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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HEBP1-NCK1 (FusionGDB2 ID:35999)

Fusion Gene Summary for HEBP1-NCK1

check button Fusion gene summary
Fusion gene informationFusion gene name: HEBP1-NCK1
Fusion gene ID: 35999
HgeneTgene
Gene symbol

HEBP1

NCK1

Gene ID

50865

4690

Gene nameheme binding protein 1NCK adaptor protein 1
SynonymsHBP|HEBPNCK|NCKalpha|nck-1
Cytomap

12p13.1

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionheme-binding protein 1p22HBPcytoplasmic protein NCK1NCK tyrosine kinaseSH2/SH3 adaptor protein NCK-alphamelanoma NCK proteinnon-catalytic region of tyrosine kinase
Modification date2020031320200327
UniProtAcc

Q9NRV9

P16333

Ensembl transtripts involved in fusion geneENST00000014930, ENST00000536942, 
ENST00000540916, 		ENST00000469404, 
ENST00000288986, ENST00000481752, 
Fusion gene scores* DoF score5 X 4 X 3=609 X 5 X 9=405
# samples 612
** MAII scorelog2(6/60*10)=0log2(12/405*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HEBP1 [Title/Abstract] AND NCK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHEBP1(13140086)-NCK1(136667101), # samples:3
NCK1(136665137)-HEBP1(13128413), # samples:5
Anticipated loss of major functional domain due to fusion event.HEBP1-NCK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCK1

GO:0033137

negative regulation of peptidyl-serine phosphorylation

14676213|16835242

TgeneNCK1

GO:0036493

positive regulation of translation in response to endoplasmic reticulum stress

14676213

TgeneNCK1

GO:0045944

positive regulation of transcription by RNA polymerase II

10026169

TgeneNCK1

GO:0060548

negative regulation of cell death

18835251

TgeneNCK1

GO:0070262

peptidyl-serine dephosphorylation

16835242

TgeneNCK1

GO:1902237

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

14676213

TgeneNCK1

GO:1903676

positive regulation of cap-dependent translational initiation

11959995

TgeneNCK1

GO:1903679

positive regulation of cap-independent translational initiation

11959995

TgeneNCK1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

14676213

TgeneNCK1

GO:1903912

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

14676213|16835242

TgeneNCK1

GO:1990441

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

16835242


check buttonFusion gene breakpoints across HEBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-QK-A8ZB-01AHEBP1chr12

13140086

-NCK1chr3

136667101

+
ChimerDB4HNSCTCGA-QK-A8ZBHEBP1chr12

13140085

-NCK1chr3

136667100

+
ChimerDB4HNSCTCGA-QK-A8ZBHEBP1chr12

13140086

-NCK1chr3

136667101

+


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Fusion Gene ORF analysis for HEBP1-NCK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000014930ENST00000469404HEBP1chr12

13140086

-NCK1chr3

136667101

+
Frame-shiftENST00000014930ENST00000469404HEBP1chr12

13140085

-NCK1chr3

136667100

+
In-frameENST00000014930ENST00000288986HEBP1chr12

13140086

-NCK1chr3

136667101

+
In-frameENST00000014930ENST00000288986HEBP1chr12

13140085

-NCK1chr3

136667100

+
In-frameENST00000014930ENST00000481752HEBP1chr12

13140086

-NCK1chr3

136667101

+
In-frameENST00000014930ENST00000481752HEBP1chr12

13140085

-NCK1chr3

136667100

+
intron-3CDSENST00000536942ENST00000288986HEBP1chr12

13140086

-NCK1chr3

136667101

+
intron-3CDSENST00000536942ENST00000288986HEBP1chr12

13140085

-NCK1chr3

136667100

+
intron-3CDSENST00000536942ENST00000469404HEBP1chr12

13140086

-NCK1chr3

136667101

+
intron-3CDSENST00000536942ENST00000469404HEBP1chr12

13140085

-NCK1chr3

136667100

+
intron-3CDSENST00000536942ENST00000481752HEBP1chr12

13140086

-NCK1chr3

136667101

+
intron-3CDSENST00000536942ENST00000481752HEBP1chr12

13140085

-NCK1chr3

136667100

+
intron-3CDSENST00000540916ENST00000288986HEBP1chr12

13140086

-NCK1chr3

136667101

+
intron-3CDSENST00000540916ENST00000288986HEBP1chr12

13140085

-NCK1chr3

136667100

+
intron-3CDSENST00000540916ENST00000469404HEBP1chr12

13140086

-NCK1chr3

136667101

+
intron-3CDSENST00000540916ENST00000469404HEBP1chr12

13140085

-NCK1chr3

136667100

+
intron-3CDSENST00000540916ENST00000481752HEBP1chr12

13140086

-NCK1chr3

136667101

+
intron-3CDSENST00000540916ENST00000481752HEBP1chr12

13140085

-NCK1chr3

136667100

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000014930HEBP1chr1213140086-ENST00000288986NCK1chr3136667101+142555733581182
ENST00000014930HEBP1chr1213140086-ENST00000481752NCK1chr3136667101+142555733581182
ENST00000014930HEBP1chr1213140085-ENST00000288986NCK1chr3136667100+142555733581182
ENST00000014930HEBP1chr1213140085-ENST00000481752NCK1chr3136667100+142555733581182

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000014930ENST00000288986HEBP1chr1213140086-NCK1chr3136667101+0.0026154470.9973846
ENST00000014930ENST00000481752HEBP1chr1213140086-NCK1chr3136667101+0.0026154470.9973846
ENST00000014930ENST00000288986HEBP1chr1213140085-NCK1chr3136667100+0.0026154470.9973846
ENST00000014930ENST00000481752HEBP1chr1213140085-NCK1chr3136667100+0.0026154470.9973846

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Fusion Genomic Features for HEBP1-NCK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HEBP1chr1213140085-NCK1chr3136667100+4.46E-060.9999956
HEBP1chr1213140085-NCK1chr3136667100+4.46E-060.9999956
HEBP1chr1213140085-NCK1chr3136667100+4.46E-060.9999956
HEBP1chr1213140085-NCK1chr3136667100+4.46E-060.9999956

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HEBP1-NCK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:13140086/chr3:136667101)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HEBP1

Q9NRV9

NCK1

P16333

FUNCTION: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities. {ECO:0000269|PubMed:12413491}.FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCK1chr12:13140085chr3:136667100ENST0000046940413282_376249314.0DomainSH2
TgeneNCK1chr12:13140086chr3:136667101ENST0000046940413282_376249314.0DomainSH2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCK1chr12:13140085chr3:136667100ENST0000028898624106_165313378.0DomainSH3 2
TgeneNCK1chr12:13140085chr3:136667100ENST0000028898624190_252313378.0DomainSH3 3
TgeneNCK1chr12:13140085chr3:136667100ENST0000028898624282_376313378.0DomainSH2
TgeneNCK1chr12:13140085chr3:136667100ENST00000288986242_61313378.0DomainSH3 1
TgeneNCK1chr12:13140085chr3:136667100ENST0000046940413106_165249314.0DomainSH3 2
TgeneNCK1chr12:13140085chr3:136667100ENST0000046940413190_252249314.0DomainSH3 3
TgeneNCK1chr12:13140085chr3:136667100ENST00000469404132_61249314.0DomainSH3 1
TgeneNCK1chr12:13140085chr3:136667100ENST0000048175224106_165313378.0DomainSH3 2
TgeneNCK1chr12:13140085chr3:136667100ENST0000048175224190_252313378.0DomainSH3 3
TgeneNCK1chr12:13140085chr3:136667100ENST0000048175224282_376313378.0DomainSH2
TgeneNCK1chr12:13140085chr3:136667100ENST00000481752242_61313378.0DomainSH3 1
TgeneNCK1chr12:13140086chr3:136667101ENST0000028898624106_165313378.0DomainSH3 2
TgeneNCK1chr12:13140086chr3:136667101ENST0000028898624190_252313378.0DomainSH3 3
TgeneNCK1chr12:13140086chr3:136667101ENST0000028898624282_376313378.0DomainSH2
TgeneNCK1chr12:13140086chr3:136667101ENST00000288986242_61313378.0DomainSH3 1
TgeneNCK1chr12:13140086chr3:136667101ENST0000046940413106_165249314.0DomainSH3 2
TgeneNCK1chr12:13140086chr3:136667101ENST0000046940413190_252249314.0DomainSH3 3
TgeneNCK1chr12:13140086chr3:136667101ENST00000469404132_61249314.0DomainSH3 1
TgeneNCK1chr12:13140086chr3:136667101ENST0000048175224106_165313378.0DomainSH3 2
TgeneNCK1chr12:13140086chr3:136667101ENST0000048175224190_252313378.0DomainSH3 3
TgeneNCK1chr12:13140086chr3:136667101ENST0000048175224282_376313378.0DomainSH2
TgeneNCK1chr12:13140086chr3:136667101ENST00000481752242_61313378.0DomainSH3 1


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Fusion Gene Sequence for HEBP1-NCK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>35999_35999_1_HEBP1-NCK1_HEBP1_chr12_13140085_ENST00000014930_NCK1_chr3_136667100_ENST00000288986_length(transcript)=1425nt_BP=557nt
CTCGCCGCCTCGCCGTCCCGCCGCCTTGCCGCCCTGCCACCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCGGTGGTCGC
TGCCCGTGGTGCTCCGTCGCCCCCGCCACCTCACGTCCTCCCGTGCGTCGGGAGCGTCTCGGCTACAACATGTTGGGCATGATCAAGAAC
TCGCTGTTCGGAAGCGTAGAGACGTGGCCTTGGCAGGTCCTAAGCAAAGGGGACAAGGAAGAAGTTGCCTATGAAGAAAGGGCCTGTGAA
GGCGGCAAATTTGCCACAGTAGAAGTGACAGATAAGCCTGTGGATGAGGCTCTACGGGAAGCAATGCCCAAGGTCGCAAAGTATGCGGGG
GGCACCAATGACAAGGGAATTGGGATGGGGATGACAGTCCCTATTTCCTTTGCTGTGTTCCCCAATGAAGATGGCTCTCTGCAGAAGAAA
TTAAAAGTCTGGTTCCGGATTCCAAACCAATTTCAAAGCGACCCACCAGCTCCCAGTGACAAAAGCGTTAAGATTGAGGAACGGGAAGGC
ATCACTGTCTATTCCATCCAAATGATTTCTCAGTATCACTAAAAGCACAAGGGAAAAACAAGCATTTTAAAGTCCAACTAAAAGAGACTG
TCTACTGCATTGGGCAGCGTAAATTCAGCACCATGGAAGAACTTGTAGAACATTACAAAAAGGCACCAATTTTTACAAGTGAACAAGGAG
AAAAATTATATCTTGTCAAGCATTTATCATGATACTGCTGACCAGAAGTGACTGCTGTGTAGCTGTAATTTGTCATGTAATTGAAGACTG
AGAAAATGTTGGGTCCAGTCGTGCTTGATTGGAAATTGTTGTTTCTAAATCTATATGAGAATTGACAATAAGTATTTTTATTATAACTCA
GCCCATACATATATACTATGTATGCAGTGCATCTGCATAGAACAGTTCCTTATCCTTGGCCTTCTGTTTTATTGTTTTTTTCTTTGCTGT
TTTCCCTTTGCTTCTAATATTACAGTTTTGTATTTTGTAAACAAAAATCAAATAATGCATATCAGAATCTTTATATGGAAGAAATCCTTT
ATTGCCTTTCCTTTGTTTCCTTGTAAAGGCACCCTGTTCTGTTATGGTTTTTCATTATATAAAATTATTATATCTATATATGACATATGC
TAAAATTTCTTGGAGAGTGTTAATCTTTTCTGTGACTAAATAGCAATAATAAGTGGAAAATTAGAAATTATTTCCAGGTATTATATTTGT
CACAGGCCATTGTAAATACCAAGTATATTGTGTCTGCCATAATTTTTAAAAATACATTCATTGTCTTCAGTCATACAGCAAGACACATGA

>35999_35999_1_HEBP1-NCK1_HEBP1_chr12_13140085_ENST00000014930_NCK1_chr3_136667100_ENST00000288986_length(amino acids)=182AA_BP=
MPPCRPAALPPCRPAAGGRCPWCSVAPATSRPPVRRERLGYNMLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTD
KPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSIQMISQ

--------------------------------------------------------------
>35999_35999_2_HEBP1-NCK1_HEBP1_chr12_13140085_ENST00000014930_NCK1_chr3_136667100_ENST00000481752_length(transcript)=1425nt_BP=557nt
CTCGCCGCCTCGCCGTCCCGCCGCCTTGCCGCCCTGCCACCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCGGTGGTCGC
TGCCCGTGGTGCTCCGTCGCCCCCGCCACCTCACGTCCTCCCGTGCGTCGGGAGCGTCTCGGCTACAACATGTTGGGCATGATCAAGAAC
TCGCTGTTCGGAAGCGTAGAGACGTGGCCTTGGCAGGTCCTAAGCAAAGGGGACAAGGAAGAAGTTGCCTATGAAGAAAGGGCCTGTGAA
GGCGGCAAATTTGCCACAGTAGAAGTGACAGATAAGCCTGTGGATGAGGCTCTACGGGAAGCAATGCCCAAGGTCGCAAAGTATGCGGGG
GGCACCAATGACAAGGGAATTGGGATGGGGATGACAGTCCCTATTTCCTTTGCTGTGTTCCCCAATGAAGATGGCTCTCTGCAGAAGAAA
TTAAAAGTCTGGTTCCGGATTCCAAACCAATTTCAAAGCGACCCACCAGCTCCCAGTGACAAAAGCGTTAAGATTGAGGAACGGGAAGGC
ATCACTGTCTATTCCATCCAAATGATTTCTCAGTATCACTAAAAGCACAAGGGAAAAACAAGCATTTTAAAGTCCAACTAAAAGAGACTG
TCTACTGCATTGGGCAGCGTAAATTCAGCACCATGGAAGAACTTGTAGAACATTACAAAAAGGCACCAATTTTTACAAGTGAACAAGGAG
AAAAATTATATCTTGTCAAGCATTTATCATGATACTGCTGACCAGAAGTGACTGCTGTGTAGCTGTAATTTGTCATGTAATTGAAGACTG
AGAAAATGTTGGGTCCAGTCGTGCTTGATTGGAAATTGTTGTTTCTAAATCTATATGAGAATTGACAATAAGTATTTTTATTATAACTCA
GCCCATACATATATACTATGTATGCAGTGCATCTGCATAGAACAGTTCCTTATCCTTGGCCTTCTGTTTTATTGTTTTTTTCTTTGCTGT
TTTCCCTTTGCTTCTAATATTACAGTTTTGTATTTTGTAAACAAAAATCAAATAATGCATATCAGAATCTTTATATGGAAGAAATCCTTT
ATTGCCTTTCCTTTGTTTCCTTGTAAAGGCACCCTGTTCTGTTATGGTTTTTCATTATATAAAATTATTATATCTATATATGACATATGC
TAAAATTTCTTGGAGAGTGTTAATCTTTTCTGTGACTAAATAGCAATAATAAGTGGAAAATTAGAAATTATTTCCAGGTATTATATTTGT
CACAGGCCATTGTAAATACCAAGTATATTGTGTCTGCCATAATTTTTAAAAATACATTCATTGTCTTCAGTCATACAGCAAGACACATGA

>35999_35999_2_HEBP1-NCK1_HEBP1_chr12_13140085_ENST00000014930_NCK1_chr3_136667100_ENST00000481752_length(amino acids)=182AA_BP=
MPPCRPAALPPCRPAAGGRCPWCSVAPATSRPPVRRERLGYNMLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTD
KPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSIQMISQ

--------------------------------------------------------------
>35999_35999_3_HEBP1-NCK1_HEBP1_chr12_13140086_ENST00000014930_NCK1_chr3_136667101_ENST00000288986_length(transcript)=1425nt_BP=557nt
CTCGCCGCCTCGCCGTCCCGCCGCCTTGCCGCCCTGCCACCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCGGTGGTCGC
TGCCCGTGGTGCTCCGTCGCCCCCGCCACCTCACGTCCTCCCGTGCGTCGGGAGCGTCTCGGCTACAACATGTTGGGCATGATCAAGAAC
TCGCTGTTCGGAAGCGTAGAGACGTGGCCTTGGCAGGTCCTAAGCAAAGGGGACAAGGAAGAAGTTGCCTATGAAGAAAGGGCCTGTGAA
GGCGGCAAATTTGCCACAGTAGAAGTGACAGATAAGCCTGTGGATGAGGCTCTACGGGAAGCAATGCCCAAGGTCGCAAAGTATGCGGGG
GGCACCAATGACAAGGGAATTGGGATGGGGATGACAGTCCCTATTTCCTTTGCTGTGTTCCCCAATGAAGATGGCTCTCTGCAGAAGAAA
TTAAAAGTCTGGTTCCGGATTCCAAACCAATTTCAAAGCGACCCACCAGCTCCCAGTGACAAAAGCGTTAAGATTGAGGAACGGGAAGGC
ATCACTGTCTATTCCATCCAAATGATTTCTCAGTATCACTAAAAGCACAAGGGAAAAACAAGCATTTTAAAGTCCAACTAAAAGAGACTG
TCTACTGCATTGGGCAGCGTAAATTCAGCACCATGGAAGAACTTGTAGAACATTACAAAAAGGCACCAATTTTTACAAGTGAACAAGGAG
AAAAATTATATCTTGTCAAGCATTTATCATGATACTGCTGACCAGAAGTGACTGCTGTGTAGCTGTAATTTGTCATGTAATTGAAGACTG
AGAAAATGTTGGGTCCAGTCGTGCTTGATTGGAAATTGTTGTTTCTAAATCTATATGAGAATTGACAATAAGTATTTTTATTATAACTCA
GCCCATACATATATACTATGTATGCAGTGCATCTGCATAGAACAGTTCCTTATCCTTGGCCTTCTGTTTTATTGTTTTTTTCTTTGCTGT
TTTCCCTTTGCTTCTAATATTACAGTTTTGTATTTTGTAAACAAAAATCAAATAATGCATATCAGAATCTTTATATGGAAGAAATCCTTT
ATTGCCTTTCCTTTGTTTCCTTGTAAAGGCACCCTGTTCTGTTATGGTTTTTCATTATATAAAATTATTATATCTATATATGACATATGC
TAAAATTTCTTGGAGAGTGTTAATCTTTTCTGTGACTAAATAGCAATAATAAGTGGAAAATTAGAAATTATTTCCAGGTATTATATTTGT
CACAGGCCATTGTAAATACCAAGTATATTGTGTCTGCCATAATTTTTAAAAATACATTCATTGTCTTCAGTCATACAGCAAGACACATGA

>35999_35999_3_HEBP1-NCK1_HEBP1_chr12_13140086_ENST00000014930_NCK1_chr3_136667101_ENST00000288986_length(amino acids)=182AA_BP=
MPPCRPAALPPCRPAAGGRCPWCSVAPATSRPPVRRERLGYNMLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTD
KPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSIQMISQ

--------------------------------------------------------------
>35999_35999_4_HEBP1-NCK1_HEBP1_chr12_13140086_ENST00000014930_NCK1_chr3_136667101_ENST00000481752_length(transcript)=1425nt_BP=557nt
CTCGCCGCCTCGCCGTCCCGCCGCCTTGCCGCCCTGCCACCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCCTGCCGCCGGTGGTCGC
TGCCCGTGGTGCTCCGTCGCCCCCGCCACCTCACGTCCTCCCGTGCGTCGGGAGCGTCTCGGCTACAACATGTTGGGCATGATCAAGAAC
TCGCTGTTCGGAAGCGTAGAGACGTGGCCTTGGCAGGTCCTAAGCAAAGGGGACAAGGAAGAAGTTGCCTATGAAGAAAGGGCCTGTGAA
GGCGGCAAATTTGCCACAGTAGAAGTGACAGATAAGCCTGTGGATGAGGCTCTACGGGAAGCAATGCCCAAGGTCGCAAAGTATGCGGGG
GGCACCAATGACAAGGGAATTGGGATGGGGATGACAGTCCCTATTTCCTTTGCTGTGTTCCCCAATGAAGATGGCTCTCTGCAGAAGAAA
TTAAAAGTCTGGTTCCGGATTCCAAACCAATTTCAAAGCGACCCACCAGCTCCCAGTGACAAAAGCGTTAAGATTGAGGAACGGGAAGGC
ATCACTGTCTATTCCATCCAAATGATTTCTCAGTATCACTAAAAGCACAAGGGAAAAACAAGCATTTTAAAGTCCAACTAAAAGAGACTG
TCTACTGCATTGGGCAGCGTAAATTCAGCACCATGGAAGAACTTGTAGAACATTACAAAAAGGCACCAATTTTTACAAGTGAACAAGGAG
AAAAATTATATCTTGTCAAGCATTTATCATGATACTGCTGACCAGAAGTGACTGCTGTGTAGCTGTAATTTGTCATGTAATTGAAGACTG
AGAAAATGTTGGGTCCAGTCGTGCTTGATTGGAAATTGTTGTTTCTAAATCTATATGAGAATTGACAATAAGTATTTTTATTATAACTCA
GCCCATACATATATACTATGTATGCAGTGCATCTGCATAGAACAGTTCCTTATCCTTGGCCTTCTGTTTTATTGTTTTTTTCTTTGCTGT
TTTCCCTTTGCTTCTAATATTACAGTTTTGTATTTTGTAAACAAAAATCAAATAATGCATATCAGAATCTTTATATGGAAGAAATCCTTT
ATTGCCTTTCCTTTGTTTCCTTGTAAAGGCACCCTGTTCTGTTATGGTTTTTCATTATATAAAATTATTATATCTATATATGACATATGC
TAAAATTTCTTGGAGAGTGTTAATCTTTTCTGTGACTAAATAGCAATAATAAGTGGAAAATTAGAAATTATTTCCAGGTATTATATTTGT
CACAGGCCATTGTAAATACCAAGTATATTGTGTCTGCCATAATTTTTAAAAATACATTCATTGTCTTCAGTCATACAGCAAGACACATGA

>35999_35999_4_HEBP1-NCK1_HEBP1_chr12_13140086_ENST00000014930_NCK1_chr3_136667101_ENST00000481752_length(amino acids)=182AA_BP=
MPPCRPAALPPCRPAAGGRCPWCSVAPATSRPPVRRERLGYNMLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTD
KPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSIQMISQ

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Fusion Gene PPI Analysis for HEBP1-NCK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HEBP1-NCK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HEBP1-NCK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource