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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HIPK1-UROD (FusionGDB2 ID:36397)

Fusion Gene Summary for HIPK1-UROD

check button Fusion gene summary
Fusion gene informationFusion gene name: HIPK1-UROD
Fusion gene ID: 36397
HgeneTgene
Gene symbol

HIPK1

UROD

Gene ID

204851

7389

Gene namehomeodomain interacting protein kinase 1uroporphyrinogen decarboxylase
SynonymsMyak|Nbak2PCT|UPD
Cytomap

1p13.2

1p34.1

Type of geneprotein-codingprotein-coding
Descriptionhomeodomain-interacting protein kinase 1homeodomain interacting protein kinase 1-like proteinnuclear body associated kinase 2bnuclear body-associated kinase 2uroporphyrinogen decarboxylaseuroporphyrinogen III decarboxylase
Modification date2020031320200313
UniProtAcc

Q86Z02

.
Ensembl transtripts involved in fusion geneENST00000340480, ENST00000369553, 
ENST00000369554, ENST00000369555, 
ENST00000369558, ENST00000369561, 
ENST00000406344, ENST00000426820, 
ENST00000369559, 		ENST00000494399, 
ENST00000246337, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 1=25
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HIPK1 [Title/Abstract] AND UROD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHIPK1(114515938)-UROD(45480619), # samples:2
Anticipated loss of major functional domain due to fusion event.HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HIPK1-UROD seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
HIPK1-UROD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIPK1

GO:0006468

protein phosphorylation

24559171

HgeneHIPK1

GO:0010803

regulation of tumor necrosis factor-mediated signaling pathway

15701637

HgeneHIPK1

GO:0072577

endothelial cell apoptotic process

15701637

HgeneHIPK1

GO:0097191

extrinsic apoptotic signaling pathway

15701637


check buttonFusion gene breakpoints across HIPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UROD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE772547HIPK1chr1

114515938

-URODchr1

45480619

+
ChiTaRS5.0N/ABE772548HIPK1chr1

114515938

-URODchr1

45480619

+


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Fusion Gene ORF analysis for HIPK1-UROD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000340480ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000369553ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000369554ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000369555ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000369558ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000369561ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000406344ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
5CDS-3UTRENST00000426820ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+
Frame-shiftENST00000369553ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
Frame-shiftENST00000369554ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
Frame-shiftENST00000369555ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
Frame-shiftENST00000406344ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
Frame-shiftENST00000426820ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
In-frameENST00000340480ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
In-frameENST00000369558ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
In-frameENST00000369561ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
intron-3CDSENST00000369559ENST00000246337HIPK1chr1

114515938

-URODchr1

45480619

+
intron-3UTRENST00000369559ENST00000494399HIPK1chr1

114515938

-URODchr1

45480619

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369558HIPK1chr1114515938-ENST00000246337URODchr145480619+8162786420833871059
ENST00000369561HIPK1chr1114515938-ENST00000246337URODchr145480619+3782348416332401025
ENST00000340480HIPK1chr1114515938-ENST00000246337URODchr145480619+700267041942227677

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369558ENST00000246337HIPK1chr1114515938-URODchr145480619+0.000272080.9997279
ENST00000369561ENST00000246337HIPK1chr1114515938-URODchr145480619+0.0034131110.9965869
ENST00000340480ENST00000246337HIPK1chr1114515938-URODchr145480619+0.0004875120.99951243

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Fusion Genomic Features for HIPK1-UROD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIPK1-UROD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:114515938/chr1:45480619)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIPK1

Q86Z02

.
FUNCTION: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneURODchr1:114515938chr1:45480619ENST0000024633701037_410368.0RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIPK1chr1:114515938chr1:45480619ENST00000340480-115190_5180837.0DomainProtein kinase
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369553-114190_5180817.0DomainProtein kinase
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369558-116190_51801211.0DomainProtein kinase
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369559-115190_51801076.0DomainProtein kinase
HgeneHIPK1chr1:114515938chr1:45480619ENST00000406344-113190_5180817.0DomainProtein kinase
HgeneHIPK1chr1:114515938chr1:45480619ENST00000426820-116190_51801211.0DomainProtein kinase
HgeneHIPK1chr1:114515938chr1:45480619ENST00000340480-115844_8470837.0MotifNuclear localization signal 1 (NLS1)
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369553-114844_8470817.0MotifNuclear localization signal 1 (NLS1)
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369558-116844_84701211.0MotifNuclear localization signal 1 (NLS1)
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369559-115844_84701076.0MotifNuclear localization signal 1 (NLS1)
HgeneHIPK1chr1:114515938chr1:45480619ENST00000406344-113844_8470817.0MotifNuclear localization signal 1 (NLS1)
HgeneHIPK1chr1:114515938chr1:45480619ENST00000426820-116844_84701211.0MotifNuclear localization signal 1 (NLS1)
HgeneHIPK1chr1:114515938chr1:45480619ENST00000340480-115196_2040837.0Nucleotide bindingATP
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369553-114196_2040817.0Nucleotide bindingATP
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369558-116196_20401211.0Nucleotide bindingATP
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369559-115196_20401076.0Nucleotide bindingATP
HgeneHIPK1chr1:114515938chr1:45480619ENST00000406344-113196_2040817.0Nucleotide bindingATP
HgeneHIPK1chr1:114515938chr1:45480619ENST00000426820-116196_20401211.0Nucleotide bindingATP
HgeneHIPK1chr1:114515938chr1:45480619ENST00000340480-115891_9980837.0RegionRequired for localization to nuclear speckles
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369553-114891_9980817.0RegionRequired for localization to nuclear speckles
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369558-116891_99801211.0RegionRequired for localization to nuclear speckles
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369559-115891_99801076.0RegionRequired for localization to nuclear speckles
HgeneHIPK1chr1:114515938chr1:45480619ENST00000406344-113891_9980817.0RegionRequired for localization to nuclear speckles
HgeneHIPK1chr1:114515938chr1:45480619ENST00000426820-116891_99801211.0RegionRequired for localization to nuclear speckles


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Fusion Gene Sequence for HIPK1-UROD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36397_36397_1_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000340480_UROD_chr1_45480619_ENST00000246337_length(transcript)=7002nt_BP=6704nt
ATAGTAGGCAATATTTATGTGTCATTTATTATTATTGCTATTAGTGTTACCTATTATTTTCTTTTTGAACCCACTTATTGCCTAATTAGT
CATAGTTTGACAATTGCCCTTGTATTCCACCATGTCAAATATAAATTTACATAGATGAAGCTCCTGAAATTATTCTTGGGTTACCATTTT
GTGAAGCTATTGATATGTGGTCACTGGGCTGTGTGATAGCTGAGCTGTTCCTGGGATGGCCTCTTTATCCTGGTGCTTCAGAATATGATC
AGATTCGTTATATTTCACAAACACAAGGCTTGCCAGCTGAATATCTTCTCAGTGCCGGAACAAAAACAACCAGGTTTTTCAACAGAGATC
CTAATTTGGGGTACCCACTGTGGAGGCTTAAGACACCTGAAGAACATGAACTGGAGACTGGAATAAAATCAAAAGAAGCTCGGAAGTACA
TTTTTAATTGCTTAGATGACATGGCTCAGGTGAATATGTCTACAGACCTGGAGGGAACAGACATGTTGGCAGAGAAGGCAGACCGAAGAG
AATACATTGATCTGTTAAAGAAAATGCTCACAATTGATGCAGATAAGAGAATTACCCCTCTAAAAACTCTTAACCATCAGTTTGTGACAA
TGACTCACCTTTTGGATTTTCCACATAGCAATCATGTTAAGTCTTGTTTTCAGAACATGGAGATCTGCAAGCGGAGGGTTCACATGTATG
ATACAGTGAGTCAGATCAAGAGTCCCTTCACTACACATGTTGCCCCAAATACAAGCACAAATCTAACCATGAGCTTCAGCAATCAGCTCA
ATACAGTGCACAATCAGGCCAGTGTTCTAGCTTCCAGTTCTACTGCAGCAGCTGCTACTCTTTCTCTGGCTAATTCAGATGTCTCACTAC
TAAACTACCAGTCAGCTTTGTACCCATCATCTGCTGCACCAGTTCCTGGAGTTGCCCAGCAGGGTGTTTCCTTGCAGCCTGGAACCACCC
AGATTTGCACTCAGACAGATCCATTCCAACAGACATTTATAGTATGTCCACCTGCGTTTCAAACTGGACTACAAGCAACAACAAAGCATT
CTGGATTCCCTGTGAGGATGGATAATGCTGTACCGATTGTACCCCAGGCACCAGCTGCTCAGCCACTACAGATTCAGTCAGGAGTTCTCA
CGCAGGGAAGCTGTACACCACTAATGGTAGCAACTCTCCACCCTCAAGTAGCCACCATCACACCGCAGTATGCGGTGCCCTTTACTCTGA
GCTGCGCAGCCGGCCGGCCGGCGCTGGTTGAACAGACTGCCGCTGTACTGCAGGCGTGGCCTGGAGGGACTCAGCAAATTCTCCTGCCTT
CAACTTGGCAACAGTTGCCTGGGGTAGCTCTACACAACTCTGTCCAGCCCACAGCAATGATTCCAGAGGCCATGGGGAGTGGACAGCAGC
TAGCTGACTGGAGGAATGCCCACTCTCATGGCAACCAGTACAGCACTATCATGCAGCAGCCATCCTTGCTGACTAACCATGTGACATTGG
CCACTGCTCAGCCTCTGAATGTTGGTGTTGCCCATGTTGTCAGACAACAACAATCCAGTTCCCTCCCTTCGAAGAAGAATAAGCAGTCAG
CTCCAGTCTCTTCCAAGTCCTCTCTAGATGTTCTGCCTTCCCAAGTCTATTCTCTGGTTGGGAGCAGTCCCCTCCGCACCACATCTTCTT
ATAATTCCTTGGTCCCTGTCCAAGATCAGCATCAGCCCATCATCATTCCAGATACTCCCAGCCCTCCTGTGAGTGTCATCACTATCCGAA
GTGACACTGATGAGGAAGAGGACAACAAATACAAGCCCAGTAGCTCTGGACTGAAGCCAAGGTCTAATGTCATCAGTTATGTCACTGTCA
ATGATTCTCCAGACTCTGACTCTTCTTTGAGCAGCCCTTATTCCACTGATACCCTGAGTGCTCTCCGAGGCAATAGTGGATCCGTTTTGG
AGGGGCCTGGCAGAGTTGTGGCAGATGGCACTGGCACCCGCACTATCATTGTGCCTCCACTGAAAACTCAGCTTGGTGACTGCACTGTAG
CAACCCAGGCCTCAGGTCTCCTGAGCAATAAGACTAAGCCAGTCGCTTCAGTGAGTGGGCAGTCATCTGGATGCTGTATCACCCCCACAG
GGTATCGAGCTCAACGCGGGGGGACCAGTGCAGCACAACCACTCAATCTTAGCCAGCACTCACCCTAGCACTTTGGTGCACCAGGTCCCT
GTCAGTGTTGGGCCCAGCCTCCTCACTTCTGCCAGCGTGGCCCCTGCTCAGTACCAACACCAGTTTGCCACCCAATCCTACATTGGGTCT
TCCCGAGGCTCAACAATTTACACTGGATACCCGCTGAGTCCTACCAAGATCAGCCAGTATTCCTACTTATAGTTGGTGAGCATGAGGGAG
GAGGAATCATGGCTACCTTCTCCTGGCCCTGCGTTCTTAATATTGGGCTATGGAGAGATCCTCCTTTACCCTCTTGAAATTTCTTAGCCA
GCAACTTGTTCTGCAGGGGCCCACTGAAGCAGAAGGTTTTTCTCTGGGGGAACCTGTCTCAGTGTTGACTGCATTGTTGTAGTCTTCCCA
AAGTTTGCCCTATTTTTAAATTCATTATTTTTGTGACAGTAATTTTGGTACTTGGAAGAGTTCAGATGCCCATCTTCTGCAGTTACCAAG
GAAGAGAGATTGTTCTGAAGTTACCCTCTGAAAAATATTTTGTCTCTCTGACTTGATTTCTATAAATGCTTTTAAAAACAAGTGAAGCCC
CTCTTTATTTCATTTTGTGTTATTGTGATTGCTGGTCAGGAAAAATGCTGATAGAAGGAGTTGAAATCTGATGACAAAAAAAGAAAAATT
ACTTTTTGTTTGTTTATAAACTCAGACTTGCCTATTTTATTTTAAAAGCGGCTTACACAATCTCCCTTTTGTTTATTGGACATTTAAACT
TACAGAGTTTCAGTTTTGTTTTAATGTCATATTATACTTAATGGGCAATTGTTATTTTTGCAAAACTGGTTACGTATTACTCTGTGTTAC
TATTGAGATTCTCTCAATTGCTCCTGTGTTTGTTATAAAGTAGTGTTTAAAAGGCAGCTCACCATTTGCTGGTAACTTAATGTGAGAGAA
TCCATATCTGCGTGAAAACACCAAGTATTCTTTTTAAATGAAGCACCATGAATTCTTTTTTAAATTATTTTTTAAAAGTCTTTCTCTCTC
TGATTCAGCTTAAATTTTTTTATCGAAAAAGCCATTAAGGTGGTTATTATTACATGGTGGTGGTGGTTTTATTATATGCAAAATCTCTGT
CTATTATGAGATACTGGCATTGATGAGCTTTGCCTAAAGATTAGTATGAATTTTCAGTAATACACCTCTGTTTTGCTCATCTCTCCCTTC
TGTTTTATGTGATTTGTTTGGGGAGAAAGCTAAAAAAACCTGAAACCAGATAAGAACATTTCTTGTGTATAGCTTTTATACTTCAAAGTA
GCTTCCTTTGTATGCCAGCAGCAAATTGAATGCTCTCTTATTAAGACTTATATAATAAGTGCATGTAGGAATTGCAAAAAATATTTTAAA
AATTTATTACTGAATTTAAAAATATTTTAGAAGTTTTGTAATGGTGGTGTTTTAATATTTTACATAATTAAATATGTACATATTGATTAG
AAAAATATAACAAGCAATTTTTCCTGCTAACCCAAAATGTTATTTGTAATCAAATGTGTAGTGATTACACTTGAATTGTGTACTTAGTGT
GTATGTGATCCTCCAGTGTTATCCCGGAGATGGATTGATGTCTCCATTGTATTTAAACCAAAATGAACTGATACTTGTTGGAATGTATGT
GAACTAATTGCAATTATATTAGAGCATATTACTGTAGTGCTGAATGAGCAGGGGCATTGCCTGCAAGGAGAGGAGACCCTTGGAATTGTT
TTGCACAGGTGTGTCTGGTGAGGAGTTTTTCAGTGTGTGTCTCTTCCTTCCCTTTCTTCCTCCTTCCCTTATTGTAGTGCCTTATATGAT
AATGTAGTGGTTAATAGAGTTTACAGTGAGCTTGCCTTAGGATGGACCAGCAAGCCCCCGTGGACCCTAAGTTGTTCACCGGGATTTATC
AGAACAGGATTAGTAGCTGTATTGTGTAATGCATTGTTCTCAGTTTCCCTGCCAACATTGAAAAATAAAAACAGCAGCTTTTCTCCTTTA
CCACCACCTCTACCCCTTTCCATTTTGGATTCTCGGCTGAGTTCTCACAGAAGCATTTTCCCCATGTGGCTCTCTCACTGTGCGTTGCTA
CCTTGCTTCTGTGAGAATTCAGGAAGCAGGTGAGAGGAGTCAAGCCAATATTAAATATGCATTCTTTTAAAGTATGTGCAATCACTTTTA
GAATGAATTTTTTTTTCCTTTTCCCATGTGGCAGTCCTTCCTGCACATAGTTGACATTCCTAGTAAAATATTTGCTTGTTGAAAAAAACA
TGTTAACAGATGTGTTTATACCAAAGAGCCTGTTGTATTGCTTACCATGTCCCCATACTATGAGGAGAAGTTTTGTGGTGCCGCTGGTGA
CAAGGAACTCACAGAAAGGTTTCTTAGCTGGTGAAGAATATAGAGAAGGAACCAAAGCCTGTTGAGTCATTGAGGCTTTTGAGGTTTCTT
TTTTAACAGCTTGTATAGTCTTGGGGCCCTTCAAGCTGTGAAATTGTCCTTGTACTCTCAGCTCCTGCATGGATCTGGGTCAAGTAGAAG
GTACTGGGGATGGGGACATTCCTGCCCATAAAGGATTTGGGGAAAGAAGATTAATCCTAAAATACAGGTGTGTTCCATCTGAATTGAAAA
TGATATATTTGAGATATAATTTTAGGACTGGTTCTGTGTAGATAGAGATGGTGTCAAGGAGGTGCAGGATGGAGATGGGAGATTTCATGG
AGCCTGGTCAGCCAGCTCTGTACCAGGTTGAACACCGAGGAGCTGTCAAAGTATTTGGAGTTTCTTCATTGTAAGGAGTAAGGGCTTCCA
AGATGGGGCAGGTAGTCCGTACAGCCTACCAGGAACATGTTGTGTTTTCTTTATTTTTTAAAATCATTATATTGAGTTGTGTTTTCAGCA
CTATATTGGTCAAGATAGCCAAGCAGTTTGTATAATTTCTGTCACTAGTGTCATACAGTTTTCTGGTCAACATGTGTGATCTTTGTGTCT
CCTTTTTGCCAAGCACATTCTGATTTTCTTGTTGGAACACAGGTCTAGTTTCTAAAGGACAAATTTTTTGTTCCTTGTCTTTTTTCTGTA
AGGGACAAGATTTGTTGTTTTTGTAAGAAATGAGATGCAGGAAAGAAAACCAAATCCCATTCCTGCACCCCAGTCCAATAAGCAGATACC
ACTTAAGATAGGAGTCTAAACTCCACAGAAAAGGATAATACCAAGAGCTTGTATTGTTACCTTAGTCACTTGCCTAGCAGTGTGTGGCTT
TAAAAACTAGAGATTTTTCAGTCTTAGTCTGCAAACTGGCATTTCCGATTTTCCAGCATAAAAATCCACCTGTGTCTGCTGAATGTGTAT
GTATGTGCTCACTGTGGCTTTAGATTCTGTCCCTGGGGTTAGCCCTGTTGGCCCTGACAGGAAGGGAGGAAGCCTGGTGAATTTAGTGAG
CAGCTGGCCTGGGTCACAGTGACCTGACCTCAAACCAGCTTAAGGCTTTAAGTCCTCTCTCAGAACTTGGCATTTCCAACTTCTTCCTTT
CCGGGTGAGAGAAGAAGCGGAGAAGGGTTCAGTGTAGCCACTCTGGGCTCATAGGGACACTTGGTCACTCCAGAGTTTTTAATAGCTCCC
AGGAGGTGATATTATTTTCAGTGCTCAGCTGAAATACCAACCCCAGGAATAAGAACTCCATTTCAAACAGTTCTGGCCATTCTGAGCCTG
CTTTTGTGATTGCTCATCCATTGTCCTCCACTAGAGGGGCTAAGCTTGACTGCCCTTAGCCAGGCAAGCACAGTAATGTGTGTTTTGTTC
AGCATTATTATGCAAAAATTCACTAGTTGAGATGGTTTGTTTTAGGATAGGAAATGAAATTGCCTCTCAGTGACAGGAGTGGCCCGAGCC
TGCTTCCTATTTTGATTTTTTTTTTTTTTAACTGATAGATGGTGCAGCATGTCTACATGGTTGTTTGTTGCTAAACTTTATATAATGTGT
GGTTTCAATTCAGCTTGAAAAATAATCTCACTACATGTAGCAGTACATTATATGTACATTATATGTAATGTTAGTATTTCTGCTTTGAAT
CCTTGATATTGCAATGGAATTCCTACTTTATTAAATGTATTTGATATGCTAGTTATTGTGTGCGATTTAAACTTTTTTTGCTTTCTCCCT
TTTTTTGGTTGTGCGCTTTCTTTTACAACAAGCCTCTAGAAACAGATAGTTTCTGAGAATTACTGAGCTATGTTTGTAATGCAGATGTAC
TTAGGGAGTATGTAAAATAATCATTTTAACAAAAGAAATAGATATTTAAAATTTAATACTAACTATGGGAAAAGGGTCCATTGTGTAAAA
CATAGTTTATCTTTGGATTCAATGTTTGTCTTTGGTTTTACAAAGTAGCTTGTATTTTCAGTATTTTCTACATAATATGGTAAAATGTAG
AGCAATTGCAATGCATCAATAAAATGGGTAAATTTTCTGACTTATGGGGAAGACGGTGACATTGCAGGGCAACCTGGACCCCTGTGCCTT
GTATGCATCTGAGGAGGAGATCGGGCAGTTGGTGAAGCAGATGCTGGATGACTTTGGACCACATCGCTACATTGCCAACCTGGGCCATGG
GCTTTATCCTGACATGGACCCAGAACATGTGGGCGCCTTTGTGGATGCTGTGCATAAACACTCACGTCTGCTTCGACAGAACTGAGTGTA

>36397_36397_1_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000340480_UROD_chr1_45480619_ENST00000246337_length(amino acids)=677AA_BP=
MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCL
DDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQ
IKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQ
TDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAG
RPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQP
LNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE
EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQAS

--------------------------------------------------------------
>36397_36397_2_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000369558_UROD_chr1_45480619_ENST00000246337_length(transcript)=8162nt_BP=7864nt
GAGGCGGCGGCGGCGGCGGCGGGAAGGGGCTGGGTGGTGGAGCGGGAGGGAGGCTGAGGAGGCTCCCCCTGCGGGACGGGCGCGGGGACG
GCTCCGGGGGGCGGGGGCCGGGGCCCGGGCCGGCTCGCGCGGGGGGTATGATGACCCGGCTGCGGGGCCCCAGATCTCGTCTCCTCCGCC
GCCTCCTCACGGCAGCCCCAGCTCGCGGCTGAGAACCAGACACACCGGCGGTATGGCATCACAGCTGCAAGTGTTTTCGCCCCCATCAGT
GTCGTCGAGTGCCTTCTGCAGTGCGAAGAAACTGAAAATAGAGCCCTCTGGCTGGGATGTTTCAGGACAGAGTAGCAACGACAAATATTA
TACCCACAGCAAAACCCTCCCAGCCACACAAGGGCAAGCCAACTCCTCTCACCAGGTAGCAAATTTCAACATCCCTGCTTACGACCAGGG
CCTCCTCCTCCCAGCTCCTGCAGTGGAGCATATTGTTGTAACAGCCGCTGATAGCTCGGGCAGTGCTGCTACATCAACCTTCCAAAGCAG
CCAGACCCTGACTCACAGAAGCAACGTTTCTTTGCTTGAGCCATATCAAAAATGTGGATTGAAACGAAAAAGTGAGGAAGTTGACAGCAA
CGGTAGTGTGCAGATCATAGAAGAACATCCCCCTCTCATGCTGCAAAACAGGACTGTGGTGGGTGCTGCTGCCACAACCACCACTGTGAC
CACAAAGAGTAGCAGTTCCAGCGGAGAAGGGGATTACCAGCTGGTCCAGCATGAGATCCTTTGCTCTATGACCAATAGCTATGAAGTCTT
GGAGTTCCTAGGCCGGGGGACATTTGGACAGGTGGCTAAGTGCTGGAAGAGGAGCACCAAGGAAATTGTGGCTATTAAAATCTTGAAGAA
CCACCCCTCCTATGCCAGACAAGGACAGATTGAAGTGAGCATCCTTTCCCGCCTAAGCAGTGAAAATGCTGATGAGTATAATTTTGTCCG
TTCATACGAGTGCTTTCAGCATAAGAATCACACCTGCCTTGTTTTTGAAATGTTGGAGCAGAACTTATATGATTTTCTAAAGCAAAACAA
ATTTAGCCCACTGCCACTCAAGTACATCAGACCAATCTTGCAGCAGGTGGCCACAGCCTTGATGAAGCTCAAGAGTCTTGGTCTGATCCA
CGCTGACCTTAAGCCTGAAAACATCATGCTGGTTGATCCAGTTCGCCAGCCCTACCGAGTGAAGGTCATTGACTTTGGTTCTGCTAGTCA
CGTTTCCAAAGCTGTGTGCTCAACCTACTTACAGTCACGTTACTACAGAGCTCCTGAAATTATTCTTGGGTTACCATTTTGTGAAGCTAT
TGATATGTGGTCACTGGGCTGTGTGATAGCTGAGCTGTTCCTGGGATGGCCTCTTTATCCTGGTGCTTCAGAATATGATCAGATTCGTTA
TATTTCACAAACACAAGGCTTGCCAGCTGAATATCTTCTCAGTGCCGGAACAAAAACAACCAGGTTTTTCAACAGAGATCCTAATTTGGG
GTACCCACTGTGGAGGCTTAAGACACCTGAAGAACATGAACTGGAGACTGGAATAAAATCAAAAGAAGCTCGGAAGTACATTTTTAATTG
CTTAGATGACATGGCTCAGGTGAATATGTCTACAGACCTGGAGGGAACAGACATGTTGGCAGAGAAGGCAGACCGAAGAGAATACATTGA
TCTGTTAAAGAAAATGCTCACAATTGATGCAGATAAGAGAATTACCCCTCTAAAAACTCTTAACCATCAGTTTGTGACAATGACTCACCT
TTTGGATTTTCCACATAGCAATCATGTTAAGTCTTGTTTTCAGAACATGGAGATCTGCAAGCGGAGGGTTCACATGTATGATACAGTGAG
TCAGATCAAGAGTCCCTTCACTACACATGTTGCCCCAAATACAAGCACAAATCTAACCATGAGCTTCAGCAATCAGCTCAATACAGTGCA
CAATCAGGCCAGTGTTCTAGCTTCCAGTTCTACTGCAGCAGCTGCTACTCTTTCTCTGGCTAATTCAGATGTCTCACTACTAAACTACCA
GTCAGCTTTGTACCCATCATCTGCTGCACCAGTTCCTGGAGTTGCCCAGCAGGGTGTTTCCTTGCAGCCTGGAACCACCCAGATTTGCAC
TCAGACAGATCCATTCCAACAGACATTTATAGTATGTCCACCTGCGTTTCAAACTGGACTACAAGCAACAACAAAGCATTCTGGATTCCC
TGTGAGGATGGATAATGCTGTACCGATTGTACCCCAGGCACCAGCTGCTCAGCCACTACAGATTCAGTCAGGAGTTCTCACGCAGGGAAG
CTGTACACCACTAATGGTAGCAACTCTCCACCCTCAAGTAGCCACCATCACACCGCAGTATGCGGTGCCCTTTACTCTGAGCTGCGCAGC
CGGCCGGCCGGCGCTGGTTGAACAGACTGCCGCTGTACTGCAGGCGTGGCCTGGAGGGACTCAGCAAATTCTCCTGCCTTCAACTTGGCA
ACAGTTGCCTGGGGTAGCTCTACACAACTCTGTCCAGCCCACAGCAATGATTCCAGAGGCCATGGGGAGTGGACAGCAGCTAGCTGACTG
GAGGAATGCCCACTCTCATGGCAACCAGTACAGCACTATCATGCAGCAGCCATCCTTGCTGACTAACCATGTGACATTGGCCACTGCTCA
GCCTCTGAATGTTGGTGTTGCCCATGTTGTCAGACAACAACAATCCAGTTCCCTCCCTTCGAAGAAGAATAAGCAGTCAGCTCCAGTCTC
TTCCAAGTCCTCTCTAGATGTTCTGCCTTCCCAAGTCTATTCTCTGGTTGGGAGCAGTCCCCTCCGCACCACATCTTCTTATAATTCCTT
GGTCCCTGTCCAAGATCAGCATCAGCCCATCATCATTCCAGATACTCCCAGCCCTCCTGTGAGTGTCATCACTATCCGAAGTGACACTGA
TGAGGAAGAGGACAACAAATACAAGCCCAGTAGCTCTGGACTGAAGCCAAGGTCTAATGTCATCAGTTATGTCACTGTCAATGATTCTCC
AGACTCTGACTCTTCTTTGAGCAGCCCTTATTCCACTGATACCCTGAGTGCTCTCCGAGGCAATAGTGGATCCGTTTTGGAGGGGCCTGG
CAGAGTTGTGGCAGATGGCACTGGCACCCGCACTATCATTGTGCCTCCACTGAAAACTCAGCTTGGTGACTGCACTGTAGCAACCCAGGC
CTCAGGTCTCCTGAGCAATAAGACTAAGCCAGTCGCTTCAGTGAGTGGGCAGTCATCTGGATGCTGTATCACCCCCACAGGGTATCGAGC
TCAACGCGGGGGGACCAGTGCAGCACAACCACTCAATCTTAGCCAGCACTCACCCTAGCACTTTGGTGCACCAGGTCCCTGTCAGTGTTG
GGCCCAGCCTCCTCACTTCTGCCAGCGTGGCCCCTGCTCAGTACCAACACCAGTTTGCCACCCAATCCTACATTGGGTCTTCCCGAGGCT
CAACAATTTACACTGGATACCCGCTGAGTCCTACCAAGATCAGCCAGTATTCCTACTTATAGTTGGTGAGCATGAGGGAGGAGGAATCAT
GGCTACCTTCTCCTGGCCCTGCGTTCTTAATATTGGGCTATGGAGAGATCCTCCTTTACCCTCTTGAAATTTCTTAGCCAGCAACTTGTT
CTGCAGGGGCCCACTGAAGCAGAAGGTTTTTCTCTGGGGGAACCTGTCTCAGTGTTGACTGCATTGTTGTAGTCTTCCCAAAGTTTGCCC
TATTTTTAAATTCATTATTTTTGTGACAGTAATTTTGGTACTTGGAAGAGTTCAGATGCCCATCTTCTGCAGTTACCAAGGAAGAGAGAT
TGTTCTGAAGTTACCCTCTGAAAAATATTTTGTCTCTCTGACTTGATTTCTATAAATGCTTTTAAAAACAAGTGAAGCCCCTCTTTATTT
CATTTTGTGTTATTGTGATTGCTGGTCAGGAAAAATGCTGATAGAAGGAGTTGAAATCTGATGACAAAAAAAGAAAAATTACTTTTTGTT
TGTTTATAAACTCAGACTTGCCTATTTTATTTTAAAAGCGGCTTACACAATCTCCCTTTTGTTTATTGGACATTTAAACTTACAGAGTTT
CAGTTTTGTTTTAATGTCATATTATACTTAATGGGCAATTGTTATTTTTGCAAAACTGGTTACGTATTACTCTGTGTTACTATTGAGATT
CTCTCAATTGCTCCTGTGTTTGTTATAAAGTAGTGTTTAAAAGGCAGCTCACCATTTGCTGGTAACTTAATGTGAGAGAATCCATATCTG
CGTGAAAACACCAAGTATTCTTTTTAAATGAAGCACCATGAATTCTTTTTTAAATTATTTTTTAAAAGTCTTTCTCTCTCTGATTCAGCT
TAAATTTTTTTATCGAAAAAGCCATTAAGGTGGTTATTATTACATGGTGGTGGTGGTTTTATTATATGCAAAATCTCTGTCTATTATGAG
ATACTGGCATTGATGAGCTTTGCCTAAAGATTAGTATGAATTTTCAGTAATACACCTCTGTTTTGCTCATCTCTCCCTTCTGTTTTATGT
GATTTGTTTGGGGAGAAAGCTAAAAAAACCTGAAACCAGATAAGAACATTTCTTGTGTATAGCTTTTATACTTCAAAGTAGCTTCCTTTG
TATGCCAGCAGCAAATTGAATGCTCTCTTATTAAGACTTATATAATAAGTGCATGTAGGAATTGCAAAAAATATTTTAAAAATTTATTAC
TGAATTTAAAAATATTTTAGAAGTTTTGTAATGGTGGTGTTTTAATATTTTACATAATTAAATATGTACATATTGATTAGAAAAATATAA
CAAGCAATTTTTCCTGCTAACCCAAAATGTTATTTGTAATCAAATGTGTAGTGATTACACTTGAATTGTGTACTTAGTGTGTATGTGATC
CTCCAGTGTTATCCCGGAGATGGATTGATGTCTCCATTGTATTTAAACCAAAATGAACTGATACTTGTTGGAATGTATGTGAACTAATTG
CAATTATATTAGAGCATATTACTGTAGTGCTGAATGAGCAGGGGCATTGCCTGCAAGGAGAGGAGACCCTTGGAATTGTTTTGCACAGGT
GTGTCTGGTGAGGAGTTTTTCAGTGTGTGTCTCTTCCTTCCCTTTCTTCCTCCTTCCCTTATTGTAGTGCCTTATATGATAATGTAGTGG
TTAATAGAGTTTACAGTGAGCTTGCCTTAGGATGGACCAGCAAGCCCCCGTGGACCCTAAGTTGTTCACCGGGATTTATCAGAACAGGAT
TAGTAGCTGTATTGTGTAATGCATTGTTCTCAGTTTCCCTGCCAACATTGAAAAATAAAAACAGCAGCTTTTCTCCTTTACCACCACCTC
TACCCCTTTCCATTTTGGATTCTCGGCTGAGTTCTCACAGAAGCATTTTCCCCATGTGGCTCTCTCACTGTGCGTTGCTACCTTGCTTCT
GTGAGAATTCAGGAAGCAGGTGAGAGGAGTCAAGCCAATATTAAATATGCATTCTTTTAAAGTATGTGCAATCACTTTTAGAATGAATTT
TTTTTTCCTTTTCCCATGTGGCAGTCCTTCCTGCACATAGTTGACATTCCTAGTAAAATATTTGCTTGTTGAAAAAAACATGTTAACAGA
TGTGTTTATACCAAAGAGCCTGTTGTATTGCTTACCATGTCCCCATACTATGAGGAGAAGTTTTGTGGTGCCGCTGGTGACAAGGAACTC
ACAGAAAGGTTTCTTAGCTGGTGAAGAATATAGAGAAGGAACCAAAGCCTGTTGAGTCATTGAGGCTTTTGAGGTTTCTTTTTTAACAGC
TTGTATAGTCTTGGGGCCCTTCAAGCTGTGAAATTGTCCTTGTACTCTCAGCTCCTGCATGGATCTGGGTCAAGTAGAAGGTACTGGGGA
TGGGGACATTCCTGCCCATAAAGGATTTGGGGAAAGAAGATTAATCCTAAAATACAGGTGTGTTCCATCTGAATTGAAAATGATATATTT
GAGATATAATTTTAGGACTGGTTCTGTGTAGATAGAGATGGTGTCAAGGAGGTGCAGGATGGAGATGGGAGATTTCATGGAGCCTGGTCA
GCCAGCTCTGTACCAGGTTGAACACCGAGGAGCTGTCAAAGTATTTGGAGTTTCTTCATTGTAAGGAGTAAGGGCTTCCAAGATGGGGCA
GGTAGTCCGTACAGCCTACCAGGAACATGTTGTGTTTTCTTTATTTTTTAAAATCATTATATTGAGTTGTGTTTTCAGCACTATATTGGT
CAAGATAGCCAAGCAGTTTGTATAATTTCTGTCACTAGTGTCATACAGTTTTCTGGTCAACATGTGTGATCTTTGTGTCTCCTTTTTGCC
AAGCACATTCTGATTTTCTTGTTGGAACACAGGTCTAGTTTCTAAAGGACAAATTTTTTGTTCCTTGTCTTTTTTCTGTAAGGGACAAGA
TTTGTTGTTTTTGTAAGAAATGAGATGCAGGAAAGAAAACCAAATCCCATTCCTGCACCCCAGTCCAATAAGCAGATACCACTTAAGATA
GGAGTCTAAACTCCACAGAAAAGGATAATACCAAGAGCTTGTATTGTTACCTTAGTCACTTGCCTAGCAGTGTGTGGCTTTAAAAACTAG
AGATTTTTCAGTCTTAGTCTGCAAACTGGCATTTCCGATTTTCCAGCATAAAAATCCACCTGTGTCTGCTGAATGTGTATGTATGTGCTC
ACTGTGGCTTTAGATTCTGTCCCTGGGGTTAGCCCTGTTGGCCCTGACAGGAAGGGAGGAAGCCTGGTGAATTTAGTGAGCAGCTGGCCT
GGGTCACAGTGACCTGACCTCAAACCAGCTTAAGGCTTTAAGTCCTCTCTCAGAACTTGGCATTTCCAACTTCTTCCTTTCCGGGTGAGA
GAAGAAGCGGAGAAGGGTTCAGTGTAGCCACTCTGGGCTCATAGGGACACTTGGTCACTCCAGAGTTTTTAATAGCTCCCAGGAGGTGAT
ATTATTTTCAGTGCTCAGCTGAAATACCAACCCCAGGAATAAGAACTCCATTTCAAACAGTTCTGGCCATTCTGAGCCTGCTTTTGTGAT
TGCTCATCCATTGTCCTCCACTAGAGGGGCTAAGCTTGACTGCCCTTAGCCAGGCAAGCACAGTAATGTGTGTTTTGTTCAGCATTATTA
TGCAAAAATTCACTAGTTGAGATGGTTTGTTTTAGGATAGGAAATGAAATTGCCTCTCAGTGACAGGAGTGGCCCGAGCCTGCTTCCTAT
TTTGATTTTTTTTTTTTTTAACTGATAGATGGTGCAGCATGTCTACATGGTTGTTTGTTGCTAAACTTTATATAATGTGTGGTTTCAATT
CAGCTTGAAAAATAATCTCACTACATGTAGCAGTACATTATATGTACATTATATGTAATGTTAGTATTTCTGCTTTGAATCCTTGATATT
GCAATGGAATTCCTACTTTATTAAATGTATTTGATATGCTAGTTATTGTGTGCGATTTAAACTTTTTTTGCTTTCTCCCTTTTTTTGGTT
GTGCGCTTTCTTTTACAACAAGCCTCTAGAAACAGATAGTTTCTGAGAATTACTGAGCTATGTTTGTAATGCAGATGTACTTAGGGAGTA
TGTAAAATAATCATTTTAACAAAAGAAATAGATATTTAAAATTTAATACTAACTATGGGAAAAGGGTCCATTGTGTAAAACATAGTTTAT
CTTTGGATTCAATGTTTGTCTTTGGTTTTACAAAGTAGCTTGTATTTTCAGTATTTTCTACATAATATGGTAAAATGTAGAGCAATTGCA
ATGCATCAATAAAATGGGTAAATTTTCTGACTTATGGGGAAGACGGTGACATTGCAGGGCAACCTGGACCCCTGTGCCTTGTATGCATCT
GAGGAGGAGATCGGGCAGTTGGTGAAGCAGATGCTGGATGACTTTGGACCACATCGCTACATTGCCAACCTGGGCCATGGGCTTTATCCT
GACATGGACCCAGAACATGTGGGCGCCTTTGTGGATGCTGTGCATAAACACTCACGTCTGCTTCGACAGAACTGAGTGTATACCTTTACC

>36397_36397_2_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000369558_UROD_chr1_45480619_ENST00000246337_length(amino acids)=1059AA_BP=
MRTRHTGGMASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVE
HIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGE
GDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKN
HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTY
LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTP
EEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHV
KSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAA
PVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATL
HPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQ
YSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQP
IIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT

--------------------------------------------------------------
>36397_36397_3_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000369561_UROD_chr1_45480619_ENST00000246337_length(transcript)=3782nt_BP=3484nt
GAGGGAGGCTGAGGAGGCTCCCCCTGCGGGACGGGCGCGGGGACGGCTCCGGGGGGCGGGGGCCGGGGCCCGGGCCGGCTCGCGCGGGGG
GTATGATGACCCGGCTGCGGGGCCCCAGATCTCGTCTCCTCCGCCGCCTCCTCACGGCAGCCCCAGCTCGCGGCTGAGAACCAGACACAC
CGGCGGTATGGCATCACAGCTGCAAGTGTTTTCGCCCCCATCAGTGTCGTCGAGTGCCTTCTGCAGTGCGAAGAAACTGAAAATAGAGCC
CTCTGGCTGGGATGTTTCAGGACAGAGTAGCAACGACAAATATTATACCCACAGCAAAACCCTCCCAGCCACACAAGGGCAAGCCAACTC
CTCTCACCAGGTAGCAAATTTCAACATCCCTGCTTACGACCAGGGCCTCCTCCTCCCAGCTCCTGCAGTGGAGCATATTGTTGTAACAGC
CGCTGATAGCTCGGGCAGTGCTGCTACATCAACCTTCCAAAGCAGCCAGACCCTGACTCACAGAAGCAACGTTTCTTTGCTTGAGCCATA
TCAAAAATGTGGATTGAAACGAAAAAGTGAGGAAGTTGACAGCAACGGTAGTGTGCAGATCATAGAAGAACATCCCCCTCTCATGCTGCA
AAACAGGACTGTGGTGGGTGCTGCTGCCACAACCACCACTGTGACCACAAAGAGTAGCAGTTCCAGCGGAGAAGGGGATTACCAGCTGGT
CCAGCATGAGATCCTTTGCTCTATGACCAATAGCTATGAAGTCTTGGAGTTCCTAGGCCGGGGGACATTTGGACAGGTGGCTAAGTGCTG
GAAGAGGAGCACCAAGGAAATTGTGGCTATTAAAATCTTGAAGAACCACCCCTCCTATGCCAGACAAGGACAGATTGAAGTGAGCATCCT
TTCCCGCCTAAGCAGTGAAAATGCTGATGAGTATAATTTTGTCCGTTCATACGAGTGCTTTCAGCATAAGAATCACACCTGCCTTGTTTT
TGAAATGTTGGAGCAGAACTTATATGATTTTCTAAAGCAAAACAAATTTAGCCCACTGCCACTCAAGTACATCAGACCAATCTTGCAGCA
GGTGGCCACAGCCTTGATGAAGCTCAAGAGTCTTGGTCTGATCCACGCTGACCTTAAGCCTGAAAACATCATGCTGGTTGATCCAGTTCG
CCAGCCCTACCGAGTGAAGGTCATTGACTTTGGTTCTGCTAGTCACGTTTCCAAAGCTGTGTGCTCAACCTACTTACAGTCACGTTACTA
CAGAGCTCCTGAAATTATTCTTGGGTTACCATTTTGTGAAGCTATTGATATGTGGTCACTGGGCTGTGTGATAGCTGAGCTGTTCCTGGG
ATGGCCTCTTTATCCTGGTGCTTCAGAATATGATCAGATTCGTTATATTTCACAAACACAAGGCTTGCCAGCTGAATATCTTCTCAGTGC
CGGAACAAAAACAACCAGGTTTTTCAACAGAGATCCTAATTTGGGGTACCCACTGTGGAGGCTTAAGACACCTGAAGAACATGAACTGGA
GACTGGAATAAAATCAAAAGAAGCTCGGAAGTACATTTTTAATTGCTTAGATGACATGGCTCAGGTGAATATGTCTACAGACCTGGAGGG
AACAGACATGTTGGCAGAGAAGGCAGACCGAAGAGAATACATTGATCTGTTAAAGAAAATGCTCACAATTGATGCAGATAAGAGAATTAC
CCCTCTAAAAACTCTTAACCATCAGTTTGTGACAATGACTCACCTTTTGGATTTTCCACATAGCAATCATGTTAAGTCTTGTTTTCAGAA
CATGGAGATCTGCAAGCGGAGGGTTCACATGTATGATACAGCCAGTGTTCTAGCTTCCAGTTCTACTGCAGCAGCTGCTACTCTTTCTCT
GGCTAATTCAGATGTCTCACTACTAAACTACCAGTCAGCTTTGTACCCATCATCTGCTGCACCAGTTCCTGGAGTTGCCCAGCAGGGTGT
TTCCTTGCAGCCTGGAACCACCCAGATTTGCACTCAGACAGATCCATTCCAACAGACATTTATAGTATGTCCACCTGCGTTTCAAACTGG
ACTACAAGCAACAACAAAGCATTCTGGATTCCCTGTGAGGATGGATAATGCTGTACCGATTGTACCCCAGGCACCAGCTGCTCAGCCACT
ACAGATTCAGTCAGGAGTTCTCACGCAGGGAAGCTGTACACCACTAATGGTAGCAACTCTCCACCCTCAAGTAGCCACCATCACACCGCA
GTATGCGGTGCCCTTTACTCTGAGCTGCGCAGCCGGCCGGCCGGCGCTGGTTGAACAGACTGCCGCTGTACTGCAGGCGTGGCCTGGAGG
GACTCAGCAAATTCTCCTGCCTTCAACTTGGCAACAGTTGCCTGGGGTAGCTCTACACAACTCTGTCCAGCCCACAGCAATGATTCCAGA
GGCCATGGGGAGTGGACAGCAGCTAGCTGACTGGAGGAATGCCCACTCTCATGGCAACCAGTACAGCACTATCATGCAGCAGCCATCCTT
GCTGACTAACCATGTGACATTGGCCACTGCTCAGCCTCTGAATGTTGGTGTTGCCCATGTTGTCAGACAACAACAATCCAGTTCCCTCCC
TTCGAAGAAGAATAAGCAGTCAGCTCCAGTCTCTTCCAAGTCCTCTCTAGATGTTCTGCCTTCCCAAGTCTATTCTCTGGTTGGGAGCAG
TCCCCTCCGCACCACATCTTCTTATAATTCCTTGGTCCCTGTCCAAGATCAGCATCAGCCCATCATCATTCCAGATACTCCCAGCCCTCC
TGTGAGTGTCATCACTATCCGAAGTGACACTGATGAGGAAGAGGACAACAAATACAAGCCCAGTAGCTCTGGACTGAAGCCAAGGTCTAA
TGTCATCAGTTATGTCACTGTCAATGATTCTCCAGACTCTGACTCTTCTTTGAGCAGCCCTTATTCCACTGATACCCTGAGTGCTCTCCG
AGGCAATAGTGGATCCGTTTTGGAGGGGCCTGGCAGAGTTGTGGCAGATGGCACTGGCACCCGCACTATCATTGTGCCTCCACTGAAAAC
TCAGCTTGGTGACTGCACTGTAGCAACCCAGGCCTCAGGTCTCCTGAGCAATAAGACTAAGCCAGTCGCTTCAGTGAGTGGGCAGTCATC
TGGATGCTGTATCACCCCCACAGGGTATCGAGCTCAACGCGGGGGGACCAGTGCAGCACAACCACTCAATCTTAGCCAGCACTCACCCTA
GCACTTTGGTGCACCAGGTCCCTGTCAGTGTTGGGCCCAGCCTCCTCACTTCTGCCAGCGTGGCCCCTGCTCAGTACCAACACCAGTTTG
CCACCCAATCCTACATTGGGTCTTCCCGAGGCTCAACAATTTACACTGGATACCCGCTGAGTCCTACCAAGATCAGCCAGTATTCCTACT
TATAGTTGGTGAGCATGAGGGAGGAGGAATCATGGCTACCTTCTCCTGGCCCTGCGTTCTTAATTGGGGAAGACGGTGACATTGCAGGGC
AACCTGGACCCCTGTGCCTTGTATGCATCTGAGGAGGAGATCGGGCAGTTGGTGAAGCAGATGCTGGATGACTTTGGACCACATCGCTAC
ATTGCCAACCTGGGCCATGGGCTTTATCCTGACATGGACCCAGAACATGTGGGCGCCTTTGTGGATGCTGTGCATAAACACTCACGTCTG
CTTCGACAGAACTGAGTGTATACCTTTACCCTCAAGTACCACTAACACAGATGATTGATCGTTTCCAGGACAATAAAAGTTTCGGAGTTG

>36397_36397_3_HIPK1-UROD_HIPK1_chr1_114515938_ENST00000369561_UROD_chr1_45480619_ENST00000246337_length(amino acids)=1025AA_BP=
MRTRHTGGMASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVE
HIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGE
GDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKN
HTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTY
LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTP
EEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHV
KSCFQNMEICKRRVHMYDTASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCP
PAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVL
QAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQ
QSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSG
LKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVAS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HIPK1-UROD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIPK1chr1:114515938chr1:45480619ENST00000340480-115885_10930837.0TP53
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369553-114885_10930817.0TP53
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369558-116885_109301211.0TP53
HgeneHIPK1chr1:114515938chr1:45480619ENST00000369559-115885_109301076.0TP53
HgeneHIPK1chr1:114515938chr1:45480619ENST00000406344-113885_10930817.0TP53
HgeneHIPK1chr1:114515938chr1:45480619ENST00000426820-116885_109301211.0TP53


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HIPK1-UROD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HIPK1-UROD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource