGGGGTGATTTCGTGCCTTGCAGGTGGCTACTGGCATCTAG
TGGGTAGAGGCCAGGGAAGCTGCCAAACATCCTGAAATGCACAGGACAGTCCCCACAACAATGAATTCTCCAATTCAAAATGTCAGTAAT
ACCAATGTTGAGAAACTCTGCTGTAAGATAAAGTAGGATTTTTTAAAGGATCTTTAATGAGTGGACTTAATTTTGTGTTCTATTTTAAGC
TACCTTTTACCTGCATAATATTTATTTATTTTTAATTTTATTTTATGTATTTATTTATTTATTTTGAGATGGAGTTTCATCTTTGTCACC
CAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTTCTGTCTCAGCCTCTTGAGTAGT
TGGGATTATAGGCACGCGCCACCACGCCTGGCCAATTTTTGTATTTTTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGA
ACTCCTGACCTCAAGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCTGACCTTCATAAT
ATTTAGTAGCCCCTTATACTCTCGCAAATTTTAGAAAATAGTGGATTAGTAAAATGAAGCGCTGAGGCCAGATGGTTCATAGCTTGCCCA
AGATCTGATTTAGGTTTATAATGTGGAAACTTAGAAAATTCTGACTCATTCATACACCCAGAATCGTTACTAGGTTCTGATCATTTTGTT
AATTTTTAAAGTAGCAGAATCACTGGGAAGAAAACAGAATGTGACACCTAATGTTTAAATGATTCTCTTTCTTTCGTAATATCTCAGATT
GTTGCATTTCTGGTGGACTATTTGGAGTTTGTGTATAGGCACTGGCAATAACTGGATCACTGAGTTCTATCACTTTTAAAGGAGATACTT
CCTCTGTCTAGACTATCAGATCATAAATTGGTCCCCTTTAGGTGGTCAGTATTTATAATCACAGTGTCTTTGAGGTTTAATTTGTGGGGT
TGGTGGTATTTTTATACTAAGTAAATTTACAGTTGAGCCCAACACAGACCGTTAGTGGTTTAGTTTCTATTCTGGCACATTCCACCCAAG
TTCACAAAGGGATATTTTCGTCTCATATTAGATGTATTGCATGAATGGGAACAGGACTCTTACTTGTAATGGAATTCCAAAATGGCATTC
TTGGGAAGTTATTTCTCTTGGGGGATGAGGACCCCCTTCTCAAAAGTTGAGAAGGAATGTAAATAGGGCCTTACCTATAATAATTAAGAA
ATGACATAGTGCATCATGATTCTGATCATTTGGCAGAAAGATGCCGTTCTGATGTAAATATTTTGGTGGCCACCAGACTTTGAATATTCC
TTAAGGAAGCTGCTGACCTAGTGTTCTGCAACATGTTATGGAATTGAGTATTCTGGTGGTTTGGAATACTGAGATGGGTTTTTTTTGTTA
TTGTTCATTGATGTCGTGACAAACCCCAGGGAGAGAAAGGCAACAGGTAGGGCTGCATGCACTGATTCTGGGAGCCGTAGGAAAGAGTGG
AGTGGCCTTTGGTTAACTGAACTCAGACTGTTTTATTTGGAACTCTAGATTTTTCTTGTGTGTGTCCCTTGTGCATTAAGAGAATGATCT
CTGTGAAGTCTAGTGTAATGGGGTAGGGAGGGGCAAAGGGTTGGGATGGGTGAGAAGTTCCTATTATGCTCTGTTTTGAGCATTCCCACT
GTGCTTCCTGTTGTTGCTGGTCTCTTGTAGCTTGCCTTGTGTTTTCATGTGATCACACTATCTTCTAACCTGATAAAGGGACACTTTATT
CAGGTGCATATGATGGGCACTGTTTTCATTGATTTCTGTTGCTTTTGTAGTTCTCTCCACTCAACAGTACTGTGTTCCACAAACCTTTCA
TTGTAGTGCTGGAAATTTGAATTCTTTTCTTCAAATGATGTTTCTGTAGAGAAAAACGAAAAGTGTTTTGGGGTCAGAGTAGTTTGGTTG
GTTCCTAAACATGTCCTAGTTTTTGTTGTTGTTGTTGTTTTTCTTTTCTTTTTTTTTCTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTG
GAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACT
ACAGGCACCCGCCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATAGTCTCAATATCCT
GACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCGCCCGGCCTAAATATATCCTAGTTTTAA
AAGGTGACAGTAACTCACATGACTGCATGATCGGATGACATGGAAACTTCATAACTGAAGGAGAACATTTAGCATCCGTCTTGACCCTCC
AGGTAGATTATTTTACTACTGCCAATTCTTCATTGACAATTGTGGTTTTAGGGGGGGCAATTTTTATATCCATCATTTGATTTCTGGACC
TTTGTCAGTTAATCAGTGGAGGTTAGGGCAGGGATTATGTGCTTTGATGAGGAAGGTTTAGTAGTAACAAGCTTGGGGATTTTGAAGGAA
GGCATCAATTTCATATACAGGTCTTGGTGACATGTAATGGATATGGATTATCTGTCATGCATACAGTGAAGGGTATGGTCAGGATTTTTT
TGGAAGTAGAAAAACATACCAAACAGTTTCACATCTTTTACCATCCATAGCCCCTGAGGAGCATCTACTGCCATCAGAAAAACATGCAAA
TAATACTGCAGTGCCCTCCAAGGGTCTTAGGCCCAACTGAAGGTTTAGAAACATTCAAATTTATAAACTGCCACACTTGGCATCAGATTC
ACTTAAAAGGATATAGAATGGGAAGCACTGCTTACTAGCAAGGCAGAACCAGTTGCTCTTCTCTGAAAGTCTCTGCAGCTGTCTGTGTGG
CATAGTGCAGGTGCAAGGAGACAGATCTACATGGGGCAAGTATGGAAGCTTCCCCGGCTTAAGAGCCCCTTGTCCCACAGGAACAAGTAT
CTCTTATAACAGCTTCATAGACATGGCCTCCAGTGTCCCTATAAAAGACATGCCTGTTCCAAGCGTCACTGTACTTAGGGATGCCCAGAG
CTGAGGCTTCCTATCAGGCATTTATAGTTCTCCCAGTCCAGATGCAGTTTACCAATTGGGCATCATGTCTACCATATGTAACATTGCCTA
GCAGTTGACATATGAATTTTTATTAGGTTGCCAGGGGAACAGAGCTAGAAAGTTAACAAAGGTAAAATTCTCATGCAGAAGGGAAAGAGG
CTTTGTTAATACTTTGCCAAACACTATGCTAAGCAATTGCATAACAGATATTACACCTAATTCCTATAGAATATAGCCAGAGGAATTTCC
TAGTAAAATATAACCCACCCTAACTCATTTTTCCTTTCTTGAATAGTGTTGTTGGTGCTTAGTTGCTTGTGATTAATAGACAGTTTGCAA
ATTTTGGTAAGGTGTGTGTAAGAGTTGGCTTAACAGTCAAAATGATCCTAGCCAAAATATCATGTATCCTTTGGTGTCACTCATAATAGG
TGAGTATAGTATGTCGTACTGTAGGGACATTATTGAATGGACATGTCTGAGTATTCCATCAGTCATATTTTGATGGGAGCCTTTGGCCAT
CTGGCAAACACCAAACACAGGCTCTTGGTAACCGTGCCTTTTTTTTTTTTTTTTTTTTTTTAAAGATGGAGTTTCACTCTTGTTGCCAGG
CTGGAGTGCAGTGGTGCAATCTCGGCTCACCACAACCTCCGCCTCCTGGATTGAAGCGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGG
ATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGATCTCGGCCTG
ACCTCAGGCAATCCGCCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACTGCGTCCGGCCTGCTCTTGGAAACCGTGCCTCTT
ATTCCTGTGTCATGTGGTGCTACTCTTGCCTGCTTCTGTTGCTCCCAGCAGATCAATGAGTGAAGATGGCTGGTTACTCATTCAGTAGTT
ATCAAACAATTATTTATGGAGTCTTTACTGTATGTCAAGCACGAAGGGTACTTCAGTGAACCAGCACCATCCCTGCCCTCAAGGATCCTG
CAGTGTGTAATCACAGAGACTGGCAGTTATAACACGGCATGTTGGGTGTGACAACAGGGACAAGCACAGGGTACTCTGAGAACGCGTGGG
TCGGGTACCTAGCCAGTCATAGAGCCTCAGAGACGCTTTCTGTCTAAGCTACTCTTCCTATCCAGTAAACTTCCAGCTTTGGCATACTAT
ATTTATAAGCAGTTTAAACAGTTGCTGAAATTTATTGCCTTTTCTCAAACATGGTGGCTTTGGTCACTAACAGTGTTTAAATTATGTGTT
TTATTCAGTTATGCAAAAATATATACTATACATAGAATATCAGAATGTTGTAGTCTTTAGGAAATATGCATCAGGTTTGTTTTTTTTGTT
TTTTTGACAGACTCTCACTCTGTCGCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACCTCCGTATCCCAGGTTCAAGTGAT
TCCCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGCGTGTGCCACCACGCCCAGCTAATTTTTTGTATTTTATAAGAGATGGCGTGT
CACCATGTTGACCAGGATGGTCTTGATCTCCTGACCTCGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCA
CTGTGCCTGACTGGGTGGTTTTCTTTTTTAAAAAATAATATGGTTTTCTGGCCGGGAGCAGTGGCTCATGCCTGTAATCCCAGCACTTTG
GGAGGTCAACGGGGGTGGATCACCTGAGGTCAGGAGTTAAAGACCAGCCTGGCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAA
ACAGGAGAATCGCTTGAACTCGGGAGGTAGAGGTTGCAGTGAGCTGAGATAATGCCACTGCACTCCAGCCTGGGCGACGGAGTGAGACTC
CATCTCAAAAAAATAAAAAATAATAATAATATGGTTTTCTTATTTAAAAAATAATATAGTATGTAAATTATTTTTCAAGTAAAAATGAAA
TGACAACAACAGATAACTTCCCATTATGTTGATCCAGTGTACTGTGACAGATGGGGAGGAGCCCCACTGCATCTGGAGTGGGTCTTGGCT
GGCCATGTGAACTAATTAATACCCCAGAAATCAGGATACATGCCAGGCGTCGGGGCTTACGCCTGTAATCCCAGCATTTTGGGAGGCTAA
GGTGGGTGGATCCCTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATATACAAAATTAGCC
TGTAATTCCAGCTACTTGGGAAGCTGAGGAAGGAGAATTGCTTGAGCCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCA
CTTCAGCCTGGGCAACGAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAATCAGGATACATATAGGACAGAACCATT
AAATCAAGAGATTTGAAAGTTAGAAGGGACAGGAGAGATAGTCTAGTCCAACTCCATGTGACAGATGAAATGACGTTTCTAGTTCTCACA
CAGCTGGTTAGGATCAGAAACCAGGTCCTGCCAGGCCAGTCCTGATAATAGACAGACATGTTTGGGCAGGCAGAAAAGACCATTCATAGA
TAACATTTGTTTCCCTGGGTATCCATCAGACCAGAGGCACAGGAGAGGAAAATGCTGTTTTGGCCTCATATGATAAAGTATGCATTGTGT
GATTATGGTCTGCATTCTTGCAATGCTTAGACAGGGAGGGGGAAATCACATTTTGAGCATGGGGGAGTTAATTTCTTTGTCCTGTAATAC
CACACATATCTAAAACATAAACCACCATGGAACACACTCACACTCACATACACACAAAAGGCAAATTAAAATATTTATTGTCCACTTAAT
ATGTGTTCTGTGTTTGATTGTAATGTATTCATTTTACTTATAAAAAATTTCAAAAGTAAAAATATATATATTATTAACTTGAAGTGATTT
TTTCCAACCTCGCTGATTTTTTTCCTTCTTTCTTTTTTGAGACAGAGTTCCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCG
GCCCACTGCAATCTCCGCCTCCAGAGTTCAAAGAGTTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAGGTATGCCACCATGCC
CGGCTAATTTTTGTATTTTTAGAAGAGATGGGGTTTCATTTTGGTCAGGCTGGTCTCGAACTCCTAACCTCAGGTGATACACCCGCCTCA
GCCTTCCAAAGTGCTGAGATTACAGGTGTGAGCCACCATGTCCGGCCTCTAACTGATTTTTGAAATATAAATTGGGTGTGATTCAGGGAA
TGTAACAAGAACAATCTTATTTGAAACAGAAAACCACATATTTTTAAGTCAGCAGCCCACATGATAAGATGGTATTGAGTAAAAATGTAT
TCTTAGGTATTTCTTGACTCAGTGGATTTTAATCAGTCTACTGCAAAAGCTAGTTTTATTTAAAGGGCTGCAATTATATATAAGAATTAT
TAGAAAAACAGATTAGCCACTTAATCTAAAAATACCTAGATGCAGTATTCCTGGTTTTTAATGAAATATTTATCTAGTTTGGGATTAAAA
TTAACTTAGGGCCATCAAAAATGCAAATTATCTTTAATTTGGTTAAATCAACCTGGGAGTAAATGGAAATAATCTCAAGCTAAATTTTTG
TTTTGATTTATATACAGTCAGATTGAAACACCCTAGTTACAAGTTTAGAATAGGAGTGGCCTCAACAAAGGAAAAAGTCCTTTGTTCCTC
TGTTGCTCATTTTGTCCTCGGAAACAAATACAATTTAACTATTTTCTGTACCGTCCCAAATTTGAAGCTGACCTGAATTTGGTACCTATA
AATTTAAAATGGCTAAGGTTAAAATAGTTAAAACAGTTTCTTTAGAATGAGTTGTTAGCTGGGTGTGGTAGTGTACACCTGTAGTCCCAG
CTACTCCAAAGGCTGAGGCAGGAGGATTGCTTGAGCCCAGAAGTTCAAAGCTGCAGTGAACTAGGATCATGTCACCACACTCCAGCGTGG
GCAACAGAATGAGACCCTGTCTCAAAAAAAAAGGTTTTTTTTTAATTGAATGAATGCAATAAGGAATTGAGGATCGTCTCACATTAATGA
GTGAATAACCCTTCATAATTTTAGTTACTGTTTTTCTCAGGGCAATTATTTTATATAAAATTCTAATGGAGAATTTTATGGACAAGATTT
TAGTTAAGGAAAAAAATAACCCCACAAAATAAAGAGAACTATTAGAGCTCTAAACAGAAGAAGCTTCCATCAAACCGTTTTTCCCACTTT
TTTGTCCCACGGTCTTAGGACCAACAATTTAGTAATACGAGACAATTTCTGGCAGACTATCCCAAGCTGGGACATTTTAGATTCTGTGAA
AGAAGACTGACTACTGTCTGATGAATGGGTAATTGATGATGCAATGTATGAAAAAAGTAAGGCAGACAACTCAAAAATCACAGGAAGTGC
AGCCATTCTACGTGCCGAGCTCTACAGTTACACACTGTCCAACAGCTCTCGGAAGAAAAACAGAAACTGACTTTATCTTTGCCTGCCAAG
TTTGCAAATGGATTAGTTCATTACAAAGGCACTTGTCAAAACATATTTATTAAAAAGAGGAGCCAGAGTTGGAAATCATCTTGACCATTA
AAAAAATAGCAACTGATACCTTGTTTAACAAGTAAGACAGTTTCTGCTTTTTGGAATTGAATTGGTTTTTAAGTGGTAATGTACCAGGTC
TGTTTATATAGGTCAGTGTTGCCCAGGTTGTATTGTTTTGCTGTTTTTACTTTTTTATATATAAAGAACTAAAATTACGAGAGAATAAAT

>35817_35817_1_HDAC1-ZBTB8B_HDAC1_chr1_32757819_ENST00000373548_ZBTB8B_chr1_32946491_ENST00000609129_length(amino acids)=181AA_BP=0
MAQTQGTRRKVCYYYDGDVLVVPIKLHKCPFCPYTAKQKGILKRHIRSHTGERPYPCETCGKRFTRQEHLRSHALSVHRSNRPIICKGCR
RTFTSHLSQGLRRFGLCDSCTCVTDTPDDDDDLMPINLSLVEASSESQEKSDTDNDWPIYVESGEENDPAGDDSDDKPQIQPNLSDRETL

--------------------------------------------------------------
>35817_35817_2_HDAC1-ZBTB8B_HDAC1_chr1_32757819_ENST00000373548_ZBTB8B_chr1_32946492_ENST00000609129_length(transcript)=11898nt_BP=133nt
CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG
CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGTGATGTGCTGGTGGTCCCCATCAAGCTCCACAAGTGTCCTTTCTGC
CCTTACACTGCCAAACAGAAGGGCATCCTCAAGCGGCACATCCGTTCACACACAGGCGAGCGGCCCTACCCCTGTGAGACCTGCGGCAAG
AGGTTCACTCGACAAGAGCACCTGCGGAGCCACGCACTGAGTGTCCACAGATCCAACCGTCCAATCATCTGCAAGGGCTGCAGGAGAACA
TTCACGAGTCACCTGTCCCAGGGGCTGCGGCGCTTCGGGCTGTGTGACAGCTGCACCTGCGTTACAGACACACCCGATGATGATGATGAT
TTGATGCCCATCAACCTTAGCTTGGTGGAGGCTTCATCTGAAAGCCAAGAAAAGAGCGACACAGACAATGACTGGCCAATCTATGTGGAG
TCGGGTGAGGAAAATGACCCTGCTGGAGATGATTCTGATGACAAACCACAAATTCAGCCTAACTTATCAGACCGAGAGACACTTACGTAG
CAATAAATTGGTGGGGAAGAGGAGGTTTTAAAACTTGTTAGTGCTCGTTCTGTTGTTGAAAGATACCATTTGTCCAATTTTGTGGAACCC
TGAGAGGAACATTTTTTCACTGTTATTATATGTGCATTTTTATTAGACTATCTGATAGAGGTTGGATTTTGTGACTCAAAGGACAGATAA
CCTTTTTGTGTGGTGCCCTTGGTTTCTGAGGGCTTTGCTGGCCACTCCTTAATTCTGAGTGAGTCAAAGCAGGCCCTGAGGTCTCCTGTT
TTTCTTGCTGTGTGTCCAAACTCTGGTTAGGAGAAAGATAAGAAAATCTCCAGGCTTGTTTTTATATTGATTCAGTCCTCTGCATTCCTT
TGTTATCATCCTCTTTCTCTAAAAACCATTAAGTTTTGGGATCAAGTTTACCTTTGCCAAGCCTTTCCTAATGAATTCCACATTAAATTT
TCTGGCAAAGTATTAAAGAGAAACCTTCATTGATATAAAGCAGGCAGGGCGGTCTGGCTACATGATCATAAAAGGTACTCCCTAAATCTA
GAACAATTTTAAAGGCTTGGAATACTTATGGGCAGACGAACATGGGAATGATCTGAAAGGCTCATTATGGCATCCTGACTTGCCCAGTTG
AATTAAATTTTAAGTTAGCCCTGAGAAGGGAGGCTATGACCCCAGGTCTGGATGGTTTCCCTGTCTGGTTTGGCATTTGACGATTCTACA
CATACAACCTGTTCTGTTATCATAAAACAACTCATTTGGGCAAAACTCAAAATGCTCCCCTACTTTTTCCAGCAATTTCCAAAAGCTGGA
GCTGTGTAACTTGGAAATGTAGCTGCCTCTGGCATTCTTTTACTTAGTTTATGCTGATGTAGGGCAGGTGAGCCCAAAAATTGGGGCTTA
GCCCAGAGGAGTTCTTGGCTTCACCCAGGAAAGAATTCAAGGGCAAGCCAGTGGTGTTAGACAGCAGCTTGTATTGAAGCAGCAGTGCCC
AACAGCAGCTAAGGGGCCGCTCCTCGTGGAGCAGGGCTACACCATAGGCAGTGTGCCCAGAGTAGTAGCTCAGAGGCAGGTCGGCACTTA
TATTTATACCCACTTTTAGTTACATGCAAATTAAGGGGCAGATTATGCAGCAATATTTAGGAAAATGGTGGTAACTTCCAAGCCGCTGGG
TGGTTGCCATGATAAGGGGCAGTGACTTCCAGGTGTTGCCATGGCAATGGTAATTGACATGGCACAGTGATAAGTGTTTCTTATGGAAAT
CTGCTTCCTGCACCACCCTCCCACCACCGCCCTGTTTTAGCTAGTCCTCAATTTGGTCCATGTCCGAGTCCGGCCTTTGGAGTTGAGTCC
TGCCTTCTACCTCCTTGCCTAGAACTTTAATTGGAGGGAAAGTATAAGCCCATAATGCCAAGTAACATTTCTAAAATGTTCATCTTTTAA
AAGATCTTCATGAGGGAAAGGGAAGGTTAGTAGCAGAACAGGTTTTTAAAAGCAGTCTACCTTTCGCCCACTTTCCAGCCACACAATTAT
TGTAACAAAAGAGGCTGAACTCTTTAAAGGGCTAAAGGGCAGGCAGTGTTAGGAATTCGGAATGTAATTGAAGGCAATTTCCATAATTTT
GTCTTATGTTAAAATATCCAAAATGGATTTTAAAAGAAATCTTCTTGTCTTCCTTTAAGTGTAGTTGTCTTTCAAAAGGTGGTAAAAGTC
ACTTTTATTTCTACCTCTTGAACAACAAAAAAGTCAAAAACATTATAAATTGGCTTGTAAATGTTAGCCAAAGCATTAGACAGGTGTTTA
AGTCGTACTTCTCAATAGTAGTTAAAACTGGAACAGTGCAACTCAAACTCTGGCCCACAGAGAGGCCCTGTTCTGTAAACTGTTTTCTAC
CAGTCTGCTACAAGGAAAGTCAGAAATTAAGAATACACATATAGAAATGTTGATAACACTTTGACATTGCTGTGACTCATGGCTTTGTCT
TCTTGAGTGAGGTATGGACCAGTTCAGTTCTGGTCAGCTAGAGGGCCACATGGTGCAGAGGTTGGATACCAGCCTGTACAGCAGGACCAC
GTATTGGTCTGCAGTAGAATGGAAAATTTAAAACTTCTCTTATCACAGGTAGTTCGATAAATATCATTCTTGGCTGTGTGCGGTGGCTCA
CGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGATGGAACACTTGAGGTCAGGAGTTCGATACCAGCCTGACCAACATGGCGAAACC
CCGTCTCTAGCAAAAATACAAAAATTAGTCAGGAGTGGTGGCATGTGCCTGTAATCCCAGCTACTCAGGAGGCTGTGGCGAGAGGAACAC
TTGAGCCTGGAAAAGGTTGCAGTGAGCTGGAATCGTGCCACTCCACTCCAGCCTGGGCAACAGTGTGAGACCTTGTCTCAAAAAAATAAT
AATAAAATAAATAAATAAAAGAAAAATATTCTAGATCAAGAGTTACTCATTGAAAATTATCAGGGACCAGAGATATTTGTCTTATCTGAA
ATAAAAATACTAGCTGTGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCG
GGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAAT
TCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCTGTGAGCCGACATCACACCACTGCACTCCAG
CCTGGGCAACAAGAGCGAAACTGTCTCCAAAAATGTATACATATATTTGCTGTTATTTTAAAAGAGGGATCTCAGCAAAAAGGAAACCTA
AATGGATGTGTAGAAGATTTACTTGGCCAGGAACAGTGTTTGATATTTTTGCTTTCTCTGTTTAAATTATCTCTGATGTTTTAATGACTT
TTCTACCTCATAGTTCAGCCTCTTTGCCTGCTTTCTCCAGTGGAGCTATGATCCTCTTCAGTGATTCCGTGACCTCTTCATATCCCTGGG
TAAAACATTTTACATTAGAGATTTCACTGTAGGACAGTGATTCTCAGTTGGGGGTGATTTCGTGCCTTGCAGGTGGCTACTGGCATCTAG
TGGGTAGAGGCCAGGGAAGCTGCCAAACATCCTGAAATGCACAGGACAGTCCCCACAACAATGAATTCTCCAATTCAAAATGTCAGTAAT
ACCAATGTTGAGAAACTCTGCTGTAAGATAAAGTAGGATTTTTTAAAGGATCTTTAATGAGTGGACTTAATTTTGTGTTCTATTTTAAGC
TACCTTTTACCTGCATAATATTTATTTATTTTTAATTTTATTTTATGTATTTATTTATTTATTTTGAGATGGAGTTTCATCTTTGTCACC
CAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGAGATTCTTCTGTCTCAGCCTCTTGAGTAGT
TGGGATTATAGGCACGCGCCACCACGCCTGGCCAATTTTTGTATTTTTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGA
ACTCCTGACCTCAAGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCTGACCTTCATAAT
ATTTAGTAGCCCCTTATACTCTCGCAAATTTTAGAAAATAGTGGATTAGTAAAATGAAGCGCTGAGGCCAGATGGTTCATAGCTTGCCCA
AGATCTGATTTAGGTTTATAATGTGGAAACTTAGAAAATTCTGACTCATTCATACACCCAGAATCGTTACTAGGTTCTGATCATTTTGTT
AATTTTTAAAGTAGCAGAATCACTGGGAAGAAAACAGAATGTGACACCTAATGTTTAAATGATTCTCTTTCTTTCGTAATATCTCAGATT
GTTGCATTTCTGGTGGACTATTTGGAGTTTGTGTATAGGCACTGGCAATAACTGGATCACTGAGTTCTATCACTTTTAAAGGAGATACTT
CCTCTGTCTAGACTATCAGATCATAAATTGGTCCCCTTTAGGTGGTCAGTATTTATAATCACAGTGTCTTTGAGGTTTAATTTGTGGGGT
TGGTGGTATTTTTATACTAAGTAAATTTACAGTTGAGCCCAACACAGACCGTTAGTGGTTTAGTTTCTATTCTGGCACATTCCACCCAAG
TTCACAAAGGGATATTTTCGTCTCATATTAGATGTATTGCATGAATGGGAACAGGACTCTTACTTGTAATGGAATTCCAAAATGGCATTC
TTGGGAAGTTATTTCTCTTGGGGGATGAGGACCCCCTTCTCAAAAGTTGAGAAGGAATGTAAATAGGGCCTTACCTATAATAATTAAGAA
ATGACATAGTGCATCATGATTCTGATCATTTGGCAGAAAGATGCCGTTCTGATGTAAATATTTTGGTGGCCACCAGACTTTGAATATTCC
TTAAGGAAGCTGCTGACCTAGTGTTCTGCAACATGTTATGGAATTGAGTATTCTGGTGGTTTGGAATACTGAGATGGGTTTTTTTTGTTA
TTGTTCATTGATGTCGTGACAAACCCCAGGGAGAGAAAGGCAACAGGTAGGGCTGCATGCACTGATTCTGGGAGCCGTAGGAAAGAGTGG
AGTGGCCTTTGGTTAACTGAACTCAGACTGTTTTATTTGGAACTCTAGATTTTTCTTGTGTGTGTCCCTTGTGCATTAAGAGAATGATCT
CTGTGAAGTCTAGTGTAATGGGGTAGGGAGGGGCAAAGGGTTGGGATGGGTGAGAAGTTCCTATTATGCTCTGTTTTGAGCATTCCCACT
GTGCTTCCTGTTGTTGCTGGTCTCTTGTAGCTTGCCTTGTGTTTTCATGTGATCACACTATCTTCTAACCTGATAAAGGGACACTTTATT
CAGGTGCATATGATGGGCACTGTTTTCATTGATTTCTGTTGCTTTTGTAGTTCTCTCCACTCAACAGTACTGTGTTCCACAAACCTTTCA
TTGTAGTGCTGGAAATTTGAATTCTTTTCTTCAAATGATGTTTCTGTAGAGAAAAACGAAAAGTGTTTTGGGGTCAGAGTAGTTTGGTTG
GTTCCTAAACATGTCCTAGTTTTTGTTGTTGTTGTTGTTTTTCTTTTCTTTTTTTTTCTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTG
GAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACT
ACAGGCACCCGCCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATAGTCTCAATATCCT
GACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCGCCCGGCCTAAATATATCCTAGTTTTAA
AAGGTGACAGTAACTCACATGACTGCATGATCGGATGACATGGAAACTTCATAACTGAAGGAGAACATTTAGCATCCGTCTTGACCCTCC
AGGTAGATTATTTTACTACTGCCAATTCTTCATTGACAATTGTGGTTTTAGGGGGGGCAATTTTTATATCCATCATTTGATTTCTGGACC
TTTGTCAGTTAATCAGTGGAGGTTAGGGCAGGGATTATGTGCTTTGATGAGGAAGGTTTAGTAGTAACAAGCTTGGGGATTTTGAAGGAA
GGCATCAATTTCATATACAGGTCTTGGTGACATGTAATGGATATGGATTATCTGTCATGCATACAGTGAAGGGTATGGTCAGGATTTTTT
TGGAAGTAGAAAAACATACCAAACAGTTTCACATCTTTTACCATCCATAGCCCCTGAGGAGCATCTACTGCCATCAGAAAAACATGCAAA
TAATACTGCAGTGCCCTCCAAGGGTCTTAGGCCCAACTGAAGGTTTAGAAACATTCAAATTTATAAACTGCCACACTTGGCATCAGATTC
ACTTAAAAGGATATAGAATGGGAAGCACTGCTTACTAGCAAGGCAGAACCAGTTGCTCTTCTCTGAAAGTCTCTGCAGCTGTCTGTGTGG
CATAGTGCAGGTGCAAGGAGACAGATCTACATGGGGCAAGTATGGAAGCTTCCCCGGCTTAAGAGCCCCTTGTCCCACAGGAACAAGTAT
CTCTTATAACAGCTTCATAGACATGGCCTCCAGTGTCCCTATAAAAGACATGCCTGTTCCAAGCGTCACTGTACTTAGGGATGCCCAGAG
CTGAGGCTTCCTATCAGGCATTTATAGTTCTCCCAGTCCAGATGCAGTTTACCAATTGGGCATCATGTCTACCATATGTAACATTGCCTA
GCAGTTGACATATGAATTTTTATTAGGTTGCCAGGGGAACAGAGCTAGAAAGTTAACAAAGGTAAAATTCTCATGCAGAAGGGAAAGAGG
CTTTGTTAATACTTTGCCAAACACTATGCTAAGCAATTGCATAACAGATATTACACCTAATTCCTATAGAATATAGCCAGAGGAATTTCC
TAGTAAAATATAACCCACCCTAACTCATTTTTCCTTTCTTGAATAGTGTTGTTGGTGCTTAGTTGCTTGTGATTAATAGACAGTTTGCAA
ATTTTGGTAAGGTGTGTGTAAGAGTTGGCTTAACAGTCAAAATGATCCTAGCCAAAATATCATGTATCCTTTGGTGTCACTCATAATAGG
TGAGTATAGTATGTCGTACTGTAGGGACATTATTGAATGGACATGTCTGAGTATTCCATCAGTCATATTTTGATGGGAGCCTTTGGCCAT
CTGGCAAACACCAAACACAGGCTCTTGGTAACCGTGCCTTTTTTTTTTTTTTTTTTTTTTTAAAGATGGAGTTTCACTCTTGTTGCCAGG
CTGGAGTGCAGTGGTGCAATCTCGGCTCACCACAACCTCCGCCTCCTGGATTGAAGCGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGG
ATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGATCTCGGCCTG
ACCTCAGGCAATCCGCCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACTGCGTCCGGCCTGCTCTTGGAAACCGTGCCTCTT
ATTCCTGTGTCATGTGGTGCTACTCTTGCCTGCTTCTGTTGCTCCCAGCAGATCAATGAGTGAAGATGGCTGGTTACTCATTCAGTAGTT
ATCAAACAATTATTTATGGAGTCTTTACTGTATGTCAAGCACGAAGGGTACTTCAGTGAACCAGCACCATCCCTGCCCTCAAGGATCCTG
CAGTGTGTAATCACAGAGACTGGCAGTTATAACACGGCATGTTGGGTGTGACAACAGGGACAAGCACAGGGTACTCTGAGAACGCGTGGG
TCGGGTACCTAGCCAGTCATAGAGCCTCAGAGACGCTTTCTGTCTAAGCTACTCTTCCTATCCAGTAAACTTCCAGCTTTGGCATACTAT
ATTTATAAGCAGTTTAAACAGTTGCTGAAATTTATTGCCTTTTCTCAAACATGGTGGCTTTGGTCACTAACAGTGTTTAAATTATGTGTT
TTATTCAGTTATGCAAAAATATATACTATACATAGAATATCAGAATGTTGTAGTCTTTAGGAAATATGCATCAGGTTTGTTTTTTTTGTT
TTTTTGACAGACTCTCACTCTGTCGCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACCTCCGTATCCCAGGTTCAAGTGAT
TCCCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGCGTGTGCCACCACGCCCAGCTAATTTTTTGTATTTTATAAGAGATGGCGTGT
CACCATGTTGACCAGGATGGTCTTGATCTCCTGACCTCGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCA
CTGTGCCTGACTGGGTGGTTTTCTTTTTTAAAAAATAATATGGTTTTCTGGCCGGGAGCAGTGGCTCATGCCTGTAATCCCAGCACTTTG
GGAGGTCAACGGGGGTGGATCACCTGAGGTCAGGAGTTAAAGACCAGCCTGGCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAA
ACAGGAGAATCGCTTGAACTCGGGAGGTAGAGGTTGCAGTGAGCTGAGATAATGCCACTGCACTCCAGCCTGGGCGACGGAGTGAGACTC
CATCTCAAAAAAATAAAAAATAATAATAATATGGTTTTCTTATTTAAAAAATAATATAGTATGTAAATTATTTTTCAAGTAAAAATGAAA
TGACAACAACAGATAACTTCCCATTATGTTGATCCAGTGTACTGTGACAGATGGGGAGGAGCCCCACTGCATCTGGAGTGGGTCTTGGCT
GGCCATGTGAACTAATTAATACCCCAGAAATCAGGATACATGCCAGGCGTCGGGGCTTACGCCTGTAATCCCAGCATTTTGGGAGGCTAA
GGTGGGTGGATCCCTTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATATACAAAATTAGCC
TGTAATTCCAGCTACTTGGGAAGCTGAGGAAGGAGAATTGCTTGAGCCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCA
CTTCAGCCTGGGCAACGAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAAATCAGGATACATATAGGACAGAACCATT
AAATCAAGAGATTTGAAAGTTAGAAGGGACAGGAGAGATAGTCTAGTCCAACTCCATGTGACAGATGAAATGACGTTTCTAGTTCTCACA
CAGCTGGTTAGGATCAGAAACCAGGTCCTGCCAGGCCAGTCCTGATAATAGACAGACATGTTTGGGCAGGCAGAAAAGACCATTCATAGA
TAACATTTGTTTCCCTGGGTATCCATCAGACCAGAGGCACAGGAGAGGAAAATGCTGTTTTGGCCTCATATGATAAAGTATGCATTGTGT
GATTATGGTCTGCATTCTTGCAATGCTTAGACAGGGAGGGGGAAATCACATTTTGAGCATGGGGGAGTTAATTTCTTTGTCCTGTAATAC
CACACATATCTAAAACATAAACCACCATGGAACACACTCACACTCACATACACACAAAAGGCAAATTAAAATATTTATTGTCCACTTAAT
ATGTGTTCTGTGTTTGATTGTAATGTATTCATTTTACTTATAAAAAATTTCAAAAGTAAAAATATATATATTATTAACTTGAAGTGATTT
TTTCCAACCTCGCTGATTTTTTTCCTTCTTTCTTTTTTGAGACAGAGTTCCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCG
GCCCACTGCAATCTCCGCCTCCAGAGTTCAAAGAGTTCTCATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAGGTATGCCACCATGCC
CGGCTAATTTTTGTATTTTTAGAAGAGATGGGGTTTCATTTTGGTCAGGCTGGTCTCGAACTCCTAACCTCAGGTGATACACCCGCCTCA
GCCTTCCAAAGTGCTGAGATTACAGGTGTGAGCCACCATGTCCGGCCTCTAACTGATTTTTGAAATATAAATTGGGTGTGATTCAGGGAA
TGTAACAAGAACAATCTTATTTGAAACAGAAAACCACATATTTTTAAGTCAGCAGCCCACATGATAAGATGGTATTGAGTAAAAATGTAT
TCTTAGGTATTTCTTGACTCAGTGGATTTTAATCAGTCTACTGCAAAAGCTAGTTTTATTTAAAGGGCTGCAATTATATATAAGAATTAT
TAGAAAAACAGATTAGCCACTTAATCTAAAAATACCTAGATGCAGTATTCCTGGTTTTTAATGAAATATTTATCTAGTTTGGGATTAAAA
TTAACTTAGGGCCATCAAAAATGCAAATTATCTTTAATTTGGTTAAATCAACCTGGGAGTAAATGGAAATAATCTCAAGCTAAATTTTTG
TTTTGATTTATATACAGTCAGATTGAAACACCCTAGTTACAAGTTTAGAATAGGAGTGGCCTCAACAAAGGAAAAAGTCCTTTGTTCCTC
TGTTGCTCATTTTGTCCTCGGAAACAAATACAATTTAACTATTTTCTGTACCGTCCCAAATTTGAAGCTGACCTGAATTTGGTACCTATA
AATTTAAAATGGCTAAGGTTAAAATAGTTAAAACAGTTTCTTTAGAATGAGTTGTTAGCTGGGTGTGGTAGTGTACACCTGTAGTCCCAG
CTACTCCAAAGGCTGAGGCAGGAGGATTGCTTGAGCCCAGAAGTTCAAAGCTGCAGTGAACTAGGATCATGTCACCACACTCCAGCGTGG
GCAACAGAATGAGACCCTGTCTCAAAAAAAAAGGTTTTTTTTTAATTGAATGAATGCAATAAGGAATTGAGGATCGTCTCACATTAATGA
GTGAATAACCCTTCATAATTTTAGTTACTGTTTTTCTCAGGGCAATTATTTTATATAAAATTCTAATGGAGAATTTTATGGACAAGATTT
TAGTTAAGGAAAAAAATAACCCCACAAAATAAAGAGAACTATTAGAGCTCTAAACAGAAGAAGCTTCCATCAAACCGTTTTTCCCACTTT
TTTGTCCCACGGTCTTAGGACCAACAATTTAGTAATACGAGACAATTTCTGGCAGACTATCCCAAGCTGGGACATTTTAGATTCTGTGAA
AGAAGACTGACTACTGTCTGATGAATGGGTAATTGATGATGCAATGTATGAAAAAAGTAAGGCAGACAACTCAAAAATCACAGGAAGTGC
AGCCATTCTACGTGCCGAGCTCTACAGTTACACACTGTCCAACAGCTCTCGGAAGAAAAACAGAAACTGACTTTATCTTTGCCTGCCAAG
TTTGCAAATGGATTAGTTCATTACAAAGGCACTTGTCAAAACATATTTATTAAAAAGAGGAGCCAGAGTTGGAAATCATCTTGACCATTA
AAAAAATAGCAACTGATACCTTGTTTAACAAGTAAGACAGTTTCTGCTTTTTGGAATTGAATTGGTTTTTAAGTGGTAATGTACCAGGTC
TGTTTATATAGGTCAGTGTTGCCCAGGTTGTATTGTTTTGCTGTTTTTACTTTTTTATATATAAAGAACTAAAATTACGAGAGAATAAAT

>35817_35817_2_HDAC1-ZBTB8B_HDAC1_chr1_32757819_ENST00000373548_ZBTB8B_chr1_32946492_ENST00000609129_length(amino acids)=181AA_BP=0
MAQTQGTRRKVCYYYDGDVLVVPIKLHKCPFCPYTAKQKGILKRHIRSHTGERPYPCETCGKRFTRQEHLRSHALSVHRSNRPIICKGCR
RTFTSHLSQGLRRFGLCDSCTCVTDTPDDDDDLMPINLSLVEASSESQEKSDTDNDWPIYVESGEENDPAGDDSDDKPQIQPNLSDRETL

--------------------------------------------------------------
>35817_35817_3_HDAC1-ZBTB8B_HDAC1_chr1_32782383_ENST00000373548_ZBTB8B_chr1_32946492_ENST00000609129_length(transcript)=12129nt_BP=364nt
CTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCG
CAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCT
CACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAG
GAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAG
AGATGTGATGTGCTGGTGGTCCCCATCAAGCTCCACAAGTGTCCTTTCTGCCCTTACACTGCCAAACAGAAGGGCATCCTCAAGCGGCAC
ATCCGTTCACACACAGGCGAGCGGCCCTACCCCTGTGAGACCTGCGGCAAGAGGTTCACTCGACAAGAGCACCTGCGGAGCCACGCACTG
AGTGTCCACAGATCCAACCGTCCAATCATCTGCAAGGGCTGCAGGAGAACATTCACGAGTCACCTGTCCCAGGGGCTGCGGCGCTTCGGG
CTGTGTGACAGCTGCACCTGCGTTACAGACACACCCGATGATGATGATGATTTGATGCCCATCAACCTTAGCTTGGTGGAGGCTTCATCT
GAAAGCCAAGAAAAGAGCGACACAGACAATGACTGGCCAATCTATGTGGAGTCGGGTGAGGAAAATGACCCTGCTGGAGATGATTCTGAT
GACAAACCACAAATTCAGCCTAACTTATCAGACCGAGAGACACTTACGTAGCAATAAATTGGTGGGGAAGAGGAGGTTTTAAAACTTGTT
AGTGCTCGTTCTGTTGTTGAAAGATACCATTTGTCCAATTTTGTGGAACCCTGAGAGGAACATTTTTTCACTGTTATTATATGTGCATTT
TTATTAGACTATCTGATAGAGGTTGGATTTTGTGACTCAAAGGACAGATAACCTTTTTGTGTGGTGCCCTTGGTTTCTGAGGGCTTTGCT
GGCCACTCCTTAATTCTGAGTGAGTCAAAGCAGGCCCTGAGGTCTCCTGTTTTTCTTGCTGTGTGTCCAAACTCTGGTTAGGAGAAAGAT
AAGAAAATCTCCAGGCTTGTTTTTATATTGATTCAGTCCTCTGCATTCCTTTGTTATCATCCTCTTTCTCTAAAAACCATTAAGTTTTGG
GATCAAGTTTACCTTTGCCAAGCCTTTCCTAATGAATTCCACATTAAATTTTCTGGCAAAGTATTAAAGAGAAACCTTCATTGATATAAA
GCAGGCAGGGCGGTCTGGCTACATGATCATAAAAGGTACTCCCTAAATCTAGAACAATTTTAAAGGCTTGGAATACTTATGGGCAGACGA
ACATGGGAATGATCTGAAAGGCTCATTATGGCATCCTGACTTGCCCAGTTGAATTAAATTTTAAGTTAGCCCTGAGAAGGGAGGCTATGA
CCCCAGGTCTGGATGGTTTCCCTGTCTGGTTTGGCATTTGACGATTCTACACATACAACCTGTTCTGTTATCATAAAACAACTCATTTGG
GCAAAACTCAAAATGCTCCCCTACTTTTTCCAGCAATTTCCAAAAGCTGGAGCTGTGTAACTTGGAAATGTAGCTGCCTCTGGCATTCTT
TTACTTAGTTTATGCTGATGTAGGGCAGGTGAGCCCAAAAATTGGGGCTTAGCCCAGAGGAGTTCTTGGCTTCACCCAGGAAAGAATTCA
AGGGCAAGCCAGTGGTGTTAGACAGCAGCTTGTATTGAAGCAGCAGTGCCCAACAGCAGCTAAGGGGCCGCTCCTCGTGGAGCAGGGCTA
CACCATAGGCAGTGTGCCCAGAGTAGTAGCTCAGAGGCAGGTCGGCACTTATATTTATACCCACTTTTAGTTACATGCAAATTAAGGGGC
AGATTATGCAGCAATATTTAGGAAAATGGTGGTAACTTCCAAGCCGCTGGGTGGTTGCCATGATAAGGGGCAGTGACTTCCAGGTGTTGC
CATGGCAATGGTAATTGACATGGCACAGTGATAAGTGTTTCTTATGGAAATCTGCTTCCTGCACCACCCTCCCACCACCGCCCTGTTTTA
GCTAGTCCTCAATTTGGTCCATGTCCGAGTCCGGCCTTTGGAGTTGAGTCCTGCCTTCTACCTCCTTGCCTAGAACTTTAATTGGAGGGA
AAGTATAAGCCCATAATGCCAAGTAACATTTCTAAAATGTTCATCTTTTAAAAGATCTTCATGAGGGAAAGGGAAGGTTAGTAGCAGAAC
AGGTTTTTAAAAGCAGTCTACCTTTCGCCCACTTTCCAGCCACACAATTATTGTAACAAAAGAGGCTGAACTCTTTAAAGGGCTAAAGGG
CAGGCAGTGTTAGGAATTCGGAATGTAATTGAAGGCAATTTCCATAATTTTGTCTTATGTTAAAATATCCAAAATGGATTTTAAAAGAAA
TCTTCTTGTCTTCCTTTAAGTGTAGTTGTCTTTCAAAAGGTGGTAAAAGTCACTTTTATTTCTACCTCTTGAACAACAAAAAAGTCAAAA
ACATTATAAATTGGCTTGTAAATGTTAGCCAAAGCATTAGACAGGTGTTTAAGTCGTACTTCTCAATAGTAGTTAAAACTGGAACAGTGC
AACTCAAACTCTGGCCCACAGAGAGGCCCTGTTCTGTAAACTGTTTTCTACCAGTCTGCTACAAGGAAAGTCAGAAATTAAGAATACACA
TATAGAAATGTTGATAACACTTTGACATTGCTGTGACTCATGGCTTTGTCTTCTTGAGTGAGGTATGGACCAGTTCAGTTCTGGTCAGCT
AGAGGGCCACATGGTGCAGAGGTTGGATACCAGCCTGTACAGCAGGACCACGTATTGGTCTGCAGTAGAATGGAAAATTTAAAACTTCTC
TTATCACAGGTAGTTCGATAAATATCATTCTTGGCTGTGTGCGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGATG
GAACACTTGAGGTCAGGAGTTCGATACCAGCCTGACCAACATGGCGAAACCCCGTCTCTAGCAAAAATACAAAAATTAGTCAGGAGTGGT
GGCATGTGCCTGTAATCCCAGCTACTCAGGAGGCTGTGGCGAGAGGAACACTTGAGCCTGGAAAAGGTTGCAGTGAGCTGGAATCGTGCC
ACTCCACTCCAGCCTGGGCAACAGTGTGAGACCTTGTCTCAAAAAAATAATAATAAAATAAATAAATAAAAGAAAAATATTCTAGATCAA
GAGTTACTCATTGAAAATTATCAGGGACCAGAGATATTTGTCTTATCTGAAATAAAAATACTAGCTGTGGCCAGGCGCAGTGGCTCACGC
CTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGAGAAACCCCG
TCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAATTCCAGCTACTCAGGAGGCTGAAGCAGGAGAATCGCTTGA
ACCCAGGAGGCGGAGGTTGCTGTGAGCCGACATCACACCACTGCACTCCAGCCTGGGCAACAAGAGCGAAACTGTCTCCAAAAATGTATA
CATATATTTGCTGTTATTTTAAAAGAGGGATCTCAGCAAAAAGGAAACCTAAATGGATGTGTAGAAGATTTACTTGGCCAGGAACAGTGT
TTGATATTTTTGCTTTCTCTGTTTAAATTATCTCTGATGTTTTAATGACTTTTCTACCTCATAGTTCAGCCTCTTTGCCTGCTTTCTCCA
GTGGAGCTATGATCCTCTTCAGTGATTCCGTGACCTCTTCATATCCCTGGGTAAAACATTTTACATTAGAGATTTCACTGTAGGACAGTG
ATTCTCAGTTGGGGGTGATTTCGTGCCTTGCAGGTGGCTACTGGCATCTAGTGGGTAGAGGCCAGGGAAGCTGCCAAACATCCTGAAATG
CACAGGACAGTCCCCACAACAATGAATTCTCCAATTCAAAATGTCAGTAATACCAATGTTGAGAAACTCTGCTGTAAGATAAAGTAGGAT
TTTTTAAAGGATCTTTAATGAGTGGACTTAATTTTGTGTTCTATTTTAAGCTACCTTTTACCTGCATAATATTTATTTATTTTTAATTTT
ATTTTATGTATTTATTTATTTATTTTGAGATGGAGTTTCATCTTTGTCACCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACTGCAA
CCTCCACCTCCCAGGTTCAAGAGATTCTTCTGTCTCAGCCTCTTGAGTAGTTGGGATTATAGGCACGCGCCACCACGCCTGGCCAATTTT
TGTATTTTTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCTGCCTCAGCCTCCCA
AAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCTGACCTTCATAATATTTAGTAGCCCCTTATACTCTCGCAAATTTTAGAAAAT
AGTGGATTAGTAAAATGAAGCGCTGAGGCCAGATGGTTCATAGCTTGCCCAAGATCTGATTTAGGTTTATAATGTGGAAACTTAGAAAAT
TCTGACTCATTCATACACCCAGAATCGTTACTAGGTTCTGATCATTTTGTTAATTTTTAAAGTAGCAGAATCACTGGGAAGAAAACAGAA
TGTGACACCTAATGTTTAAATGATTCTCTTTCTTTCGTAATATCTCAGATTGTTGCATTTCTGGTGGACTATTTGGAGTTTGTGTATAGG
CACTGGCAATAACTGGATCACTGAGTTCTATCACTTTTAAAGGAGATACTTCCTCTGTCTAGACTATCAGATCATAAATTGGTCCCCTTT
AGGTGGTCAGTATTTATAATCACAGTGTCTTTGAGGTTTAATTTGTGGGGTTGGTGGTATTTTTATACTAAGTAAATTTACAGTTGAGCC
CAACACAGACCGTTAGTGGTTTAGTTTCTATTCTGGCACATTCCACCCAAGTTCACAAAGGGATATTTTCGTCTCATATTAGATGTATTG
CATGAATGGGAACAGGACTCTTACTTGTAATGGAATTCCAAAATGGCATTCTTGGGAAGTTATTTCTCTTGGGGGATGAGGACCCCCTTC
TCAAAAGTTGAGAAGGAATGTAAATAGGGCCTTACCTATAATAATTAAGAAATGACATAGTGCATCATGATTCTGATCATTTGGCAGAAA
GATGCCGTTCTGATGTAAATATTTTGGTGGCCACCAGACTTTGAATATTCCTTAAGGAAGCTGCTGACCTAGTGTTCTGCAACATGTTAT
GGAATTGAGTATTCTGGTGGTTTGGAATACTGAGATGGGTTTTTTTTGTTATTGTTCATTGATGTCGTGACAAACCCCAGGGAGAGAAAG
GCAACAGGTAGGGCTGCATGCACTGATTCTGGGAGCCGTAGGAAAGAGTGGAGTGGCCTTTGGTTAACTGAACTCAGACTGTTTTATTTG
GAACTCTAGATTTTTCTTGTGTGTGTCCCTTGTGCATTAAGAGAATGATCTCTGTGAAGTCTAGTGTAATGGGGTAGGGAGGGGCAAAGG
GTTGGGATGGGTGAGAAGTTCCTATTATGCTCTGTTTTGAGCATTCCCACTGTGCTTCCTGTTGTTGCTGGTCTCTTGTAGCTTGCCTTG
TGTTTTCATGTGATCACACTATCTTCTAACCTGATAAAGGGACACTTTATTCAGGTGCATATGATGGGCACTGTTTTCATTGATTTCTGT
TGCTTTTGTAGTTCTCTCCACTCAACAGTACTGTGTTCCACAAACCTTTCATTGTAGTGCTGGAAATTTGAATTCTTTTCTTCAAATGAT
GTTTCTGTAGAGAAAAACGAAAAGTGTTTTGGGGTCAGAGTAGTTTGGTTGGTTCCTAAACATGTCCTAGTTTTTGTTGTTGTTGTTGTT
TTTCTTTTCTTTTTTTTTCTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGC
CTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCATGCCCAGCTAATTTTTTGTATT
TTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATAGTCTCAATATCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTA
GGATTACAGGCGTGAGCCACCGCGCCCGGCCTAAATATATCCTAGTTTTAAAAGGTGACAGTAACTCACATGACTGCATGATCGGATGAC
ATGGAAACTTCATAACTGAAGGAGAACATTTAGCATCCGTCTTGACCCTCCAGGTAGATTATTTTACTACTGCCAATTCTTCATTGACAA
TTGTGGTTTTAGGGGGGGCAATTTTTATATCCATCATTTGATTTCTGGACCTTTGTCAGTTAATCAGTGGAGGTTAGGGCAGGGATTATG
TGCTTTGATGAGGAAGGTTTAGTAGTAACAAGCTTGGGGATTTTGAAGGAAGGCATCAATTTCATATACAGGTCTTGGTGACATGTAATG
GATATGGATTATCTGTCATGCATACAGTGAAGGGTATGGTCAGGATTTTTTTGGAAGTAGAAAAACATACCAAACAGTTTCACATCTTTT
ACCATCCATAGCCCCTGAGGAGCATCTACTGCCATCAGAAAAACATGCAAATAATACTGCAGTGCCCTCCAAGGGTCTTAGGCCCAACTG
AAGGTTTAGAAACATTCAAATTTATAAACTGCCACACTTGGCATCAGATTCACTTAAAAGGATATAGAATGGGAAGCACTGCTTACTAGC
AAGGCAGAACCAGTTGCTCTTCTCTGAAAGTCTCTGCAGCTGTCTGTGTGGCATAGTGCAGGTGCAAGGAGACAGATCTACATGGGGCAA
GTATGGAAGCTTCCCCGGCTTAAGAGCCCCTTGTCCCACAGGAACAAGTATCTCTTATAACAGCTTCATAGACATGGCCTCCAGTGTCCC
TATAAAAGACATGCCTGTTCCAAGCGTCACTGTACTTAGGGATGCCCAGAGCTGAGGCTTCCTATCAGGCATTTATAGTTCTCCCAGTCC
AGATGCAGTTTACCAATTGGGCATCATGTCTACCATATGTAACATTGCCTAGCAGTTGACATATGAATTTTTATTAGGTTGCCAGGGGAA
CAGAGCTAGAAAGTTAACAAAGGTAAAATTCTCATGCAGAAGGGAAAGAGGCTTTGTTAATACTTTGCCAAACACTATGCTAAGCAATTG
CATAACAGATATTACACCTAATTCCTATAGAATATAGCCAGAGGAATTTCCTAGTAAAATATAACCCACCCTAACTCATTTTTCCTTTCT
TGAATAGTGTTGTTGGTGCTTAGTTGCTTGTGATTAATAGACAGTTTGCAAATTTTGGTAAGGTGTGTGTAAGAGTTGGCTTAACAGTCA
AAATGATCCTAGCCAAAATATCATGTATCCTTTGGTGTCACTCATAATAGGTGAGTATAGTATGTCGTACTGTAGGGACATTATTGAATG
GACATGTCTGAGTATTCCATCAGTCATATTTTGATGGGAGCCTTTGGCCATCTGGCAAACACCAAACACAGGCTCTTGGTAACCGTGCCT
TTTTTTTTTTTTTTTTTTTTTTAAAGATGGAGTTTCACTCTTGTTGCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACCACAACCTC
CGCCTCCTGGATTGAAGCGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTGTA
TTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGATCTCGGCCTGACCTCAGGCAATCCGCCTCTGCCTCCCAAAGTGCTGGGA
TTACAGGCGTGAGTCACTGCGTCCGGCCTGCTCTTGGAAACCGTGCCTCTTATTCCTGTGTCATGTGGTGCTACTCTTGCCTGCTTCTGT
TGCTCCCAGCAGATCAATGAGTGAAGATGGCTGGTTACTCATTCAGTAGTTATCAAACAATTATTTATGGAGTCTTTACTGTATGTCAAG
CACGAAGGGTACTTCAGTGAACCAGCACCATCCCTGCCCTCAAGGATCCTGCAGTGTGTAATCACAGAGACTGGCAGTTATAACACGGCA
TGTTGGGTGTGACAACAGGGACAAGCACAGGGTACTCTGAGAACGCGTGGGTCGGGTACCTAGCCAGTCATAGAGCCTCAGAGACGCTTT
CTGTCTAAGCTACTCTTCCTATCCAGTAAACTTCCAGCTTTGGCATACTATATTTATAAGCAGTTTAAACAGTTGCTGAAATTTATTGCC
TTTTCTCAAACATGGTGGCTTTGGTCACTAACAGTGTTTAAATTATGTGTTTTATTCAGTTATGCAAAAATATATACTATACATAGAATA
TCAGAATGTTGTAGTCTTTAGGAAATATGCATCAGGTTTGTTTTTTTTGTTTTTTTGACAGACTCTCACTCTGTCGCCAGGCTGGAGTGC
AGTGGCGCGATCTTGGCTCACTGCAACCTCCGTATCCCAGGTTCAAGTGATTCCCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGC
GTGTGCCACCACGCCCAGCTAATTTTTTGTATTTTATAAGAGATGGCGTGTCACCATGTTGACCAGGATGGTCTTGATCTCCTGACCTCG
TGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCTGACTGGGTGGTTTTCTTTTTTAAAAAATAAT
ATGGTTTTCTGGCCGGGAGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGTCAACGGGGGTGGATCACCTGAGGTCAGGAGTTA
AAGACCAGCCTGGCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAAACAGGAGAATCGCTTGAACTCGGGAGGTAGAGGTTGCAG
TGAGCTGAGATAATGCCACTGCACTCCAGCCTGGGCGACGGAGTGAGACTCCATCTCAAAAAAATAAAAAATAATAATAATATGGTTTTC
TTATTTAAAAAATAATATAGTATGTAAATTATTTTTCAAGTAAAAATGAAATGACAACAACAGATAACTTCCCATTATGTTGATCCAGTG
TACTGTGACAGATGGGGAGGAGCCCCACTGCATCTGGAGTGGGTCTTGGCTGGCCATGTGAACTAATTAATACCCCAGAAATCAGGATAC
ATGCCAGGCGTCGGGGCTTACGCCTGTAATCCCAGCATTTTGGGAGGCTAAGGTGGGTGGATCCCTTGAGGTCAGGAGTTTGAGACCAGC
CTGACCAACATGGTGAAACCCCATCTCTACTAAAAATATACAAAATTAGCCTGTAATTCCAGCTACTTGGGAAGCTGAGGAAGGAGAATT
GCTTGAGCCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTTCAGCCTGGGCAACGAGAGCAAAACTCCATCTCAAAA
AAAAAAAAAAAAAAAAAAAAGAAATCAGGATACATATAGGACAGAACCATTAAATCAAGAGATTTGAAAGTTAGAAGGGACAGGAGAGAT
AGTCTAGTCCAACTCCATGTGACAGATGAAATGACGTTTCTAGTTCTCACACAGCTGGTTAGGATCAGAAACCAGGTCCTGCCAGGCCAG
TCCTGATAATAGACAGACATGTTTGGGCAGGCAGAAAAGACCATTCATAGATAACATTTGTTTCCCTGGGTATCCATCAGACCAGAGGCA
CAGGAGAGGAAAATGCTGTTTTGGCCTCATATGATAAAGTATGCATTGTGTGATTATGGTCTGCATTCTTGCAATGCTTAGACAGGGAGG
GGGAAATCACATTTTGAGCATGGGGGAGTTAATTTCTTTGTCCTGTAATACCACACATATCTAAAACATAAACCACCATGGAACACACTC
ACACTCACATACACACAAAAGGCAAATTAAAATATTTATTGTCCACTTAATATGTGTTCTGTGTTTGATTGTAATGTATTCATTTTACTT
ATAAAAAATTTCAAAAGTAAAAATATATATATTATTAACTTGAAGTGATTTTTTCCAACCTCGCTGATTTTTTTCCTTCTTTCTTTTTTG
AGACAGAGTTCCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCCCACTGCAATCTCCGCCTCCAGAGTTCAAAGAGTTCT
CATGCCTCAGCCTCCTGAGTAGCTGGGATTACAGAGGTATGCCACCATGCCCGGCTAATTTTTGTATTTTTAGAAGAGATGGGGTTTCAT
TTTGGTCAGGCTGGTCTCGAACTCCTAACCTCAGGTGATACACCCGCCTCAGCCTTCCAAAGTGCTGAGATTACAGGTGTGAGCCACCAT
GTCCGGCCTCTAACTGATTTTTGAAATATAAATTGGGTGTGATTCAGGGAATGTAACAAGAACAATCTTATTTGAAACAGAAAACCACAT
ATTTTTAAGTCAGCAGCCCACATGATAAGATGGTATTGAGTAAAAATGTATTCTTAGGTATTTCTTGACTCAGTGGATTTTAATCAGTCT
ACTGCAAAAGCTAGTTTTATTTAAAGGGCTGCAATTATATATAAGAATTATTAGAAAAACAGATTAGCCACTTAATCTAAAAATACCTAG
ATGCAGTATTCCTGGTTTTTAATGAAATATTTATCTAGTTTGGGATTAAAATTAACTTAGGGCCATCAAAAATGCAAATTATCTTTAATT
TGGTTAAATCAACCTGGGAGTAAATGGAAATAATCTCAAGCTAAATTTTTGTTTTGATTTATATACAGTCAGATTGAAACACCCTAGTTA
CAAGTTTAGAATAGGAGTGGCCTCAACAAAGGAAAAAGTCCTTTGTTCCTCTGTTGCTCATTTTGTCCTCGGAAACAAATACAATTTAAC
TATTTTCTGTACCGTCCCAAATTTGAAGCTGACCTGAATTTGGTACCTATAAATTTAAAATGGCTAAGGTTAAAATAGTTAAAACAGTTT
CTTTAGAATGAGTTGTTAGCTGGGTGTGGTAGTGTACACCTGTAGTCCCAGCTACTCCAAAGGCTGAGGCAGGAGGATTGCTTGAGCCCA
GAAGTTCAAAGCTGCAGTGAACTAGGATCATGTCACCACACTCCAGCGTGGGCAACAGAATGAGACCCTGTCTCAAAAAAAAAGGTTTTT
TTTTAATTGAATGAATGCAATAAGGAATTGAGGATCGTCTCACATTAATGAGTGAATAACCCTTCATAATTTTAGTTACTGTTTTTCTCA
GGGCAATTATTTTATATAAAATTCTAATGGAGAATTTTATGGACAAGATTTTAGTTAAGGAAAAAAATAACCCCACAAAATAAAGAGAAC
TATTAGAGCTCTAAACAGAAGAAGCTTCCATCAAACCGTTTTTCCCACTTTTTTGTCCCACGGTCTTAGGACCAACAATTTAGTAATACG
AGACAATTTCTGGCAGACTATCCCAAGCTGGGACATTTTAGATTCTGTGAAAGAAGACTGACTACTGTCTGATGAATGGGTAATTGATGA
TGCAATGTATGAAAAAAGTAAGGCAGACAACTCAAAAATCACAGGAAGTGCAGCCATTCTACGTGCCGAGCTCTACAGTTACACACTGTC
CAACAGCTCTCGGAAGAAAAACAGAAACTGACTTTATCTTTGCCTGCCAAGTTTGCAAATGGATTAGTTCATTACAAAGGCACTTGTCAA
AACATATTTATTAAAAAGAGGAGCCAGAGTTGGAAATCATCTTGACCATTAAAAAAATAGCAACTGATACCTTGTTTAACAAGTAAGACA
GTTTCTGCTTTTTGGAATTGAATTGGTTTTTAAGTGGTAATGTACCAGGTCTGTTTATATAGGTCAGTGTTGCCCAGGTTGTATTGTTTT

>35817_35817_3_HDAC1-ZBTB8B_HDAC1_chr1_32782383_ENST00000373548_ZBTB8B_chr1_32946492_ENST00000609129_length(amino acids)=258AA_BP=0
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ
MQRCDVLVVPIKLHKCPFCPYTAKQKGILKRHIRSHTGERPYPCETCGKRFTRQEHLRSHALSVHRSNRPIICKGCRRTFTSHLSQGLRR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HDAC1-ZBTB8B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HDAC1-ZBTB8B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HDAC1-ZBTB8B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource