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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HERC2-TMEM145 (FusionGDB2 ID:36168)

Fusion Gene Summary for HERC2-TMEM145

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC2-TMEM145
Fusion gene ID: 36168
HgeneTgene
Gene symbol

HERC2

TMEM145

Gene ID

8924

284339

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 2transmembrane protein 145
SynonymsD15F37S1|MRT38|SHEP1|jdf2|p528-
Cytomap

15q13.1

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HERC2HECT-type E3 ubiquitin transferase HERC2hect domain and RCC1-like domain-containing protein 2hect domain and RLD 2probable E3 ubiquitin-protein ligase HERC2transmembrane protein 145
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261609, ENST00000563945, 
ENST00000301204, ENST00000598766, 
ENST00000601020, 
Fusion gene scores* DoF score14 X 12 X 9=15121 X 2 X 1=2
# samples 152
** MAII scorelog2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: HERC2 [Title/Abstract] AND TMEM145 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHERC2(28544548)-TMEM145(42818424), # samples:2
HERC2(28544547)-TMEM145(42818423), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHERC2

GO:0006974

cellular response to DNA damage stimulus

22508508

HgeneHERC2

GO:0016567

protein ubiquitination

20304803


check buttonFusion gene breakpoints across HERC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM145 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A8WS-01AHERC2chr15

28544548

-TMEM145chr19

42818424

+
ChimerDB4PRADTCGA-V1-A8WSHERC2chr15

28544547

-TMEM145chr19

42818423

+
ChimerDB4PRADTCGA-V1-A8WSHERC2chr15

28544548

-TMEM145chr19

42818424

+


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Fusion Gene ORF analysis for HERC2-TMEM145

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261609ENST00000301204HERC2chr15

28544548

-TMEM145chr19

42818424

+
In-frameENST00000261609ENST00000301204HERC2chr15

28544547

-TMEM145chr19

42818423

+
In-frameENST00000261609ENST00000598766HERC2chr15

28544548

-TMEM145chr19

42818424

+
In-frameENST00000261609ENST00000598766HERC2chr15

28544547

-TMEM145chr19

42818423

+
In-frameENST00000261609ENST00000601020HERC2chr15

28544548

-TMEM145chr19

42818424

+
In-frameENST00000261609ENST00000601020HERC2chr15

28544547

-TMEM145chr19

42818423

+
intron-3CDSENST00000563945ENST00000301204HERC2chr15

28544548

-TMEM145chr19

42818424

+
intron-3CDSENST00000563945ENST00000301204HERC2chr15

28544547

-TMEM145chr19

42818423

+
intron-3CDSENST00000563945ENST00000598766HERC2chr15

28544548

-TMEM145chr19

42818424

+
intron-3CDSENST00000563945ENST00000598766HERC2chr15

28544547

-TMEM145chr19

42818423

+
intron-3CDSENST00000563945ENST00000601020HERC2chr15

28544548

-TMEM145chr19

42818424

+
intron-3CDSENST00000563945ENST00000601020HERC2chr15

28544547

-TMEM145chr19

42818423

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261609HERC2chr1528544548-ENST00000301204TMEM145chr1942818424+19032961821657491
ENST00000261609HERC2chr1528544548-ENST00000598766TMEM145chr1942818424+21872961821642486
ENST00000261609HERC2chr1528544548-ENST00000601020TMEM145chr1942818424+6482964700157
ENST00000261609HERC2chr1528544547-ENST00000301204TMEM145chr1942818423+19032961821657491
ENST00000261609HERC2chr1528544547-ENST00000598766TMEM145chr1942818423+21872961821642486
ENST00000261609HERC2chr1528544547-ENST00000601020TMEM145chr1942818423+6482964700157

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261609ENST00000301204HERC2chr1528544548-TMEM145chr1942818424+0.0114023540.98859763
ENST00000261609ENST00000598766HERC2chr1528544548-TMEM145chr1942818424+0.024966840.97503316
ENST00000261609ENST00000601020HERC2chr1528544548-TMEM145chr1942818424+0.102286980.89771307
ENST00000261609ENST00000301204HERC2chr1528544547-TMEM145chr1942818423+0.0114023540.98859763
ENST00000261609ENST00000598766HERC2chr1528544547-TMEM145chr1942818423+0.024966840.97503316
ENST00000261609ENST00000601020HERC2chr1528544547-TMEM145chr1942818423+0.102286980.89771307

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Fusion Genomic Features for HERC2-TMEM145


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HERC2chr1528544547-TMEM145chr1942818423+0.0001265060.9998735
HERC2chr1528544547-TMEM145chr1942818423+0.0001265060.9998735
HERC2chr1528544547-TMEM145chr1942818423+0.0001265060.9998735
HERC2chr1528544547-TMEM145chr1942818423+0.0001265060.9998735

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HERC2-TMEM145


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:28544548/chr19:42818424)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015175_19540494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015207_22740494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015241_26140494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015282_30240494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015318_33840494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015349_36940494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015381_40140494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015175_19540494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015207_22740494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015241_26140494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015282_30240494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015318_33840494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015349_36940494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015381_40140494.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393948_980624835.0Coiled coilOntology_term=ECO:0000255
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393948_980624835.0Coiled coilOntology_term=ECO:0000255
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3931207_1283624835.0DomainCytochrome b5 heme-binding
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3931859_1932624835.0DomainMIB/HERC2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3932759_2936624835.0DomainDOC
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934457_4794624835.0DomainHECT
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3931207_1283624835.0DomainCytochrome b5 heme-binding
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3931859_1932624835.0DomainMIB/HERC2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932759_2936624835.0DomainDOC
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934457_4794624835.0DomainHECT
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3932958_3009624835.0RepeatRCC1 2-1
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933010_3064624835.0RepeatRCC1 2-2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933065_3116624835.0RepeatRCC1 2-3
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933118_3168624835.0RepeatRCC1 2-4
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933171_3222624835.0RepeatRCC1 2-5
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933224_3274624835.0RepeatRCC1 2-6
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933275_3326624835.0RepeatRCC1 2-7
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933951_4002624835.0RepeatRCC1 3-1
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934004_4056624835.0RepeatRCC1 3-2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934058_4108624835.0RepeatRCC1 3-3
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934110_4162624835.0RepeatRCC1 3-4
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393415_461624835.0RepeatRCC1 1-1
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934164_4214624835.0RepeatRCC1 3-5
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934216_4266624835.0RepeatRCC1 3-6
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934268_4318624835.0RepeatRCC1 3-7
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393462_512624835.0RepeatRCC1 1-2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393513_568624835.0RepeatRCC1 1-3
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393569_620624835.0RepeatRCC1 1-4
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393623_674624835.0RepeatRCC1 1-5
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393675_726624835.0RepeatRCC1 1-6
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393728_778624835.0RepeatRCC1 1-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932958_3009624835.0RepeatRCC1 2-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933010_3064624835.0RepeatRCC1 2-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933065_3116624835.0RepeatRCC1 2-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933118_3168624835.0RepeatRCC1 2-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933171_3222624835.0RepeatRCC1 2-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933224_3274624835.0RepeatRCC1 2-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933275_3326624835.0RepeatRCC1 2-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933951_4002624835.0RepeatRCC1 3-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934004_4056624835.0RepeatRCC1 3-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934058_4108624835.0RepeatRCC1 3-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934110_4162624835.0RepeatRCC1 3-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393415_461624835.0RepeatRCC1 1-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934164_4214624835.0RepeatRCC1 3-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934216_4266624835.0RepeatRCC1 3-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934268_4318624835.0RepeatRCC1 3-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393462_512624835.0RepeatRCC1 1-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393513_568624835.0RepeatRCC1 1-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393569_620624835.0RepeatRCC1 1-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393623_674624835.0RepeatRCC1 1-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393675_726624835.0RepeatRCC1 1-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393728_778624835.0RepeatRCC1 1-7
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3932702_2749624835.0Zinc fingerZZ-type
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932702_2749624835.0Zinc fingerZZ-type
TgeneTMEM145chr15:28544547chr19:42818423ENST000003012040159_2940494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST000003012040159_2940494.0TransmembraneHelical


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Fusion Gene Sequence for HERC2-TMEM145


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36168_36168_1_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000301204_length(transcript)=1903nt_BP=296nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGG
ACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGG
TATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGGTGATGGATTGCAGCTGGAGTATGAGATGGTCC
TCACCAATGGCAAGTCCTTCTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCA
TCCTCATCTTCTTCCTCTCTTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAG
CAGGAGTAGAGGTCCTGAGCCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCT
TGGCCAAGCTGCTCTTCTCCTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCA
TCAGCCACGCGGGCTCCGTGAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCT
TTGACCCAGGCCAGGTACTGTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCT
ATGCTGTGCTTGTCTCACTGCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGG
TTCCTGTCATGGCCCTGATTGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGT
ACGCCCATGGCGTGTTTCTGATCATGACCCGCCCATCAGCGGCCAACAAGAACTTCCCGTACCACGTGCGCACGTCGCAGATCGCTTCAG
CCGGAGTCCCTGGACCCGGAGGGAGCCAATCCGCTGACAAGGCCTTCCCGCAGCACGTCTATGGGAACGTGACGTTTATCAGCGACTCGG
TGCCCAACTTCACGGAGCTCTTCTCCATCCCCCCGCCCGCCACCTCCCCCCTGCCCCGAGCGGCGCCGGATTCTGGGCTCCCGCTGTTCC
GTGACCTCCGGCCCCCTGGCCCCCTTCGAGACCTCTGACCCCGCTGGACTCCGGAACACCCGTGGTGACCGCCGGGACCCTGCCTGTGAC
TCTCCAGGACTCTGCGACCCCGGGATGGATATTGCGATGCTGGTCTCGACCCTGAAACCCTCCCTCGGATCTGTGACCTCGGACCCGTAC
TCCATCTGCCGCATCTCCATTCCGGGGGCCTTCCCTCGGGTCCCTGGCAGAAAGACATTTTACCCCTTCTTGCCAAAATAAAAAAGGATT

>36168_36168_1_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000301204_length(amino acids)=491AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKD
CLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFI
LIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRI
SHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLRHFPEKQPFYVPFFAAYTLWFFAV
PVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPGPGGSQSADKAFPQHVYGNVTFISDSV

--------------------------------------------------------------
>36168_36168_2_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000598766_length(transcript)=2187nt_BP=296nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGCTCCCGGTCCCCAACATCTCTGGTCTGCAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGT
GGCCAGCCGTGTACAAGGCAGGGGACAAGGACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCA
CCCAGTATGCCTGGTCCGGCTGTCAGGTGGTATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGC
GTGAACGGTGGTGGTATATTGCGCTCAGCAAGTGTGGGGGTGATGGATTGCAGCTGGAGTATGAGATGGTCCTCACCAATGGCAAGTCCT
TCTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCATCCTCATCTTCTTCCTCT
CTTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAGCAGGAGTAGAGGTCCTGA
GCCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCTTGGCCAAGCTGCTCTTCT
CCTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCATCAGCCACGCGGGCTCCG
TGAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCTTTGACCCAGGCCAGGTAC
TGTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCTATGCTGTGCTTGTCTCAC
TGCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGGTTCCTGTCATGGCCCTGA
TTGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGTACGCCCATGGCGTGTTTC
TGATTCTTCCATTTCTCTTTTGTATCCCCACTGCCTTCCCCACCCTCCTTGATCTCTCCACTCTCCCCCTGCCCCTGCCCAAATTCTGCC
ATCACAGGCCACTGTTCAGGAAGAAGCATCTGGGGTGGCACAGGGTGAAGCTTTTGGGCTCCTGGGTCGGCAACAGGAGGGTACAGCACC
ACATCTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACTAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACCTCCAC
CTCCCAGGTTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGGAGCACGCCACCATGCCCGGTTAAGTGGTTTTTTTTTTTTTTTT
TTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGAGGTGCGATCTCGGCTCACTGCAACTTCTGCCTCCCAAGTTCATGC
CATTCCCCTGCCTCAGCCTCCCTAGTAGCTGGGACTACAGGCGCCCACCACCACGCCTAGCAAATTTTTTTTGTATTTTTAGTAGAGACG
GGGTTTCACTATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGT
GAGCCACTGCGCCTGGCCCCCACCACGTCTATTCTTTGCCCTGGTTCACATCCTATCTGACATTCTTGGTGACAGTTCTAATATTCATTA

>36168_36168_2_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000598766_length(amino acids)=486AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPELPVPNISGLQAKCCQNILLYFDDPSQW
PAVYKAGDKDCLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSVRERWWYIALSKCGGDGLQLEYEMVLTNGKSF
WTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFS
SSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSL
RHFPEKQPFYVPFFAAYTLWFFAVPVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLILPFLFCIPTAFPTLLDLSTLPLPLPKFCH

--------------------------------------------------------------
>36168_36168_3_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000601020_length(transcript)=648nt_BP=296nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGG
ACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGG
TATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGCGTGAACGGTGGTGGTATATTGCGCTCAGCA

>36168_36168_3_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000601020_length(amino acids)=157AA_BP=1
MTPWPGSPCPLPCTRLATGMGHQNRGGCSDSTWPQGSGNGSPVGRNPRGNKILSGTPSPFLGGSSPFWVDSVPVYTISPSLTISFHRPQS

--------------------------------------------------------------
>36168_36168_4_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000301204_length(transcript)=1903nt_BP=296nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGG
ACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGG
TATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGGTGATGGATTGCAGCTGGAGTATGAGATGGTCC
TCACCAATGGCAAGTCCTTCTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCA
TCCTCATCTTCTTCCTCTCTTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAG
CAGGAGTAGAGGTCCTGAGCCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCT
TGGCCAAGCTGCTCTTCTCCTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCA
TCAGCCACGCGGGCTCCGTGAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCT
TTGACCCAGGCCAGGTACTGTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCT
ATGCTGTGCTTGTCTCACTGCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGG
TTCCTGTCATGGCCCTGATTGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGT
ACGCCCATGGCGTGTTTCTGATCATGACCCGCCCATCAGCGGCCAACAAGAACTTCCCGTACCACGTGCGCACGTCGCAGATCGCTTCAG
CCGGAGTCCCTGGACCCGGAGGGAGCCAATCCGCTGACAAGGCCTTCCCGCAGCACGTCTATGGGAACGTGACGTTTATCAGCGACTCGG
TGCCCAACTTCACGGAGCTCTTCTCCATCCCCCCGCCCGCCACCTCCCCCCTGCCCCGAGCGGCGCCGGATTCTGGGCTCCCGCTGTTCC
GTGACCTCCGGCCCCCTGGCCCCCTTCGAGACCTCTGACCCCGCTGGACTCCGGAACACCCGTGGTGACCGCCGGGACCCTGCCTGTGAC
TCTCCAGGACTCTGCGACCCCGGGATGGATATTGCGATGCTGGTCTCGACCCTGAAACCCTCCCTCGGATCTGTGACCTCGGACCCGTAC
TCCATCTGCCGCATCTCCATTCCGGGGGCCTTCCCTCGGGTCCCTGGCAGAAAGACATTTTACCCCTTCTTGCCAAAATAAAAAAGGATT

>36168_36168_4_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000301204_length(amino acids)=491AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKD
CLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFI
LIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRI
SHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLRHFPEKQPFYVPFFAAYTLWFFAV
PVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPGPGGSQSADKAFPQHVYGNVTFISDSV

--------------------------------------------------------------
>36168_36168_5_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000598766_length(transcript)=2187nt_BP=296nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGCTCCCGGTCCCCAACATCTCTGGTCTGCAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGT
GGCCAGCCGTGTACAAGGCAGGGGACAAGGACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCA
CCCAGTATGCCTGGTCCGGCTGTCAGGTGGTATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGC
GTGAACGGTGGTGGTATATTGCGCTCAGCAAGTGTGGGGGTGATGGATTGCAGCTGGAGTATGAGATGGTCCTCACCAATGGCAAGTCCT
TCTGGACACGACACTTCTCCGCTGATGAGTTTGGGATCCTGGAGACAGATGTGACCTTCCTCCTCATCTTCATCCTCATCTTCTTCCTCT
CTTGTTACTTTGGATATTTGCTGAAAGGTCGTCAGTTGCTCCACACAACTTATAAAATGTTCATGGCCGCAGCAGGAGTAGAGGTCCTGA
GCCTCCTATTTTTCTGCATCTACTGGGGTCAATATGCCACCGATGGCATTGGCAACGAGAGTGTGAAGATCTTGGCCAAGCTGCTCTTCT
CCTCCAGCTTCCTCATCTTCCTGCTGATGCTTATCCTCCTGGGGAAGGGATTCACGGTGACACGGGGCCGCATCAGCCACGCGGGCTCCG
TGAAGTTGTCTGTCTACATGACCCTGTACACGCTCACCCATGTGGTGCTGCTCATCTACGAGGCGGAATTCTTTGACCCAGGCCAGGTAC
TGTACACGTATGAGTCGCCGGCCGGCTACGGGCTCATTGGACTGCAGGTGGCGGCCTACGTGTGGTTCTGCTATGCTGTGCTTGTCTCAC
TGCGACACTTTCCTGAGAAGCAGCCTTTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCGGTTCCTGTCATGGCCCTGA
TTGCCAATTTCGGCATCCCCAAGTGGGCCCGGGAGAAGATTGTCAATGGCATCCAGCTGGGGATCCACTTGTACGCCCATGGCGTGTTTC
TGATTCTTCCATTTCTCTTTTGTATCCCCACTGCCTTCCCCACCCTCCTTGATCTCTCCACTCTCCCCCTGCCCCTGCCCAAATTCTGCC
ATCACAGGCCACTGTTCAGGAAGAAGCATCTGGGGTGGCACAGGGTGAAGCTTTTGGGCTCCTGGGTCGGCAACAGGAGGGTACAGCACC
ACATCTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACTAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACCTCCAC
CTCCCAGGTTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGACTACAGGAGCACGCCACCATGCCCGGTTAAGTGGTTTTTTTTTTTTTTTT
TTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGAGGTGCGATCTCGGCTCACTGCAACTTCTGCCTCCCAAGTTCATGC
CATTCCCCTGCCTCAGCCTCCCTAGTAGCTGGGACTACAGGCGCCCACCACCACGCCTAGCAAATTTTTTTTGTATTTTTAGTAGAGACG
GGGTTTCACTATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGT
GAGCCACTGCGCCTGGCCCCCACCACGTCTATTCTTTGCCCTGGTTCACATCCTATCTGACATTCTTGGTGACAGTTCTAATATTCATTA

>36168_36168_5_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000598766_length(amino acids)=486AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPELPVPNISGLQAKCCQNILLYFDDPSQW
PAVYKAGDKDCLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSVRERWWYIALSKCGGDGLQLEYEMVLTNGKSF
WTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFS
SSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSL
RHFPEKQPFYVPFFAAYTLWFFAVPVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLILPFLFCIPTAFPTLLDLSTLPLPLPKFCH

--------------------------------------------------------------
>36168_36168_6_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000601020_length(transcript)=648nt_BP=296nt
GCGCCGGCTGAGCCAGCGGCTCTTGGGAGGCTGCGTCCGCGCGCCGGCGAGGCGAGGCGGCCGGGCCCTGCGCGTCAGGCCTGAGACCTG
GGAGGAAGCTGGAGAAAAGATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAAACAGATATACA
GCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTTAAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCA
GAACGGAGAGCTCCCTCCTAGAAAAGGACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTACGGCCGACTGGACTTCCGTTTCC
GCTACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGATGACCCATCCCAGTGGCCAGCCGTGTACAAGGCAGGGGACAAGG
ACTGCCTGGCCAAGGAGTCAGTGATCCGGCCGGAGAACAACCAGGTCATCAACCTCACCACCCAGTATGCCTGGTCCGGCTGTCAGGTGG
TATCAGAGGAGGGAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCAGTGCGTGAACGGTGGTGGTATATTGCGCTCAGCA

>36168_36168_6_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000601020_length(amino acids)=157AA_BP=1
MTPWPGSPCPLPCTRLATGMGHQNRGGCSDSTWPQGSGNGSPVGRNPRGNKILSGTPSPFLGGSSPFWVDSVPVYTISPSLTISFHRPQS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HERC2-TMEM145


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HERC2-TMEM145


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HERC2-TMEM145


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource