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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HECTD4-SRRM4 (FusionGDB2 ID:36048) |
Fusion Gene Summary for HECTD4-SRRM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HECTD4-SRRM4 | Fusion gene ID: 36048 | Hgene | Tgene | Gene symbol | HECTD4 | SRRM4 | Gene ID | 283450 | 84530 |
| Gene name | HECT domain E3 ubiquitin protein ligase 4 | serine/arginine repetitive matrix 4 | |
| Synonyms | C12ord51|C12orf51|HEEL|POTAGE | KIAA1853|MU-MB-2.76|nSR100 | |
| Cytomap | 12q24.13 | 12q24.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable E3 ubiquitin-protein ligase HECTD4AF-1 specific protein phosphataseHECT domain containing E3 ubiquitin protein ligase 4HECT domain-containing protein 4HECT-type E3 ubiquitin transferase HECTD4probable E3 ubiquitin-protein ligase C12orf51tra | serine/arginine repetitive matrix protein 4medulloblastoma antigen MU-MB-2.76neural-specific SR-related protein of 100 kDaneural-specific serine/arginine repetitive splicing factor of 100 kDa | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y4D8 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000377560, ENST00000430131, ENST00000550722, ENST00000549141, | ENST00000537597, ENST00000267260, | |
| Fusion gene scores | * DoF score | 22 X 15 X 10=3300 | 5 X 6 X 4=120 |
| # samples | 20 | 5 | |
| ** MAII score | log2(20/3300*10)=-4.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HECTD4 [Title/Abstract] AND SRRM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HECTD4(112605121)-SRRM4(119554742), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | HECTD4-SRRM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRRM4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 29961578 |
| Fusion gene breakpoints across HECTD4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SRRM4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-C8-A12M-01A | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
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Fusion Gene ORF analysis for HECTD4-SRRM4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000377560 | ENST00000537597 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| 5CDS-intron | ENST00000430131 | ENST00000537597 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| 5CDS-intron | ENST00000550722 | ENST00000537597 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| Frame-shift | ENST00000430131 | ENST00000267260 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| In-frame | ENST00000377560 | ENST00000267260 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| In-frame | ENST00000550722 | ENST00000267260 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| intron-3CDS | ENST00000549141 | ENST00000267260 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| intron-intron | ENST00000549141 | ENST00000537597 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000377560 | HECTD4 | chr12 | 112605121 | - | ENST00000267260 | SRRM4 | chr12 | 119554742 | + | 20138 | 12414 | 51 | 12428 | 4125 |
| ENST00000550722 | HECTD4 | chr12 | 112605121 | - | ENST00000267260 | SRRM4 | chr12 | 119554742 | + | 20216 | 12492 | 51 | 12506 | 4151 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000377560 | ENST00000267260 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + | 0.001177768 | 0.9988223 |
| ENST00000550722 | ENST00000267260 | HECTD4 | chr12 | 112605121 | - | SRRM4 | chr12 | 119554742 | + | 0.001179914 | 0.99882 |
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Fusion Genomic Features for HECTD4-SRRM4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| HECTD4 | chr12 | 112605120 | - | SRRM4 | chr12 | 119554741 | + | 0.000143114 | 0.9998568 |
| HECTD4 | chr12 | 112605120 | - | SRRM4 | chr12 | 119554741 | + | 0.000143114 | 0.9998568 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HECTD4-SRRM4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112605121/chr12:119554742) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HECTD4 | . |
| FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HECTD4 | chr12:112605121 | chr12:119554742 | ENST00000430131 | - | 71 | 75 | 2867_2909 | 3756 | 3997.0 | Compositional bias | Note=Ser-rich |
| Hgene | HECTD4 | chr12:112605121 | chr12:119554742 | ENST00000430131 | - | 71 | 75 | 282_302 | 3756 | 3997.0 | Transmembrane | Helical |
| Tgene | SRRM4 | chr12:112605121 | chr12:119554742 | ENST00000267260 | 2 | 13 | 123_608 | 121 | 612.0 | Compositional bias | Note=Ser-rich | |
| Tgene | SRRM4 | chr12:112605121 | chr12:119554742 | ENST00000267260 | 2 | 13 | 442_598 | 121 | 612.0 | Compositional bias | Note=Arg-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HECTD4 | chr12:112605121 | chr12:119554742 | ENST00000430131 | - | 71 | 75 | 3627_3996 | 3756 | 3997.0 | Domain | HECT |
| Tgene | SRRM4 | chr12:112605121 | chr12:119554742 | ENST00000267260 | 2 | 13 | 109_171 | 121 | 612.0 | Compositional bias | Note=Lys-rich |
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Fusion Gene Sequence for HECTD4-SRRM4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >36048_36048_1_HECTD4-SRRM4_HECTD4_chr12_112605121_ENST00000377560_SRRM4_chr12_119554742_ENST00000267260_length(transcript)=20138nt_BP=12414nt GCGGCCGCTGACTCGGCGCAGTGGCTCTCGGTGAAGGAAGAGACCATCTTCCTGCACGACGGGCTGATCCGGGTCACCGACCTGGCCGAG CTGCCCAGCGAGATCCTCGGGGCCCCAGAGGCCGCGGACACCGACCTGGAGATTTTAACCTTTGAGACCAAGAACCCGTCGGAATTAGCA GAACGTTTGCGCTCTGTTTGTGGGAATCAGAGCAATGCCTATGCCCGGCTGCTGGAATACCGCCTGAATGCCTTGCGAGGACTGTGGAAT GCCCAGCGCCAGCTGGCCTTAGAAGAACAGCATGAAAGGGAAAGTTCAGGTGATGAGGAAACTTTGGCCCTGCTCAAACGCCAGGGCTTG TTGCAGCAACCTGAGCAAGCGCCCTTCACATCGAGGATGGGGCTCCTGCTGGTCTTCCCCCTTATTCAGTCCCAGAGTAGAACAGACCCC TCTCTCTGTAACATAACTGCTGAGGTGCTATTGAACTGCCTTCGTGACTGCCAGCCTTTGAGCTTGACCAAGGAGCCTGCTGACTGTCTC AATGGAATTGAAACTTTGCTGTGCTCTTGGCTAGAGGAGACTTCTGACACAGGCCGACACATCCCACATAAGCAAAAAGAAAATGCTGCT GCTGCCCTGGTGGCTTTGGCTTGTGCCAGGGGATCATTGAAAACTTTCGTCCACACAGTCCATCTATTACAGAAACAGACGGATCTAGGG TCCCTGCCTGTAGCTGATGTGCTATATAGGCTGTTGCTTTTGGAAGGGGGGCCTGGATCTCCCTCCTGTTTGCTTGGGGGCAAACACATA GTATCATGGGGTTATGAAGACATGTTGCCTGCGCCGGATAGCAACACTGGCTCCAGTTCTGAAAATAAAGATGCTGACTTGGGACGCTGT CTCACGGCAGATGGTCTTTACCTGTATACTACTAACTCAGTTGGAAGAGGAGTAAGCAAATTGGGATCTGGATTACATGGTACTCTCAGA GGTTTTGTGTACTGCCGGAACGAGGAGTTGGAACCAGGATGGGTGGCTTTTGGCAGCGGCAGTCTTCTCCACCGGCCTGTCTCTTTCGAT AATAAACCTCACTCCCTTTTCCAGGTCATTGACCAGAACACCCTTCAGGTGTGCCAGGTGGTGCCAATGCCAGCCAATCACCTCCCCATT GGCAGCACCATGAGCACTGTGCACCTGTCTTCAGATGGCACTTACTTCTATTGGATCTGGTCTCCTGCCAGCCTGAATGAGAAAACACCG AAGGGACATTCTGTCTTCATGGACATTTTTGAACTTGTGGTTGAAAATGGTGTATTTGTAGCCAACCCACTTCAGGAACGTACAATTCTA ATGAGAAAAGAGGGCGAATCTGCCAAAAGCATTAATGAGATGCTTCTAAGTAGACTTTCTCGGTATAGAGCCTCCCCGTCAGCAACGCTT GCTGCCCTGACTGGTTCCACCATCTCCAACACACTGAAAGAGGATCAAGCAGCAAATACTAGCTGTGGGCTGCCTCTAAAAATGCTGCGG AAGACACCCATATATACCTGTGGCACCTACTTGGTGATGCTGGTGCCTCCTCCAGGGGGATCAGGCAGCTCTGCCACCCGATCTCTTTTT GGTGGAACAAGTGGTTTGTCATCTTTAAAAAGAGCGTGTTATGACACAGTGAACAACATGCTATGGACATGCTCAAATGACTATATCGAT CAGTGGTGTAACCCTGGGAATCAAGCCTTCCATTATGTCTGCCAGAGACTTGGAGTCAGTCACATTATCACTGAGCCCAAAGAAGAGGCT ATAACCACGAATGAGGTTATAAACCAATTATTGCACCACGTTGGTGCGATGTGCATACACCAACTCAATCTTCTTGCCACCAACCCCAAT CTTCCAATCACAAGTGTCTTGGGCAAGCAGCATCCAATTGAAGCACATCATCTTAGCAGTATTTGTGACATTATGGAGAAGGCCATGGTT AATGGAGATACCTGTATTATACGCTGCATTCTCGTTGTCTTTCAGGTGGTATTTAAATTTTTCTTCAGCCCACAAACTGAAAGGAATCGA GACATCATTCGACGGTCGGGATTGCTTCTTTGGCAGTTGTTGATGGCTCCAAAAGATCAAATTTGCCCTGAAATTCAGAAGGAAGTCTGC CTTGCCATCAGCTCTGGTTTAAATATCTTGTACCCAGGTGAAACTGAAATCAATAACTTACTTAAACTGGTCTTAACAGAAGGAGAGAGA AACAGTGGACTCTCCCAGCTACGGGATGTGATCCTAACCAACCTGGCTGAACAGCTCCAAAACAACCGATTTGGCAGTGATGAGGATGAT CATTACAGACTAAATGATGAACTTTTACACTACATTCTGAAGATTGTTGTACGAGAATCCTGTATCTTAATCACCAAGTGCCAAACTGTC TCTAAAGATGATTTTCAAAAGCTCCTTTCAACTGTGCCTGCTGCATCCTCCTGCCTGCGCTATCTGATGGCAGTTCAGAATCACCTTCTC AGTAACACTATTTTGATTAAACCTGATGAGAATGATGACAGTGACAGCTCCTTGCAGGGAGAGACATTGAAGGTACAGGAGCTAAAAGTC AGTATTTTGGCTCTTGCCACCCAAATCCTGACTGGATGTGATGAAGTGTTGGAAATGCTACAGCAGGTCACAACTGCCCTCATAAATAGT GACATAGCAGACCGTGAGCAGAGGTTAAAAGGCTTGGAACAAGTTACTAAGGCTACTATGCTTGGTCACCTTCTTCCAGTGTTACTGACC TCCTTGATGCATCCAAATTTACAGACTCTGATCATGGCGGATGCCCTGATGCCTCAGCTAGTGCAGCTGGTACTCTATACCAGCCAGACG GCGTTGCTGCTTAAAACCCAGTGTCCGGTTTTTGCTGAGGTGGGCTGTTCCCCGTGTGGTGCACCAGACCAGAAGTGCAGGCTGTTCCCT GATGAGAGAATGTTAGAAGAGAAGGAAGAGCCAGGATTTCTCACTGGTTTAAAGATTCCTGCCCCATGGGCTGCTGGAAAGACTGTGGAA ACAGTCCACCCCGTCAGAGACAACTATAAATTTAAAGAAACGGTCCATATCCCAGGAGCTCGCTGCCTGTACCTTAGATTTGATAGCAGA TGCTCTTCGCAATATGACTATGACAAATTGGTGATATATGCGGGGCCTAACACAAACAGTAGGAAGGTTGCTGAATATGGAGGCAACACA CTGGGATATGGCAGCCGTAGTGTCTTAGGAACTGGTTGGCCGAAAGACTTGGTGAAGTGCATTTCCCCCCCTTCCTTAAATTTTAAGGTG GAAGGAGATACAGTCACCTTCTCCTTTGAAATGAGAAGTGGCCGTGAACACAACACTCCTGATAAAGCCATGTGGGGCTTTGCTTGCACA GTTCGCGCTCAGGAGTCTTCGGAGGATGTCTCAGGAGGCTTGCCCTTTCTGGTAGACCTGGCTTTAGGTCTGTCTGTGTTAGCTTGTTCC ATGTTAAGAATCCTGTACAATGGACCAGAAATTACCAAAGAAGAAGAAGCCTGTCAGGAGCTATTGCGGTCCAAACTTTTACAAAGGTGC CAGTGGCAGGTGGAGGCCAATGGCGTGATCTCCCCTGCCCTTACTCCGAGCCCCTCTCCACTGCCTCTGACCATAGAGGAAGACAGAGAA TTCACCTACCCCTCTGATGTCCTCGTGCCTCCTGTTGGAAACTACTTTGATCTGCCTCGGATCAGACTGCCTCCAGGAATCATGATAAAG CTCAGGGAAATTTCTGGGCGTGCTAGACCTCAATTTAGACCAAGTATAAAAGAAGTGATTCAGCCAGACGTGATGGAGGAAATGGTGGTA TCTTGTGTTATTAAGCACTTGAACTTGGTTGATGCACTGCAGTCTCTAATAAATTTCCAATATCAAGAAGAACATGCTGAAGAATATGAT TTATTATGTAAAATTATGGGAGAGACCTTTAAGAAACTCAATGCCATGGAGAGACAGCTGCAGAGTGTTGCAGAACTGGAACAAAAATGG CAAAGTGAAGTTGATGATGCCATGCAGGGGAAACTGGAGAACAACATGCCTTTCTTTTATGATTACCATTTTAATGAGAACAAAATGAAA GAACTAGAACTTTTATGTTCAATGAAGGAAGTCTCCTTTGATGGGAATGATCTTGAAAACATGGTCCTATCACTGAGGGAGAAGTTCCTA CAAGAAGTGAATTCTCTTATTCAGAAACCCTCACACCCACTGGCTAAAACAAAGACGTTAGTGAAGAGTTTAATGAACCGAGCCGAGCTG TTGCTGCATGTCACCATCGCAGCCCAGTCGGGCCTCACGAGAAGCATCTCTGGGACCCCTGCTGAAACACCAGCTTGTAAATCAGCTTCT GAAACAAAAGTGATATCTCACGCTGTCAGGCAGCCTGTTTTTCTTCGCAGCATGTCAGCTCCTTCTGACCTGGAAATGATTGGTAATGAA GATTTGGAATTTACTAGAGCAAATCAGAGGCGTCGCCACGTGACCAGCCACCGCAGCAGCTCCTTTACACTCCTGCAGTCGCTGGCCATT GAGGACAGCAGGGACAAGCCCACCTACAGTGTCCTGCTAGGGCAGCTGTTTGCTTTCATCGGCACCAACCCTGACCAAGCTGTGTCCAGC AGCAGTTTCCTTTTGGCTGCACAGACAAGGTGGCGGCGGGGAAACACTCGCAAGCAGGCACTGGTGCACATGCGGGAATTGCTGACAGCT GCCGTACGAGTCGGGGGAGTGACGCATCTTGTGGGTCCAGTGACGATGGTCCTTCAGGGAGGACCCAGAATTGAAGAACTCACATGTGGT GGGATGGTCGAGCAGGTCCAGGAAGCCTTTGGCGAGACCATGACCTCTGTTGTGTCTCTGTGTGCTCGTTACCCTATCGCTTGCGCAAAT AGCATTGGACTCTTATGTACCATACCTTACACCAGGAGCGAAGAGAAGTGCCTGGTACGCAGTGGCCTTGTGCAGCTCATGGATCGACTG TGTAGCTTGAGCAATCAGACCGAGTCCAGCTCCAGTGAGAAACAGACCAAGAAGCAGAAGGTGGCCACCATGGCCTGGGCTGCCTTCCAG GTGCTTGCCAACCGCTGTGTTGAGTGGGAAAAAGAGGAAGGTGGCTCCACAGAGGCTGTGCACTCAGGTCTGGCCCGGCAGGTGTCCAGC CTTCTCACTAACCATCTTGCCCGAGCCACAGAGTGCTGTGGCAACCAGGCTGCTGGGAATGACGCGCTCCAGGATGTCCTTAGTCTTCTC AATGATCTCTCAAGGAGCCACATAGGTAAAGCCATCCTGAGCCAGCCAGCTTGTGTGTCCAAACTCCTCTCCCTGCTGCTTGACCAACGC CCGTCTCCAAAGCTAGTCCTTATTATTCTCCAGCTGTGCCGGGCGGCGCTGCCCCTGATGAGCGTAGAAGACTGTGGAAACGTGGAGCTC CCACCCTGGAGCTACTCTGTCCCCTCCTTAAACAGTGAGCAGGAGGATCCCAGCGACCCAGCTTCCAAGATCGCCTCCCTGCTCTTAGCA AAGCTGGCAGATTATGTGGTTCCAGGATGTCAGACAGTTCTTTCTCCAACCGCTTCTGAACCTGACACCACATTGACAAAAACCAGTCCC AAGAATTCCTTGAAAGGAGATAAAGATCCTGGAGAAGAGAGTGAGGCTGTGGATGGCAAGCTCTCGATATTTATCCACAAGCGGGAAGAC CAGTCATCCCATGAAGTCCTCCAGCCATTGCTAAGTAGTTCAGAAGGACGGCCCTTCCGACTTGGTACTGGCGCCAACATGGAGAAAGTT GTGAAGATGGATCGAGACATGACCAAGGGTGGCTGTTGCGAAGTGATTACAGAAGAGGCTGCAGCCGCCCTGCGGAAAGCCACCAAGTGG GCACAGTCAGGCCTCATCGTCAGCATTGGGCCACCTGTAGAGTCTATCAACCCAGAGACTGTGAGTGGACTATCCACAGGCGACAAAAAG AAAACTGCCCAAACTTCCATTTGCCGAGAGAGGAACTCGGAGCTTGCAAGGACTGATCCTGTGCGTCCCTTCATCAGTGGGCATGTGGCA AACAGCATGGCTGCAGAAGTGATCGCCTTGCTACATAGCTTGCTCATGGCACCTGAATCAAATGCTGCTCAAATATGGACCACAACAGCA GAGAAGGTTCTGTCTAGAGCACTGATGTACATTCCACAATTGGGGAAATACGCAGAAAGCATTCTGGAAAATGGCAGCAGCAGTGGCAGG AAACTTGCCAAACTTCAGAGAATTGCACGCCAGGCCGTTGCCGCACTGTGTGCACTTGGAGGCTTCAAAGAGACAATCAAGATAGGATCC GAGGTTCAGGTTTTAGGTAGAGGAATTTCAGGAAGCATTGGAGTAGTGGCTTCTATCAATGAACAGGAAGGTATAGCTACAGTCAGATTC CCACCCATAGACTGTAGAAAGACTTCGCAAGCGTCAGACACATTGACTATTCCATTGTCTAGACTTTGTGTTCCAAGATCAGAGGCATTG CCTCTTCATAAACTGTCCATTACTGAGAAGGTAGTACAGGCAGTCCAGTCCATGTTGCTTCCTCAGGAGGGAAGTCTCTCTATTCACACC TCACTTCCTGCAACAGGAGATGGGTCAGCTCCTGTGATGGCAGTCGTTCGGCTCCTTGCTGAAATAAGGACAAGAGCATGCCTGGTCATG GCCCAGCTTTTAGAAGACAGCTTATTTTGTGAAGAATTCATACAACAATGTCCAGCAGCTGTTGAAGTTCTTAACCTAGTAGCCCAGGAA TGTAGTGCTGGAGAGCGACTTGCAGTTGTGGAGGTACAGTGTGAACGGCTGAGGATGCTCTACCGGGACTGTGCTCGGCCCCCACCACCT CCTTTGCAGGCTGACCGAAGACAGCCCAAAGAGATTACTTGGAGCCCCTCGCGAGTGTTTCCGCCTGTTCGAGCCTGCATGTTCTCATCT CACCTTACCTCAGTCACCTTCCTGGCTGACCCCAGCGCTGGGGGAGGCCTGCCCCGGGGCACTTTTATCTATGCCACTTCACCACTGCCA GTTCAGGCCCCGTCTTTTTACTGGGAAATTGAAATCGTTTCCTATGGAGACACCGATGATGACACCGGACCCATAGTTTCCTTTGGCTTC ACTACAGAAGCAGAGAAGCGAGATGGGGCTTGGACTAATCCAGTGGGCACTTGTCTTTTCCATAACAACGGCCGAGCCGTGCACTATAAT GGCTCCAGTTTGTTACAGTGGAAGAGCGTTCGCTTAGACGTGACTCTCTCCCCCGGTGACGTGGCAGGAATTGGCTGGGAGAGAACTGAG GGGACTCCACCTCCTCCGGGACAGCCAGCCAAGGGCCGGGTGTACTTCACATACTGCGGGCAGCGCCTCTCACCATATCTTGAAGACGTC TCTGGTGGCATGTGGCCAGTGGTTCACATTCAGAAAAAGAACACCAAAACCCGAGCTAACTTTGGCTCCCGGCCGTTTGCCTACGCGGAA GGGCAGGCCCACCGCAATGCTGCTGACCTGTGCACTGACCTAGCAGAAGAGATCAGCGCTAACTTTGAGGCCCTGCCTTTCGCCATGGCA TCTGACAGTGACAATGATGCTGGCACCAGTATTGCATCAGACCCAGGCACTCATGGGCCACCATGCCGGATTGCTGCCGTGGCCACCGCT CAGCAACAATATGATAGTGACACCTCCTGTCATTATAAAGTCGAGCTCAGCTATGAGAATTTCATCACCTCTGGCCCAGACCCTCACCCG CCTCCCATTGCAGATGATGAAAGCGATGATGATGACGATGATGACATCCCTCAGGAGGACCACTACGCCCTGCTGGTGAAAGCATGGGAG ACCAAGGTTTTTCCTACCATCCGAAGACGCTTCCGCAATGAAGCAGAGCGGAAATCGGGCCTGGACCAGATAAAGGGGGCCTTACAACTA GGTATGGTGGATATTGCCCGACAGACGGTTGAATTTCTCTACGAAGAGAATGGTGGCATCCCAAGAGACCTTTATCTTCCCACCATTGAA GACATTAAAGACGAAGCAAACAAGTTCACAATTGATAAAGTTCGAAAAGGTCTCACAGTAGTAACCCGCTCTCCAGACAGCAATAATGTA GCCAGCAGTGCTGTTGGAACTGCTCTGCCAAAATTTGCCATCCGAGGGATGCTGAAAACCTTTGGGCTTCATGGAGTCGTCTTAGATGTT GATTCAGTGAATGAACTGGTGCAGGTAGAAACGTACCTCCGCAGTGAAGGTGTGCTGGTGCGATACTGGTATCCTATTGACATGTTGGAA AGGCCCCCAGCAGGCTACCGAAGGACTGCCACCAATGGGCTGGTCACACTGGACAATACCAACCTTCAAATTCACAGGGAGCTGCTGCGC TGCGAGGCTGCGCTGGCCAGGCTGTACTGCCGCATGGCCCTGCTCAATATCTTCGCCCCGAAGTTGCCTCACTTGTTCACTCGCCTCTTC CACATCCCTGCCATCCGGGACATTACCCTGGAGCACCTGCAACTGCTGTCCAATCAGCTCCTCGCACCTCCTCTCCCAGACGGCACCATC AGCTCCAGCTCGATCCTCCTGGCGCAGTCTTTACAGCATTGCATCCATTCCCAGAACTGCTCCGCCACGGACCTCTTTTACCAGGGCAAC TCCCAGACAGTGAGAGAGTGGCTCAACGTGGCCATCACCCGGACCCTGCACCAGGGCGAGGAGAGCCTTTTAGAGCTGACGAAACAGATC TGCTCTTTCCTGCAGACAGCACCAGAGCAGTTCCCCTCCGAAGAGTTCCCAATTTCCGAATCCAAAGTCAACATGGACGTGAATTTCCCC GGGGCAGCTTTTGTTGTTGTGTCTTGTAAAGAAAGTCAATCTGGATTCCGCAAAGACTCCTCTCTGTACAAGGCACCGTGGGCACGGGTG CTCGTATATGGCCTCGGCCACAAAGTGAAGCGAAATGGCCAGCTGAACCTCATCGAGGCCGCCTGTTACCCGCGGGACGCGTCCCCAGCC AACACTGGGCTTGCACCTCCCCCCACCGCTGACCAGTACCCCTCTGTGGTCCTCTCCACAGACAGGGTCCACATCAAACTGGGGGTGTCT CCACCTCCTGGAGCAGTCCTGGTGTTACATTCCCTGCCCCTGGAGTTCCCACTGGCTATGGCCTTCGCAGAGCAGCTGCTGTCCTGGAAA TCAGAGGACAGTGAAGGGAAGTCCGAAGATGAGCCTGACACCATTCCGACATCCGTCCTCCTGCAGGTGGTGGAGCTGCTAGGAAACTTC TTGTGGACCACGGACATGGCAGCCTGCGTGAAGGAGCTTGTTTTCCATCTCCTGGCAGAGCTCCTGCGCACGGTGCACACCCTGGAGCAG AGGCGGCACCCCGCTGGCCTGTCCTCCTCAATCGCCCTCCAGCTGAACCCCTGCCTGGCCATGCTGATGGCCTTGCAGTCGGAGCTCCAC AAGCTGTACGACGAGGAGACGCAGAACTGGGTCTCAGGCGGCGCCTGCGGGGGCTCCGGGGGGGCGGCGGCCGGTGACCAGGGCAGGTTC TCTACGTATTTTCATGCACTCATGGAAGGGTGCCTGGCTGTGGCCGAAGTGACCCTGCCTACTAACATGAGTGTCACAGCCAGTGGGGTG ACCTCAGCGACCGCCCCAAATCTCAGTGACTCGTCCTCCTCCTCCTCGTCCTCCCCAGGACAGACCCCACAGAGTCCCAGCCTCCTCTCC AAGAGGAAAAAAGTCAAGATGAAGCGGGAAAAGGCCTCCTCGTCGGGCAAGCGCCAGTCTTCCCGCACCGTGGACTCGGACCCCACCGTG CTCAGCATCGGAGGCAGCAAGCCCGAGGACATGCTGTGGTTCCACCGCGCACTCACCCTGCTCATCATCCTCCGCCACCTCACCAGGAAG GACCCACAGGGGCTGGGCGTGACGAGTGACGCCATCGCCGATGCCTGCCAGGCCCTGGTGGGCCCCACCGCCCACAGCCGCTTGCTGGTG ATCTCCGGGATCCCCACCCACCTGGACGAGGGCGTAGTCAGAGGCGCCATCCGCAAGGCCTGCAACGCCCACGGCGGGGTCTTCAAAGAC GAGATCTACATCCCGCTGCAGGAAGAAGACACCAAGAAGCCAAAAGACAAGGCCGAGGGCGGGGACGGGAAAGTTGAGCCCGAGAAGACA CTGGCCTTCCCCGGCACAGACAGCATGGAGGTCAGCACGTCCAGCAGCCTGACCCCCGCCATGAGCATCAGCGCCTCCGCCTCCACCAGC CAGGCCTCCATCTGCAGCTCGCAGGGCATCTCCCAAACCGTCAGCGACCTCTCTGTGGATCCGCTGCCTGCCGGCCTCGAGCTGCCCATC CCTCCGGGCCTGTTGGAGCCCCACGCGGTGTCCAGCCAGGAAAGCCTGGACATTTCCCTGTGCAGCACCGGCAGCCTGGGCAGCCTGGGC AGCCTGGGGGAGCCCCTGGACAATGCAGAGACGGCCTCGGTGTCGGACATGGGCTCCATGTACACAGTCACTTCCCTGGACAACCAGCCC CTCGCCGCCCGCCCCATCAAAGGCTTCGCAGTCGTGGAGATAAGATCCCGAGCCAAAATTGAGAAAATTCGAGCAAGTTTATTTAACAAT AATGACTTGATTGGTTTGTCAAGTTTGGATGGTGAAGATGAATTGATGGAAATGTCAACAGAAGAGATTCTAACCGTGTCTGTAGTAAAT CAGAGTCTCTTTGATACTCAAGGGAGCCCAGGGTTAGAAGATTATTTCAATGATAAGTCAATTAAAGGGGAGAAGCTGGTGCCCGGAGCC AGAGAGGTTCTGACGGAGATATTTAAGAGTTGTGCCCATTCAGAGCAGACGCTGAGCCTGACACCAGCGAAGCCCATCAGAGTCTCTGAC ATTTATCTTAGCAAAGAGCAGATCAACTCCCAGACCCCAGGCAACCTCCTCCACCTCTTCTTCACCAATGTCCGGCCGCCAAAAAAGGTG CTGGAGGATCAGCTCACCCAGATCCTGAGGAAGTATGGCGTGCCAAAGCCCAAGTTTGACAAGAGCAAGTACAGCAAGGCCGGGAAGGAG CAGCACCCCGTGAAGGTGGTGAGCACCAAGCGGCCTATCACCAAGCCGCCCGCCAAGGACAAGGCTGTGCTCAACAGCGTCAGCAGGACT GCCTTAAGTGAGAAGAAGCCAACTGTGAAGCCAAAATCACCAGAAAAGAGCAAACCAGATGAAAAGGACCCAGAAAAGTCACCTACCAAA AAACAAGAAGTCCCTGAGGAAAAATACCTGACGCTGGAAGGATTTCACAAATTTGTTATTGACCGAGCCAGGCAAGATATCCGTAGCGTC TGGAGGGCGATCTTGTCCTGTGGTTACGATCTTCACTTTGAGAGGTGCGCATGCATCGATGTCCGACATGCACAGAAGGCCTCAAGAAAG TGGACCCTGGAGATGGACGTGGCACTTGTGCAGTACATCAACCAGCTATGCCGCCACCTCGCCATCACACCCGCACGGCTCCATCCCCAT GAGGTGTACCTGGACCCCGCGGATGCTGCTGACCCCAGAGTGGCCTGTCTCCTGAACGTGCCCATCGAGAGCCTGCGCCTGCGCTTCGCC TTGCTGCAGTCCCTCAACACCACACTGGAGACCTTCTTCCTGCCCCTGGTGGAGCTGCGCCAGACACCCATGTATACCCACAGCATCGCC GCCCTGCTGAAGGAGGCCAAAGGGCTGATCTTCTATGACACGAAGGTGACCGTGATGAATCGAGTGCTGAATGCCACTGTGCAGAGGACA GCGGACCACGCGGCCCCTGAGATCACCTTGGACCCACTGGAAATTGTGGGAGGGGAAATCAGAGCTTCTGAAAACTCCTACTTCTGTCAG GCTGCCAGGCAGCTGGCCTCAGTGCCGTCGTCTCAGCTCTGCGTCAAGCTGGCCAGTGGCGGTGACCCCACATATGCCTTCAACATCCGC TTCACTGGCGAGGAGGTCCATGGCACCAGCGGCTCTTTCCGCCACTTCCTGTGGCAGGTGTGTAAGGAGCTGCAGAGTTCCTCGCTGTCG CTGCTGCTGCTGTGCCCCAGCTCAGCTGTCAATAAGAACAAGGGCAAGTATATCCTGACCCCGAGCCCCATCACCTACGGGGAGGAGCAG CTGCTGCACTTCCTGGGGCAGCTGCTGGGGATTGCAATTCGGGCAGACGTCCCGCTGCCCCTGGACCTCCTGCCCTCCTTCTGGAAGACG CTGGTGGGCGAGCCCTTGGACCCTGAGCAAGACCTGCAGGAAGCGGATATCCTCACCTACAATTACGTCAAGAAGTTTGAGAGCGTCCTC ATCCTATAGCCCATCGCCTGTCAAGAAAAAGAAGAAGAAAAGTTCCAAGAAACACAAGCGACGCAGGTCATTCTCCAAGAAGAGAAGGCA CAGCTCCTCTAGCCCAAAAAGCAAAAGAAGAGATGAGAAGAGGCACAAGAAACAATCTCGAAGCCGGCCCCGAAAGTCTCACCGCCACCG CCATCACCGCTGCCCCTCGCGGTCCCAGAGCTCGGAGTCCCGCCCCTCAAGCTGTGAGAGCAGGCACCGCGGCCGGTCCCCTGAGGAAGG GCAGAAGTCCCGCCGAAGGCACTCCCGCCGCTGCTCCAAGACCCTCTGCAAGGACAGCCCTGAGGCCCAGTCCAGTCGCCCGCCCAGTCA ACCCCTCCAGATGCTTGGCTACCTGTCAGCCAGGGGTGTAATCACTGGGTCGGGGTCTGCTGCTGACCTCTTTACCAAAACAGCCAGCCC GCTCACCACCTCGCGAGGACGTTCCCAGGAGTACGACTCAGGAAATGACACGTCCTCGCCACCCTCCACGCAAACCAGCTCAGCCAGGTC TCGGGGCCAGGAGAAGGGGAGCCCCAGTGGGGGCTTGAGCAAGAGCCGGGAGCTCAACAGTGGCAACACCTCTGATTCAGGGAACTCCTT CACCACCTCCTCACCCCAGAACAAGGGGGCCATGTTGGAGAATCTCTCCCCCACCAGCAGGGGCAGAGAGTCAAGGGGATTTCAGTCACC GTGTCTGGAATGTGCCGAAGTGAAGAAGTCCAGTTTGGTCCCATCCACAGCCCGGAGCTCACCCATGAAAGGGTGTTCCCGCAGCTCCTC CTATGCCAGCACCCGATCCTCCAGTCACTCGTCCCGATCCCCAAATCCCAGGGCTTCCCCCAGGTACACCCAAAGCCGATCCACCTCTTC TGAAAAAAGGTCCTACTCCCGCTCTCCCAGCTATTCCTCCAAGTCTGGCAAGAGGAGCCCGCCCAGCAGAAGCTCTAGGTCCCGCCGCAG CCCTAGCTACTCCCGCTACAGCCCCAGCAGGGAGCGGGATCCCAAATACAGTGAGAAGGACTCGCAGCAGCGGGAGCGCGAGCGAGCGCG TCGGAGACGTCGGTCCTACTCGCCTATGAGAAAGCGCCGGAGAGACTCCCCGAGCCACCTGGAGGCCCGGAGGATAACCAGTGCCCGGAA ACGCCCCATCCCCTACTATCGGCCCAGCCCCTCCTCATCCGGCAGCCTCAGCAGCACCTCCTCCTGGTACAGCAGCAGCAGTAGCCGCTC GGCCAGCCGCAGCTACTCCCGGAGCCGGAGTCGGAGCCGGAGCCGGAGACGGAGCCGGACCCGCACGAGCAGCAGCTCTAGCTCCCGCAG CCCTAGTCCGGGCTCCCGCAGCCGGAGCCGGAGCAGGAGCCGGAGCCGGAGCCGGAGCAGGAGCCAGAGCCGGAGCTACAGCTCAGCAGA CAGCTACTCCAGCACGAGGCGCTAAGTGCCCCTGAGCCAGCTGCCCGTGGGGGCCCCTTCGCGCTGCCAGCCTCCCCCAACCACCTGCCC TCCCCGCCTTCTTGGTGACAAATAGTGAGGGCTCCTATACCTTGTCCTTCCTGCTTGCCTAGGGGAAGAGGAGAAGAGGGTAAGGGGGCT TCACTCTCTAGATCAGCCTGCTAGGAGCCTCTACCAGCATCATCCTGGGGCCCAGCTCAGGCCTGGGCATATGGAAAGAACCATCATCTT GTGGCACAAAAAAAGAAGAAAGAAAAGAAAACTTCAAGGTTTTGTGAGAAGCAATGGGTCTGTGACTCAAAAATTGAGCCCTGGCCAGGA AAATGTGGAGACAGTTCTTCTCCTCCACTGCTCACAGGAGGCCCGTGGTAATTCTCCCCACCTCCCCGGATGCCCCACTAGTCCAACTTC ATGGCTGCACGTGGATGGACCCCCATGTCTGAGAGGGGTGAAAGAGGAGACCAATGGCAGTTCAGGTTCAAGATAACGGGGTCAGGCCTT TAACTTCCTCAAACAGGCCCAAGCAAAGGCTGGAAGACATTTGGGTCCTAGAAGAAGGGATATCCTTGAATACCAGATGGGGACGTTTGA CTTGGTGGGAGGTGTCAGGAGATAGGAGTTGGTTAAGATGATAGATAGAAAAACGGAAGGGTTCAGCTGCTGCTCCCAATACCTCAGCAT GGTAAGGGGACAGAGCCCAGCAGATCCCAGCTGTGAAGAGGCCACTGCATGGCTGACACAAAACACCTCTTGGCCATTCACAGGGGCCCT GCAACCTCACGAGAAAGGAGATAGTGGAAGAGTCAGGACAGGTTGGTCTCCAGCCCCACTTCCCAAATATGCCTCAGCCCCACTAGCTGG CACCAACTTAATTCCACGGGACCATCTGCTGAACATTCCCCAGTGCCATGGCCAGTTGCCAGGCCCCAGCGCCAGCCAGTCTGGCCTTAC CCTCCGGTTGGCGCCTGCCAGCCCCCTCCCCTCTGCCCAGGCTGCCACGCCCTGGATGCCACCCAGTGCAGCCTGGCACCTACCCACCCA CCCTTCAGCTTAAGCCACTCCCCTTGCCTCTCAGGAATTTTGCCAGGATGGGGCACAGCAGCTCAGGTTTGGGGGAAAAGACCCGAATCC AGAGTGCAGGGGAGAGGGGCTTGGATATGCCATGTCTTGGGCTCCTGCTGGCTTCTGAGGTTTCTTGTCAGCTTGGGAAAGACCCACCTT TATTTTTGCCCTCACCCCAAGTCCCCCCTGGCTGGGGCTGGGCAGAGAGGGTAAGCTGATCTCCGATCCACAAATACCACCAGCTGCTTC ATCCACAGAAGGCGCTAAGAACGGGGAGGTGAGGAATAAGATCCTTAAAATAAACTCTTGGGCATCCCCCTCACCAGCTGACTGGCTTTC CGGAGGCTTGTGGGTGAGTTTCAAGTTTGTGGTGGCAACAGCAGCAGGACAGGGCACGGAGGGAGCGAGGGAGAGAGGACCGGTCCCAGC TTTTGGATATTTTGGGTTATGGGGAAGCAAGGGCCAAACATTCTTTATCCCTCCCACCCCAGGGAAAACATTTGGAAAATAGTCCTTTTT CTTGGAAGCAGTGACGTCTCCCTACCCAATCTTTCCCATCCTATCAACCCATGGGGCTAGAGACTGCCATGCAACCACCACCACGACAGC CCTTCCTCCATCAGAAGACAGGAGTGAGGGCCCCGGGCAGCAGTGGACGACCCAGCCTCCCCATACCGGGCCTCTGGCCCAGACCTAAGC CCTGCCCACAAAGACTAATGGATGCCAGTGCTGTCACTGCAGAAGGCCAGATGGCAGGTGCCTGGGACAGGGGCAGGTGCCCCGGGGAGG GCAAGTACAGCCACTGTAAATAACCCTCGTCCCTGCCCAGGAACCCAGACTGGACTTCAGTCTCCCTCCATGGAGACAAAGGCTTCCCAG AGCCACCAAAAACCTTCTTAGCAGGACAGCTGTGAGAGGCATCAGAACCTCACGTTCGGACTGCCTTCATCAAGACAACTCTAGGGGACC ATTTTGCCTGGGGCTCCTAGCAAACCTTTTTATTTATTTTATTTATTTATCTATTTATTTATTTGATGACTGTCTCTCTTTCTCGCCATT AGCAGTATTGAATTATTTATTTATACAGAGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGGG GGATCTCCTAAATTATTTCTGTGCATCTCCTTTTTTTTTCTGCTGTTTTTTATGGATGGGATTTGAGAGGCCAAAGGTGAGTGGGCTATT GGCCTTCTCCCTGAAGGCTCTAAGCCTGGAACACCCTGGGGTTGGCCCAGAAGGAGGCACATCAGTCCCAAAATTCATCACTTAACCCAG CGTCCAGGAGGGTCAGGCCTGTACCCCAGCCTCCTGTCCCCCAGGAACCTCACAGGGGTATCAAAAAGATGTAAACAGCCCAGAGGCTTA TGAGCTACAGTGATGAATTGACACAGTGGAGTTGCAACTTAGGTGGGGGTTGGAGTCGAAAGTTGGCAAATGGGGCCAAGGCTGCACAAA GTCGAAATCCCTTGTGAATGTCCCTTAGGGAGGCACCAGATTGGAGACAGATGTGCTATCTCCTAACAGAGTGATGAGGCTTCAGTTGAG TACTTGCTGAAGTAGTTGCCTTGTATTTTGAGGGCCATGGTGGATGAAAATGATGTCTGGTTTAGTACTGGAATTGCACTTGGGGTTGAC AAGGTGCTCACACCATGAGAATGGAGGCAGGAATTGAGCTGACTGAGGGAAGATGCACCTTGATCTCACCCTCACTCCAAGGCACATAGC AGGATCACTCCCTAGCTTCTCTGAGCACACCTAGTTGGTTTCATGTATGTTACACATGCTTCCACTCCACAGTACCTAATTTCTCTCTGT CCCCTGAGATCTGAAGGCTACCTTGGGAAGAGGCATCAGCCATCTTGCTTGAGAACCACCAAGCCAAAAGCAAAAGCTTTTATCTATGAT CTCTTGCTGTTTCATCAGGGGAAAGCACAAAGCTATTTCTGAAATTAGGAAAAAAAAAAAAAAGGTGGAAGGAGCAGCCAGATGTTCCAC AGGACCCCACCAAGAAGGTCATTTCCAAACCCATCCTGGAAGGGCCCAGGATCCAAAGGTCATCAGTCCTGCTTATCTGACCAACTGGCA GTGTCTTCTGGCTGCTGGCCGGAGACAGCTCTTGCCCTTTCCAAAGTCACTGTCCACTGCCTTGCAATTGCCAGCTTGTCTGGTCCAGCT TTGGGTTTGGTGAGACTTTTGCAACATCCCTGGTTGTTTCCCTGGCAATGTGACTATCCAGCCCTAACCCAAAGCAAGGGAGTGCCCCTT TCCTGGGTGAAGTTTACAAGAAGGCTGCTTAAATGCCTGCTTCGGGGAAATCTCTGCCTCTCTCTCTCTCTGTCTCTCTCTCTGTCTCTC TCTCTGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTGTATTTCTCTACTTTCTTTTACATTTCCTTTTTTTCTATCCAAAAAC AATGTGCTTGTTGAGGCACTGGTAACCCTGATTAACCAGAACCTCCCATTCCCAGTATCGCTGTTCCTACGCCCATTTCACCCTCATTAC CTTCTGCTTCCAAGGAATATGACAGATCACCAGGATGCTGCTCGTCGTGAGGATTTATCTCAAAAACCAACATCCAAAATGGGAGGGAGA TGTGGCTTGAGGTCAAGCGCCATGCATCCCAAGCCTTTGACCTTCCCGCTATGGAAGTGCACTGGATGACAGAAACTGAATACATTGCTC CCTTTCCCTAGGGCAAAGTTCGACCTCTGTTAAGTGGAGGGATTTGTGAGATAAAAATTCAAAATGTTGGCCTGAGGCCTGAGAGTGTCA CCAAAGACAGAGGGAGCTTCACTGAGACTCAGAGGGAAAAGGAAAAGAGCCTCAAACATTTTTAGGAGGTTGTCCATCATGAAAGTAAAA ACGAAAAGCAAGATTTGATCTCCCTTCAGTTAATTAGGCAAGGCTAAGTAACTCAAAGCCCCCTATTAGTAACATTCTGGTTCACTGAGG TTTGATCATATTCCTATCTGCATTCCTTCCCTTCTTTGAAGGACAGCTGATCTTTCAGAAGCAGAATAAAATTAAGATGTTAGAACAAAG GTCTCAGTCTCAGAGAACCGCATCACTTCATTTGCTCAGACCCATCCTCTTTTGCAAAAGGGTCTGCTTGGAGAGGCCAAAATTCAGGGT GCTCTCAAAGGCAAAGAAAGCACATTGTTTTCCTTCTCCAGTCCAACTTTCATCTTTTCTTCTGCTGTTTTCTTTTCCCCTCTTCTTTTT CACAAATGTTCAAAATGGTCTCATGCGCATGTGTCTTGCCCCACTTTCCCCTTTAGCTGAACAGAAAATTTTGTCTCAGTAAAACGAAGT CAAAAAACAGGATTCCTCCAAACATGCCTCCTCCCGCACTGGCCAGCCGAGTCCAGCTGAGAAACTTATGCTAGATTCAATGTCATTGAG CAATGCTTTATTGAAGTCTCGTTCTTCTCACTTCTGCACCAGTGAGCCAATGATACTGACAGAAATGTCATCTCTCTTCTATCTGTGGTT GCTGTTTTTGGAGTAAAAGTTTCTGTGTGTGTTTTTTTAGTTCTTTTGATGGCTGTTGTTTTGCATTGTAAATACCATGATGGGGGACCC CCATCAGAACATGGCTTATTTAATAATTTATTTCGTATTTATTGAGTAATATTGGGAAAAGAGAAGGACCACCTCTTTCCCTGAATTGCT ATTGAGAATTGGTCCATCTCCCAGCTCCAGGTGCTGCTGTCTGCAGCAAGGGCATTACTGCCCAGGTAAGGAGTGCTAGAATCACCAAGC AAATTGAAATTGGCAGAAATGGAGGCTTCAGTCACACAAATTAGACTCAAATGGAACTAAAACACTGGTTATCTCCAGGAAAACCTCATT TAGATGGAAATTAATGGAAGAATAAAATGCCTACACATGAACCAACTTCTATTAAAAAGTCACAACTCCTTGAAAAAAAAAATAAAGAAA AATTGTAAACTCTTTTTTTTTTCTGGCCAAGGAAAGCTATGCCTCATCTTCTAACGAGCCAAGCCAAAAAGACTGCAATGGTATTCCTAT GTGTTTCTTTGGCCTGTGTATCAGTCTGAATGAAATGGAATGGGTCTCTAGCCTCAGTCTTGTCATCTGTAAAATGGGGCTTGTCCTATA TATTATCTGCAAGACGTGGGAAATGGGGGCTCAAGCCCTGATGCTATGGACTCCATACTGTTGGATATATTGTCTCTTGTGTCTTCTGCT GACTGCAGATTAAAGGGTGTCAACCAAGGAAGGAAACAAAAAAGTAGGGCCTGGACTTCATTTGCAGAATGAGGTCATAGTCGTTGAGTC CCACAGTCATATATGGGAGACCTCAAGTTGCTGTCACCTTGATAACTCTTGTATCCTGGGTTAAAGCCCTCTGTATTTAGTTTGAACTTC TCTCTAAGCCCCGTGGTCCAAAGTCATCACGGGAGAGACCAAGATGGGCTTACCTTGCCCTGCTCTGGATTTAACCATTGTTCATTGTCA GGCTATATTTTTGTACAATCATTCAAATAACCCAGTGACATAGGTCATATTGCCACTTTTCAGAGGAGAAAACTGAGGCTCAGGAGGGGG AGTTGACATGCCCAAGCTCCCTTGAGCTCAGATCAGCTTGACTCAATGTCCAACATTCCCTTGGTAGCTTTTTCTCCGGGGTCCTGTGCT ATAAGAACTTCTCTCTGCACTGTATTTTTTTTTCTCCCAATTCTTAGCTATTTCCTCAAGCAATGATTGGCCAAGGACCTAGCATAATCC ACCACATTGGCCAAGGGGACGTGGTGCACCCCAAGGCCATTTCTCTGCATTGGAGGCTGCGAATCTCCTCTGGAAAATTCCCAACCCGAG GACCCACCATGAGCCCAGCTCAGCCTGACCAGACAGCCTCTGCCTGGAGCATTCACATCAGATGGAAAGAAGCTGCTGTGTCCTCCAGCA TCCTGGGACCCTGTCCTCTGCCCAGTGACACAGCAGCCATGGCTAGCTTGATTTCTGGTCTCCAAAGCTAAGCATAACCTTCCCGGGGTT >36048_36048_1_HECTD4-SRRM4_HECTD4_chr12_112605121_ENST00000377560_SRRM4_chr12_119554742_ENST00000267260_length(amino acids)=4125AA_BP= MHDGLIRVTDLAELPSEILGAPEAADTDLEILTFETKNPSELAERLRSVCGNQSNAYARLLEYRLNALRGLWNAQRQLALEEQHERESSG DEETLALLKRQGLLQQPEQAPFTSRMGLLLVFPLIQSQSRTDPSLCNITAEVLLNCLRDCQPLSLTKEPADCLNGIETLLCSWLEETSDT GRHIPHKQKENAAAALVALACARGSLKTFVHTVHLLQKQTDLGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIVSWGYEDMLPAPDSNTG SSSENKDADLGRCLTADGLYLYTTNSVGRGVSKLGSGLHGTLRGFVYCRNEELEPGWVAFGSGSLLHRPVSFDNKPHSLFQVIDQNTLQV CQVVPMPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKSINEMLLS RLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKRACYDTV NNMLWTCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQLLHHVGAMCIHQLNLLATNPNLPITSVLGKQHPIEAHH LSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFFSPQTERNRDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEI NNLLKLVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCILITKCQTVSKDDFQKLLSTVPAASS CLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGETLKVQELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTK ATMLGHLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAPDQKCRLFPDERMLEEKEEPGFLTGL KIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARCLYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDL VKCISPPSLNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALGLSVLACSMLRILYNGPEITKEEEA CQELLRSKLLQRCQWQVEANGVISPALTPSPSPLPLTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIK EVIQPDVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQSVAELEQKWQSEVDDAMQGKLENNMP FFYDYHFNENKMKELELLCSMKEVSFDGNDLENMVLSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLTRSIS GTPAETPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSSFTLLQSLAIEDSRDKPTYSVLLGQLF AFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTSV VSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKVATMAWAAFQVLANRCVEWEKEEGGST EAVHSGLARQVSSLLTNHLARATECCGNQAAGNDALQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRAAL PLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPDTTLTKTSPKNSLKGDKDPGEESEAV DGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGGCCEVITEEAAAALRKATKWAQSGLIVSIGPPVESIN PETVSGLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKY AESILENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINEQEGIATVRFPPIDCRKTSQASDTLTI PLSRLCVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEIRTRACLVMAQLLEDSLFCEEFIQQC PAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGL PRGTFIYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSLLQWKSVRLDVTLS PGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEE ISANFEALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFITSGPDPHPPPIADDESDDDDDDDIP QEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLDQIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKG LTVVTRSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRYWYPIDMLERPPAGYRRTATNGLVTL DNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHS QNCSATDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISESKVNMDVNFPGAAFVVVSCKESQSGFR KDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAACYPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFP LAMAFAEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHLLAELLRTVHTLEQRRHPAGLSSSIALQLNP CLAMLMALQSELHKLYDEETQNWVSGGACGGSGGAAAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPNLSDSSSSSSS SPGQTPQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTLLIILRHLTRKDPQGLGVTSDAIADACQ ALVGPTAHSRLLVISGIPTHLDEGVVRGAIRKACNAHGGVFKDEIYIPLQEEDTKKPKDKAEGGDGKVEPEKTLAFPGTDSMEVSTSSSL TPAMSISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCSTGSLGSLGSLGEPLDNAETASVSDM GSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFN DKSIKGEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFTNVRPPKKVLEDQLTQILRKYGVPKP KFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKAVLNSVSRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHK FVIDRARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLAITPARLHPHEVYLDPADAADPRVACL LNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVG GEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGKY -------------------------------------------------------------- >36048_36048_2_HECTD4-SRRM4_HECTD4_chr12_112605121_ENST00000550722_SRRM4_chr12_119554742_ENST00000267260_length(transcript)=20216nt_BP=12492nt GCGGCCGCTGACTCGGCGCAGTGGCTCTCGGTGAAGGAAGAGACCATCTTCCTGCACGACGGGCTGATCCGGGTCACCGACCTGGCCGAG CTGCCCAGCGAGATCCTCGGGGCCCCAGAGGCCGCGGACACCGACCTGGAGATTTTAACCTTTGAGACCAAGAACCCGTCGGAATTAGCA GAACGTTTGCGCTCTGTTTGTGGGAATCAGAGCAATGCCTATGCCCGGCTGCTGGAATACCGCCTGAATGCCTTGCGAGGACTGTGGAAT GCCCAGCGCCAGCTGGCCTTAGAAGAACAGCATGAAAGGGAAAGTTCAGGTGATGAGGAAACTTTGGCCCTGCTCAAACGCCAGGGCTTG TTGCAGCAACCTGAGCAAGCGCCCTTCACATCGAGGATGGGGCTCCTGCTGGTCTTCCCCCTTATTCAGTCCCAGAGTAGAACAGACCCC TCTCTCTGTAACATAACTGCTGAGGTGCTATTGAACTGCCTTCGTGACTGCCAGCCTTTGAGCTTGACCAAGGAGCCTGCTGACTGTCTC AATGGAATTGAAACTTTGCTGTGCTCTTGGCTAGAGGAGACTTCTGACACAGGCCGACACATCCCACATAAGCAAAAAGAAAATGCTGCT GCTGCCCTGGTGGCTTTGGCTTGTGCCAGGGGATCATTGAAAACTTTCGTCCACACAGTCCATCTATTACAGAAACAGACGGATCTAGGG TCCCTGCCTGTAGCTGATGTGCTATATAGGCTGTTGCTTTTGGAAGGGGGGCCTGGATCTCCCTCCTGTTTGCTTGGGGGCAAACACATA GTATCATGGGGTTATGAAGACATGTTGCCTGCGCCGGATAGCAACACTGGCTCCAGTTCTGAAAATAAAGATGCTGACTTGGGACGCTGT CTCACGGCAGATGGTCTTTACCTGTATACTACTAACTCAGTTGGAAGAGGAGTAAGCAAATTGGGATCTGGATTACATGGTACTCTCAGA GGTTTTGTGTACTGCCGGAACGAGGAGTTGGAACCAGGATGGGTGGCTTTTGGCAGCGGCAGTCTTCTCCACCGGCCTGTCTCTTTCGAT AATAAACCTCACTCCCTTTTCCAGGTCATTGACCAGAACACCCTTCAGGTGTGCCAGGTGGTGCCAATGCCAGCCAATCACCTCCCCATT GGCAGCACCATGAGCACTGTGCACCTGTCTTCAGATGGCACTTACTTCTATTGGATCTGGTCTCCTGCCAGCCTGAATGAGAAAACACCG AAGGGACATTCTGTCTTCATGGACATTTTTGAACTTGTGGTTGAAAATGGTGTATTTGTAGCCAACCCACTTCAGGAACGTACAATTCTA ATGAGAAAAGAGGGCGAATCTGCCAAAAGCATTAATGAGATGCTTCTAAGTAGACTTTCTCGGTATAGAGCCTCCCCGTCAGCAACGCTT GCTGCCCTGACTGGTTCCACCATCTCCAACACACTGAAAGAGGATCAAGCAGCAAATACTAGCTGTGGGCTGCCTCTAAAAATGCTGCGG AAGACACCCATATATACCTGTGGCACCTACTTGGTGATGCTGGTGCCTCCTCCAGGGGGATCAGGCAGCTCTGCCACCCGATCTCTTTTT GGTGGAACAAGTGGTTTGTCATCTTTAAAAATCCTAGCCTCCAGCTTGGTGTATAATATTTCGGATGGTCAGTTTACAAGTCGTGCAGAT CTCATAGATGCTGCTGGAAGCTCACTGGGGCGTGGTGCTCTCGTACCAGGATTGGGAGCGTGTTATGACACAGTGAACAACATGCTATGG ACATGCTCAAATGACTATATCGATCAGTGGTGTAACCCTGGGAATCAAGCCTTCCATTATGTCTGCCAGAGACTTGGAGTCAGTCACATT ATCACTGAGCCCAAAGAAGAGGCTATAACCACGAATGAGGTTATAAACCAATTATTGCACCACGTTGGTGCGATGTGCATACACCAACTC AATCTTCTTGCCACCAACCCCAATCTTCCAATCACAAGTGTCTTGGGCAAGCAGCATCCAATTGAAGCACATCATCTTAGCAGTATTTGT GACATTATGGAGAAGGCCATGGTTAATGGAGATACCTGTATTATACGCTGCATTCTCGTTGTCTTTCAGGTGGTATTTAAATTTTTCTTC AGCCCACAAACTGAAAGGAATCGAGACATCATTCGACGGTCGGGATTGCTTCTTTGGCAGTTGTTGATGGCTCCAAAAGATCAAATTTGC CCTGAAATTCAGAAGGAAGTCTGCCTTGCCATCAGCTCTGGTTTAAATATCTTGTACCCAGGTGAAACTGAAATCAATAACTTACTTAAA CTGGTCTTAACAGAAGGAGAGAGAAACAGTGGACTCTCCCAGCTACGGGATGTGATCCTAACCAACCTGGCTGAACAGCTCCAAAACAAC CGATTTGGCAGTGATGAGGATGATCATTACAGACTAAATGATGAACTTTTACACTACATTCTGAAGATTGTTGTACGAGAATCCTGTATC TTAATCACCAAGTGCCAAACTGTCTCTAAAGATGATTTTCAAAAGCTCCTTTCAACTGTGCCTGCTGCATCCTCCTGCCTGCGCTATCTG ATGGCAGTTCAGAATCACCTTCTCAGTAACACTATTTTGATTAAACCTGATGAGAATGATGACAGTGACAGCTCCTTGCAGGGAGAGACA TTGAAGGAGCTAAAAGTCAGTATTTTGGCTCTTGCCACCCAAATCCTGACTGGATGTGATGAAGTGTTGGAAATGCTACAGCAGGTCACA ACTGCCCTCATAAATAGTGACATAGCAGACCGTGAGCAGAGGTTAAAAGGCTTGGAACAAGTTACTAAGGCTACTATGCTTGGTCACCTT CTTCCAGTGTTACTGACCTCCTTGATGCATCCAAATTTACAGACTCTGATCATGGCGGATGCCCTGATGCCTCAGCTAGTGCAGCTGGTA CTCTATACCAGCCAGACGGCGTTGCTGCTTAAAACCCAGTGTCCGGTTTTTGCTGAGGTGGGCTGTTCCCCGTGTGGTGCACCAGACCAG AAGTGCAGGCTGTTCCCTGATGAGAGAATGTTAGAAGAGAAGGAAGAGCCAGGATTTCTCACTGGTTTAAAGATTCCTGCCCCATGGGCT GCTGGAAAGACTGTGGAAACAGTCCACCCCGTCAGAGACAACTATAAATTTAAAGAAACGGTCCATATCCCAGGAGCTCGCTGCCTGTAC CTTAGATTTGATAGCAGATGCTCTTCGCAATATGACTATGACAAATTGGTGATATATGCGGGGCCTAACACAAACAGTAGGAAGGTTGCT GAATATGGAGGCAACACACTGGGATATGGCAGCCGTAGTGTCTTAGGAACTGGTTGGCCGAAAGACTTGGTGAAGGTGGAAGGAGATACA GTCACCTTCTCCTTTGAAATGAGAAGTGGCCGTGAACACAACACTCCTGATAAAGCCATGTGGGGCTTTGCTTGCACAGTTCGCGCTCAG GAGTCTTCGGAGGATGTCTCAGGAGGCTTGCCCTTTCTGGTAGACCTGGCTTTAGGTCTGTCTGTGTTAGCTTGTTCCATGTTAAGAATC CTGTACAATGGACCAGAAATTACCAAAGAAGAAGAAGCCTGTCAGGAGCTATTGCGGTCCAAACTTTTACAAAGGTGCCAGTGGCAGGTG GAGGCCAATGGCGTGATCTCCCCTGCCCTTACTCCGAGCCCCTCTCCACTGCCTCTGACCATAGAGGAAGACAGAGAATTCACCTACCCC TCTGATGTCCTCGTGCCTCCTGTTGGAAACTACTTTGATCTGCCTCGGATCAGACTGCCTCCAGGAATCATGATAAAGCTCAGGGAAATT TCTGGGCGTGCTAGACCTCAATTTAGACCAAGTATAAAAGAAGTGATTCAGCCAGACGTGATGGAGGAAATGGTGGTATCTTGTGTTATT AAGCACTTGAACTTGGTTGATGCACTGCAGTCTCTAATAAATTTCCAATATCAAGAAGAACATGCTGAAGAATATGATTTATTATGTAAA ATTATGGGAGAGACCTTTAAGAAACTCAATGCCATGGAGAGACAGCTGCAGAGTGTTGCAGAACTGGAACAAAAATGGCAAAGTGAAGTT GATGATGCCATGCAGGGGAAACTGGAGAACAACATGCCTTTCTTTTATGATTACCATTTTAATGAGAACAAAATGAAAGAACTAGAACTT TTATGTTCAATGAAGGAAGTCTCCTTTGATGGGAATGATCTTGAAAACATGGTCCTATCACTGAGGGAGAAGTTCCTACAAGAAGTGAAT TCTCTTATTCAGAAACCCTCACACCCACTGGCTAAAACAAAGACGTTAGTGAAGAGTTTAATGAACCGAGCCGAGCTGTTGCTGCATGTC ACCATCGCAGCCCAGTCGGGCCTCACGAGAAGCATCTCTGGGACCCCTGCTGAAACACCAGCTTGTAAATCAGCTTCTGAAACAAAAGTG ATATCTCACGCTGTCAGGCAGCCTGTTTTTCTTCGCAGCATGTCAGCTCCTTCTGACCTGGAAATGATTGGTAATGAAGATTTGGAATTT ACTAGAGCAAATCAGAGGCGTCGCCACGTGACCAGCCACCGCAGCAGCTCCTTTACACTCCTGCAGTCGCTGGCCATTGAGGACAGCAGG GACAAGCCCACCTACAGTGTCCTGCTAGGGCAGCTGTTTGCTTTCATCGGCACCAACCCTGACCAAGCTGTGTCCAGCAGCAGTTTCCTT TTGGCTGCACAGACAAGGTGGCGGCGGGGAAACACTCGCAAGCAGGCACTGGTGCACATGCGGGAATTGCTGACAGCTGCCGTACGAGTC GGGGGAGTGACGCATCTTGTGGGTCCAGTGACGATGGTCCTTCAGGGAGGACCCAGAATTGAAGAACTCACATGTGGTGGGATGGTCGAG CAGGTCCAGGAAGCCTTTGGCGAGACCATGACCTCTGTTGTGTCTCTGTGTGCTCGTTACCCTATCGCTTGCGCAAATAGCATTGGACTC TTATGTACCATACCTTACACCAGGAGCGAAGAGAAGTGCCTGGTACGCAGTGGCCTTGTGCAGCTCATGGATCGACTGTGTAGCTTGAGC AATCAGACCGAGTCCAGCTCCAGTGAGAAACAGACCAAGAAGCAGAAGGTGGCCACCATGGCCTGGGCTGCCTTCCAGGTGCTTGCCAAC CGCTGTGTTGAGTGGGAAAAAGAGGAAGGTGGCTCCACAGAGGCTGTGCACTCAGGTCTGGCCCGGCAGGTGTCCAGCCTTCTCACTAAC CATCTTGCCCGAGCCACAGAGTGCTGTGGCAACCAGGCTGCTGGGAATGACGCGCTCCAGGATGTCCTTAGTCTTCTCAATGATCTCTCA AGGAGCCACATAGGTAAAGCCATCCTGAGCCAGCCAGCTTGTGTGTCCAAACTCCTCTCCCTGCTGCTTGACCAACGCCCGTCTCCAAAG CTAGTCCTTATTATTCTCCAGCTGTGCCGGGCGGCGCTGCCCCTGATGAGCGTAGAAGACTGTGGAAACGTGGAGCTCCCACCCTGGAGC TACTCTGTCCCCTCCTTAAACAGTGAGCAGGAGGATCCCAGCGACCCAGCTTCCAAGATCGCCTCCCTGCTCTTAGCAAAGCTGGCAGAT TATGTGGTTCCAGGATGTCAGACAGTTCTTTCTCCAACCGCTTCTGAACCTGACACCACATTGACAAAAACCAGTCCCAAGAATTCCTTG AAAGGAGATAAAGATCCTGGAGAAGAGAGTGAGGCTGTGGATGGCAAGCTCTCGATATTTATCCACAAGCGGGAAGACCAGTCATCCCAT GAAGTCCTCCAGCCATTGCTAAGTAGTTCAGAAGGACGGCCCTTCCGACTTGGTACTGGCGCCAACATGGAGAAAGTTGTGAAGATGGAT CGAGACATGACCAAGGGTGGCTGTTGCGAAGTGATTACAGAAGAGGCTGCAGCCGCCCTGCGGAAAGCCACCAAGTGGGCACAGTCAGGC CTCATCGTCAGCATTGGGCCACCTGTAGAGTCTATCAACCCAGAGACTGTGAGTGGACTATCCACAGGCGACAAAAAGAAAACTGCCCAA ACTTCCATTTGCCGAGAGAGGAACTCGGAGCTTGCAAGGACTGATCCTGTGCGTCCCTTCATCAGTGGGCATGTGGCAAACAGCATGGCT GCAGAAGTGATCGCCTTGCTACATAGCTTGCTCATGGCACCTGAATCAAATGCTGCTCAAATATGGACCACAACAGCAGAGAAGGTTCTG TCTAGAGCACTGATGTACATTCCACAATTGGGGAAATACGCAGAAAGCATTCTGGAAAATGGCAGCAGCAGTGGCAGGAAACTTGCCAAA CTTCAGAGAATTGCACGCCAGGCCGTTGCCGCACTGTGTGCACTTGGAGGCTTCAAAGAGACAATCAAGATAGGATCCGAGGTTCAGGTT TTAGGTAGAGGAATTTCAGGAAGCATTGGAGTAGTGGCTTCTATCAATGAACAGGAAGGTATAGCTACAGTCAGATTCCCACCCATAGAC TGTAGAAAGACTTCGCAAGCGTCAGACACATTGACTATTCCATTGTCTAGACTTTGTGTTCCAAGATCAGAGGCATTGCCTCTTCATAAA CTGTCCATTACTGAGAAGGTAGTACAGGCAGTCCAGTCCATGTTGCTTCCTCAGGAGGGAAGTCTCTCTATTCACACCTCACTTCCTGCA ACAGGAGATGGGTCAGCTCCTGTGATGGCAGTCGTTCGGCTCCTTGCTGAAATAAGGACAAGAGCATGCCTGGTCATGGCCCAGCTTTTA GAAGACAGCTTATTTTGTGAAGAATTCATACAACAATGTCCAGCAGCTGTTGAAGTTCTTAACCTAGTAGCCCAGGAATGTAGTGCTGGA GAGCGACTTGCAGTTGTGGAGGTACAGTGTGAACGGCTGAGGATGCTCTACCGGGACTGTGCTCGGCCCCCACCACCTCCTTTGCAGGCT GACCGAAGACAGCCCAAAGAGATTACTTGGAGCCCCTCGCGAGTGTTTCCGCCTGTTCGAGCCTGCATGTTCTCATCTCACCTTACCTCA GTCACCTTCCTGGCTGACCCCAGCGCTGGGGGAGGCCTGCCCCGGGGCACTTTTATCTATGCCACTTCACCACTGCCAGTTCAGGCCCCG TCTTTTTACTGGGAAATTGAAATCGTTTCCTATGGAGACACCGATGATGACACCGGACCCATAGTTTCCTTTGGCTTCACTACAGAAGCA GAGAAGCGAGATGGGGCTTGGACTAATCCAGTGGGCACTTGTCTTTTCCATAACAACGGCCGAGCCGTGCACTATAATGGCTCCAGTTTG TTACAGTGGAAGAGCGTTCGCTTAGACGTGACTCTCTCCCCCGGTGACGTGGCAGGAATTGGCTGGGAGAGAACTGAGGGGACTCCACCT CCTCCGGGACAGCCAGCCAAGGGCCGGGTGTACTTCACATACTGCGGGCAGCGCCTCTCACCATATCTTGAAGACGTCTCTGGTGGCATG TGGCCAGTGGTTCACATTCAGAAAAAGAACACCAAAACCCGAGCTAACTTTGGCTCCCGGCCGTTTGCCTACGCGGAAGGGCAGGCCCAC CGCAATGCTGCTGACCTGTGCACTGACCTAGCAGAAGAGATCAGCGCTAACTTTGAGGCCCTGCCTTTCGCCATGGCATCTGACAGTGAC AATGATGCTGGCACCAGTATTGCATCAGACCCAGGCACTCATGGGCCACCATGCCGGATTGCTGCCGTGGCCACCGCTCAGCAACAATAT GATAGTGACACCTCCTGTCATTATAAAGTCGAGCTCAGCTATGAGAATTTCATCACCTCTGGCCCAGACCCTCACCCGCCTCCCATTGCA GATGATGAAAGCGATGATGATGACGATGATGACATCCCTCAGGAGGACCACTACGCCCTGCTGGTGAAAGCATGGGAGACCAAGGTTTTT CCTACCATCCGAAGACGCTTCCGCAATGAAGCAGAGCGGAAATCGGGCCTGGACCAGATAAAGGGGGCCTTACAACTAGGTATGGTGGAT ATTGCCCGACAGACGGTTGAATTTCTCTACGAAGAGAATGGTGGCATCCCAAGAGACCTTTATCTTCCCACCATTGAAGACATTAAAGAC GAAGCAAACAAGTTCACAATTGATAAAGTTCGAAAAGGTCTCACAGTAGTAACCCGCTCTCCAGACAGCAATAATGTAGCCAGCAGTGCT GTTGGAACTGCTCTGCCAAAATTTGCCATCCGAGGGATGCTGAAAACCTTTGGGCTTCATGGAGTCGTCTTAGATGTTGATTCAGTGAAT GAACTGGTGCAGGTAGAAACGTACCTCCGCAGTGAAGGTGTGCTGGTGCGATACTGGTATCCTATTGACATGTTGGAAAGGCCCCCAGCA GGCTACCGAAGGACTGCCACCAATGGGCTGGTCACACTGGACAATACCAACCTTCAAATTCACAGGGAGCTGCTGCGCTGCGAGGCTGCG CTGGCCAGGCTGTACTGCCGCATGGCCCTGCTCAATATCTTCGCCCCGAAGTTGCCTCACTTGTTCACTCGCCTCTTCCACATCCCTGCC ATCCGGGACATTACCCTGGAGCACCTGCAACTGCTGTCCAATCAGCTCCTCGCACCTCCTCTCCCAGACGGCACCATCAGCTCCAGCTCG ATCCTCCTGGCGCAGTCTTTACAGCATTGCATCCATTCCCAGAACTGCTCCGCCACGGACCTCTTTTACCAGGGCAACTCCCAGACAGTG AGAGAGTGGCTCAACGTGGCCATCACCCGGACCCTGCACCAGGGCGAGGAGAGCCTTTTAGAGCTGACGAAACAGATCTGCTCTTTCCTG CAGACAGCACCAGAGCAGTTCCCCTCCGAAGAGTTCCCAATTTCCGAATCCAAAGTCAACATGGACGTGAATTTCCCCGGGGCAGCTTTT GTTGTTGTGTCTTGTAAAGAAAGTCAATCTGGATTCCGCAAAGACTCCTCTCTGTACAAGGCACCGTGGGCACGGGTGCTCGTATATGGC CTCGGCCACAAAGTGAAGCGAAATGGCCAGCTGAACCTCATCGAGGCCGCCTGTTACCCGCGGGACGCGTCCCCAGCCAACACTGGGCTT GCACCTCCCCCCACCGCTGACCAGTACCCCTCTGTGGTCCTCTCCACAGACAGGGTCCACATCAAACTGGGGGTGTCTCCACCTCCTGGA GCAGTCCTGGTGTTACATTCCCTGCCCCTGGAGTTCCCACTGGCTATGGCCTTCGCAGAGCAGCTGCTGTCCTGGAAATCAGAGGACAGT GAAGGGAAGTCCGAAGATGAGCCTGACACCATTCCGACATCCGTCCTCCTGCAGGTGGTGGAGCTGCTAGGAAACTTCTTGTGGACCACG GACATGGCAGCCTGCGTGAAGGAGCTTGTTTTCCATCTCCTGGCAGAGCTCCTGCGCACGGTGCACACCCTGGAGCAGAGGCGGCACCCC GCTGGCCTGTCCTCCTCAATCGCCCTCCAGCTGAACCCCTGCCTGGCCATGCTGATGGCCTTGCAGTCGGAGCTCCACAAGCTGTACGAC GAGGAGACGCAGAACTGGGTCTCAGGCGGCGCCTGCGGGGGCTCCGGGGGGGCGGCGGCCGGTGACCAGGGCAGGTTCTCTACGTATTTT CATGCACTCATGGAAGGGTGCCTGGCTGTGGCCGAAGTGACCCTGCCTACTAACATGAGTGTCACAGCCAGTGGGGTGACCTCAGCGACC GCCCCAAATCTCAGTGACTCGTCCTCCTCCTCCTCGTCCTCCCCAGGACAGACCCCACAGAGTCCCAGCCTCCTCTCCAAGAGGAAAAAA GTCAAGATGAAGCGGGAAAAGGCCTCCTCGTCGGGCAAGCGCCAGTCTTCCCGCACCGTGGACTCGGACCCCACCGTGCTCAGCATCGGA GGCAGCAAGCCCGAGGACATGCTGTGGTTCCACCGCGCACTCACCCTGCTCATCATCCTCCGCCACCTCACCAGGAAGGACCCACAGGGG CTGGGCGTGACGAGTGACGCCATCGCCGATGCCTGCCAGGCCCTGGTGGGCCCCACCGCCCACAGCCGCTTGCTGGTGATCTCCGGGATC CCCACCCACCTGGACGAGGGCGTAGTCAGAGGCGCCATCCGCAAGGCCTGCAACGCCCACGGCGGGGTCTTCAAAGACGAGATCTACATC CCGCTGCAGGAAGAAGACACCAAGAAGCCAAAAGACAAGGCCGAGGGCGGGGACGGGAAAGTTGAGCCCGAGAAGACACTGGCCTTCCCC GGCACAGACAGCATGGAGGTCAGCACGTCCAGCAGCCTGACCCCCGCCATGAGCATCAGCGCCTCCGCCTCCACCAGCCAGGCCTCCATC TGCAGCTCGCAGGGCATCTCCCAAACCGTCAGCGACCTCTCTGTGGATCCGCTGCCTGCCGGCCTCGAGCTGCCCATCCCTCCGGGCCTG TTGGAGCCCCACGCGGTGTCCAGCCAGGAAAGCCTGGACATTTCCCTGTGCAGCACCGGCAGCCTGGGCAGCCTGGGCAGCCTGGGGGAG CCCCTGGACAATGCAGAGACGGCCTCGGTGTCGGACATGGGCTCCATGTACACAGTCACTTCCCTGGACAACCAGCCCCTCGCCGCCCGC CCCATCAAAGGCTTCGCAGTCGTGGAGATAAGATCCCGAGCCAAAATTGAGAAAATTCGAGCAAGTTTATTTAACAATAATGACTTGATT GGTTTGTCAAGTTTGGATGGTGAAGATGAATTGATGGAAATGTCAACAGAAGAGATTCTAACCGTGTCTGTAGTAAATCAGAGTCTCTTT GATACTCAAGGGAGCCCAGGGTTAGAAGATTATTTCAATGATAAGTCAATTAAAGGGGAGAAGCTGGTGCCCGGAGCCAGAGAGGTTCTG ACGGAGATATTTAAGAGTTGTGCCCATTCAGAGCAGACGCTGAGCCTGACACCAGCGAAGCCCATCAGAGTCTCTGACATTTATCTTAGC AAAGAGCAGATCAACTCCCAGACCCCAGGCAACCTCCTCCACCTCTTCTTCACCAATGTCCGGCCGCCAAAAAAGGTGCTGGAGGATCAG CTCACCCAGATCCTGAGGAAGTATGGCGTGCCAAAGCCCAAGTTTGACAAGAGCAAGTACAGCAAGGCCGGGAAGGAGCAGCACCCCGTG AAGGTGGTGAGCACCAAGCGGCCTATCACCAAGCCGCCCGCCAAGGACAAGGCTGTGCTCAACAGCGTCAGCAGGACTGCCTTAAGTGAG AAGAAGCCAACTGTGAAGCCAAAATCACCAGAAAAGAGCAAACCAGATGAAAAGGACCCAGAAAAGTCACCTACCAAAAAACAAGAAGTC CCTGAGGAAAAATACCTGACGCTGGAAGGATTTCACAAATTTGTTATTGACCGAGCCAGGCAAGATATCCGTAGCGTCTGGAGGGCGATC TTGTCCTGTGGTTACGATCTTCACTTTGAGAGGTGCGCATGCATCGATGTCCGACATGCACAGAAGGCCTCAAGAAAGTGGACCCTGGAG ATGGACGTGGCACTTGTGCAGTACATCAACCAGCTATGCCGCCACCTCGCCATCACACCCGCACGGCTCCATCCCCATGAGGTGTACCTG GACCCCGCGGATGCTGCTGACCCCAGAGTGGCCTGTCTCCTGAACGTGCCCATCGAGAGCCTGCGCCTGCGCTTCGCCTTGCTGCAGTCC CTCAACACCACACTGGAGACCTTCTTCCTGCCCCTGGTGGAGCTGCGCCAGACACCCATGTATACCCACAGCATCGCCGCCCTGCTGAAG GAGGCCAAAGGGCTGATCTTCTATGACACGAAGGTGACCGTGATGAATCGAGTGCTGAATGCCACTGTGCAGAGGACAGCGGACCACGCG GCCCCTGAGATCACCTTGGACCCACTGGAAATTGTGGGAGGGGAAATCAGAGCTTCTGAAAACTCCTACTTCTGTCAGGCTGCCAGGCAG CTGGCCTCAGTGCCGTCGTCTCAGCTCTGCGTCAAGCTGGCCAGTGGCGGTGACCCCACATATGCCTTCAACATCCGCTTCACTGGCGAG GAGGTCCATGGCACCAGCGGCTCTTTCCGCCACTTCCTGTGGCAGGTGTGTAAGGAGCTGCAGAGTTCCTCGCTGTCGCTGCTGCTGCTG TGCCCCAGCTCAGCTGTCAATAAGAACAAGGGCAAGTATATCCTGACCCCGAGCCCCATCACCTACGGGGAGGAGCAGCTGCTGCACTTC CTGGGGCAGCTGCTGGGGATTGCAATTCGGGCAGACGTCCCGCTGCCCCTGGACCTCCTGCCCTCCTTCTGGAAGACGCTGGTGGGCGAG CCCTTGGACCCTGAGCAAGACCTGCAGGAAGCGGATATCCTCACCTACAATTACGTCAAGAAGTTTGAGAGCGTCCTCATCCTATAGCCC ATCGCCTGTCAAGAAAAAGAAGAAGAAAAGTTCCAAGAAACACAAGCGACGCAGGTCATTCTCCAAGAAGAGAAGGCACAGCTCCTCTAG CCCAAAAAGCAAAAGAAGAGATGAGAAGAGGCACAAGAAACAATCTCGAAGCCGGCCCCGAAAGTCTCACCGCCACCGCCATCACCGCTG CCCCTCGCGGTCCCAGAGCTCGGAGTCCCGCCCCTCAAGCTGTGAGAGCAGGCACCGCGGCCGGTCCCCTGAGGAAGGGCAGAAGTCCCG CCGAAGGCACTCCCGCCGCTGCTCCAAGACCCTCTGCAAGGACAGCCCTGAGGCCCAGTCCAGTCGCCCGCCCAGTCAACCCCTCCAGAT GCTTGGCTACCTGTCAGCCAGGGGTGTAATCACTGGGTCGGGGTCTGCTGCTGACCTCTTTACCAAAACAGCCAGCCCGCTCACCACCTC GCGAGGACGTTCCCAGGAGTACGACTCAGGAAATGACACGTCCTCGCCACCCTCCACGCAAACCAGCTCAGCCAGGTCTCGGGGCCAGGA GAAGGGGAGCCCCAGTGGGGGCTTGAGCAAGAGCCGGGAGCTCAACAGTGGCAACACCTCTGATTCAGGGAACTCCTTCACCACCTCCTC ACCCCAGAACAAGGGGGCCATGTTGGAGAATCTCTCCCCCACCAGCAGGGGCAGAGAGTCAAGGGGATTTCAGTCACCGTGTCTGGAATG TGCCGAAGTGAAGAAGTCCAGTTTGGTCCCATCCACAGCCCGGAGCTCACCCATGAAAGGGTGTTCCCGCAGCTCCTCCTATGCCAGCAC CCGATCCTCCAGTCACTCGTCCCGATCCCCAAATCCCAGGGCTTCCCCCAGGTACACCCAAAGCCGATCCACCTCTTCTGAAAAAAGGTC CTACTCCCGCTCTCCCAGCTATTCCTCCAAGTCTGGCAAGAGGAGCCCGCCCAGCAGAAGCTCTAGGTCCCGCCGCAGCCCTAGCTACTC CCGCTACAGCCCCAGCAGGGAGCGGGATCCCAAATACAGTGAGAAGGACTCGCAGCAGCGGGAGCGCGAGCGAGCGCGTCGGAGACGTCG GTCCTACTCGCCTATGAGAAAGCGCCGGAGAGACTCCCCGAGCCACCTGGAGGCCCGGAGGATAACCAGTGCCCGGAAACGCCCCATCCC CTACTATCGGCCCAGCCCCTCCTCATCCGGCAGCCTCAGCAGCACCTCCTCCTGGTACAGCAGCAGCAGTAGCCGCTCGGCCAGCCGCAG CTACTCCCGGAGCCGGAGTCGGAGCCGGAGCCGGAGACGGAGCCGGACCCGCACGAGCAGCAGCTCTAGCTCCCGCAGCCCTAGTCCGGG CTCCCGCAGCCGGAGCCGGAGCAGGAGCCGGAGCCGGAGCCGGAGCAGGAGCCAGAGCCGGAGCTACAGCTCAGCAGACAGCTACTCCAG CACGAGGCGCTAAGTGCCCCTGAGCCAGCTGCCCGTGGGGGCCCCTTCGCGCTGCCAGCCTCCCCCAACCACCTGCCCTCCCCGCCTTCT TGGTGACAAATAGTGAGGGCTCCTATACCTTGTCCTTCCTGCTTGCCTAGGGGAAGAGGAGAAGAGGGTAAGGGGGCTTCACTCTCTAGA TCAGCCTGCTAGGAGCCTCTACCAGCATCATCCTGGGGCCCAGCTCAGGCCTGGGCATATGGAAAGAACCATCATCTTGTGGCACAAAAA AAGAAGAAAGAAAAGAAAACTTCAAGGTTTTGTGAGAAGCAATGGGTCTGTGACTCAAAAATTGAGCCCTGGCCAGGAAAATGTGGAGAC AGTTCTTCTCCTCCACTGCTCACAGGAGGCCCGTGGTAATTCTCCCCACCTCCCCGGATGCCCCACTAGTCCAACTTCATGGCTGCACGT GGATGGACCCCCATGTCTGAGAGGGGTGAAAGAGGAGACCAATGGCAGTTCAGGTTCAAGATAACGGGGTCAGGCCTTTAACTTCCTCAA ACAGGCCCAAGCAAAGGCTGGAAGACATTTGGGTCCTAGAAGAAGGGATATCCTTGAATACCAGATGGGGACGTTTGACTTGGTGGGAGG TGTCAGGAGATAGGAGTTGGTTAAGATGATAGATAGAAAAACGGAAGGGTTCAGCTGCTGCTCCCAATACCTCAGCATGGTAAGGGGACA GAGCCCAGCAGATCCCAGCTGTGAAGAGGCCACTGCATGGCTGACACAAAACACCTCTTGGCCATTCACAGGGGCCCTGCAACCTCACGA GAAAGGAGATAGTGGAAGAGTCAGGACAGGTTGGTCTCCAGCCCCACTTCCCAAATATGCCTCAGCCCCACTAGCTGGCACCAACTTAAT TCCACGGGACCATCTGCTGAACATTCCCCAGTGCCATGGCCAGTTGCCAGGCCCCAGCGCCAGCCAGTCTGGCCTTACCCTCCGGTTGGC GCCTGCCAGCCCCCTCCCCTCTGCCCAGGCTGCCACGCCCTGGATGCCACCCAGTGCAGCCTGGCACCTACCCACCCACCCTTCAGCTTA AGCCACTCCCCTTGCCTCTCAGGAATTTTGCCAGGATGGGGCACAGCAGCTCAGGTTTGGGGGAAAAGACCCGAATCCAGAGTGCAGGGG AGAGGGGCTTGGATATGCCATGTCTTGGGCTCCTGCTGGCTTCTGAGGTTTCTTGTCAGCTTGGGAAAGACCCACCTTTATTTTTGCCCT CACCCCAAGTCCCCCCTGGCTGGGGCTGGGCAGAGAGGGTAAGCTGATCTCCGATCCACAAATACCACCAGCTGCTTCATCCACAGAAGG CGCTAAGAACGGGGAGGTGAGGAATAAGATCCTTAAAATAAACTCTTGGGCATCCCCCTCACCAGCTGACTGGCTTTCCGGAGGCTTGTG GGTGAGTTTCAAGTTTGTGGTGGCAACAGCAGCAGGACAGGGCACGGAGGGAGCGAGGGAGAGAGGACCGGTCCCAGCTTTTGGATATTT TGGGTTATGGGGAAGCAAGGGCCAAACATTCTTTATCCCTCCCACCCCAGGGAAAACATTTGGAAAATAGTCCTTTTTCTTGGAAGCAGT GACGTCTCCCTACCCAATCTTTCCCATCCTATCAACCCATGGGGCTAGAGACTGCCATGCAACCACCACCACGACAGCCCTTCCTCCATC AGAAGACAGGAGTGAGGGCCCCGGGCAGCAGTGGACGACCCAGCCTCCCCATACCGGGCCTCTGGCCCAGACCTAAGCCCTGCCCACAAA GACTAATGGATGCCAGTGCTGTCACTGCAGAAGGCCAGATGGCAGGTGCCTGGGACAGGGGCAGGTGCCCCGGGGAGGGCAAGTACAGCC ACTGTAAATAACCCTCGTCCCTGCCCAGGAACCCAGACTGGACTTCAGTCTCCCTCCATGGAGACAAAGGCTTCCCAGAGCCACCAAAAA CCTTCTTAGCAGGACAGCTGTGAGAGGCATCAGAACCTCACGTTCGGACTGCCTTCATCAAGACAACTCTAGGGGACCATTTTGCCTGGG GCTCCTAGCAAACCTTTTTATTTATTTTATTTATTTATCTATTTATTTATTTGATGACTGTCTCTCTTTCTCGCCATTAGCAGTATTGAA TTATTTATTTATACAGAGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGGGGGATCTCCTAAA TTATTTCTGTGCATCTCCTTTTTTTTTCTGCTGTTTTTTATGGATGGGATTTGAGAGGCCAAAGGTGAGTGGGCTATTGGCCTTCTCCCT GAAGGCTCTAAGCCTGGAACACCCTGGGGTTGGCCCAGAAGGAGGCACATCAGTCCCAAAATTCATCACTTAACCCAGCGTCCAGGAGGG TCAGGCCTGTACCCCAGCCTCCTGTCCCCCAGGAACCTCACAGGGGTATCAAAAAGATGTAAACAGCCCAGAGGCTTATGAGCTACAGTG ATGAATTGACACAGTGGAGTTGCAACTTAGGTGGGGGTTGGAGTCGAAAGTTGGCAAATGGGGCCAAGGCTGCACAAAGTCGAAATCCCT TGTGAATGTCCCTTAGGGAGGCACCAGATTGGAGACAGATGTGCTATCTCCTAACAGAGTGATGAGGCTTCAGTTGAGTACTTGCTGAAG TAGTTGCCTTGTATTTTGAGGGCCATGGTGGATGAAAATGATGTCTGGTTTAGTACTGGAATTGCACTTGGGGTTGACAAGGTGCTCACA CCATGAGAATGGAGGCAGGAATTGAGCTGACTGAGGGAAGATGCACCTTGATCTCACCCTCACTCCAAGGCACATAGCAGGATCACTCCC TAGCTTCTCTGAGCACACCTAGTTGGTTTCATGTATGTTACACATGCTTCCACTCCACAGTACCTAATTTCTCTCTGTCCCCTGAGATCT GAAGGCTACCTTGGGAAGAGGCATCAGCCATCTTGCTTGAGAACCACCAAGCCAAAAGCAAAAGCTTTTATCTATGATCTCTTGCTGTTT CATCAGGGGAAAGCACAAAGCTATTTCTGAAATTAGGAAAAAAAAAAAAAAGGTGGAAGGAGCAGCCAGATGTTCCACAGGACCCCACCA AGAAGGTCATTTCCAAACCCATCCTGGAAGGGCCCAGGATCCAAAGGTCATCAGTCCTGCTTATCTGACCAACTGGCAGTGTCTTCTGGC TGCTGGCCGGAGACAGCTCTTGCCCTTTCCAAAGTCACTGTCCACTGCCTTGCAATTGCCAGCTTGTCTGGTCCAGCTTTGGGTTTGGTG AGACTTTTGCAACATCCCTGGTTGTTTCCCTGGCAATGTGACTATCCAGCCCTAACCCAAAGCAAGGGAGTGCCCCTTTCCTGGGTGAAG TTTACAAGAAGGCTGCTTAAATGCCTGCTTCGGGGAAATCTCTGCCTCTCTCTCTCTCTGTCTCTCTCTCTGTCTCTCTCTCTGTCTCTC TCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTGTATTTCTCTACTTTCTTTTACATTTCCTTTTTTTCTATCCAAAAACAATGTGCTTGTT GAGGCACTGGTAACCCTGATTAACCAGAACCTCCCATTCCCAGTATCGCTGTTCCTACGCCCATTTCACCCTCATTACCTTCTGCTTCCA AGGAATATGACAGATCACCAGGATGCTGCTCGTCGTGAGGATTTATCTCAAAAACCAACATCCAAAATGGGAGGGAGATGTGGCTTGAGG TCAAGCGCCATGCATCCCAAGCCTTTGACCTTCCCGCTATGGAAGTGCACTGGATGACAGAAACTGAATACATTGCTCCCTTTCCCTAGG GCAAAGTTCGACCTCTGTTAAGTGGAGGGATTTGTGAGATAAAAATTCAAAATGTTGGCCTGAGGCCTGAGAGTGTCACCAAAGACAGAG GGAGCTTCACTGAGACTCAGAGGGAAAAGGAAAAGAGCCTCAAACATTTTTAGGAGGTTGTCCATCATGAAAGTAAAAACGAAAAGCAAG ATTTGATCTCCCTTCAGTTAATTAGGCAAGGCTAAGTAACTCAAAGCCCCCTATTAGTAACATTCTGGTTCACTGAGGTTTGATCATATT CCTATCTGCATTCCTTCCCTTCTTTGAAGGACAGCTGATCTTTCAGAAGCAGAATAAAATTAAGATGTTAGAACAAAGGTCTCAGTCTCA GAGAACCGCATCACTTCATTTGCTCAGACCCATCCTCTTTTGCAAAAGGGTCTGCTTGGAGAGGCCAAAATTCAGGGTGCTCTCAAAGGC AAAGAAAGCACATTGTTTTCCTTCTCCAGTCCAACTTTCATCTTTTCTTCTGCTGTTTTCTTTTCCCCTCTTCTTTTTCACAAATGTTCA AAATGGTCTCATGCGCATGTGTCTTGCCCCACTTTCCCCTTTAGCTGAACAGAAAATTTTGTCTCAGTAAAACGAAGTCAAAAAACAGGA TTCCTCCAAACATGCCTCCTCCCGCACTGGCCAGCCGAGTCCAGCTGAGAAACTTATGCTAGATTCAATGTCATTGAGCAATGCTTTATT GAAGTCTCGTTCTTCTCACTTCTGCACCAGTGAGCCAATGATACTGACAGAAATGTCATCTCTCTTCTATCTGTGGTTGCTGTTTTTGGA GTAAAAGTTTCTGTGTGTGTTTTTTTAGTTCTTTTGATGGCTGTTGTTTTGCATTGTAAATACCATGATGGGGGACCCCCATCAGAACAT GGCTTATTTAATAATTTATTTCGTATTTATTGAGTAATATTGGGAAAAGAGAAGGACCACCTCTTTCCCTGAATTGCTATTGAGAATTGG TCCATCTCCCAGCTCCAGGTGCTGCTGTCTGCAGCAAGGGCATTACTGCCCAGGTAAGGAGTGCTAGAATCACCAAGCAAATTGAAATTG GCAGAAATGGAGGCTTCAGTCACACAAATTAGACTCAAATGGAACTAAAACACTGGTTATCTCCAGGAAAACCTCATTTAGATGGAAATT AATGGAAGAATAAAATGCCTACACATGAACCAACTTCTATTAAAAAGTCACAACTCCTTGAAAAAAAAAATAAAGAAAAATTGTAAACTC TTTTTTTTTTCTGGCCAAGGAAAGCTATGCCTCATCTTCTAACGAGCCAAGCCAAAAAGACTGCAATGGTATTCCTATGTGTTTCTTTGG CCTGTGTATCAGTCTGAATGAAATGGAATGGGTCTCTAGCCTCAGTCTTGTCATCTGTAAAATGGGGCTTGTCCTATATATTATCTGCAA GACGTGGGAAATGGGGGCTCAAGCCCTGATGCTATGGACTCCATACTGTTGGATATATTGTCTCTTGTGTCTTCTGCTGACTGCAGATTA AAGGGTGTCAACCAAGGAAGGAAACAAAAAAGTAGGGCCTGGACTTCATTTGCAGAATGAGGTCATAGTCGTTGAGTCCCACAGTCATAT ATGGGAGACCTCAAGTTGCTGTCACCTTGATAACTCTTGTATCCTGGGTTAAAGCCCTCTGTATTTAGTTTGAACTTCTCTCTAAGCCCC GTGGTCCAAAGTCATCACGGGAGAGACCAAGATGGGCTTACCTTGCCCTGCTCTGGATTTAACCATTGTTCATTGTCAGGCTATATTTTT GTACAATCATTCAAATAACCCAGTGACATAGGTCATATTGCCACTTTTCAGAGGAGAAAACTGAGGCTCAGGAGGGGGAGTTGACATGCC CAAGCTCCCTTGAGCTCAGATCAGCTTGACTCAATGTCCAACATTCCCTTGGTAGCTTTTTCTCCGGGGTCCTGTGCTATAAGAACTTCT CTCTGCACTGTATTTTTTTTTCTCCCAATTCTTAGCTATTTCCTCAAGCAATGATTGGCCAAGGACCTAGCATAATCCACCACATTGGCC AAGGGGACGTGGTGCACCCCAAGGCCATTTCTCTGCATTGGAGGCTGCGAATCTCCTCTGGAAAATTCCCAACCCGAGGACCCACCATGA GCCCAGCTCAGCCTGACCAGACAGCCTCTGCCTGGAGCATTCACATCAGATGGAAAGAAGCTGCTGTGTCCTCCAGCATCCTGGGACCCT GTCCTCTGCCCAGTGACACAGCAGCCATGGCTAGCTTGATTTCTGGTCTCCAAAGCTAAGCATAACCTTCCCGGGGTTTCTGGTTTTTCA >36048_36048_2_HECTD4-SRRM4_HECTD4_chr12_112605121_ENST00000550722_SRRM4_chr12_119554742_ENST00000267260_length(amino acids)=4151AA_BP= MHDGLIRVTDLAELPSEILGAPEAADTDLEILTFETKNPSELAERLRSVCGNQSNAYARLLEYRLNALRGLWNAQRQLALEEQHERESSG DEETLALLKRQGLLQQPEQAPFTSRMGLLLVFPLIQSQSRTDPSLCNITAEVLLNCLRDCQPLSLTKEPADCLNGIETLLCSWLEETSDT GRHIPHKQKENAAAALVALACARGSLKTFVHTVHLLQKQTDLGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIVSWGYEDMLPAPDSNTG SSSENKDADLGRCLTADGLYLYTTNSVGRGVSKLGSGLHGTLRGFVYCRNEELEPGWVAFGSGSLLHRPVSFDNKPHSLFQVIDQNTLQV CQVVPMPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESAKSINEMLLS RLSRYRASPSATLAALTGSTISNTLKEDQAANTSCGLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKILASSLV YNISDGQFTSRADLIDAAGSSLGRGALVPGLGACYDTVNNMLWTCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQ LLHHVGAMCIHQLNLLATNPNLPITSVLGKQHPIEAHHLSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFFSPQTERNRDIIRRSGLL LWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLKLVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELL HYILKIVVRESCILITKCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGETLKELKVSILALATQILT GCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTKATMLGHLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVF AEVGCSPCGAPDQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARCLYLRFDSRCSSQYDYDKLV IYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLA LGLSVLACSMLRILYNGPEITKEEEACQELLRSKLLQRCQWQVEANGVISPALTPSPSPLPLTIEEDREFTYPSDVLVPPVGNYFDLPRI RLPPGIMIKLREISGRARPQFRPSIKEVIQPDVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQ SVAELEQKWQSEVDDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENMVLSLREKFLQEVNSLIQKPSHPLAKTKTLV KSLMNRAELLLHVTIAAQSGLTRSISGTPAETPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSS FTLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQGG PRIEELTCGGMVEQVQEAFGETMTSVVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKV ATMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLTNHLARATECCGNQAAGNDALQDVLSLLNDLSRSHIGKAILSQPACVSK LLSLLLDQRPSPKLVLIILQLCRAALPLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEP DTTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLGTGANMEKVVKMDRDMTKGGCCEVITEEAA AALRKATKWAQSGLIVSIGPPVESINPETVSGLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESN AAQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINE QEGIATVRFPPIDCRKTSQASDTLTIPLSRLCVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAE IRTRACLVMAQLLEDSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFP PVRACMFSSHLTSVTFLADPSAGGGLPRGTFIYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFH NNGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLSPYLEDVSGGMWPVVHIQKKNTKTRANF GSRPFAYAEGQAHRNAADLCTDLAEEISANFEALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENF ITSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLDQIKGALQLGMVDIARQTVEFLYEENGGIP RDLYLPTIEDIKDEANKFTIDKVRKGLTVVTRSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVR YWYPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHIPAIRDITLEHLQLLSNQLL APPLPDGTISSSSILLAQSLQHCIHSQNCSATDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISES KVNMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAACYPRDASPANTGLAPPPTADQYPSVVLSTD RVHIKLGVSPPPGAVLVLHSLPLEFPLAMAFAEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHLLAEL LRTVHTLEQRRHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQNWVSGGACGGSGGAAAGDQGRFSTYFHALMEGCLAVAEVTLPT NMSVTASGVTSATAPNLSDSSSSSSSSPGQTPQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTLL IILRHLTRKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEGVVRGAIRKACNAHGGVFKDEIYIPLQEEDTKKPKDKAEGG DGKVEPEKTLAFPGTDSMEVSTSSSLTPAMSISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLC STGSLGSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDELMEMSTE EILTVSVVNQSLFDTQGSPGLEDYFNDKSIKGEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFF TNVRPPKKVLEDQLTQILRKYGVPKPKFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKAVLNSVSRTALSEKKPTVKPKSPEKSKPDE KDPEKSPTKKQEVPEEKYLTLEGFHKFVIDRARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLA ITPARLHPHEVYLDPADAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQTPMYTHSIAALLKEAKGLIFYDTKVTVMNR VLNATVQRTADHAAPEITLDPLEIVGGEIRASENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVC KELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HECTD4-SRRM4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HECTD4-SRRM4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HECTD4-SRRM4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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