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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HDAC7-IRAK4 (FusionGDB2 ID:35861) |
Fusion Gene Summary for HDAC7-IRAK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HDAC7-IRAK4 | Fusion gene ID: 35861 | Hgene | Tgene | Gene symbol | HDAC7 | IRAK4 | Gene ID | 51564 | 51135 |
| Gene name | histone deacetylase 7 | interleukin 1 receptor associated kinase 4 | |
| Synonyms | HD7|HD7A|HDAC7A | IPD1|IRAK-4|NY-REN-64|REN64 | |
| Cytomap | 12q13.11 | 12q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone deacetylase 7histone deacetylase 7A | interleukin-1 receptor-associated kinase 4renal carcinoma antigen NY-REN-64 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q8WUI4 | Q9NWZ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000080059, ENST00000354334, ENST00000380610, ENST00000427332, ENST00000552960, ENST00000488927, | ENST00000431837, ENST00000448290, ENST00000551736, ENST00000440781, | |
| Fusion gene scores | * DoF score | 11 X 8 X 6=528 | 5 X 5 X 5=125 |
| # samples | 15 | 6 | |
| ** MAII score | log2(15/528*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HDAC7 [Title/Abstract] AND IRAK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HDAC7(48185042)-IRAK4(44161906), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HDAC7 | GO:0032703 | negative regulation of interleukin-2 production | 17360565 |
| Fusion gene breakpoints across HDAC7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across IRAK4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-E2-A14T-01A | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
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Fusion Gene ORF analysis for HDAC7-IRAK4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000080059 | ENST00000431837 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000080059 | ENST00000448290 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000080059 | ENST00000551736 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000354334 | ENST00000431837 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000354334 | ENST00000448290 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000354334 | ENST00000551736 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000380610 | ENST00000431837 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000380610 | ENST00000448290 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000380610 | ENST00000551736 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000427332 | ENST00000431837 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000427332 | ENST00000448290 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000427332 | ENST00000551736 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000552960 | ENST00000431837 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000552960 | ENST00000448290 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-5UTR | ENST00000552960 | ENST00000551736 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-intron | ENST00000080059 | ENST00000440781 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-intron | ENST00000354334 | ENST00000440781 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-intron | ENST00000380610 | ENST00000440781 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-intron | ENST00000427332 | ENST00000440781 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5CDS-intron | ENST00000552960 | ENST00000440781 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5UTR-5UTR | ENST00000488927 | ENST00000431837 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5UTR-5UTR | ENST00000488927 | ENST00000448290 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5UTR-5UTR | ENST00000488927 | ENST00000551736 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| 5UTR-intron | ENST00000488927 | ENST00000440781 | HDAC7 | chr12 | 48185042 | - | IRAK4 | chr12 | 44161906 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HDAC7-IRAK4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| HDAC7 | chr12 | 48185041 | - | IRAK4 | chr12 | 44161905 | + | 0.2878307 | 0.7121693 |
| HDAC7 | chr12 | 48185041 | - | IRAK4 | chr12 | 44161905 | + | 0.2878307 | 0.7121693 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HDAC7-IRAK4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48185042/:44161906) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HDAC7 | IRAK4 |
| FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758}. | FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HDAC7-IRAK4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for HDAC7-IRAK4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HDAC7-IRAK4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HDAC7-IRAK4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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