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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HELZ-PSMD12 (FusionGDB2 ID:36104)

Fusion Gene Summary for HELZ-PSMD12

check button Fusion gene summary
Fusion gene informationFusion gene name: HELZ-PSMD12
Fusion gene ID: 36104
HgeneTgene
Gene symbol

HELZ

PSMD12

Gene ID

9931

5718

Gene namehelicase with zinc fingerproteasome 26S subunit, non-ATPase 12
SynonymsDHRC|DRHC|HUMORF5Rpn5|STISS|p55
Cytomap

17q24.2

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionprobable helicase with zinc finger domaindown-regulated in human cancers proteinhelicase with zinc finger domain26S proteasome non-ATPase regulatory subunit 1226S proteasome regulatory subunit RPN526S proteasome regulatory subunit p55proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Modification date2020031320200313
UniProtAcc

P42694

.
Ensembl transtripts involved in fusion geneENST00000358691, ENST00000580168, 
ENST00000580662, 		ENST00000581618, 
ENST00000357146, ENST00000356126, 
Fusion gene scores* DoF score22 X 22 X 9=43566 X 5 X 3=90
# samples 247
** MAII scorelog2(24/4356*10)=-4.18189764310839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HELZ [Title/Abstract] AND PSMD12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHELZ(65147162)-PSMD12(65337168), # samples:2
Anticipated loss of major functional domain due to fusion event.HELZ-PSMD12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HELZ-PSMD12 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HELZ-PSMD12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HELZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMD12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A6JE-01AHELZchr17

65147162

-PSMD12chr17

65337168

-
ChimerDB4HNSCTCGA-CV-A6JEHELZchr17

65147162

-PSMD12chr17

65337168

-


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Fusion Gene ORF analysis for HELZ-PSMD12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358691ENST00000581618HELZchr17

65147162

-PSMD12chr17

65337168

-
5CDS-intronENST00000580168ENST00000581618HELZchr17

65147162

-PSMD12chr17

65337168

-
Frame-shiftENST00000358691ENST00000357146HELZchr17

65147162

-PSMD12chr17

65337168

-
Frame-shiftENST00000580168ENST00000357146HELZchr17

65147162

-PSMD12chr17

65337168

-
In-frameENST00000358691ENST00000356126HELZchr17

65147162

-PSMD12chr17

65337168

-
In-frameENST00000580168ENST00000356126HELZchr17

65147162

-PSMD12chr17

65337168

-
intron-3CDSENST00000580662ENST00000356126HELZchr17

65147162

-PSMD12chr17

65337168

-
intron-3CDSENST00000580662ENST00000357146HELZchr17

65147162

-PSMD12chr17

65337168

-
intron-intronENST00000580662ENST00000581618HELZchr17

65147162

-PSMD12chr17

65337168

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358691HELZchr1765147162-ENST00000356126PSMD12chr1765337168-566025231672557796
ENST00000580168HELZchr1765147162-ENST00000356126PSMD12chr1765337168-566325261672560797

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358691ENST00000356126HELZchr1765147162-PSMD12chr1765337168-0.000254840.9997452
ENST00000580168ENST00000356126HELZchr1765147162-PSMD12chr1765337168-0.0002638870.99973613

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Fusion Genomic Features for HELZ-PSMD12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HELZ-PSMD12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:65147162/chr17:65337168)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HELZ

P42694

.
FUNCTION: May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHELZchr17:65147162chr17:65337168ENST00000358691-1833668_6757851943.0Nucleotide bindingATP
HgeneHELZchr17:65147162chr17:65337168ENST00000358691-1833178_2067851943.0Zinc fingerC3H1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHELZchr17:65147162chr17:65337168ENST00000358691-1833794_7977851943.0MotifNote=DEAA box
TgenePSMD12chr17:65147162chr17:65337168ENST00000356126911242_420387457.0DomainPCI
TgenePSMD12chr17:65147162chr17:65337168ENST00000357146810242_420367437.0DomainPCI


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Fusion Gene Sequence for HELZ-PSMD12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36104_36104_1_HELZ-PSMD12_HELZ_chr17_65147162_ENST00000358691_PSMD12_chr17_65337168_ENST00000356126_length(transcript)=5660nt_BP=2523nt
CAAGTGGATCCAAGATGGCGTAGAAAGTAATGACAGGATTTGGATGAAGTAATGGATCACTAATGAACTACAGTGCTGGTGAGATGTGTA
AGAAATTATAAAGAGCTCTGATGGGCTATTTGGGTGATACCCAGTGCAGTGAACTGCAGGATTTTTGTCCCTGAGTCATGGAAGACAGAA
GAGCTGAAAAGTCATGTGAACAAGCATGTGAATCACTTAAGAGGCAGGACTATGAAATGGCCCTCAAGCACTGCACAGAGGCCCTTCTTT
CTCTTGGCCAGTACTCCATGGCAGACTTCACAGGGCCTTGTCCATTGGAAATAGAACGCATCAAAATCGAGAGTCTTCTCTACAGAATTG
CCTCATTTTTGCAACTGAAAAATTATGTGCAAGCTGATGAAGATTGTAGACATGTGCTGGGAGAAGGACTGGCCAAGGGAGAAGATGCCT
TTCGGGCAGTGCTTTGCTGCATGCAGCTGAAAGGGAAGCTCCAACCTGTATCCACCATTCTTGCCAAGTCACTCACAGGAGAGTCCCTGA
ATGGGATGGTAACAAAGGATTTGACAAGACTAAAAACACTTCTCTCAGAAACAGAGACAGCAACTAGTAACGCCCTCTCTGGATATCACG
TGGAAGACTTAGATGAGGGGTCTTGTAATGGTTGGCATTTCCGCCCACCACCTAGGGGAATCACAAGCAGCGAGGAATATACTTTGTGTA
AAAGATTTTTAGAACAAGGAATCTGTAGGTATGGTGCCCAGTGTACTTCAGCACATTCCCAGGAAGAACTAGCAGAATGGCAGAAAAGAT
ATGCTTCACGGCTGATAAAATTGAAACAGCAAAATGAGAATAAACAGCTCTCAGGCAGTTACATGGAAACCTTGATAGAAAAGTGGATGA
ATTCATTGTCTCCTGAGAAAGTGCTTAGTGAATGTATAGAAGGAGTAAAGGTAGAGCACAATCCTGACCTGTCAGTTACTGTCAGCACCA
AAAAATCCCACCAGACATGGACCTTTGCTCTCACTTGTAAGCCTGCAAGAATGCTGTATCGTGTAGCATTGCTTTATGATGCTCATCGTC
CTCATTTTAGTATCATTGCAATATCTGCCGGAGATAGTACTACCCAGGTATCACAAGAAGTCCCAGAAAACTGTCAAGAATGGATAGGAG
GAAAGATGGCCCAAAATGGATTAGATCATTACGTGTATAAAGTCGGGATAGCATTTAACACAGAAATATTTGGAACTTTTCGCCAAACCA
TAGTTTTCGACTTTGGATTGGAACCAGTACTCATGCAAAGAGTAATGATTGATGCAGCTTCTACAGAAGATCTCGAATACCTGATGCATG
CAAAACAGCAGCTAGTAACCACAGCTAAACGTTGGGATTCTTCCTCTAAGACTATTATAGATTTTGAACCTAATGAAACTACTGATTTGG
AGAAGAGCCTTCTTATCAGATACCAAATTCCCCTCTCTGCTGACCAGCTATTTACTCAGTCCGTTTTAGACAAATCATTGACCAAGAGCA
ACTATCAGTCACGGTTACATGACCTTCTTTATATTGAGGAGATAGCCCAGTATAAAGAAATCAGCAAGTTCAACCTTAAAGTGCAATTGC
AGATTCTGGCAAGCTTCATGCTCACTGGTGTTTCTGGAGGTGCAAAGTATGCTCAGAATGGACAACTTTTTGGTCGCTTTAAGCTTACTG
AAACACTTTCTGAAGATACTTTGGCTGGACGACTGGTGATGACCAAAGTCAATGCTGTTTATTTATTACCAGTCCCTAAACAGAAGTTAG
TACAGACCCAGGGAACCAAAGAGAAGGTTTATGAAGCTACTATTGAAGAAAAAACAAAGGAATATATATTTTTAAGGCTATCTAGGGAAT
GCTGTGAAGAACTTAATCTTCGGCCTGACTGTGACACACAGGTTGAACTTCAGTTTCAATTAAATCGATTACCCCTCTGTGAAATGCACT
ATGCACTAGACAGGATCAAGGACAATGGGGTTTTGTTTCCAGACATCAGTATGACTCCCACCATACCATGGAGTCCTAACAGACAATGGG
ATGAACAGTTGGATCCTCGACTAAATGCAAAACAGAAAGAGGCTGTTCTGGCCATTACCACTCCACTTGCAATCCAGCTGCCGCCTGTGC
TTATCATCGGACCCTATGGGACAGGCAAAACGTTCACTCTAGCTCAGGCTGTCAAACATATTCTGCAGCAACAGGAGACTAGGATTCTCA
TTTGCACCCATTCTAATAGTGCTGCTGATCTCTACATAAAGGATTATTTACATCCATATGTAGAAGCAGGCAATCCCCAGGCAAGACCTC
TCAGGGTATATTTCAGAAATCGCTGGGTAAAGACTGTCCACCCAGTTGTGCATCAGTACTGTTTGATCTCAAGCGCACATTCCACCTTTC
AGATGCCCCAGAAAGAAGATATTCTTAAACATCGAGTGGTGGTTGTTACCTTGAATACTTCCCAGTACCTCTGTCAGTTGGACCTTGAAC
CTGGAGTCCGAAGCCTTTCTCTCAAATCTAGTAGTTAACAAGACCATCTTTGCTAAAGTAGACAGATTAGCAGGAATTATCAACTTCCAG
AGACCCAAGGATCCAAATAATTTATTAAATGACTGGTCTCAGAAACTGAACTCATTAATGTCTCTGGTTAACAAAACTACGCATCTCATA
GCCAAAGAGGAGATGATACATAATCTACAATAAGGGTCTTAGTGCTTTAGAAAAAAGTTAAAATTGGAAGTCATTAAAAAAAGACTGTTA
TAATGGTGTATATGTTGGGGTTTTTTTTCTAAGCTTCTTTGTCTTAAATTTTAAAATAGTGAATATGTTTGAGACTCCCTTTGACCTTTC
AGTTCCCCAAGTTCATTGTTAACTTTGCATTTGCAATTGGTGCAAAAATACAGATTTCTGTCGTCTGAATACACAAAAAGTTGTGTCATA
ACTTACCCAGATATGTTTTTCTATCATTTGAAACCTTTTTAGCTACTGTTTGTTTTCATTCAACTAACAAACATATTCCAATAATAAAAG
CAGTATATACATATTTCCTTTCTACAGTTACCTCTGATTCTCAACATTTTGTGGGGTAGTGATTTGGCAAGTGTTTTTTAAATAAAACAA
ATCTCATTGTAAAGCTATCAGTCATTTAGTAGAATAGAAAAGCAACATAGAGCATACAAGAACATTTGGGATAGAGTTGTGATTTGTGAA
GAATTTGTACTTTGATATTGTGGCGGAAAGTCTAGACTGAGTGTGTATGCTGGTAAACTGTAGACTTTTTTTTTTTTTTTTTTGAGTCCG
GCTGGTTCCAATCACAGTAGCTTGATTGCTTTCAGCCCTCATCCTCTCACTTGATCAGTTGTTCAACAGAATCAGCTGACATAATTGACA
CAGTTTATTGGGTGTTAAGTCCGCTCTATAGGGATAGTGACTACTTTTTTTTTTTTTTTTTTTTTGCTCTTCTTCCTCTCCCCTTTCTTT
ATATGGGTTTAAATTTAACATAAAGTTGTTTTTATAAGGCTTATTTGTGGCTTTAACTTGTAAGTCTGATTACATCATTATTGTTCCAAA
TTCATTATCTCTGTAGGAACTTTTAGTTCCATTATATGAACACTGGATAACCTAATTTTTTTTAATGCTTTAAAAAAATGGCAAAAAGAC
GTCAGGCCACCCTCATAGTAAGTGGTGTAGTATTAAAATATTTTCACGGAATTAAAAGTAGCTTGCTGTCAAAGAAACACCTGAGATGAA
TTGGTGTGAACGAATTTTGCAAGTTTAATTTGATTTATTTCAGAGAAAATAGAAAAAACAATGTTAGAAGGTTATTTAAAATGATACTTA
AATAAAGAAAGTGTGAGGTCTACTTTAAAAAAATTCAAATGAAGAGAAAAAGAAAAACAGCATTCTAGAAATGGCATTTCTCCTAATTAA
TTTTCCACTTAATGGAAGATTATCAATTGTCCTATTTTATGATCCCAGGACTGAAGACAGTTGTGGGATATCTGTCATATTTATCCTGTG
AGTCATTGTGAATAATGACATACAGTACTGAAGTAATCTGATTTTATTCTTTGGAAATTCAATGCATTGGTCACACTAATAACATCAACA
TCTGCTATCACTTATCTTTTTAAAACTAACCAAAAAAGGCCGGGTGCAGTGGATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCATC
TAAGGTCAGGATTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAAAAATACAAAAATTTGCCGGGCGTGGTGGCG
TGTGCCTGTAGTCCCAGTTACTTGGGAGGCTGAGGTGGGAGAATTCCTTGAAGCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCACACC
ATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAACAAAACTGGAAAGTTCAGAAACAGAAGTTCACACTAA
CAGAGTATGGTTTTAATTTTCCTTTGAATGAAAAGGATAGAAGATAAAATTGTGTATTGTTAACATGTAAATAAAATTGGAGCTAATTTG
AAACTAGCTTCTCAATAACTTCATCTTTCTAGAGACTCATTACCTGTGGGCTTGTCAAACCTGGACTATTTGGCCAAATAGGTTGCTATA
GAGATTGCAAGTGTTCCTCCTCTTTATTTTTTTCATATTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGATTGCAGTGTCACG
ATCTCGGCTCACTGCAACCTTTGCCTCCCATATTCAAGCAGTTCTCCTGCCTCAACCTCCCAAGTAGCTGGGATTATAGGCGCCTGCCAC
CACACCTAGCTAATTTTTGTGTTTTTAGTAGAGATGGTTTCATCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACC
CGCCTTGGCTGCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCAACTCCTCTTTCGTCTTTCTTTAACACACACTAGGCTCTT
TGTGTATTATGATTCAGTGCTATTTGTAACTGTGTCCCAGTGACCAAATTGCACTCGACTCGATCAGCTGTTCATCCATTTCGTGTTTTT
TCCTGTCAAACATTAATCCAGCAAATATATGAGGTATTTACCAATTTATTTTCTTAGTATTACAAAATAATTCATTAGCATAAAGTACAA
TAGTGAAATATTTGAGTTGTTCGGAACCTCAATTAATCCTGTTTTACATTTCAGACCTAAAGCTGGCAATCAGGAGAAGAAGCACTTTGT
TTTAAATGTGGAGAAGATAACACTTGATTCCATTTCATTGTCATTAGTGTATTAACCAGCAGGAGAGGTGATGAGCCATTTTTCAAATGA
AATACCTTTTATTTCCATATAATTTTTTTATTTTAGAGTTCAATAGCTGTTTCTATGATTATCCTCAATTTCCATATGTTACTGAATCTG
AAAAACATCTTTAAAATTCAAACAGTTCCATTTTCTCTCTTGTAAGTGTTAAATGTGATAAAAGTACATATTTTAAATTGTTTTCAGCTC

>36104_36104_1_HELZ-PSMD12_HELZ_chr17_65147162_ENST00000358691_PSMD12_chr17_65337168_ENST00000356126_length(amino acids)=796AA_BP=
MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESLLYRIASFLQLKNYVQADEDCRHVLGEGLAK
GEDAFRAVLCCMQLKGKLQPVSTILAKSLTGESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSV
TVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKS
LTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSP
NRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNP

--------------------------------------------------------------
>36104_36104_2_HELZ-PSMD12_HELZ_chr17_65147162_ENST00000580168_PSMD12_chr17_65337168_ENST00000356126_length(transcript)=5663nt_BP=2526nt
CAAGTGGATCCAAGATGGCGTAGAAAGTAATGACAGGATTTGGATGAAGTAATGGATCACTAATGAACTACAGTGCTGGTGAGATGTGTA
AGAAATTATAAAGAGCTCTGATGGGCTATTTGGGTGATACCCAGTGCAGTGAACTGCAGGATTTTTGTCCCTGAGTCATGGAAGACAGAA
GAGCTGAAAAGTCATGTGAACAAGCATGTGAATCACTTAAGAGGCAGGACTATGAAATGGCCCTCAAGCACTGCACAGAGGCCCTTCTTT
CTCTTGGCCAGTACTCCATGGCAGACTTCACAGGGCCTTGTCCATTGGAAATAGAACGCATCAAAATCGAGAGTCTTCTCTACAGAATTG
CCTCATTTTTGCAACTGAAAAATTATGTGCAAGCTGATGAAGATTGTAGACATGTGCTGGGAGAAGGACTGGCCAAGGGAGAAGATGCCT
TTCGGGCAGTGCTTTGCTGCATGCAGCTGAAAGGGAAGCTCCAACCTGTATCCACCATTCTTGCCAAGTCACTCACAGGAGAGTCCCTGA
ATGGGATGGTAACAAAGGATTTGACAAGACTAAAAACACTTCTCTCAGAAACAGAGACAGCAACTAGTAACGCCCTCTCTGGATATCACG
TGGAAGACTTAGATGAGGGGTCTTGTAATGGTTGGCATTTCCGCCCACCACCTAGGGGAATCACAAGCAGCGAGGAATATACTTTGTGTA
AAAGATTTTTAGAACAAGGAATCTGTAGGTATGGTGCCCAGTGTACTTCAGCACATTCCCAGGAAGAACTAGCAGAATGGCAGAAAAGAT
ATGCTTCACGGCTGATAAAATTGAAACAGCAAAATGAGAATAAACAGCTCTCAGGCAGTTACATGGAAACCTTGATAGAAAAGTGGATGA
ATTCATTGTCTCCTGAGAAAGTGCTTAGTGAATGTATAGAAGGAGTAAAGGTAGAGCACAATCCTGACCTGTCAGTTACTGTCAGCACCA
AAAAATCCCACCAGACATGGACCTTTGCTCTCACTTGTAAGCCTGCAAGAATGCTGTATCGTGTAGCATTGCTTTATGATGCTCATCGTC
CTCATTTTAGTATCATTGCAATATCTGCCGGAGATAGTACTACCCAGGTATCACAAGAAGTCCCAGAAAACTGTCAAGAATGGATAGGAG
GAAAGATGGCCCAAAATGGATTAGATCATTACGTGTATAAAGTCGGGATAGCATTTAACACAGAAATATTTGGAACTTTTCGCCAAACCA
TAGTTTTCGACTTTGGATTGGAACCAGTACTCATGCAAAGAGTAATGATTGATGCAGCTTCTACAGAAGATCTCGAATACCTGATGCATG
CAAAACAGCAGCTAGTAACCACAGCTAAACGTTGGGATTCTTCCTCTAAGACTATTATAGATTTTGAACCTAATGAAACTACTGATTTGG
AGAAGAGCCTTCTTATCAGATACCAAATTCCCCTCTCTGCTGACCAGCTATTTACTCAGTCCGTTTTAGACAAATCATTGACCAAGAGCA
ACTATCAGTCACGGTTACATGACCTTCTTTATATTGAGGAGATAGCCCAGTATAAAGAAATCAGCAAGTTCAACCTTAAAGTGCAATTGC
AGATTCTGGCAAGCTTCATGCTCACTGGTGTTTCTGGAGGTGCAAAGTATGCTCAGAATGGACAACTTTTTGGTCGCTTTAAGCTTACTG
AAACACTTTCTGAAGATACTTTGGCTGGACGACTGGTGATGACCAAAGTCAATGCTGTTTATTTATTACCAGTCCCTAAACAGAAGTTAG
TACAGACCCAGGGAACCAAAGAGAAGGTTTATGAAGCTACTATTGAAGAAAAAACAAAGGAATATATATTTTTAAGGCTATCTAGGGAAT
GCTGTGAAGAACTTAATCTTCGGCCTGACTGTGACACACAGGTTGAACTTCAGTTTCAATTAAATCGATTACCCCTCTGTGAAATGCACT
ATGCACTAGACAGGATCAAGGACAATGGGGTTTTGTTTCCAGACATCAGTATGACTCCCACCATACCATGGAGTCCTAACAGACAATGGG
ATGAACAGTTGGATCCTCGACTAAATGCAAAACAGAAAGAGGCTGTTCTGGCCATTACCACTCCACTTGCAATCCAGCTGCCGCCTGTGC
TTATCATCGGACCCTATGGGACAGGCAAAACGTTCACTCTAGCTCAGGCTGTCAAACATATTCTGCAGCAACAGGAGACTAGCAGGATTC
TCATTTGCACCCATTCTAATAGTGCTGCTGATCTCTACATAAAGGATTATTTACATCCATATGTAGAAGCAGGCAATCCCCAGGCAAGAC
CTCTCAGGGTATATTTCAGAAATCGCTGGGTAAAGACTGTCCACCCAGTTGTGCATCAGTACTGTTTGATCTCAAGCGCACATTCCACCT
TTCAGATGCCCCAGAAAGAAGATATTCTTAAACATCGAGTGGTGGTTGTTACCTTGAATACTTCCCAGTACCTCTGTCAGTTGGACCTTG
AACCTGGAGTCCGAAGCCTTTCTCTCAAATCTAGTAGTTAACAAGACCATCTTTGCTAAAGTAGACAGATTAGCAGGAATTATCAACTTC
CAGAGACCCAAGGATCCAAATAATTTATTAAATGACTGGTCTCAGAAACTGAACTCATTAATGTCTCTGGTTAACAAAACTACGCATCTC
ATAGCCAAAGAGGAGATGATACATAATCTACAATAAGGGTCTTAGTGCTTTAGAAAAAAGTTAAAATTGGAAGTCATTAAAAAAAGACTG
TTATAATGGTGTATATGTTGGGGTTTTTTTTCTAAGCTTCTTTGTCTTAAATTTTAAAATAGTGAATATGTTTGAGACTCCCTTTGACCT
TTCAGTTCCCCAAGTTCATTGTTAACTTTGCATTTGCAATTGGTGCAAAAATACAGATTTCTGTCGTCTGAATACACAAAAAGTTGTGTC
ATAACTTACCCAGATATGTTTTTCTATCATTTGAAACCTTTTTAGCTACTGTTTGTTTTCATTCAACTAACAAACATATTCCAATAATAA
AAGCAGTATATACATATTTCCTTTCTACAGTTACCTCTGATTCTCAACATTTTGTGGGGTAGTGATTTGGCAAGTGTTTTTTAAATAAAA
CAAATCTCATTGTAAAGCTATCAGTCATTTAGTAGAATAGAAAAGCAACATAGAGCATACAAGAACATTTGGGATAGAGTTGTGATTTGT
GAAGAATTTGTACTTTGATATTGTGGCGGAAAGTCTAGACTGAGTGTGTATGCTGGTAAACTGTAGACTTTTTTTTTTTTTTTTTTGAGT
CCGGCTGGTTCCAATCACAGTAGCTTGATTGCTTTCAGCCCTCATCCTCTCACTTGATCAGTTGTTCAACAGAATCAGCTGACATAATTG
ACACAGTTTATTGGGTGTTAAGTCCGCTCTATAGGGATAGTGACTACTTTTTTTTTTTTTTTTTTTTTGCTCTTCTTCCTCTCCCCTTTC
TTTATATGGGTTTAAATTTAACATAAAGTTGTTTTTATAAGGCTTATTTGTGGCTTTAACTTGTAAGTCTGATTACATCATTATTGTTCC
AAATTCATTATCTCTGTAGGAACTTTTAGTTCCATTATATGAACACTGGATAACCTAATTTTTTTTAATGCTTTAAAAAAATGGCAAAAA
GACGTCAGGCCACCCTCATAGTAAGTGGTGTAGTATTAAAATATTTTCACGGAATTAAAAGTAGCTTGCTGTCAAAGAAACACCTGAGAT
GAATTGGTGTGAACGAATTTTGCAAGTTTAATTTGATTTATTTCAGAGAAAATAGAAAAAACAATGTTAGAAGGTTATTTAAAATGATAC
TTAAATAAAGAAAGTGTGAGGTCTACTTTAAAAAAATTCAAATGAAGAGAAAAAGAAAAACAGCATTCTAGAAATGGCATTTCTCCTAAT
TAATTTTCCACTTAATGGAAGATTATCAATTGTCCTATTTTATGATCCCAGGACTGAAGACAGTTGTGGGATATCTGTCATATTTATCCT
GTGAGTCATTGTGAATAATGACATACAGTACTGAAGTAATCTGATTTTATTCTTTGGAAATTCAATGCATTGGTCACACTAATAACATCA
ACATCTGCTATCACTTATCTTTTTAAAACTAACCAAAAAAGGCCGGGTGCAGTGGATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATC
ATCTAAGGTCAGGATTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAAAAATACAAAAATTTGCCGGGCGTGGTG
GCGTGTGCCTGTAGTCCCAGTTACTTGGGAGGCTGAGGTGGGAGAATTCCTTGAAGCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATCAC
ACCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAACAAAACTGGAAAGTTCAGAAACAGAAGTTCACAC
TAACAGAGTATGGTTTTAATTTTCCTTTGAATGAAAAGGATAGAAGATAAAATTGTGTATTGTTAACATGTAAATAAAATTGGAGCTAAT
TTGAAACTAGCTTCTCAATAACTTCATCTTTCTAGAGACTCATTACCTGTGGGCTTGTCAAACCTGGACTATTTGGCCAAATAGGTTGCT
ATAGAGATTGCAAGTGTTCCTCCTCTTTATTTTTTTCATATTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGATTGCAGTGTC
ACGATCTCGGCTCACTGCAACCTTTGCCTCCCATATTCAAGCAGTTCTCCTGCCTCAACCTCCCAAGTAGCTGGGATTATAGGCGCCTGC
CACCACACCTAGCTAATTTTTGTGTTTTTAGTAGAGATGGTTTCATCATGTTGGCCGGGCTGGTCTCAAACTCCTGACCTCAGGTGATCC
ACCCGCCTTGGCTGCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCCAACTCCTCTTTCGTCTTTCTTTAACACACACTAGGCT
CTTTGTGTATTATGATTCAGTGCTATTTGTAACTGTGTCCCAGTGACCAAATTGCACTCGACTCGATCAGCTGTTCATCCATTTCGTGTT
TTTTCCTGTCAAACATTAATCCAGCAAATATATGAGGTATTTACCAATTTATTTTCTTAGTATTACAAAATAATTCATTAGCATAAAGTA
CAATAGTGAAATATTTGAGTTGTTCGGAACCTCAATTAATCCTGTTTTACATTTCAGACCTAAAGCTGGCAATCAGGAGAAGAAGCACTT
TGTTTTAAATGTGGAGAAGATAACACTTGATTCCATTTCATTGTCATTAGTGTATTAACCAGCAGGAGAGGTGATGAGCCATTTTTCAAA
TGAAATACCTTTTATTTCCATATAATTTTTTTATTTTAGAGTTCAATAGCTGTTTCTATGATTATCCTCAATTTCCATATGTTACTGAAT
CTGAAAAACATCTTTAAAATTCAAACAGTTCCATTTTCTCTCTTGTAAGTGTTAAATGTGATAAAAGTACATATTTTAAATTGTTTTCAG

>36104_36104_2_HELZ-PSMD12_HELZ_chr17_65147162_ENST00000580168_PSMD12_chr17_65337168_ENST00000356126_length(amino acids)=797AA_BP=
MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESLLYRIASFLQLKNYVQADEDCRHVLGEGLAK
GEDAFRAVLCCMQLKGKLQPVSTILAKSLTGESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHNPDLSV
TVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKS
LTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSP
NRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGN

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Fusion Gene PPI Analysis for HELZ-PSMD12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HELZ-PSMD12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HELZ-PSMD12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource