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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HEG1-SLC12A8 (FusionGDB2 ID:36063)

Fusion Gene Summary for HEG1-SLC12A8

check button Fusion gene summary
Fusion gene informationFusion gene name: HEG1-SLC12A8
Fusion gene ID: 36063
HgeneTgene
Gene symbol

HEG1

SLC12A8

Gene ID

57493

84561

Gene nameheart development protein with EGF like domains 1solute carrier family 12 member 8
SynonymsHEG|MST112|MSTP112CCC9
Cytomap

3q21.2

3q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein HEG homolog 1heart of glasssolute carrier family 12 member 8cation-chloride cotransporter 9solute carrier family 12 (sodium/potassium/chloride transporters), member 8
Modification date2020031320200313
UniProtAcc

Q9ULI3

.
Ensembl transtripts involved in fusion geneENST00000311127, ENST00000477536, 
ENST00000314584, ENST00000430155, 
ENST00000465475, ENST00000393469, 
ENST00000423114, ENST00000469902, 
Fusion gene scores* DoF score7 X 8 X 8=4485 X 6 X 8=240
# samples 1112
** MAII scorelog2(11/448*10)=-2.02599520853294
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/240*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HEG1 [Title/Abstract] AND SLC12A8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHEG1(124774419)-SLC12A8(124839530), # samples:2
HEG1(124696703)-SLC12A8(124811042), # samples:2
Anticipated loss of major functional domain due to fusion event.HEG1-SLC12A8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HEG1-SLC12A8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHEG1

GO:1905709

negative regulation of membrane permeability

26780829

HgeneHEG1

GO:2000299

negative regulation of Rho-dependent protein serine/threonine kinase activity

26780829


check buttonFusion gene breakpoints across HEG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC12A8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J7-01AHEG1chr3

124774419

-SLC12A8chr3

124839530

-
ChimerDB4BRCATCGA-A8-A07C-01AHEG1chr3

124696703

-SLC12A8chr3

124811042

-
ChimerDB4LUSCTCGA-77-A5GH-01AHEG1chr3

124774419

-SLC12A8chr3

124854626

-
ChimerDB4SARCTCGA-QQ-A5VA-01AHEG1chr3

124738106

-SLC12A8chr3

124802896

-
ChimerDB4STADTCGA-CG-4449-01AHEG1chr3

124774419

-SLC12A8chr3

124829179

-


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Fusion Gene ORF analysis for HEG1-SLC12A8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000311127ENST00000314584HEG1chr3

124774419

-SLC12A8chr3

124839530

-
5CDS-5UTRENST00000311127ENST00000314584HEG1chr3

124774419

-SLC12A8chr3

124854626

-
5CDS-5UTRENST00000311127ENST00000430155HEG1chr3

124774419

-SLC12A8chr3

124839530

-
5CDS-5UTRENST00000311127ENST00000465475HEG1chr3

124774419

-SLC12A8chr3

124839530

-
5CDS-5UTRENST00000311127ENST00000465475HEG1chr3

124738106

-SLC12A8chr3

124802896

-
5CDS-5UTRENST00000311127ENST00000465475HEG1chr3

124774419

-SLC12A8chr3

124829179

-
5CDS-intronENST00000311127ENST00000314584HEG1chr3

124696703

-SLC12A8chr3

124811042

-
5CDS-intronENST00000311127ENST00000430155HEG1chr3

124696703

-SLC12A8chr3

124811042

-
5CDS-intronENST00000311127ENST00000430155HEG1chr3

124774419

-SLC12A8chr3

124854626

-
5CDS-intronENST00000311127ENST00000465475HEG1chr3

124696703

-SLC12A8chr3

124811042

-
5CDS-intronENST00000311127ENST00000465475HEG1chr3

124774419

-SLC12A8chr3

124854626

-
5UTR-3CDSENST00000477536ENST00000314584HEG1chr3

124738106

-SLC12A8chr3

124802896

-
5UTR-3CDSENST00000477536ENST00000393469HEG1chr3

124738106

-SLC12A8chr3

124802896

-
5UTR-3CDSENST00000477536ENST00000423114HEG1chr3

124738106

-SLC12A8chr3

124802896

-
5UTR-3CDSENST00000477536ENST00000430155HEG1chr3

124738106

-SLC12A8chr3

124802896

-
5UTR-3CDSENST00000477536ENST00000469902HEG1chr3

124738106

-SLC12A8chr3

124802896

-
5UTR-5UTRENST00000477536ENST00000465475HEG1chr3

124738106

-SLC12A8chr3

124802896

-
Frame-shiftENST00000311127ENST00000314584HEG1chr3

124738106

-SLC12A8chr3

124802896

-
Frame-shiftENST00000311127ENST00000393469HEG1chr3

124774419

-SLC12A8chr3

124839530

-
Frame-shiftENST00000311127ENST00000393469HEG1chr3

124696703

-SLC12A8chr3

124811042

-
Frame-shiftENST00000311127ENST00000393469HEG1chr3

124774419

-SLC12A8chr3

124854626

-
Frame-shiftENST00000311127ENST00000393469HEG1chr3

124738106

-SLC12A8chr3

124802896

-
Frame-shiftENST00000311127ENST00000423114HEG1chr3

124774419

-SLC12A8chr3

124839530

-
Frame-shiftENST00000311127ENST00000423114HEG1chr3

124696703

-SLC12A8chr3

124811042

-
Frame-shiftENST00000311127ENST00000423114HEG1chr3

124774419

-SLC12A8chr3

124854626

-
Frame-shiftENST00000311127ENST00000423114HEG1chr3

124738106

-SLC12A8chr3

124802896

-
Frame-shiftENST00000311127ENST00000469902HEG1chr3

124774419

-SLC12A8chr3

124839530

-
Frame-shiftENST00000311127ENST00000469902HEG1chr3

124696703

-SLC12A8chr3

124811042

-
Frame-shiftENST00000311127ENST00000469902HEG1chr3

124774419

-SLC12A8chr3

124854626

-
In-frameENST00000311127ENST00000314584HEG1chr3

124774419

-SLC12A8chr3

124829179

-
In-frameENST00000311127ENST00000393469HEG1chr3

124774419

-SLC12A8chr3

124829179

-
In-frameENST00000311127ENST00000423114HEG1chr3

124774419

-SLC12A8chr3

124829179

-
In-frameENST00000311127ENST00000430155HEG1chr3

124738106

-SLC12A8chr3

124802896

-
In-frameENST00000311127ENST00000430155HEG1chr3

124774419

-SLC12A8chr3

124829179

-
In-frameENST00000311127ENST00000469902HEG1chr3

124738106

-SLC12A8chr3

124802896

-
In-frameENST00000311127ENST00000469902HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-3CDSENST00000477536ENST00000314584HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-3CDSENST00000477536ENST00000393469HEG1chr3

124774419

-SLC12A8chr3

124839530

-
intron-3CDSENST00000477536ENST00000393469HEG1chr3

124696703

-SLC12A8chr3

124811042

-
intron-3CDSENST00000477536ENST00000393469HEG1chr3

124774419

-SLC12A8chr3

124854626

-
intron-3CDSENST00000477536ENST00000393469HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-3CDSENST00000477536ENST00000423114HEG1chr3

124774419

-SLC12A8chr3

124839530

-
intron-3CDSENST00000477536ENST00000423114HEG1chr3

124696703

-SLC12A8chr3

124811042

-
intron-3CDSENST00000477536ENST00000423114HEG1chr3

124774419

-SLC12A8chr3

124854626

-
intron-3CDSENST00000477536ENST00000423114HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-3CDSENST00000477536ENST00000430155HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-3CDSENST00000477536ENST00000469902HEG1chr3

124774419

-SLC12A8chr3

124839530

-
intron-3CDSENST00000477536ENST00000469902HEG1chr3

124696703

-SLC12A8chr3

124811042

-
intron-3CDSENST00000477536ENST00000469902HEG1chr3

124774419

-SLC12A8chr3

124854626

-
intron-3CDSENST00000477536ENST00000469902HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-5UTRENST00000477536ENST00000314584HEG1chr3

124774419

-SLC12A8chr3

124839530

-
intron-5UTRENST00000477536ENST00000314584HEG1chr3

124774419

-SLC12A8chr3

124854626

-
intron-5UTRENST00000477536ENST00000430155HEG1chr3

124774419

-SLC12A8chr3

124839530

-
intron-5UTRENST00000477536ENST00000465475HEG1chr3

124774419

-SLC12A8chr3

124839530

-
intron-5UTRENST00000477536ENST00000465475HEG1chr3

124774419

-SLC12A8chr3

124829179

-
intron-intronENST00000477536ENST00000314584HEG1chr3

124696703

-SLC12A8chr3

124811042

-
intron-intronENST00000477536ENST00000430155HEG1chr3

124696703

-SLC12A8chr3

124811042

-
intron-intronENST00000477536ENST00000430155HEG1chr3

124774419

-SLC12A8chr3

124854626

-
intron-intronENST00000477536ENST00000465475HEG1chr3

124696703

-SLC12A8chr3

124811042

-
intron-intronENST00000477536ENST00000465475HEG1chr3

124774419

-SLC12A8chr3

124854626

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HEG1-SLC12A8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HEG1-SLC12A8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:124774419/chr3:124839530)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HEG1

Q9ULI3

.
FUNCTION: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568593_616461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568622_643461516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613309_331304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613360_377304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613383_403304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613593_616304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613622_643304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714360_377333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714383_403333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714593_616333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714622_643333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518123_142105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518154_173105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518185_205105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518233_254105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518266_289105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518309_331105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518360_377105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518383_403105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518593_616105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000043015518622_643105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714309_331304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714360_377304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714383_403304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714593_616304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714622_643304715.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHEG1chr3:124738106chr3:124802896ENST00000311127-517463_7435291382.0Compositional biasNote=Ser-rich
HgeneHEG1chr3:124774419chr3:124829179ENST00000311127-117463_7431051382.0Compositional biasNote=Ser-rich
HgeneHEG1chr3:124738106chr3:124802896ENST00000311127-5171025_10635291382.0DomainEGF-like 2%3B calcium-binding
HgeneHEG1chr3:124738106chr3:124802896ENST00000311127-517985_10235291382.0DomainEGF-like 1
HgeneHEG1chr3:124774419chr3:124829179ENST00000311127-1171025_10631051382.0DomainEGF-like 2%3B calcium-binding
HgeneHEG1chr3:124774419chr3:124829179ENST00000311127-117985_10231051382.0DomainEGF-like 1
HgeneHEG1chr3:124738106chr3:124802896ENST00000311127-5171270_13815291382.0Topological domainCytoplasmic
HgeneHEG1chr3:124738106chr3:124802896ENST00000311127-51730_12485291382.0Topological domainExtracellular
HgeneHEG1chr3:124774419chr3:124829179ENST00000311127-1171270_13811051382.0Topological domainCytoplasmic
HgeneHEG1chr3:124774419chr3:124829179ENST00000311127-11730_12481051382.0Topological domainExtracellular
HgeneHEG1chr3:124738106chr3:124802896ENST00000311127-5171249_12695291382.0TransmembraneHelical
HgeneHEG1chr3:124774419chr3:124829179ENST00000311127-1171249_12691051382.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113123_142660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113154_173660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113185_205660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113233_254660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113266_289660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113309_331660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113360_377660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000393469111337_60660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113383_403660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113593_616660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000003934691113622_643660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000393469111372_93660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000393469111399_116660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214123_142689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214154_173689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214185_205689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214233_254689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214266_289689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214309_331689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214360_377689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000423114121437_60689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214383_403689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214593_616689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004231141214622_643689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000423114121472_93689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000423114121499_116689744.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568123_142461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568154_173461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568185_205461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568233_254461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568266_289461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568309_331461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568360_377461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004301556837_60461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST0000043015568383_403461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004301556872_93461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004301556899_116461516.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214123_142660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214154_173660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214185_205660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214233_254660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214266_289660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214309_331660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214360_377660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000469902121437_60660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214383_403660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214593_616660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST000004699021214622_643660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000469902121472_93660715.0TransmembraneHelical
TgeneSLC12A8chr3:124738106chr3:124802896ENST00000469902121499_116660715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613123_142304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613154_173304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613185_205304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613233_254304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000393469613266_289304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000039346961337_60304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000039346961372_93304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000039346961399_116304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714123_142333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714154_173333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714185_205333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714233_254333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714266_289333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000423114714309_331333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000042311471437_60333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000042311471472_93333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000042311471499_116333744.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST000004301551837_60105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST000004301551872_93105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST000004301551899_116105516.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714123_142304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714154_173304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714185_205304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714233_254304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST00000469902714266_289304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000046990271437_60304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000046990271472_93304715.0TransmembraneHelical
TgeneSLC12A8chr3:124774419chr3:124829179ENST0000046990271499_116304715.0TransmembraneHelical


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Fusion Gene Sequence for HEG1-SLC12A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HEG1-SLC12A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HEG1-SLC12A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HEG1-SLC12A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource