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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:HECW2-PALLD (FusionGDB2 ID:36058)

Fusion Gene Summary for HECW2-PALLD

Fusion gene summary

Fusion gene information	Fusion gene name: HECW2-PALLD
	Fusion gene ID: 36058
		Hgene	Tgene
	Gene symbol	HECW2	PALLD
	Gene ID	57520	23022
	Gene name	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	palladin, cytoskeletal associated protein
	Synonyms	NDHSAL\|NEDL2	CGI-151\|CGI151\|MYN\|PNCA1\|SIH002
	Cytomap	2q32.3	4q32.3
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase HECW2HECT-type E3 ubiquitin transferase HECW2NEDD4-like E3 ubiquitin-protein ligase 2NEDD4-related E3 ubiquitin ligase NEDL2	palladinmyoneurinsarcoma antigen NY-SAR-77
	Modification date	20200313	20200313
	UniProtAcc	Q9P2P5	.
	Ensembl transtripts involved in fusion gene	ENST00000260983, ENST00000409111,	ENST00000507735, ENST00000261509, ENST00000333488, ENST00000505667, ENST00000512127, ENST00000335742,
Fusion gene scores	* DoF score	3 X 3 X 3=27	17 X 16 X 5=1360
	# samples	3	18
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(18/1360*10)=-2.91753783980803 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HECW2 [Title/Abstract] AND PALLD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HECW2(197297856)-PALLD(169798874), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across HECW2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PALLD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-8209-01A	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+

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Fusion Gene ORF analysis for HECW2-PALLD

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000260983	ENST00000507735	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
5CDS-intron	ENST00000260983	ENST00000261509	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
5CDS-intron	ENST00000260983	ENST00000333488	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
5CDS-intron	ENST00000260983	ENST00000505667	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
5CDS-intron	ENST00000260983	ENST00000512127	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
In-frame	ENST00000260983	ENST00000335742	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
intron-3CDS	ENST00000409111	ENST00000335742	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
intron-5UTR	ENST00000409111	ENST00000507735	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
intron-intron	ENST00000409111	ENST00000261509	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
intron-intron	ENST00000409111	ENST00000333488	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
intron-intron	ENST00000409111	ENST00000505667	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+
intron-intron	ENST00000409111	ENST00000512127	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000260983

HECW2

chr2

197297856

ENST00000335742

PALLD

chr4

169798874

4735

475

452

2662

736

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000260983	ENST00000335742	HECW2	chr2	197297856	-	PALLD	chr4	169798874	+	0.002649422	0.9973506

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Fusion Genomic Features for HECW2-PALLD

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HECW2	chr2	197297855	-	PALLD	chr4	169798873	+	8.29E-05	0.99991715
HECW2	chr2	197297855	-	PALLD	chr4	169798873	+	8.29E-05	0.99991715

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HECW2-PALLD

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:197297856/chr4:169798874)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HECW2 Q9P2P5	.
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269\|PubMed:12890487, ECO:0000269\|PubMed:24163370}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

563_567

1812.3333333333333

Compositional bias

Note=Poly-Pro

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

634_864

1812.3333333333333

Compositional bias

Note=Pro-rich

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

563_567

272

1002.0

Compositional bias

Note=Poly-Pro

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

634_864

272

1002.0

Compositional bias

Note=Pro-rich

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

563_567

1113.6666666666667

Compositional bias

Note=Poly-Pro

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

634_864

1113.6666666666667

Compositional bias

Note=Pro-rich

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

563_567

673.0

Compositional bias

Note=Poly-Pro

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

634_864

673.0

Compositional bias

Note=Pro-rich

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

563_567

778.0

Compositional bias

Note=Poly-Pro

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

634_864

778.0

Compositional bias

Note=Pro-rich

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

1001_1085

1812.3333333333333

Domain

Note=Ig-like C2-type 3

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

1135_1226

1812.3333333333333

Domain

Note=Ig-like C2-type 4

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

1233_1324

1812.3333333333333

Domain

Note=Ig-like C2-type 5

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

271_360

1812.3333333333333

Domain

Note=Ig-like C2-type 1

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000261509

440_539

1812.3333333333333

Domain

Note=Ig-like C2-type 2

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

1001_1085

272

1002.0

Domain

Note=Ig-like C2-type 3

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

1135_1226

272

1002.0

Domain

Note=Ig-like C2-type 4

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

1233_1324

272

1002.0

Domain

Note=Ig-like C2-type 5

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

271_360

272

1002.0

Domain

Note=Ig-like C2-type 1

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000335742

440_539

272

1002.0

Domain

Note=Ig-like C2-type 2

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

1001_1085

1113.6666666666667

Domain

Note=Ig-like C2-type 3

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

1135_1226

1113.6666666666667

Domain

Note=Ig-like C2-type 4

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

1233_1324

1113.6666666666667

Domain

Note=Ig-like C2-type 5

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

271_360

1113.6666666666667

Domain

Note=Ig-like C2-type 1

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000505667

440_539

1113.6666666666667

Domain

Note=Ig-like C2-type 2

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

1001_1085

673.0

Domain

Note=Ig-like C2-type 3

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

1135_1226

673.0

Domain

Note=Ig-like C2-type 4

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

1233_1324

673.0

Domain

Note=Ig-like C2-type 5

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

271_360

673.0

Domain

Note=Ig-like C2-type 1

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000507735

440_539

673.0

Domain

Note=Ig-like C2-type 2

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

1001_1085

778.0

Domain

Note=Ig-like C2-type 3

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

1135_1226

778.0

Domain

Note=Ig-like C2-type 4

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

1233_1324

778.0

Domain

Note=Ig-like C2-type 5

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

271_360

778.0

Domain

Note=Ig-like C2-type 1

Tgene

PALLD

chr2:197297856

chr4:169798874

ENST00000512127

440_539

778.0

Domain

Note=Ig-like C2-type 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000260983

847_874

1573.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000409111

847_874

1217.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000260983

1237_1572

1573.0

Domain

HECT

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000260983

167_301

1573.0

Domain

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000260983

807_840

1573.0

Domain

WW 1

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000260983

985_1018

1573.0

Domain

WW 2

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000409111

1237_1572

1217.0

Domain

HECT

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000409111

167_301

1217.0

Domain

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000409111

807_840

1217.0

Domain

WW 1

Hgene

HECW2

chr2:197297856

chr4:169798874

ENST00000409111

985_1018

1217.0

Domain

WW 2

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Fusion Gene Sequence for HECW2-PALLD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>36058_36058_1_HECW2-PALLD_HECW2_chr2_197297856_ENST00000260983_PALLD_chr4_169798874_ENST00000335742_length(transcript)=4735nt_BP=475nt
ATTTGAGCATCAGTTGAGGGAGAGGACGCTTCATTTCCTTTTTGGTTGGGAATGTGCCGTGAACATCCTCTGCTGGAGCTTGGGGCCTGG
AGCAAACTGGGGCTGCAGATTTAGACGTAGACGTTTCCGAGGACGCGAGACTGCAGAGCTTTGTAGGCAGCCAATCCCAGAGAAGCAGAC
GGGATGGCTAGTTCAGCCCGGGAGCACCTGCTTTTTGTGAGGCGTCGAAATCCCCAGATGCGGTACACATTGAGCCCAGAGAACCTCCAG
AGCCTTGCCGCCCAGAGCTCCATGCCAGAGAACATGACCCTGCAGCGGGCCAACAGCGACACCGACCTGGTGACTTCTGAGAGCCGCTCC
AGCTTAACTGCCAGCATGTACGAGTACACGCTGGGGCAAGCCCAGAACCTCATTATCTTCTGGGACATTAAAGAGGAGGTGGACCCCAGT
GATTGGATTGGACTTTATCATATAGGGACCCTCTGAAGCTCCAGCAACTCCAGAACCAAATCCGACTGGAGCAGGAGGCCGGCGCTCGGC
AGCCTCCGCCAGCCCCGCGCAGCGCGCCGCCCTCGCCCCCCTTCCCGCCGCCGCCCGCCTTCCCCGAGCTCGCGGCCTGCACGCCGCCCG
CGTCCCCGGAGCCCATGAGCGCGCTGGCCTCCCGCTCCGCCCCCGCCATGCAGTCCTCCGGCTCCTTCAACTACGCGCGCCCCAAGCAGT
TCATCGCCGCGCAGAACCTCGGGCCCGCGTCGGGCCACGGCACGCCGGCCTCCAGCCCCAGCTCGTCCAGCCTCCCGTCGCCCATGTCCC
CGACGCCGAGGCAGTTCGGCCGCGCCCCCGTGCCGCCCTTCGCGCAGCCCTTCGGCGCTGAGCCCGAGGCCCCGTGGGGCTCCTCCTCGC
CGTCGCCCCCGCCCCCGCCACCCCCGGTCTTCAGCCCCACGGCTGCCTTCCCGGTGCCCGACGTGTTCCCACTGCCGCCGCCACCACCGC
CGCTCCCGAGCCCGGGACAGGCGTCCCACTGCTCGTCGCCTGCCACCCGCTTCGGCCACAGCCAGACGCCCGCGGCCTTCCTCAGCGCTC
TGCTGCCCTCGCAGCCGCCGCCGGCGGCCGTCAACGCCCTGGGGCTGCCCAAGGGTGTCACCCCCGCAGGATTTCCAAAGAAGGCCAGTA
GAACTGCTAGAATAGCCTCCGATGAGGAAATTCAAGGCACAAAGGATGCTGTTATTCAAGACCTGGAACGAAAACTTCGCTTCAAGGAGG
ACCTCCTGAACAATGGCCAGCCGAGGTTAACATACGAAGAAAGAATGGCTCGTCGACTGCTAGGTGCTGACAGTGCAACTGTCTTTAATA
TTCAGGAGCCAGAAGAGGAAACAGCTAATCAGGAATACAAAGTCTCCAGCTGTGAACAGAGACTCATCAGTGAAATAGAGTACAGGCTAG
AAAGGTCTCCTGTGGATGAATCAGGTGATGAAGTTCAGTATGGAGATGTGCCTGTGGAAAATGGAATGGCACCATTCTTTGAGATGAAGC
TGAAACATTACAAGATCTTTGAGGGAATGCCAGTAACTTTCACATGTAGAGTGGCTGGAAATCCAAAGCCAAAGATCTATTGGTTTAAAG
ATGGGAAGCAGATCTCTCCAAAGAGTGATCACTACACCATTCAAAGAGATCTCGATGGGACCTGCTCCCTCCATACCACAGCCTCCACCC
TAGATGATGATGGGAATTATACAATTATGGCTGCAAACCCTCAGGGCCGCATCAGTTGTACTGGACGGCTAATGGTACAGGCTGTCAACC
AAAGAGGTCGAAGTCCCCGGTCTCCCTCAGGCCATCCTCATGTCAGAAGGCCTCGTTCTAGATCAAGGGACAGTGGAGACGAAAATGAAC
CAATTCAGGAGCGATTCTTCAGACCTCACTTCTTGCAGGCTCCTGGAGATCTGACTGTTCAAGAAGGAAAACTCTGCAGAATGGACTGCA
AAGTCAGTGGGTTACCAACCCCAGATCTAAGCTGGCAACTAGATGGAAAGCCCGTACGCCCTGACAGTGCTCACAAGATGCTGGTGCGTG
AGAACGGGGTGCACTCTCTGATCATAGAGCCAGTCACGTCACGTGATGCCGGCATCTACACATGTATAGCTACCAACCGAGCAGGACAGA
ACTCATTCAGCCTGGAGCTTGTGGTTGCTGCTAAAGAAGCACACAAACCCCCTGTGTTTATTGAGAAGCTCCAAAACACAGGAGTTGCTG
ATGGGTACCCAGTGCGGCTGGAATGTCGTGTATTGGGAGTGCCACCACCTCAGATATTTTGGAAGAAAGAAAATGAATCACTCACTCACA
GCACTGACCGAGTGAGCATGCACCAGGACAACCACGGCTACATCTGCCTGCTCATTCAGGGAGCCACAAAAGAAGATGCTGGGTGGTATA
CTGTGTCAGCCAAGAATGAAGCAGGGATTGTGTCCTGTACTGCCAGGCTGGACGTTTACACCCAGTGGCATCAGCAGTCACAGAGCACCA
AGCCAAAAAAAGTACGGCCCTCAGCCAGTCGCTATGCAGCACTTTCGGACCAGGGACTAGACATCAAAGCAGCGTTCCAACCTGAGGCCA
ACCCATCTCACCTGACACTGAATACTGCCTTGGTAGAAAGTGAGGACCTGTAATCCAGCATTCTTGTTAAAGCTGAAACACTGAAACAGC
CATTGCCTTGACCAACATATTCCTTTGTCACATTATGTAAAAGGCAGAAACATACCTTTGACTATAAGAAATTAAAAAAAAAACACCAAA
ATAATATTTTTCTTACTTGATATACCAAACTTAGTTTAAGTAGATAATGCTAATACAAATATACACATTGCACAGAAAATACACATTTAC
TGTCCAATTTAAAACTTTGGAATTGCTGTGATTAAAGTGATCAAAATGCCAAAATACTAAAGGAAATCAATTGTTCACAGGTAACTACAA
TTTGTATTATCTACAAGTGCCTTTAAACACAAGATATAGGTGCTGTGTAGCCTGATAGTGTGAAATGTTTAATGAGGGAGTTGTACCACA
AACAGTACTACAATGATTCTGAAGCACAGTGTATTCAGACAGATACAGTGAACCAAGTGCAATATGTAAGGATGAAAGAAGAAGAGATGA
CAAAGAAATCCAAGTAAATGCCTTGTCTTTGCAAATGTTTTTATATTAAATCATAAGGAAGGAACTACTTGCCTTAAATGTTAATATCAA
AAGAGTTTTCTAACAAGGTTAATACCTTAGTTCTTAACATTTTTTTTCTTTATGTGTAGTGTTTTCATGCTACCTTGGTAGGAAACTTAT
TTACAAACCATATTAAAAGGCTAATTTAAATATAAATAATATAAAGTGCTCTGAATAAAGCAGAAATATATTACAGTTCATTCCACAGAA
AGCATCCAAACCACCCAAATGACCAAGGCATATATAGTATTTGGAGGAATCAGGGGTTTGGAAGGAGTAGGGAGGAGAATGAAGGAAAAT
GCAACCAGCATGATTATAGTGTGTTCATTTAGATAAAAGTAGAAGGCACAGGAGAGGTAGCAAAGGCCAGGCTTTTCTTTGGTTTTCTTC
AAACATAGGTGAAAAAAACACTGCCATTCACAAGTCAAGGAACCCAGGGCCAGCTGGAAGTGTGGAGCACACATGCTGTGGAGCACACAT
GCTGTGGAGATTGCAGTGTGTCTGAGGTTTGTGTAGTAGTGGAAGATTTTAGGTATGTAGAGCAAGTTGAAAATGGATTGAGACTGCATG
GTGGCATAAATGAGAAATTGCCTGTAGCATCTAGTCTACTTGAAGGAAGTGGAGACATAAGGAGAGACAAAAACAGGTTTGTGCCATAAA
GTATTTTTTCAAAGACACCAAGATGTGGTAAATGAAAATTATTAGTTCACTTCCCTGCTGCCATGAAACTTTGCCTTAAGAAGGTGCTGG
ATTCCAAGGTTTGTAAAGGCATCTCGGTAAAGACTGCTTTTTGAATGCATATGATTTTGCATCAGCTAGACTGAGTTGATTCTGACCAGA
CTTGATGGTTTTAAGTCGGAACCGATAAATTTTAAAAAGGAGAAAAAATAATTTGACCTAGTAGTATAAAACATGAGGCTTTAATGGTAC
TTTGCTATGAAAAGAAAACACTGTATTCCTTATGCAAAACACATGTATCTTTCATTATTTATAAGTGGCCTCTCTTAGCTCAGTTACTCA
ATTCATACGTAGTATTTTTTAAAATAATTTTATATCTGTGTACCACCCCATATATTTCATATTACTGTTTCACATGTACAGCTTTCTACT
TCTTTGTAAGAACACCAACCAACCAAGGTTTAAGTGATTAATAGGCTTGAGCACCGGGTGGCAGATGTTCTATGCAGTGTGGTTCAAGTT
TCTTTGACCGCACTTATATGCATTGCTAATATGGAATTTAAGATACCATACACAGTCTCTCATGGACCTATCTCTATTGTAGAATTATGA
CTTATGTCTTACTTGCCAAATTTTTCTGAATGTGACCTTTTTTTGCTGATTTGCTGGGTTTGGGATTAACTAGCATTATTTTGCCACCTT
TATATTGTATTTATAAAAAAAAAAGTACTATCAATCAATCATACTACTTTGGATTGTTGTGCTGGTGTAATGTGGATTTAACATCAATAA

>36058_36058_1_HECW2-PALLD_HECW2_chr2_197297856_ENST00000260983_PALLD_chr4_169798874_ENST00000335742_length(amino acids)=736AA_BP=7
MDWTLSYRDPLKLQQLQNQIRLEQEAGARQPPPAPRSAPPSPPFPPPPAFPELAACTPPASPEPMSALASRSAPAMQSSGSFNYARPKQF
IAAQNLGPASGHGTPASSPSSSSLPSPMSPTPRQFGRAPVPPFAQPFGAEPEAPWGSSSPSPPPPPPPVFSPTAAFPVPDVFPLPPPPPP
LPSPGQASHCSSPATRFGHSQTPAAFLSALLPSQPPPAAVNALGLPKGVTPAGFPKKASRTARIASDEEIQGTKDAVIQDLERKLRFKED
LLNNGQPRLTYEERMARRLLGADSATVFNIQEPEEETANQEYKVSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKL
KHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRISCTGRLMVQAVNQ
RGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRE
NGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHS
TDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEAN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HECW2-PALLD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	833_890	0	1812.3333333333333	ACTN
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	833_890	272.6666666666667	1002.0	ACTN
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	833_890	0	1113.6666666666667	ACTN
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	833_890	0	673.0	ACTN
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	833_890	0	778.0	ACTN
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	766_831	0	1812.3333333333333	EPS8
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	766_831	272.6666666666667	1002.0	EPS8
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	766_831	0	1113.6666666666667	EPS8
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	766_831	0	673.0	EPS8
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	766_831	0	778.0	EPS8
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	1137_1226	0	1812.3333333333333	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	1236_1326	0	1812.3333333333333	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	1137_1226	272.6666666666667	1002.0	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	1236_1326	272.6666666666667	1002.0	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	1137_1226	0	1113.6666666666667	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	1236_1326	0	1113.6666666666667	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	1137_1226	0	673.0	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	1236_1326	0	673.0	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	1137_1226	0	778.0	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	1236_1326	0	778.0	EZR
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	646_676	0	1812.3333333333333	LASP1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	646_676	272.6666666666667	1002.0	LASP1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	646_676	0	1113.6666666666667	LASP1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	646_676	0	673.0	LASP1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	646_676	0	778.0	LASP1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	676_696	0	1812.3333333333333	SORBS2%2C SPIN90 and SRC
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	676_696	272.6666666666667	1002.0	SORBS2%2C SPIN90 and SRC
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	676_696	0	1113.6666666666667	SORBS2%2C SPIN90 and SRC
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	676_696	0	673.0	SORBS2%2C SPIN90 and SRC
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	676_696	0	778.0	SORBS2%2C SPIN90 and SRC
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	796_831	0	1812.3333333333333	SORBS2%2C SPIN90%2C SRC and PFN1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	796_831	272.6666666666667	1002.0	SORBS2%2C SPIN90%2C SRC and PFN1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	796_831	0	1113.6666666666667	SORBS2%2C SPIN90%2C SRC and PFN1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	796_831	0	673.0	SORBS2%2C SPIN90%2C SRC and PFN1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	796_831	0	778.0	SORBS2%2C SPIN90%2C SRC and PFN1
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	562_566	0	1812.3333333333333	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000261509		0	21	819_823	0	1812.3333333333333	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	562_566	272.6666666666667	1002.0	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000335742		9	21	819_823	272.6666666666667	1002.0	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	562_566	0	1113.6666666666667	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000505667		0	22	819_823	0	1113.6666666666667	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	562_566	0	673.0	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000507735		0	12	819_823	0	673.0	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	562_566	0	778.0	VASP
Tgene	PALLD	chr2:197297856	chr4:169798874	ENST00000512127		0	19	819_823	0	778.0	VASP

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HECW2	chr2:197297856	chr4:169798874	ENST00000260983	-	2	29	737_1068	97.33333333333333	1573.0	TP73
Hgene	HECW2	chr2:197297856	chr4:169798874	ENST00000409111	-	1	27	737_1068	0	1217.0	TP73

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HECW2-PALLD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HECW2-PALLD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source