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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HERC4-RUFY2 (FusionGDB2 ID:36185)

Fusion Gene Summary for HERC4-RUFY2

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC4-RUFY2
Fusion gene ID: 36185
HgeneTgene
Gene symbol

HERC4

RUFY2

Gene ID

26091

55680

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 4RUN and FYVE domain containing 2
Synonyms-RABIP4R|ZFYVE13
Cytomap

10q21.3

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC4HECT domain and RCC1-like domain-containing protein 4HECT-type E3 ubiquitin transferase HERC4hect domain and RLD 4RUN and FYVE domain-containing protein 2Run- and FYVE-domain containing proteinantigen MU-RMS-40.17rab4-interacting protein related
Modification date2020032720200313
UniProtAcc

Q5GLZ8

.
Ensembl transtripts involved in fusion geneENST00000395187, ENST00000277817, 
ENST00000373700, ENST00000395198, 
ENST00000412272, ENST00000480158, 
ENST00000492996, 		ENST00000265865, 
ENST00000388768, ENST00000602465, 
ENST00000342616, ENST00000399200, 
ENST00000454950, ENST00000472394, 
Fusion gene scores* DoF score12 X 13 X 6=9369 X 9 X 5=405
# samples 1511
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/405*10)=-1.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HERC4 [Title/Abstract] AND RUFY2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHERC4(69792535)-RUFY2(70105668), # samples:3
Anticipated loss of major functional domain due to fusion event.HERC4-RUFY2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HERC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RUFY2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0U4-01AHERC4chr10

69792535

-RUFY2chr10

70105668

-
ChimerDB4BRCATCGA-AR-A0U4HERC4chr10

69792534

-RUFY2chr10

70105668

-
ChimerDB4STADTCGA-BR-8373-01AHERC4chr10

69785303

-RUFY2chr10

70136729

-


Top

Fusion Gene ORF analysis for HERC4-RUFY2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395187ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-3CDSENST00000395187ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-3CDSENST00000395187ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-3CDSENST00000395187ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-3CDSENST00000395187ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
3UTR-3CDSENST00000395187ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-3CDSENST00000395187ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-3CDSENST00000395187ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
3UTR-5UTRENST00000395187ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
3UTR-intronENST00000395187ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
3UTR-intronENST00000395187ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
3UTR-intronENST00000395187ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
3UTR-intronENST00000395187ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
3UTR-intronENST00000395187ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-5UTRENST00000277817ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-5UTRENST00000373700ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-5UTRENST00000395198ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-5UTRENST00000412272ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000277817ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000277817ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000277817ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000277817ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000277817ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000373700ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000373700ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000373700ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000373700ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000373700ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000395198ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000395198ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000395198ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000395198ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000395198ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000412272ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000412272ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000412272ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
5CDS-intronENST00000412272ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
5CDS-intronENST00000412272ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-
Frame-shiftENST00000277817ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000277817ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000277817ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000277817ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000373700ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000373700ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000373700ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
Frame-shiftENST00000373700ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000373700ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000373700ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
Frame-shiftENST00000395198ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000395198ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000395198ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
Frame-shiftENST00000395198ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000395198ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000395198ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
Frame-shiftENST00000412272ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000412272ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000412272ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
Frame-shiftENST00000412272ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
Frame-shiftENST00000412272ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
Frame-shiftENST00000412272ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
In-frameENST00000277817ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
In-frameENST00000277817ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
In-frameENST00000277817ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
In-frameENST00000277817ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
In-frameENST00000373700ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
In-frameENST00000373700ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
In-frameENST00000395198ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
In-frameENST00000395198ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
In-frameENST00000412272ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
In-frameENST00000412272ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-3CDSENST00000480158ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000480158ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-3CDSENST00000492996ENST00000265865HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-3CDSENST00000492996ENST00000265865HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000492996ENST00000388768HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-3CDSENST00000492996ENST00000388768HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000492996ENST00000388768HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-3CDSENST00000492996ENST00000602465HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-3CDSENST00000492996ENST00000602465HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-3CDSENST00000492996ENST00000602465HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-5UTRENST00000480158ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-5UTRENST00000492996ENST00000265865HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000480158ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000480158ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000480158ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000480158ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000480158ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000492996ENST00000342616HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000342616HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000342616HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000492996ENST00000399200HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000399200HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000399200HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000492996ENST00000454950HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000454950HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000454950HERC4chr10

69785303

-RUFY2chr10

70136729

-
intron-intronENST00000492996ENST00000472394HERC4chr10

69792535

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000472394HERC4chr10

69792534

-RUFY2chr10

70105668

-
intron-intronENST00000492996ENST00000472394HERC4chr10

69785303

-RUFY2chr10

70136729

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277817HERC4chr1069792535-ENST00000388768RUFY2chr1070105668-33459424951085196
ENST00000412272HERC4chr1069792535-ENST00000265865RUFY2chr1070105668-179210252481168306
ENST00000395198HERC4chr1069792535-ENST00000265865RUFY2chr1070105668-179210252481168306
ENST00000373700HERC4chr1069792535-ENST00000265865RUFY2chr1070105668-185710903131233306
ENST00000277817HERC4chr1069792534-ENST00000388768RUFY2chr1070105668-33459424951085196
ENST00000412272HERC4chr1069792534-ENST00000265865RUFY2chr1070105668-179210252481168306
ENST00000395198HERC4chr1069792534-ENST00000265865RUFY2chr1070105668-179210252481168306
ENST00000373700HERC4chr1069792534-ENST00000265865RUFY2chr1070105668-185710903131233306
ENST00000277817HERC4chr1069785303-ENST00000388768RUFY2chr1070136729-394810734951688397
ENST00000277817HERC4chr1069785303-ENST00000602465RUFY2chr1070136729-363010734951688397

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277817ENST00000388768HERC4chr1069792535-RUFY2chr1070105668-0.0036938290.9963062
ENST00000412272ENST00000265865HERC4chr1069792535-RUFY2chr1070105668-0.0004088360.9995912
ENST00000395198ENST00000265865HERC4chr1069792535-RUFY2chr1070105668-0.0004088360.9995912
ENST00000373700ENST00000265865HERC4chr1069792535-RUFY2chr1070105668-0.0004208770.99957913
ENST00000277817ENST00000388768HERC4chr1069792534-RUFY2chr1070105668-0.0036938290.9963062
ENST00000412272ENST00000265865HERC4chr1069792534-RUFY2chr1070105668-0.0004088360.9995912
ENST00000395198ENST00000265865HERC4chr1069792534-RUFY2chr1070105668-0.0004088360.9995912
ENST00000373700ENST00000265865HERC4chr1069792534-RUFY2chr1070105668-0.0004208770.99957913
ENST00000277817ENST00000388768HERC4chr1069785303-RUFY2chr1070136729-0.0002732170.9997267
ENST00000277817ENST00000602465HERC4chr1069785303-RUFY2chr1070136729-0.0003330570.9996669

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Fusion Genomic Features for HERC4-RUFY2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HERC4-RUFY2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:69792535/chr10:70105668)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC4

Q5GLZ8

.
FUNCTION: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-724730_1057249123.66666666666667DomainHECT
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-624730_1057205123.66666666666667DomainHECT
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-624730_1057205123.66666666666667DomainHECT
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-523102_154192948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-5231_51192948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-52352_101192948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-825102_1543021050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-825156_2073021050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-8251_513021050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-825208_2593021050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-82552_1013021050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-724102_154249123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-724156_207249123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-7241_51249123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-724208_259249123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-724261_311249123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-724313_368249123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69785303chr10:70136729ENST00000395187-72452_101249123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-826102_1543021058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-826156_2073021058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-8261_513021058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-826208_2593021058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-82652_1013021058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-824102_154302980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-824156_207302980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-8241_51302980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-824208_259302980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-82452_101302980.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-4231_51149948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-42352_101149948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-725102_1542591050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-725156_2072591050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-7251_512591050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-725208_2592591050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-72552_1012591050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-624102_154205123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-624156_207205123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-6241_51205123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-624208_259205123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-624261_311205123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-624313_368205123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr10:70105668ENST00000395187-62452_101205123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-726102_1542591058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-726156_2072591058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-7261_512591058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-726208_2592591058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-72652_1012591058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-724102_154259980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-724156_207259980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-7241_51259980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-724208_259259980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-72452_101259980.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-4231_51149948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-42352_101149948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-725102_1542591050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-725156_2072591050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-7251_512591050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-725208_2592591050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-72552_1012591050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-624102_154205123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-624156_207205123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-6241_51205123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-624208_259205123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-624261_311205123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-624313_368205123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr10:70105668ENST00000395187-62452_101205123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-726102_1542591058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-726156_2072591058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-7261_512591058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-726208_2592591058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-72652_1012591058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-724102_154259980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-724156_207259980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-7241_51259980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-724208_259259980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-72452_101259980.0RepeatNote=RCC1 2
TgeneRUFY2chr10:69785303chr10:70136729ENST00000399200012210_5340404.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69792534chr10:70105668ENST00000399200012210_5340404.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69792535chr10:70105668ENST00000399200012210_5340404.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69785303chr10:70136729ENST0000039920001237_1690404.0DomainRUN
TgeneRUFY2chr10:69792534chr10:70105668ENST0000039920001237_1690404.0DomainRUN
TgeneRUFY2chr10:69792535chr10:70105668ENST0000039920001237_1690404.0DomainRUN
TgeneRUFY2chr10:69785303chr10:70136729ENST000003887681118540_598436642.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69785303chr10:70136729ENST00000399200012540_5980404.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69785303chr10:70136729ENST000006024651118540_598401607.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69792534chr10:70105668ENST00000399200012540_5980404.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69792535chr10:70105668ENST00000399200012540_5980404.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-523730_1057192948.0DomainHECT
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-825730_10573021050.0DomainHECT
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-826730_10573021058.0DomainHECT
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-824730_1057302980.0DomainHECT
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-423730_1057149948.0DomainHECT
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-725730_10572591050.0DomainHECT
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-726730_10572591058.0DomainHECT
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-724730_1057259980.0DomainHECT
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-423730_1057149948.0DomainHECT
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-725730_10572591050.0DomainHECT
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-726730_10572591058.0DomainHECT
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-724730_1057259980.0DomainHECT
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-523156_207192948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-523208_259192948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-523261_311192948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69785303chr10:70136729ENST00000277817-523313_368192948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-825261_3113021050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69785303chr10:70136729ENST00000373700-825313_3683021050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-826261_3113021058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69785303chr10:70136729ENST00000395198-826313_3683021058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-824261_311302980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69785303chr10:70136729ENST00000412272-824313_368302980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69785303chr10:70136729ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-423102_154149948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-423156_207149948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-423208_259149948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-423261_311149948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr10:70105668ENST00000277817-423313_368149948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-725261_3112591050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr10:70105668ENST00000373700-725313_3682591050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-726261_3112591058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr10:70105668ENST00000395198-726313_3682591058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-724261_311259980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr10:70105668ENST00000412272-724313_368259980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr10:70105668ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-423102_154149948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-423156_207149948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-423208_259149948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-423261_311149948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr10:70105668ENST00000277817-423313_368149948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-725261_3112591050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr10:70105668ENST00000373700-725313_3682591050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-726261_3112591058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr10:70105668ENST00000395198-726313_3682591058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-724261_311259980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr10:70105668ENST00000412272-724313_368259980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr10:70105668ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
TgeneRUFY2chr10:69785303chr10:70136729ENST000003887681118210_534436642.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69785303chr10:70136729ENST000006024651118210_534401607.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69792534chr10:70105668ENST000003887681618210_534594642.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69792534chr10:70105668ENST000006024651618210_534559607.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69792535chr10:70105668ENST000003887681618210_534594642.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69792535chr10:70105668ENST000006024651618210_534559607.0Coiled coilOntology_term=ECO:0000255
TgeneRUFY2chr10:69785303chr10:70136729ENST00000388768111837_169436642.0DomainRUN
TgeneRUFY2chr10:69785303chr10:70136729ENST00000602465111837_169401607.0DomainRUN
TgeneRUFY2chr10:69792534chr10:70105668ENST00000388768161837_169594642.0DomainRUN
TgeneRUFY2chr10:69792534chr10:70105668ENST00000602465161837_169559607.0DomainRUN
TgeneRUFY2chr10:69792535chr10:70105668ENST00000388768161837_169594642.0DomainRUN
TgeneRUFY2chr10:69792535chr10:70105668ENST00000602465161837_169559607.0DomainRUN
TgeneRUFY2chr10:69792534chr10:70105668ENST000003887681618540_598594642.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69792534chr10:70105668ENST000006024651618540_598559607.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69792535chr10:70105668ENST000003887681618540_598594642.0Zinc fingerFYVE-type
TgeneRUFY2chr10:69792535chr10:70105668ENST000006024651618540_598559607.0Zinc fingerFYVE-type


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Fusion Gene Sequence for HERC4-RUFY2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36185_36185_1_HERC4-RUFY2_HERC4_chr10_69785303_ENST00000277817_RUFY2_chr10_70136729_ENST00000388768_length(transcript)=3948nt_BP=1073nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAGGTGGAGTGTTTACTTTTGGAGCTGGAGGGTATGGTCAGTTGGGC
CATAATTCTACCAGTCATGAAATAAACCCAAGGAAAGTTTTTGAACTTATGGGAAGCATTGTCACTGAGATTGCTTGTGGACGATTGCAG
CAAGCAGAGAAGGCGCAAATGGAAGCTGAAGATGAGGATGAGAAATATCTACAAGAATGTCTCAGTAAATCTGATAGTCTGCAGAAACAA
ATCTCCCAAAAGGAGAAACAGCTGGTGCAACTGGAAACTGACTTGAAGATTGAGAAGGAATGGAGGCAGACTTTGCAGGAAGATCTTCAA
AAGGAGAAAGATGCCTTATCTCATCTTAGAAATGAGACTCAACAAATCATTAGTCTTAAAAAAGAGTTCCTTAACCTCCAGGATGAAAAT
CAGCAGTTGAAAAAAATATATCATGAACAAGAGCAAGCTCTTCAAGAACTCGGCAACAAGCTTAGCGAATCAAAACTTAAAATTGAAGAC
ATAAAAGAAGCCAACAAAGCATTGCAGGGACTGGTTTGGCTGAAAGACAAAGAAGCAACACATTGTAAACTTTGTGAAAAGGAATTCTCA
CTCTCTAAGAGAAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAACTACCTTTGCCTTCTTCACCA
AAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAGACTCCAGAACTAAATCCTTA
TGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCGGCTTTCGGTCAGTATTTGGT
ACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTCAAAATGTATTTTCAACAGAG
CATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTAAAGGCCTTAAAAATAAGGCT
TCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCACTTTAAAGCTTCACAGTTCTG
AAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAAGATTTCAACTATATTTATTT
GCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTTCCTCTTGGTCTCTTTAAAAA
TCAGTTATTGTCGTGCTTGCTGAAGATTTTCAGCTACAGTGGATTAAATTAAAGGGGGCATTATTTGGCCTCGGCCTCTACTTTTTTCCT
TTTAATCTTGAAAGGAAGTTACATATAACCATCTTTCTTTTCCTGATTTATAAATCTTCCCATATGCTGTTTCATTAAATTGCTGTTTTT
TTAAGGGGTGACTCAGACCCCAATTCAAAGATGAAAACACAAATCCTTCCCCAGAAAAAAAAGTATGTAATAGTAGGGGATGTTACAGGC
TCCTTATAAAGGTCCTCTCCTCTAAGCATTAAAAGTGAGAAAAAAATCAGGACTTTGCTTTGGTAATGTATTAGAGTTCAGTTCAAAAAA
TTTTGTATTAACATTTTCATTGGAGTAAATTTTAGGAAGTATCACATTGTAGTGGCCTACCTGTATACATCCACAGTAAAATTTCACCAT
GTCCATTGAGCACCTCTATGCCAAGGGTGTTGAGATGATGAAATATACACTTGACCTATTTCTTTTTTTTTCGAGATGGAGTTTCACTCT
TGTTGCCTAGGCTGGAGTGCAATGGCACGATCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAC
AGGCGTGAGCCACAGCACCTGGCCAGTACACTTGACCTATTTCAAGCTGACTCAATGAACACTAATCCAAGTTATATTGCTTATGGCATA
CTAAGAATTTAACTTGTATAAATTACCTCTGAATAGTTACATAAACACTATCACCATTCAGTATCCTATTTTTTACATTAATTTTTAACC
ATGCACTTTAAGTTTGTGAGCCTATAAAAAATACATAGAAAATTTATGGATTAAGAGCATTATATTTAGTGGTTAATCCTAGGTACCTCC
CTGCCTACAAAGGAGTTCTTATTAATACTGCAGGATCTTTTCTTCATGAATATATGCTTCCATGAAATTTAAATTTTTCTGAATAGCCTA
AGTATGAAATGAATATTTTACTTGAAGATCTATTTTTTCCAAAACCCGTAAATTTCCAGTCAGCTTTTGAGGTGTCAGATGTGACACAGA
TTTCTAGATGGTCTTTCTTGAATACTGACAGAAATGTCCTCAAGAGAGGATTATATTCTTGAACCATTTTGTATTGATAGGTGGGATGGG
CTAACATTTTTATGATTACTGAATAAACAAAAAATGAAATTTTCAAATATGCTTTTTTATTACTGTGCTTAGAACAAATTTTAAAATGTG
ACTTAAGTTGCTTAAATTCCAAGGCTAATTTCATTCAACAAACCATGATTTTGTCATCCTTTAAGTAAGTTTCTCACTTTTCAAAACTCA
TGTATCAACACTGACTGACTTGCTTTTTTTTTTTTTTTTTTTTTTTTTAGGCAGCTTTTATGACAGCAACTTGCTCCATGTAGTTTTGGC
TTATTTAAAAACTATACTAACTTTGGATTTTTCTGTTACAAGACTTTTAACAATCTGTATTTCGTGATTGTGAACTCGTATTCATTTTAC
TTTTCAAAAACAGACTTAACATACCATTCCCTCACCTAGCAGTACTACCACAATAATGCTATCATGGTGCCAGGGAATTACAATTGTAAT

>36185_36185_1_HERC4-RUFY2_HERC4_chr10_69785303_ENST00000277817_RUFY2_chr10_70136729_ENST00000388768_length(amino acids)=397AA_BP=192
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE
LMGSIVTEIACGRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQ
IISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIF

--------------------------------------------------------------
>36185_36185_2_HERC4-RUFY2_HERC4_chr10_69785303_ENST00000277817_RUFY2_chr10_70136729_ENST00000602465_length(transcript)=3630nt_BP=1073nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAGGTGGAGTGTTTACTTTTGGAGCTGGAGGGTATGGTCAGTTGGGC
CATAATTCTACCAGTCATGAAATAAACCCAAGGAAAGTTTTTGAACTTATGGGAAGCATTGTCACTGAGATTGCTTGTGGACGATTGCAG
CAAGCAGAGAAGGCGCAAATGGAAGCTGAAGATGAGGATGAGAAATATCTACAAGAATGTCTCAGTAAATCTGATAGTCTGCAGAAACAA
ATCTCCCAAAAGGAGAAACAGCTGGTGCAACTGGAAACTGACTTGAAGATTGAGAAGGAATGGAGGCAGACTTTGCAGGAAGATCTTCAA
AAGGAGAAAGATGCCTTATCTCATCTTAGAAATGAGACTCAACAAATCATTAGTCTTAAAAAAGAGTTCCTTAACCTCCAGGATGAAAAT
CAGCAGTTGAAAAAAATATATCATGAACAAGAGCAAGCTCTTCAAGAACTCGGCAACAAGCTTAGCGAATCAAAACTTAAAATTGAAGAC
ATAAAAGAAGCCAACAAAGCATTGCAGGGACTGGTTTGGCTGAAAGACAAAGAAGCAACACATTGTAAACTTTGTGAAAAGGAATTCTCA
CTCTCTAAGAGAAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAACTACCTTTGCCTTCTTCACCA
AAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAGACTCCAGAACTAAATCCTTA
TGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCGGCTTTCGGTCAGTATTTGGT
ACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTCAAAATGTATTTTCAACAGAG
CATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTAAAGGCCTTAAAAATAAGGCT
TCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCACTTTAAAGCTTCACAGTTCTG
AAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAAGATTTCAACTATATTTATTT
GCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTTCCTCTTGGTCTCTTTAAAAA
TCAGTTATTGTCGTGCTTGCTGAAGATTTTCAGCTACAGTGGATTAAATTAAAGGGGGCATTATTTGGCCTCGGCCTCTACTTTTTTCCT
TTTAATCTTGAAAGGAAGTTACATATAACCATCTTTCTTTTCCTGATTTATAAATCTTCCCATATGCTGTTTCATTAAATTGCTGTTTTT
TTAAGGGGTGACTCAGACCCCAATTCAAAGATGAAAACACAAATCCTTCCCCAGAAAAAAAAGTATGTAATAGTAGGGGATGTTACAGGC
TCCTTATAAAGGTCCTCTCCTCTAAGCATTAAAAGTGAGAAAAAAATCAGGACTTTGCTTTGGTAATGTATTAGAGTTCAGTTCAAAAAA
TTTTGTATTAACATTTTCATTGGAGTAAATTTTAGGAAGTATCACATTGTAGTGGCCTACCTGTATACATCCACAGTAAAATTTCACCAT
GTCCATTGAGCACCTCTATGCCAAGGGTGTTGAGATGATGAAATATACACTTGACCTATTTCTTTTTTTTTCGAGATGGAGTTTCACTCT
TGTTGCCTAGGCTGGAGTGCAATGGCACGATCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTAC
AGGCGTGAGCCACAGCACCTGGCCAGTACACTTGACCTATTTCAAGCTGACTCAATGAACACTAATCCAAGTTATATTGCTTATGGCATA
CTAAGAATTTAACTTGTATAAATTACCTCTGAATAGTTACATAAACACTATCACCATTCAGTATCCTATTTTTTACATTAATTTTTAACC
ATGCACTTTAAGTTTGTGAGCCTATAAAAAATACATAGAAAATTTATGGATTAAGAGCATTATATTTAGTGGTTAATCCTAGGTACCTCC
CTGCCTACAAAGGAGTTCTTATTAATACTGCAGGATCTTTTCTTCATGAATATATGCTTCCATGAAATTTAAATTTTTCTGAATAGCCTA
AGTATGAAATGAATATTTTACTTGAAGATCTATTTTTTCCAAAACCCGTAAATTTCCAGTCAGCTTTTGAGGTGTCAGATGTGACACAGA
TTTCTAGATGGTCTTTCTTGAATACTGACAGAAATGTCCTCAAGAGAGGATTATATTCTTGAACCATTTTGTATTGATAGGTGGGATGGG
CTAACATTTTTATGATTACTGAATAAACAAAAAATGAAATTTTCAAATATGCTTTTTTATTACTGTGCTTAGAACAAATTTTAAAATGTG
ACTTAAGTTGCTTAAATTCCAAGGCTAATTTCATTCAACAAACCATGATTTTGTCATCCTTTAAGTAAGTTTCTCACTTTTCAAAACTCA

>36185_36185_2_HERC4-RUFY2_HERC4_chr10_69785303_ENST00000277817_RUFY2_chr10_70136729_ENST00000602465_length(amino acids)=397AA_BP=192
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE
LMGSIVTEIACGRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQ
IISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIF

--------------------------------------------------------------
>36185_36185_3_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000277817_RUFY2_chr10_70105668_ENST00000388768_length(transcript)=3345nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGAC
AACGAACTACCTTTGCCTTCTTCACCAAAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTG
CCCTGAGACTCCAGAACTAAATCCTTATGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCC
TTAAGCGGCTTTCGGTCAGTATTTGGTACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATT
GTTTTTCAAAATGTATTTTCAACAGAGCATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTA
TCTTGTAAAGGCCTTAAAAATAAGGCTTCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTT
AATGCACTTTAAAGCTTCACAGTTCTGAAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATC
TTTGTAAGATTTCAACTATATTTATTTGCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTAC
AAAATTTCCTCTTGGTCTCTTTAAAAATCAGTTATTGTCGTGCTTGCTGAAGATTTTCAGCTACAGTGGATTAAATTAAAGGGGGCATTA
TTTGGCCTCGGCCTCTACTTTTTTCCTTTTAATCTTGAAAGGAAGTTACATATAACCATCTTTCTTTTCCTGATTTATAAATCTTCCCAT
ATGCTGTTTCATTAAATTGCTGTTTTTTTAAGGGGTGACTCAGACCCCAATTCAAAGATGAAAACACAAATCCTTCCCCAGAAAAAAAAG
TATGTAATAGTAGGGGATGTTACAGGCTCCTTATAAAGGTCCTCTCCTCTAAGCATTAAAAGTGAGAAAAAAATCAGGACTTTGCTTTGG
TAATGTATTAGAGTTCAGTTCAAAAAATTTTGTATTAACATTTTCATTGGAGTAAATTTTAGGAAGTATCACATTGTAGTGGCCTACCTG
TATACATCCACAGTAAAATTTCACCATGTCCATTGAGCACCTCTATGCCAAGGGTGTTGAGATGATGAAATATACACTTGACCTATTTCT
TTTTTTTTCGAGATGGAGTTTCACTCTTGTTGCCTAGGCTGGAGTGCAATGGCACGATCTCCACCTCCTGGGTTCAAGCAATTCTCCTGC
CTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGAGCCACAGCACCTGGCCAGTACACTTGACCTATTTCAAGCTGACTCAATGAACACT
AATCCAAGTTATATTGCTTATGGCATACTAAGAATTTAACTTGTATAAATTACCTCTGAATAGTTACATAAACACTATCACCATTCAGTA
TCCTATTTTTTACATTAATTTTTAACCATGCACTTTAAGTTTGTGAGCCTATAAAAAATACATAGAAAATTTATGGATTAAGAGCATTAT
ATTTAGTGGTTAATCCTAGGTACCTCCCTGCCTACAAAGGAGTTCTTATTAATACTGCAGGATCTTTTCTTCATGAATATATGCTTCCAT
GAAATTTAAATTTTTCTGAATAGCCTAAGTATGAAATGAATATTTTACTTGAAGATCTATTTTTTCCAAAACCCGTAAATTTCCAGTCAG
CTTTTGAGGTGTCAGATGTGACACAGATTTCTAGATGGTCTTTCTTGAATACTGACAGAAATGTCCTCAAGAGAGGATTATATTCTTGAA
CCATTTTGTATTGATAGGTGGGATGGGCTAACATTTTTATGATTACTGAATAAACAAAAAATGAAATTTTCAAATATGCTTTTTTATTAC
TGTGCTTAGAACAAATTTTAAAATGTGACTTAAGTTGCTTAAATTCCAAGGCTAATTTCATTCAACAAACCATGATTTTGTCATCCTTTA
AGTAAGTTTCTCACTTTTCAAAACTCATGTATCAACACTGACTGACTTGCTTTTTTTTTTTTTTTTTTTTTTTTTAGGCAGCTTTTATGA
CAGCAACTTGCTCCATGTAGTTTTGGCTTATTTAAAAACTATACTAACTTTGGATTTTTCTGTTACAAGACTTTTAACAATCTGTATTTC
GTGATTGTGAACTCGTATTCATTTTACTTTTCAAAAACAGACTTAACATACCATTCCCTCACCTAGCAGTACTACCACAATAATGCTATC
ATGGTGCCAGGGAATTACAATTGTAATTCTTCTAACCTATAATGTTTAAAAAATAAAATGTGAATTTTATGAACTAAATAAATATTTGGA

>36185_36185_3_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000277817_RUFY2_chr10_70105668_ENST00000388768_length(amino acids)=196AA_BP=134
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFCNACSDNELPLPSSPKPVRVC

--------------------------------------------------------------
>36185_36185_4_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000373700_RUFY2_chr10_70105668_ENST00000265865_length(transcript)=1857nt_BP=1090nt
ACTTCCGGCCAGCCCCTCCCCCGCCTCCCTCGCGTGGCCACCTCCCCCTCTGCCTTCTCCTACCCAGTCTCTTCCCCAACTCTCCCCACC
CCTGGTGCTCTCCGCCCCGCTTGCCTCCCGTTCTTCCCCGCCCGCTCCATCCGGGTCGCTGACGGCTGTCTCTGGACTGGACAGCAGTGG
CGTCCGCTTTTCTCTAAGGAACCCGATAAGAACTCCATTTTCTGTTGATGTGGAGACATAGGGTACCTCCAACTTTCCGGGGTTTCAGAA
GAGAATTTTTTATTGAAACTGGAAGACCAAAATAATTACAAGCATGTTGTGCTGGGGAAATGCATCCTTTGGGCAGCTAGGTTTGGGTGG
AATTGATGAAGAAATTGTACTAGAGCCCAGAAAAAGTGACTTCTTTATAAATAAAAGGGTCCGAGATGTAGGATGTGGACTCAGACATAC
TGTGTTTGTTCTGGATGATGGAACAGTGTACACATGTGGATGTAATGATCTAGGACAGCTAGGTCATGAAAAATCCAGAAAGAAACCAGA
GCAGGTTGTTGCCCTGGATGCCCAAAATATTGTAGCTGTTTCATGTGGAGAAGCTCATACGTTAGCGCTAAATGACAAAGGCCAGGTGTA
TGCTTGGGGTCTCGATTCTGATGGACAGCTTGGCCTGGTAGGATCAGAGGAATGCATCAGAGTACCCAGAAATATTAAAAGTTTGTCAGA
TATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCAAGTGAAGTCTTCTGTTGGGGACAGAATAAATA
TGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAGTCTTTGCTTGGAATCCCTTTCATGCAAGTTGC
AGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGACGCAACAAGTTTGGTCAGCTAGGTCTTAATGA
TGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTTTATATTTGTTGTGGAGAAGATCATACTGCTGC
TCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAACTACCTTTGCCTTCTTCACCAAAACC
AGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAGACTCCAGAACTAAATCCTTATGTAT
GAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCGGCTTTCGGTCAGTATTTGGTACCAG
TTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTCAAAATGTATTTTCAACAGAGCATGC
TTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTAAAGGCCTTAAAAATAAGGCTTCAGA
TTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCACTTTAAAGCTTCACAGTTCTGAAACT
GGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAAGATTTCAACTATATTTATTTGCCCT
TTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTTCCTCTTGGTCTCTTTAAAAATCAGT

>36185_36185_4_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000373700_RUFY2_chr10_70105668_ENST00000265865_length(amino acids)=306AA_BP=244
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFC

--------------------------------------------------------------
>36185_36185_5_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000395198_RUFY2_chr10_70105668_ENST00000265865_length(transcript)=1792nt_BP=1025nt
AGTCTCTTCCCCAACTCTCCCCACCCCTGGTGCTCTCCGCCCCGCTTGCCTCCCGTTCTTCCCCGCCCGCTCCATCCGGGTCGCTGACGG
CTGTCTCTGGACTGGACAGCAGTGGCGTCCGCTTTTCTCTAAGGAACCCGATAAGAACTCCATTTTCTGTTGATGTGGAGACATAGGGTA
CCTCCAACTTTCCGGGGTTTCAGAAGAGAATTTTTTATTGAAACTGGAAGACCAAAATAATTACAAGCATGTTGTGCTGGGGAAATGCAT
CCTTTGGGCAGCTAGGTTTGGGTGGAATTGATGAAGAAATTGTACTAGAGCCCAGAAAAAGTGACTTCTTTATAAATAAAAGGGTCCGAG
ATGTAGGATGTGGACTCAGACATACTGTGTTTGTTCTGGATGATGGAACAGTGTACACATGTGGATGTAATGATCTAGGACAGCTAGGTC
ATGAAAAATCCAGAAAGAAACCAGAGCAGGTTGTTGCCCTGGATGCCCAAAATATTGTAGCTGTTTCATGTGGAGAAGCTCATACGTTAG
CGCTAAATGACAAAGGCCAGGTGTATGCTTGGGGTCTCGATTCTGATGGACAGCTTGGCCTGGTAGGATCAGAGGAATGCATCAGAGTAC
CCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCAAGTGAAG
TCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAGTCTTTGC
TTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGACGCAACA
AGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTTTATATTT
GTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAAC
TACCTTTGCCTTCTTCACCAAAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAG
ACTCCAGAACTAAATCCTTATGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCG
GCTTTCGGTCAGTATTTGGTACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTC
AAAATGTATTTTCAACAGAGCATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTA
AAGGCCTTAAAAATAAGGCTTCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCAC
TTTAAAGCTTCACAGTTCTGAAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAA
GATTTCAACTATATTTATTTGCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTT

>36185_36185_5_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000395198_RUFY2_chr10_70105668_ENST00000265865_length(amino acids)=306AA_BP=244
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFC

--------------------------------------------------------------
>36185_36185_6_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000412272_RUFY2_chr10_70105668_ENST00000265865_length(transcript)=1792nt_BP=1025nt
AGTCTCTTCCCCAACTCTCCCCACCCCTGGTGCTCTCCGCCCCGCTTGCCTCCCGTTCTTCCCCGCCCGCTCCATCCGGGTCGCTGACGG
CTGTCTCTGGACTGGACAGCAGTGGCGTCCGCTTTTCTCTAAGGAACCCGATAAGAACTCCATTTTCTGTTGATGTGGAGACATAGGGTA
CCTCCAACTTTCCGGGGTTTCAGAAGAGAATTTTTTATTGAAACTGGAAGACCAAAATAATTACAAGCATGTTGTGCTGGGGAAATGCAT
CCTTTGGGCAGCTAGGTTTGGGTGGAATTGATGAAGAAATTGTACTAGAGCCCAGAAAAAGTGACTTCTTTATAAATAAAAGGGTCCGAG
ATGTAGGATGTGGACTCAGACATACTGTGTTTGTTCTGGATGATGGAACAGTGTACACATGTGGATGTAATGATCTAGGACAGCTAGGTC
ATGAAAAATCCAGAAAGAAACCAGAGCAGGTTGTTGCCCTGGATGCCCAAAATATTGTAGCTGTTTCATGTGGAGAAGCTCATACGTTAG
CGCTAAATGACAAAGGCCAGGTGTATGCTTGGGGTCTCGATTCTGATGGACAGCTTGGCCTGGTAGGATCAGAGGAATGCATCAGAGTAC
CCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCAAGTGAAG
TCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAGTCTTTGC
TTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGACGCAACA
AGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTTTATATTT
GTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAAC
TACCTTTGCCTTCTTCACCAAAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAG
ACTCCAGAACTAAATCCTTATGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCG
GCTTTCGGTCAGTATTTGGTACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTC
AAAATGTATTTTCAACAGAGCATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTA
AAGGCCTTAAAAATAAGGCTTCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCAC
TTTAAAGCTTCACAGTTCTGAAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAA
GATTTCAACTATATTTATTTGCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTT

>36185_36185_6_HERC4-RUFY2_HERC4_chr10_69792534_ENST00000412272_RUFY2_chr10_70105668_ENST00000265865_length(amino acids)=306AA_BP=244
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFC

--------------------------------------------------------------
>36185_36185_7_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000277817_RUFY2_chr10_70105668_ENST00000388768_length(transcript)=3345nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGAC
AACGAACTACCTTTGCCTTCTTCACCAAAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTG
CCCTGAGACTCCAGAACTAAATCCTTATGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCC
TTAAGCGGCTTTCGGTCAGTATTTGGTACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATT
GTTTTTCAAAATGTATTTTCAACAGAGCATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTA
TCTTGTAAAGGCCTTAAAAATAAGGCTTCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTT
AATGCACTTTAAAGCTTCACAGTTCTGAAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATC
TTTGTAAGATTTCAACTATATTTATTTGCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTAC
AAAATTTCCTCTTGGTCTCTTTAAAAATCAGTTATTGTCGTGCTTGCTGAAGATTTTCAGCTACAGTGGATTAAATTAAAGGGGGCATTA
TTTGGCCTCGGCCTCTACTTTTTTCCTTTTAATCTTGAAAGGAAGTTACATATAACCATCTTTCTTTTCCTGATTTATAAATCTTCCCAT
ATGCTGTTTCATTAAATTGCTGTTTTTTTAAGGGGTGACTCAGACCCCAATTCAAAGATGAAAACACAAATCCTTCCCCAGAAAAAAAAG
TATGTAATAGTAGGGGATGTTACAGGCTCCTTATAAAGGTCCTCTCCTCTAAGCATTAAAAGTGAGAAAAAAATCAGGACTTTGCTTTGG
TAATGTATTAGAGTTCAGTTCAAAAAATTTTGTATTAACATTTTCATTGGAGTAAATTTTAGGAAGTATCACATTGTAGTGGCCTACCTG
TATACATCCACAGTAAAATTTCACCATGTCCATTGAGCACCTCTATGCCAAGGGTGTTGAGATGATGAAATATACACTTGACCTATTTCT
TTTTTTTTCGAGATGGAGTTTCACTCTTGTTGCCTAGGCTGGAGTGCAATGGCACGATCTCCACCTCCTGGGTTCAAGCAATTCTCCTGC
CTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGAGCCACAGCACCTGGCCAGTACACTTGACCTATTTCAAGCTGACTCAATGAACACT
AATCCAAGTTATATTGCTTATGGCATACTAAGAATTTAACTTGTATAAATTACCTCTGAATAGTTACATAAACACTATCACCATTCAGTA
TCCTATTTTTTACATTAATTTTTAACCATGCACTTTAAGTTTGTGAGCCTATAAAAAATACATAGAAAATTTATGGATTAAGAGCATTAT
ATTTAGTGGTTAATCCTAGGTACCTCCCTGCCTACAAAGGAGTTCTTATTAATACTGCAGGATCTTTTCTTCATGAATATATGCTTCCAT
GAAATTTAAATTTTTCTGAATAGCCTAAGTATGAAATGAATATTTTACTTGAAGATCTATTTTTTCCAAAACCCGTAAATTTCCAGTCAG
CTTTTGAGGTGTCAGATGTGACACAGATTTCTAGATGGTCTTTCTTGAATACTGACAGAAATGTCCTCAAGAGAGGATTATATTCTTGAA
CCATTTTGTATTGATAGGTGGGATGGGCTAACATTTTTATGATTACTGAATAAACAAAAAATGAAATTTTCAAATATGCTTTTTTATTAC
TGTGCTTAGAACAAATTTTAAAATGTGACTTAAGTTGCTTAAATTCCAAGGCTAATTTCATTCAACAAACCATGATTTTGTCATCCTTTA
AGTAAGTTTCTCACTTTTCAAAACTCATGTATCAACACTGACTGACTTGCTTTTTTTTTTTTTTTTTTTTTTTTTAGGCAGCTTTTATGA
CAGCAACTTGCTCCATGTAGTTTTGGCTTATTTAAAAACTATACTAACTTTGGATTTTTCTGTTACAAGACTTTTAACAATCTGTATTTC
GTGATTGTGAACTCGTATTCATTTTACTTTTCAAAAACAGACTTAACATACCATTCCCTCACCTAGCAGTACTACCACAATAATGCTATC
ATGGTGCCAGGGAATTACAATTGTAATTCTTCTAACCTATAATGTTTAAAAAATAAAATGTGAATTTTATGAACTAAATAAATATTTGGA

>36185_36185_7_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000277817_RUFY2_chr10_70105668_ENST00000388768_length(amino acids)=196AA_BP=134
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFCNACSDNELPLPSSPKPVRVC

--------------------------------------------------------------
>36185_36185_8_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000373700_RUFY2_chr10_70105668_ENST00000265865_length(transcript)=1857nt_BP=1090nt
ACTTCCGGCCAGCCCCTCCCCCGCCTCCCTCGCGTGGCCACCTCCCCCTCTGCCTTCTCCTACCCAGTCTCTTCCCCAACTCTCCCCACC
CCTGGTGCTCTCCGCCCCGCTTGCCTCCCGTTCTTCCCCGCCCGCTCCATCCGGGTCGCTGACGGCTGTCTCTGGACTGGACAGCAGTGG
CGTCCGCTTTTCTCTAAGGAACCCGATAAGAACTCCATTTTCTGTTGATGTGGAGACATAGGGTACCTCCAACTTTCCGGGGTTTCAGAA
GAGAATTTTTTATTGAAACTGGAAGACCAAAATAATTACAAGCATGTTGTGCTGGGGAAATGCATCCTTTGGGCAGCTAGGTTTGGGTGG
AATTGATGAAGAAATTGTACTAGAGCCCAGAAAAAGTGACTTCTTTATAAATAAAAGGGTCCGAGATGTAGGATGTGGACTCAGACATAC
TGTGTTTGTTCTGGATGATGGAACAGTGTACACATGTGGATGTAATGATCTAGGACAGCTAGGTCATGAAAAATCCAGAAAGAAACCAGA
GCAGGTTGTTGCCCTGGATGCCCAAAATATTGTAGCTGTTTCATGTGGAGAAGCTCATACGTTAGCGCTAAATGACAAAGGCCAGGTGTA
TGCTTGGGGTCTCGATTCTGATGGACAGCTTGGCCTGGTAGGATCAGAGGAATGCATCAGAGTACCCAGAAATATTAAAAGTTTGTCAGA
TATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCAAGTGAAGTCTTCTGTTGGGGACAGAATAAATA
TGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAGTCTTTGCTTGGAATCCCTTTCATGCAAGTTGC
AGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGACGCAACAAGTTTGGTCAGCTAGGTCTTAATGA
TGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTTTATATTTGTTGTGGAGAAGATCATACTGCTGC
TCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAACTACCTTTGCCTTCTTCACCAAAACC
AGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAGACTCCAGAACTAAATCCTTATGTAT
GAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCGGCTTTCGGTCAGTATTTGGTACCAG
TTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTCAAAATGTATTTTCAACAGAGCATGC
TTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTAAAGGCCTTAAAAATAAGGCTTCAGA
TTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCACTTTAAAGCTTCACAGTTCTGAAACT
GGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAAGATTTCAACTATATTTATTTGCCCT
TTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTTCCTCTTGGTCTCTTTAAAAATCAGT

>36185_36185_8_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000373700_RUFY2_chr10_70105668_ENST00000265865_length(amino acids)=306AA_BP=244
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFC

--------------------------------------------------------------
>36185_36185_9_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000395198_RUFY2_chr10_70105668_ENST00000265865_length(transcript)=1792nt_BP=1025nt
AGTCTCTTCCCCAACTCTCCCCACCCCTGGTGCTCTCCGCCCCGCTTGCCTCCCGTTCTTCCCCGCCCGCTCCATCCGGGTCGCTGACGG
CTGTCTCTGGACTGGACAGCAGTGGCGTCCGCTTTTCTCTAAGGAACCCGATAAGAACTCCATTTTCTGTTGATGTGGAGACATAGGGTA
CCTCCAACTTTCCGGGGTTTCAGAAGAGAATTTTTTATTGAAACTGGAAGACCAAAATAATTACAAGCATGTTGTGCTGGGGAAATGCAT
CCTTTGGGCAGCTAGGTTTGGGTGGAATTGATGAAGAAATTGTACTAGAGCCCAGAAAAAGTGACTTCTTTATAAATAAAAGGGTCCGAG
ATGTAGGATGTGGACTCAGACATACTGTGTTTGTTCTGGATGATGGAACAGTGTACACATGTGGATGTAATGATCTAGGACAGCTAGGTC
ATGAAAAATCCAGAAAGAAACCAGAGCAGGTTGTTGCCCTGGATGCCCAAAATATTGTAGCTGTTTCATGTGGAGAAGCTCATACGTTAG
CGCTAAATGACAAAGGCCAGGTGTATGCTTGGGGTCTCGATTCTGATGGACAGCTTGGCCTGGTAGGATCAGAGGAATGCATCAGAGTAC
CCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCAAGTGAAG
TCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAGTCTTTGC
TTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGACGCAACA
AGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTTTATATTT
GTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAAC
TACCTTTGCCTTCTTCACCAAAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAG
ACTCCAGAACTAAATCCTTATGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCG
GCTTTCGGTCAGTATTTGGTACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTC
AAAATGTATTTTCAACAGAGCATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTA
AAGGCCTTAAAAATAAGGCTTCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCAC
TTTAAAGCTTCACAGTTCTGAAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAA
GATTTCAACTATATTTATTTGCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTT

>36185_36185_9_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000395198_RUFY2_chr10_70105668_ENST00000265865_length(amino acids)=306AA_BP=244
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFC

--------------------------------------------------------------
>36185_36185_10_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000412272_RUFY2_chr10_70105668_ENST00000265865_length(transcript)=1792nt_BP=1025nt
AGTCTCTTCCCCAACTCTCCCCACCCCTGGTGCTCTCCGCCCCGCTTGCCTCCCGTTCTTCCCCGCCCGCTCCATCCGGGTCGCTGACGG
CTGTCTCTGGACTGGACAGCAGTGGCGTCCGCTTTTCTCTAAGGAACCCGATAAGAACTCCATTTTCTGTTGATGTGGAGACATAGGGTA
CCTCCAACTTTCCGGGGTTTCAGAAGAGAATTTTTTATTGAAACTGGAAGACCAAAATAATTACAAGCATGTTGTGCTGGGGAAATGCAT
CCTTTGGGCAGCTAGGTTTGGGTGGAATTGATGAAGAAATTGTACTAGAGCCCAGAAAAAGTGACTTCTTTATAAATAAAAGGGTCCGAG
ATGTAGGATGTGGACTCAGACATACTGTGTTTGTTCTGGATGATGGAACAGTGTACACATGTGGATGTAATGATCTAGGACAGCTAGGTC
ATGAAAAATCCAGAAAGAAACCAGAGCAGGTTGTTGCCCTGGATGCCCAAAATATTGTAGCTGTTTCATGTGGAGAAGCTCATACGTTAG
CGCTAAATGACAAAGGCCAGGTGTATGCTTGGGGTCTCGATTCTGATGGACAGCTTGGCCTGGTAGGATCAGAGGAATGCATCAGAGTAC
CCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCAAGTGAAG
TCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAGTCTTTGC
TTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGACGCAACA
AGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTTTATATTT
GTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGCACCACTGTAGAAATTGTGGGGAAATTTTCTGTAATGCCTGCTCTGACAACGAAC
TACCTTTGCCTTCTTCACCAAAACCAGTACGGGTTTGTGATTCCTGTCATGCACTGCTCATTCAGAGATGCTCATCTAACTTGCCCTGAG
ACTCCAGAACTAAATCCTTATGTATGAAATTACCTACAATGAATGTTATGATGTTGTATACAAAGGTAACCAGACAGCTCTCCTTAAGCG
GCTTTCGGTCAGTATTTGGTACCAGTTTATCTTCTACATATTCAGCTCATGGAAATTACAAGTTATATATTTCCTTCCCCATTGTTTTTC
AAAATGTATTTTCAACAGAGCATGCTTAAAAATCATGTAACTCATTAAAAGGCCAGAGAGCAGAGCTAACACAACTTGCCTTATCTTGTA
AAGGCCTTAAAAATAAGGCTTCAGATTGTTTTTTTCTTCTGAATTCTGTCAATTTGGTATTTGATGGTGCCTGCAGTTCTCTTAATGCAC
TTTAAAGCTTCACAGTTCTGAAACTGGAAACGCATAAAACTTTTAAAATTATTAATATTCTAATTCAACAGATTTTCATTATCTTTGTAA
GATTTCAACTATATTTATTTGCCCTTTCTTCTCCCCCTCTCCCTTTGCCTCTTGCATTAGACAGGGCCAATATTTTGTCCTACAAAATTT

>36185_36185_10_HERC4-RUFY2_HERC4_chr10_69792535_ENST00000412272_RUFY2_chr10_70105668_ENST00000265865_length(amino acids)=306AA_BP=244
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKHHCRNCGEIFC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HERC4-RUFY2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HERC4-RUFY2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HERC4-RUFY2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource