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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:HIF1A-SF3B1 (FusionGDB2 ID:36347)

Fusion Gene Summary for HIF1A-SF3B1

check button Fusion gene summary
Fusion gene informationFusion gene name: HIF1A-SF3B1
Fusion gene ID: 36347
HgeneTgene
Gene symbol

HIF1A

SF3B1

Gene ID

3091

23451

Gene namehypoxia inducible factor 1 subunit alphasplicing factor 3b subunit 1
SynonymsHIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78Hsh155|MDS|PRP10|PRPF10|SAP155|SF3b155
Cytomap

14q23.2

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionhypoxia-inducible factor 1-alphaARNT interacting proteinPAS domain-containing protein 8basic-helix-loop-helix-PAS protein MOP1class E basic helix-loop-helix protein 78hypoxia inducible factor 1 alpha subunithypoxia inducible factor 1, alpha subunit splicing factor 3B subunit 1pre-mRNA processing 10pre-mRNA splicing factor SF3b, 155 kDa subunitspliceosome-associated protein 155splicing factor 3b, subunit 1, 155kDa
Modification date2020032920200329
UniProtAcc

Q16665

.
Ensembl transtripts involved in fusion geneENST00000323441, ENST00000337138, 
ENST00000394997, ENST00000539097, 
ENST00000557538, ENST00000557206, 
ENST00000409915, ENST00000414963, 
ENST00000462613, ENST00000487698, 
ENST00000335508, 
Fusion gene scores* DoF score14 X 11 X 10=15406 X 8 X 4=192
# samples 249
** MAII scorelog2(24/1540*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HIF1A [Title/Abstract] AND SF3B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHIF1A(62203827)-SF3B1(198283312), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIF1A

GO:0001666

response to hypoxia

8756616|9887100|11782478|15261140|18419598

HgeneHIF1A

GO:0006355

regulation of transcription, DNA-templated

11782478|15261140

HgeneHIF1A

GO:0010468

regulation of gene expression

18419598

HgeneHIF1A

GO:0010573

vascular endothelial growth factor production

12958148

HgeneHIF1A

GO:0010575

positive regulation of vascular endothelial growth factor production

8756616

HgeneHIF1A

GO:0010628

positive regulation of gene expression

15459207|24244340

HgeneHIF1A

GO:0032364

oxygen homeostasis

16956324

HgeneHIF1A

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

8089148|8387214

HgeneHIF1A

GO:0045893

positive regulation of transcription, DNA-templated

8089148|9887100|25043030

HgeneHIF1A

GO:0045944

positive regulation of transcription by RNA polymerase II

11573933

HgeneHIF1A

GO:0046886

positive regulation of hormone biosynthetic process

1448077

HgeneHIF1A

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

22735262

HgeneHIF1A

GO:0071456

cellular response to hypoxia

11573933|19528298|20889502

HgeneHIF1A

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19782034

HgeneHIF1A

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

24899725

TgeneSF3B1

GO:0000398

mRNA splicing, via spliceosome

11252167|28781166|29360106


check buttonFusion gene breakpoints across HIF1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SF3B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315469HIF1Achr14

62203827

+SF3B1chr2

198283312

-


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Fusion Gene ORF analysis for HIF1A-SF3B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000323441ENST00000409915HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-3UTRENST00000337138ENST00000409915HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-3UTRENST00000394997ENST00000409915HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-3UTRENST00000539097ENST00000409915HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-3UTRENST00000557538ENST00000409915HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000323441ENST00000414963HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000323441ENST00000462613HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000323441ENST00000487698HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000337138ENST00000414963HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000337138ENST00000462613HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000337138ENST00000487698HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000394997ENST00000414963HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000394997ENST00000462613HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000394997ENST00000487698HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000539097ENST00000414963HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000539097ENST00000462613HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000539097ENST00000487698HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000557538ENST00000414963HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000557538ENST00000462613HIF1Achr14

62203827

+SF3B1chr2

198283312

-
5CDS-intronENST00000557538ENST00000487698HIF1Achr14

62203827

+SF3B1chr2

198283312

-
In-frameENST00000323441ENST00000335508HIF1Achr14

62203827

+SF3B1chr2

198283312

-
In-frameENST00000337138ENST00000335508HIF1Achr14

62203827

+SF3B1chr2

198283312

-
In-frameENST00000394997ENST00000335508HIF1Achr14

62203827

+SF3B1chr2

198283312

-
In-frameENST00000539097ENST00000335508HIF1Achr14

62203827

+SF3B1chr2

198283312

-
In-frameENST00000557538ENST00000335508HIF1Achr14

62203827

+SF3B1chr2

198283312

-
intron-3CDSENST00000557206ENST00000335508HIF1Achr14

62203827

+SF3B1chr2

198283312

-
intron-3UTRENST00000557206ENST00000409915HIF1Achr14

62203827

+SF3B1chr2

198283312

-
intron-intronENST00000557206ENST00000414963HIF1Achr14

62203827

+SF3B1chr2

198283312

-
intron-intronENST00000557206ENST00000462613HIF1Achr14

62203827

+SF3B1chr2

198283312

-
intron-intronENST00000557206ENST00000487698HIF1Achr14

62203827

+SF3B1chr2

198283312

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394997HIF1Achr1462203827+ENST00000335508SF3B1chr2198283312-7536151726550161583
ENST00000337138HIF1Achr1462203827+ENST00000335508SF3B1chr2198283312-7533151426550131582
ENST00000323441HIF1Achr1462203827+ENST00000335508SF3B1chr2198283312-729612772847761582
ENST00000557538HIF1Achr1462203827+ENST00000335508SF3B1chr2198283312-7569155022950491606
ENST00000539097HIF1Achr1462203827+ENST00000335508SF3B1chr2198283312-7569155022950491606

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394997ENST00000335508HIF1Achr1462203827+SF3B1chr2198283312-0.0001492590.99985075
ENST00000337138ENST00000335508HIF1Achr1462203827+SF3B1chr2198283312-0.0001498860.99985003
ENST00000323441ENST00000335508HIF1Achr1462203827+SF3B1chr2198283312-0.0001162030.9998838
ENST00000557538ENST00000335508HIF1Achr1462203827+SF3B1chr2198283312-0.0001271140.9998729
ENST00000539097ENST00000335508HIF1Achr1462203827+SF3B1chr2198283312-0.0001271140.9998729

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Fusion Genomic Features for HIF1A-SF3B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIF1A-SF3B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:62203827/chr2:198283312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIF1A

Q16665

.
FUNCTION: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent proinflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+91417_70416736.0DomainbHLH
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914228_298416736.0DomainPAS 2
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914302_345416736.0DomainNote=PAC
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+91485_158416736.0DomainPAS 1
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+91517_70416827.0DomainbHLH
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915228_298416827.0DomainPAS 2
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915302_345416827.0DomainNote=PAC
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+91585_158416827.0DomainPAS 1
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+91517_70440851.0DomainbHLH
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915228_298440851.0DomainPAS 2
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915302_345440851.0DomainNote=PAC
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+91585_158440851.0DomainPAS 1
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914170_191416736.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+91421_30416736.0RegionDNA-binding
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914380_417416736.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915170_191416827.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+91521_30416827.0RegionDNA-binding
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915380_417416827.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915170_191440851.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+91521_30440851.0RegionDNA-binding
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915380_417440851.0RegionNote=N-terminal VHL recognition site
TgeneSF3B1chr14:62203827chr2:198283312ENST000003355083251010_10481381305.0RepeatNote=HEAT 8
TgeneSF3B1chr14:62203827chr2:198283312ENST000003355083251052_10901381305.0RepeatNote=HEAT 9
TgeneSF3B1chr14:62203827chr2:198283312ENST000003355083251122_11601381305.0RepeatNote=HEAT 10
TgeneSF3B1chr14:62203827chr2:198283312ENST000003355083251163_12011381305.0RepeatNote=HEAT 11
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325569_6031381305.0RepeatNote=HEAT 2
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325604_6411381305.0RepeatNote=HEAT 3
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325643_6771381305.0RepeatNote=HEAT 4
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325680_7181381305.0RepeatNote=HEAT 5
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325763_8011381305.0RepeatNote=HEAT 6
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325843_8811381305.0RepeatNote=HEAT 7
TgeneSF3B1chr14:62203827chr2:198283312ENST00000409915471010_104815788.0RepeatNote=HEAT 8
TgeneSF3B1chr14:62203827chr2:198283312ENST00000409915471052_109015788.0RepeatNote=HEAT 9
TgeneSF3B1chr14:62203827chr2:198283312ENST00000409915471122_116015788.0RepeatNote=HEAT 10
TgeneSF3B1chr14:62203827chr2:198283312ENST00000409915471163_120115788.0RepeatNote=HEAT 11
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547569_60315788.0RepeatNote=HEAT 2
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547604_64115788.0RepeatNote=HEAT 3
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547643_67715788.0RepeatNote=HEAT 4
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547680_71815788.0RepeatNote=HEAT 5
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547763_80115788.0RepeatNote=HEAT 6
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547843_88115788.0RepeatNote=HEAT 7
TgeneSF3B1chr14:62203827chr2:198283312ENST00000414963051010_10480145.0RepeatNote=HEAT 8
TgeneSF3B1chr14:62203827chr2:198283312ENST00000414963051052_10900145.0RepeatNote=HEAT 9
TgeneSF3B1chr14:62203827chr2:198283312ENST00000414963051122_11600145.0RepeatNote=HEAT 10
TgeneSF3B1chr14:62203827chr2:198283312ENST00000414963051163_12010145.0RepeatNote=HEAT 11
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305569_6030145.0RepeatNote=HEAT 2
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305604_6410145.0RepeatNote=HEAT 3
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305643_6770145.0RepeatNote=HEAT 4
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305680_7180145.0RepeatNote=HEAT 5
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305763_8010145.0RepeatNote=HEAT 6
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305843_8810145.0RepeatNote=HEAT 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914615_621416736.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915615_621416827.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915615_621440851.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914718_721416736.0MotifNuclear localization signal
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915718_721416827.0MotifNuclear localization signal
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915718_721440851.0MotifNuclear localization signal
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914401_603416736.0RegionNote=ODD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914531_575416736.0RegionNote=NTAD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914556_572416736.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914576_785416736.0RegionNote=ID
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+914786_826416736.0RegionNote=CTAD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915401_603416827.0RegionNote=ODD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915531_575416827.0RegionNote=NTAD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915556_572416827.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915576_785416827.0RegionNote=ID
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+915786_826416827.0RegionNote=CTAD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915401_603440851.0RegionNote=ODD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915531_575440851.0RegionNote=NTAD
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915556_572440851.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915576_785440851.0RegionNote=ID
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+915786_826440851.0RegionNote=CTAD


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Fusion Gene Sequence for HIF1A-SF3B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36347_36347_1_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000323441_SF3B1_chr2_198283312_ENST00000335508_length(transcript)=7296nt_BP=1277nt
GTGAAGACATCGCGGGGACCGATTCACCATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAA
GTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAG
TTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGA
AGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTA
CATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCA
TGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAAT
GAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATA
TGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATC
AAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGA
ATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCA
TCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGC
AACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGAT
TTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGA
AGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTT
AGATTTTGGCAGCAACGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGGACTTACATGGATGTAATGCGAGAACAACACTTGACTAA
AGAAGAACGAGAAATTAGGCAACAGCTAGCAGAAAAAGCTAAAGCTGGAGAACTAAAAGTCGTCAATGGAGCAGCAGCGTCCCAGCCTCC
ATCAAAACGAAAACGGCGTTGGGATCAAACAGCTGATCAGACTCCTGGTGCCACTCCCAAAAAACTATCAAGTTGGGATCAGGCAGAGAC
CCCTGGGCATACTCCTTCCTTAAGATGGGATGAGACACCAGGTCGTGCAAAGGGAAGCGAGACTCCTGGAGCAACCCCAGGCTCAAAAAT
ATGGGATCCTACACCTAGCCACACACCAGCGGGAGCTGCTACTCCTGGACGAGGTGATACACCAGGCCATGCGACACCAGGCCATGGAGG
CGCAACTTCCAGTGCTCGTAAAAACAGATGGGATGAAACCCCCAAAACAGAGAGAGATACTCCTGGGCATGGAAGTGGATGGGCTGAGAC
TCCTCGAACAGATCGAGGTGGAGATTCTATTGGTGAAACACCGACTCCTGGAGCCAGTAAAAGAAAATCACGGTGGGATGAAACACCAGC
TAGTCAGATGGGTGGAAGCACTCCAGTTCTGACCCCTGGAAAGACACCAATTGGCACACCAGCCATGAACATGGCTACCCCTACTCCAGG
TCACATAATGAGTATGACTCCTGAACAGCTTCAGGCTTGGCGGTGGGAAAGAGAAATTGATGAGAGAAATCGCCCACTTTCTGATGAGGA
ATTAGATGCTATGTTCCCAGAAGGATATAAGGTACTTCCTCCTCCAGCTGGTTATGTTCCTATTCGAACTCCAGCTCGAAAGCTGACAGC
TACTCCAACACCTTTGGGTGGTATGACTGGTTTCCACATGCAAACTGAAGATCGAACTATGAAAAGTGTTAATGACCAGCCATCTGGAAA
TCTTCCATTTTTAAAACCTGATGATATTCAATACTTTGATAAACTATTGGTTGATGTTGATGAATCAACACTTAGTCCAGAAGAGCAAAA
AGAGAGAAAAATAATGAAGTTGCTTTTAAAAATTAAGAATGGAACACCACCAATGAGAAAGGCTGCATTGCGTCAGATTACTGATAAAGC
TCGTGAATTTGGAGCTGGTCCTTTGTTTAATCAGATTCTTCCTCTGCTGATGTCTCCTACACTTGAGGATCAAGAGCGTCATTTACTTGT
GAAAGTTATTGATAGGATACTGTACAAACTTGATGACTTAGTTCGTCCATATGTGCATAAGATCCTCGTGGTCATTGAACCGCTATTGAT
TGATGAAGATTACTATGCTAGAGTGGAAGGCCGAGAGATCATTTCTAATTTGGCAAAGGCTGCTGGTCTGGCTACTATGATCTCTACCAT
GAGACCTGATATAGATAACATGGATGAGTATGTCCGTAACACAACAGCTAGAGCTTTTGCTGTTGTAGCCTCTGCCCTGGGCATTCCTTC
TTTATTGCCCTTCTTAAAAGCTGTGTGCAAAAGCAAGAAGTCCTGGCAAGCGAGACACACTGGTATTAAGATTGTACAACAGATAGCTAT
TCTTATGGGCTGTGCCATCTTGCCACATCTTAGAAGTTTAGTTGAAATCATTGAACATGGTCTTGTGGATGAGCAGCAGAAAGTTCGGAC
CATCAGTGCTTTGGCCATTGCTGCCTTGGCTGAAGCAGCAACTCCTTATGGTATCGAATCTTTTGATTCTGTGTTAAAGCCTTTATGGAA
GGGTATCCGCCAACACAGAGGAAAGGGTTTGGCTGCTTTCTTGAAGGCTATTGGGTATCTTATTCCTCTTATGGATGCAGAATATGCCAA
CTACTATACTAGAGAAGTGATGTTAATCCTTATTCGAGAATTCCAGTCTCCTGATGAGGAAATGAAAAAAATTGTGCTGAAGGTGGTAAA
ACAGTGTTGTGGGACAGATGGTGTAGAAGCAAACTACATTAAAACAGAGATTCTTCCTCCCTTTTTTAAACACTTCTGGCAGCACAGGAT
GGCTTTGGATAGAAGAAATTACCGACAGTTAGTTGATACTACTGTGGAGTTGGCAAACAAAGTAGGTGCAGCAGAAATTATATCCAGGAT
TGTGGATGATCTGAAAGATGAAGCCGAACAGTACAGAAAAATGGTGATGGAGACAATTGAGAAAATTATGGGTAATTTGGGAGCAGCAGA
TATTGATCATAAACTTGAAGAACAACTGATTGATGGTATTCTTTATGCTTTCCAAGAACAGACTACAGAGGACTCAGTAATGTTGAACGG
CTTTGGCACAGTGGTTAATGCTCTTGGCAAACGAGTCAAACCATACTTGCCTCAGATCTGTGGTACAGTTTTGTGGCGTTTAAATAACAA
ATCTGCTAAAGTTAGGCAACAGGCAGCTGACTTGATTTCTCGAACTGCTGTTGTCATGAAGACTTGTCAAGAGGAAAAATTGATGGGACA
CTTGGGTGTTGTATTGTATGAGTATTTGGGTGAAGAGTACCCTGAAGTATTGGGCAGCATTCTTGGAGCACTGAAGGCCATTGTAAATGT
CATAGGTATGCATAAGATGACTCCACCAATTAAAGATCTGCTGCCTAGACTCACCCCCATCTTAAAGAACAGACATGAAAAAGTACAAGA
GAATTGTATTGATCTTGTTGGTCGTATTGCTGACAGGGGAGCTGAATATGTATCTGCAAGAGAGTGGATGAGGATTTGCTTTGAGCTTTT
AGAGCTCTTAAAAGCCCACAAAAAGGCTATTCGTAGAGCCACAGTCAACACATTTGGTTATATTGCAAAGGCCATTGGCCCTCATGATGT
ATTGGCTACACTTCTGAACAACCTCAAAGTTCAAGAAAGGCAGAACAGAGTTTGTACCACTGTAGCAATAGCTATTGTTGCAGAAACATG
TTCACCCTTTACAGTACTCCCTGCCTTAATGAATGAATACAGAGTTCCTGAACTGAATGTTCAAAATGGAGTGTTAAAATCGCTTTCCTT
CTTGTTTGAATATATTGGTGAAATGGGAAAAGACTACATTTATGCCGTAACACCGTTACTTGAAGATGCTTTAATGGATAGAGACCTTGT
ACACAGACAGACGGCTAGTGCAGTGGTACAGCACATGTCACTTGGGGTTTATGGATTTGGTTGTGAAGATTCGCTGAATCACTTGTTGAA
CTATGTATGGCCCAATGTATTTGAGACATCTCCTCATGTAATTCAGGCAGTTATGGGAGCCCTAGAGGGCCTGAGAGTTGCTATTGGACC
ATGTAGAATGTTGCAATATTGTTTACAGGGTCTGTTTCACCCAGCCCGGAAAGTCAGAGATGTATATTGGAAAATTTACAACTCCATCTA
CATTGGTTCCCAGGACGCTCTCATAGCACATTACCCAAGAATCTACAACGATGATAAGAACACCTATATTCGTTATGAACTTGACTATAT
CTTATAATTTTATTGTTTATTTTGTGTTTAATGCACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAACAT
TGCAGATCAGTGTAGAACTGGTCATAGAGGAAGAGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTTGTTTTTGATGTTAAA
CAGTAAATGCCAGTAGTGACCAAGAACACAGTGATTATATACACTATACTGGAGGGATTTCATTTTTAATTCATCTTTATGAAGATTTAG
AACTCATTCCTTGTGTTTAAAGGGAATGTTTAATTGAGAAATAAACATTTGTGTACAAAATGCTAATTTGTGTGTGTTTTTTGAACATGA
CTTGTAAAATGCGGAACTTTGATAAAGTATTGGTTTATGTGGAATAAGTGGCTTAATTTCATTTTCTGTCACATGGTTTATAGAAAGTAG
TTAGCTGAATAAAAACTATATAAAGTGATGGCATCTTTGTCAAAATTCCATTGTTGTGTTAATAATGACAGCAAGAAGAGTAGCCTCAGG
GGATGTTCCCCTCAAACTAGCACAACCATTCCATCATCGTAGAAAAGTAGCACTTTTGCTAAACTGTCTTGAATATTTTGTACTTACATA
GCGCCTTTCATCTCTTGATTTCTCAAAATGCTTTATGAACACATTTAAAGAAAGTGGTTTAAGTCTTGTCCAACACTTGACAGGTCTGCT
GTGTTTAGCAAGTGAGGAATTTAACTTTACTTCAAAACTGCTTTCTGCCTATTAGGAGTGAGGATACCTAAGTAATGCTGATAGAACAGG
ACAATGTTGGGCTTTTCTCCATGTTATAAGCCACTACTCAGCAATGCATCAGTAAATACCTATTCACCCACTGTATGCCAGCCACTGTGC
TTATATGCAGGGGATGCAAAGGTGCATGAGACCTGCCCTCTACCTTTAAGAACAGTATAATGGAGAAGGGGAGACAAACCTTGTGACAGA
TTCCTTATGTACTGTGATAATACACAGTGGCAGCAGCTAAAATGTCTAGGTTTGCTTAGCTTTGTATTCAGTAATAATAAGTTGATCTAA
GAGTTCAGCATAAACTGAATGAAATGCCATTTAATGGTAGAGGAACCAAGCATTAAGGCAGTACTACACTTAATTTTTTAAGCAAATATG
TAAAGTATATTTTCAAACTTTTCTAATGTTATGGCCCCAAATTTCTTAGTTTTGGCCTTTTTACTACCTATACTATTTTTACTGTTTTGT
TTTGTCTCCATGTGGTAGTACTTCTGTGAACTCTAAAGGGAAAAAAAATTCTGCAAGCAGCATTAGTATATAACTACTACTGTAAGTAAA
ACTGCCTATTGACACTTTAGGAGTTCCTGCTTCAGAAGCTTAGTTAAGAAACAGCTTGTGGCCGGGTGTGGTGGCTCATGCCTGTAATCC
CAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACGCGGTGAAGTCCCGTCTACTAAAAA
TACAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCG
GAGCTTGCAGTGAGCCGAGATAGCGCTGCTACACTCCAGCCTGGGCGACAGAGACTCCGTCTCAAAAAAAAAAAAAAAATTGACTTTCAA
CAAATTGATAGTGAGCATTAAGGGTTTCCAAGTTGGATTTGTAACTCCTCATCATTCCTTGTATGACAACTTTCTGAATATATGTCACTA
TGTAGTAAAATTAAACACTCCAAACTCATCTTTCTGTTGTTAGAAGTTTTCAGCGGTACTTCCATGCAACTTTAAATCTCACTGCTCTCT
ATGGTTGATGTCAAATGACCTTCAGTAATGACTGAGAATTGAATACAAATAGATTACAAAGCCAAAATTTGATGTTAAATGACTCAGGAA
ATTTTAGTTGTATTTTCAATTCAAGTACTTAGTAGCCTACGTTTGCTTGGCCTCTGGTTCTTTATGGAAAATAGGCTTTGTAGTGGCATT
GTGGAGCAAAGGAGACTGTTACACCTTAATTAACTTTTTTTACTGATGCAAATAATTTGAGGATAGAGAGGAGGGAAGTAGTGAAAGCTA
TGACCTAAAACATTGGGACCAAATAGAGGCTCACAGATATTTGGATTATTTTATGTGCTTATTATTAAATAAGGAAAGCATTTTGTGATA
TGTGGAAGACGCTATGTGAAGTTTTACCTATCTTCTCAAAGACCTTTTCTTTTGTATTTTCTTTTGGTGTTTCTTAAAGCCAAACAAAGA
AATGTTCTTAAGGAGACAGGGTGGGTTTTTCTGTGGGCCTTTGTTGGTTTTTCTGTGGGCCATCGCCCTCTAATGGAATTGATCTCTGGC
TGTTTGATTTTTTTCATATTGTATTTTTAAAATTTGTTGTACAGTGCCCTGTGAGCACCAAGTACCACTAGATGAATAAAACGTATTATA

>36347_36347_1_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000323441_SF3B1_chr2_198283312_ENST00000335508_length(amino acids)=1582AA_BP=410
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQL
AEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTP
AGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPV
LTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMT
GFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLF
NQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDE
YVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAAL
AEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVE
ANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQL
IDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYL
GEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKA
IRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMG
KDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQ

--------------------------------------------------------------
>36347_36347_2_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000337138_SF3B1_chr2_198283312_ENST00000335508_length(transcript)=7533nt_BP=1514nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAA
AGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCT
TACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTTTTA
TTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGGATT
AACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAGAAA
TGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAACTAT
GAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGGGTA
TAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGACTTT
CCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTTAGG
CCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCACCAC
AGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCAACC
ACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAA
ACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAA
GGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGGAGGGAAAACCCCTGA
TCCTAAAATGAATGCTAGGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAACGAGAAATTAGGCAACAGCTAGCAGA
AAAAGCTAAAGCTGGAGAACTAAAAGTCGTCAATGGAGCAGCAGCGTCCCAGCCTCCATCAAAACGAAAACGGCGTTGGGATCAAACAGC
TGATCAGACTCCTGGTGCCACTCCCAAAAAACTATCAAGTTGGGATCAGGCAGAGACCCCTGGGCATACTCCTTCCTTAAGATGGGATGA
GACACCAGGTCGTGCAAAGGGAAGCGAGACTCCTGGAGCAACCCCAGGCTCAAAAATATGGGATCCTACACCTAGCCACACACCAGCGGG
AGCTGCTACTCCTGGACGAGGTGATACACCAGGCCATGCGACACCAGGCCATGGAGGCGCAACTTCCAGTGCTCGTAAAAACAGATGGGA
TGAAACCCCCAAAACAGAGAGAGATACTCCTGGGCATGGAAGTGGATGGGCTGAGACTCCTCGAACAGATCGAGGTGGAGATTCTATTGG
TGAAACACCGACTCCTGGAGCCAGTAAAAGAAAATCACGGTGGGATGAAACACCAGCTAGTCAGATGGGTGGAAGCACTCCAGTTCTGAC
CCCTGGAAAGACACCAATTGGCACACCAGCCATGAACATGGCTACCCCTACTCCAGGTCACATAATGAGTATGACTCCTGAACAGCTTCA
GGCTTGGCGGTGGGAAAGAGAAATTGATGAGAGAAATCGCCCACTTTCTGATGAGGAATTAGATGCTATGTTCCCAGAAGGATATAAGGT
ACTTCCTCCTCCAGCTGGTTATGTTCCTATTCGAACTCCAGCTCGAAAGCTGACAGCTACTCCAACACCTTTGGGTGGTATGACTGGTTT
CCACATGCAAACTGAAGATCGAACTATGAAAAGTGTTAATGACCAGCCATCTGGAAATCTTCCATTTTTAAAACCTGATGATATTCAATA
CTTTGATAAACTATTGGTTGATGTTGATGAATCAACACTTAGTCCAGAAGAGCAAAAAGAGAGAAAAATAATGAAGTTGCTTTTAAAAAT
TAAGAATGGAACACCACCAATGAGAAAGGCTGCATTGCGTCAGATTACTGATAAAGCTCGTGAATTTGGAGCTGGTCCTTTGTTTAATCA
GATTCTTCCTCTGCTGATGTCTCCTACACTTGAGGATCAAGAGCGTCATTTACTTGTGAAAGTTATTGATAGGATACTGTACAAACTTGA
TGACTTAGTTCGTCCATATGTGCATAAGATCCTCGTGGTCATTGAACCGCTATTGATTGATGAAGATTACTATGCTAGAGTGGAAGGCCG
AGAGATCATTTCTAATTTGGCAAAGGCTGCTGGTCTGGCTACTATGATCTCTACCATGAGACCTGATATAGATAACATGGATGAGTATGT
CCGTAACACAACAGCTAGAGCTTTTGCTGTTGTAGCCTCTGCCCTGGGCATTCCTTCTTTATTGCCCTTCTTAAAAGCTGTGTGCAAAAG
CAAGAAGTCCTGGCAAGCGAGACACACTGGTATTAAGATTGTACAACAGATAGCTATTCTTATGGGCTGTGCCATCTTGCCACATCTTAG
AAGTTTAGTTGAAATCATTGAACATGGTCTTGTGGATGAGCAGCAGAAAGTTCGGACCATCAGTGCTTTGGCCATTGCTGCCTTGGCTGA
AGCAGCAACTCCTTATGGTATCGAATCTTTTGATTCTGTGTTAAAGCCTTTATGGAAGGGTATCCGCCAACACAGAGGAAAGGGTTTGGC
TGCTTTCTTGAAGGCTATTGGGTATCTTATTCCTCTTATGGATGCAGAATATGCCAACTACTATACTAGAGAAGTGATGTTAATCCTTAT
TCGAGAATTCCAGTCTCCTGATGAGGAAATGAAAAAAATTGTGCTGAAGGTGGTAAAACAGTGTTGTGGGACAGATGGTGTAGAAGCAAA
CTACATTAAAACAGAGATTCTTCCTCCCTTTTTTAAACACTTCTGGCAGCACAGGATGGCTTTGGATAGAAGAAATTACCGACAGTTAGT
TGATACTACTGTGGAGTTGGCAAACAAAGTAGGTGCAGCAGAAATTATATCCAGGATTGTGGATGATCTGAAAGATGAAGCCGAACAGTA
CAGAAAAATGGTGATGGAGACAATTGAGAAAATTATGGGTAATTTGGGAGCAGCAGATATTGATCATAAACTTGAAGAACAACTGATTGA
TGGTATTCTTTATGCTTTCCAAGAACAGACTACAGAGGACTCAGTAATGTTGAACGGCTTTGGCACAGTGGTTAATGCTCTTGGCAAACG
AGTCAAACCATACTTGCCTCAGATCTGTGGTACAGTTTTGTGGCGTTTAAATAACAAATCTGCTAAAGTTAGGCAACAGGCAGCTGACTT
GATTTCTCGAACTGCTGTTGTCATGAAGACTTGTCAAGAGGAAAAATTGATGGGACACTTGGGTGTTGTATTGTATGAGTATTTGGGTGA
AGAGTACCCTGAAGTATTGGGCAGCATTCTTGGAGCACTGAAGGCCATTGTAAATGTCATAGGTATGCATAAGATGACTCCACCAATTAA
AGATCTGCTGCCTAGACTCACCCCCATCTTAAAGAACAGACATGAAAAAGTACAAGAGAATTGTATTGATCTTGTTGGTCGTATTGCTGA
CAGGGGAGCTGAATATGTATCTGCAAGAGAGTGGATGAGGATTTGCTTTGAGCTTTTAGAGCTCTTAAAAGCCCACAAAAAGGCTATTCG
TAGAGCCACAGTCAACACATTTGGTTATATTGCAAAGGCCATTGGCCCTCATGATGTATTGGCTACACTTCTGAACAACCTCAAAGTTCA
AGAAAGGCAGAACAGAGTTTGTACCACTGTAGCAATAGCTATTGTTGCAGAAACATGTTCACCCTTTACAGTACTCCCTGCCTTAATGAA
TGAATACAGAGTTCCTGAACTGAATGTTCAAAATGGAGTGTTAAAATCGCTTTCCTTCTTGTTTGAATATATTGGTGAAATGGGAAAAGA
CTACATTTATGCCGTAACACCGTTACTTGAAGATGCTTTAATGGATAGAGACCTTGTACACAGACAGACGGCTAGTGCAGTGGTACAGCA
CATGTCACTTGGGGTTTATGGATTTGGTTGTGAAGATTCGCTGAATCACTTGTTGAACTATGTATGGCCCAATGTATTTGAGACATCTCC
TCATGTAATTCAGGCAGTTATGGGAGCCCTAGAGGGCCTGAGAGTTGCTATTGGACCATGTAGAATGTTGCAATATTGTTTACAGGGTCT
GTTTCACCCAGCCCGGAAAGTCAGAGATGTATATTGGAAAATTTACAACTCCATCTACATTGGTTCCCAGGACGCTCTCATAGCACATTA
CCCAAGAATCTACAACGATGATAAGAACACCTATATTCGTTATGAACTTGACTATATCTTATAATTTTATTGTTTATTTTGTGTTTAATG
CACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAACATTGCAGATCAGTGTAGAACTGGTCATAGAGGAAG
AGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTTGTTTTTGATGTTAAACAGTAAATGCCAGTAGTGACCAAGAACACAGTG
ATTATATACACTATACTGGAGGGATTTCATTTTTAATTCATCTTTATGAAGATTTAGAACTCATTCCTTGTGTTTAAAGGGAATGTTTAA
TTGAGAAATAAACATTTGTGTACAAAATGCTAATTTGTGTGTGTTTTTTGAACATGACTTGTAAAATGCGGAACTTTGATAAAGTATTGG
TTTATGTGGAATAAGTGGCTTAATTTCATTTTCTGTCACATGGTTTATAGAAAGTAGTTAGCTGAATAAAAACTATATAAAGTGATGGCA
TCTTTGTCAAAATTCCATTGTTGTGTTAATAATGACAGCAAGAAGAGTAGCCTCAGGGGATGTTCCCCTCAAACTAGCACAACCATTCCA
TCATCGTAGAAAAGTAGCACTTTTGCTAAACTGTCTTGAATATTTTGTACTTACATAGCGCCTTTCATCTCTTGATTTCTCAAAATGCTT
TATGAACACATTTAAAGAAAGTGGTTTAAGTCTTGTCCAACACTTGACAGGTCTGCTGTGTTTAGCAAGTGAGGAATTTAACTTTACTTC
AAAACTGCTTTCTGCCTATTAGGAGTGAGGATACCTAAGTAATGCTGATAGAACAGGACAATGTTGGGCTTTTCTCCATGTTATAAGCCA
CTACTCAGCAATGCATCAGTAAATACCTATTCACCCACTGTATGCCAGCCACTGTGCTTATATGCAGGGGATGCAAAGGTGCATGAGACC
TGCCCTCTACCTTTAAGAACAGTATAATGGAGAAGGGGAGACAAACCTTGTGACAGATTCCTTATGTACTGTGATAATACACAGTGGCAG
CAGCTAAAATGTCTAGGTTTGCTTAGCTTTGTATTCAGTAATAATAAGTTGATCTAAGAGTTCAGCATAAACTGAATGAAATGCCATTTA
ATGGTAGAGGAACCAAGCATTAAGGCAGTACTACACTTAATTTTTTAAGCAAATATGTAAAGTATATTTTCAAACTTTTCTAATGTTATG
GCCCCAAATTTCTTAGTTTTGGCCTTTTTACTACCTATACTATTTTTACTGTTTTGTTTTGTCTCCATGTGGTAGTACTTCTGTGAACTC
TAAAGGGAAAAAAAATTCTGCAAGCAGCATTAGTATATAACTACTACTGTAAGTAAAACTGCCTATTGACACTTTAGGAGTTCCTGCTTC
AGAAGCTTAGTTAAGAAACAGCTTGTGGCCGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCAC
GAGGTCAGGAGATCGAGACCATCCTGGCTAACGCGGTGAAGTCCCGTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGGGCGCC
TGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATAGCGCTGCTACA
CTCCAGCCTGGGCGACAGAGACTCCGTCTCAAAAAAAAAAAAAAAATTGACTTTCAACAAATTGATAGTGAGCATTAAGGGTTTCCAAGT
TGGATTTGTAACTCCTCATCATTCCTTGTATGACAACTTTCTGAATATATGTCACTATGTAGTAAAATTAAACACTCCAAACTCATCTTT
CTGTTGTTAGAAGTTTTCAGCGGTACTTCCATGCAACTTTAAATCTCACTGCTCTCTATGGTTGATGTCAAATGACCTTCAGTAATGACT
GAGAATTGAATACAAATAGATTACAAAGCCAAAATTTGATGTTAAATGACTCAGGAAATTTTAGTTGTATTTTCAATTCAAGTACTTAGT
AGCCTACGTTTGCTTGGCCTCTGGTTCTTTATGGAAAATAGGCTTTGTAGTGGCATTGTGGAGCAAAGGAGACTGTTACACCTTAATTAA
CTTTTTTTACTGATGCAAATAATTTGAGGATAGAGAGGAGGGAAGTAGTGAAAGCTATGACCTAAAACATTGGGACCAAATAGAGGCTCA
CAGATATTTGGATTATTTTATGTGCTTATTATTAAATAAGGAAAGCATTTTGTGATATGTGGAAGACGCTATGTGAAGTTTTACCTATCT
TCTCAAAGACCTTTTCTTTTGTATTTTCTTTTGGTGTTTCTTAAAGCCAAACAAAGAAATGTTCTTAAGGAGACAGGGTGGGTTTTTCTG
TGGGCCTTTGTTGGTTTTTCTGTGGGCCATCGCCCTCTAATGGAATTGATCTCTGGCTGTTTGATTTTTTTCATATTGTATTTTTAAAAT

>36347_36347_2_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000337138_SF3B1_chr2_198283312_ENST00000335508_length(amino acids)=1582AA_BP=410
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQL
AEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHTP
AGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPV
LTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGMT
GFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLF
NQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDE
YVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAAL
AEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVE
ANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQL
IDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYL
GEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKA
IRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMG
KDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQ

--------------------------------------------------------------
>36347_36347_3_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000394997_SF3B1_chr2_198283312_ENST00000335508_length(transcript)=7536nt_BP=1517nt
GACAGGAGGATCACCCTCTTCGTCGCTTCGGCCAGTGTGTCGGGCTGGGCCCTGACAAGCCACCTGAGGAGAGGCTCGGAGCCGGGCCCG
GACCCCGGCGATTGCCGCCCGCTTCTCTCTAGTCTCACGAGGGGTTTCCCGCCTCGCACCCCCACCTCTGGACTTGCCTTTCCTTCTCTT
CTCCGCGTGTGGAGGGAGCCAGCGCTTAGGCCGGAGCGAGCCTGGGGGCCGCCCGCCGTGAAGACATCGCGGGGACCGATTCACCATGGA
GGGCGCCGGCGGCGCGAACGACAAGAAAAATAGGATAAGTTCTGAACGTCGAAAAGAAAAGTCTCGAGATGCAGCCAGATCTCGGCGAAG
TAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATGAG
GCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATTGAAGATGACATGAAAGCACAGATGAATTGCTT
TTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATGGG
ATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGACCATGAGGAAATGAGAGAAATGCTTACACACAG
AAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGAAC
TATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTATATGATACCAACAGTAACCAACCTCAGTGTGG
GTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAGAC
TTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACCGAATTGATGGGATATGAGCCAGAAGAACTTTT
AGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTCAC
CACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAAGCAACTGTCATATATAACACCAAGAATTCTCA
ACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTCCT
TAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCAGAAGATACAAGTAGCCTCTTTGACAAACTTAA
GAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGGAGGGAAAACCCC
TGATCCTAAAATGAATGCTAGGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAACGAGAAATTAGGCAACAGCTAGC
AGAAAAAGCTAAAGCTGGAGAACTAAAAGTCGTCAATGGAGCAGCAGCGTCCCAGCCTCCATCAAAACGAAAACGGCGTTGGGATCAAAC
AGCTGATCAGACTCCTGGTGCCACTCCCAAAAAACTATCAAGTTGGGATCAGGCAGAGACCCCTGGGCATACTCCTTCCTTAAGATGGGA
TGAGACACCAGGTCGTGCAAAGGGAAGCGAGACTCCTGGAGCAACCCCAGGCTCAAAAATATGGGATCCTACACCTAGCCACACACCAGC
GGGAGCTGCTACTCCTGGACGAGGTGATACACCAGGCCATGCGACACCAGGCCATGGAGGCGCAACTTCCAGTGCTCGTAAAAACAGATG
GGATGAAACCCCCAAAACAGAGAGAGATACTCCTGGGCATGGAAGTGGATGGGCTGAGACTCCTCGAACAGATCGAGGTGGAGATTCTAT
TGGTGAAACACCGACTCCTGGAGCCAGTAAAAGAAAATCACGGTGGGATGAAACACCAGCTAGTCAGATGGGTGGAAGCACTCCAGTTCT
GACCCCTGGAAAGACACCAATTGGCACACCAGCCATGAACATGGCTACCCCTACTCCAGGTCACATAATGAGTATGACTCCTGAACAGCT
TCAGGCTTGGCGGTGGGAAAGAGAAATTGATGAGAGAAATCGCCCACTTTCTGATGAGGAATTAGATGCTATGTTCCCAGAAGGATATAA
GGTACTTCCTCCTCCAGCTGGTTATGTTCCTATTCGAACTCCAGCTCGAAAGCTGACAGCTACTCCAACACCTTTGGGTGGTATGACTGG
TTTCCACATGCAAACTGAAGATCGAACTATGAAAAGTGTTAATGACCAGCCATCTGGAAATCTTCCATTTTTAAAACCTGATGATATTCA
ATACTTTGATAAACTATTGGTTGATGTTGATGAATCAACACTTAGTCCAGAAGAGCAAAAAGAGAGAAAAATAATGAAGTTGCTTTTAAA
AATTAAGAATGGAACACCACCAATGAGAAAGGCTGCATTGCGTCAGATTACTGATAAAGCTCGTGAATTTGGAGCTGGTCCTTTGTTTAA
TCAGATTCTTCCTCTGCTGATGTCTCCTACACTTGAGGATCAAGAGCGTCATTTACTTGTGAAAGTTATTGATAGGATACTGTACAAACT
TGATGACTTAGTTCGTCCATATGTGCATAAGATCCTCGTGGTCATTGAACCGCTATTGATTGATGAAGATTACTATGCTAGAGTGGAAGG
CCGAGAGATCATTTCTAATTTGGCAAAGGCTGCTGGTCTGGCTACTATGATCTCTACCATGAGACCTGATATAGATAACATGGATGAGTA
TGTCCGTAACACAACAGCTAGAGCTTTTGCTGTTGTAGCCTCTGCCCTGGGCATTCCTTCTTTATTGCCCTTCTTAAAAGCTGTGTGCAA
AAGCAAGAAGTCCTGGCAAGCGAGACACACTGGTATTAAGATTGTACAACAGATAGCTATTCTTATGGGCTGTGCCATCTTGCCACATCT
TAGAAGTTTAGTTGAAATCATTGAACATGGTCTTGTGGATGAGCAGCAGAAAGTTCGGACCATCAGTGCTTTGGCCATTGCTGCCTTGGC
TGAAGCAGCAACTCCTTATGGTATCGAATCTTTTGATTCTGTGTTAAAGCCTTTATGGAAGGGTATCCGCCAACACAGAGGAAAGGGTTT
GGCTGCTTTCTTGAAGGCTATTGGGTATCTTATTCCTCTTATGGATGCAGAATATGCCAACTACTATACTAGAGAAGTGATGTTAATCCT
TATTCGAGAATTCCAGTCTCCTGATGAGGAAATGAAAAAAATTGTGCTGAAGGTGGTAAAACAGTGTTGTGGGACAGATGGTGTAGAAGC
AAACTACATTAAAACAGAGATTCTTCCTCCCTTTTTTAAACACTTCTGGCAGCACAGGATGGCTTTGGATAGAAGAAATTACCGACAGTT
AGTTGATACTACTGTGGAGTTGGCAAACAAAGTAGGTGCAGCAGAAATTATATCCAGGATTGTGGATGATCTGAAAGATGAAGCCGAACA
GTACAGAAAAATGGTGATGGAGACAATTGAGAAAATTATGGGTAATTTGGGAGCAGCAGATATTGATCATAAACTTGAAGAACAACTGAT
TGATGGTATTCTTTATGCTTTCCAAGAACAGACTACAGAGGACTCAGTAATGTTGAACGGCTTTGGCACAGTGGTTAATGCTCTTGGCAA
ACGAGTCAAACCATACTTGCCTCAGATCTGTGGTACAGTTTTGTGGCGTTTAAATAACAAATCTGCTAAAGTTAGGCAACAGGCAGCTGA
CTTGATTTCTCGAACTGCTGTTGTCATGAAGACTTGTCAAGAGGAAAAATTGATGGGACACTTGGGTGTTGTATTGTATGAGTATTTGGG
TGAAGAGTACCCTGAAGTATTGGGCAGCATTCTTGGAGCACTGAAGGCCATTGTAAATGTCATAGGTATGCATAAGATGACTCCACCAAT
TAAAGATCTGCTGCCTAGACTCACCCCCATCTTAAAGAACAGACATGAAAAAGTACAAGAGAATTGTATTGATCTTGTTGGTCGTATTGC
TGACAGGGGAGCTGAATATGTATCTGCAAGAGAGTGGATGAGGATTTGCTTTGAGCTTTTAGAGCTCTTAAAAGCCCACAAAAAGGCTAT
TCGTAGAGCCACAGTCAACACATTTGGTTATATTGCAAAGGCCATTGGCCCTCATGATGTATTGGCTACACTTCTGAACAACCTCAAAGT
TCAAGAAAGGCAGAACAGAGTTTGTACCACTGTAGCAATAGCTATTGTTGCAGAAACATGTTCACCCTTTACAGTACTCCCTGCCTTAAT
GAATGAATACAGAGTTCCTGAACTGAATGTTCAAAATGGAGTGTTAAAATCGCTTTCCTTCTTGTTTGAATATATTGGTGAAATGGGAAA
AGACTACATTTATGCCGTAACACCGTTACTTGAAGATGCTTTAATGGATAGAGACCTTGTACACAGACAGACGGCTAGTGCAGTGGTACA
GCACATGTCACTTGGGGTTTATGGATTTGGTTGTGAAGATTCGCTGAATCACTTGTTGAACTATGTATGGCCCAATGTATTTGAGACATC
TCCTCATGTAATTCAGGCAGTTATGGGAGCCCTAGAGGGCCTGAGAGTTGCTATTGGACCATGTAGAATGTTGCAATATTGTTTACAGGG
TCTGTTTCACCCAGCCCGGAAAGTCAGAGATGTATATTGGAAAATTTACAACTCCATCTACATTGGTTCCCAGGACGCTCTCATAGCACA
TTACCCAAGAATCTACAACGATGATAAGAACACCTATATTCGTTATGAACTTGACTATATCTTATAATTTTATTGTTTATTTTGTGTTTA
ATGCACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAACATTGCAGATCAGTGTAGAACTGGTCATAGAGG
AAGAGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTTGTTTTTGATGTTAAACAGTAAATGCCAGTAGTGACCAAGAACACA
GTGATTATATACACTATACTGGAGGGATTTCATTTTTAATTCATCTTTATGAAGATTTAGAACTCATTCCTTGTGTTTAAAGGGAATGTT
TAATTGAGAAATAAACATTTGTGTACAAAATGCTAATTTGTGTGTGTTTTTTGAACATGACTTGTAAAATGCGGAACTTTGATAAAGTAT
TGGTTTATGTGGAATAAGTGGCTTAATTTCATTTTCTGTCACATGGTTTATAGAAAGTAGTTAGCTGAATAAAAACTATATAAAGTGATG
GCATCTTTGTCAAAATTCCATTGTTGTGTTAATAATGACAGCAAGAAGAGTAGCCTCAGGGGATGTTCCCCTCAAACTAGCACAACCATT
CCATCATCGTAGAAAAGTAGCACTTTTGCTAAACTGTCTTGAATATTTTGTACTTACATAGCGCCTTTCATCTCTTGATTTCTCAAAATG
CTTTATGAACACATTTAAAGAAAGTGGTTTAAGTCTTGTCCAACACTTGACAGGTCTGCTGTGTTTAGCAAGTGAGGAATTTAACTTTAC
TTCAAAACTGCTTTCTGCCTATTAGGAGTGAGGATACCTAAGTAATGCTGATAGAACAGGACAATGTTGGGCTTTTCTCCATGTTATAAG
CCACTACTCAGCAATGCATCAGTAAATACCTATTCACCCACTGTATGCCAGCCACTGTGCTTATATGCAGGGGATGCAAAGGTGCATGAG
ACCTGCCCTCTACCTTTAAGAACAGTATAATGGAGAAGGGGAGACAAACCTTGTGACAGATTCCTTATGTACTGTGATAATACACAGTGG
CAGCAGCTAAAATGTCTAGGTTTGCTTAGCTTTGTATTCAGTAATAATAAGTTGATCTAAGAGTTCAGCATAAACTGAATGAAATGCCAT
TTAATGGTAGAGGAACCAAGCATTAAGGCAGTACTACACTTAATTTTTTAAGCAAATATGTAAAGTATATTTTCAAACTTTTCTAATGTT
ATGGCCCCAAATTTCTTAGTTTTGGCCTTTTTACTACCTATACTATTTTTACTGTTTTGTTTTGTCTCCATGTGGTAGTACTTCTGTGAA
CTCTAAAGGGAAAAAAAATTCTGCAAGCAGCATTAGTATATAACTACTACTGTAAGTAAAACTGCCTATTGACACTTTAGGAGTTCCTGC
TTCAGAAGCTTAGTTAAGAAACAGCTTGTGGCCGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGAT
CACGAGGTCAGGAGATCGAGACCATCCTGGCTAACGCGGTGAAGTCCCGTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCGGGC
GCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATAGCGCTGCT
ACACTCCAGCCTGGGCGACAGAGACTCCGTCTCAAAAAAAAAAAAAAAATTGACTTTCAACAAATTGATAGTGAGCATTAAGGGTTTCCA
AGTTGGATTTGTAACTCCTCATCATTCCTTGTATGACAACTTTCTGAATATATGTCACTATGTAGTAAAATTAAACACTCCAAACTCATC
TTTCTGTTGTTAGAAGTTTTCAGCGGTACTTCCATGCAACTTTAAATCTCACTGCTCTCTATGGTTGATGTCAAATGACCTTCAGTAATG
ACTGAGAATTGAATACAAATAGATTACAAAGCCAAAATTTGATGTTAAATGACTCAGGAAATTTTAGTTGTATTTTCAATTCAAGTACTT
AGTAGCCTACGTTTGCTTGGCCTCTGGTTCTTTATGGAAAATAGGCTTTGTAGTGGCATTGTGGAGCAAAGGAGACTGTTACACCTTAAT
TAACTTTTTTTACTGATGCAAATAATTTGAGGATAGAGAGGAGGGAAGTAGTGAAAGCTATGACCTAAAACATTGGGACCAAATAGAGGC
TCACAGATATTTGGATTATTTTATGTGCTTATTATTAAATAAGGAAAGCATTTTGTGATATGTGGAAGACGCTATGTGAAGTTTTACCTA
TCTTCTCAAAGACCTTTTCTTTTGTATTTTCTTTTGGTGTTTCTTAAAGCCAAACAAAGAAATGTTCTTAAGGAGACAGGGTGGGTTTTT
CTGTGGGCCTTTGTTGGTTTTTCTGTGGGCCATCGCCCTCTAATGGAATTGATCTCTGGCTGTTTGATTTTTTTCATATTGTATTTTTAA

>36347_36347_3_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000394997_SF3B1_chr2_198283312_ENST00000335508_length(amino acids)=1583AA_BP=411
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQ
LAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPGSKIWDPTPSHT
PAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTP
VLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAGYVPIRTPARKLTATPTPLGGM
TGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPL
FNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMD
EYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAA
LAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGV
EANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQ
LIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEY
LGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKK
AIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEM
GKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCL

--------------------------------------------------------------
>36347_36347_4_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000539097_SF3B1_chr2_198283312_ENST00000335508_length(transcript)=7569nt_BP=1550nt
ATTTGAAAACTTGGCAACCTTGGATTGGATGGATTCATATTTCTTAGTATAGAAGTTCTTGATATAACTGAAAAATTAAGTTAAACACTT
AATAAGTGGTGGTTACTCAGCACTTTTAGATGCTGTTTATAATAGATGACCTTTTCTAACTAATTTACAGTTTTTTGAAAGATAACTGAG
AGGTTGAGGGACGGAGATTTTCTTCAAGCAATTTTTTTTTTCATTTTAAATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTT
TTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATCAGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGA
AAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGT
GAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATAT
TGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGAT
TTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGA
CCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAG
AATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGT
ATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCC
ATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTAC
CGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAAC
TCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCA
AGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTT
GATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATC
AGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATC
TTTAGATTTTGGCAGCAACGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGGACTTACATGGATGTAATGCGAGAACAACACTTGAC
TAAAGAAGAACGAGAAATTAGGCAACAGCTAGCAGAAAAAGCTAAAGCTGGAGAACTAAAAGTCGTCAATGGAGCAGCAGCGTCCCAGCC
TCCATCAAAACGAAAACGGCGTTGGGATCAAACAGCTGATCAGACTCCTGGTGCCACTCCCAAAAAACTATCAAGTTGGGATCAGGCAGA
GACCCCTGGGCATACTCCTTCCTTAAGATGGGATGAGACACCAGGTCGTGCAAAGGGAAGCGAGACTCCTGGAGCAACCCCAGGCTCAAA
AATATGGGATCCTACACCTAGCCACACACCAGCGGGAGCTGCTACTCCTGGACGAGGTGATACACCAGGCCATGCGACACCAGGCCATGG
AGGCGCAACTTCCAGTGCTCGTAAAAACAGATGGGATGAAACCCCCAAAACAGAGAGAGATACTCCTGGGCATGGAAGTGGATGGGCTGA
GACTCCTCGAACAGATCGAGGTGGAGATTCTATTGGTGAAACACCGACTCCTGGAGCCAGTAAAAGAAAATCACGGTGGGATGAAACACC
AGCTAGTCAGATGGGTGGAAGCACTCCAGTTCTGACCCCTGGAAAGACACCAATTGGCACACCAGCCATGAACATGGCTACCCCTACTCC
AGGTCACATAATGAGTATGACTCCTGAACAGCTTCAGGCTTGGCGGTGGGAAAGAGAAATTGATGAGAGAAATCGCCCACTTTCTGATGA
GGAATTAGATGCTATGTTCCCAGAAGGATATAAGGTACTTCCTCCTCCAGCTGGTTATGTTCCTATTCGAACTCCAGCTCGAAAGCTGAC
AGCTACTCCAACACCTTTGGGTGGTATGACTGGTTTCCACATGCAAACTGAAGATCGAACTATGAAAAGTGTTAATGACCAGCCATCTGG
AAATCTTCCATTTTTAAAACCTGATGATATTCAATACTTTGATAAACTATTGGTTGATGTTGATGAATCAACACTTAGTCCAGAAGAGCA
AAAAGAGAGAAAAATAATGAAGTTGCTTTTAAAAATTAAGAATGGAACACCACCAATGAGAAAGGCTGCATTGCGTCAGATTACTGATAA
AGCTCGTGAATTTGGAGCTGGTCCTTTGTTTAATCAGATTCTTCCTCTGCTGATGTCTCCTACACTTGAGGATCAAGAGCGTCATTTACT
TGTGAAAGTTATTGATAGGATACTGTACAAACTTGATGACTTAGTTCGTCCATATGTGCATAAGATCCTCGTGGTCATTGAACCGCTATT
GATTGATGAAGATTACTATGCTAGAGTGGAAGGCCGAGAGATCATTTCTAATTTGGCAAAGGCTGCTGGTCTGGCTACTATGATCTCTAC
CATGAGACCTGATATAGATAACATGGATGAGTATGTCCGTAACACAACAGCTAGAGCTTTTGCTGTTGTAGCCTCTGCCCTGGGCATTCC
TTCTTTATTGCCCTTCTTAAAAGCTGTGTGCAAAAGCAAGAAGTCCTGGCAAGCGAGACACACTGGTATTAAGATTGTACAACAGATAGC
TATTCTTATGGGCTGTGCCATCTTGCCACATCTTAGAAGTTTAGTTGAAATCATTGAACATGGTCTTGTGGATGAGCAGCAGAAAGTTCG
GACCATCAGTGCTTTGGCCATTGCTGCCTTGGCTGAAGCAGCAACTCCTTATGGTATCGAATCTTTTGATTCTGTGTTAAAGCCTTTATG
GAAGGGTATCCGCCAACACAGAGGAAAGGGTTTGGCTGCTTTCTTGAAGGCTATTGGGTATCTTATTCCTCTTATGGATGCAGAATATGC
CAACTACTATACTAGAGAAGTGATGTTAATCCTTATTCGAGAATTCCAGTCTCCTGATGAGGAAATGAAAAAAATTGTGCTGAAGGTGGT
AAAACAGTGTTGTGGGACAGATGGTGTAGAAGCAAACTACATTAAAACAGAGATTCTTCCTCCCTTTTTTAAACACTTCTGGCAGCACAG
GATGGCTTTGGATAGAAGAAATTACCGACAGTTAGTTGATACTACTGTGGAGTTGGCAAACAAAGTAGGTGCAGCAGAAATTATATCCAG
GATTGTGGATGATCTGAAAGATGAAGCCGAACAGTACAGAAAAATGGTGATGGAGACAATTGAGAAAATTATGGGTAATTTGGGAGCAGC
AGATATTGATCATAAACTTGAAGAACAACTGATTGATGGTATTCTTTATGCTTTCCAAGAACAGACTACAGAGGACTCAGTAATGTTGAA
CGGCTTTGGCACAGTGGTTAATGCTCTTGGCAAACGAGTCAAACCATACTTGCCTCAGATCTGTGGTACAGTTTTGTGGCGTTTAAATAA
CAAATCTGCTAAAGTTAGGCAACAGGCAGCTGACTTGATTTCTCGAACTGCTGTTGTCATGAAGACTTGTCAAGAGGAAAAATTGATGGG
ACACTTGGGTGTTGTATTGTATGAGTATTTGGGTGAAGAGTACCCTGAAGTATTGGGCAGCATTCTTGGAGCACTGAAGGCCATTGTAAA
TGTCATAGGTATGCATAAGATGACTCCACCAATTAAAGATCTGCTGCCTAGACTCACCCCCATCTTAAAGAACAGACATGAAAAAGTACA
AGAGAATTGTATTGATCTTGTTGGTCGTATTGCTGACAGGGGAGCTGAATATGTATCTGCAAGAGAGTGGATGAGGATTTGCTTTGAGCT
TTTAGAGCTCTTAAAAGCCCACAAAAAGGCTATTCGTAGAGCCACAGTCAACACATTTGGTTATATTGCAAAGGCCATTGGCCCTCATGA
TGTATTGGCTACACTTCTGAACAACCTCAAAGTTCAAGAAAGGCAGAACAGAGTTTGTACCACTGTAGCAATAGCTATTGTTGCAGAAAC
ATGTTCACCCTTTACAGTACTCCCTGCCTTAATGAATGAATACAGAGTTCCTGAACTGAATGTTCAAAATGGAGTGTTAAAATCGCTTTC
CTTCTTGTTTGAATATATTGGTGAAATGGGAAAAGACTACATTTATGCCGTAACACCGTTACTTGAAGATGCTTTAATGGATAGAGACCT
TGTACACAGACAGACGGCTAGTGCAGTGGTACAGCACATGTCACTTGGGGTTTATGGATTTGGTTGTGAAGATTCGCTGAATCACTTGTT
GAACTATGTATGGCCCAATGTATTTGAGACATCTCCTCATGTAATTCAGGCAGTTATGGGAGCCCTAGAGGGCCTGAGAGTTGCTATTGG
ACCATGTAGAATGTTGCAATATTGTTTACAGGGTCTGTTTCACCCAGCCCGGAAAGTCAGAGATGTATATTGGAAAATTTACAACTCCAT
CTACATTGGTTCCCAGGACGCTCTCATAGCACATTACCCAAGAATCTACAACGATGATAAGAACACCTATATTCGTTATGAACTTGACTA
TATCTTATAATTTTATTGTTTATTTTGTGTTTAATGCACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAA
CATTGCAGATCAGTGTAGAACTGGTCATAGAGGAAGAGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTTGTTTTTGATGTT
AAACAGTAAATGCCAGTAGTGACCAAGAACACAGTGATTATATACACTATACTGGAGGGATTTCATTTTTAATTCATCTTTATGAAGATT
TAGAACTCATTCCTTGTGTTTAAAGGGAATGTTTAATTGAGAAATAAACATTTGTGTACAAAATGCTAATTTGTGTGTGTTTTTTGAACA
TGACTTGTAAAATGCGGAACTTTGATAAAGTATTGGTTTATGTGGAATAAGTGGCTTAATTTCATTTTCTGTCACATGGTTTATAGAAAG
TAGTTAGCTGAATAAAAACTATATAAAGTGATGGCATCTTTGTCAAAATTCCATTGTTGTGTTAATAATGACAGCAAGAAGAGTAGCCTC
AGGGGATGTTCCCCTCAAACTAGCACAACCATTCCATCATCGTAGAAAAGTAGCACTTTTGCTAAACTGTCTTGAATATTTTGTACTTAC
ATAGCGCCTTTCATCTCTTGATTTCTCAAAATGCTTTATGAACACATTTAAAGAAAGTGGTTTAAGTCTTGTCCAACACTTGACAGGTCT
GCTGTGTTTAGCAAGTGAGGAATTTAACTTTACTTCAAAACTGCTTTCTGCCTATTAGGAGTGAGGATACCTAAGTAATGCTGATAGAAC
AGGACAATGTTGGGCTTTTCTCCATGTTATAAGCCACTACTCAGCAATGCATCAGTAAATACCTATTCACCCACTGTATGCCAGCCACTG
TGCTTATATGCAGGGGATGCAAAGGTGCATGAGACCTGCCCTCTACCTTTAAGAACAGTATAATGGAGAAGGGGAGACAAACCTTGTGAC
AGATTCCTTATGTACTGTGATAATACACAGTGGCAGCAGCTAAAATGTCTAGGTTTGCTTAGCTTTGTATTCAGTAATAATAAGTTGATC
TAAGAGTTCAGCATAAACTGAATGAAATGCCATTTAATGGTAGAGGAACCAAGCATTAAGGCAGTACTACACTTAATTTTTTAAGCAAAT
ATGTAAAGTATATTTTCAAACTTTTCTAATGTTATGGCCCCAAATTTCTTAGTTTTGGCCTTTTTACTACCTATACTATTTTTACTGTTT
TGTTTTGTCTCCATGTGGTAGTACTTCTGTGAACTCTAAAGGGAAAAAAAATTCTGCAAGCAGCATTAGTATATAACTACTACTGTAAGT
AAAACTGCCTATTGACACTTTAGGAGTTCCTGCTTCAGAAGCTTAGTTAAGAAACAGCTTGTGGCCGGGTGTGGTGGCTCATGCCTGTAA
TCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACGCGGTGAAGTCCCGTCTACTAA
AAATACAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAG
GCGGAGCTTGCAGTGAGCCGAGATAGCGCTGCTACACTCCAGCCTGGGCGACAGAGACTCCGTCTCAAAAAAAAAAAAAAAATTGACTTT
CAACAAATTGATAGTGAGCATTAAGGGTTTCCAAGTTGGATTTGTAACTCCTCATCATTCCTTGTATGACAACTTTCTGAATATATGTCA
CTATGTAGTAAAATTAAACACTCCAAACTCATCTTTCTGTTGTTAGAAGTTTTCAGCGGTACTTCCATGCAACTTTAAATCTCACTGCTC
TCTATGGTTGATGTCAAATGACCTTCAGTAATGACTGAGAATTGAATACAAATAGATTACAAAGCCAAAATTTGATGTTAAATGACTCAG
GAAATTTTAGTTGTATTTTCAATTCAAGTACTTAGTAGCCTACGTTTGCTTGGCCTCTGGTTCTTTATGGAAAATAGGCTTTGTAGTGGC
ATTGTGGAGCAAAGGAGACTGTTACACCTTAATTAACTTTTTTTACTGATGCAAATAATTTGAGGATAGAGAGGAGGGAAGTAGTGAAAG
CTATGACCTAAAACATTGGGACCAAATAGAGGCTCACAGATATTTGGATTATTTTATGTGCTTATTATTAAATAAGGAAAGCATTTTGTG
ATATGTGGAAGACGCTATGTGAAGTTTTACCTATCTTCTCAAAGACCTTTTCTTTTGTATTTTCTTTTGGTGTTTCTTAAAGCCAAACAA
AGAAATGTTCTTAAGGAGACAGGGTGGGTTTTTCTGTGGGCCTTTGTTGGTTTTTCTGTGGGCCATCGCCCTCTAATGGAATTGATCTCT
GGCTGTTTGATTTTTTTCATATTGTATTTTTAAAATTTGTTGTACAGTGCCCTGTGAGCACCAAGTACCACTAGATGAATAAAACGTATT

>36347_36347_4_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000539097_SF3B1_chr2_198283312_ENST00000335508_length(amino acids)=1606AA_BP=434
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNGGKTPDPKMN
ARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGR
AKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPT
PGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPP
AGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGT
PPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIIS
NLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVE
IIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQ
SPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMV
METIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRT
AVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAE
YVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRV
PELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQ

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>36347_36347_5_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000557538_SF3B1_chr2_198283312_ENST00000335508_length(transcript)=7569nt_BP=1550nt
ATTTGAAAACTTGGCAACCTTGGATTGGATGGATTCATATTTCTTAGTATAGAAGTTCTTGATATAACTGAAAAATTAAGTTAAACACTT
AATAAGTGGTGGTTACTCAGCACTTTTAGATGCTGTTTATAATAGATGACCTTTTCTAACTAATTTACAGTTTTTTGAAAGATAACTGAG
AGGTTGAGGGACGGAGATTTTCTTCAAGCAATTTTTTTTTTCATTTTAAATGAGCTCCCAATGTCGGAGTTTGGAAAACAAATTTGTCTT
TTTAAAAGAAGGTCTAGGAAACTCAAAACCTGAAGAATTGGAAGAAATCAGAATAGAAAATGGTAGGATAAGTTCTGAACGTCGAAAAGA
AAAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTTGCTCATCAGTTGCCACTTCCACATAATGT
GAGTTCGCATCTTGATAAGGCCTCTGTGATGAGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATAT
TGAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTTATGGTTCTCACAGATGATGGTGACATGAT
TTACATTTCTGATAATGTGAACAAATACATGGGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGA
CCATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAACAAAACACACAGCGAAGCTTTTTTCTCAG
AATGAAGTGTACCCTAACTAGCCGAGGAAGAACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGT
ATATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTGGTGCTGATTTGTGAACCCATTCCTCACCC
ATCAAATATTGAAATTCCTTTAGATAGCAAGACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTAC
CGAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCATGCTTTGGACTCTGATCATCTGACCAAAAC
TCATCATGATATGTTTACTAAAGGACAAGTCACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCA
AGCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTACGTTGTGAGTGGTATTATTCAGCACGACTT
GATTTTCTCCCTTCAACAAACAGAATGTGTCCTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATC
AGAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTGGCCCCAGCCGCTGGAGACACAATCATATC
TTTAGATTTTGGCAGCAACGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGGACTTACATGGATGTAATGCGAGAACAACACTTGAC
TAAAGAAGAACGAGAAATTAGGCAACAGCTAGCAGAAAAAGCTAAAGCTGGAGAACTAAAAGTCGTCAATGGAGCAGCAGCGTCCCAGCC
TCCATCAAAACGAAAACGGCGTTGGGATCAAACAGCTGATCAGACTCCTGGTGCCACTCCCAAAAAACTATCAAGTTGGGATCAGGCAGA
GACCCCTGGGCATACTCCTTCCTTAAGATGGGATGAGACACCAGGTCGTGCAAAGGGAAGCGAGACTCCTGGAGCAACCCCAGGCTCAAA
AATATGGGATCCTACACCTAGCCACACACCAGCGGGAGCTGCTACTCCTGGACGAGGTGATACACCAGGCCATGCGACACCAGGCCATGG
AGGCGCAACTTCCAGTGCTCGTAAAAACAGATGGGATGAAACCCCCAAAACAGAGAGAGATACTCCTGGGCATGGAAGTGGATGGGCTGA
GACTCCTCGAACAGATCGAGGTGGAGATTCTATTGGTGAAACACCGACTCCTGGAGCCAGTAAAAGAAAATCACGGTGGGATGAAACACC
AGCTAGTCAGATGGGTGGAAGCACTCCAGTTCTGACCCCTGGAAAGACACCAATTGGCACACCAGCCATGAACATGGCTACCCCTACTCC
AGGTCACATAATGAGTATGACTCCTGAACAGCTTCAGGCTTGGCGGTGGGAAAGAGAAATTGATGAGAGAAATCGCCCACTTTCTGATGA
GGAATTAGATGCTATGTTCCCAGAAGGATATAAGGTACTTCCTCCTCCAGCTGGTTATGTTCCTATTCGAACTCCAGCTCGAAAGCTGAC
AGCTACTCCAACACCTTTGGGTGGTATGACTGGTTTCCACATGCAAACTGAAGATCGAACTATGAAAAGTGTTAATGACCAGCCATCTGG
AAATCTTCCATTTTTAAAACCTGATGATATTCAATACTTTGATAAACTATTGGTTGATGTTGATGAATCAACACTTAGTCCAGAAGAGCA
AAAAGAGAGAAAAATAATGAAGTTGCTTTTAAAAATTAAGAATGGAACACCACCAATGAGAAAGGCTGCATTGCGTCAGATTACTGATAA
AGCTCGTGAATTTGGAGCTGGTCCTTTGTTTAATCAGATTCTTCCTCTGCTGATGTCTCCTACACTTGAGGATCAAGAGCGTCATTTACT
TGTGAAAGTTATTGATAGGATACTGTACAAACTTGATGACTTAGTTCGTCCATATGTGCATAAGATCCTCGTGGTCATTGAACCGCTATT
GATTGATGAAGATTACTATGCTAGAGTGGAAGGCCGAGAGATCATTTCTAATTTGGCAAAGGCTGCTGGTCTGGCTACTATGATCTCTAC
CATGAGACCTGATATAGATAACATGGATGAGTATGTCCGTAACACAACAGCTAGAGCTTTTGCTGTTGTAGCCTCTGCCCTGGGCATTCC
TTCTTTATTGCCCTTCTTAAAAGCTGTGTGCAAAAGCAAGAAGTCCTGGCAAGCGAGACACACTGGTATTAAGATTGTACAACAGATAGC
TATTCTTATGGGCTGTGCCATCTTGCCACATCTTAGAAGTTTAGTTGAAATCATTGAACATGGTCTTGTGGATGAGCAGCAGAAAGTTCG
GACCATCAGTGCTTTGGCCATTGCTGCCTTGGCTGAAGCAGCAACTCCTTATGGTATCGAATCTTTTGATTCTGTGTTAAAGCCTTTATG
GAAGGGTATCCGCCAACACAGAGGAAAGGGTTTGGCTGCTTTCTTGAAGGCTATTGGGTATCTTATTCCTCTTATGGATGCAGAATATGC
CAACTACTATACTAGAGAAGTGATGTTAATCCTTATTCGAGAATTCCAGTCTCCTGATGAGGAAATGAAAAAAATTGTGCTGAAGGTGGT
AAAACAGTGTTGTGGGACAGATGGTGTAGAAGCAAACTACATTAAAACAGAGATTCTTCCTCCCTTTTTTAAACACTTCTGGCAGCACAG
GATGGCTTTGGATAGAAGAAATTACCGACAGTTAGTTGATACTACTGTGGAGTTGGCAAACAAAGTAGGTGCAGCAGAAATTATATCCAG
GATTGTGGATGATCTGAAAGATGAAGCCGAACAGTACAGAAAAATGGTGATGGAGACAATTGAGAAAATTATGGGTAATTTGGGAGCAGC
AGATATTGATCATAAACTTGAAGAACAACTGATTGATGGTATTCTTTATGCTTTCCAAGAACAGACTACAGAGGACTCAGTAATGTTGAA
CGGCTTTGGCACAGTGGTTAATGCTCTTGGCAAACGAGTCAAACCATACTTGCCTCAGATCTGTGGTACAGTTTTGTGGCGTTTAAATAA
CAAATCTGCTAAAGTTAGGCAACAGGCAGCTGACTTGATTTCTCGAACTGCTGTTGTCATGAAGACTTGTCAAGAGGAAAAATTGATGGG
ACACTTGGGTGTTGTATTGTATGAGTATTTGGGTGAAGAGTACCCTGAAGTATTGGGCAGCATTCTTGGAGCACTGAAGGCCATTGTAAA
TGTCATAGGTATGCATAAGATGACTCCACCAATTAAAGATCTGCTGCCTAGACTCACCCCCATCTTAAAGAACAGACATGAAAAAGTACA
AGAGAATTGTATTGATCTTGTTGGTCGTATTGCTGACAGGGGAGCTGAATATGTATCTGCAAGAGAGTGGATGAGGATTTGCTTTGAGCT
TTTAGAGCTCTTAAAAGCCCACAAAAAGGCTATTCGTAGAGCCACAGTCAACACATTTGGTTATATTGCAAAGGCCATTGGCCCTCATGA
TGTATTGGCTACACTTCTGAACAACCTCAAAGTTCAAGAAAGGCAGAACAGAGTTTGTACCACTGTAGCAATAGCTATTGTTGCAGAAAC
ATGTTCACCCTTTACAGTACTCCCTGCCTTAATGAATGAATACAGAGTTCCTGAACTGAATGTTCAAAATGGAGTGTTAAAATCGCTTTC
CTTCTTGTTTGAATATATTGGTGAAATGGGAAAAGACTACATTTATGCCGTAACACCGTTACTTGAAGATGCTTTAATGGATAGAGACCT
TGTACACAGACAGACGGCTAGTGCAGTGGTACAGCACATGTCACTTGGGGTTTATGGATTTGGTTGTGAAGATTCGCTGAATCACTTGTT
GAACTATGTATGGCCCAATGTATTTGAGACATCTCCTCATGTAATTCAGGCAGTTATGGGAGCCCTAGAGGGCCTGAGAGTTGCTATTGG
ACCATGTAGAATGTTGCAATATTGTTTACAGGGTCTGTTTCACCCAGCCCGGAAAGTCAGAGATGTATATTGGAAAATTTACAACTCCAT
CTACATTGGTTCCCAGGACGCTCTCATAGCACATTACCCAAGAATCTACAACGATGATAAGAACACCTATATTCGTTATGAACTTGACTA
TATCTTATAATTTTATTGTTTATTTTGTGTTTAATGCACAGCTACTTCACACCTTAAACTTGCTTTGATTTGGTGATGTAAACTTTTAAA
CATTGCAGATCAGTGTAGAACTGGTCATAGAGGAAGAGCTAGAAATCCAGTAGCATGATTTTTAAATAACCTGTCTTTGTTTTTGATGTT
AAACAGTAAATGCCAGTAGTGACCAAGAACACAGTGATTATATACACTATACTGGAGGGATTTCATTTTTAATTCATCTTTATGAAGATT
TAGAACTCATTCCTTGTGTTTAAAGGGAATGTTTAATTGAGAAATAAACATTTGTGTACAAAATGCTAATTTGTGTGTGTTTTTTGAACA
TGACTTGTAAAATGCGGAACTTTGATAAAGTATTGGTTTATGTGGAATAAGTGGCTTAATTTCATTTTCTGTCACATGGTTTATAGAAAG
TAGTTAGCTGAATAAAAACTATATAAAGTGATGGCATCTTTGTCAAAATTCCATTGTTGTGTTAATAATGACAGCAAGAAGAGTAGCCTC
AGGGGATGTTCCCCTCAAACTAGCACAACCATTCCATCATCGTAGAAAAGTAGCACTTTTGCTAAACTGTCTTGAATATTTTGTACTTAC
ATAGCGCCTTTCATCTCTTGATTTCTCAAAATGCTTTATGAACACATTTAAAGAAAGTGGTTTAAGTCTTGTCCAACACTTGACAGGTCT
GCTGTGTTTAGCAAGTGAGGAATTTAACTTTACTTCAAAACTGCTTTCTGCCTATTAGGAGTGAGGATACCTAAGTAATGCTGATAGAAC
AGGACAATGTTGGGCTTTTCTCCATGTTATAAGCCACTACTCAGCAATGCATCAGTAAATACCTATTCACCCACTGTATGCCAGCCACTG
TGCTTATATGCAGGGGATGCAAAGGTGCATGAGACCTGCCCTCTACCTTTAAGAACAGTATAATGGAGAAGGGGAGACAAACCTTGTGAC
AGATTCCTTATGTACTGTGATAATACACAGTGGCAGCAGCTAAAATGTCTAGGTTTGCTTAGCTTTGTATTCAGTAATAATAAGTTGATC
TAAGAGTTCAGCATAAACTGAATGAAATGCCATTTAATGGTAGAGGAACCAAGCATTAAGGCAGTACTACACTTAATTTTTTAAGCAAAT
ATGTAAAGTATATTTTCAAACTTTTCTAATGTTATGGCCCCAAATTTCTTAGTTTTGGCCTTTTTACTACCTATACTATTTTTACTGTTT
TGTTTTGTCTCCATGTGGTAGTACTTCTGTGAACTCTAAAGGGAAAAAAAATTCTGCAAGCAGCATTAGTATATAACTACTACTGTAAGT
AAAACTGCCTATTGACACTTTAGGAGTTCCTGCTTCAGAAGCTTAGTTAAGAAACAGCTTGTGGCCGGGTGTGGTGGCTCATGCCTGTAA
TCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACGCGGTGAAGTCCCGTCTACTAA
AAATACAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATGGCTTGAACCCGGGAG
GCGGAGCTTGCAGTGAGCCGAGATAGCGCTGCTACACTCCAGCCTGGGCGACAGAGACTCCGTCTCAAAAAAAAAAAAAAAATTGACTTT
CAACAAATTGATAGTGAGCATTAAGGGTTTCCAAGTTGGATTTGTAACTCCTCATCATTCCTTGTATGACAACTTTCTGAATATATGTCA
CTATGTAGTAAAATTAAACACTCCAAACTCATCTTTCTGTTGTTAGAAGTTTTCAGCGGTACTTCCATGCAACTTTAAATCTCACTGCTC
TCTATGGTTGATGTCAAATGACCTTCAGTAATGACTGAGAATTGAATACAAATAGATTACAAAGCCAAAATTTGATGTTAAATGACTCAG
GAAATTTTAGTTGTATTTTCAATTCAAGTACTTAGTAGCCTACGTTTGCTTGGCCTCTGGTTCTTTATGGAAAATAGGCTTTGTAGTGGC
ATTGTGGAGCAAAGGAGACTGTTACACCTTAATTAACTTTTTTTACTGATGCAAATAATTTGAGGATAGAGAGGAGGGAAGTAGTGAAAG
CTATGACCTAAAACATTGGGACCAAATAGAGGCTCACAGATATTTGGATTATTTTATGTGCTTATTATTAAATAAGGAAAGCATTTTGTG
ATATGTGGAAGACGCTATGTGAAGTTTTACCTATCTTCTCAAAGACCTTTTCTTTTGTATTTTCTTTTGGTGTTTCTTAAAGCCAAACAA
AGAAATGTTCTTAAGGAGACAGGGTGGGTTTTTCTGTGGGCCTTTGTTGGTTTTTCTGTGGGCCATCGCCCTCTAATGGAATTGATCTCT
GGCTGTTTGATTTTTTTCATATTGTATTTTTAAAATTTGTTGTACAGTGCCCTGTGAGCACCAAGTACCACTAGATGAATAAAACGTATT

>36347_36347_5_HIF1A-SF3B1_HIF1A_chr14_62203827_ENST00000557538_SF3B1_chr2_198283312_ENST00000335508_length(amino acids)=1606AA_BP=434
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNGGKTPDPKMN
ARTYMDVMREQHLTKEEREIRQQLAEKAKAGELKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGR
AKGSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTERDTPGHGSGWAETPRTDRGGDSIGETPT
PGASKRKSRWDETPASQMGGSTPVLTPGKTPIGTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPP
AGYVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGT
PPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIIS
NLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLRSLVE
IIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQ
SPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMV
METIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRT
AVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAE
YVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRV
PELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQ

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Fusion Gene PPI Analysis for HIF1A-SF3B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneHIF1Achr14:62203827chr2:198283312ENST00000323441+9141_401416.3333333333333736.0TSGA10
HgeneHIF1Achr14:62203827chr2:198283312ENST00000337138+9151_401416.3333333333333827.0TSGA10
HgeneHIF1Achr14:62203827chr2:198283312ENST00000539097+9151_401440.3333333333333851.0TSGA10
TgeneSF3B1chr14:62203827chr2:198283312ENST000003355083251156_1157138.333333333333341305.0PHF5A
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325547_550138.333333333333341305.0PHF5A
TgeneSF3B1chr14:62203827chr2:198283312ENST00000409915471156_1157157.088.0PHF5A
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547547_550157.088.0PHF5A
TgeneSF3B1chr14:62203827chr2:198283312ENST00000414963051156_11570145.0PHF5A
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305547_5500145.0PHF5A
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325223_491138.333333333333341305.0PPP1R8
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547223_491157.088.0PPP1R8
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305223_4910145.0PPP1R8
TgeneSF3B1chr14:62203827chr2:198283312ENST00000335508325529_568138.333333333333341305.0SF3B14
TgeneSF3B1chr14:62203827chr2:198283312ENST0000040991547529_568157.088.0SF3B14
TgeneSF3B1chr14:62203827chr2:198283312ENST0000041496305529_5680145.0SF3B14
TgeneSF3B1chr14:62203827chr2:198283312ENST000003355083251248_1304138.333333333333341305.0SF3B3 and SF3B5
TgeneSF3B1chr14:62203827chr2:198283312ENST00000409915471248_1304157.088.0SF3B3 and SF3B5
TgeneSF3B1chr14:62203827chr2:198283312ENST00000414963051248_13040145.0SF3B3 and SF3B5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HIF1A-SF3B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HIF1A-SF3B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource