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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HEY1-NCOA2 (FusionGDB2 ID:36228) |
Fusion Gene Summary for HEY1-NCOA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HEY1-NCOA2 | Fusion gene ID: 36228 | Hgene | Tgene | Gene symbol | HEY1 | NCOA2 | Gene ID | 23462 | 10499 |
| Gene name | hes related family bHLH transcription factor with YRPW motif 1 | nuclear receptor coactivator 2 | |
| Synonyms | BHLHb31|CHF2|HERP2|HESR1|HRT-1|NERP2|OAF1|hHRT1 | GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75 | |
| Cytomap | 8q21.13 | 8q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hairy/enhancer-of-split related with YRPW motif protein 1HES-related repressor protein 1HES-related repressor protein 2basic helix-loop-helix protein OAF1cardiovascular helix-loop-helix factor 2class B basic helix-loop-helix protein 31hairy and enha | nuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2 | |
| Modification date | 20200324 | 20200313 | |
| UniProtAcc | . | Q15596 | |
| Ensembl transtripts involved in fusion gene | ENST00000337919, ENST00000354724, ENST00000435063, ENST00000523976, | ENST00000267974, ENST00000524223, ENST00000452400, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 19 X 24 X 6=2736 |
| # samples | 1 | 12 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/2736*10)=-4.51096191927738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HEY1 [Title/Abstract] AND NCOA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | |||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HEY1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16043483|21290414 |
| Hgene | HEY1 | GO:0007219 | Notch signaling pathway | 10964718|25985737 |
| Hgene | HEY1 | GO:0045746 | negative regulation of Notch signaling pathway | 18239137 |
| Hgene | HEY1 | GO:0045892 | negative regulation of transcription, DNA-templated | 15485867 |
| Hgene | HEY1 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 18239137 |
| Hgene | HEY1 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | 18239137 |
| Fusion gene breakpoints across HEY1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across NCOA2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| ChimerKB3 | . | . | HEY1 | chr8 | 80678885 | + | NCOA2 | chr8 | 71057083 | + |
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Fusion Gene ORF analysis for HEY1-NCOA2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000337919 | ENST00000267974 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| 5CDS-intron | ENST00000337919 | ENST00000524223 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| 5CDS-intron | ENST00000354724 | ENST00000267974 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| 5CDS-intron | ENST00000354724 | ENST00000524223 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| In-frame | ENST00000337919 | ENST00000452400 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| In-frame | ENST00000354724 | ENST00000452400 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| intron-3CDS | ENST00000435063 | ENST00000452400 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| intron-3CDS | ENST00000523976 | ENST00000452400 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| intron-intron | ENST00000435063 | ENST00000267974 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| intron-intron | ENST00000435063 | ENST00000524223 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| intron-intron | ENST00000523976 | ENST00000267974 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| intron-intron | ENST00000523976 | ENST00000524223 | HEY1 | chr8 | 80678885 | - | NCOA2 | chr8 | 71057083 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000354724 | HEY1 | chr8 | 80678885 | - | ENST00000452400 | NCOA2 | chr8 | 71057083 | - | 6191 | 531 | 155 | 2320 | 721 |
| ENST00000337919 | HEY1 | chr8 | 80678885 | - | ENST00000452400 | NCOA2 | chr8 | 71057083 | - | 6197 | 537 | 149 | 2326 | 725 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HEY1-NCOA2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HEY1-NCOA2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:/chr8:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | NCOA2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:9430642}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HEY1-NCOA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >36228_36228_1_HEY1-NCOA2_HEY1_chr8_80678885_ENST00000337919_NCOA2_chr8_71057083_ENST00000452400_length(transcript)=6197nt_BP=537nt ACTCCCCCGCCCTCCCCAGGGCCCTGGGAAGGGGCTCAGCGTGGGAAAGGATGGTTGAGTTTTAACCAGAGGCAAAGCGTGAGCGGGATC AGTGTGTGCGGAACGCAAGCAGCCGAGAGCGGAGAGGCGCCGCTGTAGTTAACTCCTCCCTGCCCGCCGCGCCGACCCTCCCCAGGAACC CCCAGGGAGCCAGCATGAAGCGAGCTCACCCCGAGTACAGCTCCTCGGACAGCGAGCTGGACGAGACCATCGAGGTGGAGAAGGAGAGTG CGGACGAGAATGGAAACTTGAGTTCGGCTCTAGGTTCCATGTCCCCAACTACATCTTCCCAGATTTTGGCCAGAAAAAGACGGAGAGGAA TAATTGAGAAGCGCCGACGAGACCGGATCAATAACAGTTTGTCTGAGCTGAGAAGGCTGGTACCCAGTGCTTTTGAGAAGCAGGTAATGG AGCAAGGATCTGCTAAGCTAGAAAAAGCCGAGATCCTGCAGATGACCGTGGATCACCTGAAAATGCTGCATACGGCAGGAGGGAAAGCTT TTAATAACCCACGACCAGGGCAACTGGGCAGGTTATTGCCAAACCAGAATTTACCACTTGACATCACATTGCAAAGCCCAACTGGTGCTG GACCTTTCCCACCAATCAGAAACAGTAGTCCCTACTCAGTGATACCTCAGCCAGGAATGATGGGTAATCAAGGGATGATAGGAAACCAAG GAAATTTAGGGAACAGTAGCACAGGAATGATTGGTAACAGTGCTTCTCGGCCTACTATGCCATCTGGAGAATGGGCACCGCAGAGTTCGG CTGTGAGAGTCACCTGTGCTGCTACCACCAGTGCCATGAACCGGCCAGTCCAAGGAGGTATGATTCGGAACCCAGCAGCCAGCATCCCCA TGAGGCCCAGCAGCCAGCCTGGCCAAAGACAGACGCTTCAGTCTCAGGTCATGAATATAGGGCCATCTGAATTAGAGATGAACATGGGGG GACCTCAGTATAGCCAACAACAAGCTCCTCCAAATCAGACTGCCCCATGGCCTGAAAGCATCCTGCCTATAGACCAGGCGTCTTTTGCCA GCCAAAACAGGCAGCCATTTGGCAGTTCTCCAGATGACTTGCTATGTCCACATCCTGCAGCTGAGTCTCCGAGTGATGAGGGAGCTCTCC TGGACCAGCTGTATCTGGCCTTGCGGAATTTTGATGGCCTGGAGGAGATTGATAGAGCCTTAGGAATACCCGAACTGGTCAGCCAGAGCC AAGCAGTAGATCCAGAACAGTTCTCAAGTCAGGATTCCAACATCATGCTGGAGCAGAAGGCGCCCGTTTTCCCACAGCAGTATGCATCTC AGGCACAAATGGCCCAGGGTAGCTATTCTCCCATGCAAGATCCAAACTTTCACACCATGGGACAGCGGCCTAGTTATGCCACACTCCGTA TGCAGCCCAGACCGGGCCTCAGGCCCACGGGCCTAGTGCAGAACCAGCCAAATCAACTAAGACTTCAACTTCAGCATCGCCTCCAAGCAC AGCAGAATCGCCAGCCACTTATGAATCAAATCAGCAATGTTTCCAATGTGAACTTGACTCTGAGGCCTGGAGTACCAACACAGGCACCTA TTAATGCACAGATGCTGGCCCAGAGACAGAGGGAAATCCTGAACCAGCATCTTCGACAGAGACAAATGCATCAGCAACAGCAAGTTCAGC AACGAACTTTGATGATGAGAGGACAAGGGTTGAATATGACACCAAGCATGGTGGCTCCTAGTGGTATGCCAGCAACTATGAGCAACCCTC GGATTCCCCAGGCAAATGCACAGCAGTTTCCATTTCCTCCAAACTACGGAATAAGTCAGCAACCTGATCCAGGCTTTACTGGGGCTACGA CTCCCCAGAGCCCACTTATGTCACCCCGAATGGCACATACACAGAGTCCCATGATGCAACAGTCTCAGGCCAACCCAGCCTATCAGGCCC CCTCCGACATAAATGGATGGGCGCAGGGGAACATGGGCGGAAACAGCATGTTTTCCCAGCAGTCCCCACCACACTTTGGGCAGCAAGCAA ACACCAGCATGTACAGTAACAACATGAACATCAATGTGTCCATGGCGACCAACACAGGTGGCATGAGCAGCATGAACCAGATGACAGGAC AGATCAGCATGACCTCAGTGACCTCCGTGCCTACGTCAGGGCTGTCCTCCATGGGTCCCGAGCAGGTTAATGATCCTGCTCTGAGGGGAG GCAACCTGTTCCCAAACCAGCTGCCTGGAATGGATATGATTAAGCAGGAGGGAGACACAACACGGAAATATTGCTGACACTGCTGAAGCC AGTTGCTTCTTCAGCTGACCGGGCTCACTTGCTCAAAACACTTCCAGTCTGGAGAGCTGTGTCTATTTGTTTCAACCCAACTGACCTGCC AGCCGGTTCTGCTAGAGCAGACAGGCCTGGCCCTGGTTCCCAGGGTGGCGTCCACTCGGCTGTGGCAGGAGGAGCTGCCTCTTCTCTTGA CAGTCTGAAGCTCGCATCCAGACAGTCGCTCAGTCTGTTCACTGCATTCACCTTAGTGCAACTTAGATCTCTCCTGCAAAAGTAAATGTT GACAGGCAAATTTCATACCCATGTCAGATTGAATGTATTTAAATGTATGTATTTAAGGAGAACCATGCTCTTGTTCTGTTCCTGTTCGGT TCCAGACACTGGTTTCTTGCTTTGTTTTCCCTGGCTAACAGTCTAGTGCAAAAGATTAAGATTTTATCTGGGGGAAAGAAAAGAATTTTT TAAAAAATTAAACTAAAGATGTTTTAAGCTAAAGCCTGAATTTGGGATGGAAGCAGGACAGACACCGTGGACAGCGCTGTATTTACAGAC ACACCCAGTGCGTGAAGACCAACAAAGTCACAGTCGTATCTCTAGAAAGCTCTAAAGACCATGTTGGAAAGAGTCTCCAGTTACTGAACA GATGAAAAGGAGCCTGTGAGAGGGCTGTTAACATTAGCAAATATTTTTTCCTTGTTTTTTCTTTGTTAAAACCAAACTGGTTCACCTGAA TCATGAATTGAGAAGAAATAATTTTCATTTCTAAATTAAGTCCCTTTTAGTTTGATCAGACAGCTTGAATCAGCATCTCTTCTTCCCTGT CAGCCTGACTCTTCCCTTCCCCTCTCTCATTCCCCATACTCCCTATTTTCATTCCTTTTTTAAAAAATAATATAAGCTACAGAAACCAGG TAAGCCCTTTATTTCCTTAAATGTTTTGCCAGCCACTTACCAATTGCTAAGTATTGAATTTCAGAAAAAAAAAATGCATTTACTGGCAAG GAGAAGAGCAAAGTTAAGGCTTGATACCAATCGAGCTAAGGATACCTGCTTTGGAAGCATGTTTATTCTGTTCCCCAGCAACTCTGGCCT CCAAAATGGGAGAAAACGCCAGTGTGTTTAAATTGATAGCAGATATCACGACAGATTTAACCTCTGCCATGTGTTTTTTATTTTGTTTTT TAGCAGTGCTGACTAAGCCGAAGTTTTGTAAGGTACATAAAATCCAATTTATATGTAAACAAGCAATAATTTAAGTTGAGAACTTATGTG TTTTAATTGTATAATTTTTGTGAGGTATACATATTGTGGAATTGACTCAAAAATGAGGTACTTCAGTATTAAATTAGATATCTTCATAGC AATGTCTCCTAAAGGTGTTTTGTAAAGGATATCAATGCCTTGATTAGACCTAATTTGTAGACTTAAGACTTTTTATTTTCTAAACCTTGT GATTCTGCTTATAAGTCATTTATCTAATCTATATGATATGCAGCCGCTGTAGGAACCAATTCTTGATTTTTATATGTTTATATTCTTTCT TAATGAACCTTAGAAAGACTACATGTTACTAAGCAGGCCACTTTTATGGTTGTTTTTCTTGCCCACTCTGGTAGGGGAAAAATCTTTTAT TAATAGGTGTCAGTTTCAGACAACTCCAATACCAAGAAACTGATGACCTTTTTTGAGCTATTTCTCCTTAACCCCTAATACCTTTCTTAC CTAAATTTCAGAATGATATCTTTTTGATGTCTAAAAAGCAAAGCATTTTATAATATCTCATTAGCCAGGCTTTTTAGGAACAGAGAAGTT TTTCCTTGAAATTTGATTGTTTGTTTATTTGTGGCAGGGTGAAAAATGTACAAACTACCCCTATTTATACTTATATCTCTCTCTATATGT ACGCATTATGGAAATATAGGAAGAGATATAGCCCAAAGATAGATGGTAAGTAGACAGTCTGAAAATGTTGCTCCATACTAAAGAACCTTT CTGGAAATTTGCATTTCGCTACTTTTTTCCACTTGAGAGGGGTCTCAATACAGGGAGGTGGCCAAGGAACAACACTTCTCAGTGGCCACC AGTTCATATATCCCCTCAAAAGGCTCTACTTTTCTCCACCAAACCATTGGGTTGCCCAACTGTGATGGAAAAAACAAGCAGATGTTGGCC CAGAACTCCAGGACCTCCCCGTGGGCTGAGGCTCATGTGGCATACAATTCAGTGTGACCAGTTTTAATGTTCAGAAATATGTGAATTAGA ATGACTTTTAACTTCACACAGCACAAAAGAGAAATGGAGTTTAAACTGGATTTGTTTTGTTTTGAGTTTCAAGTCCCTTTTCACTACAAC ACCGTCCAAAACTATCTACCTATCTCTTCTTTTTTATCCATCTGCCCGCTGTATTTTAATGTCAATCCTAATTCAGACAAATCCGCAACT TCATGATACTGGTAATTTATAATAATTCGTGATCATTGCTGTTTTGAAGGAAAAGAGATGATAAATTCTCTTACGGTTTCAATCAGGTAA TGGATTTTGTTTTACATCTAGTTAGGAGAAGAAAAGTAAGTGAAGGAATCCTCTGATCATATTGATCACTATAGAAGCAAAAGCCAAATC AGTTCCCTTCATTATCAGTATTTCTCATGCTGTACACAATAAATTTGTTAGACTGAGTACTTGGTTTTTGTTTAATAGAACAAATAATCA GTGTTTCACTTATATTACTAAATGTGAAAAACATAATGTGAAAAGTATACATACATTAACTTGGTTGTAAAACTCATTTTAAGTGTTCAT GTAATGTGGTAAGTTTAAAAAGTGAAGTGAGCTGTTTTACTACAATGAATTCGTTTGACTCAAAGATTAAAATGCCCCTCCCCCTATGTG TATCTCTTATGGCCTGTAATAATTGAAAGCAATGTTTTTGCAGTTTATATAATGCAATTTTTAATCTGTGTTCAAAAATGGAGTTCATAT GGGCTTAACACATGAAATGGGTGGCACAGATCCACTTGCAGAACCCAAAGATACACAATCAGTTTTGAAATGCAACTTAAGCCATTAATT GTTGGTGTGAATTTAAAATTTTCTAGTGTTTGTATGGTGGTATGCTGCCTAAGAGCAAAGCATCCTCTGCACAAAAGAAAATTACTGTAG TGGCTTCGATTTTAATTAGAATTTTCTCCCTGGTGTTTCTTTATAGACTAAAGCAAAATCTTTTAAGTTTCTTACTACAGGTAAAAGCTA TGTGCAAGAACCTCAAAATGCTAAAATCTAGCATAATGCCTTAGATCTGTTTTTAAGTCTTGTATATTCCTACATAGCTGTCCGATGTAT TATATTTGTATAGTGAATTGTGTACAATTTTTGAATAAGTGCATCATCACTTAACCTTTATGTTGTTTGAATAGTGATGATGATACATTT CTTCAGACATTTAACTGTCATTTTTTTCCTTTGTCATTTGTGAGTTTTATTTGTACAGTTCCTCATGAAGTTGCATCTGAGATGTGTGTA TATGAAAAGATTATACAAGGGTAAAATTAAGCAATATATTAACTATGGTTCTTCAGGAGAAAGCTTACAGTGTTTCAGGTTGTGATTTAT TTTCAAAATGGAGTTGACTCTGAACATCACTTTGTTCACCTGCATTGATGTTTGTATTTCTAGTGTGAGCAGTTTATGCAAAGGTAGATA TATTCAGAGAAATTTTAAATACATTTATGCAAGTTAATATTGCTTTGCTGATGCTATTTGCTTATTTGATGTTAAATAATGCTATTGTAA >36228_36228_1_HEY1-NCOA2_HEY1_chr8_80678885_ENST00000337919_NCOA2_chr8_71057083_ENST00000452400_length(amino acids)=725AA_BP=129 MPAAPTLPRNPQGASMKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRL VPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKAFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGM MGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNI GPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRA LGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQL RLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAP SGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQ QSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDT -------------------------------------------------------------- >36228_36228_2_HEY1-NCOA2_HEY1_chr8_80678885_ENST00000354724_NCOA2_chr8_71057083_ENST00000452400_length(transcript)=6191nt_BP=531nt TTCCCCACTCCCCCGCCCTCCCCAGGGCCCTGGGAAGGGGCTCAGCGTGGGAAAGGATGGTTGAGTTTTAACCAGAGGCAAAGCGTGAGC GGGATCAGTGTGTGCGGAACGCAAGCAGCCGAGAGCGGAGAGGCGCCGCTGTAGTTAACTCCTCCCTGCCCGCCGCGCCGACCCTCCCCA GGAACCCCCAGGGAGCCAGCATGAAGCGAGCTCACCCCGAGTACAGCTCCTCGGACAGCGAGCTGGACGAGACCATCGAGGTGGAGAAGG AGAGTGCGGACGAGAATGGAAACTTGAGTTCGGCTCTAGGTTCCATGTCCCCAACTACATCTTCCCAGATTTTGGCCAGAAAAAGACGGA GAGGAATAATTGAGAAGCGCCGACGAGACCGGATCAATAACAGTTTGTCTGAGCTGAGAAGGCTGGTACCCAGTGCTTTTGAGAAGCAGG GATCTGCTAAGCTAGAAAAAGCCGAGATCCTGCAGATGACCGTGGATCACCTGAAAATGCTGCATACGGCAGGAGGGAAAGCTTTTAATA ACCCACGACCAGGGCAACTGGGCAGGTTATTGCCAAACCAGAATTTACCACTTGACATCACATTGCAAAGCCCAACTGGTGCTGGACCTT TCCCACCAATCAGAAACAGTAGTCCCTACTCAGTGATACCTCAGCCAGGAATGATGGGTAATCAAGGGATGATAGGAAACCAAGGAAATT TAGGGAACAGTAGCACAGGAATGATTGGTAACAGTGCTTCTCGGCCTACTATGCCATCTGGAGAATGGGCACCGCAGAGTTCGGCTGTGA GAGTCACCTGTGCTGCTACCACCAGTGCCATGAACCGGCCAGTCCAAGGAGGTATGATTCGGAACCCAGCAGCCAGCATCCCCATGAGGC CCAGCAGCCAGCCTGGCCAAAGACAGACGCTTCAGTCTCAGGTCATGAATATAGGGCCATCTGAATTAGAGATGAACATGGGGGGACCTC AGTATAGCCAACAACAAGCTCCTCCAAATCAGACTGCCCCATGGCCTGAAAGCATCCTGCCTATAGACCAGGCGTCTTTTGCCAGCCAAA ACAGGCAGCCATTTGGCAGTTCTCCAGATGACTTGCTATGTCCACATCCTGCAGCTGAGTCTCCGAGTGATGAGGGAGCTCTCCTGGACC AGCTGTATCTGGCCTTGCGGAATTTTGATGGCCTGGAGGAGATTGATAGAGCCTTAGGAATACCCGAACTGGTCAGCCAGAGCCAAGCAG TAGATCCAGAACAGTTCTCAAGTCAGGATTCCAACATCATGCTGGAGCAGAAGGCGCCCGTTTTCCCACAGCAGTATGCATCTCAGGCAC AAATGGCCCAGGGTAGCTATTCTCCCATGCAAGATCCAAACTTTCACACCATGGGACAGCGGCCTAGTTATGCCACACTCCGTATGCAGC CCAGACCGGGCCTCAGGCCCACGGGCCTAGTGCAGAACCAGCCAAATCAACTAAGACTTCAACTTCAGCATCGCCTCCAAGCACAGCAGA ATCGCCAGCCACTTATGAATCAAATCAGCAATGTTTCCAATGTGAACTTGACTCTGAGGCCTGGAGTACCAACACAGGCACCTATTAATG CACAGATGCTGGCCCAGAGACAGAGGGAAATCCTGAACCAGCATCTTCGACAGAGACAAATGCATCAGCAACAGCAAGTTCAGCAACGAA CTTTGATGATGAGAGGACAAGGGTTGAATATGACACCAAGCATGGTGGCTCCTAGTGGTATGCCAGCAACTATGAGCAACCCTCGGATTC CCCAGGCAAATGCACAGCAGTTTCCATTTCCTCCAAACTACGGAATAAGTCAGCAACCTGATCCAGGCTTTACTGGGGCTACGACTCCCC AGAGCCCACTTATGTCACCCCGAATGGCACATACACAGAGTCCCATGATGCAACAGTCTCAGGCCAACCCAGCCTATCAGGCCCCCTCCG ACATAAATGGATGGGCGCAGGGGAACATGGGCGGAAACAGCATGTTTTCCCAGCAGTCCCCACCACACTTTGGGCAGCAAGCAAACACCA GCATGTACAGTAACAACATGAACATCAATGTGTCCATGGCGACCAACACAGGTGGCATGAGCAGCATGAACCAGATGACAGGACAGATCA GCATGACCTCAGTGACCTCCGTGCCTACGTCAGGGCTGTCCTCCATGGGTCCCGAGCAGGTTAATGATCCTGCTCTGAGGGGAGGCAACC TGTTCCCAAACCAGCTGCCTGGAATGGATATGATTAAGCAGGAGGGAGACACAACACGGAAATATTGCTGACACTGCTGAAGCCAGTTGC TTCTTCAGCTGACCGGGCTCACTTGCTCAAAACACTTCCAGTCTGGAGAGCTGTGTCTATTTGTTTCAACCCAACTGACCTGCCAGCCGG TTCTGCTAGAGCAGACAGGCCTGGCCCTGGTTCCCAGGGTGGCGTCCACTCGGCTGTGGCAGGAGGAGCTGCCTCTTCTCTTGACAGTCT GAAGCTCGCATCCAGACAGTCGCTCAGTCTGTTCACTGCATTCACCTTAGTGCAACTTAGATCTCTCCTGCAAAAGTAAATGTTGACAGG CAAATTTCATACCCATGTCAGATTGAATGTATTTAAATGTATGTATTTAAGGAGAACCATGCTCTTGTTCTGTTCCTGTTCGGTTCCAGA CACTGGTTTCTTGCTTTGTTTTCCCTGGCTAACAGTCTAGTGCAAAAGATTAAGATTTTATCTGGGGGAAAGAAAAGAATTTTTTAAAAA ATTAAACTAAAGATGTTTTAAGCTAAAGCCTGAATTTGGGATGGAAGCAGGACAGACACCGTGGACAGCGCTGTATTTACAGACACACCC AGTGCGTGAAGACCAACAAAGTCACAGTCGTATCTCTAGAAAGCTCTAAAGACCATGTTGGAAAGAGTCTCCAGTTACTGAACAGATGAA AAGGAGCCTGTGAGAGGGCTGTTAACATTAGCAAATATTTTTTCCTTGTTTTTTCTTTGTTAAAACCAAACTGGTTCACCTGAATCATGA ATTGAGAAGAAATAATTTTCATTTCTAAATTAAGTCCCTTTTAGTTTGATCAGACAGCTTGAATCAGCATCTCTTCTTCCCTGTCAGCCT GACTCTTCCCTTCCCCTCTCTCATTCCCCATACTCCCTATTTTCATTCCTTTTTTAAAAAATAATATAAGCTACAGAAACCAGGTAAGCC CTTTATTTCCTTAAATGTTTTGCCAGCCACTTACCAATTGCTAAGTATTGAATTTCAGAAAAAAAAAATGCATTTACTGGCAAGGAGAAG AGCAAAGTTAAGGCTTGATACCAATCGAGCTAAGGATACCTGCTTTGGAAGCATGTTTATTCTGTTCCCCAGCAACTCTGGCCTCCAAAA TGGGAGAAAACGCCAGTGTGTTTAAATTGATAGCAGATATCACGACAGATTTAACCTCTGCCATGTGTTTTTTATTTTGTTTTTTAGCAG TGCTGACTAAGCCGAAGTTTTGTAAGGTACATAAAATCCAATTTATATGTAAACAAGCAATAATTTAAGTTGAGAACTTATGTGTTTTAA TTGTATAATTTTTGTGAGGTATACATATTGTGGAATTGACTCAAAAATGAGGTACTTCAGTATTAAATTAGATATCTTCATAGCAATGTC TCCTAAAGGTGTTTTGTAAAGGATATCAATGCCTTGATTAGACCTAATTTGTAGACTTAAGACTTTTTATTTTCTAAACCTTGTGATTCT GCTTATAAGTCATTTATCTAATCTATATGATATGCAGCCGCTGTAGGAACCAATTCTTGATTTTTATATGTTTATATTCTTTCTTAATGA ACCTTAGAAAGACTACATGTTACTAAGCAGGCCACTTTTATGGTTGTTTTTCTTGCCCACTCTGGTAGGGGAAAAATCTTTTATTAATAG GTGTCAGTTTCAGACAACTCCAATACCAAGAAACTGATGACCTTTTTTGAGCTATTTCTCCTTAACCCCTAATACCTTTCTTACCTAAAT TTCAGAATGATATCTTTTTGATGTCTAAAAAGCAAAGCATTTTATAATATCTCATTAGCCAGGCTTTTTAGGAACAGAGAAGTTTTTCCT TGAAATTTGATTGTTTGTTTATTTGTGGCAGGGTGAAAAATGTACAAACTACCCCTATTTATACTTATATCTCTCTCTATATGTACGCAT TATGGAAATATAGGAAGAGATATAGCCCAAAGATAGATGGTAAGTAGACAGTCTGAAAATGTTGCTCCATACTAAAGAACCTTTCTGGAA ATTTGCATTTCGCTACTTTTTTCCACTTGAGAGGGGTCTCAATACAGGGAGGTGGCCAAGGAACAACACTTCTCAGTGGCCACCAGTTCA TATATCCCCTCAAAAGGCTCTACTTTTCTCCACCAAACCATTGGGTTGCCCAACTGTGATGGAAAAAACAAGCAGATGTTGGCCCAGAAC TCCAGGACCTCCCCGTGGGCTGAGGCTCATGTGGCATACAATTCAGTGTGACCAGTTTTAATGTTCAGAAATATGTGAATTAGAATGACT TTTAACTTCACACAGCACAAAAGAGAAATGGAGTTTAAACTGGATTTGTTTTGTTTTGAGTTTCAAGTCCCTTTTCACTACAACACCGTC CAAAACTATCTACCTATCTCTTCTTTTTTATCCATCTGCCCGCTGTATTTTAATGTCAATCCTAATTCAGACAAATCCGCAACTTCATGA TACTGGTAATTTATAATAATTCGTGATCATTGCTGTTTTGAAGGAAAAGAGATGATAAATTCTCTTACGGTTTCAATCAGGTAATGGATT TTGTTTTACATCTAGTTAGGAGAAGAAAAGTAAGTGAAGGAATCCTCTGATCATATTGATCACTATAGAAGCAAAAGCCAAATCAGTTCC CTTCATTATCAGTATTTCTCATGCTGTACACAATAAATTTGTTAGACTGAGTACTTGGTTTTTGTTTAATAGAACAAATAATCAGTGTTT CACTTATATTACTAAATGTGAAAAACATAATGTGAAAAGTATACATACATTAACTTGGTTGTAAAACTCATTTTAAGTGTTCATGTAATG TGGTAAGTTTAAAAAGTGAAGTGAGCTGTTTTACTACAATGAATTCGTTTGACTCAAAGATTAAAATGCCCCTCCCCCTATGTGTATCTC TTATGGCCTGTAATAATTGAAAGCAATGTTTTTGCAGTTTATATAATGCAATTTTTAATCTGTGTTCAAAAATGGAGTTCATATGGGCTT AACACATGAAATGGGTGGCACAGATCCACTTGCAGAACCCAAAGATACACAATCAGTTTTGAAATGCAACTTAAGCCATTAATTGTTGGT GTGAATTTAAAATTTTCTAGTGTTTGTATGGTGGTATGCTGCCTAAGAGCAAAGCATCCTCTGCACAAAAGAAAATTACTGTAGTGGCTT CGATTTTAATTAGAATTTTCTCCCTGGTGTTTCTTTATAGACTAAAGCAAAATCTTTTAAGTTTCTTACTACAGGTAAAAGCTATGTGCA AGAACCTCAAAATGCTAAAATCTAGCATAATGCCTTAGATCTGTTTTTAAGTCTTGTATATTCCTACATAGCTGTCCGATGTATTATATT TGTATAGTGAATTGTGTACAATTTTTGAATAAGTGCATCATCACTTAACCTTTATGTTGTTTGAATAGTGATGATGATACATTTCTTCAG ACATTTAACTGTCATTTTTTTCCTTTGTCATTTGTGAGTTTTATTTGTACAGTTCCTCATGAAGTTGCATCTGAGATGTGTGTATATGAA AAGATTATACAAGGGTAAAATTAAGCAATATATTAACTATGGTTCTTCAGGAGAAAGCTTACAGTGTTTCAGGTTGTGATTTATTTTCAA AATGGAGTTGACTCTGAACATCACTTTGTTCACCTGCATTGATGTTTGTATTTCTAGTGTGAGCAGTTTATGCAAAGGTAGATATATTCA GAGAAATTTTAAATACATTTATGCAAGTTAATATTGCTTTGCTGATGCTATTTGCTTATTTGATGTTAAATAATGCTATTGTAAATAAAG >36228_36228_2_HEY1-NCOA2_HEY1_chr8_80678885_ENST00000354724_NCOA2_chr8_71057083_ENST00000452400_length(amino acids)=721AA_BP=125 MPAAPTLPRNPQGASMKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRL VPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKAFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQ GMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE LEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIP ELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQL QHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMP ATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPP HFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HEY1-NCOA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HEY1-NCOA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HEY1-NCOA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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