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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HECTD4-HSPB8 (FusionGDB2 ID:36036) |
Fusion Gene Summary for HECTD4-HSPB8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HECTD4-HSPB8 | Fusion gene ID: 36036 | Hgene | Tgene | Gene symbol | HECTD4 | HSPB8 | Gene ID | 283450 | 26353 |
| Gene name | HECT domain E3 ubiquitin protein ligase 4 | heat shock protein family B (small) member 8 | |
| Synonyms | C12ord51|C12orf51|HEEL|POTAGE | CMT2L|DHMN2|E2IG1|H11|HMN2|HMN2A|HSP22 | |
| Cytomap | 12q24.13 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable E3 ubiquitin-protein ligase HECTD4AF-1 specific protein phosphataseHECT domain containing E3 ubiquitin protein ligase 4HECT domain-containing protein 4HECT-type E3 ubiquitin transferase HECTD4probable E3 ubiquitin-protein ligase C12orf51tra | heat shock protein beta-8E2-induced gene 1 proteinalpha-crystallin C chainheat shock 22kDa protein 8heat shock 27kDa protein 8protein kinase H11small stress protein-like protein HSP22 | |
| Modification date | 20200313 | 20200328 | |
| UniProtAcc | Q9Y4D8 | Q9UJY1 | |
| Ensembl transtripts involved in fusion gene | ENST00000377560, ENST00000430131, ENST00000550722, ENST00000549141, | ENST00000542496, ENST00000281938, | |
| Fusion gene scores | * DoF score | 22 X 15 X 10=3300 | 7 X 5 X 4=140 |
| # samples | 20 | 7 | |
| ** MAII score | log2(20/3300*10)=-4.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HECTD4 [Title/Abstract] AND HSPB8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HECTD4(112628590)-HSPB8(119624830), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | HECTD4-HSPB8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across HECTD4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across HSPB8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-OY-A56P-01A | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
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Fusion Gene ORF analysis for HECTD4-HSPB8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000377560 | ENST00000542496 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| 5CDS-3UTR | ENST00000430131 | ENST00000542496 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| 5CDS-3UTR | ENST00000550722 | ENST00000542496 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| Frame-shift | ENST00000377560 | ENST00000281938 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| Frame-shift | ENST00000550722 | ENST00000281938 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| In-frame | ENST00000430131 | ENST00000281938 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| intron-3CDS | ENST00000549141 | ENST00000281938 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| intron-3UTR | ENST00000549141 | ENST00000542496 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000430131 | HECTD4 | chr12 | 112628590 | - | ENST00000281938 | HSPB8 | chr12 | 119624830 | + | 10464 | 9352 | 51 | 9575 | 3174 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000430131 | ENST00000281938 | HECTD4 | chr12 | 112628590 | - | HSPB8 | chr12 | 119624830 | + | 0.001750627 | 0.9982494 |
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Fusion Genomic Features for HECTD4-HSPB8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| HECTD4 | chr12 | 112628589 | - | HSPB8 | chr12 | 119624829 | + | 1.66E-05 | 0.99998343 |
| HECTD4 | chr12 | 112628589 | - | HSPB8 | chr12 | 119624829 | + | 1.66E-05 | 0.99998343 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HECTD4-HSPB8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112628590/chr12:119624830) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HECTD4 | HSPB8 |
| FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. | FUNCTION: Displays temperature-dependent chaperone activity. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HECTD4 | chr12:112628590 | chr12:119624830 | ENST00000430131 | - | 59 | 75 | 282_302 | 2735 | 3997.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HECTD4 | chr12:112628590 | chr12:119624830 | ENST00000430131 | - | 59 | 75 | 2867_2909 | 2735 | 3997.0 | Compositional bias | Note=Ser-rich |
| Hgene | HECTD4 | chr12:112628590 | chr12:119624830 | ENST00000430131 | - | 59 | 75 | 3627_3996 | 2735 | 3997.0 | Domain | HECT |
| Tgene | HSPB8 | chr12:112628590 | chr12:119624830 | ENST00000281938 | 0 | 3 | 74_185 | 122 | 197.0 | Domain | sHSP |
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Fusion Gene Sequence for HECTD4-HSPB8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >36036_36036_1_HECTD4-HSPB8_HECTD4_chr12_112628590_ENST00000430131_HSPB8_chr12_119624830_ENST00000281938_length(transcript)=10464nt_BP=9352nt GCGGCCGCTGACTCGGCGCAGTGGCTCTCGGTGAAGGAAGAGACCATCTTCCTGCACGACGGGCTGATCCGGGTCACCGACCTGGCCGAG CTGCCCAGCGAGATCCTCGGGGCCCCAGAGGCCGCGGACACCGACCTGGAGATTTTAACCTTTGAGACCAAGAACCCGTCGGAATTAGCA GAACGTTTGCGCTCTGTTTGTGGGAATCAGAGCAATGCCTATGCCCGGCTGCTGGAATACCGCCTGAATGCCTTGCGAGGACTGTGGAAT GCCCAGCGCCAGCTGGCCTTAGAAGAACAGCATGAAAGGGAAAGTTCAGGTGATGAGGAAACTTTGGCCCTGCTCAAACGCCAGGGCTTG TTGCAGCAACCTGAGCAAGCGCCCTTCACATCGAGGATGGGGCTCCTGCTGGTCTTCCCCCTTATTCAGTCCCAGAGTAGAACAGACCCC TCTCTCTGTAACATAACTGCTGAGGTGCTATTGAACTGCCTTCGTGACTGCCAGCCTTTGAGCTTGACCAAGGAGCCTGCTGACTGTCTC AATGGAATTGAAACTTTGCTGTGCTCTTGGCTAGAGGAGACTTCTGACACAGGCCGACACATCCCACATAAGCAAAAAGAAAATGCTGCT GCTGCCCTGGTGGCTTTGGCTTGTGCCAGGGGATCATTGAAAACTTTCGTCCACACAGTCCATCTATTACAGAAACAGACGGATCTAGGG TCCCTGCCTGTAGCTGATGTGCTATATAGGCTGTTGCTTTTGGAAGGGGGGCCTGGATCTCCCTCCTGTTTGCTTGGGGGCAAACACATA GTATCATGGGGTTATGAAGACATGTTGCCTGCGCCGGATAGCAACACTGGCTCCAGTTCTGAAAATAAAGATGCTGACTTGGGACGCTGT CTCACGGCAGATGGTCTTTACCTGTATACTACTAACTCAGTTGGAAGAGGAGTAAGCAAATTGGGATCTGGATTACATGGTACTCTCAGA GGTTTTGTGTACTGCCGGAACGAGGAGTTGGAACCAGGATGGGTGGCTTTTGGCAGCGGCAGTCTTCTCCACCGGCCTGTCTCTTTCGAT AATAAACCTCACTCCCTTTTCCAGGTCATTGACCAGAACACCCTTCAGGTGTGCCAGGTGGTGCCAATGCCAGCCAATCACCTCCCCATT GGCAGCACCATGAGCACTGTGCACCTGTCTTCAGATGGCACTTACTTCTATTGGATCTGGTCTCCTGCCAGCCTGAATGAGAAAACACCG AAGGGACATTCTGTCTTCATGGACATTTTTGAACTTGTGGTTGAAAATGGTGTATTTGTAGCCAACCCACTTCAGGAACGTACAATTCTA ATGAGAAAAGAGGGCGAATCTGCCAAAAGCATTAATGAGATGCTTCTAAGTAGACTTTCTCGGTATAGAGCCTCCCCGTCAGCAACGCTT GCTGCCCTGACTGGTTCCACCATCTCCAACACACTGAAAGAGGATCAAGCAGCAAATACTAGCTGTGGGCTGCCTCTAAAAATGCTGCGG AAGACACCCATATATACCTGTGGCACCTACTTGGTGATGCTGGTGCCTCCTCCAGGGGGATCAGGCAGCTCTGCCACCCGATCTCTTTTT GGTGGAACAAGTGGTTTGTCATCTTTAAAAAGAGCGTGTTATGACACAGTGAACAACATGCTATGGACATGCTCAAATGACTATATCGAT CAGTGGTGTAACCCTGGGAATCAAGCCTTCCATTATGTCTGCCAGAGACTTGGAGTCAGTCACATTATCACTGAGCCCAAAGAAGAGGCT ATAACCACGAATGAGGTTATAAACCAATTATTGCACCACGTTGGTGCGATGTGCATACACCAACTCAATCTTCTTGCCACCAACCCCAAT CTTCCAATCACAAGTGTCTTGGGCAAGCAGCATCCAATTGAAGCACATCATCTTAGCAGTATTTGTGACATTATGGAGAAGGCCATGGTT AATGGAGATACCTGTATTATACGCTGCATTCTCGTTGTCTTTCAGGTGGTATTTAAATTTTTCTTCAGCCCACAAACTGAAAGGAATCGA GACATCATTCGACGGTCGGGATTGCTTCTTTGGCAGTTGTTGATGGCTCCAAAAGATCAAATTTGCCCTGAAATTCAGAAGGAAGTCTGC CTTGCCATCAGCTCTGGTTTAAATATCTTGTACCCAGGTGAAACTGAAATCAATAACTTACTTAAACTGGTCTTAACAGAAGGAGAGAGA AACAGTGGACTCTCCCAGCTACGGGATGTGATCCTAACCAACCTGGCTGAACAGCTCCAAAACAACCGATTTGGCAGTGATGAGGATGAT CATTACAGACTAAATGATGAACTTTTACACTACATTCTGAAGATTGTTGTACGAGAATCCTGTATCTTAATCACCAAGTGCCAAACTGTC TCTAAAGATGATTTTCAAAAGCTCCTTTCAACTGTGCCTGCTGCATCCTCCTGCCTGCGCTATCTGATGGCAGTTCAGAATCACCTTCTC AGTAACACTATTTTGATTAAACCTGATGAGAATGATGACAGTGACAGCTCCTTGCAGGGAGAGACATTGAAGGTACAGGAGCTAAAAGTC AGTATTTTGGCTCTTGCCACCCAAATCCTGACTGGATGTGATGAAGTGTTGGAAATGCTACAGCAGGTCACAACTGCCCTCATAAATAGT GACATAGCAGACCGTGAGCAGAGGTTAAAAGGCTTGGAACAAGTTACTAAGGCTACTATGCTTGGTCACCTTCTTCCAGTGTTACTGACC TCCTTGATGCATCCAAATTTACAGACTCTGATCATGGCGGATGCCCTGATGCCTCAGCTAGTGCAGCTGGTACTCTATACCAGCCAGACG GCGTTGCTGCTTAAAACCCAGTGTCCGGTTTTTGCTGAGGTGGGCTGTTCCCCGTGTGGTGCACCAGACCAGAAGTGCAGGCTGTTCCCT GATGAGAGAATGTTAGAAGAGAAGGAAGAGCCAGGATTTCTCACTGGTTTAAAGATTCCTGCCCCATGGGCTGCTGGAAAGACTGTGGAA ACAGTCCACCCCGTCAGAGACAACTATAAATTTAAAGAAACGGTCCATATCCCAGGAGCTCGCTGCCTGTACCTTAGATTTGATAGCAGA TGCTCTTCGCAATATGACTATGACAAATTGGTGATATATGCGGGGCCTAACACAAACAGTAGGAAGGTTGCTGAATATGGAGGCAACACA CTGGGATATGGCAGCCGTAGTGTCTTAGGAACTGGTTGGCCGAAAGACTTGGTGAAGTGCATTTCCCCCCCTTCCTTAAATTTTAAGGTG GAAGGAGATACAGTCACCTTCTCCTTTGAAATGAGAAGTGGCCGTGAACACAACACTCCTGATAAAGCCATGTGGGGCTTTGCTTGCACA GTTCGCGCTCAGGAGTCTTCGGAGGATGTCTCAGGAGGCTTGCCCTTTCTGGTAGACCTGGCTTTAGGTCTGTCTGTGTTAGCTTGTTCC ATGTTAAGAATCCTGTACAATGGACCAGAAATTACCAAAGAAGAAGAAGCCTGTCAGGAGCTATTGCGGTCCAAACTTTTACAAAGGTGC CAGTGGCAGGTGGAGGCCAATGGCGTGATCTCCCCTGCCCTTACTCCGAGCCCCTCTCCACTGCCTCTGACCATAGAGGAAGACAGAGAA TTCACCTACCCCTCTGATGTCCTCGTGCCTCCTGTTGGAAACTACTTTGATCTGCCTCGGATCAGACTGCCTCCAGGAATCATGATAAAG CTCAGGGAAATTTCTGGGCGTGCTAGACCTCAATTTAGACCAAGTATAAAAGAAGTGATTCAGCCAGACGTGATGGAGGAAATGGTGGTA TCTTGTGTTATTAAGCACTTGAACTTGGTTGATGCACTGCAGTCTCTAATAAATTTCCAATATCAAGAAGAACATGCTGAAGAATATGAT TTATTATGTAAAATTATGGGAGAGACCTTTAAGAAACTCAATGCCATGGAGAGACAGCTGCAGAGTGTTGCAGAACTGGAACAAAAATGG CAAAGTGAAGTTGATGATGCCATGCAGGGGAAACTGGAGAACAACATGCCTTTCTTTTATGATTACCATTTTAATGAGAACAAAATGAAA GAACTAGAACTTTTATGTTCAATGAAGGAAGTCTCCTTTGATGGGAATGATCTTGAAAACATGGTCCTATCACTGAGGGAGAAGTTCCTA CAAGAAGTGAATTCTCTTATTCAGAAACCCTCACACCCACTGGCTAAAACAAAGACGTTAGTGAAGAGTTTAATGAACCGAGCCGAGCTG TTGCTGCATGTCACCATCGCAGCCCAGTCGGGCCTCACGAGAAGCATCTCTGGGACCCCTGCTGAAACACCAGCTTGTAAATCAGCTTCT GAAACAAAAGTGATATCTCACGCTGTCAGGCAGCCTGTTTTTCTTCGCAGCATGTCAGCTCCTTCTGACCTGGAAATGATTGGTAATGAA GATTTGGAATTTACTAGAGCAAATCAGAGGCGTCGCCACGTGACCAGCCACCGCAGCAGCTCCTTTACACTCCTGCAGTCGCTGGCCATT GAGGACAGCAGGGACAAGCCCACCTACAGTGTCCTGCTAGGGCAGCTGTTTGCTTTCATCGGCACCAACCCTGACCAAGCTGTGTCCAGC AGCAGTTTCCTTTTGGCTGCACAGACAAGGTGGCGGCGGGGAAACACTCGCAAGCAGGCACTGGTGCACATGCGGGAATTGCTGACAGCT GCCGTACGAGTCGGGGGAGTGACGCATCTTGTGGGTCCAGTGACGATGGTCCTTCAGGGAGGACCCAGAATTGAAGAACTCACATGTGGT GGGATGGTCGAGCAGGTCCAGGAAGCCTTTGGCGAGACCATGACCTCTGTTGTGTCTCTGTGTGCTCGTTACCCTATCGCTTGCGCAAAT AGCATTGGACTCTTATGTACCATACCTTACACCAGGAGCGAAGAGAAGTGCCTGGTACGCAGTGGCCTTGTGCAGCTCATGGATCGACTG TGTAGCTTGAGCAATCAGACCGAGTCCAGCTCCAGTGAGAAACAGACCAAGAAGCAGAAGGTGGCCACCATGGCCTGGGCTGCCTTCCAG GTGCTTGCCAACCGCTGTGTTGAGTGGGAAAAAGAGGAAGGTGGCTCCACAGAGGCTGTGCACTCAGGTCTGGCCCGGCAGGTGTCCAGC CTTCTCACTAACCATCTTGCCCGAGCCACAGAGTGCTGTGGCAACCAGGCTGCTGGGAATGACGCGCTCCAGGATGTCCTTAGTCTTCTC AATGATCTCTCAAGGAGCCACATAGGTAAAGCCATCCTGAGCCAGCCAGCTTGTGTGTCCAAACTCCTCTCCCTGCTGCTTGACCAACGC CCGTCTCCAAAGCTAGTCCTTATTATTCTCCAGCTGTGCCGGGCGGCGCTGCCCCTGATGAGCGTAGAAGACTGTGGAAACGTGGAGCTC CCACCCTGGAGCTACTCTGTCCCCTCCTTAAACAGTGAGCAGGAGGATCCCAGCGACCCAGCTTCCAAGATCGCCTCCCTGCTCTTAGCA AAGCTGGCAGATTATGTGGTTCCAGGATGTCAGACAGTTCTTTCTCCAACCGCTTCTGAACCTGACACCACATTGACAAAAACCAGTCCC AAGAATTCCTTGAAAGGAGATAAAGATCCTGGAGAAGAGAGTGAGGCTGTGGATGGCAAGCTCTCGATATTTATCCACAAGCGGGAAGAC CAGTCATCCCATGAAGTCCTCCAGCCATTGCTAAGTAGTTCAGAAGGACGGCCCTTCCGACTTGGTACTGGCGCCAACATGGAGAAAGTT GTGAAGATGGATCGAGACATGACCAAGGGTGGCTGTTGCGAAGTGATTACAGAAGAGGCTGCAGCCGCCCTGCGGAAAGCCACCAAGTGG GCACAGTCAGGCCTCATCGTCAGCATTGGGCCACCTGTAGAGTCTATCAACCCAGAGACTGTGAGTGGACTATCCACAGGCGACAAAAAG AAAACTGCCCAAACTTCCATTTGCCGAGAGAGGAACTCGGAGCTTGCAAGGACTGATCCTGTGCGTCCCTTCATCAGTGGGCATGTGGCA AACAGCATGGCTGCAGAAGTGATCGCCTTGCTACATAGCTTGCTCATGGCACCTGAATCAAATGCTGCTCAAATATGGACCACAACAGCA GAGAAGGTTCTGTCTAGAGCACTGATGTACATTCCACAATTGGGGAAATACGCAGAAAGCATTCTGGAAAATGGCAGCAGCAGTGGCAGG AAACTTGCCAAACTTCAGAGAATTGCACGCCAGGCCGTTGCCGCACTGTGTGCACTTGGAGGCTTCAAAGAGACAATCAAGATAGGATCC GAGGTTCAGGTTTTAGGTAGAGGAATTTCAGGAAGCATTGGAGTAGTGGCTTCTATCAATGAACAGGAAGGTATAGCTACAGTCAGATTC CCACCCATAGACTGTAGAAAGACTTCGCAAGCGTCAGACACATTGACTATTCCATTGTCTAGACTTTGTGTTCCAAGATCAGAGGCATTG CCTCTTCATAAACTGTCCATTACTGAGAAGGTAGTACAGGCAGTCCAGTCCATGTTGCTTCCTCAGGAGGGAAGTCTCTCTATTCACACC TCACTTCCTGCAACAGGAGATGGGTCAGCTCCTGTGATGGCAGTCGTTCGGCTCCTTGCTGAAATAAGGACAAGAGCATGCCTGGTCATG GCCCAGCTTTTAGAAGACAGCTTATTTTGTGAAGAATTCATACAACAATGTCCAGCAGCTGTTGAAGTTCTTAACCTAGTAGCCCAGGAA TGTAGTGCTGGAGAGCGACTTGCAGTTGTGGAGGTACAGTGTGAACGGCTGAGGATGCTCTACCGGGACTGTGCTCGGCCCCCACCACCT CCTTTGCAGGCTGACCGAAGACAGCCCAAAGAGATTACTTGGAGCCCCTCGCGAGTGTTTCCGCCTGTTCGAGCCTGCATGTTCTCATCT CACCTTACCTCAGTCACCTTCCTGGCTGACCCCAGCGCTGGGGGAGGCCTGCCCCGGGGCACTTTTATCTATGCCACTTCACCACTGCCA GTTCAGGCCCCGTCTTTTTACTGGGAAATTGAAATCGTTTCCTATGGAGACACCGATGATGACACCGGACCCATAGTTTCCTTTGGCTTC ACTACAGAAGCAGAGAAGCGAGATGGGGCTTGGACTAATCCAGTGGGCACTTGTCTTTTCCATAACAACGGCCGAGCCGTGCACTATAAT GGCTCCAGTTTGTTACAGTGGAAGAGCGTTCGCTTAGACGTGACTCTCTCCCCCGGTGACGTGGCAGGAATTGGCTGGGAGAGAACTGAG GGGACTCCACCTCCTCCGGGACAGCCAGCCAAGGGCCGGGTGTACTTCACATACTGCGGGCAGCGCCTCTCACCATATCTTGAAGACGTC TCTGGTGGCATGTGGCCAGTGGTTCACATTCAGAAAAAGAACACCAAAACCCGAGCTAACTTTGGCTCCCGGCCGTTTGCCTACGCGGAA GGGCAGGCCCACCGCAATGCTGCTGACCTGTGCACTGACCTAGCAGAAGAGATCAGCGCTAACTTTGAGGCCCTGCCTTTCGCCATGGCA TCTGACAGTGACAATGATGCTGGCACCAGTATTGCATCAGACCCAGGCACTCATGGGCCACCATGCCGGATTGCTGCCGTGGCCACCGCT CAGCAACAATATGATAGTGACACCTCCTGTCATTATAAAGTCGAGCTCAGCTATGAGAATTTCATCACCTCTGGCCCAGACCCTCACCCG CCTCCCATTGCAGATGATGAAAGCGATGATGATGACGATGATGACATCCCTCAGGAGGACCACTACGCCCTGCTGGTGAAAGCATGGGAG ACCAAGGTTTTTCCTACCATCCGAAGACGCTTCCGCAATGAAGCAGAGCGGAAATCGGGCCTGGACCAGATAAAGGGGGCCTTACAACTA GGTATGGTGGATATTGCCCGACAGACGGTTGAATTTCTCTACGAAGAGAATGGTGGCATCCCAAGAGACCTTTATCTTCCCACCATTGAA GACATTAAAGACGAAGCAAACAAGTTCACAATTGATAAAGTTCGAAAAGGTCTCACAGTAGTAACCCGCTCTCCAGACAGCAATAATGTA GCCAGCAGTGCTGTTGGAACTGCTCTGCCAAAATTTGCCATCCGAGGGATGCTGAAAACCTTTGGGCTTCATGGAGTCGTCTTAGATGTT GATTCAGTGAATGAACTGGTGCAGGTAGAAACGTACCTCCGCAGTGAAGGTGTGCTGGTGCGATACTGGTATCCTATTGACATGTTGGAA AGGCCCCCAGCAGGCTACCGAAGGACTGCCACCAATGGGCTGGTCACACTGGACAATACCAACCTTCAAATTCACAGGGAGCTGCTGCGC TGCGAGGCTGCGCTGGCCAGGCTGTACTGCCGCATGGCCCTGCTCAATATCTTCGCCCCGAAGTTGCCTCACTTGTTCACTCGCCTCTTC CACATCCCTGCCATCCGGGACATTACCCTGGAGCACCTGCAACTGCTGTCCAATCAGCTCCTCGCACCTCCTCTCCCAGACGGCACCATC AGCTCCAGCTCGATCCTCCTGGCGCAGTCTTTACAGCATTGCATCCATTCCCAGAACTGCTCCGCCACGGACCTCTTTTACCAGGGCAAC TCCCAGACAGTGAGAGAGTGGCTCAACGTGGCCATCACCCGGACCCTGCACCAGGGCGAGGAGAGCCTTTTAGAGCTGACGAAACAGATC TGCTCTTTCCTGCAGACAGCACCAGAGCAGTTCCCCTCCGAAGAGTTCCCAATTTCCGAATCCAAAGTCAACATGGACGTGAATTTCCCC GGGGCAGCTTTTGTTGTTGTGTCTTGTAAAGAAAGTCAATCTGGATTCCGCAAAGACTCCTCTCTGTACAAGGCACCGTGGGCACGGGTG CTCGTATATGGCCTCGGCCACAAAGTGAAGCGAAATGGCCAGCTGAACCTCATCGAGGCCGCCTGTTACCCGCGGGACGCGTCCCCAGCC AACACTGGGCTTGCACCTCCCCCCACCGCTGACCAGTACCCCTCTGTGGTCCTCTCCACAGACAGGGTCCACATCAAACTGGGGGTGTCT CCACCTCCTGGAGCAGTCCTGGTGTTACATTCCCTGCCCCTGGAGTTCCCACTGGCTATGGCCTTCGCAGAGCAGCTGCTGTCCTGGAAA TCAGAGGACAGTGAAGGGAAGTCCGAAGATGAGCCTGACACCATTCCGACATCCGTCCTCCTGCAGGTGGTGGAGCTGCTAGGCAAACAT GAAGAGAAACAGCAAGAAGGTGGCATTGTTTCTAAGAACTTCACAAAGAAAATCCAGCTTCCTGCAGAGGTGGATCCTGTGACAGTATTT GCCTCACTTTCCCCAGAGGGTCTGCTGATCATCGAAGCTCCCCAGGTCCCTCCTTACTCAACATTTGGAGAGAGCAGTTTCAACAACGAG CTTCCCCAGGACAGCCAGGAAGTCACCTGTACCTGAGATGCCAGTACTGGCCCATCCTTGTTTTGTCCCCAACCCTAGGGCTTCTCTGAT TCCAGGATACATTACTTTAGCTGAACTCAGATTTAGTGCAAGTAAAATGTTAGAGGGTGCGGGGGTGAGGACTGACCACAGATTCCCTGG ATAGTGTAGTGGTAGATTTCTCCACAGGATAGCGCAATTGGCAAATCATGCTTGGTTGTGTTAGGCCAAAATACTAGTTTTGCTTTCTTT ACCTTTTCTATCTTGATGAAAATGTTGCACATTCTATAGTTGCAAAACACATAAAAGGGGACTTAACATTTCACGTTGTATCTTACTTGC AGTGAATGCAAGGGTTACTTTTCTCTGGGGACCTCCCCCATCACCCAGGTTCCTACTCTGGGCTCCCGATTCCCATGGCTCCCAAACCAT GCCGCATGGTTTGGTTAATGAAACCCAGTAGCTAACCCCACTGTGCTTCCACATGCCTGGCCTAAAATGGGTGATATACAGGTCTTATAT CCCCATATGGAATTTATCCATCAACCACATAAAAACAAACAGTGCCTTCTGCCCTCTGCCCAGATGTGTCCAGCACGTTCTCAAAGTTTC CACATTAGCACTCCCTAAGGACGCTGGGAGCCTGTCAGTTTATGATCTGACCTAGGTCCCCCCTTTCTTCTGTCCCCTGTGTTTAAGTCG GGATTTTTACAGAGGGAGCTGTCTCCAGACAGCTCCATCAGGAACCAAGCAAAGGCCAGATAGCCTGACAGATAGGCTAGTGGTATTGTG TATATGGGCGGGACGTGTGTGTCATTATTATTTGAGTTATGCTGTTGTTTAGGGGTAAATAACAGTAAATAATTAATAATAATAATAATA >36036_36036_1_HECTD4-HSPB8_HECTD4_chr12_112628590_ENST00000430131_HSPB8_chr12_119624830_ENST00000281938_length(amino acids)=3174AA_BP=3098 MHDGLIRVTDLAELPSEILGAPEAADTDLEILTFETKNPSELAERLRSVCGNQSNAYARLLEYRLNALRGLWNAQRQLALEEQHERESSG DEETLALLKRQGLLQQPEQAPFTSRMGLLLVFPLIQSQSRTDPSLCNITAEVLLNCLRDCQPLSLTKEPADCLNGIETLLCSWLEETSDT GRHIPHKQKENAAAALVALACARGSLKTFVHTVHLLQKQTDLGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIVSWGYEDMLPAPDSNTG SSSENKDADLGRCLTADGLYLYTTNSVGRGVSKLGSGLHGTLRGFVYCRNEELEPGWVAFGSGSLLHRPVSFDNKPHSLFQVIDQNTLQV CQVVPMPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKSINEMLLS RLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKRACYDTV NNMLWTCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQLLHHVGAMCIHQLNLLATNPNLPITSVLGKQHPIEAHH LSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFFSPQTERNRDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEI NNLLKLVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCILITKCQTVSKDDFQKLLSTVPAASS CLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGETLKVQELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTK ATMLGHLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAPDQKCRLFPDERMLEEKEEPGFLTGL KIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARCLYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDL VKCISPPSLNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALGLSVLACSMLRILYNGPEITKEEEA CQELLRSKLLQRCQWQVEANGVISPALTPSPSPLPLTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIK EVIQPDVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQSVAELEQKWQSEVDDAMQGKLENNMP FFYDYHFNENKMKELELLCSMKEVSFDGNDLENMVLSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLTRSIS GTPAETPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSSFTLLQSLAIEDSRDKPTYSVLLGQLF AFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTSV VSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKVATMAWAAFQVLANRCVEWEKEEGGST EAVHSGLARQVSSLLTNHLARATECCGNQAAGNDALQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRAAL PLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPDTTLTKTSPKNSLKGDKDPGEESEAV DGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGGCCEVITEEAAAALRKATKWAQSGLIVSIGPPVESIN PETVSGLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKY AESILENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINEQEGIATVRFPPIDCRKTSQASDTLTI PLSRLCVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEIRTRACLVMAQLLEDSLFCEEFIQQC PAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGL PRGTFIYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSLLQWKSVRLDVTLS PGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEE ISANFEALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFITSGPDPHPPPIADDESDDDDDDDIP QEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLDQIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKG LTVVTRSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRYWYPIDMLERPPAGYRRTATNGLVTL DNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHS QNCSATDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISESKVNMDVNFPGAAFVVVSCKESQSGFR KDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAACYPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFP LAMAFAEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HECTD4-HSPB8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HECTD4-HSPB8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HECTD4-HSPB8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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